KURAHASHI Hiroshi 倉橋洋史

Researcher Number	60508357
Other IDs
Affiliation (based on the past Project Information) *help	2012: 東北大学, 大学院・医学系研究科, 助教 2011 – 2012: 東北大学, 医学(系)研究科(研究院), 助教 2009 – 2010: The University of Tokyo, 医科学研究所, 助教
Review Section/Research Field	Principal Investigator Cell biology / Molecular biology
Keywords	Principal Investigator 脳神経疾患 / 感染症 / 酵母 / 蛋白質 / アミロイド / プリオン / GET pathway / 膜タンパク質 / 凝集 / タンパク質

Research Projects
(2 results)
Research Products
(35 results)

Cellular systems regulating prion propagationPrincipal Investigator
- Principal Investigator
  
  KURAHASHI Hiroshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Tohoku University
Cellular systems of prion maintenancePrincipal Investigator
- Principal Investigator
  
  KURAHASHI Hiroshi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo

All 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Clearance of yeast prions by misfolded multi-transmembrane proteins2013
- Author(s)
  Chie Arai, Hiroshi Kurahashi, Masao Ishiwata, Keita Oishi, Yoshikazu Nakamura
- Journal Title
  
  Biochimie
  
  Volume: 95 Issue: 6 Pages: 1223-1232
- DOI
  10.1016/j.biochi.2013.01.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770219, KAKENHI-PROJECT-24241074
[Journal Article] A bipolar functionality of Q/N-rich proteins: Lsm4 amyloid causes clearance of yeast prions2013
- Author(s)
  Keita Oishi, Hiroshi Kurahashi, Chan-Gi Pack, Yasushi Sako, Yoshikazu Nakamura
- Journal Title
  
  Microbiology Open
  
  Volume: (印刷中) Issue: 3 Pages: 415-430
- DOI
  10.1002/mbo3.83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770219, KAKENHI-PROJECT-24241074
[Journal Article] A bipolar personality of yeast prion proteins2011
- Author(s)
  Hiroshi Kurahashi, Keita Oishi, Yoshikazu Nakamura
- Journal Title
  
  Prion
  
  Volume: 5 Issue: 4 Pages: 305-310
- DOI
  10.4161/pri.18307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770219
[Journal Article] [PSI+] aggregate enlargement in rnq1 non-prion domain mutants, leading to a loss-of-prion in yeast2011
- Author(s)
  Hiroshi Kurahashi, Chan-Gi Pack, Shoichiro Shibata, Keita Oishi, Yasushi Sako, Yoshikazu Nakamura
- Journal Title
  
  Genes Cells
  
  Volume: 16 Issue: 5 Pages: 576-589
- DOI
  10.1111/j.1365-2443.2011.01511.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770219
[Journal Article] [PSI+] aggregate enlargement in rnq1 non-prion domain mutants, leading to a loss-of-prion in yeast.2011
- Author(s)
  Hiroshi Kurahashi, Chan-Gi Pack, Shoichiro Shibata, Keita Oishi, Yasushi Sako, Yoshikazu Nakamura
- Journal Title
  
  Genes Cells 16
  
  Pages: 576-589
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870009
[Journal Article] [PSI%+] aggregate enlargement in rnql nonprion domain mutants, leading to a loss of prion in yeast2011
- Author(s)
  Hiroshi Kurahashi, Chan-Gi Pack, Shoichiro Shibata, Keita Oishi, Yasushi Sako, Yoshikazu Nakamura
- Journal Title
  
  Genes to Cells
  
  Volume: (in press)(掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870009
[Journal Article] Localization of prion-destabilizing mutations in the N-terminal non-prion domain of Rnq1 in Saccharomyces cerevisiae2009
- Author(s)
  Shoichiro Shibata, Hiroshi Kurahashi, Yoshikazu Nakamura
- Journal Title
  
  Prion VOL.3
  
  Pages: 250-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870009
[Journal Article] Localization of prion-destabilizing mutations in the N-terminal non-prion domain of Rnq1 in Saccharomyces cerevisiae.2009
- Author(s)
  Shoichiro Shibata, Hiroshi Kurahashi, Yoshikazu Nakamura
- Journal Title
  
  Prion 3
  
  Pages: 250-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870009
[Presentation] Q/N-rich蛋白質の二重人格性:Lsm4による酵母プリオン消失現象の機序解析2012
- Author(s)
  大石圭太,倉橋洋史,白燦基,佐甲靖志,中村義一
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-23770219
[Presentation] A yeast membrane perturbation selected as loss-of-prion mutants induces heat shock response and ER stress2012
- Author(s)
  Chie Arai, Masao Ishiwata, Keita Oishi, Hiroshi Kurahashi, Koichi Ito, Yoshikazu Nakamura
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Year and Date
  2012-06-20
- Data Source
  KAKENHI-PROJECT-23770219
[Presentation] Lsm4 is a general prion inhibitor in yeast Saccharomyces cerevisiae2012
- Author(s)
  Keita Oishi, Hiroshi Kurahashi, Chan-Gi Pack, Yasushi Sako, Yoshikazu Nakamura
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Year and Date
  2012-06-22
- Data Source
  KAKENHI-PROJECT-23770219
[Presentation] Applicational research from yeast prion to mammalian prion with Gpg1 and Rnq1-100 that inhibit propagation of yeast prion2012
- Author(s)
  Hiroshi Kurahashi, Katsumi Doh-ura
- Organizer
  Asian Pacific Prion Symposium (APPS) 2012
- Place of Presentation
  横浜
- Year and Date
  2012-07-29
- Data Source
  KAKENHI-PROJECT-23770219
[Presentation] Anti-prion genes in yeast2012
- Author(s)
  Hiroshi Kurahashi
- Organizer
  FURANO CONFERENCE "Advanced Bioregulation and RNA"(招待講演)
- Place of Presentation
  富良野
- Data Source
  KAKENHI-PROJECT-23770219
[Presentation] Anti-prion genes in yeast. FURANO CONFERENCE2012
- Author(s)
  Hiroshi Kurahashi
- Organizer
  Advanced Bioregulation and RNA
- Place of Presentation
  富良野
- Year and Date
  2012-03-06
- Data Source
  KAKENHI-PROJECT-23770219
[Presentation] A novel epigenetic regulation of yeast translation termination factor (eRF3) prion2011
- Author(s)
  Chie Arai, Hiroshi Kurahashi, Yoshikazu Nakamura
- Organizer
  RNA 2011 Kyoto
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23770219
[Presentation] [PSI+] aggregate enlargement in rnq1 nonprion domain mutants, leading to a loss of prion in yeast2011
- Author(s)
  Hiroshi Kurahashi, Chan-Gi Pack, Shoichiro Shibata, Keita Oishi, Yasushi Sako, Yoshikazu Nakamura
- Organizer
  Asian Pacific Prion Symposium (APPS) 2011
- Place of Presentation
  軽井沢
- Year and Date
  2011-07-10
- Data Source
  KAKENHI-PROJECT-23770219
[Presentation] A novel epigenetic regulation of yeast translation termination factor (eRF3) prion2011
- Author(s)
  Chie Arai, Hiroshi Kurahashi, Yoshikazu Nakamura
- Organizer
  RNA 2011Kyoto
- Place of Presentation
  京都
- Year and Date
  2011-06-17
- Data Source
  KAKENHI-PROJECT-23770219
[Presentation] 酵母におけるrnq1の非プリオンドメインの変異は[PSI+]プリオン凝集体を増大してプリオン消失を引き起こす2011
- Author(s)
  Hiroshi Kurahashi, Chan-Gi Pack, Shoichiro Shibata, Keita Oishi, Yasushi Sako, Yoshikazu Nakamura
- Organizer
  第３４回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23770219
[Presentation] [PSI+] aggregate enlargement in rnq1 nonprion domain mutants, leading to a loss of prion in yeast.2011
- Author(s)
  Hiroshi Kurahashi, Chan-Gi Pack, Shoichiro Shibata, Keita Oishi, Yasushi Sako, Yoshikazu Nakamura
- Organizer
  Asian Pacific Prion Symposium (APPS) 2011
- Place of Presentation
  軽井沢
- Data Source
  KAKENHI-PROJECT-23770219
[Presentation] 酵母における rnq1 の非プリオンドメインの変異は[PSI+]プリオン凝集体を増大してプリオン消失を引き起こす2011
- Author(s)
  Hiroshi Kurahashi, Chan-Gi Pack, Shoichiro Shibata, Keita Oishi, Yasushi Sako, Yoshikazu Nakamura
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-23770219
[Presentation] Lsm4p is a novel anti-prion agent in yeast Saccharomyces cerevisiae2011
- Author(s)
  Keita Oishi, Hiroshi Kurahashi, Yoshikazu Nakamura
- Organizer
  RNA 2011 Kyoto
- Place of Presentation
  京都
- Year and Date
  2011-06-17
- Data Source
  KAKENHI-PROJECT-23770219
[Presentation] LOCALIZATION OF AMYLOID-DESTABILIZING MUTATIONS IN THE N-TERMINAL DOMAIN OF RNQ1 IN SACCHAROMYCES CEREVISIAE.2010
- Author(s)
  Hiroshi Kurahashi, Shoichiro Shibata, Yoshikazu Nakamura
- Organizer
  The 4th International Symposium of Molecular Science of Fluctuations toward Biological Functions
- Place of Presentation
  大津
- Year and Date
  2010-12-01
- Data Source
  KAKENHI-PROJECT-21870009
[Presentation] Alterations in predicted α-helices of non-prion domains of Rnq1 affect homologous and heterologous prion propagations in yeast.2010
- Author(s)
  Hiroshi Kurahashi, Shoichiro Shibata, Yoshikazu Nakamura
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  奈良
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-21870009
[Presentation] LOCALIZATION OF AMYLOID-DESTABILIZING MUTATIONS IN THE N-TERMINAL DOMAIN OF RNQ1 IN SACCHAROMYCES CEREVISIAE2010
- Author(s)
  Hiroshi Kurahashi, Shoichiro Shibata, Yoshikazu Nakamura
- Organizer
  The 4th International Symposium of Molecular Science of Fluctuations toward Biological Functions
- Place of Presentation
  大津ピアザ淡海
- Year and Date
  2010-12-01
- Data Source
  KAKENHI-PROJECT-21870009
[Presentation] 出芽酵母のプリオン動態におけるQ/N-rich領域の"二重人格性"2010
- Author(s)
  大石圭太,倉橋洋史,中村義一
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21870009
[Presentation] Rnq1の非プリオンドメインの変異は、同種と異種のプリオン維持阻害を引き起こす2010
- Author(s)
  倉橋洋史,柴田勝一郎,中村義一
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21870009
[Presentation] Rnq1の非プリオンドメインの変異は、同種と異種のプリオン維持阻害を引き起こす2010
- Author(s)
  倉橋洋史, 柴田勝一郎, 中村義一
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌,札幌コンベンションセンター
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21870009
[Presentation] The mechanism of yeast prion elimination.2010
- Author(s)
  Chie Arai, Hiroshi Kurahashi, Keita Oishi, Yoshikazu Nakamura
- Organizer
  A FEBS Advanced Lecture Course : Analysis and Engineering of Biomolecular Systems
- Place of Presentation
  Island of Spetes, Greece
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-21870009
[Presentation] A novel prion antagonist in yeast.2010
- Author(s)
  Keita Oishi, Hiroshi Kurahashi, Yoshikazu Nakamura
- Organizer
  A FEBS Advanced Lecture Course : Analysis and Engineering of Biomolecular Systems
- Place of Presentation
  Island of Spetes, Greece
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-21870009
[Presentation] Alterations in predicted α-helices of non-prion domains of Rnql affect homologous and heterologous prion propagations in yeast2010
- Author(s)
  Hiroshi Kurahashi, Shoichiro Shibata, Yoshikazu Nakamura
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  奈良ホテル日航奈良
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-21870009
[Presentation] Localization of prion-destabilizing mutations in the N-terminal non-prion domain of Rnq1 in Saccharomyces cerevisiae.2009
- Author(s)
  Shoichiro Shibata, Hiroshi Kurahashi, Yoshikazu Nakamura
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21870009
[Presentation] Applicational research from yeast prion to mammalian prion with Gpg1 and Rnq1∆100 that inhibit propagation of yeast prion
- Author(s)
  Hiroshi Kurahashi, Katsumi Doh-ura
- Organizer
  Asian Pacific Prion Symposium (APPS) 2012
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23770219
[Presentation] Lsm4 is a general prion inhibitor in yeast Saccharomyces cerevisiae
- Author(s)
  Keita Oishi, Hiroshi Kurahashi, Chan-Gi Pack, Yasushi Sako, Yoshikazu Nakamura
- Organizer
  第１２回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23770219
[Presentation] Q/N-rich蛋白質の二重人格性：Lsm4による酵母プリオン消失現象の機序解析
- Author(s)
  大石圭太, 倉橋洋史, 白燦基, 佐甲靖志, 中村義一
- Organizer
  第３５回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23770219
[Presentation] A yeast membrane perturbation selected as loss-of-prion mutants induces heat shock response and ER stress
- Author(s)
  Chie Arai, Masao Ishiwata, Keita Oishi, Hiroshi Kurahashi, Koichi Ito, Yoshikazu Nakamura
- Organizer
  第１２回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23770219

KURAHASHI Hiroshi 倉橋 洋史

Research Projects

Research Products

Cellular systems regulating prion propagationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cellular systems of prion maintenancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Clearance of yeast prions by misfolded multi-transmembrane proteins2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A bipolar functionality of Q/N-rich proteins: Lsm4 amyloid causes clearance of yeast prions2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A bipolar personality of yeast prion proteins2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] [PSI+] aggregate enlargement in rnq1 non-prion domain mutants, leading to a loss-of-prion in yeast2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] [PSI+] aggregate enlargement in rnq1 non-prion domain mutants, leading to a loss-of-prion in yeast.2011

Author(s)

Journal Title

Data Source

[Journal Article] [PSI%+] aggregate enlargement in rnql nonprion domain mutants, leading to a loss of prion in yeast2011

Author(s)

Journal Title

Data Source

[Journal Article] Localization of prion-destabilizing mutations in the N-terminal non-prion domain of Rnq1 in Saccharomyces cerevisiae2009

Author(s)

Journal Title

Data Source

[Journal Article] Localization of prion-destabilizing mutations in the N-terminal non-prion domain of Rnq1 in Saccharomyces cerevisiae.2009

Author(s)

Journal Title

Data Source

[Presentation] Q/N-rich蛋白質の二重人格性:Lsm4による酵母プリオン消失現象の機序解析2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] A yeast membrane perturbation selected as loss-of-prion mutants induces heat shock response and ER stress2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Lsm4 is a general prion inhibitor in yeast Saccharomyces cerevisiae2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Applicational research from yeast prion to mammalian prion with Gpg1 and Rnq1-100 that inhibit propagation of yeast prion2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Anti-prion genes in yeast2012

Author(s)

Organizer

Place of Presentation

Data Source

KURAHASHI Hiroshi 倉橋洋史