Mizoguchi Fumitaka 溝口史高

… Alternative Names

MIZOGUCHI Fumitaka 溝口史高

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Researcher Number	60510360
Other IDs	https://orcid.org/0000-0002-3956-7122
Affiliation (based on the past Project Information) *help	2018 – 2019: 東京医科歯科大学, 大学院医歯学総合研究科, 助教 2017: 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 2016: 東京医科歯科大学, 大学院医歯学総合研究科, 助教 2014: 東京医科歯科大学, 大学院医歯学総合研究科, 助教 2012 – 2014: 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 2009 – 2011: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 2009: 東京医科歯科大学, 医歯学総合研究科, 助教
Review Section/Research Field	Principal Investigator 膠原病・アレルギー・感染症内科学 / Basic Section 54020:Connective tissue disease and allergy-related / Collagenous pathology/Allergology Except Principal Investigator 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator 滑膜線維芽細胞 / 関節リウマチ / トランスクリプトミクス / 線維芽細胞 / single cell RNA-seq / 多発性筋炎/皮膚筋炎 / 特発性炎症性筋疾患 / 免疫学 / 病理学 / 滑膜組織 … More / 幹細胞 / 血球系幹細胞 / 間葉系幹細胞 / 滑膜繊維芽細胞 / microRNA … More Except Principal Investigator 関節リウマチ / MMP-3 / Il-6 / microRNA阻害剤ライブラリー / micro RNA / microRNA / マクロファージ / サイクリン依存性キナーゼ阻害因子 / 細胞周期制御 / CDK4/6 / 治療法 / TREM-1 / CDK4/6阻害薬 / TREM-1リガンド / 病理学 / 免疫学 / 薬学 / 臨床 / 内科 / リウマチ学 Less

多発性筋炎/皮膚筋炎の筋組織の免疫表現型解析による病態解明と疾患再分類への挑戦Principal Investigator
- Principal Investigator
  
  溝口史高
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Tokyo Medical and Dental University
Development of new therapeutic strategies targeting rheumatoid arthritis-associated fibroblast subsetPrincipal Investigator
- Principal Investigator
  
  Mizoguchi Fumitaka
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Tokyo Medical and Dental University
microRNA as a target to develop a novel treatment for rheumatoid arthritis and to clarify a new pathology in rheumatoid arthritis
- Principal Investigator
  
  MIYASAKA Nobuyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Tokyo Medical and Dental University
Identification of the origin of pathogenic synovial fibroblasts in rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  MIZOGUCHI Fumitaka
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Tokyo Medical and Dental University
Development of new anti-rheumatic drugs
- Principal Investigator
  
  KOHSAKA Hitoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Tokyo Medical and Dental University
Identification of miRNA as therapeutic target in rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  MIZOGUCHI Fumitaka
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Tokyo Medical and Dental University

All 2018 2017 2016 2013 2010 2009 Other

All Journal Article Presentation Book

[Book] 骨に関わる主な疾病発症のメカニズム第2章関節リウマチ. 骨研究最前線2013
- Author(s)
  溝口史高
- Data Source
  KAKENHI-PROJECT-24790994
[Journal Article] Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue2018
- Author(s)
  Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A; Accelerating Medicines Partnership RA/SLE Network, et al.
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 20 Issue: 1 Pages: 139-139
- DOI
  10.1186/s13075-018-1631-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09889
[Journal Article] Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis2018
- Author(s)
  Mizoguchi F, Slowikowski K, Wei K, Marshall JL, Rao DA, Chang SK, Nguyen HN, Noss EH, Turner JD, Earp BE, Blazar PE, Wright J, Simmons BP, Donlin LT, Kalliolias GD, Goodman SM, Bykerk VP, Ivashkiv LB, Lederer JA, Hacohen N, Nigrovic PA, Filer A, Buckley CD, Raychaudhuri S, Brenner MB
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 789-789
- DOI
  10.1038/s41467-018-02892-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09889
[Journal Article] RA 骨破壊のメカニズム2013
- Author(s)
  溝口史高
- Journal Title
  
  Journal of Rheumatology Clinical Research
  
  Volume: 2(2) Pages: 89-93
- Data Source
  KAKENHI-PROJECT-24790994
[Journal Article] Hypoxia-induced Abrogation of Contact-dependent Inhibition of Rheumatoid Arthritis Synovial Fibroblast Proliferation2009
- Author(s)
  Nonomura Y, Mizoguchi F, 他3名, Miyasaka N, Kohsaka H
- Journal Title
  
  J Rheumatol 36
  
  Pages: 698-705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249060
[Presentation] シングルセル解析による線維芽細胞亜群の同定と関節リウマチの病態解析2018
- Author(s)
  溝口史高
- Organizer
  第46回日本臨床免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09889
[Presentation] シングルセル解析による線維芽細胞サブセットの同定と関節リウマチの病態解析2017
- Author(s)
  溝口史高
- Organizer
  第35回日本骨代謝学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09889
[Presentation] 関節リウマチ滑膜病理の脱構築による病態解析2017
- Author(s)
  溝口史高
- Organizer
  第４回JCRベーシックリサーチカンファレンス
- Invited
- Data Source
  KAKENHI-PROJECT-16K09889
[Presentation] IL6を高産生する線維芽細胞サブセットを制御する転写因子の同定2017
- Author(s)
  溝口史高、小宮陽仁、上阪等
- Organizer
  第45回臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K09889
[Presentation] 関節リウマチの病態を担う新規線維芽細胞サブセットの同定2017
- Author(s)
  溝口史高
- Organizer
  日本臨床免疫学会Midwinter Seminar XI
- Place of Presentation
  ANAインターコンチネンタル万座ビーチホテル（恩納村、沖縄）
- Year and Date
  2017-02-22
- Data Source
  KAKENHI-PROJECT-16K09889
[Presentation] 単一細胞解析による関節リウマチの病態を担う線維芽細胞サブセットの同定2017
- Author(s)
  溝口史高
- Organizer
  第61回日本リウマチ学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09889
[Presentation] Single cell transcriptomics and protein expression analysis define disease-specific fibroblast subsets in rheumatoid arthritis joint tissue2016
- Author(s)
  Fumitaka Mizoguchi, Kamil Slowikowski, Soumya Raychaudhuri, Michael B Brenner
- Organizer
  第２回日本骨免疫学会
- Place of Presentation
  ホテルモントレ沖縄スパ＆リゾート（恩納村、沖縄）
- Year and Date
  2016-07-06
- Data Source
  KAKENHI-PROJECT-16K09889
[Presentation] シングルセル解析による関節リウマチの病態を担う線維芽細胞サブセットの同定2016
- Author(s)
  溝口史高
- Organizer
  Rising Star Symposium, 第44回臨床免疫学会総会
- Place of Presentation
  京王プラザホテル（新宿、東京）
- Year and Date
  2016-09-08
- Invited
- Data Source
  KAKENHI-PROJECT-16K09889
[Presentation] 関節リウマチの病態を担う新規線維芽細胞サブセットの同定2016
- Author(s)
  溝口史高
- Organizer
  第15回リウマチ膠原病・よつやセミナー
- Place of Presentation
  ベルサール西新宿（新宿、東京）
- Year and Date
  2016-09-24
- Invited
- Data Source
  KAKENHI-PROJECT-16K09889
[Presentation] p16INK4a exerts anti-inflammatory effects through acceleration of IRAK1 degradation in macrophages2010
- Author(s)
  Hitoshi Kohsaka, Yousuke Murakami, Fumitaka Mizoguchi, Nobuyuki Miyasaka
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Osaka
- Data Source
  KAKENHI-PROJECT-21249060
[Presentation] miR-31 contributes to the optimal bone resorption by osteoclasts2010
- Author(s)
  Fumitaka Mizoguchi, Yousuke Murakami, Nobuyuki Miyasaka, Hitoshi Kohsaka
- Organizer
  3^<rd> International Conference on Osteoimmunology
- Place of Presentation
  Santorini
- Data Source
  KAKENHI-PROJECT-21249060
[Presentation] 転写抑制因子ets variant 6の発現を抑制するmicroRNAの阻害は、関節リウマチ滑膜線維芽細胞からの matrix metalloproteinase-3とinterleukin-6産生を抑制する
- Author(s)
  長谷川久紀、溝口史高、宮坂信之、上阪等
- Organizer
  第42回日本臨床免疫学会総会
- Place of Presentation
  京王プラザホテル(東京都新宿)
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24591443

1. MIYASAKA Nobuyuki (30157622)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. KOHSAKA Hitoshi (00251554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 長谷川久紀 (00707028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Mizoguchi Fumitaka 溝口 史高

MIZOGUCHI Fumitaka 溝口 史高

Research Projects

Research Products

Co-Researchers

多発性筋炎/皮膚筋炎の筋組織の免疫表現型解析による病態解明と疾患再分類への挑戦Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new therapeutic strategies targeting rheumatoid arthritis-associated fibroblast subsetPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

microRNA as a target to develop a novel treatment for rheumatoid arthritis and to clarify a new pathology in rheumatoid arthritis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of the origin of pathogenic synovial fibroblasts in rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new anti-rheumatic drugs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of miRNA as therapeutic target in rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 骨に関わる主な疾病発症のメカニズム 第2章 関節リウマチ. 骨研究最前線2013

Author(s)

Data Source

[Journal Article] Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RA 骨破壊のメカニズム2013

Author(s)

Journal Title

Data Source

[Journal Article] Hypoxia-induced Abrogation of Contact-dependent Inhibition of Rheumatoid Arthritis Synovial Fibroblast Proliferation2009

Author(s)

Journal Title

Data Source

[Presentation] シングルセル解析による線維芽細胞亜群の同定と関節リウマチの病態解析2018

Author(s)

Organizer

Data Source

[Presentation] シングルセル解析による線維芽細胞サブセットの同定と関節リウマチの病態解析2017

Author(s)

Organizer

Data Source

[Presentation] 関節リウマチ滑膜病理の脱構築による病態解析2017

Author(s)

Organizer

Data Source

[Presentation] IL6を高産生する線維芽細胞サブセットを制御する転写因子の同定2017

Author(s)

Organizer

Data Source

[Presentation] 関節リウマチの病態を担う新規線維芽細胞サブセットの同定2017

Author(s)

Mizoguchi Fumitaka 溝口史高

MIZOGUCHI Fumitaka 溝口史高

[Book] 骨に関わる主な疾病発症のメカニズム第2章関節リウマチ. 骨研究最前線2013

[Presentation] 転写抑制因子ets variant 6の発現を抑制するmicroRNAの阻害は、関節リウマチ滑膜線維芽細胞からの matrix metalloproteinase-3とinterleukin-6産生を抑制する