Negishi Hideo 根岸英雄

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NEGISHI Hideo 根岸英雄

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Researcher Number	60514297
Other IDs
Affiliation (Current)	2025: 東京大学, 定量生命科学研究所, 特任講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 東京大学, 定量生命科学研究所, 特任講師 2021 – 2022: 東京大学, 医科学研究所, 特任講師 2012 – 2019: 東京大学, 生産技術研究所, 特任助教 2014: 東京大学, 生産技術研究所, 助教 2012: 東京大学, 生産技術研究所, 助教 2010 – 2011: The University of Tokyo, 大学院・医学系研究科, 助教 2009: The University of Tokyo, 大学院・医学系研究科, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Complex systems / Experimental pathology / Virology Except Principal Investigator Immunology / Biological Sciences
Keywords	Principal Investigator 核酸 / RNA / 自然免疫 / 内在性RNA / DNA / 炎症 / TLR / 細胞死 / I型IFN / サイトカイン … More / 自己免疫 / DAMPs / 低分子化合物 / 抗がん剤 / がん / 免疫性核酸 / CVB3 / II型IFN … More Except Principal Investigator 炎症 / 自己免疫疾患 / 自然免疫 / 炎症・がん / DAMP / 免疫原性核酸 / がん / HMGB1 / 自然免疫受容体 / 恒常性維持 / 免疫シグナル伝達 / 核酸 / 自己由来分子 / 感染 / 核酸認識システム / 制がんベクトル / 発がんスパイラル Less

内在性炎症性RNAの実態と免疫疾患発症・増悪機構の解明Principal Investigator
- Principal Investigator
  
  根岸英雄
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  The University of Tokyo
Analysis of endogenous RNA related to autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  Negishi Hideo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  The University of Tokyo
自己由来分子による炎症･免疫応答系の制御機構の解明
- Principal Investigator
  
  谷口維紹
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Elucidation of the host's homeostatic responses by the regulation of immune system and its application to the prevention and treatment of immunological disorders
- Principal Investigator
  
  Taniguchi Tadatsugu
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
新規低分子化合物を用いたがん抑制機構の解析Principal Investigator
- Principal Investigator
  
  根岸英雄
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
Identification of immunogenic nucleic acid-protein complexPrincipal Investigator
- Principal Investigator
  
  NEGISHI Hideo
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokyo
Elucidation and control of the carcinogenic spiral that results from inflammation and immune responses
- Principal Investigator
  
  TANIGUCHI Tadatsugu
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
The regulation mechanism of TLR3 dependent type II IFN responsePrincipal Investigator
- Principal Investigator
  
  NEGISHI Hideo
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Virology
- Research Institution
  The University of Tokyo

All 2019 2018 2017 2016 2015 2014 2013 2012

All Journal Article

[Journal Article] Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis.2019
- Author(s)
  Negishi H, Endo N, Nakajima Y, Nishiyama T, Tabunoki Y, Nishio J, Koshiba R, Matsuda A, Matsuki K, Okamura T, Negishi-Koga T, Ichinohe T, Takemura S, Ishiwata H, Iemura SI, Natsume T, Abe T, Kiyonari H, Doi T, Hangai S, Yanai H, Fujio K, Yamamoto K, Taniguchi T.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 116 Issue: 47 Pages: 23653-23661
- DOI
  10.1073/pnas.1915326116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07166, KAKENHI-PROJECT-18K07167, KAKENHI-PROJECT-18K15179, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-19H03697, KAKENHI-PROJECT-17H04050
[Journal Article] Novel chemical compound SINCRO with dual function in STING-type I interferon and tumor cell death pathways2018
- Author(s)
  Kimura Yoshitaka、Negishi Hideo、Matsuda Atsushi、Endo Nobuyasu、Hangai Sho、Inoue Asuka、Nishio Junko、Taniguchi Tadatsugu、Yanai Hideyuki
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 9 Pages: 2687-2696
- DOI
  10.1111/cas.13726
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15179, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18K07167
[Journal Article] Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice2018
- Author(s)
  Yanai Hideyuki、Chiba Shiho、Hangai Sho、Kometani Kohei、Inoue Asuka、Kimura Yoshitaka、Abe Takaya、Kiyonari Hiroshi、Nishio Junko、Taguchi-Atarashi Naoko、Mizushima Yu、Negishi Hideo、Grosschedl Rudolf、Taniguchi Tadatsugu
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 20 Pages: 5253-5258
- DOI
  10.1073/pnas.1803936115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15179, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18K07167
[Journal Article] Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis2017
- Author(s)
  Sarashina-Kida H、Negishi H、Nishio J、Suda W、Nakajima Y、Yasui-Kato M、Iwaisako K、Kang S、Endo N、Yanai H、Asagiri M、Kida H、Hattori M、Kumanogoh A、Taniguchi T
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 114 Issue: 38 Pages: 10178-10183
- DOI
  10.1073/pnas.1712837114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09537, KAKENHI-PROJECT-15H05787
[Journal Article] The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family.2017
- Author(s)
  Negishi, H., Taniguchi, T., Yanai, H.
- Journal Title
  
  Cold Spring Harb Perspect Biol.
  
  Volume: - Issue: 11 Pages: a028423-a028423
- DOI
  10.1101/cshperspect.a028423
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18K07167
[Journal Article] S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification.2016
- Author(s)
  Teijaro J. R., Studer S., Leaf N., Kiosses, W.B., Nguyen N., Matsuki K., Negishi H., Taniguchi T., Oldstone M.B.A., and Rosen H.
- Journal Title
  
  Proc. Natl. Acad. Sci. U S A.
  
  Volume: 113 Issue: 5 Pages: 1351-6
- DOI
  10.1073/pnas.1525356113
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787
[Journal Article] PGE2 induced in and released by dying cells functions as an inhibitory DAMP.2016
- Author(s)
  Hangai S, Ao T, Kimura Y, Matsuki K, Kawamura T, Negishi H, Nishio J, Kodama T, Taniguchi T, Yanai H.
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 113 Issue: 14 Pages: 3844-3849
- DOI
  10.1073/pnas.1602023113
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J12292, KAKENHI-PROJECT-14J04316, KAKENHI-PROJECT-15H05787
[Journal Article] The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.2016
- Author(s)
  Kimura Y., Inoue A.., Hangai S.., Saijo S., Negishi H., Nishio J., Yamasaki S., Iwakura Y., Yanai H., Taniguchi T.
- Journal Title
  
  Proc. Natl. Acad. Sci. U S A.
  
  Volume: 113 Issue: 49 Pages: 14097-14102
- DOI
  10.1073/pnas.1617903113
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-16H06747, KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-16K15271
[Journal Article] Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis2015
- Author(s)
  Nishio J, et al.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 112 Issue: 41 Pages: 12770-12775
- DOI
  10.1073/pnas.1516617112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04747, KAKENHI-PROJECT-14F04416, KAKENHI-PROJECT-15H05787
[Journal Article] Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.2014
- Author(s)
  Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T.
- Journal Title
  
  eLife
  
  Volume: 04177 Pages: 04177-04177
- DOI
  10.7554/elife.04177
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-12J04120, KAKENHI-PROJECT-13J05883, KAKENHI-PROJECT-14F04416, KAKENHI-PROJECT-14J04316, KAKENHI-PROJECT-14J12292, KAKENHI-PLANNED-22114007, KAKENHI-PROJECT-23390101, KAKENHI-PROJECT-24590574, KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-26860316
[Journal Article] Conditional ablation of HMGB 1 in mice reveals its protective function a gainst endotoxemia and bacterial infection2013
- Author(s)
  Yanai, H, et al.
- Journal Title
  
  Proc. Natl. Acad. Sci. U S A.
  
  Volume: 51 Issue: 51 Pages: 20699-20704
- DOI
  10.1073/pnas.1320808110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J04258, KAKENHI-PLANNED-22114007, KAKENHI-PROJECT-23590563, KAKENHI-PROJECT-24590574, KAKENHI-PROJECT-25462008
[Journal Article] The IRF family transcription factors at the interface of innate and adaptive immune responses.2013
- Author(s)
  Ikushima, H., Negishi, H., and Taniguchi, T.
- Journal Title
  
  Cold Spring Harbor Symposia on Quantitative Biology
  
  Volume: LXXVIII Issue: 0 Pages: 105-116
- DOI
  10.1101/sqb.2013.78.020321
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114007
[Journal Article] Beneficial innate signaling interference for anti-bacterial responses by a TLR-mediated enhancement of the MKP-IRF3 axis.2013
- Author(s)
  Negishi H, Matsuki K, Endo N, Sarashina H, Miki S, Matsuda A, Fukazawa K , Taguchi-Atarashi N, Ikushima H, Yanai H, Nishio J, Honda K, Fujioka Y, Ohba Y, Noda T, Taniguchi S, Nishida E, Zhang Y, Chi H, Flavell RA, Taniguchi T.
- Journal Title
  
  roc. Natl. Acad. Sci. USA.
  
  Volume: 49 Pages: 19884-9
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114007
[Journal Article] Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cellresponses2012
- Author(s)
  Negishi, H., et al.
- Journal Title
  
  Nature Immunology
  
  Volume: 13 Issue: 7 Pages: 659-666
- DOI
  10.1038/ni.2307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J04258, KAKENHI-PROJECT-24590574, KAKENHI-PLANNED-22114007
[Journal Article] Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp gene induction2012
- Author(s)
  Hideo Negishi, Shoji Miki, Hana Sarashina, Naoko Taguchi-Atarashi, Akira Nakajima, Kosuke Matsuki, Nobuyasu Endo, Hideyuki Yanai, Junko Nishio, Kenya Honda, and Tadatsugu Taniguchi
- Journal Title
  
  PNAS
  
  Volume: 109(51) Issue: 51 Pages: 21016-21021
- DOI
  10.1073/pnas.1219482110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05380, KAKENHI-PROJECT-23590563, KAKENHI-PROJECT-24590574, KAKENHI-PLANNED-22114007

1. TANIGUCHI Tadatsugu (50133616)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
2. YANAI Hideyuki (70431765)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. 西尾純子 (40598679)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 岩倉洋一郎 (10089120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 藤尾圭志 (70401114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 山本一彦 (80191394)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 生島弘彬 (80719154)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KIDA Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 半谷匠

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Negishi Hideo 根岸 英雄

NEGISHI Hideo 根岸 英雄

Research Projects

Research Products

Co-Researchers

内在性炎症性RNAの実態と免疫疾患発症・増悪機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of endogenous RNA related to autoimmune diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

自己由来分子による炎症･免疫応答系の制御機構の解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the host's homeostatic responses by the regulation of immune system and its application to the prevention and treatment of immunological disorders

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新規低分子化合物を用いたがん抑制機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of immunogenic nucleic acid-protein complexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation and control of the carcinogenic spiral that results from inflammation and immune responses

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The regulation mechanism of TLR3 dependent type II IFN responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel chemical compound SINCRO with dual function in STING-type I interferon and tumor cell death pathways2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification.2016

Author(s)

Negishi Hideo 根岸英雄

NEGISHI Hideo 根岸英雄