Kunishige Tomoyuki 國重智之

Researcher Number	60516045
Other IDs
Affiliation (Current)	2025: 日本医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 日本医科大学, 医学部, 准教授 2018 – 2020: 日本医科大学, 医学部, 講師 2014 – 2017: 日本医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 56060:Ophthalmology-related / Ophthalmology Except Principal Investigator Basic Section 56060:Ophthalmology-related / Ophthalmology / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Keywords	Principal Investigator 免疫抑制性眼内微小環境 / VISTA / 免疫特権 / ACAID / 角膜移植 / 副刺激シグナル / 副刺激分子シグナル / 免疫学 / 血管新生 / ICOS … More Except Principal Investigator … More 免疫特権 / 拒絶反応 / 角膜移植 / 免疫チェックポイント / 網羅的サイトカイン解析 / 角膜炎症 / 眼免疫特権 / ICOS / TIM4 / 血管リンパ管新生 / 移植 / 眼炎症 / 免疫制御 / ACAID / 副刺激シグナル / ヒト培養角膜内皮細胞 / 再生医療 / 角膜内皮移植 / 強膜炎 / 制御性T細胞 / ICOSL / 移植拒絶反応 / 炎症 / 再生 / 移植拒絶反応制御 / 免疫抑制 / 移植後拒絶反応 / TIM-4 / 免疫寛容 / 移植免疫 / VISTA / ICOS/B7RP-1 / VISTAシグナル / ICOS/B7RP-1(ICOSL) / 移植免疫応答 Less

Translational research on the pathogenesis of corneal endothelial cell loss in corneal endothelial transplantation and regenerative medicine through immunoregulation
- Principal Investigator
  
  堀純子
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Nippon Medical School
Analysis of ocular immune checkpoints for novel treatment of ocular tissue transplantation and ocular inflammatory diseases
- Principal Investigator
  
  堀純子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Nippon Medical School
Analysis of Molecular Mechanisms Contributing to Ocular Immune Privilege and Regulatory T Cells for Transplantation and Treatment of Ocular Inflammatory Diseases
- Principal Investigator
  
  HORI JUNKO
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Nippon Medical School
Contribution of VISTA molecules to corneal transplantation and immune privilegePrincipal Investigator
- Principal Investigator
  
  Kunishige Tomoyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Nippon Medical School
Analysis of ocular immune checkpoints to develop new therapy for transplantation and inflammatory diseases in the eye
- Principal Investigator
  
  Hori Junko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Nippon Medical School
Role of ICOS on Corneal LymphangiogenesisPrincipal Investigator
- Principal Investigator
  
  Kunishige Tomoyuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Nippon Medical School
Immune regulation for tissue transplantation and regeneration in the eye
- Principal Investigator
  
  Hori Junko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Nippon Medical School

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Immune Checkpoints Contribute Corneal Immune Privilege: Implications for Dry Eye Associated with Checkpoint Inhibitors2020
- Author(s)
  Hori Junko、Kunishige Tomoyuki、Nakano Yuji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 11 Pages: 3962-3975
- DOI
  10.3390/ijms21113962
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09813
[Journal Article] VISTA Is Crucial for Corneal Allograft Survival and Maintenance of Immune Privilege2019
- Author(s)
  Kunishige T,Taniguchi H, Ohno T, Azuma M, Hori J
- Journal Title
  
  Invest Ophthalmol Vis Sci.
  
  Volume: 60 Issue: 15 Pages: 4958-4965
- DOI
  10.1167/iovs.19-27322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11493
[Journal Article] vogt-小柳-原田病の再発と治療内容に関する検討2018
- Author(s)
  白鳥宙、國重智之、由井智子、堀純子
- Journal Title
  
  あたらしい眼科
  
  Volume: 35
- NAID
  40021585988
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11493
[Journal Article] 角膜移植後免疫応答にみる眼内微小環境の特殊性2016
- Author(s)
  國重智之、堀純子
- Journal Title
  
  医学のあゆみ
  
  Volume: 256(13) Pages: 1259-1261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462700
[Journal Article] 角膜移植後免疫応答にみる眼内微小環境の特殊性2016
- Author(s)
  國重智之　堀純子
- Journal Title
  
  医学のあゆみ
  
  Volume: 256 Pages: 1259-1961
- Data Source
  KAKENHI-PROJECT-15K20290
[Journal Article] Protective role of ICOS and ICOS Ligand in corneal transplantation and in maintenance of immune privilege2016
- Author(s)
  Kunishige T, Taniguchi H, Terada M, Akiba H, Yagita H, Abe R, Hori J
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 57(15) Issue: 15 Pages: 6815-6823
- DOI
  10.1167/iovs.16-20644
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462700, KAKENHI-PROJECT-15K20290, KAKENHI-PROJECT-16K09924
[Presentation] 抗原非特異的炎症時の角膜血管リンパ管新生におけるICOSの役割とその関連因子.2023
- Author(s)
  仲野裕一郎、山本恵、山口剛史、國重智之、堀純子.
- Organizer
  第127回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-23K09016
[Presentation] 抗原非特異的炎症時の角膜血管リンパ管新生におけるICOSの役割とその関連因子2023
- Author(s)
  仲野裕一郎, 山本恵, 山口剛史, 國重智之, 堀純子
- Organizer
  第127回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-20K09813
[Presentation] 抗原非特異的な炎症時の角膜血管リンパ管新生における角膜内サイトカインの変化2022
- Author(s)
  仲野裕一郎, 武田彩佳, 國重智之, 山本恵, 寺田節, 丸山和一, 山口剛史, 堀純子
- Organizer
  第126回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-20K09813
[Presentation] VISTA is crucial for corneal allograft survival and immune privilege2021
- Author(s)
  Tomoyuki Kunishige, Tatsukuni Ohno, Miyuki Azuma, Junko Hori
- Organizer
  The 7th Asia Cornea Society Biennial Scientific Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18362
[Presentation] 眼の免疫特権における新規の免疫チェックポイント分子の役割2021
- Author(s)
  國重智之
- Organizer
  第54回日本眼炎症学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K18362
[Presentation] 後部強膜炎に対する生物学的製剤の使用～背景疾患による薬剤選択と効果の違い～2020
- Author(s)
  西尾侑祐、武田彩佳、國重智之、桑名正隆、堀純子
- Organizer
  第5回東京眼炎症セミナー
- Data Source
  KAKENHI-PROJECT-20K09813
[Presentation] アダリムマブが著効した間質性腎炎ぶどう腸炎症候群の一卵性双生児2018
- Author(s)
  武田彩佳、國重智之、五十嵐徹、堀純子
- Organizer
  Annual Meeting of the Japanese Ophthalmological Society
- Invited
- Data Source
  KAKENHI-PROJECT-17K11493
[Presentation] 正常角膜と移植角膜におけるTim-4の発現2018
- Author(s)
  A Takeda, T Kunishige, H Akiba, H Yagita, J Hori
- Organizer
  第55回日本眼炎症学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11493
[Presentation] 硝子体液IL-6の高値により診断に苦慮した眼内原発悪性リンパ腫の一例2018
- Author(s)
  窪倉真樹子、由井智子、國重智之、堀純子
- Organizer
  Annual Meeting of the Japanese Ophthalmological Society
- Invited
- Data Source
  KAKENHI-PROJECT-17K11493
[Presentation] 原発性眼内悪性リンパ腫の診断にIgH遺伝子再構成PCRが有用であった3症例2018
- Author(s)
  M Kubokura,A Takeda, T Kunishige, E Takahashi, H Takahashi, J Hori
- Organizer
  第74回日本臨床眼科学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11493
[Presentation] Expression of Tcell/transmembrane,immunoglobulin,and mucin(TIM)-4 in normal cornea and corneal grafts2018
- Author(s)
  A Takeda,H Taniguchi,T Kunishige,H Akiba,H Yagita ,J Hori
- Organizer
  ARVO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11493
[Presentation] 角膜移植の生着におけるV-domain Ig suppressor of T cell activation (VISTA)の役割2017
- Author(s)
  國重智之、谷口ヒロ子、大野建州、東みゆき、堀　純子
- Organizer
  第４回日本医科大学・東京理科大学合同シンポジウム
- Data Source
  KAKENHI-PROJECT-17K11493
[Presentation] Role of V-domain Ig suppressor of T cell activation (VISTA) in Anterior Chamber Associated Immune Deviation2016
- Author(s)
  T Kunishige, H Taniguchi, T Ohno, M Azuma, J Hori.
- Organizer
  ARVO
- Place of Presentation
  Seattle, USA
- Year and Date
  2016-05-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] Expression of ICOS and Foxp3 on T cells infiltrating in corneal allografts2016
- Author(s)
  H Taniguchi, T Kunishige, H Akiba, H Yagita, R Abe, J Hori
- Organizer
  ARVO
- Place of Presentation
  Seattle, USA
- Year and Date
  2016-05-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] Role of V-domain Ig suppressor of T cell activation (VISTA) in Anterior Chamber Associated Immune Deviation2016
- Author(s)
  T Kunishige, H Taniguchi, T Ohno, M Azuma, J Hori
- Organizer
  ARVO 2016 (The Association for Research in Vision and Ophthalmology)
- Place of Presentation
  Seattle, WA, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] Expression of ICOS and Foxp3 on T cells infiltrating in corneal allografts2016
- Author(s)
  H Taniguchi, T Kunishige, H Akiba, H Yagita, R Abe, J Hori
- Organizer
  ARVO 2016 (The Association for Research in Vision and Ophthalmology)
- Place of Presentation
  Seattle, WA, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] Expression of ICOS and Foxp3 on T cells infiltrating in corneal allografts2016
- Author(s)
  Hiroko Taniguchi, Kunishige Tomoyuki, Hisaya Akiba, Hideo Yagita, Abe, Ryo, Junko Hori
- Organizer
  Association for Research in Vision and Ophthalmology (ARVO) 016
- Place of Presentation
  Seattle, WA, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20290
[Presentation] 角膜移植免疫とV-domain Ig suppressor of T cell activation (VISTA)2015
- Author(s)
  國重智之、堀純子
- Organizer
  眼免疫研究会
- Place of Presentation
  東京
- Year and Date
  2015-06-19
- Invited
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] マウス角膜移植におけるICOS/ICOS-Lの役割2015
- Author(s)
  國重智之, 谷口ヒロ子, 大野建州, 東みゆき, 堀純子
- Organizer
  Tokyo Ocular immunology meeting
- Place of Presentation
  東京
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-15K20290
[Presentation] The V-domain Ig suppressor of T cell activation (VISTA) plays an essential role in the acceptance of corneal allografts2015
- Author(s)
  T Kunishige, H Taniguchi, T Ohno, M Azuma, J Hori
- Organizer
  Asia-ARVO (The Association for Research in Vision and Ophthalmology)
- Place of Presentation
  Yokohama
- Year and Date
  2015-02-17
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] Mechanisms of V-domain Ig suppressor of T cell activation (VISTA)-mediated acceptance of corneal allografts.2015
- Author(s)
  Tomoyuki Kunishige, H Taniguchi, T Ohno, M Azuma, J Hori.
- Organizer
  ARVO
- Place of Presentation
  Denver, CO, USA
- Year and Date
  2015-05-06
- Data Source
  KAKENHI-PROJECT-15K20290
[Presentation] Mechanisms of V-domain Ig suppressor of T cell activation (VISTA)-mediated acceptance of corneal allografts2015
- Author(s)
  T Kunishige, H Taniguchi, T Ohno, M Azuma, J Hori
- Organizer
  The Association for Research in Vision and Ophthalmology
- Place of Presentation
  Denver, USA
- Year and Date
  2015-05-06
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] Mechanisms of V-domain Ig suppressor of T cell activation (VISTA)-mediated acceptance of corneal allografts2015
- Author(s)
  T Kunishige, H Taniguchi, T Ohno, M Azuma, J Hori
- Organizer
  ARVO(The Association for Research in Vision and Ophthalmology)
- Place of Presentation
  Denver, CO, USA
- Year and Date
  2015-05-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] マウス角膜移植におけるICOS/ICOS-Lの役割2015
- Author(s)
  T Kunishige, J Hori
- Organizer
  Tokyo Ocular immunology meeting
- Place of Presentation
  東京
- Year and Date
  2015-09-11
- Invited
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] The V-domain Ig suppressor of T cell activation (VISTA) plays an essential role in the acceptance of corneal allografts2014
- Author(s)
  T Kunishige, H Taniguchi, T Ohno, M Azuma, J Hori
- Organizer
  ISER
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-07-21
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] 角膜移植移植におけるV-domain Igsuppressor of T cell activation (VISTA)の役割2014
- Author(s)
  國重智之、谷口ヒロ子、大野建洲、東みゆき、堀純子
- Organizer
  第48回日本眼炎症学会
- Place of Presentation
  東京
- Year and Date
  2014-07-04
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] Role of V-Domain Ig Suppressor of T Cell Activation (VISTA) on Immune Privilege of Corneal Allograft
- Author(s)
  T Kunishige, H Taniguchi, T Ohno, M Azuma, J Hori
- Organizer
  WOC (World Ophthalmology Congress)
- Place of Presentation
  Tokyo
- Year and Date
  2014-04-02 – 2014-04-06
- Data Source
  KAKENHI-PROJECT-26462700

1. Hori Junko (60251279)

# of Collaborated Projects: 5 results

# of Collaborated Products: 27 results
2. 谷口ヒロ子 (00535445)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
3. 武田彩佳 (20804610)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. 仲野裕一郎 (70867978)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. Azuma Miyuki (90255654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. Abe Ryo (20159453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. Yagita Hideo (30182306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. Akiba Hisaya (60338316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 薫一帆 (80740563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 須賀亮太 (80987066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 田内睦大 (90987067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kunishige Tomoyuki 國重 智之

Research Projects

Research Products

Co-Researchers

Translational research on the pathogenesis of corneal endothelial cell loss in corneal endothelial transplantation and regenerative medicine through immunoregulation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of ocular immune checkpoints for novel treatment of ocular tissue transplantation and ocular inflammatory diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of Molecular Mechanisms Contributing to Ocular Immune Privilege and Regulatory T Cells for Transplantation and Treatment of Ocular Inflammatory Diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Contribution of VISTA molecules to corneal transplantation and immune privilegePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of ocular immune checkpoints to develop new therapy for transplantation and inflammatory diseases in the eye

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of ICOS on Corneal LymphangiogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Immune regulation for tissue transplantation and regeneration in the eye

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Immune Checkpoints Contribute Corneal Immune Privilege: Implications for Dry Eye Associated with Checkpoint Inhibitors2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] VISTA Is Crucial for Corneal Allograft Survival and Maintenance of Immune Privilege2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] vogt-小柳-原田病の再発と治療内容に関する検討2018

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 角膜移植後免疫応答にみる眼内微小環境の特殊性2016

Author(s)

Journal Title

Data Source

[Journal Article] 角膜移植後免疫応答にみる眼内微小環境の特殊性2016

Author(s)

Journal Title

Data Source

[Journal Article] Protective role of ICOS and ICOS Ligand in corneal transplantation and in maintenance of immune privilege2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] 抗原非特異的炎症時の角膜血管リンパ管新生におけるICOSの役割とその関連因子.2023

Author(s)

Organizer

Data Source

[Presentation] 抗原非特異的炎症時の角膜血管リンパ管新生におけるICOSの役割とその関連因子2023

Author(s)

Kunishige Tomoyuki 國重智之