Watanabe Takayoshi 渡部隆義

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WATANABE Takayoshi 渡部隆義

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Researcher Number	60526060
Affiliation (Current)	2025: 千葉県がんセンター(研究所), 発がん制御研究部, 研究員
Affiliation (based on the past Project Information) *help	2025: 千葉県がんセンター(研究所), 発がん制御研究部, 研究員 2018 – 2023: 千葉県がんセンター(研究所), がん研究開発グループ, 研究員 2012 – 2017: 千葉県がんセンター(研究所), がん遺伝創薬研究室, 研究員 2016: 千葉県がんセンター, 研究所, 研究員 2015: 千葉県がんセンター研究所, がん遺伝創薬研究室, 研究員 … More 2011: 千葉県がんセンター(研究所), 研究員 2011: 日本大学, 理工学部, 研究所研究員 2011: 日本大学, 理工学部・物質応用化学科, 研究員 2010: 日本大学, 医学部, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Medical genome science / Tumor therapeutics / General medical chemistry Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Pediatrics / Basic Section 52040:Radiological sciences-related / Basic Section 49010:Pathological biochemistry-related / Chemical biology / Gastroenterology / Tumor therapeutics / Carcinogenesis
Keywords	Principal Investigator PIポリアミド / アルキル化剤 / ピロールイミダゾールポリアミド / KRAS / 受精鶏卵 / MYCN / アミノ基 / PIP-CBI / hTERT / 膵線管がん … More / ゲノム創薬 / ゲノム医学 / ゲノム科学 / 総合生物 / 膵臓がん / KR12 / 膵線管癌 / γアミノ酪酸 / βアラニン / ドライバーオンコジーン / CBI / PIP / 変異型ドライバーオンコジーン / ピロール・イミダゾールポリアミド / ブロックユニット / PEG-HMPB-レジン / リシンテール / 環状PIポリアミド / 水溶性の向上 / 遺伝子発現抑制 / ABCA1 / ポリアミドブロック / ユニーク型PIポリアミド / 固相合成法 … More Except Principal Investigator PIポリアミド / 遺伝子増幅 / ケミカルバイオロジー / 増幅遺伝子 / 肺がん / 遺伝子 / KRAS / アルキル化剤 / mtDNA 変異 / ミトコンドリアDNA / MELAS / ミトコンドリア病 / 病因性ミトコンドリアDNA / 癌 / エピジェネティクス / がん / ピロールイミダゾールポリアミド / MET / オルガノイド / LCNEC / SCLC / Stathmin-1 / 大細胞性神経内分泌腫瘍 / 肺小細胞癌 / パクリタキセル / 微小管 / スタスミン / 小細胞癌 / ピロールイミダゾームポリアミド / STMN1 / 神経内分泌腫瘍 / タキサン系抗がん剤 / PIP化合物 / Stathmin 1 / 高悪性度肺神経内分泌腫瘍 / 肺癌 / 放射線増感剤 / 低酸素細胞 / 放射線治療 / UCHL1 / シスプラチン / オキソプラチン / 標的治療 / ピロール・イミダゾール・ポリアミド化合物 / 変異mtDNA / がん増殖抑制 / TPP / malignancy / cancer / mutated mtDNA / Triphenylphosphonium / PI polyamide / SNP / 子宮癌 / 病原性mtDNA変異 / 子宮がん / PIP-TPP / mtDNA / ピロール-イミダゾールポリアミド / ピロール・イミダゾールポリアミド / エピゲノム制御 / DNA配列認識 / ヒストンメチル化 / エピゲノム / 発現制御 / 核酸化学 / ピロール・イミダゾール・ポリアミド / 変異 / DNA / ミトコンドリア / A3243G変異 / A3243G / トランスレーショナルリサーチ / ピロールイミダゾール含有ポリアミド / リッキドバイオプシー / 大腸がん / リキッドバイオプシー / ctDNA / KRAS変異 / 分子標的治療 / 抗がん剤 / ゲノム / 薬学 / 抗生物質 / 免疫チェックポイント阻害 / マイナーグルーブバインダー / DNA配列認識化合物 / 変異遺伝子標的治療 / がんドライバー遺伝子変異 / 抗癌治療薬 / DNA副溝結合化合物 / 遺伝子変異 / ドライバー遺伝子 / 疾患特異的mtDNA変異 / PI ポリアミド / PIポリアミドFITC修飾 / cybrid / mtDNA異常 / ミットコンドリア病 / 内在性遺伝子の再発現 / 山中因子 / SAHA / iPS細胞 / リプログラミング / エピジェネティク / ヒストン修飾 / ヒストン脱アセチル化酵素阻害剤 / ヒストンアセチル化 Less

p300/CBP/PCAF・ HAT抑制法による難治性大腸癌の革新的治療戦略の構築Principal Investigator
- Principal Investigator
  
  渡部隆義
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Development of amplified gene-specific alkylator as a novel therapeutic agent using patient-derived organoids from solid tumors
- Principal Investigator
  
  高取敦志
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Exploring the potential of PIP-CBI derivatives with amino groups as anticancer agents for drug discoveryPrincipal Investigator
- Principal Investigator
  
  WATANABE TAKAYOSHI
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Chiba Cancer Center (Research Institute)
PIポリアミドによる低酸素細胞に対する放射線増感剤の開発
- Principal Investigator
  
  石橋直也
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Nihon University
Tumor growth suppression by PIP targeting against mutated mtDNAs
- Principal Investigator
  
  Koshikawa Nobuko
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Development of amplified gene-selective alkylator as a novel cancer therapeutic agent
- Principal Investigator
  
  Takatori Atsushi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Development of a new treatment for high-grade neuroendocrine carcinoma of the lung targeting Stathmin1
- Principal Investigator
  
  Shimizu Kimihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Shinshu University
Development of therapeutic strategy using molecules of targeting genomic mutation for pancreatic ductal carcinomaPrincipal Investigator
- Principal Investigator
  
  Watanabe Takayoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical genome science
- Research Institution
  Chiba Cancer Center (Research Institute)
Development of highly sensitive genotyping method by blood circulating tumor DNA enrichment using PIP polyamide
- Principal Investigator
  
  Denda Tadamichi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba Cancer Center (Research Institute)
Target therapy of pathogenic mtDNA mutation with PI polyamide
- Principal Investigator
  
  Koshikawa Nobuko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Chiba Cancer Center (Research Institute)
Development of Alkylating PI polyamides targeting oncogenic driver gene mutations
- Principal Investigator
  
  Nagase Hiroki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Chiba Cancer Center (Research Institute)
Selective modification of histone methylation using DNA binding-small molecules
- Principal Investigator
  
  Shinohara Ken-ichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Chiba University
Study of mitochondria-associated diseases by pathogenic mitochondrial DNA replication delay
- Principal Investigator
  
  Koshikawa Nobuko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Chiba Cancer Center (Research Institute)
Development of anticancer drug specifically targeting oncogenic driver mutationsPrincipal Investigator
- Principal Investigator
  
  WATANABE Takayoshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Chiba Cancer Center (Research Institute)
Development of cancer therapy inducing histone acethylation at the specific region of cancer genome
- Principal Investigator
  
  NAGASE Hiroki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Carcinogenesis
- Research Institution
  Chiba Cancer Center (Research Institute)
Development of Noble Structure PI Polyamide Recognizing to a Unique Sequence on double-strand DNAPrincipal Investigator
- Principal Investigator
  
  WATANABE Takayoshi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Nihon University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Patent

[Journal Article] Suppression of NSCLC A549 tumor growth by a mtDNA mutation‐targeting pyrrole‐imidazole polyamide‐TPP and a senolytic drug2022
- Author(s)
  Tsuji Kohei、Kida Yuki、Koshikawa Nobuko、Yamamoto Seigi、Shinozaki Yoshinao、Watanabe Takayoshi、Lin Jason、Nagase Hiroki、Takenaga Keizo
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 4 Pages: 1321-1337
- DOI
  10.1111/cas.15290
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-20K07710, KAKENHI-PROJECT-19K07654, KAKENHI-PROJECT-22H04923
[Journal Article] Anticancer effect of a pyrrole‐imidazole polyamide‐triphenylphosphonium conjugate selectively targeting a common mitochondrial DNA cancer risk variant in cervical cancer cells2022
- Author(s)
  Yao Jihang、Takenaga Keizo、Koshikawa Nobuko、Kida Yuki、Lin Jason、Watanabe Takayoshi、Maru Yoshiaki、Hippo Yoshitaka、Yamamoto Seigi、Zhu Yuyan、Nagase Hiroki
- Journal Title
  
  International Journal of Cancer
  
  Volume: 152 Issue: 5 Pages: 962-976
- DOI
  10.1002/ijc.34319
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08019, KAKENHI-PROJECT-21K09506, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-19K07654, KAKENHI-PROJECT-20K07710, KAKENHI-PROJECT-21K14756, KAKENHI-PROJECT-22H04923
[Journal Article] Use of DNA‐alkylating pyrrole‐imidazole polyamides for anti‐cancer drug sensitivity screening in pancreatic ductal adenocarcinoma2022
- Author(s)
  Tsujimoto Akiko、Matsuo Niina、Lai Xiaoyi、Inoue Takahiro、Yoda Hiroyuki、Lin Jason、Shinozaki Yoshinao、Watanabe Takayoshi、Koshikawa Nobuko、Takatori Atsushi、Nagase Hiroki
- Journal Title
  
  Cancer Medicine
  
  Volume: 12 Issue: 5 Pages: 5821-5832
- DOI
  10.1002/cam4.5359
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07710
[Journal Article] Targeting the mutant PIK3CA gene by DNA-alkylating pyrrole-imidazole polyamide in cervical cancer2021
- Author(s)
  Krishnamurthy S, Yoda H, Hiraoka K, Inoue T, Lin J, Shinozaki Y, Watanabe T, Koshikawa N, Takatori A, Nagase H
- Journal Title
  
  Cancer Science
  
  Volume: 112(3) Issue: 3 Pages: 1141-1149
- DOI
  10.1111/cas.14785
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07767, KAKENHI-PROJECT-20H03540
[Journal Article] Mitochondria: Endosymbiont bacteria DNA sequence as a target against cancer2021
- Author(s)
  Nagase Hiroki、Watanabe Takayoshi、Koshikawa Nobuko、Yamamoto Seigi、Takenaga Keizo、Lin Jason
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 12 Pages: 4834-4843
- DOI
  10.1111/cas.15143
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-19K07654, KAKENHI-PROJECT-20K07710
[Journal Article] Targeting anaplastic lymphoma kinase (ALK) gene alterations in neuroblastoma by using alkylating pyrrole-imidazole polyamides2021
- Author(s)
  Ota Y, Yoda H, Inoue T, Watanabe T, Shinozaki Y, Takatori A, Nagase H
- Journal Title
  
  PLoS One
  
  Volume: 16(9) Issue: 9 Pages: e0257718-e0257718
- DOI
  10.1371/journal.pone.0257718
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07767, KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-20K07710
[Journal Article] A PI polyamide-TPP conjugate targeting a mtDNA mutation induces cell death of cancer cells with the mutation2021
- Author(s)
  N.Koshikawa N.Yasui Y.Kida Y.Shinozaki K.Tsuji T.Watanabe K.Takenag H.Nagase
- Journal Title
  
  Cancer Science
  
  Volume: 未 Issue: 6 Pages: 1-9
- DOI
  10.1111/cas.14912
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-20K07710, KAKENHI-PROJECT-20H03540
[Journal Article] A linear five-ring pyrrole-imidazole polyamide-triphenylphosphonium conjugate targeting a mitochondrial DNA mutation efficiently induces apoptosis of HeLa cybrid cells carrying the mutation2021
- Author(s)
  Koshikawa Nobuko、Kida Yuki、Yasui Nanami、Shinozaki Yoshinao、Tsuji Kohei、Watanabe Takayoshi、Lin Jason、Yamamoto Seigi、Takenaga Keizo、Nagase Hiroki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 576 Pages: 93-99
- DOI
  10.1016/j.bbrc.2021.08.088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-20K07710
[Journal Article] Enrichment technique to allow early detection and monitor emergence of KRAS mutation in response to treatment.2019
- Author(s)
  Kitagawa Y, Okumura K, Watanabe T, Tsukamoto K, Kitano S, Nankinzan R, Suzuki T, Hara T, Soda H, Denda T, Yamaguchi T, Nagase H.
- Journal Title
  
  Sci Rep.
  
  Volume: 9 Issue: 1 Pages: 11346-11346
- DOI
  10.1038/s41598-019-47700-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17508, KAKENHI-PROJECT-17H03602, KAKENHI-PROJECT-16K09333
[Journal Article] Propensity Score Analysis of Regorafenib Versus Trifluridine/Tipiracil in Patients with Metastatic Colorectal Cancer Refractory to Standard Chemotherapy (REGOTAS): A Japanese Society for Cancer of the Colon and Rectum Multicenter Observational Study.2018
- Author(s)
  Moriwaki T, Fukuoka S, Taniguchi H, Takashima A, Kumekawa Y, Kajiwara T, Yamazaki K, Esaki T, Makiyama C, Denda T, Satake H, Suto T, Sugimoto N, Enomoto M, Ishikawa T, Kashiwada T, Sugiyama M, Komatsu Y, Okuyama H, Baba E, Sakai D, Watanabe T, Tamura T, Yamashita K, Gosho M, Shimada Y.
- Journal Title
  
  Oncologist.
  
  Volume: 23 Issue: 1 Pages: 7-15
- DOI
  10.1634/theoncologist.2017-0275
- NAID
  120007134517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09333
[Journal Article] CEA Response and Depth of Response (DpR) to Predict Clinical Outcomes of First-Line Cetuximab Treatment for Metastatic Colorectal Cancer.2017
- Author(s)
  Sunakawa Y, Tsuji A, Denda T, Segawa Y, Negoro Y, Shimada K, Kochi M, Nakamura M, Kotaka M, Tanioka H, Takagane A, Tani S, Yamaguchi T, Watanabe T, Takeuchi M, Fujii M, Ichikawa W.
- Journal Title
  
  Target Oncol.
  
  Volume: 12 Issue: 6 Pages: 787-794
- DOI
  10.1007/s11523-017-0527-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09333
[Journal Article] Depletion of TFAP2E attenuates adriamycin-mediated apoptosis in human neuroblastoma cells.2017
- Author(s)
  Hoshi R, Watanabe Y, Ishizuka Y, Hirano T, Nagasaki-Maeoka E, Yoshizawa S, Uekusa S, Kawashima H, Ohashi K, Sugito K, Fukuda N, Nagase H, Soma M, Ozaki T, Koshinaga T and Fujiwara K.
- Journal Title
  
  ONCOLOGY REPORTS
  
  Volume: 37 Issue: 4 Pages: 2459-2464
- DOI
  10.3892/or.2017.5477
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290060, KAKENHI-PROJECT-26462718, KAKENHI-PROJECT-15K08412
[Journal Article] Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome.2016
- Author(s)
  Lin J, Hiraoka K, Watanabe T, Kuo T, Shinozaki Y, Takatori A, Koshikawa N, Chandran A, Otsuki J, Sugiyama H, Horton P and Nagase H.
- Journal Title
  
  PlosOne
  
  Volume: 11 Issue: 10 Pages: e0165581-e0165581
- DOI
  10.1371/journal.pone.0165581
- NAID
  120005997725
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01579, KAKENHI-PROJECT-26290060, KAKENHI-PROJECT-15K05486, KAKENHI-ORGANIZER-25112001
[Journal Article] Inhibition of DNA methylation at the MLH1 promoter region using pyrrole-imidazole polyamide.2016
- Author(s)
  Shinohara K, Yoda N, Takane K, Watanabe T, Fukuyo M, Fujiwara K, Kita K, Nagase H, Nemoto T, Kaneda A.
- Journal Title
  
  ACS Omega
  
  Volume: 1 Issue: 6 Pages: 1164-1172
- DOI
  10.1021/acsomega.6b00229
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01579, KAKENHI-PROJECT-26290060, KAKENHI-PROJECT-26350977, KAKENHI-ORGANIZER-25112001, KAKENHI-PROJECT-16K15608
[Journal Article] Double beta-alanine substitutions incorporated in 12-ring pyrrole-Imidazole Polyamides for lengthened DNA minor groove recognition.2016
- Author(s)
  Watanabe T, Shinohara K, Shinozaki Y, Uekusa S, Wang X, Koshikawa N, Hiraoka K, Inoue T, Lin J, Bando T, Sugiyama H and Nagase H.
- Journal Title
  
  Advanced Techniques in Biology & Medicine.
  
  Volume: 4 Issue: 02 Pages: 175-175
- DOI
  10.4172/2379-1764.1000175
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01579, KAKENHI-PROJECT-16J05439, KAKENHI-PROJECT-26290060, KAKENHI-PROJECT-26350977, KAKENHI-ORGANIZER-25112001
[Journal Article] Prognostic Impact of Primary Tumor Location on Clinical Outcomes of Metastatic Colorectal Cancer Treated With Cetuximab Plus Oxaliplatin-Based Chemotherapy: A Subgroup Analysis of the JACCRO CC-05/06 Trials.2016
- Author(s)
  Sunakawa Y, Ichikawa W, Tsuji A, Denda T, Segawa Y, Negoro Y, Shimada K, Kochi M, Nakamura M, Kotaka M, Tanioka H, Takagane A, Tani S, Yamaguchi T, Watanabe T, Takeuchi M, Fujii M, Nakajima T.
- Journal Title
  
  Clin Colorectal Cancer.
  
  Volume: S1533-0028 Issue: 3 Pages: 30204-3
- DOI
  10.1016/j.clcc.2016.09.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09333
[Journal Article] Double β-alanine substitutions incorporated in 12-ring pyrrole-Imidazole Polyamides for lengthened DNA minor groove recognition.2016
- Author(s)
  Watanabe T, Shinohara K, Shinozaki Y, Uekusa S, Wang X, Koshikawa N, Hiraoka K, Inoue T, Lin J, Bando T, Sugiyama H and Nagase H.
- Journal Title
  
  Advanced Techniques in Biology & Medicine.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26290060
[Journal Article] Identification of a novel E-box binding PI polyamide inhibiting MYC-driven cell-proliferation.2015
- Author(s)
  Mishra R, Watanabe T, Kimura M, Koshikawa N, Ikeda M, Uekusa S, Kawashima H, Wang X, Igarashi J, Choudhury D, Grandori C, Kemp C, Ohira M, Verma N, Kobayashi Y, Takeuchi J, Koshinaga T, Nemoto N, Fukuda N, Soma M, Kusafuka T, Fujiwara K, Nagase H.
- Journal Title
  
  Cancer Science
  
  Volume: 106(4) Issue: 4 Pages: 421-429
- DOI
  10.1111/cas.12610
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25134718, KAKENHI-PROJECT-25871150, KAKENHI-PUBLICLY-26112517, KAKENHI-PROJECT-26290060
[Journal Article] Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model.2015
- Author(s)
  Igarashi J, Fukuda N, Inoue T, Nakai S, Saito K, Fujiwara K, Matsuda H, Ueno T, Matsumoto Y, Watanabe T, Nagase H, Bando T, Sugiyama H, Itoh T, Soma M
- Journal Title
  
  PLoS One
  
  Volume: e0125295
- NAID
  120005947168
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25871150
[Journal Article] Pyrrole-Imidazole (PI) polyamide-mediated silencing of KCNQ1OT1 expression induces cell death in Wilms tumor cells.2015
- Author(s)
  Yoshizawa S, Fujiwara K, Sugito K, Uekusa S, Kawashima H, Hoshi R, Watanabe Y, Hirano T, Furuya T, Masuko T, Ueno T, Fukuda N, Soma M, Ozaki T, Koshinaga T, Nagase H.
- Journal Title
  
  International Journal of Oncology
  
  Volume: 47(1) Issue: 1 Pages: 115-121
- DOI
  10.3892/ijo.2015.3018
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25134718, KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-26112517, KAKENHI-PROJECT-26290060
[Journal Article] Inhibition of KRAS Codon 12 Mutants Using a Novel DNA-alkylating Pyrrole-imidazole Polyamide Conjugate2015
- Author(s)
  Hiraoka, K.; Inoue, T.; Taylor, R. D.; Watanabe, T.; Koshikawa, N.; Yoda, H.; Shinohara, K.; Takatori, A.; Sugimoto, K.; Maru, Y.; Denda, T.; Fujiwara, K.; Balmain, A.; Ozaki, T.; Bando, T.; Sugiyama, H.; Nagase, H.
- Journal Title
  
  Nature. Comm.
  
  Volume: in press
- NAID
  120006460100
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26350977
[Journal Article] Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model.2015
- Author(s)
  Igarashi J, Fukuda N, Inoue T, Nakai S, Saito K, Fujiwara K, Matsuda H, Ueno T, Matsumoto Y, Watanabe T, Nagase H, Bando T Sugiyama H Itoh T Soma M.
- Journal Title
  
  PlosOne.
  
  Volume: 10(5) Issue: 5 Pages: e0125295-e0125295
- DOI
  10.1371/journal.pone.0125295
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-26112517, KAKENHI-PROJECT-24310155, KAKENHI-PROJECT-26290060, KAKENHI-PROJECT-24225005
[Journal Article] Pyrrole-imidazole polyamide targeted to break fusion sites in TMPRSS2 and ERG gene fusion represses prostate tumor growth2014
- Author(s)
  Obinata D, Ito Akiko, Fujiwara K, Takayama K, Ashikari D, Murata Y, Yamaguchi K, Urano T, Fujimura T, Fukuda N, Soma M, Watanabe T, Nagase H, Inoue S, Takahashi S
- Journal Title
  
  Cancer Sci
  
  Volume: 105 Issue: 10 Pages: 1272-1278
- DOI
  10.1111/cas.12493
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249040, KAKENHI-PUBLICLY-25134718, KAKENHI-PROJECT-25293214, KAKENHI-PROJECT-25670678, KAKENHI-PROJECT-25871150, KAKENHI-PUBLICLY-26112517, KAKENHI-PROJECT-26290060, KAKENHI-PROJECT-26861302, KAKENHI-PROJECT-221S0001
[Journal Article] Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate.2014
- Author(s)
  Hiraoka K, Inoue T, Taylor RD, Watanabe T, Koshikawa N, Yoda H, Shinohara K, Takatori A, Sugimoto H, Maru Y, Denda T, Fujiwara K, Balmain A, Ozaki T, Bando T, Sugiyama H, Nagase H.
- Journal Title
  
  Nat. Commun.
  
  Volume: 6 Issue: 1 Pages: 6706-6706
- DOI
  10.1038/ncomms7706
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-25134718, KAKENHI-PROJECT-25871150, KAKENHI-PUBLICLY-26112517, KAKENHI-PROJECT-26290060, KAKENHI-PROJECT-15K08412, KAKENHI-PROJECT-26350977, KAKENHI-PROJECT-25461573, KAKENHI-PROJECT-24310155, KAKENHI-PROJECT-24225005
[Journal Article] A novel gene regulator, pyrrole-imidazole polyamide targeting ABCA1 gene increases cholesterol efflux from macrophages and plasma HDL concentration.2014
- Author(s)
  Tsunemi A, Ueno T, Fukuda N, Watanabe T, Tahira K, Haketa A, Hatanaka Y, Tanaka S, Matsumoto T, Matsumoto Y, Nagase H, Soma M.
- Journal Title
  
  J Mol Med
  
  Volume: 92 Pages: 509-521
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25871150
[Journal Article] A novel gene regulator, pyrrole-imidazole polyamide targeting ABCA1 gene increases cholesterol efflux from macrophages and plasma HDL concentration2014
- Author(s)
  Tsunemi A, Ueno T, Fukuda N, Watanabe T, Tahira K, Haketa A, Hatanaka Y, Tanaka S, Matsumoto T, Matsumoto Y, Nagase H, Soma M
- Journal Title
  
  Journal of Molecular Medicine
  
  Volume: 92 Pages: 509-521
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25871150
[Journal Article] A novel gene regulator, pyrrole-imidazole polyamide targeting ABCA1 gene increases cholesterol efflux from macrophages and plasma HDL concentration2014
- Author(s)
  Tsunemi A, Ueno T, Fukuda N, Watanabe T, Tahira K, Haketa A, Hatanaka Y, Tanaka S, Matsumoto T, Matsumoto Y, Nagase H, Soma M
- Journal Title
  
  Journal of Molecular Medicine
  
  Volume: 92 Issue: 5 Pages: 509-521
- DOI
  10.1007/s00109-013-1118-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390190, KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-25134718, KAKENHI-PUBLICLY-26112517, KAKENHI-PROJECT-26290060
[Journal Article] RNA binding properties of novel gene silencing pyrrole-imidazole polyamides.2013
- Author(s)
  Iguchi A, Fukuda N, Takahashi T, Watanabe T, Matsuda H, Nagase H, Bando T, Sugiyama H, Shimizu K.
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 36 Pages: 1152-1158
- NAID
  130003361484
- Data Source
  KAKENHI-PROJECT-25871150
[Journal Article] RNA binding properties of novel gene silencing pyrrole-imidazole polyamides.2013
- Author(s)
  Iguchi A, Fukuda N, Takahashi T, Watanabe T, Matsuda H, Nagase H, Bando T, Sugiyama H, Shimizu K.
- Journal Title
  
  Biol Pharm Bull.
  
  Volume: 36 Pages: 1152-1158
- NAID
  130003361484
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300344
[Journal Article] RNA binding properties of novel gene silencing pyrrole-imidazole polyamides2013
- Author(s)
  Iguchi A, Fukuda N, Takahashi T, Watanabe T, Matsuda H, Nagase H, Bando T, Sugiyama H, Shimizu K
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 36(7) Pages: 1152-8
- NAID
  130003361484
- Data Source
  KAKENHI-PROJECT-23300344
[Journal Article] Transcriptional inhibition of hypertrophic scars by a gene silencer pyrrole-imidazole polyamide, targeting to the TGF-bl promoter2011
- Author(s)
  Washio H, Fukuda N, Matsuda H, Nagase H, Watanabe T, Matsumoto Y, Terui T.
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 10 Pages: 1038-1038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790301
[Journal Article] Transcriptional regulation of progressive renal disease by the gene silencing pyrrole-imidazole polyamide targeted to the TGF-b1 promoter.2011
- Author(s)
  Matsuda Y, Fukuda N, Ueno T, Katakawa M, Wang X, Watanabe T, et al
- Journal Title
  
  Kidney International
  
  Volume: 79(1) Pages: 46-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790301
[Journal Article] Transcriptional inhibition of hypertrophic scars by a gene silencer, pyrrole-imidazole polyamide, targeting the TGF-β1 promoter2011
- Author(s)
  Washio H, Fukuda N, Matsuda H, Nagase H, Watanabe T, et al
- Journal Title
  
  J Invest Dermatol
  
  Volume: 131(10) Pages: 1987-1995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790301
[Journal Article] Transcriptional in hibition of hypertrophicscars by a gene silencer pyrroleimidazole polyamide targeted to the TGF-b 1 promoter2011
- Author(s)
  Matsuda Y, Fukuda N, Ueno T, Katakawa M, Wang X, Watanabe T, Matsui S, Aoyama T, Saito K, Banda T, Matsumoto Y, Nagase H, Matsumoto K, Sugiyama H.
- Journal Title
  
  Kidney International
  
  Volume: 79(1) Pages: 46-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790301
[Journal Article] Development of a novel gene silencer pyrrole-imidazole polyamide targeting human connective tissue growth factor2011
- Author(s)
  Wan JX, Fukuda N, Ueno T, Watanabe T, Matsuda H, Saito K, et al
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 34(10) Pages: 1572-1577
- NAID
  130001086589
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790301
[Journal Article] Development of a Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human Connective Tissue Growth Factor2011
- Author(s)
  Wan JX, Fukuda N, Ueno T, Watanabe T, Matsuda H, Saito K, Nagase H, Matsumoto Y, Matsumoto K
- Journal Title
  
  BIOLOGICAL & PHARMACEUTICAL BULLETIN 34
  
  Volume: 10 Pages: 1572-1577
- NAID
  130001086589
- Data Source
  KAKENHI-PROJECT-23300344
[Journal Article] Development of a Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human Connective Tissue Growth Factor2011
- Author(s)
  Wan JX, Fukuda N, Ueno T, Watanabe T, Matsuda H, Saito K, Nagase H, Matsumoto Y, Matsumoto K
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 34 Issue: 10 Pages: 1572-1577
- DOI
  10.1248/bpb.34.1572
- NAID
  130001086589
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300344
[Journal Article] Inhibition of MMP-g transcription and suppression of tumor metastasis by pyrroleimidazole polyamide2010
- Author(s)
  Wang X, Nagase H, Watanabe T, Nobusue H, Suzuki T, Asami Y, Shinojima Y, Kawashima H, Takagi K, Mishra R, Igarashi J, Kimura M, Takayama T, Fukuda N, Sugiyama H.
- Journal Title
  
  Cancer Science
  
  Volume: 101(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790301
[Journal Article] Pretranscriptional regulation of regulation of Tgf-beta1 by PI polyamide prevents scarring and accelerates wound healing of cornea after exposure to alkali2010
- Author(s)
  Chen M, Matsuda H, Wang L, Watanabe T Kimura MT, Nagase H., et al
- Journal Title
  
  Molecular Therapy
  
  Volume: 18(3) Pages: 519-527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790301
[Journal Article] Inhibition of MMP-9 transcription and suppression of tumor metastasis by pyrrole-imidazole polyamide2010
- Author(s)
  Wang X, Nagase H, Watanabe T, Nobusue H, Suzuki T, et al
- Journal Title
  
  Cancer Science
  
  Volume: 101(3) Pages: 759-766
- NAID
  10026589912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790301
[Journal Article] Synthetic small molecules for epigenetic activation of pluripotent genes in mouse embryonic fibroblasts
- Author(s)
  Pandian GN, Shinohara K, Ohtsuki A, Nakano Y, Minoshima M, Bando T, Nagase H, Yamada Y, Watanabe A, Terada N, Sato S, Morinaga H and Sugiyama H
- Journal Title
  
  ChemBioChem
  
  Volume: 12(18) Pages: 2822-2
- Data Source
  KAKENHI-PROJECT-23300344
[Patent] 二重膜構造細胞内小器官DNA標的薬2019
- Inventor(s)
  永瀬浩喜渡部隆義　越川信子　安井七海
- Industrial Property Rights Holder
  千葉県
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-19K07408
[Patent] 二重膜構造細胞内小器官ＤＮＡ標的薬2019
- Inventor(s)
  永瀬浩喜　越川信子　渡部隆義　安井七海
- Industrial Property Rights Holder
  千葉県
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16K09978
[Patent] 新規アルキル化剤2016
- Inventor(s)
  永瀬浩喜、服部あすか、高取敦志、渡部隆義
- Industrial Property Rights Holder
  千葉県
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-184892
- Filing Date
  2016-09-21
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] F1174L 変異 ALK 遺伝子の選択的 DNA アルキル化は神経芽腫において抗腫瘍効果を示す2022
- Author(s)
  高取敦志、太田陽子、養田裕行、井上貴博、渡部隆義、永瀬浩喜
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07710
[Presentation] Synergistic effect of ATR inhibition and MYCN-targeted DNA damage in neuroblastoma2022
- Author(s)
  頼笑疑, 高取敦志, 養田裕行, 篠崎喜脩, 渡部隆義, 永瀬浩喜
- Organizer
  第81回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07245
[Presentation] ATR阻害とMYCNターゲティングにより、PARP阻害剤非感受性MYCN-amp神経芽腫細胞に高い効果を示した2022
- Author(s)
  頼笑疑, 高取敦志, 養田裕行, 篠崎喜脩, 渡部隆義, 永瀬浩喜
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K07245
[Presentation] ATR 阻害剤と神経芽腫において MYCN 標的 DNA 損傷と相乗効果を示す2022
- Author(s)
  頼笑疑、養田裕行、篠崎喜脩、渡部隆義、永瀬浩喜、高取敦志
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07710
[Presentation] Development of Novel Therapies Targeting the Amplified MYCN Gene in Neuroblastoma2022
- Author(s)
  頼　笑疑、養田裕行、篠崎喜脩、渡部隆義、永瀬浩喜、高取敦志
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] TPP 結合 DNA ジャイレース阻害剤による mtDNA 複製阻害を介したがん細胞の増殖阻害2022
- Author(s)
  喬いく銘、木田裕貴、渡部隆義、越川信子、竹永啓三
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07710
[Presentation] Site-selective DNA alkylation within the F1174L-muated ALK gene shows anti-tumor activity in neuroblastoma2022
- Author(s)
  高取敦志, 太田陽子, 養田裕行, 渡部隆義, 永瀬浩喜
- Organizer
  第81回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07245
[Presentation] 非小細胞肺癌を標的とした変異mtDNA標的PIP-TPPとBcl-xL阻害剤の併用療法の開発2021
- Author(s)
  山本清義、越川信子、木田裕貴、渡部隆義、Lin Jason、竹永啓三、永瀬浩喜
- Organizer
  先端モデル動物支援若手支援技術講習会
- Data Source
  KAKENHI-PROJECT-19K07408
[Presentation] 変異mtDNA標的PIP-TPPとBcl-xL阻害剤の併用による非小細胞肺癌A549腫瘍のSenotherapy2021
- Author(s)
  山本清義、越川信子、木田裕貴、渡部隆義、Lin Jason、竹永啓三、永瀬浩喜
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07408
[Presentation] Characterization of Cancer Genome-wide Binding of Pyrrole-Imidazole Polyamide-Vorinostat Conjugates by Machine Learning2021
- Author(s)
  J. Lin, I.Hosoya, S. Sakuma, Y, Kida, T, Watanabe, S. Yamamoto, A. Takatori, N. Koshikawa, H. Nagase
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07408
[Presentation] Targeting the mutant PIK3CA gene by DNA-alkylating pyrrole imidazole polyamide in cervical cancer2021
- Author(s)
  高取敦志、Sakthisri Krishnamurthy、養田裕行、井上貴博、平岡桐子、Jason Lin、渡部隆義、越川信子、永瀬浩喜
- Organizer
  第80回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] 神経芽腫のALK遺伝子変異を標的としたアルキル化ピロール・イミダゾールポリアミド化合物の抗腫瘍効果2021
- Author(s)
  太田陽子、養田裕行、井上貴博、渡部隆義、篠崎喜脩、永瀬浩喜、高取敦志
- Organizer
  第63回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] 神経芽腫のALK遺伝子異常を標的とした新規治療薬開発2020
- Author(s)
  高取敦志、太田陽子、養田裕行、井上貴博、渡部隆義、篠崎喜脩、永瀬浩喜
- Organizer
  第67回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] 神経芽腫のMYCN遺伝子特異的DNA傷害とPARP阻害剤の併用効果2020
- Author(s)
  高取敦志、養田裕行、渡部隆義、篠崎喜脩、永瀬浩喜
- Organizer
  第61回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] Investigation of antitumor effect of PIP-CBI derivatives containing amino group2020
- Author(s)
  渡部隆義
- Organizer
  第79回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07710
[Presentation] Development of a novel therapeutic strategy targeting amplified genomic region of oncogenes in solid cancers2020
- Author(s)
  高取敦志、養田裕行、渡部隆義、篠崎喜脩、永瀬浩喜、丸喜明、筆宝義隆
- Organizer
  第79回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] Evaluation of alkylating pyrrole-imidazole polyamides for novel therapy of neuroblastoma with ALK gene aberration2020
- Author(s)
  太田陽子、養田裕行、井上貴博、渡部隆義、篠崎喜脩、永瀬浩喜、高取敦志
- Organizer
  第79回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] Investigation of antitumor effect of PIP-CBI derivatives containing amino group2020
- Author(s)
  渡部隆義、高取敦志、篠崎喜脩、木田裕貴、越川信子、永瀬浩喜
- Organizer
  第79回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] 神経芽腫の増幅MYCN遺伝子を標的としたPIポリアミドDNAアルキル化剤の抗腫瘍活性と安全性2019
- Author(s)
  高取敦志、養田裕行、井上貴博、渡部隆義、越川信子、永瀬浩喜
- Organizer
  第32回モロシヌス研究会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] アルキル化ピロール・イミダゾールポリアミドを用いた膵癌における薬剤感受性関連遺伝子の探索2019
- Author(s)
  辻本彰子、養田裕行、Jason Lin 、松尾仁以奈、渡部隆義、篠崎喜脩、永瀬浩喜、高取敦志
- Organizer
  第78回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07259
[Presentation] ヒトテロメラーゼ逆転写酵素（hTERT）を標的としたアルキル化PDCによる治療戦略の構築2019
- Author(s)
  渡部隆義、高取敦史、養田裕行、越川信子、Lin Jason、篠崎喜脩、永瀬浩喜
- Organizer
  第28回日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-17K07259
[Presentation] mtDNA変異を標的にした修飾PIポリアミドによるROS産生亢進と細胞増殖の抑制2019
- Author(s)
  佐久間誠、辻航平、渡部隆義、越川信子、竹永啓三、永瀬浩喜
- Organizer
  第78回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07408
[Presentation] hTERT 遺伝子を標的とした PIP 化合物と抗癌活性の向上を指向した誘導体の開発2019
- Author(s)
  渡部隆義、高取敦志、養田裕行、越川信子、篠崎喜脩、永瀬浩喜
- Organizer
  第78回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07259
[Presentation] Novel therapeutic strategy for neuroblastoma by a combination of PARP inhibition and site-specific DNA damage within the amplified region of the MYCN gene2019
- Author(s)
  高取敦志、養田裕行、渡部隆義、篠崎喜脩、永瀬浩喜
- Organizer
  第78回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07767
[Presentation] 膵癌におけるアルキル化ピロール・イミダゾールポリアミドの薬理効果と感受性関連遺伝子の探索2018
- Author(s)
  辻本彰子、高取敦志、松尾仁以奈、K.Sakthisri、L.Jason、篠崎喜脩、渡部隆義、永瀬浩喜
- Organizer
  第27回日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-17K07259
[Presentation] PIポリアミド修飾化合物によるミトコンドリア標的遺伝子配列のコピース数減少の検討2018
- Author(s)
  安井七海・越川信子・渡部隆義・篠崎喜脩・高取敦志・Jason Lin・永瀬浩喜
- Organizer
  第27回癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-16K09978
[Presentation] TPPを用いたピロールイミダゾールポリアミドのミトコンドリアDNAへの導入とDNA複製への影響2018
- Author(s)
  安井七海・越川信子・渡部隆義・篠崎喜脩・高取敦志・リンジェイソン・竹永啓三・永瀬浩喜
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09978
[Presentation] 血中微量二本鎖核酸分子を標的とした PI ポリアミドを用いたがん遺伝子変異同定法の開発と臨床応用の検討2018
- Author(s)
  北川善康、奥村和弘、鈴木拓人、渡部隆義、早田浩明、傳田忠道、永瀬浩喜、山口武人
- Organizer
  日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-16K09333
[Presentation] 血中微量二本鎖核酸分子を標的とした PI ポリアミドを用いたがん遺伝子変異同定法の開発と臨床応用の検討2017
- Author(s)
  北川善康、奥村和弘、鈴木拓人、渡部隆義、早田浩明、傳田忠道、永瀬浩喜、山口武人
- Organizer
  第26回日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-16K09333
[Presentation] 膵腺管癌におけるKRAS 変異を標的にしたKR122017
- Author(s)
  松尾仁以奈、井上貴博、養田祐行、高取敦志、篠崎喜脩、渡部隆義、越川信子、ジェイソンリン、永瀬浩喜
- Organizer
  第76回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07259
[Presentation] Pyrrole-Imidazole polyamide conjugates targeting the cancer genome2016
- Author(s)
  Hiroki Nagase, Atsushi Takatori Takayoshi Watanabe, Nobuko Koshikawa, Kiriko Hiraoka, Takahiro Inoue, Hiroyuki Yoda, Jason Lin, Yoshinao Shinozaki, Krishnamurthy Sakthisri, Nina Matsuo, Asuka Hattori
- Organizer
  第８９回　日本生化学会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] ・Mutated cancer cell-specific cell death activity of alkylating Pyrrole-Imidazole polyamide conjugates targeting a variety of oncogenic driver gene mutations2016
- Author(s)
  Hiroki Nagase, Kiriko Hiraoka, Takahiro Inoue, Hiroyuki Yoda, Krishnamurthy Sakthisri, Jason Lin, Takayoshi Watanabe, Nobuko Koshikawa, Atsushi Takatori
- Organizer
  American Association　for Cancer Research Annual Meeting
- Place of Presentation
  ニューオリンズ　米国
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] ・MYCN遺伝子を標的としたPIポリアミドDNAアルキル化剤の抗腫瘍活性と安全性2016
- Author(s)
  高取敦志、養田裕行、井上貴博、渡部隆義、越川信子、若菜茂晴、永瀬浩喜
- Organizer
  第58回日本小児血液・がん学会学術集会
- Place of Presentation
  東京都品川
- Year and Date
  2016-12-15
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] Chem-seq:identifying genomic binding sites of a pyrrole-imidazole polyamide by nxt-generation sequencing2016
- Author(s)
  Lin Jason,Hiraoka Kiriko,Watanabe takayoshi,kuo Tony, Shinozaki Yoshinao,Takatori Atsushi,Koshikawa Nobuko,Otsuki Joe,Sugiyama Hiroshi,Horton Paul,Nagase Hiroki
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] ・Comprehensive genetic analysis for the anticancer activity of a novel alkylating targeting KRAS mutation2016
- Author(s)
  平岡桐子、Lin Jason、阿久澤夏樹、井上貴博、養田裕行、Krishnamurty Sakthise、渡部隆義、高取敦志、越川信子、尾崎俊文、永瀬浩喜
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] Tumor accumulation of a novel alkylating pyrrole-imidazole polyamide (KR12) targeting KRAS codon 12 mutations in murine xenograft models of human colon cancer2015
- Author(s)
  Takahiro Inoue, Kiriko Hiraoka, Yusei Suzuki, Hiroyuki Yoda, Takayoshi Watanabe, Atsushi Takatori, Nobuko Koshikawa, Toshinori Ozaki, Hiroki Nagase.
- Organizer
  AACR American Association for Cancer Research ANUAL MEETING 2015 　ミニシンポジウム　Exploiting the MAPK pathway in cancer
- Place of Presentation
  フィラデルフィア米国
- Year and Date
  2015-04-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] 神経芽腫に対するPIポリアミドDNAアルキル化剤複合体を用いた治療戦略2015
- Author(s)
  養田裕行,高取敦志,井上貴博,渡部隆義,越川信子,尾崎俊文,永瀬浩喜
- Organizer
  日本小児血液・がん学会
- Place of Presentation
  甲府
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] 変異型 KRAS 遺伝子を標的とした塩基配列特異的アルキル化剤の大腸癌細胞における抗腫瘍効果.2015
- Author(s)
  平岡桐子、井上貴博、養田裕行、Krishnamurty Sakthisri、高取敦志、篠原憲一、渡部隆義、越川信子、尾崎俊文、永瀬浩喜
- Organizer
  第24回癌病態治療研究会　ワークショップ
- Place of Presentation
  日光
- Year and Date
  2015-06-25
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] DNA配列認識小分子によるエピゲノム制御2015
- Author(s)
  篠原憲一, 依田夏美, 渡部隆義, 永瀬浩喜, 金田篤志
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市中央区）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26350977
[Presentation] KRAS遺伝子G12DおよびG12V 変異DNA配列を標的にした大腸がん治療薬の開発2015
- Author(s)
  永瀬浩喜.　平岡桐子、井上貴博、養田裕行、Krishnamurty Sakthisri、高取敦志、篠原憲一、渡部隆義、越川信子、尾崎俊文、
- Organizer
  第74回　日本癌学会　腫瘍別シンポジウム 1　大腸がんにおける標的分子と治療開発
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] PIポリアミド薬物複合体のMYCN遺伝子増幅難治性神経芽腫に対する革新的治療戦略への応用2015
- Author(s)
  養田裕行、高取敦志、井上貴博、渡部隆義、越川信子、尾崎俊文、永瀬浩喜
- Organizer
  第38回日本分子生物学会年会　第88回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] Anticancer activities of DNA-alkylating Pyrrole-Imidazole pylyamide conjugate targeting mutant KRAS2015
- Author(s)
  平岡桐子、井上貴博、養田裕行、Sakthisri Krishnamurthy、Jason Lin、渡部隆義、坂東俊和、杉山弘、尾崎敏文、永瀬浩喜
- Organizer
  第38回日本分子生物学会年会　第88回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] A novel alkylating pyrrole-imidazole polyamide, KR12, specifically recognizes mutant KRAS genes and potently induces cell death2015
- Author(s)
  Kiriko Hiraoka, Takahiro Inoue, Hiroyuki Yoda, Atsushi Takatori, Takayoshi Watanabe, Nobuko Koshikawa, Toshinori Ozaki, Hiroki Nagase.
- Organizer
  AACR American Association for Cancer Research ANUAL MEETING 2015 　ミニシンポジウム　Exploiting the MAPK pathway in cancer
- Place of Presentation
  フィラデルフィア米国
- Year and Date
  2015-04-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] A novel alkylating pyrrole-imidazole polyamide, KR12, specifically recognized mutant KRAS genes and potently induces cell death2015
- Author(s)
  K Hiraoka, T Inoue, H Yoda, A Takatori, T Watanabe, N Koshikawa, T Ozaki, H Nagase
- Organizer
  America Association for Cancer Research Annual Meeting 2015
- Place of Presentation
  アメリカ合衆国
- Year and Date
  2015-04-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461573
[Presentation] Inhibition of KRAS mutant colon cancer using a novel DNA-alkylating Pyrrole-Imidazole polyamide conjugate targeting KRAS Codon12 Mutant DNA2015
- Author(s)
  Hiroki Nagase, Kiriko Hiraoka, Takahiro Inoue, Takayoshi Watanabe, Ken-Ichi Shinohara, Nobuko Koshikawa, Ozaki Toshinori.
- Organizer
  3rd International Conference of Federation of Asian Clinical Oncology(FACO)
- Place of Presentation
  京都国際会議場
- Year and Date
  2015-10-29
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] KRASコドン12変異を標的とした分子標的アルキル化剤2014
- Author(s)
  永瀬浩喜、平岡桐子、井上隆博、渡部隆義
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] A novel alkylating pyrrole‐imidazole polyamide specifically targeting KRAS codon12 mutations preferentially suppresses the malignant phenotypes in colon cancer cells bearing G12D or G12V mutation.2014
- Author(s)
  Hiroki Nagase, Kiriko Hiraoka,Takahiro Inoue,Toshinori Ozaki,Takayoshi Watanabe,Ken-ichi Shinohara,Nobuko Koshokawa
- Organizer
  An AACR Special Conference on RAS ONCOGENES:FROM BIOLOGY TO THERAPY
- Place of Presentation
  オーランド　米国
- Data Source
  KAKENHI-PROJECT-25871150
[Presentation] Precision Medicineを目指したオンコジェニックドライバーを標的とした治療2014
- Author(s)
  永瀬浩喜、平岡桐子、井上隆博、渡部隆義、越川信子、尾崎俊文
- Organizer
  第23回癌病態治療研究会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-25871150
[Presentation] A novel alkylating pyrrole‐imidazole polyamide specifically targeting KRAS codon12 mutations preferentially suppresses the malignant phenotypes in colon cancer cells bearing G12D or G12V mutation2014
- Author(s)
  Nagase H, Hiraoka K, Inoue T, Ozaki T, Watanabe T, Shinohara K, Koshokawa N
- Organizer
  An AACR Special Conference on RAS ONCOGENES : FROM BIOLOGY TO THERAPY
- Place of Presentation
  オーランド米国
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] A novel alkylating pyrrole‐imidazole polyamide specifically targeting KRAS codon12 mutations preferentially suppresses the malignant phenotypes in colon cancer cells bearing G12D or G12V mutation.2014
- Author(s)
  Hiroki Nagase, Kiriko Hiraoka,Takahiro Inoue,Toshinori Ozaki,Takayoshi Watanabe,Ken-ichi Shinohara,Nobuko Koshokawa
- Organizer
  An AACR Special Conference on RAS ONCOGENES:FROM BIOLOGY TO THERAPY
- Place of Presentation
  オーランド　米国
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] KRAS G12D and G12V Specific Alkylating Agent (KR12) inhibits growth of colon cancer with those KRA mutations in vitro as well as in vivo2014
- Author(s)
  Hiroki Nagase, Kiriko Hiraoka, Takahiro Inoue, Takayoshi Watanabe, Ken-Ichi Shinohara, Nobuko Koshikawa, Ozaki Toshinori
- Organizer
  AACR American Association for Cancer Research ANUAL MEETING 2014
- Place of Presentation
  サンディエゴ米国
- Data Source
  KAKENHI-PROJECT-25871150
[Presentation] KRASコドン12変異を標的とした分子標的アルキル化剤2014
- Author(s)
  永瀬浩喜、平岡桐子、井上隆博、渡部隆義
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25871150
[Presentation] 新規Eボックス認識化合物によるMYC依存性腫瘍の増殖抑制2013
- Author(s)
  永瀬浩喜, 越川信子, 渡部隆義, 藤原恭子, MISHRA Rajeev
- Organizer
  第55回日本小児血液・がん学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] 変異型KRAS を標的とした配列特異的アルキル化剤による腫瘍細胞の増殖抑制2013
- Author(s)
  平岡桐子, 井上貴博, 養田裕行, 杉本博一, 篠原憲一, 渡部隆義, 越川信子, 板東俊和, 杉山弘, 尾崎俊文, 永瀬浩喜
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] 変異型KRASを標的とした塩基配列特異的アルキル化剤による腫瘍細胞の増殖抑制2013
- Author(s)
  平岡桐子, 井上貴博, 養田裕行, 杉本博一, 篠原憲一, 渡部隆義, 越川信子, 尾崎俊文, 永瀬浩喜, 板東俊和, 杉山弘
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25871150
[Presentation] 新規Eボックス認識化合物によるMYC依存性腫瘍の増殖抑制2013
- Author(s)
  永瀬浩喜, 越川信子, 渡部隆義, 藤原恭子, MISHRA Rajeev
- Organizer
  第55回日本小児血液・がん学会学術集会・第11回日本小児がん看護学会・第18回がんの子供を守る会公開シンポジウム
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-25871150
[Presentation] Automatic synthesis of efficient transcription inhibitors as anticancer agents designing sequence-specific DNA-banding molecules2013
- Author(s)
  Nagase H, Koshikawa N, Watanabe T
- Organizer
  AACR American Association for Cancer Research AAUAL MEETING 2013
- Place of Presentation
  ワシントン DC 米国
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] 変異型KRASを標的とした塩基配列特異的アルキル化剤によるマウス移植ヒト大腸癌の増殖抑制2013
- Author(s)
  井上貴博, 平岡桐子, 養田裕行, 杉本博一, 篠原憲一, 渡部隆義, 越川信子, 尾崎俊文, 永瀬浩喜, 坂東俊和, 杉山弘
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25871150
[Presentation] Automatic synthesis of efficient transcription inhibitors as anticancer agents designing sequence-specific DNA-banding molecules2013
- Author(s)
  Hiroki Nagase, Nobuko Koshikawa, Takayoshi Watanabe
- Organizer
  AACR American Association for Cancer Research AAUAL MEETING 2013
- Place of Presentation
  ワシントンDC 米国
- Data Source
  KAKENHI-PROJECT-25871150
[Presentation] 変異型KRASを標的とした塩基配列特異的アルキル化剤によるマウス移植ヒト大腸癌の増殖抑制2013
- Author(s)
  ・井上貴博, 平岡桐子, 養田裕行, 杉本博一, 篠原憲一, 渡部隆義, 越川信子, 尾崎俊文, 永瀬浩喜, 坂東俊和, 杉山弘
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] 標的ゲノム配列特異的なヒストンアセチル化の誘導2013
- Author(s)
  永瀬浩喜, 越川信子, 渡部隆義
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25871150
[Presentation] 変異型KRAS を標的とした塩基配列特異的アルキル化剤によるマウス移植ヒト大腸癌の増殖抑制2013
- Author(s)
  井上貴博, 平岡桐子, 養田裕行, 杉本博一, 篠原憲一, 渡部隆義, 越川信子, 板東俊和, 杉山弘, 尾崎俊文, 永瀬浩喜
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] KRASコドン12変異を標的とした分子標的アルキル化剤2013
- Author(s)
  永瀬浩喜, 平岡桐子, 井上隆博, 渡部隆義
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2013-06-26
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] Automatic synthesis of efficient transcription inhibitors as anticancer agents designing sequence-specific DNA-banding molecules.2013
- Author(s)
  Hiroki Nagase, Nobuko Koshikawa, Takayoshi Watanabe
- Organizer
  AACR American Association for Cancer Research AAUAL MEETING 2013
- Place of Presentation
  ワシントンDC アメリカ
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] 変異型KRASを標的とした塩基配列特異的アルキル化剤による腫瘍細胞の増殖抑制2013
- Author(s)
  ・平岡桐子, 井上貴博, 養田裕行, 杉本博一, 篠原憲一, 渡部隆義, 越川信子, 尾崎俊文, 永瀬浩喜, 板東俊和, 杉山弘
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] 標的ゲノム配列特異的なヒストンアセチル化の誘導2013
- Author(s)
  永瀬浩喜, 越川信子, 渡部隆義
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] 新規 E ボックス認識化合物による MYC 依存性腫瘍の増殖抑制2013
- Author(s)
  永瀬浩喜, 越川信子, 渡部隆義, 藤原恭子, Rajeev M
- Organizer
  第55回日本小児血液・がん学会学術集会・第11回日本小児がん看護学会・第18回がんの子供を守る会公開シンポジウム
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] MYCN TENSCRIPTION SILENCER BY USING SYNTHETIC PYRROLE-IMIDAZOLE POLYAMIDE MOLECULE IN NEUROBLASTOMA CELLS2012
- Author(s)
  Takahiro Watanabe, Hiroki Nagase
- Organizer
  7th INTERNATIONAL SOCIETY OF PEDIATRIC ONCOLOGY ASIA CONGRESS
- Place of Presentation
  Yogyokarta Indnesia
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] ゲノム配列特異的ヒストン修飾変更:がん化メカニズムの探索と治療への応用2012
- Author(s)
  永瀬浩喜、渡部隆義、越川信子、板東俊和、杉山弘
- Organizer
  第７１回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] 小分子化合物によるMEFでの多能性細胞誘導遺伝子のエピジェネティックな活性化2012
- Author(s)
  永瀬浩喜、渡部隆博、越川信子、井上貴博、平岡桐子、板東俊和、杉山弘
- Organizer
  第２６回モロシヌス研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] MYCN TENSCRIPTION SILENCER BY USING SYNTHETIC PYRROLE-IMIDAZOLE POL Y AMIDE MOLECULE IN NEUROBLASTOMA CELLS2012
- Author(s)
  Watanabe T, Nagase H
- Organizer
  7th INTERNA TIONAL SOCIETY OF PEDIA TRIC ONCOLOGY ASIA CONGRESS
- Place of Presentation
  Yogyokarta Indnesia
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] Target epigenetic regulation at a specific genomic region to induce stem cell like phenotype in neuroblastoma cells.2012
- Author(s)
  Nagase H , Watanabe T, Koshikawa N, Bando T, Sugiyama H.
- Organizer
  44th Congress of the International Society of Paediatric Oncology (SIOP)
- Place of Presentation
  London UK
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] DNA 結合化合物による疾患モデルマウスの表現型の変更2011
- Author(s)
  永瀬浩喜, 渡部隆博, 越川信子, 井上貴博, 石原優, 平岡桐子, 藤原恭子
- Organizer
  第25回モロシヌス研究会
- Place of Presentation
  十日町新潟
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] Target epigenetic regulation at a specific genomic region to induce stem cell like phenotype in nenroblastoma cells2011
- Author(s)
  Hiroki Nagase, Takayoshi Watanabe, Nobuko Koshikawa, Toshikazu Bando, Hiroshi Sugiyama
- Organizer
  The 43^<rd> SIOP meeting第43回国際小児がん学会
- Place of Presentation
  Auckland, New Zealand
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] 合成 DNA 結合化合物を用いた多能細胞・疾患モデルに対する表現型の変更2011
- Author(s)
  永瀬浩喜, 越川信子, 渡部隆義, 井上貴博, 石原優, 平岡桐子
- Organizer
  第87回発生工学・疾患モデル研究会
- Place of Presentation
  国立がんセンター
- Year and Date
  2011-08-19
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] ゲノム配列特異的なヒストン修飾阻害による細胞の運命変化2011
- Author(s)
  永瀬浩喜、渡部隆義、杉山弘
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] Molecular recognition of DNA : Application of Pyrrole-Imidazole (PI) polyamides for anti-inflammation and anti-cancer invasion2011
- Author(s)
  Hiroki Nagase, Nobuko Koshikawa, Takahiro Watanabe
- Organizer
  The 16 the Japan-Korea Cancer Research Workshop
- Place of Presentation
  札幌
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] Molecular Recognition of DNA : A tool for epigenetic DNA transcription regulation2011
- Author(s)
  Hiroki Nagase, Takayoshi Watanabe, Ken-ichi Shinohara, Hiroshi Sugiyama
- Organizer
  The 3^<rd> EMBO meeting
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PROJECT-23300344
[Presentation] ゲノム上のユニーク配列を認識するための新規PIポリアミドの開発2010
- Author(s)
  渡部隆義、永瀬浩喜
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22790301
[Presentation] ゲノム上のユニーク配列を認識するための新規PIポリアミドの開発2010
- Author(s)
  渡部隆義
- Organizer
  分子生物学会
- Place of Presentation
  神戸ポートアイランド2P-1315
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22790301
[Presentation] 変異型KRASを標的とした塩基配列特異的アルキル化剤によるヒト大腸癌細胞移植マウスの抗腫瘍効果
- Author(s)
  ・井上貴博、平岡桐子、養田裕行、丸喜明、杉本博一、篠原憲一、渡部隆義、高取敦志、越川信子、板東俊和、杉山弘、尾崎俊文、永瀬浩喜
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] がんドライバーミューテーション特異的アルキル化剤の開発
- Author(s)
  ・永瀬浩喜、平岡桐子、井上貴博、越川信子、渡部隆義
- Organizer
  第２8回　モロシヌス研究会
- Place of Presentation
  修善寺
- Year and Date
  2014-06-27 – 2014-06-28
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] A novel anti-cancer agent of DNA-alkylating Pyrrole-Imidazole polyamide conjugate targeting KRAS Codon 12 Mutant DNA
- Author(s)
  ・Hiroki nagase, Kiriko Hiraoka, Takahiro Inoue, Nobuko Koshikawa, Takayoshi Watanabe
- Organizer
  52st JSCO 2014 International Session Anti cancer agen
- Place of Presentation
  横浜
- Year and Date
  2014-08-28 – 2014-08-30
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] Efficient Gene Silencing by PI Polyamide with -crossed Formation Targeting MMP-9 Promoter
- Author(s)
  Takayoshi Watanabe, Nobuko Koshikawa, Toshinori Ozaki, Toshikazu Bando, Hiroshi Sugiyama, and Hiroki Nagase
- Organizer
  日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25871150
[Presentation] KRASコドン12変異を標的とした分子標的アルキル化剤
- Author(s)
  永瀬浩喜、平岡桐子、井上貴博、越川信子、渡部隆義
- Organizer
  第18回日本癌分子標的治療学会
- Place of Presentation
  仙台
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] Allele-specific knock-down of KRAS mutations in cancers by using a novel alkylating Pyrrole-Imidazole Polyamide (KR12)
- Author(s)
  ・Atsushi Takatori, AKiriko Hiraoka, Takahiro Inoue, Takayoshi Watanabe, Ken-Ichi Shinohara, Nobuko Koshikawa, Ozaki Toshinori. and Hiroki Nagase
- Organizer
  The 28th International Mammalian Genome Conference.
- Place of Presentation
  Bar Harbor, USA
- Year and Date
  2014-10-26 – 2014-10-29
- Data Source
  KAKENHI-PROJECT-26290060
[Presentation] Precision Medicineを目指したオンコジェニックドライバーを標的とした治療
- Author(s)
  ・永瀬浩喜、平岡桐子、井上隆博、渡部隆義、越川信子、尾崎俊文
- Organizer
  第23回癌病態治療研究会
- Place of Presentation
  岐阜
- Year and Date
  2014-06-12 – 2014-06-13
- Invited
- Data Source
  KAKENHI-PROJECT-26290060

1. NAGASE Hiroki (90322073)

# of Collaborated Projects: 8 results

# of Collaborated Products: 69 results
2. Koshikawa Nobuko (90260249)

# of Collaborated Projects: 6 results

# of Collaborated Products: 32 results
3. Takatori Atsushi (40455390)

# of Collaborated Projects: 4 results

# of Collaborated Products: 23 results
4. SUGIYAMA Hiroshi (50183843)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
5. 篠崎喜脩 (00766553)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. 藤原恭子 (40595708)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. Denda Tadamichi (90466053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. Shinohara Ken-ichi (70378561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. KANEDA Atsushi (10313024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. NEMOTO Tetsuhiro (80361450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SUZUKI Takayoshi (90372838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Shimizu Kimihiro (90375535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 板東俊和 (20345284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
14. 奥村和弘 (80584680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 竹永啓三 (80260256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. 石橋直也 (40649331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 西巻はるな (00834152)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 前林俊也 (20409006)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 前林亜紀 (90451369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 矢島俊樹 (20346852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 横堀武彦 (60420098)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 中澤世識 (60791978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 調憲 (70264025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 尾林海 (70726249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 丸喜明 (30742754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
26. YODA Natsumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
27. FUKUYO Masaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. TAKANE Kiyoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. KITA Kazuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. FUKUDA Noboru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. MATSUMOTO Taro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 浦野友彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 井上聰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 北川善康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 山本清義

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
36. LIN JASON

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
37. 伊川正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 篠原隆司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 筆宝義隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 齋藤都暁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Watanabe Takayoshi 渡部 隆義

WATANABE Takayoshi 渡部 隆義

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p300/CBP/PCAF・ HAT抑制法による難治性大腸癌の革新的治療戦略の構築Principal Investigator

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Exploring the potential of PIP-CBI derivatives with amino groups as anticancer agents for drug discoveryPrincipal Investigator

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Development of therapeutic strategy using molecules of targeting genomic mutation for pancreatic ductal carcinomaPrincipal Investigator

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Development of anticancer drug specifically targeting oncogenic driver mutationsPrincipal Investigator

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Watanabe Takayoshi 渡部隆義

WATANABE Takayoshi 渡部隆義