Iwasaki Yusaku 岩崎有作

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IWASAKI Yusaku 岩崎有作

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Researcher Number	60528420
Other IDs
Affiliation (Current)	2025: 京都府立大学, 生命環境科学研究科, 教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 京都府立大学, 生命環境科学研究科, 教授 2014 – 2017: 自治医科大学, 医学部, 講師 2011 – 2014: 自治医科大学, 医学部, 助教 2010: 自治医科大学, 医学部, ポスト・ドクター
Review Section/Research Field	Principal Investigator General physiology / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 59040:Nutrition science and health science-related Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / General physiology / Medium-sized Section 52:General internal medicine and related fields / Metabolomics
Keywords	Principal Investigator 求心性迷走神経 / GLP-1 / 摂食 / オキシトシン / グレリン / インスリン / nodose ganglion / エネルギー代謝 / 脂質 / 糖 … More / 熱産生 / 副腎 / 骨格筋 / アドレナリン / 体熱産生 / 糖尿病 / 肥満 / 過食 / 果糖 / 摂食亢進 / TRPA1 / 食欲不振 / 摂食抑制 / 糖代謝 / グルカゴン / 細胞内Ca / 延髄孤束核 / DNA microarray / oxytocin / peptide YY / pancreatic polypeptide / insulin / CART / 膵臓 / 逆行性トレーサー / インスリン受容体 / 細胞内Ca^<2+> / 迷走神経 / グルコース / ペプチドYY / 膵ポリペプチド / ホルモン / 迷走神経求心路 … More Except Principal Investigator 求心性迷走神経 / 摂食 / 弓状核 / 視床下部弓状核 / 不安 / 視床下部 / 糖代謝 / インスリン / 迷走神経 / POMC / オキシトシン / 自律神経 / アドレナリン / 副腎 / 交感神経 / 肥満・糖尿病 / 中枢神経 / バジプレッシン / 耐糖能 / 骨格筋 / 代謝 / 学習 / 希少糖アルロース / NPY神経 / POMC神経 / GLUT5 / Caイメージング / タニサイト / 摂食中枢 / アルロース / 希少糖 / 食材 / 食欲促進性求心性迷走神経 / がん / 抗ガン剤 / 認知 / Caチャネル / Neuropeptide Y / 認知機能 / イソアリイン / 人参養栄湯 / グレリン / neuropeptide Y / 抗がん剤 / 玉ねぎ / 漢方薬 / フレイル / 食欲不振 / 視交叉上核 / 細胞情報伝達 / インスリン感受性 / 高感受性 / PDK1 / PDK１ / オキシトシン神経 / 神経内分泌 / 室傍核 / GLP-1 / メタボリックシンドローム / 肥満症 / 抗肥満 / 概日リズム / 視床下部室傍核 / Nesfatin-1 Less

The investigation of the effect and underlying mechanism by which the intake of sugars and fats attenuates the beneficial effects after meals.Principal Investigator
- Principal Investigator
  
  岩崎有作
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Kyoto Prefectural University
Strategy for prevention and reduction of aspiration pneumonia and extension of healthy life expectancy by activation of dietary neuro-immune system
- Principal Investigator
  
  安部力
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Gifu University
The fructose paradox: analysis of the molecular mechanisms that inhibit the benefits of fructosePrincipal Investigator
- Principal Investigator
  
  Yusaku Iwasaki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Kyoto Prefectural University
Investigation of the role of <GLP-1 - autonomic nerves reflex - adrenal adrenaline> axis on diet-induced thermogenesisPrincipal Investigator
- Principal Investigator
  
  Iwasaki Yusaku
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kyoto Prefectural University
Establishing appetitive vagal afferent nerve for ameliorating anorexia, frailty, cancer and depression
- Principal Investigator
  
  Yada Toshihiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  株式会社関西メディカルネット(関西電力医学研究所)
Central and organ mechanisms for anti-obesity/diabetes effects of rare sugar allulose
- Principal Investigator
  
  YADA Toshihiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  株式会社関西メディカルネット(関西電力医学研究所)
Establishing orexigenic vagal afferent subclass and its physiological and pharmacological roles for treating anorexiaPrincipal Investigator
- Principal Investigator
  
  Iwasaki Yusaku
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kyoto Prefectural University
  Jichi Medical University
Molecular mechanism for highly sensitive response to peripheral hormones in hypothalamic neurons and homeostatic role
- Principal Investigator
  
  Yada TOSHIHIKO
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical University
Insulin action on vagal afferents and its regulation in feeding and metabolismsPrincipal Investigator
- Principal Investigator
  
  Yusaku Iwasaki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical University
GLP-1 and insulin synergize to activate vagal afferent nerves leading to central regulation of metabolism, feeding and blood pressure
- Principal Investigator
  
  YADA Toshihiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Vagal afferent-mediated coupling of peripheral factor sensing to brain transmission and feeding regulationPrincipal Investigator
- Principal Investigator
  
  IWASAKI YUSAKU
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical University
Regulation by nesfatin and oxytocin of feeding, metabolism and circadian rhythm, as a basis for treating life style-related diseases
- Principal Investigator
  
  YADA TOSHIHIKO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical University
Cellular and molecular mechanism of hormone sensing on vagal afferents and its linking to the feedingPrincipal Investigator
- Principal Investigator
  
  IWASAKI Yusaku
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical University

[Book] Advances in Medicine and Biology, Volume 1092016
- Author(s)
  Iwasaki, Y., Yada, T., Uneyama, H., and Kitamura, A.
- Total Pages
  29
- Publisher
  Nova Science Publishers
- Data Source
  KAKENHI-PROJECT-26460302
[Book] Nesfatin-1 の摂食抑制神経経路およびストレス, 循環, 生殖における役割. 日本薬理学雑誌2011
- Author(s)
  前島裕子, Sedbazar Udval, 岩崎有作, 高野英介, 矢田俊彦
- Publisher
  金芳堂日本薬理学会誌出版部
- Data Source
  KAKENHI-PROJECT-23390044
[Journal Article] Glucose‐dependent insulinotropic polypeptide counteracts diet‐induced obesity along with reduced feeding, elevated plasma leptin and activation of leptin‐responsive and proopiomelanocortin neurons in the arcuate nucleus2023
- Author(s)
  Han Wanxin、Wang Lei、Ohbayashi Kento、Takeuchi Masakazu、O'Farrell Libbey、Coskun Tamer、Rakhat Yermek、Yabe Daisuke、Iwasaki Yusaku、Seino Yutaka、Yada Toshihiko
- Journal Title
  
  Diabetes, Obesity and Metabolism
  
  Volume: 25 Issue: 6 Pages: 1534-1546
- DOI
  10.1111/dom.15001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19504, KAKENHI-PROJECT-19H04045, KAKENHI-PROJECT-23K28017
[Journal Article] Onion component, isoalliin, stimulates feeding and activates the arcuate nucleus neuropeptide Y, ghrelin- and Ninjin’yoeito-responsive neurons.2021
- Author(s)
  Wang L, Han W, Iwasaki Y, Yermek R, Sharp GW, Seino Y, Yada T.
- Journal Title
  
  Neuropeptides
  
  Volume: 89 Pages: 102180-102180
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22611
[Journal Article] Peripheral circadian rhythms in the liver and white adipose tissue of mice are attenuated by constant light and restored by time-restricted feeding2020
- Author(s)
  Yamamuro Daisuke、Takahashi Manabu、Nagashima Shuichi、Wakabayashi Tetsuji、Yamazaki Hisataka、Takei Akihito、Takei Shoko、Sakai Kent、Ebihara Ken、Iwasaki Yusaku、Yada Toshihiko、Ishibashi Shun
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 6 Pages: e0234439-e0234439
- DOI
  10.1371/journal.pone.0234439
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08892, KAKENHI-PROJECT-19K22611, KAKENHI-PROJECT-19H04045, KAKENHI-PROJECT-17K09865, KAKENHI-PROJECT-19H03712
[Journal Article] The liver-brain-gut neural arc maintains the Treg cell niche in the gut2020
- Author(s)
  Teratani T, Mikami Y, Nakamoto N, Suzuki T, Harada Y, Okabayashi K, Hagihara Y, Taniki N, Kohno K, Sibata S, Miyamoto K, Ishigame H, Chu Po-Sung, Sujino T, Suda W, Hattori M, Matsui M, Okada T, Okano H, Inoue M, Yada T, Kitagawa Y, Yoshimura A, Tanida M, Tsuda M, Iwasaki Y, Kanai T.
- Journal Title
  
  Nature
  
  Volume: 585 Issue: 7826 Pages: 591-596
- DOI
  10.1038/s41586-020-2425-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22611, KAKENHI-PROJECT-20K17062, KAKENHI-PROJECT-17H05082, KAKENHI-PROJECT-17H06110, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-19H05658, KAKENHI-PROJECT-20H00536, KAKENHI-PROJECT-19H04045, KAKENHI-PROJECT-20H03665, KAKENHI-PROJECT-20H03666, KAKENHI-PROJECT-20H04133, KAKENHI-PROJECT-20K20384, KAKENHI-PROJECT-19K22624, KAKENHI-PROJECT-18K14840, KAKENHI-PROJECT-18KK0246
[Journal Article] Relay of peripheral oxytocin to central oxytocin neurons via vagal afferents for regulating feeding.2019
- Author(s)
  Iwasaki Y, Kumari P, Wang L, Hidema S, Nishimori K, Yada T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 519(3) Issue: 3 Pages: 553-558
- DOI
  10.1016/j.bbrc.2019.09.039
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22611, KAKENHI-PROJECT-19H04045, KAKENHI-PROJECT-17K07745, KAKENHI-PROJECT-15H02442
[Journal Article] Short chain fatty acids suppress food intake by activating vagal afferent neurons.2018
- Author(s)
  Goswami, C., Iwasaki, Y.* and Yada, T.
- Journal Title
  
  J. Nutr. Biochem.
  
  Volume: 57 Pages: 130-135
- DOI
  10.1016/j.jnutbio.2018.03.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460302
[Journal Article] GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose2018
- Author(s)
  Iwasaki Yusaku、Sendo Mio、Dezaki Katsuya、Hira Tohru、Sato Takehiro、Nakata Masanori、Goswami Chayon、Aoki Ryohei、Arai Takeshi、Kumari Parmila、Hayakawa Masaki、Masuda Chiaki、Okada Takashi、Hara Hiroshi、Drucker Daniel J.、Yamada Yuichiro、Tokuda Masaaki、Yada Toshihiko
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 113-113
- DOI
  10.1038/s41467-017-02488-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09397, KAKENHI-PROJECT-15K09442, KAKENHI-PROJECT-26460302, KAKENHI-PROJECT-16K08497
[Journal Article] Glucagon-like peptide-1 and insulin synergistically activate vagal afferent neurons.2017
- Author(s)
  Iwasaki, Y., Goswami, C., and Yada, T.
- Journal Title
  
  Neuropeptide
  
  Volume: 65 Pages: 77-82
- DOI
  10.1016/j.npep.2017.05.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460302, KAKENHI-PROJECT-16K15182
[Journal Article] Ghrelin counteracts insulin-induced activation of vagal afferent neurons via growth hormone secretagogue receptor.2015
- Author(s)
  Iwasaki, Y., Dezaki, K., Kumari, P., Kakei, M., and Yada, T.
- Journal Title
  
  Neuropeptide
  
  Volume: 52 Pages: 55-60
- DOI
  10.1016/j.npep.2015.06.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460302, KAKENHI-PROJECT-26670453
[Journal Article] Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: a route for ameliorating hyperphagia and obesity.2015
- Author(s)
  Iwasaki, Y., Y. Maejima, S. Suyama, M. Yoshida, T. Arai, K. Katsurada, P. Kumari, H. Nakabayashi, M. Kakei, and T. Yada,
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol.
  
  Volume: 308 Issue: 5 Pages: R360-R369
- DOI
  10.1152/ajpregu.00344.2014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591340, KAKENHI-PROJECT-26460302, KAKENHI-PROJECT-26670453, KAKENHI-PROJECT-15K09396
[Journal Article] Glucagon directly interacts with vagal afferent nodose ganglion neurons to induce Ca(2+) signaling via glucagon receptors.2015
- Author(s)
  Ayush EA, Iwasaki Y, Iwamoto S, Nakabayashi H, Kakei M, Yada T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 456 Issue: 3 Pages: 727-732
- DOI
  10.1016/j.bbrc.2014.12.031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461377, KAKENHI-PROJECT-26460302, KAKENHI-PROJECT-26670453
[Journal Article] Endogenous GLP-1 acts on paraventricular nucleus to suppress feeding: projection from nucleus tractus solitarius and activation of corticotropin-releasing hormone, nesfatin-1 and oxytocin neurons.2014
- Author(s)
  Katsurada K, Maejima Y, Nakata M, et al.
- Journal Title
  
  iochem Biophys Res Commun.
  
  Volume: 451 Issue: 2 Pages: 276-281
- DOI
  10.1016/j.bbrc.2014.07.116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592277, KAKENHI-PROJECT-26670453
[Journal Article] Pancreatic polypeptide and peptide YY3-36 induce Ca2+ signaling in nodose ganglion neurons.2013
- Author(s)
  Iwasaki, Y.
- Journal Title
  
  Neuropeptides
  
  Volume: 47(1) Pages: 19-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790221
[Journal Article] Insulin activates vagal afferent neurons including those innervating pancreas via insulin cascade and Ca2+ influx: its dysfunction in IRS2-KO mice with hyperphagic obesity.2013
- Author(s)
  Yusaku Iwasaki
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 6 Pages: e67198-e67198
- DOI
  10.1371/journal.pone.0067198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591320, KAKENHI-PROJECT-24592277, KAKENHI-PROJECT-24790221
[Journal Article] Pancreatic polypeptide and peptide YY3-36 induce Ca^<2+> signaling in nodose ganglion neurons2013
- Author(s)
  Iwasaki Y, Kakei M, Nakabayashi H, Ayush EA, Hirano-Kodaira M, Maejima Y, Yada T
- Journal Title
  
  Neuropeptides
  
  Volume: 47(1) Issue: 1 Pages: 19-23
- DOI
  10.1016/j.npep.2012.07.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390044, KAKENHI-PROJECT-24659101, KAKENHI-PROJECT-24790221, KAKENHI-PUBLICLY-23115715
[Journal Article] Bupropion can close KATP channel and induce insulin secretion2013
- Author(s)
  Yang Y, Shimomura K, Sakuma K, Maejima Y, Iwasaki Y, Galvanovskis J, Dezaki K, Nakata M, Yada T
- Journal Title
  
  J Pediatr Endocrinol Metab
  
  Volume: 26(3-4) Issue: 3-4 Pages: 343-346
- DOI
  10.1515/jpem-2012-0295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390044, KAKENHI-PROJECT-23591320, KAKENHI-PROJECT-24591341, KAKENHI-PROJECT-24592277, KAKENHI-PROJECT-24659101, KAKENHI-PROJECT-24890218, KAKENHI-PUBLICLY-23115715, KAKENHI-PUBLICLY-23126523
[Journal Article] Vagal afferents sense meal-associated gastrointestinal and pancreatic hormones : mechanism and physiological role2012
- Author(s)
  Iwasaki, Y. and Yada, T
- Journal Title
  
  Neuropeptides
  
  Volume: 46(6) Issue: 6 Pages: 291-297
- DOI
  10.1016/j.npep.2012.08.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790221
[Journal Article] Vagal afferents sense meal-associated gastrointestinal and pancreatic hormones: mechanism and physiological role.2012
- Author(s)
  Iwasaki, Y.
- Journal Title
  
  Neuropeptides
  
  Volume: 46(6) Pages: 291-297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790221
[Journal Article] Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass2011
- Author(s)
  Maejima Y, Iwasaki Y, Yamahara Y, Kodaira M, Sedbazar U, Yada T
- Journal Title
  
  Aging (Albany NY)
  
  Volume: 3(12) Pages: 1169-1177
- URL
  http://www.impactaging.com/papers/v3/n12/full/100408.html
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390044
[Journal Article] Insulin suppresses ghrelin-induced calcium signaling in neuropeptide Y neurons of the hypothalamic arcuate nucleus2011
- Author(s)
  Maejima Y, Kohno D, Iwasaki Y, Yada T
- Journal Title
  
  Aging (Albany NY)
  
  Volume: 3(11) Pages: 1092-1097
- URL
  http://www.impactaging.com/papers/v3/n11/full/100400.html
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390044
[Patent] 食欲不振改善用組成物2018
- Inventor(s)
  岩崎有作、矢田俊彦
- Industrial Property Rights Holder
  学校法人自治医科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K08546
[Patent] GLP-1分泌促進剤2015
- Inventor(s)
  矢田俊彦、岩崎有作、原博、比良徹、岸本由香、南真知子
- Industrial Property Rights Holder
  自治医科大学、北海道大学、松谷化学工業株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-149634
- Filing Date
  2015-07-29
- Data Source
  KAKENHI-PROJECT-26670453
[Patent] 肥満・メタボリックシンドローム治療薬, 及びその動物の治療方法2011
- Inventor(s)
  矢田俊彦(届出・代表), 前島裕子, 岩崎有作
- Industrial Property Rights Holder
  自治医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2011-271652
- Filing Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-23390044
[Presentation] 腸ホルモンGLP-1の感覚神経・脳・副腎交感神経反射を介したアドレナリン分泌促進による体熱産生作用2022
- Author(s)
  武藤明日香、谷田守、安部力、矢田俊彦、岩崎有作
- Organizer
  第76回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-20H04128
[Presentation] 腸ホルモン GLP-1 の感覚神経・脳・副腎交感神経を介したアドレナリン分泌促進による体熱産生作用2022
- Author(s)
  武藤明日香、谷田守、安部力、矢田俊彦、岩崎有作
- Organizer
  第43回日本肥満学会・第40回日本肥満症治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20H04128
[Presentation] 腸ホルモンGLP-1の神経反射によるアドレナリン分泌促進を介した体熱産生作用2022
- Author(s)
  武藤明日香、谷田守、安部力、矢田俊彦、岩崎有作
- Organizer
  生理学研究所研究会2022 年度温度生理学研究会
- Data Source
  KAKENHI-PROJECT-20H04128
[Presentation] 食後に分泌される腸ホルモンGLP-1のアドレナリンβ受容体を介した体熱産生作用2021
- Author(s)
  武藤明日香、谷田守、矢田俊彦、岩崎有作
- Organizer
  第75回日本栄養・食糧学会
- Data Source
  KAKENHI-PROJECT-20H04128
[Presentation] 腸ホルモンGLP-1の自律神経とアドレナリン分泌を介した体熱産生作用2021
- Author(s)
  武藤明日香、谷田守、安部力、矢田俊彦、岩崎有作
- Organizer
  第60回日本栄養・食糧学会近畿支部大会
- Data Source
  KAKENHI-PROJECT-20H04128
[Presentation] 3種単糖：グルコース、フルクトース、アルロースのGLP-1分泌能と体熱産生作用の比較2020
- Author(s)
  坂本侑津希、武藤明日香、矢田俊彦、岩崎有作
- Organizer
  令和2年自然科学研究機構生理学研究所研究会温熱生理研究会
- Data Source
  KAKENHI-PROJECT-20H04128
[Presentation] Intestinal GLP-1 release by oral administration of rare sugar D-alluloseameliorates arrhythmic-overeating and obesity via vagal afferents.2019
- Author(s)
  Yusaku Iwasaki and Toshihiko Yada
- Organizer
  NIPS International Workshop “Sensing food/nutrient/environment toward integrative metabolic regulation
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04045
[Presentation] Intestinal GLP-1 release by oral administration of rare sugar D-alluloseameliorates arrhythmic-overeating and obesity via vagal afferents.2019
- Author(s)
  Yusaku Iwasaki and Toshihiko Yada
- Organizer
  NIPS International Workshop “Sensing food/nutrient/environment toward integrative metabolic regulation
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22611
[Presentation] GLP-1とインスリンは相乗的に求心性迷走神経を活性化させる2017
- Author(s)
  岩崎有作，矢田俊彦
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K15182
[Presentation] 短鎖脂肪酸のブタン酸は求心性迷走神経を介して摂食量を抑制する．2017
- Author(s)
  Goswami Chayon，岩崎有作，矢田俊彦
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  アクトシティ浜松(静岡県浜松市)
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-26670453
[Presentation] GLP-1とインスリンの協働作用による求心性迷走神経活性化：食後機能、治療効果の推定機序2017
- Author(s)
  岩崎有作，ごしゃみちゃよん，矢田俊彦
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-16K15182
[Presentation] 希少糖D-Allulose摂取はGLP-1分泌促進と求心性迷走神経の活性化を介して摂食を抑制し、耐糖能を向上させる．2017
- Author(s)
  岩崎有作，Goswami Chayon，仙度光麻，出崎克也，比良徹，原博，徳田雅明，矢田俊彦
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  アクトシティ浜松(静岡県浜松市)
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-26670453
[Presentation] Peripherally injected oxytocin activates vagal afferents to suppress food intake and ameliorates hyperphagic obesity in db/db mice.2016
- Author(s)
  Iwasaki, Y., Maejima, Y., Suyama, S., Yoshida, M., Kakei, M. and Yada, T.
- Organizer
  Society for Neuroscience
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2016-11-12
- Data Source
  KAKENHI-PROJECT-26460302
[Presentation] D-Allulose stimulates GLP-1 release and vagal afferents to correct feeding disorder, visceral obesity and hyperglycemia in obese mice.2016
- Author(s)
  Iwasaki Y, Kumari P, Hira T, Dezaki K, Goswami C, Hara H, Tokuda M, Yada T
- Organizer
  6th Symposium of International Society of Rare Sugars
- Place of Presentation
  Kagawa International Conference Hall (Takamatsu, Kagawa, Japan)
- Year and Date
  2016-11-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670453
[Presentation] TRPA1アゴニストによる摂食促進：摂食亢進性の新規求心性迷走神経サブグループの関与2016
- Author(s)
  岩崎有作，矢田俊彦
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  札幌
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-26670453
[Presentation] ゼロカロリー甘味料である希少糖D-AlluloseはGLP-1分泌と迷走神経活性化を介して糖尿病・過食・肥満を改善する．2016
- Author(s)
  岩崎有作，荒井健，Parmila Kumari，出崎克也，比良徹，原博，徳田雅明，矢田俊彦
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館、他(京都府京都市)
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26670453
[Presentation] 希少糖Allulose摂取によるGLP-1分泌は過食、摂食リズム障害、肥満を改善する．2016
- Author(s)
  岩崎有作，Parmila Kumari，比良徹，荒井健，出崎克也，原博，徳田雅明，矢田俊彦
- Organizer
  第37回日本肥満学会
- Place of Presentation
  東京ファッションタウンビル(東京都江東区)
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-26670453
[Presentation] Peripheral oxytocin administration activates vagal afferent nervesto suppress feeding, ameliorating hyperphagia and obesity in diabetic db/db mice.2015
- Author(s)
  Yada T, Iwasaki Y, Maejima Y, Suyama S, Yoshida M, Arai T, Katsurada K, Kumari P, Kakei M
- Organizer
  51st EASD Annual Meeting
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2015-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670453
[Presentation] GLP-1 and insulin synergistically activate vagal afferent nodose ganglion neurons.2015
- Author(s)
  Yada T, Iwasaki Y
- Organizer
  Incretin 2015. A Symposium Celebrating the 45th Anniversary of the Discovery of GIP
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2015-07-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670453
[Presentation] グルカゴンによる求心性迷走神経の活性化：中枢作用を仲介する伝達経路2015
- Author(s)
  岩崎有作，岩本禎彦，加計正文，矢田俊彦
- Organizer
  第36回日本肥満学会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26670453
[Presentation] Vagal afferent neurons sense pancreatic and plasma insulin: its impairment in hyperphasic obese mice2014
- Author(s)
  Iwasaki, Y., Shimomura, K., Kohno, D., Dezaki, K., Kakei, M., Nakata, M., and Yada, T.
- Organizer
  The 15th International Group on Insulin Secretion Symposia
- Place of Presentation
  フランス（ニース）
- Invited
- Data Source
  KAKENHI-PROJECT-24790221
[Presentation] Vagal afferent neurons sense pancreatic and plasma insulin : its impairment in hyperphasic obese mice2014
- Author(s)
  Iwasaki, Y
- Organizer
  The 15^<th> International Group on Insulin Secretion Symposia
- Place of Presentation
  Nice, France
- Data Source
  KAKENHI-PROJECT-24790221
[Presentation] Insulin directly activates vagal afferent neurons through insulin signaling pathway and voltage-dependent Ca^<2+> influx2013
- Author(s)
  Iwasaki, Y
- Organizer
  Neuro2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24790221
[Presentation] Insulin directly activates vagal afferent neurons through insulin signaling pathway and voltage-dependent Ca2+ influx2013
- Author(s)
  Iwasaki, Y., Shimomura, K., Ayush, E-A., Nakabayashi, H., Kubota, N., Kadowaki, T., Kakei, M., and Yada T.
- Organizer
  Neuro2013
- Place of Presentation
  京都府
- Data Source
  KAKENHI-PROJECT-24790221
[Presentation] 膵臓を支配する求心性迷走神経は膵臓から分泌されるインスリンを効率良く受容する2013
- Author(s)
  岩崎有作, 下村健寿, 河野大輔, 出崎克也, Enkh-Amar Ayush, 中林肇, 窪田直人, 門脇孝, 加計正文, 中田正範, 矢田俊彦
- Organizer
  第34回日本肥満学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390044
[Presentation] Peripheral oxytocin activates vagal afferent neurons and thereby decreases food intake2013
- Author(s)
  Iwasaki Y
- Organizer
  The 36^<th> Naito Conference
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-24790221
[Presentation] Peripheral oxytocin activates vagal afferent neurons and thereby decreases food intake2013
- Author(s)
  Yusaku Iwasaki, Yuko Maejima, Masahumi Kakei, Masashi Yoshida, Shiho Yamato, Hajime Nakabayashi, Toshihiko Yada,
- Organizer
  The 36th Naito Conference
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-24790221
[Presentation] オキシトシンの生理的摂食調節作用と末梢投与による抗肥満効果2012
- Author(s)
  前島裕子, 岩崎有作, Sedbazar Udval, 矢田俊彦
- Organizer
  第33回日本肥満学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23390044
[Presentation] Ghrelin attenuates insulin-induced activation of vagal afferent neurons of mice2012
- Author(s)
  Iwasaki Y
- Organizer
  Society for Neuroscience
- Place of Presentation
  New Orleans, USA(ポスター発表)
- Data Source
  KAKENHI-PROJECT-24790221
[Presentation] 求心性迷走神経へのインスリン作用はGLP-1により増強され、ghrelinにより抑制される2012
- Author(s)
  岩崎有作
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  長野県松本文化会館(長野県)
- Data Source
  KAKENHI-PROJECT-22790218
[Presentation] 膵ポリペプチドとペプチドYY_<3-36> の求心性迷走神経への直接作用2012
- Author(s)
  岩崎有作, 加計正文, 中林肇, 小平(平野)美里, 前島裕子, 矢田俊彦
- Organizer
  第33回日本肥満学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23390044
[Presentation] Ghrelin attenuates insulin-induced activation of vagal afferent neurons of mice.2012
- Author(s)
  Iwasaki, Y.
- Organizer
  Society for Neuroscience
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-24790221
[Presentation] インスリンの求心性迷走神経への直接作用とグレリン、GLP-1との相互作用2011
- Author(s)
  岩崎有作
- Organizer
  第32回日本肥満学会
- Place of Presentation
  淡路夢舞台国際会議場(兵庫県)
- Data Source
  KAKENHI-PROJECT-22790218
[Presentation] インスリンによるインスリン受容体カスケードを介した求心性迷走神経細胞Ca^<2+>シグナリング2011
- Author(s)
  岩崎有作
- Organizer
  第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会合同大会
- Place of Presentation
  横浜パシフィコ(神奈川県)
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-22790218
[Presentation] インスリンの求心性迷走神経への直接作用2011
- Author(s)
  岩崎有作
- Organizer
  自然科学研究機構生理学研究所研究会「中枢・末梢臓器連関による生体恒常性と仲介分子機構」
- Place of Presentation
  生理学研究所(愛知県)
- Year and Date
  2011-02-19
- Data Source
  KAKENHI-PROJECT-22790218
[Presentation] 求心性迷走神経へのインスリン作用のGLP-1による増強とグレリンによる抑制2011
- Author(s)
  岩崎有作
- Organizer
  第39回自律神経生理研究会
- Place of Presentation
  日本光電本社研修センター(東京都)
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-22790218
[Presentation] インスリンのNodose ganglionへの直接作用とシグナル伝達2010
- Author(s)
  岩崎有作
- Organizer
  第38回自律神経生理研究会
- Place of Presentation
  日本光電本社研修センター(東京都)
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-22790218
[Presentation] インスリンによる求心性迷走神経細胞活性化とシグナル伝達2010
- Author(s)
  岩崎有作
- Organizer
  第31回日本肥満学会
- Place of Presentation
  前橋プラザ元気21(群馬県)
- Data Source
  KAKENHI-PROJECT-22790218
[Presentation] 末梢Oxytocin は求心性迷走神経を活性化して摂食を抑制する．
- Author(s)
  岩崎有作，前島裕子，吉田昌史，荒井健，須山成朝，桂田健一，中林肇，加計正文，矢田俊彦
- Organizer
  第92回日本生理学会大会
- Place of Presentation
  神戸
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-26670453

1. YADA TOSHIHIKO (60166527)

# of Collaborated Projects: 5 results

# of Collaborated Products: 25 results
2. NAKATA Masanori (10305120)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. MAEJIMA Yuko (40438669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. TATSUYA Dezaki (90337329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. SHIGETOMO Suyama (80528414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 安部力 (10585235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 井上剛 (30821665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 永島秀一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 矢部大介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 加計正文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 岩本禎彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Iwasaki Yusaku 岩崎 有作

IWASAKI Yusaku 岩崎 有作

Research Projects

Research Products

Co-Researchers

The investigation of the effect and underlying mechanism by which the intake of sugars and fats attenuates the beneficial effects after meals.Principal Investigator

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Strategy for prevention and reduction of aspiration pneumonia and extension of healthy life expectancy by activation of dietary neuro-immune system

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The fructose paradox: analysis of the molecular mechanisms that inhibit the benefits of fructosePrincipal Investigator

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Investigation of the role of <GLP-1 - autonomic nerves reflex - adrenal adrenaline> axis on diet-induced thermogenesisPrincipal Investigator

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Establishing appetitive vagal afferent nerve for ameliorating anorexia, frailty, cancer and depression

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Central and organ mechanisms for anti-obesity/diabetes effects of rare sugar allulose

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Establishing orexigenic vagal afferent subclass and its physiological and pharmacological roles for treating anorexiaPrincipal Investigator

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Molecular mechanism for highly sensitive response to peripheral hormones in hypothalamic neurons and homeostatic role

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Insulin action on vagal afferents and its regulation in feeding and metabolismsPrincipal Investigator

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GLP-1 and insulin synergize to activate vagal afferent nerves leading to central regulation of metabolism, feeding and blood pressure

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Vagal afferent-mediated coupling of peripheral factor sensing to brain transmission and feeding regulationPrincipal Investigator

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Regulation by nesfatin and oxytocin of feeding, metabolism and circadian rhythm, as a basis for treating life style-related diseases

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Cellular and molecular mechanism of hormone sensing on vagal afferents and its linking to the feedingPrincipal Investigator

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Iwasaki Yusaku 岩崎有作

IWASAKI Yusaku 岩崎有作