Kojima Takashi 小島敬史

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Takashi Kojima 小島敬史

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Researcher Number	60528660
Other IDs
Affiliation (Current)	2025: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 聴覚・平衡覚研究部, 研究員 2025: 独立行政法人国立病院機構栃木医療センター(臨床研究部), NHO栃木医療センター, 耳鼻咽喉科医長
Affiliation (based on the past Project Information) *help	2023 – 2024: 独立行政法人国立病院機構栃木医療センター(臨床研究部), NHO栃木医療センター, 耳鼻咽喉科医長 2020 – 2024: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 聴覚・平衡覚研究部, 研究員 2016: 慶應義塾大学, 医学部(信濃町), 共同研究員 2015: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator 細胞毒性 / カリウムチャネル / KCNQ4 / 遺伝性難聴 / 先天性難聴 / 内耳有毛細胞 / 加齢性難聴 / 音響負荷 / 恒常性維持機能 / 蝸牛 / オートファジー / 内耳 … More Except Principal Investigator … More バリアント / 難聴 / 細胞死 / 遺伝性難聴 Less

the Contribution of Cell Death to the Pathophysiology of KCNQ4-Related Hereditary Hearing Loss and the Development of Therapeutic Agents
- Principal Investigator
  
  Koichiro Wasano
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Tokai University
  独立行政法人国立病院機構(東京医療センター臨床研究センター)
Establishing a protein functional analysis system using a KCNQ4 mutation-induced cell death modelPrincipal Investigator
- Principal Investigator
  
  Takashi Kojima
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Institute for Clinical Research, National Hospital Organization Tochigi Hospital
  独立行政法人国立病院機構(東京医療センター臨床研究センター)
Homeostasis with Inner Ear Specific Autophagy Deficit Model MicePrincipal Investigator
- Principal Investigator
  
  Kojima Takashi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Keio University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] The effect of aging and asymmetrical hearing on speech discrimination2024
- Author(s)
  Wasano Koichiro、Nakagawa Takashi、Kaga Kimitaka、Ogawa Kaoru
- Journal Title
  
  Communications Medicine
  
  Volume: 4 Issue: 1 Pages: 166-166
- DOI
  10.1038/s43856-024-00587-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09574, KAKENHI-PROJECT-24K02599
[Journal Article] Functional Studies of Deafness-Associated Pendrin and Prestin Variants2024
- Author(s)
  Takahashi Satoe、Kojima Takashi、Wasano Koichiro、Homma Kazuaki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 5 Pages: 2759-2759
- DOI
  10.3390/ijms25052759
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18330, KAKENHI-PROJECT-21K09574
[Journal Article] Prestin’s fast motor kinetics is essential for mammalian cochlear amplification2023
- Author(s)
  Takahashi Satoe、Zhou Yingjie、Kojima Takashi、Cheatham Mary Ann、Homma Kazuaki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 11
- DOI
  10.1073/pnas.2217891120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K18330
[Journal Article] Prestin's fast motor kinetics is essential for mammalian cochlear amplification2023
- Author(s)
  Satoe Takahashi, Yingjie Zhou, Takashi Kojima, Mary Ann Cheatham, Kazuaki Homma
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K18330
[Journal Article] Prevalence of Hearing Impairment by Age: 2nd to 10th Decades of Life2022
- Author(s)
  Wasano Koichiro、Nakagawa Takashi、Ogawa Kaoru
- Journal Title
  
  Biomedicines
  
  Volume: 10 Issue: 6 Pages: 1431-1431
- DOI
  10.3390/biomedicines10061431
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09574
[Journal Article] Cell death-inducing cytotoxicity in truncated KCNQ4 variants associated with DFNA2 hearing loss2021
- Author(s)
  Kojima Takashi、Wasano Koichiro、Takahashi Satoe、Homma Kazuaki
- Journal Title
  
  Disease Models & Mechanisms
  
  Volume: 14 Issue: 11
- DOI
  10.1242/dmm.049015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09574, KAKENHI-PROJECT-20K18330
[Presentation] ヒトとマウスのペンドリンにおけるミスセンスバリアントの機能的影響2021
- Author(s)
  小島敬史、和佐野浩一郎
- Organizer
  日本耳鼻咽喉科学会総会、学術講演会
- Data Source
  KAKENHI-PROJECT-20K18330
[Presentation] 若年発症型両側性難聴の原因遺伝子KCNQ4による難聴発生メカニズムに迫る2021
- Author(s)
  小島敬史、和佐野浩一郎
- Organizer
  日本聴覚医学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-20K18330
[Presentation] Functional Consequences of Missense Changes in Human and Mouse Pendrin2021
- Author(s)
  Kojima T, Wasano K, Takahashi S, Homma K
- Organizer
  Association for Research in Otolaryngology, midwinter meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18330
[Presentation] 若年発症型両側性難聴の原因遺伝子KCNQ4による難聴発生メカニズムに迫る2021
- Author(s)
  小島敬史、和佐野浩一郎
- Organizer
  第66回日本聴覚医学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09574
[Presentation] Functional Consequences of Missense Changes in Human and Mouse Pendrin2021
- Author(s)
  Kojima T, Takahashi S, Homma K
- Organizer
  Association for Research in Otolaryngology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18330
[Presentation] Cytotoxic KCNQ4 variants lacking the C-terminal cytosolic domain2020
- Author(s)
  Kojima T, Wasano K, Takahashi S, Homma K
- Organizer
  2020 Japan XR Science Forum
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18330
[Presentation] KCNQ4短縮型バリアントによる遺伝性難聴のin vitro病態解析と治療薬スクリーニング2020
- Author(s)
  小島敬史、和佐野浩一郎
- Organizer
  日本耳科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-20K18330

1. Koichiro Wasano (40528866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. 務台英樹 (60415891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KANZAKI Sho

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. FUJIOKA Masato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MITSUI Ayano

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kojima Takashi 小島 敬史

Takashi Kojima 小島 敬史

Research Projects

Research Products

Co-Researchers

the Contribution of Cell Death to the Pathophysiology of KCNQ4-Related Hereditary Hearing Loss and the Development of Therapeutic Agents

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishing a protein functional analysis system using a KCNQ4 mutation-induced cell death modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Homeostasis with Inner Ear Specific Autophagy Deficit Model MicePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The effect of aging and asymmetrical hearing on speech discrimination2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional Studies of Deafness-Associated Pendrin and Prestin Variants2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prestin’s fast motor kinetics is essential for mammalian cochlear amplification2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prestin's fast motor kinetics is essential for mammalian cochlear amplification2023

Author(s)

Journal Title

Data Source

[Journal Article] Prevalence of Hearing Impairment by Age: 2nd to 10th Decades of Life2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell death-inducing cytotoxicity in truncated KCNQ4 variants associated with DFNA2 hearing loss2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] ヒトとマウスのペンドリンにおけるミスセンスバリアントの機能的影響2021

Author(s)

Organizer

Data Source

[Presentation] 若年発症型両側性難聴の原因遺伝子KCNQ4による難聴発生メカニズムに迫る2021

Author(s)

Organizer

Data Source

[Presentation] Functional Consequences of Missense Changes in Human and Mouse Pendrin2021

Author(s)

Organizer

Data Source

[Presentation] 若年発症型両側性難聴の原因遺伝子KCNQ4による難聴発生メカニズムに迫る2021

Author(s)

Organizer

Data Source

[Presentation] Functional Consequences of Missense Changes in Human and Mouse Pendrin2021

Author(s)

Organizer

Data Source

[Presentation] Cytotoxic KCNQ4 variants lacking the C-terminal cytosolic domain2020

Author(s)

Organizer

Data Source

[Presentation] KCNQ4短縮型バリアントによる遺伝性難聴のin vitro病態解析と治療薬スクリーニング2020

Author(s)

Organizer

Data Source

Kojima Takashi 小島敬史

Takashi Kojima 小島敬史