Miyoshi Tomohiro 三好智博

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MIYOSHI Tomohiro 三好智博

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Researcher Number	60534550
Other IDs
Affiliation (Current)	2025: 大分大学, グローカル感染症研究センター, 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 大分大学, グローカル感染症研究センター, 講師 2017 – 2022: 松本歯科大学, 歯学部, 講師 2011 – 2016: 新潟大学, 研究推進機構, 助教 2014 – 2015: 新潟大学, 研究推進機構超域学術院, 助教 2012 – 2015: 新潟大学, 研究推進機構超域学術院, 助教 2012: 新潟大学, 研究推進機構超域学術院, 助教
Review Section/Research Field	Principal Investigator Basic Section 43010:Molecular biology-related / Molecular biology / Structural biochemistry Except Principal Investigator Basic Section 57020:Oral pathobiological science-related / Basic Section 57080:Social dentistry-related / Functional biochemistry / Structural biochemistry / Molecular biology
Keywords	Principal Investigator small RNA / Argonaute / 小分子RNA / DNAサイレンシング / ファージ / DNA silencing / 遺伝子発現制御 / non-coding RNA / RNAサイレンシング / RNA … More / 感染防御機構 / phage / DNA interference / 病原性 / プラスミド / DNA複製阻害 / シンバイオシス / サイレンシング / DNA / Rhodobacter sphaeroides / ウイルス / 小分子核酸 / X線結晶構造解析 / Dicer / プロセシング / miRNA / siRNA … More Except Principal Investigator 唾液蛋白質 / リボソーム蛋白質 / リボソーム / 生活習慣病 / ウイルス / ステロイド薬 / 唾液タンパク質 / ヒスタチン / ロイコトキシン / ワクチン / LFA-1 / LtxA / A. actinomycetemcomitans / 侵襲性歯周炎 / 抗体 / 蛋白質 / 免役化学 / 抗原性 / 抗P抗体 / 自己免疫 / 自己抗体 / 生化学 / X線結晶構造解析 / 翻訳 / アミノアシルtRNA合成酵素 / 触手様タンパク質 / 翻訳サイクル / ストーク / IF5B / EF-2 / EF-1α / 遺伝情報翻訳 / リボソームタンパク質 / リボソームストーク / 翻訳因子 Less

Regulatory mechanisms of glucose metabolism by salivary protein for prevention and improvement of lifestyle-related disease
- Principal Investigator
  
  今村泰弘
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  Matsumoto Dental University
A novel gene expression control system based on the prokaryotic ArgonautePrincipal Investigator
- Principal Investigator
  
  三好智博
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Oita University
Elucidation of the mechanism of salivary protein for reducing adverse effects of steroids and suppressing virus-induced inflammation
- Principal Investigator
  
  IMAMURA Yasuhiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Matsumoto Dental University
Association between acquisition of virulence factors and Argonaute protein in bacteriaPrincipal Investigator
- Principal Investigator
  
  Miyoshi Tomohiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Matsumoto Dental University
Elucidation of the molecular basis of leukotoxin-receptor interactions and development of a novel periodontitis vaccine.
- Principal Investigator
  
  Yoshida Akihiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Matsumoto Dental University
Research for the mechanism of DNA silencing using small RNA as a guide strandPrincipal Investigator
- Principal Investigator
  
  Miyoshi Tomohiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Matsumoto Dental University
  Niigata University
Elucidation of the structural basis for the interaction of the ribosomal stalk protein with aminoacyl-tRNA synthetase
- Principal Investigator
  
  Kosuke Ito
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Niigata University
A new method for producing site-specific anti-protein antibodies at will
- Principal Investigator
  
  Uchiumi Toshio
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Niigata University
Structural basis for small RNA functional mechanism in eukaryotesPrincipal Investigator
- Principal Investigator
  
  Miyoshi Tomohiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Niigata University
Ribosomal stalk complex driving translation cycle: molecular basis for high-speed and high-efficiency
- Principal Investigator
  
  UCHIUMI Toshio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  Niigata University
Analysis of maturation process of endo -siRNA precursorPrincipal Investigator
- Principal Investigator
  
  MIYOSHI Tomohiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Niigata University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] The natural bicyclic hexapeptide RA-VII is a novel inhibitor of the eukaryotic translocase eEF2.2022
- Author(s)
  Miyoshi T, Nomura T, Takeya K, Uchiumi T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 615 Pages: 88-93
- DOI
  10.1016/j.bbrc.2022.05.035
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06093, KAKENHI-PROJECT-20K05835
[Journal Article] Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis.2021
- Author(s)
  Miyoshi T, Oge S, Nakata S, Ueno Y, Ukita H, Kousaka R, Miura Y, Yoshinari N, Yoshida A.
- Journal Title
  
  Scientific reports
  
  Volume: 11(1) Issue: 8 Pages: 11742-11742
- DOI
  10.1111/pin.13110
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06494, KAKENHI-PROJECT-21H02931
[Journal Article] Structural insights into the switching off of the interaction between the archaeal ribosomal stalk and aEF1A by nucleotide exchange factor aEF1B.2021
- Author(s)
  Suzuki,T., Ito, K., Miyoshi, T., Murakami, R., Uchiumi, T.
- Journal Title
  
  J. Mol. Biol.
  
  Volume: - Issue: 15 Pages: 167046-167046
- DOI
  10.1016/j.jmb.2021.167046
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03155, KAKENHI-PROJECT-19K06494
[Journal Article] Structural insights into the switching off of the interaction between the archaeal ribosomal stalk and aEF1A by nucleotide exchange factor aEF1B2021
- Author(s)
  Takahiro Suzuki, Kosuke Ito, Tomohiro Miyoshi, Ryo Murakami, and Toshio Uchiumi
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06494
[Journal Article] Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis.2021
- Author(s)
  Miyoshi T, Oge S, Nakata S, Ueno Y, Ukita H, Kousaka R, Miura Y, Yoshinari N, Yoshida A.
- Journal Title
  
  Scientific Reports.
  
  Volume: 11 Issue: 1 Pages: 11742-11742
- DOI
  10.1038/s41598-021-91267-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02974
[Journal Article] Aggregatibacter actinomycetemcomitans induces detachment and death of human gingival epithelial cells and fibroblasts via elastase release following leukotoxin‐dependent neutrophil lysis2019
- Author(s)
  Hiyoshi Takumi、Domon Hisanori、Maekawa Tomoki、Nagai Kosuke、Tamura Hikaru、Takahashi Naoki、Yonezawa Daisuke、Miyoshi Tomohiro、Yoshida Akihiro、Tabeta Koichi、Terao Yutaka
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 63 Issue: 3-4 Pages: 100-110
- DOI
  10.1111/1348-0421.12672
- NAID
  40021899825
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17366, KAKENHI-PROJECT-17KK0165, KAKENHI-PROJECT-16H06272, KAKENHI-PROJECT-16K11439, KAKENHI-PROJECT-17K19747, KAKENHI-PROJECT-19K06494, KAKENHI-PROJECT-19K10126, KAKENHI-PROJECT-18KK0434, KAKENHI-PROJECT-18H02974
[Journal Article] The ribosomal stalk protein is crucial for the action of the conserved ATPase ABCE12018
- Author(s)
  Imai, H., Abe, T., Miyoshi, T., Nishikawa, S., Ito, K., and Uchiumi, T.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 46 Issue: 15 Pages: 7820-7830
- DOI
  10.1093/nar/gky619
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04741, KAKENHI-PROJECT-16J01001, KAKENHI-PROJECT-16K07246
[Journal Article] Nucleic Acid-Binding Assay of Argonaute Protein Using Fluorescence Polarization.2018
- Author(s)
  Miyoshi T.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 1680 Pages: 123-129
- DOI
  10.1007/978-1-4939-7339-2_8
- ISBN
  9781493973385, 9781493973392
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07246
[Journal Article] The interaction between the ribosomal stalk proteins and translation initiation factor 5B promotes translation initiation2018
- Author(s)
  Murakami, R., Singh, C.R., Morris, J., Tang, L., Harmon, I., Azuma, T., Miyoshi, T., Ito, K., Asano, K., and Uchiumi T.
- Journal Title
  
  Mol. Cell Biol.
  
  Volume: 38 Issue: 16
- DOI
  10.1128/mcb.00067-18
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04741, KAKENHI-PROJECT-16K07246
[Journal Article] Binding of translation elongation factors to individual copies of the archaeal ribosomal stalk protein aP1 assembled onto aP0.2017
- Author(s)
  Honda, T., Imai, H., Suzuki, T., Miyoshi, T, Ito K, Uchiumi T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 483 Issue: 1 Pages: 153-158
- DOI
  10.1016/j.bbrc.2016.12.175
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242075, KAKENHI-PROJECT-16J01001, KAKENHI-PROJECT-16K07246, KAKENHI-PROJECT-15K14472, KAKENHI-PROJECT-16H04741, KAKENHI-PROJECT-15K06964
[Journal Article] Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute.2016
- Author(s)
  Miyoshi, T., Ito, K., Murakami, R., Uchiumi T.
- Journal Title
  
  Nature Commun.
  
  Volume: 7 Issue: 1 Pages: 11846-11846
- DOI
  10.1038/ncomms11846
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242075, KAKENHI-PROJECT-16H04741, KAKENHI-PROJECT-16K07246
[Journal Article] Crystal structure of translation initiation factor 5B from the crenarchaeon Aeropyrum pernix.2016
- Author(s)
  Murakami R, Miyoshi T, Uchiumi T, Ito K.
- Journal Title
  
  Proteins
  
  Volume: in press Issue: 5 Pages: 712-717
- DOI
  10.1002/prot.25009
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26242075, KAKENHI-PROJECT-15J04972, KAKENHI-PROJECT-25840019, KAKENHI-PROJECT-16H04741, KAKENHI-PROJECT-16K07246
[Journal Article] Functional role of the C-terminal tail of the archaeal ribosomal stalk in recruitment of two elongation factors to the sarcin/ricin loop of 23S rRNA.2015
- Author(s)
  Imai, H, Miyoshi, T, Murakami, R, Ito, K, Ishino, Y, and Uchiumi, T.
- Journal Title
  
  Genes. Cells
  
  Volume: 20 Issue: 7 Pages: 613-624
- DOI
  10.1111/gtc.12256
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242075, KAKENHI-PROJECT-25840019, KAKENHI-PROJECT-15K14472
[Journal Article] Molecular insights into the interaction of the ribosomal stalk protein with elongation factor 1α.2014
- Author(s)
  Ito, K., Honda, T., Suzuki, T., Miyoshi, T., Murakami, R., Yao, M., and Uchiumi T.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 42 Issue: 22 Pages: 14042-14052
- DOI
  10.1093/nar/gku1248
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24370073, KAKENHI-PROJECT-24770093, KAKENHI-PROJECT-26242075
[Journal Article] Characterization of putative toxin-antitoxin systems in Vibrio parahaemolyticus2014
- Author(s)
  Hino, M., Zhang, J., Takagi, H., Miyoshi, T., Uchiumi, T., Nakashima, T., Kakuta, Y., and Kimura, M.
- Journal Title
  
  J Appl Microbiol
  
  Volume: publised on line Issue: 1 Pages: 185-195
- DOI
  10.1111/jam.12513
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24370073
[Journal Article] Solution structure of human P1-P2 heterodimer provides insights into the role of eukaryotic stalk in recruiting the ribosome-inactivating protein trichosanthin to the ribosome2013
- Author(s)
  Lee, K.M., Yusa, K., Chu, L.O., Yu, C.W., Oono, M., Miyoshi, T., Ito, K., Shaw, P.C., Wong, K.B., and Uchiumi, T
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 41 Issue: 18 Pages: 8776-8787
- DOI
  10.1093/nar/gkt636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657087, KAKENHI-PROJECT-24370073, KAKENHI-PROJECT-24770093, KAKENHI-PROJECT-25840019
[Journal Article] Roles of R2D2, a cytoplasmic D2 body component, in the endogenous siRNA pathway in Drosophila.2013
- Author(s)
  Nishida, KM.
- Journal Title
  
  Molecular Cell
  
  Volume: 49 Issue: 4 Pages: 680-691
- DOI
  10.1016/j.molcel.2012.12.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20221008, KAKENHI-PROJECT-23770210, KAKENHI-PROJECT-25221101
[Journal Article] Analysis of chimeric ribosomal stalk complexes from eukaryotic and bacterial sources: structural features responsible for specificity of translation factors2012
- Author(s)
  Mochizuki, M. 他
- Journal Title
  
  Genes to Cells
  
  Volume: 17 Issue: 4 Pages: 273-284
- DOI
  10.1111/j.1365-2443.2012.01586.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657087, KAKENHI-PROJECT-23770210
[Presentation] Identification of novel Helicobacter pylori virulence factors that regulates macrophage phagocytosis.2023
- Author(s)
  Naomi Aini, Weichen Gong, Kana Nishida, Tomohiro Miyoshi, Hitomi Mimuro
- Organizer
  九州微生物フォーラム2023
- Data Source
  KAKENHI-PROJECT-22K06093
[Presentation] Bactericidal effect of ozone ultrafine bubble water against oral bacteria2023
- Author(s)
  Fumio Takizawa, Hisanori Domon, Tomoki Maekawa, Takumi Hiyoshi, Hikaru Tamura, Tomohiro Miyoshi, Koichi Tabeta, Hiroaki Yoshida, Yutaka Terao
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-22K06093
[Presentation] Antimicrobial activity of substances produced by Serratia marcescens2022
- Author(s)
  Tomohiro Miyoshi, Chisato Ohori Yu Muto, Atsushi Ishihara, Kumiko Osaki-Oka, Hitomi Mimuro
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-22K06093
[Presentation] Serratia marcescensによる病原性細菌の生育抑制作用2022
- Author(s)
  三好智博、大堀千郷、武藤悠、石原亨、大崎久美子、吉田明弘
- Organizer
  第95回　日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18H02974
[Presentation] The growth inhibitory effect of pathogenic bacteria by Serratia marcescens2022
- Author(s)
  Tomohiro Miyoshi, Chisato Ohori, Yu Muto, Atsushi Ishihara, Kumiko Osaki-Oka, Akihiro Yoshida
- Organizer
  第95回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K06494
[Presentation] 歯周病原菌と競合する微生物：その探索と発見2021
- Author(s)
  大堀千郷、三好智博、吉田明弘
- Organizer
  第91回　松本歯科大学学会
- Data Source
  KAKENHI-PROJECT-18H02974
[Presentation] 歯周病原菌と競合する微生物-その探索と発見2021
- Author(s)
  大堀千郷, 三好智博, 吉田明弘
- Organizer
  第91回松本歯科大学学会
- Data Source
  KAKENHI-PROJECT-19K06494
[Presentation] リボソームストークタンパク質の構造・機能研究2020
- Author(s)
  伊東孝祐、丸山圭　今井大達　三好智博　内海利男
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K06494
[Presentation] Porphyromonas gingivalisの生育を特異的に阻害するGemella haemolysans2020
- Author(s)
  三好智博、吉成伸夫、吉田明弘
- Organizer
  第62回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19K06494
[Presentation] Gemella haemolysans specifically inhibits the growth of Porphyromonas gingivalis2020
- Author(s)
  Tomohiro Miyoshi, Nobuo Yoshinari and Akihiro Yoshida
- Organizer
  International Association for Dental Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06494
[Presentation] Hemolytic Gemella is Associated with Suppression of Periodontal Disease2019
- Author(s)
  Tomohiro Miyoshi, Satoshi Nakata, Shogo Oge, Yuji Ueno, Hidehiko Ukita, Reiko Kousaka, Nobuo Yoshinari, Akihiro Yoshida
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K06494
[Presentation] Hemolytic Gemella is Associated with Suppression of Periodontal Disease2019
- Author(s)
  Tomohiro Miyoshi, Satoshi Nakata, Shogo Oge, Yuji Ueno, Hidehiko Ukita, Reiko Kousaka, Nobuo Yoshinari, Akihiro Yoshida
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-18H02974
[Presentation] 口腔内における溶血性Gemellaと歯周病細菌P. gingivalisの関連性2019
- Author(s)
  三好智博、吉成伸夫、吉田明弘
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18H02974
[Presentation] Gemellaの口腔内における役割2019
- Author(s)
  三好智博、中田智是、大毛将吾、植野裕司、浮田英彦、高坂怜子、吉成伸夫、吉田明弘
- Organizer
  第51回レンサ球菌研究会
- Data Source
  KAKENHI-PROJECT-18H02974
[Presentation] 溶血性Gemellaが歯周病細菌Porphyromonas gingivalisに与える影響2019
- Author(s)
  三浦佑樹、中田智是、大毛翔吾、植野裕司、浮田英彦、高坂怜子、町野惇、三好智博、吉成伸夫、吉田明弘
- Organizer
  第102回日本細菌学会関東支部総会
- Data Source
  KAKENHI-PROJECT-18H02974
[Presentation] Gemellaの口腔内における役割2019
- Author(s)
  三好智博、中田智是、大毛将吾、植野裕司、浮田英彦、高坂怜子、吉成伸夫、吉田明弘
- Organizer
  第51回レンサ球菌研究会
- Data Source
  KAKENHI-PROJECT-19K06494
[Presentation] 溶血性細菌Gemellaの特性と歯周疾患との関連性2019
- Author(s)
  三浦佑樹、中田智是、大毛翔吾、植野裕司、浮田英彦、高坂怜子、町野惇、三好智博、吉成伸夫、吉田明弘
- Organizer
  第88回松本歯科大学学会
- Data Source
  KAKENHI-PROJECT-18H02974
[Presentation] 口腔内における溶血性Gemellaと歯周病細菌P. gingivalisの関連性2019
- Author(s)
  三好智博、吉成伸夫、吉田明弘
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19K06494
[Presentation] バクテリアの新たな自己防衛システム2018
- Author(s)
  三好智博
- Organizer
  第71回日本細菌学会関西支部総会
- Invited
- Data Source
  KAKENHI-PROJECT-16K07246
[Presentation] 翻訳リサイクル因子ABCE1-リボソームストーク間相互作用とその役割2017
- Author(s)
  今井大達, 阿部高也, 三好智博, 伊東孝祐, 内海利男
- Organizer
  第40回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-15K06964
[Presentation] 細菌で見つかった「RNAをガイド鎖とするDNAサイレンシング機構」の構造解析2017
- Author(s)
  三好智博
- Organizer
  岩手医科大学　構造生物薬学セミナー
- Data Source
  KAKENHI-PROJECT-16K07246
[Presentation] リボソームタンパク質aP1による翻訳ATPase因子の認識機構2017
- Author(s)
  今井大達、阿部高也、三好智博、伊東孝祐、内海利男
- Organizer
  第19回日本RNA学会
- Data Source
  KAKENHI-PROJECT-16K07246
[Presentation] 細菌ArgonauteのRNA-guided DNA interference2017
- Author(s)
  三好智博
- Organizer
  第11回細菌学若手コロッセウム
- Data Source
  KAKENHI-PROJECT-16K07246
[Presentation] 微生物におけるArgonauteの新機能2017
- Author(s)
  三好智博
- Organizer
  第5回五大学微生物研究会
- Data Source
  KAKENHI-PROJECT-16K07246
[Presentation] Argonauteタンパク質の新規構造基盤の解明2017
- Author(s)
  三好智博
- Organizer
  第1回オーラルサイエンス研究会
- Data Source
  KAKENHI-PROJECT-16K07246
[Presentation] 翻訳リサイクル因子ABCE1-リボソームストーク間相互作用とその役割2017
- Author(s)
  今井大達、阿部高也、三好智博、伊東孝祐、内海利男
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K07246
[Presentation] Archaeal ribosomal stalk protein aP1 directly binds to the ribosome-recycling factor aABCE1, and promotes ribosome-dependent ATP hydrolysis2017
- Author(s)
  Imai H, Abe T, Miyoshi T, Ito K and Uchiumi T
- Organizer
  EMBL Meeting
- Data Source
  KAKENHI-PROJECT-16K07246
[Presentation] Archaeal ribosomal stalk protein aP1 directly binds to the ribosome recycling factor aABCE1 and promotes ribosome-dependent ATP hydrolysis2017
- Author(s)
  Imai, H., Abe, T., Miyoshi, T., Ito, K., and Uchiumi, T.
- Organizer
  EMBL2017 Protein Synthesis and Translational Control
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06964
[Presentation] 光合成細菌で明らかとなったDNAサイレンシング機構2017
- Author(s)
  三好智博
- Organizer
  第2回光合成細菌ワークショップ
- Data Source
  KAKENHI-PROJECT-16K07246
[Presentation] リボソームストークC末端部位と翻訳因子間の結合多様性2016
- Author(s)
  丸山圭, 今井大達, 三好智博, 伊東孝祐, 内海利男
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K14472
[Presentation] 翻訳リサイクル反応におけるリボソームストークタンパク質P1の機能解析2016
- Author(s)
  今井大達, 阿部高也, 三好智博, 伊東孝祐, 内海利男
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K14472
[Presentation] 環状ペプチドRA-VIIはEF－2・GTP複合体構造を固定化する2016
- Author(s)
  三好智博、片貝勇人、下出朗誠、竹谷孝一、八森章、内海利男
- Organizer
  第4回 Ribosome Meeting
- Place of Presentation
  大阪医科大学
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16K07246
[Presentation] 翻訳反応の各ステージで機能するリボソームストーク・翻訳因子間相互作用2016
- Author(s)
  内海利男, 今井大達, 三好智博, 伊東孝祐
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-15K14472
[Presentation] A possible mechanism for small RNA processing by R. sphaeroides Argonaute2016
- Author(s)
  Tomohiro Miyoshi, Kosuke Ito, Ryo Murakami and Toshio Uchiumi
- Organizer
  RNA 2016
- Place of Presentation
  The International Conference Center in Kyoto
- Year and Date
  2016-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07246
[Presentation] Rhodobacter sphaeroides ArgonauteによるガイドRNA/ターゲットDNA認識機構の構造基盤2015
- Author(s)
  三好智博、伊東孝祐、村上僚、内海利男
- Organizer
  第17回日本RNA学会年会
- Place of Presentation
  ホテルライフォート札幌
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-25840019
[Presentation] リボソームサブユニット会合における翻訳開始因子IF5Bとリボソームストーク間相互作用の構造・機能基盤2015
- Author(s)
  村上僚、伊東孝祐、Jacob Morris、Leiming Tang、三好智博、浅野桂、内海利男
- Organizer
  第38回日本分子生物学学会・第88回日本生化学会大会合同大会
- Place of Presentation
  兵庫県、神戸市、神戸ポートアイランド
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-15K14472
[Presentation] 古細菌リボソームにおける種特異的な翻訳因子受容性をもたらす分子要因2015
- Author(s)
  須田真広、今井大達、三好智博、伊東孝祐、内海利男
- Organizer
  第38回日本分子生物学学会・第88回日本生化学会大会合同大会
- Place of Presentation
  兵庫県、神戸市、神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K14472
[Presentation] アルゴノート蛋白質によるガイド/ターゲット二本鎖の新結合様式2015
- Author(s)
  三好智博、伊東孝介、村上僚、内海利男
- Organizer
  第38回日本分子生物学学会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25840019
[Presentation] リボソームストークC末端と翻訳因子間の結合親和性の分析2015
- Author(s)
  丸山圭、三好智博、伊東孝祐、内海利男
- Organizer
  第38回日本分子生物学学会・第88回日本生化学会大会合同大会
- Place of Presentation
  兵庫県、神戸市、神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K14472
[Presentation] 翻訳終結段階および異常停止時におけるリボソームストークタンパク質のはたらき2015
- Author(s)
  今井大達、三好智博、伊東孝祐、内海利男
- Organizer
  第38回日本分子生物学学会・第88回日本生化学会大会合同大会
- Place of Presentation
  兵庫県、神戸市、神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K14472
[Presentation] RNA-guided DNA interferenceを担うArgonauteタンパク質2015
- Author(s)
  三好智博、伊東孝祐、村上僚、内海利男
- Organizer
  平成27年度日本生化学会関東支部例会
- Place of Presentation
  新潟日報メディアシップ
- Year and Date
  2015-06-20
- Data Source
  KAKENHI-PROJECT-25840019
[Presentation] リボソームストークタンパク質とeIF5Bの相互作用は翻訳開始反応におけるサブユニット会合を促進する2015
- Author(s)
  村上僚、Jacob Morris、Leiming Tang、三好智博、浅野桂、伊東孝祐、内海利男
- Organizer
  第17回日本RNA学会年会
- Place of Presentation
  北海道、札幌市、ホテルライフォート札幌
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-15K14472
[Presentation] Recognition mechanism of guide RNA-target DNA heterodupulex by Argonaute2015
- Author(s)
  Tomohiro Miyoshi, Kosuke Ito, Ryo Murakami, Toshio Uchiumi
- Organizer
  EMBL Symposium
- Place of Presentation
  EMBL Advanced Training Centre (Germany)
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25840019
[Presentation] リボトキシン作用に関与するリボソームP1/P2ダイマーの柔軟な機能構造2013
- Author(s)
  遊佐和之、三好智博、Ka-Ming Lee、Lai-On Chu, Conny Wing-Heng Yu, 大野萌、伊東孝祐、Pang-Chui Shaw, Kam-Bo Wong、内海利男
- Organizer
  第8回無細胞生命科学研究会
- Place of Presentation
  新潟大学
- Data Source
  KAKENHI-PROJECT-24370073
[Presentation] リボトキシン作用に関与するリボソームP1/P2ダイマーの柔軟な機能構造2013
- Author(s)
  遊佐和之、三好智博、Ka-Ming Lee、Lai-On Chu, Conny Wing-Heng Yu, 大野萌、伊東孝祐、Pang-Chui Shaw, Kam-Bo Wong、内海利男
- Organizer
  第8回　無細胞生命科学研究会
- Place of Presentation
  新潟大学
- Data Source
  KAKENHI-PROJECT-25840019
[Presentation] ヒトリボソームP0/P1/P2 ストークタンパク質が共有するC 末端部位と翻訳伸長因子間の相互作用2013
- Author(s)
  小野塚美穂, 馬場健太朗, 三好智博,　伊東孝祐,　内海利男
- Organizer
  第８回無細胞生命科学研究会
- Place of Presentation
  新潟大学
- Data Source
  KAKENHI-PROJECT-24370073
[Presentation] 好熱性古細菌翻訳因子によるin vitro翻訳系の確立2013
- Author(s)
  鈴木隆寛, 本田貴嘉, 村上僚, 佐藤駿平, 三好智博, 伊東孝祐, 内海利男
- Organizer
  日本Archaea研究会第26回講演会
- Place of Presentation
  東京工業大学
- Data Source
  KAKENHI-PROJECT-24370073
[Presentation] 真核生物リボソームストークタンパク質のC末端領域におけるリン酸化が及ぼす翻訳反応への影響2013
- Author(s)
  小野塚美穂,　馬場健太郎,　三好智博,　伊東孝祐,　内海利男
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-24370073
[Presentation] ハイブリッドリボソームを用いた古細菌翻訳伸長因子によるin vitroペプチド鎖伸長反応系の構築2013
- Author(s)
  鈴木隆寛, 三好智博, 村上僚, 佐藤駿平, 伊東孝祐, 内海利男
- Organizer
  第8 回無細胞生命科学研究会
- Place of Presentation
  新潟大学
- Data Source
  KAKENHI-PROJECT-24370073
[Presentation] Construction of in vitro Translation Elongation System with Archaeal Elongation Factors and Hybrid Ribosomes:Control of Interaction aEF-1A and Stalk aP1 by aEF-1B2012
- Author(s)
  Suzuki T, Honda T, Sato S, Miyoshi T, Ito K, Uchiumi T.
- Organizer
  日本分子生物学会
- Place of Presentation
  福岡国際会議場、マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-23770210
[Presentation] リボトキシンによるリボソーム不活性化作用への動物リボソームstalkタンパク質の関与2012
- Author(s)
  遊佐和之，三好智博，Ka-Ming Lee，大野萌，伊東孝祐，Kam-Bo Wong，内海利男
- Organizer
  新潟生化学懇話会
- Place of Presentation
  新潟大学（新潟市）
- Data Source
  KAKENHI-PROJECT-23770210
[Presentation] Evidence for Interaction of the C-terminal Region Shared by Human Ribosomal Stalk Proteins P0/P1/P2 with eEF-1A/eEF-22012
- Author(s)
  Onozuka, M., Baba, K., Miyoshi, T., Ito, K., Uchiumi, T.
- Organizer
  日本分子生物学会
- Place of Presentation
  福岡国際会議場、マリンメッセ福岡（福岡市）
- Data Source
  KAKENHI-PROJECT-23770210
[Presentation] The Hinge Regions of Eukaryotic Ribosomal Stalk Proteins are Indispensable for Efficient Depurination of 28S rRNA by Ribotoxins2012
- Author(s)
  Yusa K, Ohno M, Miyoshi T, Ito K, Uchiumi T.
- Organizer
  日本分子生物学会
- Place of Presentation
  福岡国際会議場、マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-23770210
[Presentation] Construction of in vitro Translation Elongation System with Archaeal Elongation Factors and Hybrid Ribosomes: Control of Interaction aEF-1A and Stalk aP1 by aEF-1B2012
- Author(s)
  Suzuki, T., Honda, T., Sato, S., Miyoshi, T., Ito, k., Uchiumi,. T.
- Organizer
  日本分子生物学会
- Place of Presentation
  福岡国際会議場、マリンメッセ福岡（福岡市）
- Data Source
  KAKENHI-PROJECT-23770210
[Presentation] Evidence for Interaction of the C-terminal Region Shared by Human Ribosomal Stalk Proteins P0/P1/P2 with eEF-1A/eEF-22012
- Author(s)
  Onozuka M, Baba K, Miyoshi T, Ito K,Uchiumi T.
- Organizer
  日本分子生物学会
- Place of Presentation
  福岡国際会議場、マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-23770210
[Presentation] The Hinge Regions of Eukaryotic Ribosomal Stalk Proteins are Indispensable for Efficient Depurination of 28S rRNA by Ribotoxins2012
- Author(s)
  Yusa, K., Ohno, M., Miyoshi, T., Ito, K., Uchiumi, T.
- Organizer
  日本分子生物学会
- Place of Presentation
  福岡国際会議場、マリンメッセ福岡（福岡市）
- Data Source
  KAKENHI-PROJECT-23770210
[Presentation] The C-terminal region of the ribosomal stalk protein is required for depurination at the SRL region of rRNA2012
- Author(s)
  Yusa K , Miyoshi T , Lee KM ,Maruyama R,Ohno M,Ito K,Wong KB,Uchiumi T.
- Organizer
  2012 Niigata Graduate Research Forum Research Camp
- Place of Presentation
  朱鷺メッセ
- Data Source
  KAKENHI-PROJECT-23770210
[Presentation] Introduction of a Lepidoptera-specific sequence within the GTPase-associated center of 28S rRNA into Escherichia coli 23S rRNA: Effects of the mutations2011
- Author(s)
  Ryo Maruyama, Kazuyuki Yusa, Masahiro Mochizuki, Tomohiro Miyoshi, Kosuke Ito, Takaomi Nomura, Uchiumi Toshio
- Organizer
  日本RNA学会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-23770210
[Presentation] リボトキシンによるrRNA機能部位の脱プリン作用にはリボソームstalkタンパク質のC末端部位が関与する2011
- Author(s)
  遊佐和之、三好智博、Ka-Ming Lee、円山亮、大野萌、伊東孝祐、Kam-Bo Wong、内海利男
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23770210
[Presentation] リボトキシンによるリボソーム不活性化作用への動物リボソームstalkタンパク質の関与2011
- Author(s)
  遊佐和之,三好智博,Ka-MingLee,大野萌,伊東孝祐,Kam-BoWong,内海利男
- Organizer
  新潟生化学懇話会
- Place of Presentation
  新潟大学
- Data Source
  KAKENHI-PROJECT-23770210
[Presentation] ショウジョウバエsmallRNA生合成機構の解明2011
- Author(s)
  三好智博
- Organizer
  新潟生化学懇話会
- Place of Presentation
  新潟薬科大学
- Year and Date
  2011-06-25
- Data Source
  KAKENHI-PROJECT-23770210
[Presentation] 立体構造解析に基づいたペプチジル tRNA 加水分解酵素の酵素学的機能解析
- Author(s)
  上原祐二、伊東孝祐、村上僚、松本愛弥、三好智博、清水義宏、竹本千重、横川隆志、上田卓也、内海利男
- Organizer
  第9回無細胞生命科学研究会
- Place of Presentation
  大阪大学医学部銀杏会館（大阪）
- Year and Date
  2014-10-08 – 2014-10-09
- Data Source
  KAKENHI-PROJECT-24370073
[Presentation] リボソームストークタンパク質と翻訳伸長因子 EF1α の機能的相互作用の構造基盤
- Author(s)
  伊東孝祐、本田貴嘉、鈴木隆寛、三好智博、村上僚、田中勲、姚閔、内海利男
- Organizer
  第16回日本RNA学会年会
- Place of Presentation
  ウインク愛知（名古屋）
- Year and Date
  2014-07-23 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-24370073
[Presentation] リボソームストーク C 末端領域は、翻訳因子の 23S rRNA sarcin/ricin loop へのリクルートに不可欠である
- Author(s)
  今井大達、三好智博、村上僚、鈴木隆寛、伊東孝祐、内海利男
- Organizer
  第16回日本RNA学会年会
- Place of Presentation
  ウインク愛知（名古屋）
- Year and Date
  2014-07-23 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-24370073
[Presentation] リボソームストークタンパク質と翻訳伸長因子EF1αの機能的相互作用の分子機構解析
- Author(s)
  伊東孝祐、鈴木隆寛、三好智博、村上僚、姚閔、内海利男
- Organizer
  第3回リボソームミーティング
- Place of Presentation
  ANAホリデイ・イン　リゾート宮崎（宮崎）
- Year and Date
  2015-03-17 – 2015-03-18
- Data Source
  KAKENHI-PROJECT-24370073
[Presentation] リボソームストークタンパク質による翻訳伸長因子の機能発現機構
- Author(s)
  今井大達、三好智博、村上僚、伊東孝祐、内海利男
- Organizer
  第3回リボソームミーティング
- Place of Presentation
  ANAホリデイ・イン　リゾート宮崎（宮崎）
- Year and Date
  2015-03-17 – 2015-03-18
- Data Source
  KAKENHI-PROJECT-24370073
[Presentation] 翻訳開始因子IF5Bとリボソームストーク複合体の相互作用解析
- Author(s)
  村上僚、今井大達、三好智博、伊東孝祐、内海利男
- Organizer
  第16回日本RNA学会年会
- Place of Presentation
  ウインク愛知（名古屋）
- Year and Date
  2014-07-23 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-24370073
[Presentation] リボソームストークと翻訳因子間相互作用研究の新展開
- Author(s)
  内海利男、鈴木隆寛、村上僚、今井大達、三好智博、伊東孝祐
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-11-25 – 2014-11-27
- Invited
- Data Source
  KAKENHI-PROJECT-24370073

1. ITO Kosuke (20502397)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
2. UCHIUMI Toshio (50143764)

# of Collaborated Projects: 3 results

# of Collaborated Products: 32 results
3. IMAMURA Yasuhiro (00339136)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 雪田聡 (80401214)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YAO Minn (40311518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. UCHIYAMA Susumu (90335381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Sato Hiroe (80705963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Yoshida Akihiro (20364151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
9. 石津大嗣 (40574588)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 阪本泰光 (00349036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 吉成伸夫 (20231699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
12. 宇田川信之 (70245801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 高橋晋平 (20805014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 十川紀夫 (30236153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 王宝禮 (20213613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Suda Masahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. IMAI Hirotatsu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 西川周一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 石野良純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 米澤大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyoshi Tomohiro 三好 智博

MIYOSHI Tomohiro 三好 智博

Research Projects

Research Products

Co-Researchers

Regulatory mechanisms of glucose metabolism by salivary protein for prevention and improvement of lifestyle-related disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel gene expression control system based on the prokaryotic ArgonautePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

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Elucidation of the mechanism of salivary protein for reducing adverse effects of steroids and suppressing virus-induced inflammation

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Association between acquisition of virulence factors and Argonaute protein in bacteriaPrincipal Investigator

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Elucidation of the molecular basis of leukotoxin-receptor interactions and development of a novel periodontitis vaccine.

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Research for the mechanism of DNA silencing using small RNA as a guide strandPrincipal Investigator

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Elucidation of the structural basis for the interaction of the ribosomal stalk protein with aminoacyl-tRNA synthetase

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A new method for producing site-specific anti-protein antibodies at will

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Structural basis for small RNA functional mechanism in eukaryotesPrincipal Investigator

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Ribosomal stalk complex driving translation cycle: molecular basis for high-speed and high-efficiency

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Analysis of maturation process of endo -siRNA precursorPrincipal Investigator

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[Journal Article] The natural bicyclic hexapeptide RA-VII is a novel inhibitor of the eukaryotic translocase eEF2.2022

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[Journal Article] Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis.2021

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Miyoshi Tomohiro 三好智博

MIYOSHI Tomohiro 三好智博