KANAI AKINORI 金井昭教

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KANAI Akinori 金井昭教

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Researcher Number	60549567
Other IDs
Affiliation (Current)	2025: 東京大学, 大学院新領域創成科学研究科, 特任准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 東京大学, 大学院新領域創成科学研究科, 特任准教授 2012 – 2020: 広島大学, 原爆放射線医科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 63020:Radiation influence-related / Risk sciences of radiation and chemicals Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Basic Section 52040:Radiological sciences-related / Basic Section 49010:Pathological biochemistry-related / Hematology / Basic Section 63040:Environmental impact assessment-related / Medium-sized Section 50:Oncology and related fields / Pathological medical chemistry
Keywords	Principal Investigator 放射線 / 次世代シーケンサー / 受精卵 / バイオインフォマティクス / 全ゲノム解析 / １細胞シーケンス / 1細胞 Except Principal Investigator 造血器腫瘍 / エピジェネティクス / モノソミー７ … More / MDS / 骨髄異形成症候群 / 分子標的療法 / 分子標的薬 / 白血病 / 炎症 / p53 / 造血障害 / Samd9/9L / Samd9／9L / 遺伝子発現制御 / Samd9/L / エンドソーム / ヒストン修飾 / 分子標的創薬 / 抗炎症剤 / 放射線併用抗腫瘍薬 / 放射線防護剤 / 微少環境 / 老化 / 変異 / 放射線発がん、化学発がん / 微小環境 / モデルマウス / 幹細胞 / 低線量・低線量率 / 放射線発がん / DOT1L / MOZ / 自己複製 / AF10 / 染色体転座 / 転写 / NEDD化 / タンパク質翻訳後修飾 / MLL / Wilms腫瘍 / ENL / 腎腫瘍 / 遅発性放射線腸管障害 / 5-クロロ-8-キノリノール / 放射線腸管障害 / 血管内皮損傷 / 放射線骨髄障害 / オルトバナジン酸ナトリウム / 遅発性腸管障害 / 血管内皮 / バナデート / インターフェロン / Monosomo-7 / monosomy 7 / Samd9/9L症候群 / TGFbeta / 先天性造血不全症候群 / モノソミー7 / SAMD9/SAMD9L症候群 / エンドソーム交通 / 表面受容体代謝 / トランスフェリン / サイトカイン受容体 / 受容体代謝 / サイトカイン / 造血不全 / 発現制御 / 遺伝子 / 癌 / haploinsufficiency / Miki / Samd9 / 中心体成熟不全 / Haploinsufficiency / 細胞遊走能 / 7番染色体 / RAEB / 次世代シーケンサー / 次世代シーケンサー解析 / DNAメチル化 / エピゲノム Less

Role of deregulated neddylation in acute myeloid leukemia
- Principal Investigator
  
  上田健
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kindai University
Development of Combination Radiation Therapy Drugs to Improve Cancer Control Rates by Regulating DNA Damage Response Molecules
- Principal Investigator
  
  森田明典
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  The University of Tokushima
Development of novel therapies for ENL-mutated Wilms tumor
- Principal Investigator
  
  横山明彦
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  National Cancer Center Japan
Mechanisms of AF10-rearranged leukemia
- Principal Investigator
  
  横山明彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  National Cancer Center Japan
幹細胞の可視化によるがん化プロセス解析マウスモデルを用いた放射線発がん機構の解明
- Principal Investigator
  
  笹谷めぐみ (豊島めぐみ)
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63040:Environmental impact assessment-related
- Research Institution
  Hiroshima University
Molecular mechanisms through which SAMD9/9L mutants cause bone marrow failure
- Principal Investigator
  
  INABA Toshiya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Hiroshima University
A novel radioprotective mechanism of sodium orthovanadate and its application to radiotherapy
- Principal Investigator
  
  NISHIYAMA Yuichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  The University of Tokushima
Analysis of Trim43 in radiation-induced arrest of fertilized egg developmentPrincipal Investigator
- Principal Investigator
  
  Kanai Akinori
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  The University of Tokyo
Elucidation of the novel epigenetic mechanism promoting a subset of hematologic malignancies
- Principal Investigator
  
  UEDA Takeshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kindai University
The effects of ionizing radiation on early development stage of the fertilized eggPrincipal Investigator
- Principal Investigator
  
  Kanai Akinori
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Hiroshima University
Abnormal endosomal traffic induced by Samd9/9L causing myelodysplastic syndromes and inherited bone marrow failure
- Principal Investigator
  
  Inaba Toshiya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Hiroshima University
Context-dependent regulation of histone methylation in a subset of hematologic malignancies
- Principal Investigator
  
  UEDA Takeshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kindai University
Analysis of radiation induced mutation patterns and frequencies with whole genome sequencingPrincipal Investigator
- Principal Investigator
  
  Kanai Akinori
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Hiroshima University
Elucidation of molecular mechanism through which MDS develops
- Principal Investigator
  
  Inaba Toshiya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Hiroshima University
Analysis of radiation induced mutations using next generation sequencerPrincipal Investigator
- Principal Investigator
  
  KANAI Akinori
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Hiroshima University
DNA demethylation facilitates globin translation in myelodysplastic syndrome
- Principal Investigator
  
  MATSUI HIROTAKA
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Hiroshima University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Other

[Journal Article] MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain2023
- Author(s)
  Becht Dustin C.、Klein Brianna J.、Kanai Akinori、Jang Suk Min、Cox Khan L.、Zhou Bing-Rui、Phanor Sabrina K.、Zhang Yi、Chen Ruo-Wen、Ebmeier Christopher C.、Lachance Catherine、Galloy Maxime、Fradet-Turcotte Amelie、Bulyk Martha L.、Bai Yawen、Poirier Michael G.、C?t? Jacques、Yokoyama Akihiko、Kutateladze Tatiana G.
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1-20
- DOI
  10.1038/s41467-023-36368-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-23K24368
[Journal Article] MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins2023
- Author(s)
  Komata Yosuke、Kanai Akinori、Maeda Takahiro、Inaba Toshiya、Yokoyama Akihiko
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1-17
- DOI
  10.1038/s41467-023-37712-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-20H05699, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-23K24368
[Journal Article] Ribosome profiling analysis reveals the roles of DDX41 in translational regulation2023
- Author(s)
  Tungalag Saruul、Shinriki Satoru、Hirayama Mayumi、Nagamachi Akiko、Kanai Akinori、Inaba Toshiya、Matsui Hirotaka
- Journal Title
  
  International Journal of Hematology
  
  Volume: - Issue: 6 Pages: 1-13
- DOI
  10.1007/s12185-023-03558-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K12239, KAKENHI-PROJECT-22K10195, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-22K17187, KAKENHI-PROJECT-21K08395, KAKENHI-PROJECT-21K08419
[Journal Article] DDX41 expression is associated with tumor necrosis in clear cell renal cell carcinoma and in cooperation with VHL loss leads to worse prognosis2022
- Author(s)
  Kobatake Kohei、Ikeda Kenichiro、Nakata Yuichiro、Yamasaki Norimasa、Kanai Akinori、Sekino Yohei、Takemoto Kenshiro、Fukushima Takafumi、Babasaki Takashi、Kitano Hiroyuki、Goto Keisuke、Hayashi Tetsutaro、Sentani Kazuhiro、Teishima Jun、Kaminuima Osamu、Hinata Nobuyuki
- Journal Title
  
  Urologic Oncology: Seminars and Original Investigations
  
  Volume: 40 Issue: 10 Pages: 456.e9-456.e18
- DOI
  10.1016/j.urolonc.2022.07.001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K12239, KAKENHI-PROJECT-22K06959, KAKENHI-PROJECT-20K18143
[Journal Article] Low-Dose-Rate Irradiation Suppresses the Expression of Cell Cycle-Related Genes, Resulting in Modification of Sensitivity to Anti-Cancer Drugs2022
- Author(s)
  Shimabukuro K, Fukazawa T, Kanai A, Kawai H, Mekata K, Hirohashi N, Kakimoto N, Tanimoto K.
- Journal Title
  
  Cells
  
  Volume: 11(3) Issue: 3 Pages: 501-501
- DOI
  10.3390/cells11030501
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12322, KAKENHI-PROJECT-20K20310, KAKENHI-PROJECT-21K10073, KAKENHI-PROJECT-21K12239
[Journal Article] DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells2022
- Author(s)
  Satoru Shinriki;Mayumi Hirayama;Akiko Nagamachi;Akihiko Yokoyama;Takeshi Kawamura;Akinori Kanai;Hidehiko Kawai;Junichi Iwakiri;Rin Liu;Manabu Maeshiro;Saruul Tungalag;Masayoshi Tasaki;Mitsuharu Ueda;Kazuhito Tomizawa;Naoyuki Kataoka;Takashi Ideue;Yutaka Suzuki;Kiyoshi Asai;Tokio Tani;Toshiya Inaba;Hirotaka Matsui
- Journal Title
  
  Leukemia
  
  Volume: 36 Issue: 11 Pages: 2605-2620
- DOI
  10.1038/s41375-022-01708-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06174, KAKENHI-PROJECT-21K08395, KAKENHI-PROJECT-21K08419, KAKENHI-PROJECT-21K12239, KAKENHI-PROJECT-22K10195, KAKENHI-PROJECT-22K12375, KAKENHI-PROJECT-22K20997, KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-20K12041, KAKENHI-PROJECT-23K24368
[Journal Article] Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia2022
- Author(s)
 Tanaka Atsushi、Kunimoto Hiroyoshi et al.
- Journal Title
 
 Blood
 
 Volume: 140 Issue: 8 Pages: 875-888
- DOI
 10.1182/blood.2021015325
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-21K08400, KAKENHI-PROJECT-21K08432, KAKENHI-PROJECT-21K12239, KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H03714, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-21J15620, KAKENHI-PROJECT-20H03717, KAKENHI-PROJECT-23K24368
[Journal Article] Successful Cord Blood Transplantation for Idiopathic CD4+ Lymphocytopenia2021
- Author(s)
 Yamamoto Keita、Najima Yuho、Iizuka Hiroko、Harada Yuka、Sadato Daichi、Kanai Akinori、Matsui Hirotaka、Inamoto Kyoko、Mukae Junichi、Shingai Naoki、Toya Takashi、Igarashi Aiko、Shimizu Hiroaki、Kobayashi Takeshi、Kakihana Kazuhiko、Sakamaki Hisashi、Ohashi Kazuteru、Harada Hironori、Doki Noriko
- Journal Title
 
 Acta Haematologica
 
 Volume: 144 Issue: 6 Pages: 698-705
- DOI
 10.1159/000516347
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-19K08824, KAKENHI-PROJECT-20K07840, KAKENHI-PROJECT-21K08419, KAKENHI-PROJECT-21K12239, KAKENHI-PROJECT-19H04355
[Journal Article] HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways2021
- Author(s)
  Miyamoto R, Kanai A, Okuda H, Komata Y, Takahashi S, Matsui H, Inaba T, *Yokoyama A.
- Journal Title
  
  eLife
  
  Volume: 10
- DOI
  10.7554/elife.64148
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03694, KAKENHI-PROJECT-21K08419, KAKENHI-PROJECT-21K12239
[Journal Article] KDM4B promotes acute myeloid leukemia associated with AML1‐ETO by regulating chromatin accessibility2021
- Author(s)
  Ueda Takeshi、Kanai Akinori、Komuro Akiyoshi、Amano Hisayuki、Ota Kazushige、Honda Masahiko、Kawazu Masahito、Okada Hitoshi
- Journal Title
  
  FASEB BioAdvances
  
  Volume: 3 Issue: 12 Pages: 1020-1033
- DOI
  10.1096/fba.2021-00030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11486, KAKENHI-PLANNED-17H06404, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-20K07346, KAKENHI-PROJECT-21K06829, KAKENHI-PROJECT-21K07135, KAKENHI-PROJECT-21K12239
[Journal Article] HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis2021
- Author(s)
  akahashi S, Kanai A, Okuda H, Miyamoto R, Komata Y, Kawamura T, Matsui H, Inaba T, Takaori-Kondo A, *Yokoyama A
- Journal Title
  
  eLife
  
  Volume: 10
- DOI
  10.7554/elife.65872
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03694, KAKENHI-PROJECT-21K08419, KAKENHI-PROJECT-21K12239
[Journal Article] Multi-organ failure with abnormal receptor metabolism in mice mimicking Samd9/9L syndromes2021
- Author(s)
  Nagamachi A, Kanai A, Nakamura M, Okuda H, Yokoyama A, Shinriki S, Matsui H, Inaba T.
- Journal Title
  
  J Clin Invest
  
  Volume: 131 Issue: 4 Pages: 1-16
- DOI
  10.1172/jci140147
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10360, KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-18K08334, KAKENHI-PROJECT-18K08357, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19H03694, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-21K08395
[Journal Article] UTX maintains functional integrity of murine hematopoietic system by globally regulating aging-associated genes.2021
- Author(s)
  Sera Y; Nakata Y; Ueda T; Yamasaki N; Koide S; Kobayashi H; Ikeda KI; Kobatake K; Iwasaki M; Oda H; Wolff L; Kanai A; Nagamachi A; Inaba T; Sotomaru Y; Ichinohe T; Koizumi M; Miyakawa Y; Honda ZI; Iwama A; Suda T; Takubo K; Honda H
- Journal Title
  
  Blood.
  
  Volume: 137 Issue: 7 Pages: 908-922
- DOI
  10.1182/blood.2019001044
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07346, KAKENHI-PROJECT-19K22546, KAKENHI-PROJECT-19K17918, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-18K08357, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-19H01056, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-21K08378, KAKENHI-PROJECT-21K08395
[Journal Article] Overexpression of Hmga2 activates Igf2bp2 and remodels transcriptional program of Tet2-deficient stem cells in myeloid transformation2021
- Author(s)
  Bai Jie、Yokomizo-Nakano Takako、Kubota Sho、Sun Yuqi、Kanai Akinori、Iimori Mihoko、Harada Hironori、Iwama Atsushi、Sashida Goro
- Journal Title
  
  Oncogene
  
  Volume: 40 Issue: 8 Pages: 1531-1541
- DOI
  10.1038/s41388-020-01629-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08824, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19K08842, KAKENHI-PROJECT-19H04355, KAKENHI-PROJECT-21K19512
[Journal Article] Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction2020
- Author(s)
  Kobatake Kohei et al., Honda Zen-ichiro et al. and Honda Hiroaki
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 26 Issue: 8 Pages: 2065-2079
- DOI
  10.1158/1078-0432.ccr-19-2230
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08384, KAKENHI-PROJECT-19K07434, KAKENHI-PROJECT-19K17918, KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-19K09729, KAKENHI-PROJECT-20K07346, KAKENHI-PROJECT-19K22546, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19H01056
[Journal Article] Activation of CpG-Rich Promoters Mediated by MLL Drives MOZ-Rearranged Leukemia2020
- Author(s)
  Miyamoto Ryo、Okuda Hiroshi、Kanai Akinori、Takahashi Satoshi、Kawamura Takeshi、Matsui Hirotaka、Kitamura Toshio、Kitabayashi Issay、Inaba Toshiya、Yokoyama Akihiko
- Journal Title
  
  Cell Reports
  
  Volume: 32 Issue: 13 Pages: 108200-108200
- DOI
  10.1016/j.celrep.2020.108200
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00537, KAKENHI-PROJECT-18K08334, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19K16791, KAKENHI-PROJECT-19H03694
[Journal Article] GLIS1, a novel hypoxia-inducible transcription factor, promotes breast cancer cell motility via activation of WNT5A.2020
- Author(s)
  Kazumi Shimamoto, Keiji Tanimoto*, Takahiro Fukazawa, Hideaki Nakamura, Akinori Kanai, Hidemasa Bono, Hiromasa Ono, Hidetaka Eguchi, Nobuyuki Hirohashi
- Journal Title
  
  Carcinogenesis
  
  Volume: inpress Issue: 9 Pages: 1184-1194
- DOI
  10.1093/carcin/bgaa010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09768, KAKENHI-PROJECT-17K10561, KAKENHI-PROJECT-18K18196
[Journal Article] HHEX promotes myeloid transformation in cooperation with mutant ASXL1.2020
- Author(s)
  Takeda R, Asada S, Park SJ, Yokoyama A, Becker H, Kanai A, Visconte V, Hershberger C, Hayashi Y, Yonezawa T, Tamura M, Fukushima T, Tanaka Y, Fukuyama T, Matsumoto A, Yamasaki S, Nakai K, Yamazaki S, Inaba T, Shibata T, Inoue D, Honda H, Goyama S, Maciejewski J, Kitamura T.
- Journal Title
  
  Blood
  
  Volume: 136 Pages: 1670-1684
- DOI
  10.1182/blood.2019004613
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22546, KAKENHI-PROJECT-19KK0216, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-20H00537, KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-19J01570, KAKENHI-PROJECT-18K18196
[Journal Article] Characterization of a Novel Murine Colon Carcinoma Subline with High-Metastatic Activity Established by In Vivo Selection Method2020
- Author(s)
  Ma Liqiu、Sakamoto Yoshimitsu、Kanai Akinori、Otsuka Hiromi、Takahashi Akihisa、Kakimi Kazuhiro、Imai Takashi、Shimokawa Takashi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 8 Pages: 2829-2829
- DOI
  10.3390/ijms21082829
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18196
[Journal Article] Overexpression of RUNX3 Represses RUNX1 to Drive Transformation of Myelodysplastic Syndrome2020
- Author(s)
  Yokomizo-Nakano Takako、Kubota Sho、Bai Jie、Hamashima Ai、Morii Mariko、Sun Yuqi、Katagiri Seiichiro、Iimori Mihoko、Kanai Akinori、Tanaka Daiki、Oshima Motohiko、Harada Yuka、Ohyashiki Kazuma、Iwama Atsushi、Harada Hironori、Osato Motomi、Sashida Goro
- Journal Title
  
  Cancer Research
  
  Volume: 80 Issue: 12 Pages: 2523-2536
- DOI
  10.1158/0008-5472.can-19-3167
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08824, KAKENHI-PROJECT-20K07840, KAKENHI-PROJECT-19K16811, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K16090, KAKENHI-PROJECT-18K18196
[Journal Article] Identification of novel methylation markers in HPV-associated oropharyngeal cancer: genome-wide discovery, tissue verification and validation testing in ctDNA.2020
- Author(s)
  Misawa K, Imai A, Matsui H, Kanai A, Misawa Y, Mochizuki D, Mima M, Yamada S, Kurokawa T, Nakagawa T and Mineta H
- Journal Title
  
  Oncogene
  
  Volume: 39(24) Issue: 24 Pages: 4741-4755
- DOI
  10.1038/s41388-020-1327-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09689, KAKENHI-PROJECT-19K18722, KAKENHI-PROJECT-20K18250, KAKENHI-PROJECT-20K18277, KAKENHI-PROJECT-18K08334, KAKENHI-PROJECT-18K18196
[Journal Article] Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia2019
- Author(s)
  Hosokawa K, Mizumaki H, Elbadry M, Saito C, Espinoza JL, An DTT, Katagiri T, Harashima A, Kikuchi A, Kanai A, Matsui H, Inaba T, Taniwaki M, Yamamoto Y, Nakao S
- Journal Title
  
  Leukemia
  
  Volume: 33 Issue: 11 Pages: 2732-2766
- DOI
  10.1038/s41375-019-0510-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06889, KAKENHI-PROJECT-18K07551, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19K17823, KAKENHI-PROJECT-19H03686, KAKENHI-PROJECT-17K09007, KAKENHI-PROJECT-17K09822
[Journal Article] Lineage-specific RUNX2 super-enhancer activates MYC via a chromosomal translocation and promotes the development of blastic plasmacytoid dendritic cell neoplasm2019
- Author(s)
  Kubota S, Tokunaga K, Umezu T, Yokomizo-Nakano T, Oshima M, Tan KT, Yang H, Kanai A. Iwanaga E, Asou N, Maeda T, Nakagata N. Ito T, Iwama A. Ohyashiki K, Osato M, Sashida G.
- Journal Title
  
  Nat Commun
  
  Volume: 10 Issue: 1 Pages: 1653-1653
- DOI
  10.1038/s41467-019-09710-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18K07244, KAKENHI-PROJECT-19K07668, KAKENHI-PROJECT-19K22640, KAKENHI-PROJECT-18K16090, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-17J02389
[Journal Article] Intense Expression of EGFR L858R Characterizes the Micropapillary Component and L858R Is Associated with the Risk of Recurrence in pN0M0 Lung Adenocarcinoma with the Micropapillary Component2019
- Author(s)
  Kishi Naoto、Ito Masaoki、Miyata Yoshihiro、Kanai Akinori、Handa Yoshinori、Tsutani Yasuhiro、Kushitani Kei、Takeshima Yukio、Okada Morihito
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 27 Issue: 3 Pages: 945-955
- DOI
  10.1245/s10434-019-07854-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K18196
[Journal Article] A cell-based high-throughput screening method to directly examine transthyretin amyloid fibril formation at neutral pH2019
- Author(s)
  Ueda Mitsuharu、Okada Masamitsu、Mizuguchi Mineyuki、et al.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 29 Pages: 11259-11275
- DOI
  10.1074/jbc.ra119.007851
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07502, KAKENHI-PROJECT-18K08334, KAKENHI-PROJECT-19K10360, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-17H03570, KAKENHI-PROJECT-19H03379, KAKENHI-PROJECT-19H03565, KAKENHI-PROJECT-18K15455
[Journal Article] Kinetics of cytokine receptor internalization under steady-state conditions affects growth of neighboring blood cells.2019
- Author(s)
  Nagamachi A, Kikuchi J, Kanai A, Furukawa Y, Inaba T.
- Journal Title
  
  Haematologica
  
  Volume: in press Issue: 7 Pages: 1-14
- DOI
  10.3324/haematol.2019.232959
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-17K09938, KAKENHI-PROJECT-20K08761
[Journal Article] BRD4-Regulated Molecular Targets in Mantle Cell Lymphoma: Insights into Targeted Therapeutic Approach2019
- Author(s)
  TSUKAMOTO TAKU、NAKAHATA SHINGO、SATO RYUICHI、KANAI AKINORI、NAKANO MASAKAZU、CHINEN YOSHIAKI、MAEGAWA-MATSUI SAORI、MATSUMURA-KIMOTO YAYOI、TAKIMOTO-SHIMOMURA TOMOKO、MIZUNO YOSHIMI、KUWAHARA-OTA SAEKO、KAWAJI YUKA、TANIWAKI MASAFUMI、INABA TOSHIYA、TASHIRO KEI、MORISHITA KAZUHIRO、KURODA JUNYA
- Journal Title
  
  Cancer Genomics - Proteomics
  
  Volume: 17 Issue: 1 Pages: 77-89
- DOI
  10.21873/cgp.20169
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-17H04046, KAKENHI-PROJECT-18H02838
[Journal Article] High fat diet triggers a reduction in body fat mass in female mice deficient for Utx demethylase2019
- Author(s)
  Ota K, Komuro A, Amano H, Kanai A, Ge K, Ueda T, Okada H
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 10036-10036
- DOI
  10.1038/s41598-019-46445-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06941, KAKENHI-PROJECT-18K07211, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-17K08679
[Journal Article] Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation2018
- Author(s)
  Nagase R, Inoue D, Pastore A, Fujino T, Hou HA, Yamasaki N, Goyama S, Saika M, Kanai A, Sera Y, Horikawa S, Ota Y, Asada S, Hayashi Y, Kawabata KC, Takeda R, Tien HF, Honda H, Abdel-Wahab O, Kitamura T.
- Journal Title
  
  The Journal of Experimental Medicine
  
  Volume: 印刷中 Issue: 6 Pages: 1729-1747
- DOI
  10.1084/jem.20171151
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05634, KAKENHI-PROJECT-15H04855, KAKENHI-PROJECT-18K18196, KAKENHI-ORGANIZER-26115001, KAKENHI-PROJECT-17J05696, KAKENHI-INTERNATIONAL-15K21751
[Journal Article] A novel ASXL1?OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies2018
- Author(s)
  Inoue D, Fujino T, Sheridan P, Zhang YZ, Nagase R, Horikawa S, Li Z, Matsui H, Kanai A, Saika M, Yamaguchi R, Kozuka-Hata H, Kawabata KC, Yokoyama A, Goyama S, Inaba T, Imoto S, Miyano S, Xu M, Yang FC, Oyama M, Kitamura T.
- Journal Title
  
  Leukemia
  
  Volume: 印刷中 Issue: 6 Pages: 1327-1337
- DOI
  10.1038/s41375-018-0083-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05634, KAKENHI-PROJECT-15H04855, KAKENHI-PROJECT-15H04857, KAKENHI-PROJECT-16H05337, KAKENHI-PROJECT-18K18196, KAKENHI-PLANNED-16H06578, KAKENHI-PROJECT-18H02838
[Journal Article] Ezh2 loss propagates hypermethylation at T cell differentiation?regulating genes to promote leukemic transformation2018
- Author(s)
  Wang Changshan、Oshima Motohiko、Sato Daisuke、Matsui Hirotaka、Kubota Sho、Aoyama Kazumasa、Nakajima-Takagi Yaeko、Koide Shuhei、Matsubayashi Jun、Mochizuki-Kashio Makiko、Nakano-Yokomizo Takako、Bai Jie、Nagao Toshitaka、Kanai Akinori、Iwama Atsushi、Sashida Goro
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 128 Issue: 9 Pages: 3872-3886
- DOI
  10.1172/jci94645
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08705, KAKENHI-PROJECT-18K08348, KAKENHI-PROJECT-18K18196, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-16KT0113, KAKENHI-PROJECT-18K16078, KAKENHI-PROJECT-16H06276
[Journal Article] Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes.2017
- Author(s)
  Kojo S, Tanaka H, Endo TA, Muroi S, Liu Y, Seo W, Tenno M, Kakugawa K, Naoe Y, Nair K, Moro K, Katsuragi Y, Kanai A, Inaba T, Egawa T, Venkatesh B, Minoda A, Kominami R, Taniuchi I.
- Journal Title
  
  Nat Commun.
  
  Volume: 8 Issue: 1 Pages: 702-702
- DOI
  10.1038/s41467-017-00768-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19696, KAKENHI-PUBLICLY-17H05805, KAKENHI-PROJECT-15H04857, KAKENHI-PROJECT-15K08291, KAKENHI-PROJECT-16K15362, KAKENHI-PROJECT-15K08535
[Journal Article] Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency.2017
- Author(s)
  Ikeda K, Ueda T, Yamasaki N, Nakata Y,Sera Y, Nagamachi A,Miyama T, Kobayashi H, Takubo K, Kanai A, Oda H, Wolff L, Honda Zi, Ichinohe T, Matsubara A, Suda T, Inaba T, Honda H.
- Journal Title
  
  Sci. Rep.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04857
[Journal Article] Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia.2017
- Author(s)
  Nakata Y, Ueda U, Nagamachi A, Yamasaki N, Ikeda K, Sera Y, Takubo K, Kanai A, Oda H, Sanada M, Ogawa S, Tsuji K, Ebihara Y, Wolff L, Honda Z, Suda T, Inaba T, Honda H.
- Journal Title
  
  Blood
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04857
[Journal Article] A novel LSD1 inhibitor NCD38 ameliorates MDS-related leukemia with complex karyotype by attenuating leukemia programs via activating super-enhancers.2017
- Author(s)
  Sugino N, Kawahara M, Tatsumi G, Kanai A, Matsui H, Yamamoto R, Nagai Y, Fujii S, Shimazu Y, Hishizawa M, Inaba T, Andoh A, Suzuki T, Takaori-Kondo A.
- Journal Title
  
  Leukemia
  
  Volume: in press Issue: 11 Pages: 2303-2314
- DOI
  10.1038/leu.2017.59
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01513, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-16K09846, KAKENHI-PUBLICLY-17H05649, KAKENHI-PROJECT-15H04857, KAKENHI-PROJECT-15K09478
[Journal Article] Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia2017
- Author(s)
  Nakata Y, Ueda T, Nagamachi A, Yamasaki N, Ikeda KI, Sera Y, Takubo K, Kanai A, Oda H, Sanada M, Ogawa S, Tsuji K, Ebihara Y, Wolff L, Honda ZI, Suda T, Inaba T, Honda H.
- Journal Title
  
  Blood
  
  Volume: 129 Issue: 15 Pages: 2148-2160
- DOI
  10.1182/blood-2016-06-724658
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-17K08679, KAKENHI-PROJECT-15H04857, KAKENHI-PROJECT-17J05696, KAKENHI-PROJECT-16K19575
[Journal Article] H-NS Facilitates Sequence Diversification of Horizontally Transferred DNAs during Their Integration in Host Chromosomes2016
- Author(s)
  Higashi K., Tobe T., Kanai A., Uyar E., Ishikawa S., Suzuki Y., Ogasawara N., Kurokawa K., and Oshima T
- Journal Title
  
  PLoS genetics
  
  Volume: 12 Issue: 1 Pages: e1005796-e1005796
- DOI
  10.1371/journal.pgen.1005796
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26450090, KAKENHI-PROJECT-15K16125, KAKENHI-PLANNED-26106004, KAKENHI-PROJECT-25292206
[Journal Article] ALKR1275Q perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN.2016
- Author(s)
  Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda K, Sera Y, Honda ZI, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, Honda H.
- Journal Title
  
  Oncogene.
  
  Volume: 無 Issue: 34 Pages: 4447-4458
- DOI
  10.1038/onc.2015.519
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-25460416, KAKENHI-PROJECT-15K14384, KAKENHI-PROJECT-26670493, KAKENHI-PROJECT-25293184, KAKENHI-PROJECT-26293242, KAKENHI-PROJECT-26293227, KAKENHI-PROJECT-16K08691
[Journal Article] The loss of Ezh2 cooperates with an active JAK2 mutant in the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.2016
- Author(s)
  Sashida G, Wang S, Tomioka T, Oshima M, Kazumasa Aoyama K, Kanai A, Mochizuki-Kashio M, Harada H, Shimoda K, Iwama A.
- Journal Title
  
  J Experimenta l Medicine
  
  Volume: 213 Issue: 8 Pages: 1459-1477
- DOI
  10.1084/jem.20151121
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-15H03137, KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-16KT0113, KAKENHI-PROJECT-15K09460, KAKENHI-PROJECT-16K09831, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
[Journal Article] Propagation of tri-methylated H3K27 regulated by EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression.2016
- Author(s)
  Ueda T, Nakata Y, Nagamachi A, Yamasaki N, Kanai A, Matsui H, Honda ZI, Oda H, Wolff L, Inaba T, Honda H.
- Journal Title
  
  PNAS
  
  Volume: 113(37) Issue: 37 Pages: 10370-10375
- DOI
  10.1073/pnas.1600070113
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01513, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-26293227, KAKENHI-PROJECT-26460391, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-15K09478, KAKENHI-PROJECT-16K19575
[Journal Article] Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency2016
- Author(s)
  Ikeda K-I, Ueda T, Yamasaki N, Nakata Y, Sera Y, Nagamachi A, Miyama T, Kobayashi H, TakuboK, Kanai A, Oda H, Wolff l, Honda Z-1, Ichinohe T, Matsubara A, Suda T, Inaba T, Honda H
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 29454-29454
- DOI
  10.1038/srep29454
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-26293227, KAKENHI-PROJECT-26460391, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-16K19575
[Journal Article] Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2.2015
- Author(s)
  Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K, Konuma T, Oda H, Wolff L, Honda ZI, Wu X, Helin K, Iwama A, Suda T, Inaba T, Honda H.
- Journal Title
  
  Blood
  
  Volume: 125 Pages: 3437-3446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04857
[Journal Article] Fbxl10 overexpression in murine hematopoietic stemcells induces leukemia involving metabolic activation and upregulation of Nsg22015
- Author(s)
  Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K Konuma T, Oda H, Wolff L, Honda Z, Wu X, Helin K, Iwama A, Suda T, Inaba T, Honda H.
- Journal Title
  
  Blood
  
  Volume: 125 Issue: 22 Pages: 3437-3446
- DOI
  10.1182/blood-2014-03-562694
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460391, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-26860735, KAKENHI-PROJECT-26293227
[Journal Article] AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription.2015
- Author(s)
  Okuda H, Kanai A, Ito S, Matsui H, Yokoyama A.
- Journal Title
  
  Nat Commun.
  
  Volume: 23;6 Issue: 1
- DOI
  10.1038/ncomms9869
- NAID
  120005672585
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K16125
[Journal Article] MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters2014
- Author(s)
  Okuda H, Kawaguchi M, Kanai A, Matsui H, Kawamura T, Inaba T, Kitabayashi I, Yokoyama A
- Journal Title
  
  Nucleic Acid Research
  
  Volume: 未定 Issue: 7 Pages: 1-16
- DOI
  10.1093/nar/gkt1394
- NAID
  120005439160
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22118003, KAKENHI-PROJECT-23689050, KAKENHI-PROJECT-24591397, KAKENHI-PUBLICLY-25118511, KAKENHI-PROJECT-25670450, KAKENHI-PROJECT-25870373
[Journal Article] Novel functional small RNAs are selectively loaded onto mammalian Ago12014
- Author(s)
  Yamakawa, N. Okuyama, K. Ogata, J. Kanai, A. Helwak, A. Takamatsu, M. Imadome, K. I. Takakura, K. Chanda, B. Kurosaki, N. Yamamoto, H. Ando, K. Matsui, H. Inaba, T. Kotani, A.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 未確定 Issue: 8 Pages: 5289-5301
- DOI
  10.1093/nar/gku137
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591397, KAKENHI-PUBLICLY-25118726, KAKENHI-PROJECT-25640070, KAKENHI-PROJECT-26830115
[Journal Article] Ultradeep sequencing study of chronic hepatitis C virus genotype 1 infection in patients treated with daclatasvir, peginterferon, and ribavirin2014
- Author(s)
  Murakami, E. Imamura, M. Hayes, C. N. Abe, H. Hiraga, N. Honda, Y. Ono, A. Kosaka, K. Kawaoka, T. Tsuge, M. Aikata, H. Takahashi, S. Miki, D. Ochi, H. Matsui, H. Kanai, A. Inaba, T. McPhee, F. Chayama, K.
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 58 Issue: 4 Pages: 2105-2112
- DOI
  10.1128/aac.02068-13
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591397, KAKENHI-PROJECT-24790701, KAKENHI-PROJECT-24790702, KAKENHI-PROJECT-26461008, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536
[Journal Article] Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice2013
- Author(s)
  Shi, N. Hiraga, N. Imamura, M. Hayes, C. N. Zhang, Y. Kosaka, K. Okazaki, A. Murakami, E. Tsuge, M. Abe, H. Aikata, H. Takahashi, S. Ochi, H. Tateno-Mukaidani, C. Yoshizato, K. Matsui, H. Kanai, A. Inaba, T. McPhee, F. Gao, M. Chayama, K.
- Journal Title
  
  Gut
  
  Volume: 62 Issue: 7 Pages: 1055-1061
- DOI
  10.1136/gutjnl-2012-302600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591397, KAKENHI-PROJECT-24790702, KAKENHI-PROJECT-25670369, KAKENHI-PLANNED-22118005
[Journal Article] Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.2013
- Author(s)
  Nagamachi A
- Journal Title
  
  Cancer Cell
  
  Volume: 24 Issue: 3 Pages: 305-317
- DOI
  10.1016/j.ccr.2013.08.011
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130004, KAKENHI-PROJECT-23240125, KAKENHI-PROJECT-23249053, KAKENHI-PROJECT-23390252, KAKENHI-PROJECT-23689049, KAKENHI-PROJECT-24591397, KAKENHI-PUBLICLY-25118724, KAKENHI-PROJECT-25550030, KAKENHI-PROJECT-25640065
[Presentation] Single cell spatial transcriptome analysis of LCNEC (Lung Cancer) using STOmics2023
- Author(s)
  Akinori Kanai, Ryota Matsuoka, Daisuke Matsubara, Ayako Suzuki, Yutaka Suzuki
- Organizer
  第14回国際ゲノム会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K12239
[Presentation] 1細胞空間遺伝子発現解析STOmicsによる肺がん(LCNEC)解析2023
- Author(s)
  金井昭教、松岡亮太、松原大祐、鈴木絢子、鈴木穣
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K12239
[Presentation] 炎症誘発性プラットフォームを標的とする放射線防護剤の開発2023
- Author(s)
  森田明典、谷本大河、東優一、西山祐一、昌子紡己、村田貴嗣、小向杏佳、金井昭教、國井大誓、坂井卓磨、貞富凌、王冰、下川卓志、中田健也、武村直紀、齊藤達哉、稲葉俊哉、椎名勇
- Organizer
  第60回日本放射線腫瘍学会生物部会学術大会
- Data Source
  KAKENHI-PROJECT-23K27550
[Presentation] 炎症誘発性プラットフォームを標的とする放射線防護剤の開発2023
- Author(s)
  森田明典、谷本大河、東優一、西山祐一、昌子紡己、村田貴嗣、小向杏佳、金井昭教、國井大誓、坂井卓磨、貞富凌、王冰、下川卓志、中田健也、武村直紀、齊藤達哉、稲葉俊哉、椎名勇
- Organizer
  第60回日本放射線腫瘍学会生物部会学術大会
- Data Source
  KAKENHI-PROJECT-21K07644
[Presentation] A novel immunomodulatory compound that prevents sub-total body irradiation-induced intestinal death2021
- Author(s)
  Taiga Tanimoto, Akinori Morita, Yuichi Nishiyama, Takatsugu Murata, Anjyu Sakai, Akinori Kanai, Yuichi Higashi, Taisei Kunii, Takuma Sakai, Ryo Sadatomi, Bing Wang, Takashi Shimokawa, Kenya Nakata, Naoki Takemura, Tatsuya Saitoh, Toshiya Inaba, Isamu Shiina
- Organizer
  The 64th Annual Meeting of the Japan Radiation Research Society
- Data Source
  KAKENHI-PROJECT-21K07644
[Presentation] 抗炎症作用を有する新規化合物の放射線防護剤としての活性評価2021
- Author(s)
  谷本大河、森田明典、西山祐一、村田貴嗣、酒井杏樹、金井昭教、東優一、越智進太郎、國井大誓、坂井卓磨、貞富凌、王冰、下川卓志、中田健也、齊藤達哉、稲葉俊哉、椎名勇
- Organizer
  第58回日本放射線腫瘍学会生物部会学術大会・第49回放射線による制癌シンポジウム
- Data Source
  KAKENHI-PROJECT-21K07644
[Presentation] 抗炎症作用を有する新規化合物の腸炎制御剤としての活性評価2021
- Author(s)
  東優一、森田明典、西山祐一、村田貴嗣、酒井杏樹、金井昭教、谷本大河、坂井卓磨、中田健也、武村直紀、齊藤達哉、稲葉俊哉、椎名勇
- Organizer
  第29回日本Cell Death学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07644
[Presentation] Effect of ionizing radiation on the development of early mouse embryos.2020
- Author(s)
  Akinori Kanai, Natsumi Shimizu, Akiko Nagamachi, Hidehiko Kawai, Toshiya Inaba
- Organizer
  第63回放射線影響学会
- Data Source
  KAKENHI-PROJECT-18K18196
[Presentation] Internalization speed of surface cytokine receptors is critical for hematopoietic cell growth. サイトカイン受容体取込み速度が造血細胞の競合に与える影響：モノソミー７を有するMDSの発症機序2020
- Author(s)
  Toshiya Inaba, Akiko Nagamachi, Akinori Kanai, Jiro Kikuchi, Yusuke Furukawa.
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-18H02838
[Presentation] Abnormal receptor metabolism by Samd9/9L mutations is a cause of MIRAGE syndrome. Samd9/9L変異体による受容体取込み異常がMIRAGE症候群の骨髄・多臓器不全をもたらす2020
- Author(s)
  Akiko Nagamachi, Hirotaka Matsui, Akinori Kanai, Satoru Shinriki, Toshiya Inaba.
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-18H02838
[Presentation] Abnormal endocytosis due to a Samd9L mutation causes bone marrow/multi-organ failure in mice mimicking MIRAGE syndrome.モノソミー７を伴うMDSを多発するMIRAGE症候群モデルマウスに見られた受容体取込み異常2020
- Author(s)
  Akiko Nagamachi, Hirotaka Matsui, Akinori Kanai, Satoru Shinriki, and Toshiya Inaba.
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-18H02838
[Presentation] 低線量放射線が着床前期胚に与える影響の解析2019
- Author(s)
  金井昭教, 清水なつみ, 長町安希子, 河合秀彦, 稲葉俊哉
- Organizer
  第42回分子生物学会
- Data Source
  KAKENHI-PROJECT-18K18196
[Presentation] Effect of ionizing radiation on the development of early mouse embryos2019
- Author(s)
  Akinori Kanai, Natsumi Shimizu, Akiko Nagamachi, Hidehiko Kawai, Toshiya Inaba
- Organizer
  第62回放射線影響学会
- Data Source
  KAKENHI-PROJECT-18K18196
[Presentation] 8;21転座急性骨髄性白血病におけるエピゲノム調節因子の役割2019
- Author(s)
  上田　健、金井昭教、古室暁義、天野恭志、岡田　斉
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08679
[Presentation] The role of endosomal proteins, Samd9 and Samd9L, in hematopoiesis and myeloid diseases carrying monosomy 7.2019
- Author(s)
  Akiko Nagamachi, Hirotaka Matsui, Satoru Shinriki, Akinori Kanai, Toshiya Inaba
- Organizer
  日本癌学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02838
[Presentation] Regulation of receptor internalization by Samd9/Samd9L and their mutants2019
- Author(s)
  Akiko Nagamachi, Hirotaka Matsui, Satoru Shinriki, Akinori Kanai, Toshiya Inaba
- Organizer
  日本血液学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02838
[Presentation] 次世代シーケンサを用いた低線量放射線影響研究2018
- Author(s)
  金井昭教
- Organizer
  日本放射線影響学会第61回大会
- Data Source
  KAKENHI-PROJECT-18K18196
[Presentation] 急性骨髄性白血病におけるヒストン脱メチル化酵素KDM4Bの役割2018
- Author(s)
  上田　健、金井昭教、太田一成、古室暁義、天野恭志、岡　尚宏、岡田　斉
- Organizer
  第80回日本血液学会
- Data Source
  KAKENHI-PROJECT-17K08679
[Presentation] ヒストン脱メチル化酵素KDM4Bの急性骨髄性白血病における役割2018
- Author(s)
  上田　健、金井昭教、太田一成、古室暁義、天野恭志、岡田　斉
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08679
[Presentation] Target genes of DNA demethylating agents for improving anemia of MDS2018
- Author(s)
  Akinori Kanai
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K18196
[Presentation] Target genes of DNA demethylating agents for improving anemia of MDS2018
- Author(s)
  Akinori Kanai
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K18196
[Presentation] 8;21染色体転座白血病において高発現するヒストン脱メチル化酵素の機能的意義2017
- Author(s)
  上田健、金井昭教、太田一成、古室暁義、岡田　斉
- Organizer
  第40回日本分子生物学会、第90回日本生化学会
- Data Source
  KAKENHI-PROJECT-17K08679
[Presentation] UTX plays essential roles in hematopoietic stem cell by regulating aging-associated genes2017
- Author(s)
  世良康如、上田健、中田雄一郎、池田健一郎、山崎憲政、小田秀明、長町安希子、金井昭教、須田年生、田久保圭誉、稲葉俊哉、本田浩章
- Organizer
  第79回日本血液学会
- Data Source
  KAKENHI-PROJECT-17K08679
[Presentation] Analysis of radiation induced mutations using next generation sequencer.2017
- Author(s)
  Akinori Kanai, Akiko Nagamachi, Hidehiko Kawai, Hirotaka Matsui, Kenji Kamiya, Toshiya Inaba
- Organizer
  放射線災害・医科学研究拠点第 1 回国際シンポジウム
- Place of Presentation
  広島市広島大学
- Year and Date
  2017-02-21
- Data Source
  KAKENHI-PROJECT-15K16125
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析2016
- Author(s)
  金井昭教、長町安希子、河合秀彦、松井啓隆、神谷研二、稲葉俊哉
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  横浜市パシフィコ横浜広島市
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K16125
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析2016
- Author(s)
  金井昭教、長町安希子、河合秀彦、松井啓隆、神谷研二、稲葉俊哉
- Organizer
  日本放射線影響学会第59回大会
- Place of Presentation
  JMSアステールプラザ
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-15K16125
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析2015
- Author(s)
  金井昭教、長町安希子、河合秀彦、松井啓隆、神谷研二、稲葉俊哉
- Organizer
  平成27年度広島大学・長崎大学連携研究カンファランス
- Place of Presentation
  広島大学
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PROJECT-15K16125
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析2015
- Author(s)
  金井昭教、長町安希子、河合秀彦、松井啓隆、神谷研二、稲葉俊哉
- Organizer
  第４０回中国地区放射線影響研究会
- Place of Presentation
  広島大学
- Year and Date
  2015-07-17
- Data Source
  KAKENHI-PROJECT-15K16125
[Presentation] Low Miki expression in myelodysplastic syndromes results in polynuclear cell formation through decondensation of chromosomes in prolonged prometaphase.2015
- Author(s)
  Nagamachi A., Ozaki Y., Matsui H., Kanai A., Inaba T.
- Organizer
  The 57th American Society of Hematology Annual Meeting
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-12-06
- Data Source
  KAKENHI-PROJECT-15H04857
[Presentation] eEF1A2 is a target gene of DNA demethylating agents for improving anemia of MDS2015
- Author(s)
  Nagamachi A., Matsui H., Kanai A., Inaba T.
- Organizer
  The 77th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  金沢
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-15H04857
[Presentation] Analysis of radiation induced mutations using next generation sequencer.2015
- Author(s)
  Kanai, A.,Nagamachi A.,Kawai H.,Matsui H.,Kamiya K., Inaba T.
- Organizer
  ICRR
- Place of Presentation
  京都
- Year and Date
  2015-05-25
- Data Source
  KAKENHI-PROJECT-15H04857
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析2015
- Author(s)
  金井昭教、長町安希子、河合秀彦、松井啓隆、神谷研二、稲葉俊哉
- Organizer
  NGS現場の会第四回研究会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2015-07-01
- Data Source
  KAKENHI-PROJECT-15K16125
[Presentation] Analysis of radiation induced mutations using next generation sequencer.2015
- Author(s)
  Akinori Kanai, Akiko Nagamachi, Hidehiko Kawai, Hirotaka Matsui, Kamiya Kenji, Toshiya Inaba
- Organizer
  15th International Congress of Radiation Research (ICRR)
- Place of Presentation
  Kyoto International Conference Center
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16125
[Presentation] Determination of 5-hydroxymethylcytosine at single base resolution using next generation sequencer2014
- Author(s)
  Matsui H, Kanai A, Inaba T
- Organizer
  第43回国際実験血液学会(ISEH)年次集会
- Place of Presentation
  モントリオール(カナダ)
- Year and Date
  2014-08-23
- Data Source
  KAKENHI-PROJECT-24591397
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析2014
- Author(s)
  金井昭教、長町安希子、河合秀彦、松井啓隆、稲葉俊哉
- Organizer
  第55回原子爆弾後障害研究会
- Place of Presentation
  長崎市
- Year and Date
  2014-06-01
- Data Source
  KAKENHI-PROJECT-25550030
[Presentation] 大量データ解析を駆使した放射線影響解析手法の確立にむけて2014
- Author(s)
  松井啓隆, 河合秀彦, 金井昭教, 稲葉俊哉
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-01
- Data Source
  KAKENHI-PROJECT-24591397
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析2014
- Author(s)
  金井昭教、長町安希子、河合秀彦、松井啓隆、稲葉俊哉
- Organizer
  第39回中国地区放射線影響研究会
- Place of Presentation
  広島市
- Year and Date
  2014-07-18
- Data Source
  KAKENHI-PROJECT-25550030
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析2013
- Author(s)
  金井昭教
- Organizer
  放射線影響学会
- Place of Presentation
  クラウンパレス青森（青森県）
- Data Source
  KAKENHI-PROJECT-25550030
[Presentation] 造血器悪性腫瘍の発症・進展におけるエピゲノム異常の関与
- Author(s)
  松井啓隆, 金井昭教, 稲葉俊哉.
- Organizer
  日本放射線影響学会第56回大会
- Place of Presentation
  青森
- Data Source
  KAKENHI-PROJECT-24591397
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析
- Author(s)
  金井昭教、長町安希子、河合秀彦、松井啓隆、稲葉俊哉
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  鹿児島市
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-25550030
[Presentation] 次世代シーケンサーを用いた放射線誘発変異解析
- Author(s)
  金井昭教、長町安希子、河合秀彦、松井啓隆、稲葉俊哉
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜市
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25550030
[Presentation] Determination of 5-hydroxymethylcytosine at single base resolution using next generation sequencer.
- Author(s)
  Matsui H, Kanai A, Inaba T.
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591397
[Presentation] Analysis of radiation induced mutations using next generation sequencer
- Author(s)
  Akinori Kanai
- Organizer
  The 5th International Symposium of RIRBM
- Place of Presentation
  広島市
- Year and Date
  2015-03-02 – 2015-03-03
- Data Source
  KAKENHI-PROJECT-25550030
[Presentation] Determination of 5-hydroxymethylcytosine at single base resolution using next generation sequencer.
- Author(s)
  Matsui H, Kanai A, Inaba T.
- Organizer
  第75回日本血液学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24591397
[]

1. 長町安希子 (20585153)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
2. MATSUI HIROTAKA (60379849)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
3. Inaba Toshiya (60281292)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
4. UEDA Takeshi (60585149)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
5. 森田明典 (90334234)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. 横山明彦 (10506710)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. 川村猛 (70306835)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 笹谷めぐみ (80423052)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. KAWAI Hidehiko (30379846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. NISHIYAMA Yuichi (80730598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. 小俣洋介 (40968559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 土居主尚 (40455382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 志村勉 (40463799)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 青木伸 (00222472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 王冰 (10300914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 下川卓志 (20608137)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 椎名勇 (40246690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. HARADA Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
19. NAOE Yoshinori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. ICHI Ikuyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. HONDA Masahiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. ISHIKAWA Shu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. SHINRIKI Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. HARASHIMA Ai

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. OSHIMA Masanobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. Hara Eiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. UEDA Mitsuharu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. TAKUBO Keiyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. SANADA Masashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 原田浩徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
31. 本田善一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
32. 本田浩章

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
33. 北村俊雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
34. 谷本圭司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 大島拓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 山本靖彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 岩間厚志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 水口峰之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 谷時雄

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# of Collaborated Products: 1 results
40. 國本博義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 三澤清

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 望月大極

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 今井篤志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 古室暁義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 須田年生

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46. 長尾俊孝

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# of Collaborated Products: 1 results

KANAI AKINORI 金井 昭教

KANAI Akinori 金井 昭教

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Analysis of Trim43 in radiation-induced arrest of fertilized egg developmentPrincipal Investigator

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The effects of ionizing radiation on early development stage of the fertilized eggPrincipal Investigator

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Analysis of radiation induced mutation patterns and frequencies with whole genome sequencingPrincipal Investigator

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Analysis of radiation induced mutations using next generation sequencerPrincipal Investigator

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KANAI AKINORI 金井昭教

KANAI Akinori 金井昭教

[Journal Article] Successful Cord Blood Transplantation for Idiopathic CD4<sup>+</sup> Lymphocytopenia2021