MIYAKE Kunio 三宅邦夫

Researcher Number	60550712
Other IDs	https://orcid.org/0000-0001-9196-2229
Affiliation (Current)	2022: 山梨大学, 大学院総合研究部, 准教授
Affiliation (based on the past Project Information) *help	2017 – 2022: 山梨大学, 大学院総合研究部, 准教授 2017: 山梨大学, 大学院総合研究部, 講師 2015 – 2016: 山梨大学, 総合研究部, 講師 2014: 山梨大学, 総合研究部, 助教 2010 – 2013: University of Yamanashi, 医学工学総合研究部, 助教 2009 – 2010: University of Yamanashi, 大学院・医学工学総合研究部, 助教
Review Section/Research Field	Principal Investigator Pediatrics / Psychiatric science / Medium-sized Section 58:Society medicine, nursing, and related fields / Basic Section 58020:Hygiene and public health-related: including laboratory approach Except Principal Investigator Gastroenterology / Eating habits / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 56030:Urology-related / Medium-sized Section 58:Society medicine, nursing, and related fields
Keywords	Principal Investigator エピジェネティクス / DNAメチル化 / レット症候群 / 発達障害 / ヒストン修飾 / 精神疾患 / 抗精神病薬 / ヒストン脱アセチル化 / 自閉症 / MeCP2 … More / iPS細胞 / 出生コホート / DOHaD / エピゲノム / グリア細胞 / 抗炎症反応 / 神経科学 / 脳・神経 / 薬理学 / ストレス / エピジェネティック / 遺伝子発現 / シナプス / ＭＥＣＰ２ / 神経変性疾患 / 神経細胞死 / BDNF / ADHD / DNAヒドロキシメチル化 / 喫煙曝露 / 次世代シークエンサー / 胎児期 / 化学物質曝露 / DNA修飾 / 腸内細菌叢 / 遺伝子多型 / 腸内細菌 / メタゲノム … More Except Principal Investigator エピゲノム / miRNA / メチル化 / 膵液 / 膵癌 / 胆汁 / 血漿 / 胆道癌 / ERCP / マイクロRNA / BRD4 / 中鎖脂肪酸 / 代謝遺伝子 / 消化吸収遺伝子 / 生活習慣予防 / サルコペニア予防 / ライフステージ / 疾患ステージ / 中鎖脂肪 / 胎生期低栄養 / 成人期 / サルコペニア / エネルギー代謝 / 骨格筋 / 老齢現象 / トマトパウダー / エピジェネティックス / 代謝 / 低栄養モデル / 過栄養モデル / エピジェネティクス / ヒストンアセチル化 / 過栄養 / 低栄養 / 大脳皮質 / 排尿 / 光遺伝学 / 薬理遺伝学 / COVID-19 / 臨界期 / 発育・発達 / 健康危機 / DOHaD Less

膵癌高危険群における膵液中マイクロRNAとエピゲノム解析による早期診断法の確立
- Principal Investigator
  
  大坪公士郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kanazawa University
大脳における排尿関連細胞の選択的操作とそのプロファイルの探究
- Principal Investigator
  
  志村寛史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  University of Yamanashi
Exploring the Critical Period of Health Effects of the COVID-19 Disaster on Children - Creating a "Critical Period Causal Model" -
- Principal Investigator
  
  山縣然太朗
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  University of Yamanashi
Assessment of epigenome changes in fetal chemical exposurePrincipal Investigator
- Principal Investigator
  
  Miyake Kunio
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  University of Yamanashi
エピゲノム・メタゲノム交互作用解析による学童期の健康に与える影響の解明Principal Investigator
- Principal Investigator
  
  三宅邦夫
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  University of Yamanashi
Aberrant Methylation of Tumor Suppressive miRNAs in Patients With Pancreatic Cancer
- Principal Investigator
  
  Ohtsubo Koushiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University
Epigenetic amelioration of overfeeding-inducible functional declines in various organs by medium-chain fatty acids
- Principal Investigator
  
  MOCHIZUKI Kazuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits
- Research Institution
  University of Yamanashi
Development of epigenetic drugs for neurodevelopmental disordersPrincipal Investigator
- Principal Investigator
  
  MIYAKE Kunio
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi
Molecular mechanism of autism based on abnormalities of synaptic genes expression using iPS cells of Rett syndromePrincipal Investigator
- Principal Investigator
  
  MIYAKE Kunio
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi
Epigenetic mechanism in autism disorderPrincipal Investigator
- Principal Investigator
  
  MIYAKE Kunio
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi
Epigenetic mechanisms of antipsychotic drugs in glial cellsPrincipal Investigator
- Principal Investigator
  
  MIYAKE Kunio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Psychiatric science
- Research Institution
  University of Yamanashi

[Book] Chapter7: Epigenetics in autism and other neurodevelopmental diseases. In "Neurodegenerative Diseases"(Madae Curie Bioscience Databases)、ISBN 978-953-307-259-32011
- Author(s)
  Miyake K, HirasawaT, Koide T, KubotaT
- Publisher
  Landes Bioscience
- Data Source
  KAKENHI-PROJECT-23791156
[Book] 精神発達遅滞・自閉症の分子医学既知の遺伝子異常による発達障害・精神遅滞の分子医学 6. レット症候群の分子医学)2011
- Author(s)
  三宅邦夫, 久保田健夫
- Publisher
  医学のあゆみ
- Data Source
  KAKENHI-PROJECT-23791156
[Book] 精神疾患のエピジェネティクス:メチル化CpG結合蛋白(MeCP2)研究の最近の動向2011
- Author(s)
  三宅邦夫、久保田健夫
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-21890091
[Book] 精神疾患のエピジェネティクス:メチル化 CpG 結合蛋白(MeCP2)研究の最近の動向2011
- Author(s)
  三宅邦夫、久保田健夫
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-23791156
[Book] Epigenetics in autism and other neurodevelopmental diseases.Molecular Mechanism of Neurodegenerative diseases2011
- Author(s)
  Miyake K, Hirasawa T, Koide T, Kubota T
- Publisher
  Landes Bioscince/Springer(in press)
- Data Source
  KAKENHI-PROJECT-21890091
[Book] 遺伝子診療学-遺伝子診断の進歩とゲノム治療の展望2010
- Author(s)
  三宅邦夫
- Total Pages
  6
- Publisher
  日本臨床
- Data Source
  KAKENHI-PROJECT-21890091
[Book] エピジェネティクス.増刊号:遺伝子診療学-遺伝子診断の進歩とゲノム治療の展望2010
- Author(s)
  三宅邦夫、久保田健夫
- Publisher
  日本臨床
- Data Source
  KAKENHI-PROJECT-21890091
[Journal Article] All-cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan cohort2022
- Author(s)
  Yokomichi Hiroshi、Mochizuki Mie、Hirata Makoto、Nagai Akiko、Kojima Reiji、Horiuchi Sayaka、Ooka Tadao、Akiyama Yuka、Shinohara Ryoji、Miyake Kunio、Yamagata Zentaro、BioBank Japan Project
- Journal Title
  
  BMC Nutrition
  
  Volume: 12 Pages: 1425-1429
- DOI
  10.1111/jdi.13483
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K17376, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-19K10658, KAKENHI-PROJECT-21K10442
[Journal Article] Risk factors and long-term course of gastroesophageal reflux disease after peroral endoscopic myotomy: A large-scale multicenter cohort study in Japan2022
- Author(s)
  Yokomichi Hiroshi、Mochizuki Mie、Tsuchida Akiko、Kojima Reiji、Horiuchi Sayaka、Ooka Tadao、Akiyama Yuka、Miyake Kunio、Otawa Sanae、Shinohara Ryoji、Inadera Hidekuni、Yamagata Zentaro
- Journal Title
  
  Endoscopy
  
  Volume: 11 Pages: 1-6
- DOI
  10.1136/bmjopen-2020-047226
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-19K10658, KAKENHI-PROJECT-21K10442, KAKENHI-PROJECT-18K17376
[Journal Article] Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL.2022
- Author(s)
  Akahane Koshi、Kimura Shunsuke、Miyake Kunio、Watanabe Atsushi、Kagami Keiko、Yoshimura Kentaro、Shinohara Tamao、Harama Daisuke、Kasai Shin、Goi Kumiko、Kawai Tomoko、Hata Kenichiro、Kiyokawa Nobutaka、Koh Katsuyoshi、他7名
- Journal Title
  
  Blood Adv
  
  Volume: 6 Pages: 212-224
- DOI
  10.1182/bloodadvances.2021004271
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07728, KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-21K19405
[Journal Article] High Incidence of Atopic Dermatitis among Children Whose Fathers Work in Primary Industry: The Japan Environment and Children’s Study (JECS)2022
- Author(s)
  Yokomichi Hiroshi、Mochizuki Mie、Kojima Reiji、Horiuchi Sayaka、Ooka Tadao、Akiyama Yuka、Miyake Kunio、Kushima Megumi、Otawa Sanae、Shinohara Ryoji、Yamagata Zentaro、on behalf of the Japan Environment and Children’s Study Group
- Journal Title
  
  International Journal of Environmental Research and Public Health
  
  Volume: 19 Pages: 1761-1761
- DOI
  10.3390/ijerph19031761
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-19K10658, KAKENHI-PROJECT-21K10442
[Journal Article] Mother’s iodine exposure and infants’ hypothyroidism: the Japan Environment and Children’s Study (JECS)2022
- Author(s)
  Yokomichi Hiroshi、Mochizuki Mie、Kojima Reiji、Horiuchi Sayaka、Ooka Tadao、Akiyama Yuka、Miyake Kunio、Kushima Megumi、Otawa Sanae、Shinohara Ryoji、Yamagata Zentaro
- Journal Title
  
  Endocrine Journal
  
  Volume: 69 Issue: 1 Pages: 9-21
- DOI
  10.1507/endocrj.ej21-0168
  10.1507/endocrj.EJ21-0168
- NAID
  130008145295
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-19K10658, KAKENHI-PROJECT-21K10442, KAKENHI-PROJECT-18K17376
[Journal Article] Automatic discrimination of Yamamoto-Kohama classification by machine learning approach for invasive pattern of oral squamous cell carcinoma using digital microscopic images: a retrospective study2022
- Author(s)
  Ooka Tadao、Horiuchi Sayaka、Shinohara Ryoji、Kojima Reiji、Akiyama Yuka、Miyake Kunio、Otawa Sanae、Yokomichi Hiroshi、Yamagata Zentaro、on behalf of the Japan Environment and Children’s Study Group
- Journal Title
  
  Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
  
  Volume: 18 Pages: 11748-11748
- DOI
  10.3390/ijerph182211748
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-18K17376
[Journal Article] Elective cesarean delivery at term and its effects on respiratory distress at birth in Japan: The Japan Environment and Children's Study2021
- Author(s)
  Horiuchi Sayaka、Sakamoto Haruka、Abe Sarah K.、Shinohara Ryoji、Kushima Megumi、Otawa Sanae、Yui Hideki、Akiyama Yuka、Ooka Tadao、Kojima Reiji、Yokomichi Hiroshi、Miyake Kunio、Mizutani Takashi、Yamagata Zentaro
- Journal Title
  
  Health Science Reports
  
  Volume: 16
- DOI
  10.1371/journal.pone.0261121
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-18K17376
[Journal Article] Epigenetic Modification of Death Receptor Genes for TRAIL and TRAIL Resistance in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia2021
- Author(s)
  Watanabe Atsushi、Miyake Kunio、Akahane Koshi、Goi Kumiko、Kagami Keiko、Yagita Hideo、Inukai Takeshi
- Journal Title
  
  Genes
  
  Volume: 12 Pages: 864-864
- DOI
  10.3390/genes12060864
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-20H03928
[Journal Article] Effect of prenatal exposure to phthalates on epigenome-wide DNA methylations in cord blood and implications for fetal growth: The Hokkaido Study on Environment and Children's Health2021
- Author(s)
  Miura Ryu、Ikeda-Araki Atsuko、Ishihara Toru、Miyake Kunio、Miyashita Chihiro、Nakajima Tamie、Kobayashi Sumitaka、Ishizuka Mayumi、Kubota Takeo、Kishi Reiko
- Journal Title
  
  Science of The Total Environment
  
  Volume: 783 Pages: 147035-147035
- DOI
  10.1016/j.scitotenv.2021.147035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10636, KAKENHI-PROJECT-20K21707, KAKENHI-PUBLICLY-21H05332, KAKENHI-PROJECT-19H01071, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-18K17832, KAKENHI-PROJECT-21K17546
[Journal Article] Random forest approach for determining risk prediction and predictive factors of type 2 diabetes: large-scale health check-up data in Japan2021
- Author(s)
  Uchinuma Hiroyuki、Tsuchiya Kyoichiro、Sekine Tetsuo、Horiuchi Sayaka、Kushima Megumi、Otawa Sanae、Yokomichi Hiroshi、Miyake Kunio、Akiyama Yuka、Ooka Tadao、Kojima Reiji、Shinohara Ryoji、Hirata Shuji、Yamagata Zentaro; Japan Environment and Children’s Study Group
- Journal Title
  
  BMJ Nutrition, Prevention & Health
  
  Volume: 45 Pages: 140-148
- DOI
  10.1038/s41366-021-00947-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-18K17376
[Journal Article] LPCAT2 Methylation, a Novel Biomarker for the Severity of Cedar Pollen Allergic Rhinitis in Japan2021
- Author(s)
  Watanabe H, Miyake K, Matsuoka T, Kojima R, Sakurai D, Masuyama K, Yamagata Z.
- Journal Title
  
  American Journal of Rhinology & Allergy
  
  Volume: - Pages: 631-639
- DOI
  10.1177/1945892420983646
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-20K18275
[Journal Article] Frequency and clinical characteristics of special types of achalasia in Japan: A large‐scale, multicenter database study2021
- Author(s)
  Kojima Reiji、Shinohara Ryoji、Horiuchi Sayaka、Otawa Sanae、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Miyake Kunio、Yamagata Zentaro
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 201 Pages: 111530-111530
- DOI
  10.1016/j.envres.2021.111530
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-18K17376
[Journal Article] Factors of parental COVID-19 vaccine hesitancy: A cross sectional study in Japan2021
- Author(s)
  Kojima Reiji、Shinohara Ryoji、Kushima Megumi、Horiuchi Sayaka、Otawa Sanae、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Miyake Kunio、Yamagata Zentaro、the Japan Environment and Children’s Study Group
- Journal Title
  
  PLOS ONE
  
  Volume: 183 Pages: 201-209
- DOI
  10.1159/000519153
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-18K17376
[Journal Article] Association between preterm birth and maternal allergy considering IgE level2021
- Author(s)
  Kojima Reiji、Yokomichi Hiroshi、Akiyama Yuka、Ooka Tadao、Miyake Kunio、Horiuchi Sayaka、Shinohara Ryoji、Yamagata Zentaro、Japan Environment, Children's Study Group
- Journal Title
  
  Pediatrics International
  
  Volume: 63 Pages: 1026-1032
- DOI
  10.1111/ped.14635
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K17376, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-20K21707
[Journal Article] Screening of frequent variants associated with congenital hypothyroidism: a comparison with next generation sequencing2021
- Author(s)
  Watanabe Daisuke、Yagasaki Hideaki、Narusawa Hiromune、Saito Tomohiro、Mitsui Yumiko、Miyake Kunio、Ohta Masanori、Inukai Takeshi
- Journal Title
  
  Endocrine Journal
  
  Volume: 68 Issue: 12 Pages: 1411-1419
- DOI
  10.1507/endocrj.ej21-0353
  10.1507/endocrj.EJ21-0353
- NAID
  130008136503
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-20K08154
[Journal Article] DNA methylation of GFI1 as a mediator of the association between prenatal smoking exposure and ADHD symptoms at 6?years: the Hokkaido Study on Environment and Children’s Health2021
- Author(s)
  Miyake Kunio、Miyashita Chihiro、Ikeda-Araki Atsuko、Miura Ryu、Itoh Sachiko、Yamazaki Keiko、Kobayashi Sumitaka、Masuda Hideyuki、Ooka Tadao、Yamagata Zentaro、Kishi Reiko
- Journal Title
  
  Clinical Epigenetics
  
  Volume: 13 Pages: 74-74
- DOI
  10.1186/s13148-021-01063-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10636, KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-19H01071, KAKENHI-PROJECT-20H03928
[Journal Article] Per‐oral endoscopic myotomy in patients with antithrombotic agents: A large‐scale multicenter study in Japan2021
- Author(s)
  Horiuchi Sayaka、Shinohara Ryoji、Otawa Sanae、Kushima Megumi、Akiyama Yuka、Ooka Tadao、Kojima Reiji、Yokomichi Hiroshi、Miyake Kunio、Hirai Hiroyuki、Hashimoto Koichi、Shimabukuro Michio、Yamagata Zentaro、Japan Environment and Children’s Study Group
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 18 Pages: 12506-12506
- DOI
  10.3390/ijerph182312506
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-18K17376
[Journal Article] Effectiveness of influenza vaccination in infants and toddlers with and without prior infection history: The Japan Environment and Children's Study2021
- Author(s)
  Yokomichi Hiroshi、Kojima Reiji、Horiuchi Sayaka、Ooka Tadao、Akiyama Yuka、Miyake Kunio、Mochizuki Mie、Otawa Sanae、Shinohara Ryoji、Yamagata Zentaro
- Journal Title
  
  Vaccine
  
  Volume: 39 Pages: 1800-1804
- DOI
  10.1016/j.vaccine.2021.02.044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K17376, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-19K10658
[Journal Article] Impact of the COVID‐19 pandemic on high‐resolution manometry and peroral endoscopic myotomy for esophageal motility disorder in Japan2021
- Author(s)
  Horiuchi Sayaka、Shinohara Ryoji、Otawa Sanae、Kushima Megumi、Akiyama Yuka、Ooka Tadao、Kojima Reiji、Yokomichi Hiroshi、Miyake Kunio、Yamagata Zentaro、The Japan Environment and Children's Study Group
- Journal Title
  
  Digestive Endoscopy
  
  Volume: 4
- DOI
  10.1002/hsr2.421
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-18K17376
[Journal Article] Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL.2020
- Author(s)
  Atsushi Watanabe, Kunio Miyake, Jessica Nordlund, Ann-Christine Syvanen, Louise van der Weyden, Hiroaki Honda, Norimasa Yamasaki, Akiko Nagamachi, Toshiya Inaba, Tomokatsu Ikawa, Kevin Y Urayama, Nobutaka Kiyokawa, Akira Ohara, Shunsuke Kimura, Yasuo Kubota, Junko Takita, Hiroaki Goto, Kimiyoshi Sakaguchi, et al.
- Journal Title
  
  Blood
  
  Volume: 136 Pages: 2319-2333
- DOI
  10.1182/blood.2019004090
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08318, KAKENHI-PROJECT-19K22546, KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-19KK0222, KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-18K08357, KAKENHI-PROJECT-20H00528
[Journal Article] Assessment of MGMT methylation status using high-performance liquid chromatography in newly diagnosed glioblastoma.2020
- Author(s)
  Hanihara M, Miyake K, Watanabe A, Yamada Y, Oishi N, Kawataki T, Inukai T, Kondo T, Kinouchi H.
- Journal Title
  
  Clinical Epigenetics
  
  Volume: 12(1) Pages: 174-174
- DOI
  10.1186/s13148-020-00968-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21707, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-20H03928, KAKENHI-PROJECT-19K16554
[Journal Article] Aberrant methylation of tumor suppressive miRNAs in bile from patients with pancreaticobiliary diseases.2019
- Author(s)
  Ohtsubo K, Miyake K, Arai S, et al.
- Journal Title
  
  Anticancer Res
  
  Volume: 39 Pages: 5449-5459
- DOI
  10.21873/anticanres.13738
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09456
[Journal Article] An epigenome-wide study of cord blood DNA methylations in relation to prenatal perfluoroalkyl substance exposure: The Hokkaido study2018
- Author(s)
  Miura Ryu、Araki Atsuko、Miyashita Chihiro、Kobayashi Sumitaka、Kobayashi Sachiko、Wang Shu-Li、Chen Chung-Hsing、Miyake Kunio、Ishizuka Mayumi、Iwasaki Yusuke、Ito Yoichi M.、Kubota Takeo、Kishi Reiko
- Journal Title
  
  Environment International
  
  Volume: 115 Pages: 21-28
- DOI
  10.1016/j.envint.2018.03.004
- NAID
  120006847752
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19245, KAKENHI-PROJECT-15K09592, KAKENHI-PROJECT-15K15220, KAKENHI-PROJECT-16K15352, KAKENHI-PROJECT-18K10022
[Journal Article] Clofarabine exerts antileukemic activity against cytarabine-resistant B-cell precursor acute lymphoblastic leukemia with low deoxycytidine kinase expression2018
- Author(s)
  Huang M、Inukai T、Miyake K、Tanaka Y、Kagami K、Abe M、Goto H、Minegishi M、Iwamoto S、Sugihara E、Watanabe A、Somazu S、Shinohara T、Oshiro H、Akahane K、Goi K、Sugita K
- Journal Title
  
  Cancer Medicine
  
  Volume: 印刷中 Pages: 1297-1316
- DOI
  10.1002/cam4.1323
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06840, KAKENHI-PROJECT-15K09592, KAKENHI-PROJECT-18K07224
[Journal Article] Differential X Chromosome Inactivation Patterns during the Propagation of Human Induced Pluripotent Stem Cells2017
- Author(s)
  Andoh-Noda T, Akamatsu W, Miyake K, Kobayashi T, Ohyama M, Kurosawa H, Kubota T, Okano H.
- Journal Title
  
  Keio J. Med.
  
  Volume: 66(1) Issue: 1 Pages: 1-8
- DOI
  10.2302/kjm.2016-0015-oa
  10.2302/kjm.2016-0015-OA
- NAID
  130007314625
- ISSN
  0022-9717, 1880-1293
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09592
[Journal Article] Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny.2017
- Author(s)
  Furuse T, Miyake K, Kohda T, Kaneda H, Hirasawa T, Yamada I, Kushida T, Kashimura M, Kobayashi K, Ishino F, Kubota T, Wakana S.
- Journal Title
  
  Genes Nutr
  
  Volume: 12 Pages: 1-1
- DOI
  10.1186/s12263-016-0550-2
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26250024, KAKENHI-PROJECT-26430098, KAKENHI-PROJECT-26461521, KAKENHI-PROJECT-15K09592, KAKENHI-PROJECT-26430087, KAKENHI-PUBLICLY-15H01468, KAKENHI-PROJECT-17K07498
[Journal Article] Lack of association between deletion polymorphism of BIM gene and in vitro drug sensitivity in B-cell precursor acute lymphoblastic leukemia.2017
- Author(s)
  Huang Meixian、Miyake Kunio、Kagami Keiko、Abe Masako、Shinohara Tamao、Watanabe Atsushi、Somazu Shinpei、Oshiro Hiroko、Goi Kumiko、Goto Hiroaki、Minegishi Masayoshi、Iwamoto Shotaro、Kiyokawa Nobutaka、Sugita Kanji、Inukai Takeshi
- Journal Title
  
  Leuk Res.
  
  Volume: 60 Pages: 24-30
- DOI
  10.1016/j.leukres.2017.06.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09592, KAKENHI-PROJECT-15K09645
[Journal Article] Pre-treatment with amitriptyline causes epigenetic up-regulation of neuroprotection-associated genes and has anti-apoptotic effects in mouse neuronal cells2017
- Author(s)
  Tran Nguyen Quoc Vuong、Nguyen An Nghia、Takabe Kyoko、Yamagata Zentaro、Miyake Kunio
- Journal Title
  
  Neurotoxicology and Teratology
  
  Volume: 62 Pages: 1-12
- DOI
  10.1016/j.ntt.2017.05.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09592
[Journal Article] Neurodevelopmental Disorders and Environmental Toxicants: Epigenetics as an Underlying Mechanism2017
- Author(s)
  Tran Nguyen Quoc Vuong、Miyake Kunio
- Journal Title
  
  International Journal of Genomics
  
  Volume: 2017 Pages: 1-23
- DOI
  10.1155/2017/7526592
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09592
[Journal Article] Modeling Rett Syndrome Using Human Induced Pluripotent Stem Cells.2016
- Author(s)
  Andoh-Noda T, Inouye MO, Miyake K, Kubota T, Okano H, Akamatsu W.
- Journal Title
  
  CNS Neurol Disord Drug Targets
  
  Volume: 15(5) Pages: 544-550
- Data Source
  KAKENHI-PROJECT-15K09592
[Journal Article] Rett症候群などの精神発達疾患2015
- Author(s)
  三宅邦夫、久保田健夫
- Journal Title
  
  医学のあゆみ
  
  Volume: 255(6) Pages: 667-672
- Data Source
  KAKENHI-PROJECT-15K09592
[Journal Article] Understanding the epigenetics of neurodevelopmental disorders and DOHaD2015
- Author(s)
  Kubota T, Miyake K, Hariya N, Mochizuki K
- Journal Title
  
  J Dev Orig Health Dis
  
  Volume: 1 Pages: 1-9
- Data Source
  KAKENHI-PROJECT-25860852
[Journal Article] Epigenomic-basis of Preemptive Medicine for Neurodevelopmental Disorders.2015
- Author(s)
  Kubota T, Miyake K, Hariya N, Mochizuki K
- Journal Title
  
  Curr Genomics
  
  Volume: 16（３） Pages: 175-182
- DOI
  10.2174/1389202916666150216221312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09592, KAKENHI-PROJECT-15K15388
[Journal Article] 発達障害とエピジェネティクス2015
- Author(s)
  三宅邦夫、久保田健夫
- Journal Title
  
  日本ストレス学会誌
  
  Volume: 30(1) Pages: 27-36
- Data Source
  KAKENHI-PROJECT-15K09592
[Journal Article] Molecular mechanism in Rett syndrome2015
- Author(s)
  Miyake K, Kubota T
- Journal Title
  
  Folia Pharmacol. Jpn.
  
  Volume: 145(4) Issue: 4 Pages: 178-182
- DOI
  10.1254/fpj.145.178
- NAID
  130005061558
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-25860852, KAKENHI-PROJECT-15K09592
[Journal Article] A female patient with incomplete hemophagocytic lymphohistiocytosis caused by a heterozygous XIAP mutation associated with non-random X-chromosome inactivation skewed towards the wild-type XIAP allele.2015
- Author(s)
  Yang X, Hoshino A, Taga T, Kunitsu T, Ikeda Y, Yasumi T, Yoshida K, Wada T, Miyake K, Kubota T, Okuno Y, Muramatsu H, Adachi Y, Miyano S, Ogawa S, Kojima S, Kanegane H
- Journal Title
  
  J Clin Immunol
  
  Volume: 35(3) Pages: 244-248
- DOI
  10.1007/s10875-015-0144-6
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860852, KAKENHI-PROJECT-15K09592, KAKENHI-PROJECT-15K09642, KAKENHI-PROJECT-26461570
[Journal Article] Putative PPAR Target Genes Express Highly in Skeletal Muscle of Insulin-Resistant MetS Model SHR/NDmc-cp Rats2015
- Author(s)
  Hariya N, Miyake K, Kubota T, Goda T, Mochizuki K
- Journal Title
  
  Nutr Sci Vitaminol (Tokyo)
  
  Volume: 61（１） Pages: 28-36
- NAID
  130005070830
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09592
[Journal Article] Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage.2015
- Author(s)
  Andoh-Noda T, Akamatsu W, Miyake K, Matsumoto T, Yamaguchi R, Sanosaka T, Okada Y, Kobayashi T, Ohyama M, Nakashima K, Kurosawa H, Kubota T, Okano H
- Journal Title
  
  Mol Brain.
  
  Volume: ８ Pages: 1-1
- DOI
  10.1186/s13041-015-0121-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09592, KAKENHI-PROJECT-25640038, KAKENHI-PUBLICLY-15H01568, KAKENHI-PROJECT-15H04278, KAKENHI-PROJECT-15K15388, KAKENHI-PLANNED-26117007
[Journal Article] Epigenetics as a basis for diagnosis of neurodevelopmental disorders: challenges and opportunities2014
- Author(s)
  Kubota T, Miyake K, Hariya M, Mochizuki K.
- Journal Title
  
  Expert Rev Mol Diagn
  
  Volume: 14 Pages: 685-697
- DOI
  10.1586/14737159.2014.925805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670473, KAKENHI-PROJECT-25860852, KAKENHI-PROJECT-26293245, KAKENHI-PROJECT-221S0002
[Journal Article] 神経疾患のエピゲノム―脳機能障害を理解する新しい指標2014
- Author(s)
  久保田　健夫, 平澤　孝枝, 三宅　邦夫
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 66(5) Pages: 591-7
- NAID
  40020089078
- Data Source
  KAKENHI-PROJECT-25860852
[Journal Article] Expressions of tight junction proteins Occludin and Claudin-1 are under the circadian control in the mouse large intestine: implications in intestinal permeability and susceptibility to colitis.2014
- Author(s)
  Kyoko OO, Kono H, Ishimaru K, Miyake K, Kubota T, Ogawa H, Okumura K, Shibata S, Nakao A
- Journal Title
  
  PLoS One
  
  Volume: 9(5)
- DOI
  10.1371/journal.pone.0098016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860852, KAKENHI-PROJECT-26293087
[Journal Article] The role of epigenetics in Rett sydrome.2013
- Author(s)
  Kubota T, Miyake K, Hirasawa T
- Journal Title
  
  Epigenomics
  
  Volume: 5 Pages: 583-592
- DOI
  10.2217/epi.13.54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240062, KAKENHI-PROJECT-25670473, KAKENHI-PROJECT-25860852
[Journal Article] Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-β.2013
- Author(s)
  Motizuki M, Isogaya K, Miyake K, Ikushima H, Kubota T, Miyazono K, Saitoh M, Miyazawa K.
- Journal Title
  
  J Biol Chem.
  
  Volume: 288 Pages: 18911-18922
- DOI
  10.1074/jbc.m113.480996
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22112002, KAKENHI-PROJECT-24390419, KAKENHI-PROJECT-25860852
[Journal Article] Comparison of genomic and epigenomic expression in monozygotic twins discordant for Rett syndrome.2013
- Author(s)
  Miyake K, Yang C, Minakuchi Y, Ohori K, Soutome M, Hirasawa T, Kazuki Y, Adachi N, Suzuki S, Itoh M, Goto Y, Andoh T, Kurosawa H, Akamatsu W, Oyama M, Okano H, Oshimura M, Sasaki M, Toyoda A, Kubota T
- Journal Title
  
  PLoS One
  
  Volume: 8
- DOI
  10.1371/journal.pone.0066729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240062, KAKENHI-PROJECT-23390272, KAKENHI-PROJECT-23591491, KAKENHI-PROJECT-25670473, KAKENHI-PROJECT-25860852
[Journal Article] Epigenetics in autism and other neurodevelopmental diseases2012
- Author(s)
  Miyake K, Hirasawa T, Koide T, Kubota T
- Journal Title
  
  Adv Exp Med Biol.
  
  Volume: 724 Pages: 91-98
- Data Source
  KAKENHI-PROJECT-23791156
[Journal Article] Epigenetics in autism and other neurodevelopmental diseases2012
- Author(s)
  Miyake K, Hirasawa T, Koide T, Kubota T.
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 724 Pages: 91-98
- DOI
  10.1007/978-1-4614-0653-2_7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591491, KAKENHI-PROJECT-23791156
[Journal Article] Epigenetic understanding of gene-environment interactions in psychiatric disorders: a new concept of clinical genetics2012
- Author(s)
  Kubota T, Miyake K, Hirasawa T.
- Journal Title
  
  Clin Epigenetics.
  
  Volume: 4 Pages: 1-1
- Data Source
  KAKENHI-PROJECT-23791156
[Journal Article] Epigenetic Mechanisms and Therapeutic Perspectives for Neurodevelopmental Disorders2012
- Author(s)
  Kubota,T, Hirasawa,T. and Miyake,K
- Journal Title
  
  Pharmaceuticals
  
  Volume: 5 Pages: 369-383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791156
[Journal Article] Epigenetic understanding of gene-environment interactions in psychiatric disorders: a new concept of clinical genetics. Clin2012
- Author(s)
  Kubota,T., Miyake,K. and Hirasawa, T
- Journal Title
  
  Epigenetics
  
  Volume: 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791156
[Journal Article] The protocadherins, PCDHB1 and PCDH7, are regulated by MeCP2 in neuronal cells and brain tissues: implication for pathogenesis of Rett syndrome2011
- Author(s)
  Miyake K
- Journal Title
  
  BMC neuroscience
  
  Volume: 12 Pages: 81-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791156
[Journal Article] The protocadherins, PCDHB1and PCDH7, are regulated by MeCP2 in neuronal cells and brain tissues: implication for pathogenesis of Rett syndrome2011
- Author(s)
  Miyake, K., Hirasawa, T., Soutome, M., Itoh, M., Goto, Y., et al
- Journal Title
  
  BMC Neurosci
  
  Volume: 12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791156
[Journal Article] Novel etiological and therapeutic strategies for neurodiseases : epigenetic understanding of gene-environment interactions.2010
- Author(s)
  Kubota T, Miyake K, Hirasawa T, Nagai K, Koide T.
- Journal Title
  
  J Pharmacol Sci 113
  
  Pages: 3-8
- NAID
  10027744756
- Data Source
  KAKENHI-PROJECT-21890091
[Patent] 胃がん細胞の増殖抑制剤、胃がんの腫瘍形成抑制剤、胃がんを治療するための医薬、及び薬効予測方法2021
- Inventor(s)
  犬飼　岳史、渡邊　敦、赤羽　弘資、三宅　邦夫
- Industrial Property Rights Holder
  国立大学法人山梨大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-116120
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K21707
[Patent] 胃がん細胞の増殖抑制剤、胃がんの腫瘍形成抑制剤、胃がんを治療するための医薬、及び薬効予測方法2021
- Inventor(s)
  犬飼　岳史、渡邊　敦、赤羽　弘資、三宅　邦夫
- Industrial Property Rights Holder
  国立大学法人山梨大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-116120
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20H03928
[Patent] インプリンティング疾患の診断に有効な染色体機能異常の検査方法2014
- Inventor(s)
  久保田健夫、三宅邦夫
- Industrial Property Rights Holder
  久保田健夫、三宅邦夫
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-165148
- Filing Date
  2014-08-14
- Data Source
  KAKENHI-PROJECT-25860852
[Patent] 幹細胞の品質管理方法2014
- Inventor(s)
  與谷卓也、山田有里子、砂村栄一郎、久保田健夫、三宅邦夫
- Industrial Property Rights Holder
  與谷卓也、山田有里子、砂村栄一郎、久保田健夫、三宅邦夫
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-213137
- Filing Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-25860852
[Presentation] STAT3活性化変異を有する節外性NK/T細胞リンパ腫・鼻型はCD30を高発現する2021
- Author(s)
  大石直輝，佐藤啓，川島一郎，瀬川高弘，三宅邦夫，望月邦夫，桐戸敬太，近藤哲夫
- Organizer
  第61回日本リンパ網内系学会総会
- Data Source
  KAKENHI-PROJECT-20K21707
[Presentation] ヒトiPS細胞を用いた発生初期からのタバコ煙曝露による神経細胞分化への影響2021
- Author(s)
  三宅邦夫
- Organizer
  日本環境変異原ゲノム学会第50回記念大会
- Data Source
  KAKENHI-PROJECT-20H03928
[Presentation] STAT3活性化変異を有する節外性NK/T細胞リンパ腫・鼻型はCD30を高発現する2021
- Author(s)
  大石直輝，佐藤啓，川島一郎，瀬川高弘，三宅邦夫，望月邦夫，桐戸敬太，近藤哲夫
- Organizer
  第61回日本リンパ網内系学会総会
- Data Source
  KAKENHI-PROJECT-20H03928
[Presentation] ヒトiPS細胞を用いた発生初期からのタバコ煙曝露による神経細胞分化への影響2021
- Author(s)
  三宅邦夫
- Organizer
  日本環境変異原ゲノム学会第50回記念大会
- Data Source
  KAKENHI-PROJECT-20K21707
[Presentation] 膠芽腫におけるMGMT遺伝子メチル化の新規解析法 -HPLC法-2020
- Author(s)
  埴原光人、川瀧智之、荻原雅和、三宅邦夫、渡邊敦、大石直輝、山田有理子、犬飼岳史、木内博之
- Organizer
  日本脳神経外科学会第79回学術集会
- Data Source
  KAKENHI-PROJECT-20H03928
[Presentation] 白血病細胞のASNS遺伝子のメチル化解析におけるHPLC法の有用性2020
- Author(s)
  渡邊敦, 三宅邦夫, 篠原珠緒, 原間大輔, 笠井慎, 村上寧, 赤羽弘資, 合井久美子,山田有理子, 砂村栄一郎, 與谷卓也, 犬飼岳史
- Organizer
  第123回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03928
[Presentation] 膠芽腫におけるMGMT遺伝子メチル化の新規解析法 -HPLC法-2020
- Author(s)
  埴原光人、川瀧智之、荻原雅和、三宅邦夫、渡邊敦、大石直輝、山田有理子、犬飼岳史、木内博之
- Organizer
  日本脳神経外科学会第79回学術集会
- Data Source
  KAKENHI-PROJECT-20K21707
[Presentation] 白血病細胞のASNS遺伝子のメチル化解析におけるHPLC法の有用性2020
- Author(s)
  渡邊敦, 三宅邦夫, 篠原珠緒, 原間大輔, 笠井慎, 村上寧, 赤羽弘資, 合井久美子,山田有理子, 砂村栄一郎, 與谷卓也, 犬飼岳史
- Organizer
  第123回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21707
[Presentation] 各種膵胆道疾患における胆汁中癌抑制型miRNAのメチル化に関する検討2019
- Author(s)
  大坪公士郎、山下　要、三宅邦夫など
- Organizer
  第105回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-17K09456
[Presentation] 胆汁中癌抑制型miRNAのメチル化解析による膵胆道疾患の良悪性鑑別に関する検討2019
- Author(s)
  大坪公士郎、三宅邦夫、矢野聖二
- Organizer
  第61回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-17K09456
[Presentation] Analyses of Aberrant Methylation of Tumor Suppressive miRNAs in Bile in Patients With Pancreaticobiliary Diseases.2019
- Author(s)
  Ohtsubo K, Miyake K, Arai S, et al.
- Organizer
  4.The 50th Anniversary Joint Meeting of American Pancreatic Association and Jappanese Pancreas Society.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09456
[Presentation] 胆汁を用いた膵胆道疾患における癌抑制型miRNAのメチル化異常に関する検討2017
- Author(s)
  大坪公士郎、山下要、三宅邦夫、矢野聖二
- Organizer
  第４８回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-15K09592
[Presentation] 抗精神病薬アミトリプチリンはエピジェネティクス機構を介して神経細胞死を抑制する.2017
- Author(s)
  三宅邦夫、Vuong Tran、Nghia Nguyen、高部京子、山縣然太朗
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15K09592
[Presentation] Amitriptyline causes epigenetic up-regulation of neuroprotection-associated genes and has anti-apoptotic effects in mouse neuronal cells2017
- Author(s)
  Vuong Nguyen Quoc Tran,　Nghia An Nguyen, Kyoko Takabe, Zentaro Yamagata, Kunio Miyake
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15K09592
[Presentation] 胆汁を用いた膵胆道疾患における癌抑制型miRNAのメチル化異常に関する検討2017
- Author(s)
  大坪公士郎、山下　要、三宅邦夫、矢野聖二
- Organizer
  第48回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-17K09456
[Presentation] 妊娠中の喫煙曝露における臍帯血を用いたDNAメチル化変化領域の同定2017
- Author(s)
  三宅邦夫、三浦りゅう、小林祥子、小林澄貴、宮下ちひろ、荒木敦子、山縣然太朗、岸玲子
- Organizer
  第４６回日本環境変異原学会
- Data Source
  KAKENHI-PROJECT-15K09592
[Presentation] Association of BIM gene silencing by hypermethylation with chemoresistance in BCP-ALL.2016
- Author(s)
  Meixian Huang, Takeshi Inukai, Kunio Miyake, Keiko Kagami, Masako Abe, Tamao Shinohara, Atsushi Watanabe, Shinpei Somazu, Hiroko Oshiro, Kumiko Goi, Kanji Sugita.
- Organizer
  第78回日本血液学会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K09592
[Presentation] Involvement of Allele-Specific Methylation of Asparagine Synthetase Gene is in Asparaginase Sensitivity of BCP-ALL2016
- Author(s)
  Atsushi Watanabe, Takeshi Inukai, Minori Tamai, Tamao Shinohara, Shinpei Somazu, Hiroko Oshiro, Koushi Akahane, Kumiko Goi, Kunio Miyake, Kevin Y Urayama, Kanji Sugita.
- Organizer
  58th American Society of Hematology Annual meating
- Place of Presentation
  San Diego(USA)
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09592
[Presentation] 次世代シーケンサーによるALL細胞のL-Asp感受性におけるASNS遺伝子のメチル化解析2016
- Author(s)
  渡邊敦、犬飼岳史、篠原珠緒、杣津晋平、大城浩子、廣瀬衣子、合井久美子、三宅邦夫、久保田健夫、杉田完爾.
- Organizer
  第119回日本小児科学会学術集会
- Place of Presentation
  ロイトン札幌(北海道・札幌市）
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-15K09592
[Presentation] One carbon metabolism 関連遺伝子欠損マウスを親に持つ野生型マウスの行動表現型解析2016
- Author(s)
  古瀬民生、幸田尚、三宅邦夫、串田知子、山田郁子、柏村実生、三浦郁生、金田秀貴、小林喜美男、石野史敏、若菜茂晴
- Organizer
  第３９回日本神経科学大会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15K09592
[Presentation] 健康度を最適化する成育環境と個体の干渉原理　脳発達過程におけるメチル化DNA結合タンパク質MeCP2による遺伝子発現調節機構2015
- Author(s)
  １３１．三宅邦夫、久保田健夫
- Organizer
  第３８回日本分子生物学会　第８８回日本生化学会合同大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K09592
[Presentation] The antidepressant drug amitriptyline up-regulates the neuroprotective Atf3 and Cox2 genes by changing histone modifications in mouse primary cultured neuronal cells.2015
- Author(s)
  Nguyen NA, Miyake K, Kubota T
- Organizer
  第３８回日本神経科学会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15K09592
[Presentation] 胎児期ビスフェノールA曝露影響に関する臍帯血DNA網羅的メチル化解析—北海道スタディ2015
- Author(s)
  小林祥子、三浦りゅう、川口章夫、宮下ちひろ、三宅邦夫、松村徹、山本潤、石塚真由美、荒木敦子、久保田健夫、岸玲子
- Organizer
  DOHaD研究会第４回学術集会
- Place of Presentation
  東京都品川区
- Year and Date
  2015-08-01
- Data Source
  KAKENHI-PROJECT-15K09592
[Presentation] DPP-4阻害薬アナグリプチンによる胆汁酸の生成・分泌促進作用とインスリン抵抗性の改善2015
- Author(s)
  針谷夏代、井上拓哉、三宅邦夫、久保田健夫、望月和樹.
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  山口県下関市
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K09592
[Presentation] 新規母体低栄養モデルマウス作出の試み2015
- Author(s)
  古瀬民生、幸田尚、三宅邦夫、平澤孝枝、串田知子、山田郁子、柏村実生、金田秀貴、小林喜美男、石野史敏、久保田健夫、若菜茂晴
- Organizer
  DOHaD研究会第４回学術集会
- Place of Presentation
  東京都品川区
- Year and Date
  2015-08-01
- Data Source
  KAKENHI-PROJECT-15K09592
[Presentation] アニオン交換HPLCカラムを用いた新規DNAメチル化解析法の検討2015
- Author(s)
  三宅邦夫, 武居美沙, 太平博暁, 山田有理子, 砂村栄一郎, 與谷卓也, 久保田健夫
- Organizer
  第9回日本エピジェネティクス研究会
- Place of Presentation
  東京都千代田区
- Year and Date
  2015-05-25
- Data Source
  KAKENHI-PROJECT-15K09592
[Presentation] Rett症候群における病態分子機構2014
- Author(s)
  三宅　邦夫
- Organizer
  日本薬理学会
- Place of Presentation
  仙台国際センター　（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-25860852
[Presentation] Epigenomic differences in monozygotic twins with Rett syndrome2013
- Author(s)
  三宅　邦夫
- Organizer
  日本エピジェネティクス研究会
- Place of Presentation
  奈良県新公会堂　(奈良県奈良市）
- Data Source
  KAKENHI-PROJECT-25860852
[Presentation] 重症度差異のある一卵性双生児レット症候群患者におけるエピゲノム比較2013
- Author(s)
  三宅　邦夫
- Organizer
  日本神経科学会
- Place of Presentation
  国立京都国際会館　（京都府京都市）
- Data Source
  KAKENHI-PROJECT-25860852
[Presentation] Corticosterone facilitates the synchronized calcium oscillation in hippocampal neurons2011
- Author(s)
  Hirasawa T, Endo A, Miyake K, Koizumi S, Kubota T
- Organizer
  23th Biennial Meeting,International Society for Neurochemistry jointly with the European Society for Neuroscience
- Place of Presentation
  Athens, Greece
- Data Source
  KAKENHI-PROJECT-23791156
[Presentation] Identification of MeCP2-target synaptic molecules associated with pathogenesis of Rett syndrome2011
- Author(s)
  Miyake K, Hirasawa T, Taira T, Kubota T
- Organizer
  23th Biennial Meeting,International Society for Neurochemistry jointly with the European Society for Neuroscience
- Place of Presentation
  Athens, Greece
- Data Source
  KAKENHI-PROJECT-23791156
[Presentation] レット症候群責任蛋白質MeCP2の新規標的遺伝子の探索2010
- Author(s)
  三宅邦夫
- Organizer
  第4回日本エピジェネティクス研究会
- Place of Presentation
  米子市文化ホール
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-21890091
[Presentation] レット症候群責任蛋白質MeCP2の新規標的シナプス関連分子の同定2010
- Author(s)
  三宅邦夫
- Organizer
  第33回日本分子生物学会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21890091
[Presentation] Change of neuronal gene expression by administration of various anti-depressant in primary neocortical neurons
- Author(s)
  N. A. Nguyen, K. Miyake, T. Kubota
- Organizer
  ASHG
- Place of Presentation
  San Diego　（USA)
- Year and Date
  2014-10-18 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-25860852
[Presentation] 発達障害とエピジェネティクス
- Author(s)
  三宅　邦夫
- Organizer
  日本ストレス学会学術総会　第30回記念大会
- Place of Presentation
  日本大学文理学部百周年記念館（世田谷区・東京）
- Year and Date
  2014-11-07 – 2014-11-08
- Invited
- Data Source
  KAKENHI-PROJECT-25860852
[Presentation] DNA のメチル化修飾を検出できるアニオン交換 HPLC カラムの臨床応用
- Author(s)
  22.武居美沙、三宅邦夫、山田有理子、與谷卓也、久保田健夫
- Organizer
  日本人類遺伝学会第５９回大会
- Place of Presentation
  タワーホール船堀　（江戸川区・東京）
- Year and Date
  2014-11-19 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-25860852
[Presentation] 変異体マウスを用いた翻訳伸長因子遺伝子欠損の血液学的影響
- Author(s)
  18.庄司陽平,久保田悠一,井上克枝,久保田健夫,三宅邦夫,葛西宏威,武川克志,手塚英夫.
- Organizer
  第60回日本実験動物学会総会
- Place of Presentation
  つくば国際会議場　(茨城県・つくば市）
- Year and Date
  2014-05-15 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-25860852
[Presentation] Clinical application of an anion exchange HPLC column that distinguishes DNA methylation status
- Author(s)
  K. Miyake, Y. Yamada, T. Yotani, T. Kubota
- Organizer
  ASHG
- Place of Presentation
  San Diego　（USA)
- Year and Date
  2014-10-18 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-25860852

1. Ohtsubo Koushiro (60361987)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. MOCHIZUKI Kazuki (80423838)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. 山下要 (80456425)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 山縣然太朗 (10210337)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
5. 三好規之 (70438191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 針谷夏代 (80732784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 幸田尚 (60211893)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 宮下ちひろ (70632389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 篠原亮次 (00633116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
10. 志村寛史 (70755842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 葛西宏威 (20324189)

# of Collaborated Projects: 1 results

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12. 武田正之 (80197318)

# of Collaborated Projects: 1 results

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13. 三井貴彦 (90421966)

# of Collaborated Projects: 1 results

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14. 瀬川高弘 (90425835)

# of Collaborated Projects: 1 results

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15. IKAWA Tomokatsu

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# of Collaborated Products: 1 results
16. AMEMIYA Sin

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# of Collaborated Products: 5 results
17. NAKAJIMA Sonomi

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# of Collaborated Products: 1 results
18. ARAKI Atsuko

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# of Collaborated Products: 3 results
19. FURUSE Tamio

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# of Collaborated Products: 1 results
20. MIYAZAWA Keiji

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# of Collaborated Products: 1 results
21. YAGASAKI Hideaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. WADA Taizo

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# of Collaborated Products: 1 results
23. HOSHINO Akihiro

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# of Collaborated Products: 1 results
24. 坂口公祥

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# of Collaborated Products: 1 results
25. 本田善一郎

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# of Collaborated Products: 1 results
26. 本田浩章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 長町安希子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 稲葉俊哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 犬飼岳史

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
30. 合井久美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
31. 赤羽弘資

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
32. 渡邊敦

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
33. 篠原珠緒

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
34. 滝田順子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
35. 久保田健夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
36. 平澤孝枝

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
37. 横道洋司

# of Collaborated Projects: 0 results

# of Collaborated Products: 13 results
38. 大石直輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 岸玲子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
40. 小林澄貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
41. 三浦りゅう

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# of Collaborated Products: 3 results
42. 若菜茂晴

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# of Collaborated Products: 1 results
43. 小林慎

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# of Collaborated Products: 1 results
44. 石野史敏

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# of Collaborated Products: 1 results
45. 吉村健太郎

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# of Collaborated Products: 1 results
46. 原間大輔

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# of Collaborated Products: 1 results
47. 渡辺浩介

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48. 奥村康

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# of Collaborated Products: 1 results
49. 宮園浩平

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# of Collaborated Products: 1 results
50. 齋藤正夫

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# of Collaborated Products: 1 results
51. 黒澤尋

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# of Collaborated Products: 1 results
52. 岡野栄之

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# of Collaborated Products: 2 results
53. 豊田敦

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# of Collaborated Products: 1 results
54. 山崎圭子

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# of Collaborated Products: 1 results
55. 金兼弘和

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# of Collaborated Products: 1 results
56. 岡田洋平

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# of Collaborated Products: 1 results
57. 宮冬樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
58. 赤松和土

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
59. 杉原英志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIYAKE Kunio 三宅 邦夫

Research Projects

Research Products

Co-Researchers

膵癌高危険群における膵液中マイクロRNAとエピゲノム解析による早期診断法の確立

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大脳における排尿関連細胞の選択的操作とそのプロファイルの探究

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Exploring the Critical Period of Health Effects of the COVID-19 Disaster on Children - Creating a "Critical Period Causal Model" -

Principal Investigator

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Assessment of epigenome changes in fetal chemical exposurePrincipal Investigator

Principal Investigator

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エピゲノム・メタゲノム交互作用解析による学童期の健康に与える影響の解明Principal Investigator

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Aberrant Methylation of Tumor Suppressive miRNAs in Patients With Pancreatic Cancer

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Epigenetic amelioration of overfeeding-inducible functional declines in various organs by medium-chain fatty acids

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Development of epigenetic drugs for neurodevelopmental disordersPrincipal Investigator

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Molecular mechanism of autism based on abnormalities of synaptic genes expression using iPS cells of Rett syndromePrincipal Investigator

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Epigenetic mechanism in autism disorderPrincipal Investigator

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Epigenetic mechanisms of antipsychotic drugs in glial cellsPrincipal Investigator

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[Book] Chapter7: Epigenetics in autism and other neurodevelopmental diseases. In "Neurodegenerative Diseases"(Madae Curie Bioscience Databases)、ISBN 978-953-307-259-32011

Author(s)

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Data Source

[Book] 精神発達遅滞・自閉症の分子医学 既知の遺伝子異常による発達障害・精神遅滞の分子医学 6. レット症候群の分子医学)2011

Author(s)

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Data Source

[Book] 精神疾患のエピジェネティクス:メチル化CpG結合蛋白(MeCP2)研究の最近の動向2011

Author(s)

MIYAKE Kunio 三宅邦夫

[Book] 精神発達遅滞・自閉症の分子医学既知の遺伝子異常による発達障害・精神遅滞の分子医学 6. レット症候群の分子医学)2011