Sengoku Toru 仙石徹

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SENGOKU Toru 仙石徹

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Researcher Number	60576312
Other IDs	https://orcid.org/0000-0001-9461-8714
Affiliation (Current)	2024: 横浜市立大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 横浜市立大学, 医学部, 准教授 2018 – 2021: 横浜市立大学, 医学部, 講師 2015 – 2017: 国立研究開発法人理化学研究所, 横山構造生物学研究室, 研究員 2013 – 2014: 独立行政法人理化学研究所, 横山構造生物学研究室, 研究員 2011 – 2012: 独立行政法人理化学研究所, システム研究チーム, 研究員
Review Section/Research Field	Principal Investigator Biological Sciences / Transformative Research Areas, Section (III) / Molecular biology / Structural biochemistry Except Principal Investigator Basic Section 43020:Structural biochemistry-related / Transformative Research Areas, Section (III) / Science and Engineering / Basic Section 62010:Life, health and medical informatics-related / Chemical biology / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Keywords	Principal Investigator エピジェネティクス / X線結晶構造解析 / クライオ電子顕微鏡 / 分化 / ユビキチン化 / クライオ電顕 / 転写 / 転写因子 / 構造生物学 / がん … More / ヒストン / 分子動力学 / 多発性骨髄腫 / 翻訳後修飾 / 結晶構造解析 / 阻害剤開発 / 酵素 / スクリーニング / ケミカルバイオロジー … More Except Principal Investigator 転写因子 / 転写制御 / 基質特異性 / ペプチド創薬 / X線結晶構造解析 / 酵素反応機構 / プレニル基転移酵素 / 酵素基質特異性 / 遺伝子発現制御 / 分子間相互作用 / 転写 / 多因子間相互作用 / 遺伝子発現 / 転写ユニティー / コロナウィルス / コロナウイルス / 薬剤探索 / 擬天然物 / 特殊ペプチド / 分子シミュレーション / 天然変性蛋白質 / 翻訳後修飾 / 分子動力学法 / 天然変性領域 / 分子標的薬 / 医薬品探索 / 癌 / 創薬 / がん / 転写制御機構 / 定量解析 / エンハンソソーム / クライオ電子顕微鏡 / ヒストン修飾酵素 / ヌクレオソーム Less

ペプチド創薬に応用可能なペプチドプレニル基転移酵素群の構造生物学的解析
- Principal Investigator
  
  浜田恵輔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Yokohama City University
Structural elucidation of the multi-subunit interactions that establish the transcriptional unity mechanismPrincipal Investigator
- Principal Investigator
  
  仙石徹
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Yokohama City University
Elucidation of the mechanisms of transcriptional unity by understanding spatiotemporal multifactorial interactions
- Principal Investigator
  
  二村圭祐
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Osaka University
トリプトファンプレニル基転移酵素のペプチド基質認識と反応機構の構造学的解明
- Principal Investigator
  
  浜田恵輔
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Yokohama City University
Study of the phosphorylation latch mechanism for the transcriptional regulation via intrinsically disordered regions
- Principal Investigator
  
  笠原浩太
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Ritsumeikan University
Challenges to the remaining issues of therapeutically valuable pseudo-natural peptides and products
- Principal Investigator
  
  菅裕明
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Mechanisms that establish, maintain, and dysregulate histone methylation statesPrincipal Investigator
- Principal Investigator
  
  仙石徹
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Study of the mechanism of nucleosome-enhanceosome conversion
- Principal Investigator
  
  OGATA Kazuhiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Yokohama City University
Search for anti-leukemic drugs targeting the cancer-related transcription factor Runx1/CBFbeta
- Principal Investigator
  
  Ogata Kazuhiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical biology
- Research Institution
  Yokohama City University
Reaction mechanism and inhibitor development of a histone demethylasePrincipal Investigator
- Principal Investigator
  
  Sengoku Toru
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University
  Institute of Physical and Chemical Research
ヒストンメチル化酵素複合体の構造解析Principal Investigator
- Principal Investigator
  
  仙石徹
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Structural and functional analyses of a histone demethylase that regulates cell differentiationPrincipal Investigator
- Principal Investigator
  
  SENGOKU Toru
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The Institute of Physical and Chemical Research

All 2023 2022 2021 2020 2019 2018 2017 2016 2014 2013 2012 2011

All Journal Article Presentation

[Journal Article] Brain monoamine vesicular transport disease caused by homozygous SLC18A2 variants: A study in 42?affected individuals2023
- Author(s)
  Saida Ken、Maroofian Reza、Sengoku Toru、et al.
- Journal Title
  
  Genetics in Medicine
  
  Volume: 25 Issue: 1 Pages: 90-102
- DOI
  10.1016/j.gim.2022.09.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-21H05158, KAKENHI-PROJECT-20K07907, KAKENHI-PROJECT-20K08164, KAKENHI-PROJECT-20K17936, KAKENHI-PROJECT-23K24308
[Journal Article] Structure of the human Bre1 complex bound to the nucleosome2023
- Author(s)
  Onishi Shuhei、Uchiyama Kotone、Sato Ko、Okada Chikako、Kobayashi Shunsuke、Nishizawa Tomohiro、Nureki Osamu、Ogata Kazuhiro、Sengoku Toru
- Journal Title
  
  bioRxiv
  
  Volume: NA
- DOI
  10.1101/2023.03.31.535082
- Data Source
  KAKENHI-PLANNED-21H05161
[Journal Article] Structural basis of transcription regulation by CNC family transcription factor, Nrf22022
- Author(s)
  Sengoku Toru、Shiina Masaaki、Suzuki Kae、Hamada Keisuke、Sato Ko、Uchiyama Akiko、Kobayashi Shunsuke、Oguni Asako、Itaya Hayato、Kasahara Kota、Moriwaki Hirotomo、Watanabe Chiduru、Honma Teruki、Okada Chikako、Baba Shiho、Ohta Tsutomu、Motohashi Hozumi、Yamamoto Masayuki、Ogata Kazuhiro
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 50 Issue: 21 Pages: 12543-12557
- DOI
  10.1093/nar/gkac1102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06051, KAKENHI-PLANNED-21H05264, KAKENHI-ORGANIZER-21H05158, KAKENHI-PROJECT-21H04799, KAKENHI-PLANNED-21H05161
[Journal Article] LimF is a versatile prenyltransferase for histidine-C-geranylation on diverse non-natural substrates2022
- Author(s)
  Zhang Yuchen、Hamada Keisuke、Nguyen Dinh Thanh、Inoue Sumika、Satake Masayuki、Kobayashi Shunsuke、Okada Chikako、Ogata Kazuhiro、Okada Masahiro、Sengoku Toru、Goto Yuki、Suga Hiroaki
- Journal Title
  
  Nature Catalysis
  
  Volume: 5 Issue: 8 Pages: 682-693
- DOI
  10.1038/s41929-022-00822-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06051, KAKENHI-PROJECT-21K19056, KAKENHI-PROJECT-20H05618, KAKENHI-ORGANIZER-21H05158, KAKENHI-PROJECT-19H02842
[Journal Article] De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors2022
- Author(s)
  Vinogradov Alexander A.、Zhang Yue、Hamada Keisuke、Chang Jun Shi、Okada Chikako、Nishimura Hirotaka、Terasaka Naohiro、Goto Yuki、Ogata Kazuhiro、Sengoku Toru、Onaka Hiroyasu、Suga Hiroaki
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 144 Issue: 44 Pages: 20332-20341
- DOI
  10.1021/jacs.2c07937
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06051, KAKENHI-PROJECT-20H05618, KAKENHI-ORGANIZER-21H05158, KAKENHI-PROJECT-21H04712, KAKENHI-PROJECT-22KF0114
[Journal Article] Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD22021
- Author(s)
  Sato Ko、Kumar Amarjeet、Hamada Keisuke、Okada Chikako、Oguni Asako、Machiyama Ayumi、Sakuraba Shun、Nishizawa Tomohiro、Nureki Osamu、Kono Hidetoshi、Ogata Kazuhiro、Sengoku Toru
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 6605-6605
- DOI
  10.1038/s41467-021-26913-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05534, KAKENHI-PUBLICLY-20H05394, KAKENHI-ORGANIZER-21H05158, KAKENHI-PROJECT-20K08717
[Journal Article] An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human β-Factor XIIa in a Cyclotide Scaffold2021
- Author(s)
  Liu Wenyu、de Veer Simon J.、Huang Yen-Hua、Sengoku Toru、Okada Chikako、Ogata Kazuhiro、Zdenek Christina N.、Fry Bryan G.、Swedberg Joakim E.、Passioura Toby、Craik David J.、Suga Hiroaki
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 143 Issue: 44 Pages: 18481-18489
- DOI
  10.1021/jacs.1c07574
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-21H05158, KAKENHI-PROJECT-20J11284
[Journal Article] OTUD5 Variants Associated With X-Linked Intellectual Disability and Congenital Malformation2021
- Author(s)
  Saida K, Fukuda T, Scott DA, Sengoku T, Ogata K, Nicosia A, Hernandez-Garcia A, Lalani SR, Azamian MS, Streff H, Liu P, Dai H, Mizuguchi T, Miyatake S, Asahina M, Ogata T, Miyake N, Matsumoto N.
- Journal Title
  
  Front Cell Dev Biol.
  
  Volume: 9 Pages: 631428-631428
- DOI
  10.3389/fcell.2021.631428
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07907, KAKENHI-PROJECT-20K08164, KAKENHI-PROJECT-18K19305, KAKENHI-PROJECT-20H00539
[Journal Article] Phenotype?genotype correlations in patients with GNB1 gene variants, including the first three reported Japanese patients to exhibit spastic diplegia, dyskinetic quadriplegia, and infantile spasms2020
- Author(s)
  Endo Wakaba, et al., Matsumoto Naomichi, Haginoya Kazuhiro
- Journal Title
  
  Brain and Development
  
  Volume: 42 Issue: 2 Pages: 199-204
- DOI
  10.1016/j.braindev.2019.10.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01539, KAKENHI-PROJECT-17K10080, KAKENHI-PROJECT-20K08236, KAKENHI-PROJECT-18K19305
[Journal Article] Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic β-amino acids2020
- Author(s)
  Katoh Takayuki、Sengoku Toru、Hirata Kunio、Ogata Kazuhiro、Suga Hiroaki
- Journal Title
  
  Nature Chemistry
  
  Volume: 12 Issue: 11 Pages: 1081-1088
- DOI
  10.1038/s41557-020-0525-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H05618, KAKENHI-PROJECT-18H02080, KAKENHI-PROJECT-18K19305, KAKENHI-PLANNED-16H06444
[Journal Article] Development and Structural Evaluation of N‐Alkylated trans‐2‐Phenylcyclopropylamine‐Based LSD1 Inhibitors2020
- Author(s)
  Niwa Hideaki、Sato Shin、Handa Noriko、Sengoku Toru、Umehara Takashi、Yokoyama Shigeyuki
- Journal Title
  
  ChemMedChem
  
  Volume: 15 Issue: 9 Pages: 787-793
- DOI
  10.1002/cmdc.202000014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19305
[Journal Article] Structural basis of the regulation of normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD22020
- Author(s)
  Sato Ko、Kumar Amarjeet、Hamada Keisuke、Okada Chikako、Oguni Asako、Machiyama Ayumi、Sakuraba Shun、Nishizawa Tomohiro、Nureki Osamu、Kono Hidetoshi、Ogata Kazuhiro、Sengoku Toru
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2020.12.05.413278
- Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05394
[Journal Article] A novel PAK1 variant causative of neurodevelopmental disorder with postnatal macrocephaly2020
- Author(s)
  Ohori Sachiko、Mitsuhashi Satomi、Ben-Haim Revital、Heyman Eli、Sengoku Toru、Ogata Kazuhiro、Matsumoto Naomichi
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 65 Issue: 5 Pages: 481-485
- DOI
  10.1038/s10038-020-0728-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19305
[Journal Article] The recurrent postzygotic pathogenic variant p.Glu47Lys in RHOA causes a novel recognizable neuroectodermal phenotype2019
- Author(s)
  Yigit Gokhan、Saida Ken、DeMarzo Danielle、Miyake Noriko、Fujita Atsushi、Yang Tan Tiong、White Susan M.、Wadley Alexandrea、Toliat Mohammad R.、Motameny Susanne、Franitza Marek、Stutterd Chloe A.、Chong Pin F.、Kira Ryutaro、et al.
- Journal Title
  
  Human Mutation
  
  Volume: 41 Issue: 3 Pages: 591-599
- DOI
  10.1002/humu.23964
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10613, KAKENHI-PROJECT-18K19305, KAKENHI-PROJECT-17H01539, KAKENHI-PROJECT-19H03621
[Journal Article] Structural basis of protein arginine rhamnosylation by glycosyltransferase EarP2018
- Author(s)
  Sengoku Toru、Suzuki Takehiro、Dohmae Naoshi、Watanabe Chiduru、Honma Teruki、Hikida Yasushi、Yamaguchi Yoshiki、Takahashi Hideyuki、Yokoyama Shigeyuki、Yanagisawa Tatsuo
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 14 Issue: 4 Pages: 368-374
- DOI
  10.1038/s41589-018-0002-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K21626, KAKENHI-PROJECT-15K08485, KAKENHI-PROJECT-18K19305, KAKENHI-PROJECT-16H03293, KAKENHI-PROJECT-16K05859, KAKENHI-PROJECT-16H04758
[Journal Article] Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity2018
- Author(s)
  Nishio Kosuke、Belle Roman、Katoh Takayuki、Kawamura Akane、Sengoku Toru、Hanada Kazuharu、Ohsawa Noboru、Shirouzu Mikako、Yokoyama Shigeyuki、Suga Hiroaki
- Journal Title
  
  ChemBioChem
  
  Volume: 19 Issue: 9 Pages: 979-985
- DOI
  10.1002/cbic.201800047
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19305, KAKENHI-PROJECT-26220204, KAKENHI-PROJECT-16H03293
[Journal Article] UTX and UTY Demonstrate Histone Demethylase-Independent Function in Mouse Embryonic Development2012
- Author(s)
  Karl B. Shpargel, Toru Sengoku, Shigeyuki Yokoyama, Terry Magnuson
- Journal Title
  
  PLOS genetics
  
  Volume: 8 Issue: 9 Pages: e1002964-e1002964
- DOI
  10.1371/journal.pgen.1002964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770131
[Journal Article] Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A2011
- Author(s)
  Sengoku T, Yokoyama S
- Journal Title
  
  Genes Dev
  
  Volume: 25(21) Issue: 21 Pages: 2266-77
- DOI
  10.1101/gad.172296.111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770131
[Presentation] LECのコンポーネントZC3H8による転写終結制御機構の解明2022
- Author(s)
  鬼澤理紗, 野口慶介, 仙石徹, 緒方一博, 鈴木秀文, 高橋秀尚
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-ORGANIZER-21H05158
[Presentation] ヌクレオソーム上H2Bモノユビキチン化の構造基盤2022
- Author(s)
  大西　修平、内山　琴音、佐藤　光、岡田　千佳子、小林　俊介、西澤　知宏、濡木　理、緒方　一博、仙石　徹
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-ORGANIZER-21H05158
[Presentation] NSD2によるヌクレオソーム上H3 Lys36メチル化の構造基盤2022
- Author(s)
  仙石徹
- Organizer
  日本エピジェネティクス研究会
- Data Source
  KAKENHI-PLANNED-21H05161
[Presentation] NSD2によるヌクレオソーム上H3 Lys36メチル化の構造基盤2022
- Author(s)
  仙石徹
- Organizer
  日本エピジェネティクス研究会
- Data Source
  KAKENHI-ORGANIZER-21H05158
[Presentation] NSD2/MMSETによるヌクレオソーム上H3K36メチル化とその制御の構造基盤2022
- Author(s)
  仙石徹
- Organizer
  日本生化学会
- Invited
- Data Source
  KAKENHI-ORGANIZER-21H05158
[Presentation] ヌクレオソーム上H2Bモノユビキチン化の構造基盤2022
- Author(s)
  大西　修平、内山　琴音、佐藤　光、岡田　千佳子、小林　俊介、西澤　知宏、濡木　理、緒方　一博、仙石　徹
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PLANNED-21H05161
[Presentation] LECのコンポーネントICE2による転写終結制御機構の解明2022
- Author(s)
  寺内佑希, 仙石徹, 緒方一博, 鈴木秀文, 小川真太郎, 高橋秀尚
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-ORGANIZER-21H05158
[Presentation] NSD2/MMSETによるヌクレオソーム上H3K36メチル化とその制御の構造基盤2022
- Author(s)
  仙石徹
- Organizer
  日本生化学会
- Invited
- Data Source
  KAKENHI-PLANNED-21H05161
[Presentation] リボソーム合成と生理活性フォルダマーペプチドの発見2021
- Author(s)
  仙石　徹
- Organizer
  第59回SPring-8先端利用技術ワークショップ/大阪大学タンパク質研究所セミナー
- Data Source
  KAKENHI-PROJECT-18K19305
[Presentation] TGIF-1 天然変性領域のリン酸化による機能制御機構の解析 / Molecular mechanism of functional regulation of TGIF-1 by phosphorylation on its intrinsically disordered region2021
- Author(s)
  中野雄太、謝祺琳、酒井佑介、仙石徹、笠原浩太、肥後順一、高橋卓也
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20K12069
[Presentation] NSD2によるヌクレオソーム上H3 Lys36メチル化の構造基盤2021
- Author(s)
  佐藤光, Amarjeet Kumar, 濱田恵輔, 岡田千佳子, 小國麻子, 町山歩, 櫻庭俊, 西澤知宏, 濡木理, 河野秀俊, 緒方一博, 仙石徹
- Organizer
  日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05394
[Presentation] NSD2によるヌクレオソーム上H3 Lys36メチル化の構造基盤2021
- Author(s)
  佐藤光、Amarjeet Kumar、濱田恵輔、岡田千佳子、小國麻子、町山歩、櫻庭俊、西澤知宏、濡木理、河野秀俊、緒方一博、仙石徹
- Organizer
  日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-ORGANIZER-21H05158
[Presentation] Molecular dynamics simulation of phosphorylated and unmodified intrinsically disordered region of TGIF-1 with its homeodomain2021
- Author(s)
  中野雄太、謝祺琳、酒井佑介、笠原浩太、仙石徹、肥後順一、高橋卓也
- Organizer
  第59回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-20K12069
[Presentation] AlphaFoldの医学・生物学・工学研究への応用2021
- Author(s)
  仙石徹
- Organizer
  日本分子生物学会年会
- Data Source
  KAKENHI-ORGANIZER-21H05158
[Presentation] Molecular Dynamics Study on Functional Regulation of Transcription Factors by Phosphorylation on the Intrinsically Disordered Region2020
- Author(s)
  Kota Kasahara, Toru Sengoku, Junichi Higo, Takuya Takahashi, Kazuhiro Ogata, Haruki Nakamura
- Organizer
  第20回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20K12069
[Presentation] Phosphorylation on an intrinsically disordered region regulates the DNA binding activity of a transcription factor via transient interactions.2020
- Author(s)
  Kota Kasahara, Toru Sengoku, Qilin Xie, Yuta Nakano, Ryotaro Koike, Satoshi Fukuchi, Junichi Higo, Masafumi Nakayama, Kazuhiro Ogata, Takuya Takahashi
- Organizer
  第9回生命医薬情報学連合大会
- Data Source
  KAKENHI-PROJECT-20K12069
[Presentation] 乳酸に対する新たな視点とその応用2020
- Author(s)
  仙石　徹
- Organizer
  木原記念横浜生命科学振興財団オンラインセミナー
- Data Source
  KAKENHI-PROJECT-18K19305
[Presentation] Analysis of target DNA recognition mechanism by Nrf2-small Maf heterodimer using fragment molecular orbital (FMO) method2019
- Author(s)
  Sengoku T, Moriwaki H, Watanabe C, Honma T, Ogata K
- Organizer
  CBI学会2019年大会
- Data Source
  KAKENHI-PROJECT-18K19305
[Presentation] Nrf2-小Mafヘテロ二量体による標的DNA認識機構のFMO法（フラグメント分子軌道法）による解析2019
- Author(s)
  仙石　徹，森脇寛智，渡邊千鶴，本間光貴，緒方一博
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K19305
[Presentation] トリプトファンプレニル基転移酵素の結晶構造解析2019
- Author(s)
  濱田恵輔，岡田千佳子，井上澄香，後藤佑樹，菅裕明，緒方一博，仙石徹
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K19305
[Presentation] Structural basis for the recognition of the antioxidant response element by the Nrf2-MafG heterodimer2018
- Author(s)
  Sengoku T, Shiina M, Uchiyama A, Baba S, Okada C, Sato K, Hamada K, Ogata K
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H03293
[Presentation] メチル基を数える: ヒストンH4K20のメチル化状態を特異的に認識する抗体の構造2018
- Author(s)
  仙石徹，渡邉千鶴，馬場しほ，本間光貴，緒方一博，木村宏，横山茂之
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16H03293
[Presentation] メチル基を数える: ヒストンH4K20のメチル化状態を特異的に認識する抗体の構造2018
- Author(s)
  仙石徹，渡邉千鶴，馬場しほ，本間光貴，緒方一博，木村宏，横山茂之
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K19305
[Presentation] Structural basis for the recognition of the antioxidant response element by the Nrf2-MafG heterodimer.2018
- Author(s)
  Sengoku T, Shiina M, Uchiyama A, Baba S, Okada C, Sato K, Hamada K, Ogata K
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K19305
[Presentation] EarPによる翻訳因子EF-PのArg32ラムノシル化の構造的基盤2017
- Author(s)
  仙石徹・鈴木健裕・堂前直・渡邉千鶴・本間光貴・疋田泰士・山口芳樹・高橋英之・横山茂之・柳沢達男
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15K21626
[Presentation] Structural basis for activation of Neisseria meningitides elongation factor P with arginine-32 rhamnosylation by EarP2017
- Author(s)
  Toru Sengoku
- Organizer
  3rd International Symposium of Medicinal Sciences
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21626
[Presentation] 髄膜炎菌由来の翻訳因子EF-Pのラムノース修飾による活性化の構造的基盤2016
- Author(s)
  仙石徹・柳沢達男・鈴木健裕・疋田泰士・渡邉千鶴・本間光貴・堂前直・高橋秀幸・横山茂之
- Organizer
  日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K21626
[Presentation] 構造生物学分野からの期待　ヒストンメチル化因子を例にして2014
- Author(s)
  仙石徹
- Organizer
  セミナー　FMO法を用いた超分解能結晶構造解析の実現に向けて
- Place of Presentation
  理化学研究所横浜キャンパス
- Year and Date
  2014-08-28
- Invited
- Data Source
  KAKENHI-PUBLICLY-25121740
[Presentation] 創薬におけるX線結晶構造解析手法の課題と”超分解能解析”2014
- Author(s)
  仙石徹
- Organizer
  第５回神戸大学統合研究拠点サロン
- Place of Presentation
  第５回神戸大学統合研究拠点
- Year and Date
  2014-11-17
- Invited
- Data Source
  KAKENHI-PUBLICLY-25121740
[Presentation] Structural Basis for Histone H3 Lys27 demethylation by UTX/KDM6A2013
- Author(s)
  Toru Sengoku and Shigeyuki Yokoyama
- Organizer
  ICSG2013
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23770131
[Presentation] Structural Basis for Histone H3 Lys27 demethylation by UTX/KDM6A2013
- Author(s)
  Toru Sengoku and Shigeyuki Yokoyama
- Organizer
  Fujihara Seminar
- Place of Presentation
  苫小牧
- Data Source
  KAKENHI-PROJECT-23770131
[Presentation] Structural Basis for Histone H3 Lys27 demethylation by UTX/KDM6A2011
- Author(s)
  仙石徹、横山茂之
- Organizer
  日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-23770131
[Presentation] Structural Basis for demethylation of Histone H3 Lys27 by UTX/KDM6A2011
- Author(s)
  仙石徹、横山茂之
- Organizer
  第５回日本エピジェネティクス研究会年会
- Place of Presentation
  KKRホテル熊本
- Data Source
  KAKENHI-PROJECT-23770131
[Presentation] Structural Basis for demethylation of Histone H3 Lys27 by UTX/KDM6A2011
- Author(s)
  Toru Sengoku, Shigeyuki Yokoyama
- Organizer
  第３４回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23770131
[Presentation] Structural Basis for Histone H3 Lys27 demethylation by UTX/KDM6A2011
- Author(s)
  仙石徹、横山茂之
- Organizer
  日本エピジェネティクス研究会年会
- Place of Presentation
  熊本
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-23770131

1. 浜田恵輔 (00344052)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
2. OGATA Kazuhiro (90260330)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
3. 椎名政昭 (30347299)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 笠原浩太 (90634965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 菅裕明 (00361668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 二村圭祐 (00462713)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 高橋秀尚 (30423544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. チョンピンフィー

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 河野秀俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 松本直通

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 宮武聡子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sengoku Toru 仙石 徹

SENGOKU Toru 仙石 徹

Research Projects

Research Products

Co-Researchers

ペプチド創薬に応用可能なペプチドプレニル基転移酵素群の構造生物学的解析

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Structural elucidation of the multi-subunit interactions that establish the transcriptional unity mechanismPrincipal Investigator

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Elucidation of the mechanisms of transcriptional unity by understanding spatiotemporal multifactorial interactions

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トリプトファンプレニル基転移酵素のペプチド基質認識と反応機構の構造学的解明

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Study of the phosphorylation latch mechanism for the transcriptional regulation via intrinsically disordered regions

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Challenges to the remaining issues of therapeutically valuable pseudo-natural peptides and products

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Mechanisms that establish, maintain, and dysregulate histone methylation statesPrincipal Investigator

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Study of the mechanism of nucleosome-enhanceosome conversion

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Search for anti-leukemic drugs targeting the cancer-related transcription factor Runx1/CBFbeta

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Reaction mechanism and inhibitor development of a histone demethylasePrincipal Investigator

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ヒストンメチル化酵素複合体の構造解析Principal Investigator

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Structural and functional analyses of a histone demethylase that regulates cell differentiationPrincipal Investigator

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[Journal Article] Brain monoamine vesicular transport disease caused by homozygous SLC18A2 variants: A study in 42?affected individuals2023

Author(s)

Journal Title

Sengoku Toru 仙石徹

SENGOKU Toru 仙石徹