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Asakawa Daiki  浅川 大樹

ORCIDConnect your ORCID iD *help
Researcher Number 60584365
Other IDs
Affiliation (Current) 2025: 国立研究開発法人産業技術総合研究所, 計量標準総合センター, 上級主任研究員
Affiliation (based on the past Project Information) *help 2022 – 2024: 国立研究開発法人産業技術総合研究所, 計量標準総合センター, 上級主任研究員
2020 – 2021: 国立研究開発法人産業技術総合研究所, 計量標準総合センター, 主任研究員
2017 – 2018: 国立研究開発法人産業技術総合研究所, 計量標準総合センター, 主任研究員
2015 – 2016: 国立研究開発法人産業技術総合研究所, 分析計測標準研究部門, 主任研究員
2014: 独立行政法人理化学研究所, 生命システム研究センター, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 34020:Analytical chemistry-related / Analytical chemistry / オミクス計測科学
Except Principal Investigator
Basic Section 34020:Analytical chemistry-related
Keywords
Principal Investigator
気相イオン / 質量分析 / ペプチド / 翻訳後修飾 / タンデム質量分析法 / ラジカル / リン酸化ペプチド / 密度汎関数理論 / 電子捕獲解離 / 電子移動解離 … More / タンデム質量分析 / 金属-ペプチド複合体 / 圧力 / 内部エネルギー分布 / 温度計イオン / エレクトロスプレー / クロマトグラフィー / エレクトロスプレーイオン化 / マトリックス支援レーザー脱離イオン化 / ラジカル分解 / タンパク質 / ラジカル化 / 密度半関数理論 / フラグメンテーション / 金属結合サイト / Mass Spectrometry / Analytical Chemistry … More
Except Principal Investigator
モノクローナル抗体 / 翻訳後修飾 / 放射線 / ペプチドマッピング / 構造解析 / 質量分析 / イオン化法の開発 / 温度可変のネイティブ質量分析 Less
  • Research Projects

    (6 results)
  • Research Products

    (38 results)
  • Co-Researchers

    (7 People)
  •  Development of variable-temperature native mass spectrometry toward the evaluation of protein properties in crowding biosystems

    • Principal Investigator
      末松 和美 (七種和美)
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 34020:Analytical chemistry-related
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Improvement of Electrospray Ionization Mass Spectrometry by Controlling the Temperature of Gas Phase IonsPrincipal Investigator

    • Principal Investigator
      浅川 大樹
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 34020:Analytical chemistry-related
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Characterization of structural changes in irradiated monoclonal antibody by mass spectrometry.

    • Principal Investigator
      絹見 朋也
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 34020:Analytical chemistry-related
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Development of Sulfoprotein Analytical MethodsPrincipal Investigator

    • Principal Investigator
      Asakawa Daiki
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 34020:Analytical chemistry-related
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Development of radical induced dissociation tandem mass spectrometryPrincipal Investigator

    • Principal Investigator
      Asakawa Daiki
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Analytical chemistry
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Analysis of Metal-binding Proteins by Mass SpectrometryPrincipal Investigator

    • Principal Investigator
      Asakawa Daiki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      オミクス計測科学
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
      The Institute of Physical and Chemical Research

All 2024 2023 2022 2021 2020 2018 2017 2016 2015 2014

All Journal Article Presentation Patent

  • [Journal Article] Is the first step in MALDI in-source decay electron transfer or hydrogen atom abstraction?2024

    • Author(s)
      Asakawa Daiki
    • Journal Title

      International Journal of Mass Spectrometry

      Volume: 498 Pages: 117202-117202

    • DOI

      10.1016/j.ijms.2024.117202

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K26689
  • [Journal Article] Phenyl Sulfate Derivatives: New Thermometer Ions for Characterization of Internal Energy of Negative Ions Produced by Electrospray Ionization2023

    • Author(s)
      Asakawa Daiki
    • Journal Title

      Journal of the American Society for Mass Spectrometry

      Volume: 34 Issue: 3 Pages: 435-440

    • DOI

      10.1021/jasms.2c00321

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K05575
  • [Journal Article] Differences in the internal energies of ions in electrospray ionization mass spectrometers equipped with capillary-skimmer and capillary-RF lens interfaces2023

    • Author(s)
      Asakawa Daiki、Yamamoto Ryoma、Hanari Nobuyasu、Saikusa Kazumi
    • Journal Title

      Analytical Methods

      Volume: 15 Issue: 45 Pages: 6150-6158

    • DOI

      10.1039/d3ay01450a

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K26689
  • [Journal Article] Pentafluorobenzylpyridinium: new thermometer ion for characterizing the ions produced by collisional activation during tandem mass spectrometry2023

    • Author(s)
      Asakawa Daiki、Saikusa Kazumi
    • Journal Title

      Analytical Sciences

      Volume: 39 Issue: 12 Pages: 2031-2039

    • DOI

      10.1007/s44211-023-00419-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K26689
  • [Journal Article] Characterization of the Internal Energy of Ions Produced by Electrospray Ionization Using Substituted Benzyl Ammonium Thermometer Ions2022

    • Author(s)
      Asakawa Daiki、Saikusa Kazumi
    • Journal Title

      Journal of the American Society for Mass Spectrometry

      Volume: 33 Issue: 8 Pages: 1548-1554

    • DOI

      10.1021/jasms.2c00116

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K05575
  • [Journal Article] Fragmentation of Protonated Histamine and Histidine by Electrospray Ionization In-Source Collision-Induced Dissociation2022

    • Author(s)
      Asakawa Daiki、Todoroki Kenichiro、Mizuno Hajime
    • Journal Title

      Journal of the American Society for Mass Spectrometry

      Volume: 33 Issue: 9 Pages: 1716-1722

    • DOI

      10.1021/jasms.2c00140

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K05575
  • [Journal Article] Experimental and Theoretical Investigation of MALDI In-Source Decay of Peptides with a Reducing Matrix: What Is the Initial Fragmentation Step?2022

    • Author(s)
      Asakawa Daiki、Hosokai Takuya、Nakayama Yasuo
    • Journal Title

      Journal of the American Society for Mass Spectrometry

      Volume: 33 Issue: 6 Pages: 1011-1021

    • DOI

      10.1021/jasms.2c00066

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K05575
  • [Journal Article] Hot Hydrogen Atom Irradiation of Protonated/Deprotonated Peptide in an Ion Trap Facilitates Fragmentation through Heated Radical Formation2022

    • Author(s)
      Asakawa Daiki、Takahashi Hidenori、Iwamoto Shinichi、Tanaka Koichi
    • Journal Title

      Journal of the American Chemical Society

      Volume: 144 Issue: 7 Pages: 3020-3028

    • DOI

      10.1021/jacs.1c11081

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K05575
  • [Journal Article] Fragmentation study of tryptophan-derived metabolites induced by electrospray ionization mass spectrometry for highly sensitive analysis2021

    • Author(s)
      Asakawa Daiki、Mizuno Hajime、Sugiyama Eiji、Todoroki Kenichiro
    • Journal Title

      The Analyst

      Volume: 146 Issue: 7 Pages: 2292-2300

    • DOI

      10.1039/d0an02069a

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K05575, KAKENHI-PROJECT-19K07028
  • [Journal Article] Fragmentation efficiency of phenethylamines in electrospray ionization source estimated by theoretical chemistry calculation2021

    • Author(s)
      Asakawa Daiki、Saikusa Kazumi
    • Journal Title

      Journal of Mass Spectrometry

      Volume: 57 Issue: 1

    • DOI

      10.1002/jms.4802

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K05575
  • [Journal Article] Study of Substituted Phenethylamine Fragmentation Induced by Electrospray Ionization Mass Spectrometry and Its Application for Highly Sensitive Analysis of Neurotransmitters in Biological Samples2021

    • Author(s)
      Asakawa Daiki、Sugiyama Eiji、Mizuno Hajime、Todoroki Kenichiro
    • Journal Title

      Journal of the American Society for Mass Spectrometry

      Volume: 32 Issue: 8 Pages: 2144-2152

    • DOI

      10.1021/jasms.1c00173

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07028, KAKENHI-PROJECT-20K05575
  • [Journal Article] In-Source Fragmentation of Phenethylamines by Electrospray Ionization Mass Spectrometry: Toward Highly Sensitive Quantitative Analysis of Monoamine Neurotransmitters2020

    • Author(s)
      Asakawa Daiki、Mizuno Hajime、Sugiyama Eiji、Todoroki Kenichiro
    • Journal Title

      Analytical Chemistry

      Volume: 92 Issue: 17 Pages: 12033-12039

    • DOI

      10.1021/acs.analchem.0c02667

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07028, KAKENHI-PROJECT-20K05575
  • [Journal Article] Gas-Phase Peptide Fragmentation Induced by Hydrogen Attachment, from Principle to Sequencing of Amide Nitrogen-Methylated Peptides2020

    • Author(s)
      Asakawa Daiki、Takahashi Hidenori、Iwamoto Shinichi、Tanaka Koichi
    • Journal Title

      Analytical Chemistry

      Volume: 92 Issue: 24 Pages: 15773-15780

    • DOI

      10.1021/acs.analchem.0c02766

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K05575
  • [Journal Article] Cooperative dissociation of peptide backbones and side‐chains during matrix‐assisted laser desorption/ionization in‐source decay mediated by hydrogen abstraction2020

    • Author(s)
      Asakawa Daiki
    • Journal Title

      Journal of Mass Spectrometry

      Volume: 56 Issue: 4

    • DOI

      10.1002/jms.4530

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K05575
  • [Journal Article] Ultraviolet-Laser-Induced Electron Transfer from Peptides to an Oxidizing Matrix: Study of the First Step of MALDI In-Source Decay Mass Spectrometry2020

    • Author(s)
      Asakawa Daiki
    • Journal Title

      Journal of the American Society for Mass Spectrometry

      Volume: 31 Issue: 9 Pages: 1918-1926

    • DOI

      10.1021/jasms.0c00186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K05575
  • [Journal Article] De Novo Sequencing of Tryptic Phosphopeptides Using Matrix-Assisted Laser Desorption/Ionization Based Tandem Mass Spectrometry with Hydrogen Atom Attachment2018

    • Author(s)
      Asakawa Daiki、Takahashi Hidenori、Iwamoto Shinichi、Tanaka Koichi
    • Journal Title

      Analytical Chemistry

      Volume: 90 Issue: 4 Pages: 2701-2707

    • DOI

      10.1021/acs.analchem.7b04635

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K14508
  • [Journal Article] Fundamental study of hydrogen-attachment-induced peptide fragmentation occurring in the gas phase and during the matrix-assisted laser desorption/ionization process2018

    • Author(s)
      Asakawa Daiki、Takahashi Hidenori、Iwamoto Shinichi、Tanaka Koichi
    • Journal Title

      Physical Chemistry Chemical Physics

      Volume: 20 Issue: 18 Pages: 13057-13067

    • DOI

      10.1039/c8cp00733k

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K14508
  • [Journal Article] Influence of the metals and ligands in dinuclear complexes on phosphopeptide sequencing by electron-transfer dissociation tandem mass spectrometry2018

    • Author(s)
      Asakawa Daiki、Miyazato Akio、Rosu Frederic、Gabelica Valerie
    • Journal Title

      Physical Chemistry Chemical Physics

      Volume: 20 Issue: 41 Pages: 26597-26607

    • DOI

      10.1039/c8cp04516j

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K14508
  • [Journal Article] Direct MALDI-MS Analysis of the Disulfide Bonds in Peptide Using Thiosalicylic Acid as a Reactive Matrix2017

    • Author(s)
      D. Asakawa, I. Osaka
    • Journal Title

      J. Mass Spectrom.

      Volume: 52 Issue: 2 Pages: 127-131

    • DOI

      10.1002/jms.3906

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26505016
  • [Journal Article] High-Confidence Sequencing of Phosphopeptides by Electon Transfer Dissociation Mass Spectrometry Using Dinuclear Zinc(II) Complex2016

    • Author(s)
      D. Asakawa, I. Osaka
    • Journal Title

      Anal. Chem.

      Volume: 88 Issue: 24 Pages: 12393-12402

    • DOI

      10.1021/acs.analchem.6b03645

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26505016
  • [Journal Article] Difference of Electron Capture and Transfer Dissociation Mass Spectrometry on Ni2+-, Cu2+- and Zn2+-Polyhistidine Complexes in the Absence of Remote Protons2016

    • Author(s)
      D. Asakawa, E. De Pauw
    • Journal Title

      Journal of the American Society for Mass Spectrometry

      Volume: - Issue: 7 Pages: 1165-1175

    • DOI

      10.1007/s13361-016-1395-z

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26505016
  • [Journal Article] N–Cα Bond Cleavage of Zinc-Polyhistidine Complexes in Electron Transfer Dissociation Mediated by Zwitterion Formation. Experimental Evidence and Theoretical Analysis of the Utah-Washington Model2016

    • Author(s)
      D. Asakawa, A. Yamashita, S. Kawai, T. Takeuchi, Y. Wada
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 120 Issue: 5 Pages: 891-901

    • DOI

      10.1021/acs.jpcb.5b11118

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26505016, KAKENHI-PROJECT-15K12446
  • [Journal Article] Estimation of Peptide N-Cα Bond Cleavage Efficiency during MALDI-ISD Using a Cyclic Peptide2016

    • Author(s)
      D. Asakawa, N. Smargiasso, E. De Pauw
    • Journal Title

      Journal of Mass Spectrometry

      Volume: 51 Issue: 5 Pages: 323-327

    • DOI

      10.1002/jms.3748

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26505016
  • [Journal Article] Electron transfer dissociation mass spectrometry of peptides containing free cysteine using group XII metals as a charge carrier2014

    • Author(s)
      Asakawa D, Wada Y.
    • Journal Title

      J Phys Chem B

      Volume: 118 Issue: 43 Pages: 12318-25

    • DOI

      10.1021/jp502818u

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26282136, KAKENHI-PROJECT-26505016
  • [Journal Article] Influence of Metal-Peptide Complexation on Fragmentation and Inter-Fragment Hydrogen Migration in Electron Transfer Dissociation2014

    • Author(s)
      D. Asakawa, T. Takeuchi, A. Yamashita, Y. Wada
    • Journal Title

      J. Am. Soc. Mass Spectrom

      Volume: 25 Issue: 6 Pages: 1029-1039

    • DOI

      10.1007/s13361-014-0855-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J10272, KAKENHI-PROJECT-24619003, KAKENHI-PROJECT-26505016
  • [Patent] 特許2016

    • Inventor(s)
      浅川大樹
    • Industrial Property Rights Holder
      浅川大樹
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-174673
    • Filing Date
      2016-09-07
    • Data Source
      KAKENHI-PROJECT-26505016
  • [Presentation] 水素付着解離タンデム質量分析法による異性化ペプチドの分析2023

    • Author(s)
      浅川大樹、岩本慎一、田中耕一
    • Organizer
      第71回質量分析総合討論会
    • Data Source
      KAKENHI-PROJECT-23K26689
  • [Presentation] Development of Thermometer Ions for the Measurement of Internal Energy Distribution of Ions in Gas Phase2023

    • Author(s)
      Daiki Asakawa
    • Organizer
      令和5年度化学系学協会東北大会及び 日本化学会東北支部80周年記念国際会議
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K26689
  • [Presentation] 気相イオンの内部エネルギー分布測定のための温度計イオンの開発2023

    • Author(s)
      浅川大樹
    • Organizer
      マイクロビームアナリシス技術部会 第13回研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K26689
  • [Presentation] 気相イオンの内部エネルギー分布測定のための温度計イオンの開発2023

    • Author(s)
      浅川大樹
    • Organizer
      第71回質量分析総合討論会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K26689
  • [Presentation] Development of Thermometer Ions for the Measurement of Ion’s Internal Energy2023

    • Author(s)
      Daiki Asakawa
    • Organizer
      アジアオセアニア質量分析国際会議
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K26689
  • [Presentation] Dissociation of Hydrogen-Abundant Peptide Radical Formed by Hydrogen Attachment in Gas Phase2018

    • Author(s)
      Asakawa Daiki、Takahashi Hidenori、Iwamoto Shinichi、Tanaka Koichi, Kamiya Katsumasa
    • Organizer
      22th International Mass Spectrometry Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K14508
  • [Presentation] Fundamental Study of Hydrogen Attachment/Abstraction Dissociation (HAD) Tandem Mass Spectrometry by Ab initio Calculation2018

    • Author(s)
      Asakawa Daiki、Takahashi Hidenori、Iwamoto Shinichi、Tanaka Koichi, Kamiya Katsumasa
    • Organizer
      ASMS Sanibel Conference
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K14508
  • [Presentation] Fundamental Study of Hydrogen Attachment/Abstraction Dissociation (HAD) Tandem Mass Spectrometry by Ab initio Calculation2018

    • Author(s)
      D. Asakawa, H. Takahashi, S. Iwamoto, K. Tanaka, K. Kamiya
    • Organizer
      ASMS Sanibel Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K14508
  • [Presentation] Density functional theory calculation, Metal reduction, Zwitterion formation, Hydrogen radical loss, Peptide bond cleavage2016

    • Author(s)
      Daiki Asakawa, Edwin De Pauw
    • Organizer
      64th ASMS Conference
    • Place of Presentation
      San Antonio, TX, USA
    • Year and Date
      2016-06-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26505016
  • [Presentation] プロトンを含まない亜鉛-ポリヒスチジン複合体の電子捕獲・電子移動解離過程2016

    • Author(s)
      浅川 大樹、De Pauw, Edwin
    • Organizer
      日本質量分析学会総合討論会
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪府吹田市)
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-26505016
  • [Presentation] 金属錯体添加を利用した電子移動解離タンデム質量分析法によるリン酸化ペプチドのアミノ酸配列解析2016

    • Author(s)
      浅川大樹、大坂一生
    • Organizer
      新アミノ酸分析研究会第6回学術講演会
    • Place of Presentation
      ホテル阪急エキスポパーク(東京都文京区)
    • Data Source
      KAKENHI-PROJECT-26505016
  • [Presentation] 金属-ペプチド複合体を用いた電子移動解離質量分析法の本質解明に向けたアプローチ2015

    • Author(s)
      浅川大樹、山下明日香、和田芳直、竹内孝江
    • Organizer
      第63回質量分析総合討論会
    • Place of Presentation
      茨城県つくば市
    • Year and Date
      2015-06-15
    • Data Source
      KAKENHI-PROJECT-26505016
  • 1.  末松 和美 (60608769)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  絹見 朋也 (90293125)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  川崎 ナナ (20186167)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  加藤 昌弘 (70392602)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  山口 英俊 (10783194)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  MIZUNO Hajime
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 7.  和田 健彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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