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Ishino Kousuke  石野 孔祐

… Alternative Names

ISHINO Kousuke  石野 孔祐

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Researcher Number 60584878
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-6862-9898
Affiliation (Current) 2025: 日本医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help 2018 – 2024: 日本医科大学, 医学部, 講師
2017: 日本医科大学, 医学部, 助教
2013: 日本医科大学, 医学部, 助教
2011 – 2012: 独立行政法人国立がん研究センター, 研究所, 研究員
Review Section/Research Field
Principal Investigator
Experimental pathology / Risk sciences of radiation/Chemicals
Except Principal Investigator
Basic Section 49030:Experimental pathology-related / Basic Section 58010:Medical management and medical sociology-related / Basic Section 56040:Obstetrics and gynecology-related / Basic Section 55010:General surgery and pediatric surgery-related / Legal medicine
Keywords
Principal Investigator
酸化ストレス / ドライバー遺伝子 / 活性酸素種(ROS) / N-アセチルシステイン(NAC) / シスプラチン / A549細胞 / MIAPaCa2 細胞 / 抗がん剤感受性 / 2-デオキシ-D-グルコース(2DG) / 抗酸化代謝物 … More / 抗がん剤耐性 / 相乗効果 / 併用投与 / がん代謝 / メトホルミン / 膵がん細胞株 / 2-デオキシグルコース / アダクトーム解析 / マグネタイト / アダクトミクス / LC-MS/MS / ナノマテリアル / 突然変異 / DNA付加体 … More
Except Principal Investigator
host factor / capsid / proteomics / host factor / bat / HIV-1 / retrovirus / 領域横断 / 情報集積 / 薬毒物情報 / 市販薬 / OTC薬 / 内在性ウイルス / マルチオミックス解析 / エクソソーム / 胎盤形成不全 / 妊娠高血圧症候群 / 電子顕微鏡 / オートファジー / 甲状腺癌 / GC-MS / 法医中毒学 / S酸化物 / GC/MS / QTOF-LC/MS / データベース構築 / QTOF / データベースライブラリ / LC-QTOF / 代謝物予測 / 酸素付加体 / S酸化 / クエチアピン / Q-TOF / 代謝物解析 / ホルマリン保存 Less
  • Research Projects

    (7 results)
  • Research Products

    (40 results)
  • Co-Researchers

    (8 People)
  •  甲状腺癌細胞におけるオートファジーの役割解明および電顕による形態評価

    • Principal Investigator
      大橋 隆治
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Nippon Medical School
  •  Multiomics analysis of exosome-delivering, virus-derived factors in the feto-matarnal interface for hypertensive dosorder of pregnancy

    • Principal Investigator
      磯村 真理子
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Nippon Medical School
  •  薬毒物情報の領域横断的集積化へ向けた試み -One for all, all for one-

    • Principal Investigator
      植草 協子
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 58010:Medical management and medical sociology-related
    • Research Institution
      Nippon Medical School
  •  コウモリ細胞ライブラリ由来の宿主因子によるHIV-1キャプシド標的抑制分子の作出

    • Principal Investigator
      大倉 定之
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Nippon Medical School
  •  Construction and verification of a database library of drugs and metabolites detected in formalin tissues and fixatives utilizing in silico analysis

    • Principal Investigator
      UEKUSA Kyoko
    • Project Period (FY)
      2017 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Legal medicine
    • Research Institution
      Nippon Medical School
  •  Effect of redox metabolic flux regulated by cancer metabolism on anticancer drug resistancePrincipal Investigator

    • Principal Investigator
      Ishino Kousuke
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Nippon Medical School
  •  Formation of DNA adducts and mechanism of mutagenesis induced by nanomaterialsPrincipal Investigator

    • Principal Investigator
      ISHINO Kousuke
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Nippon Medical School
      National Center of Neurology and Psychiatry

All 2022 2021 2020 2019 2018 2017 2014 2013 2012 2011

All Journal Article Presentation

  • [Journal Article] High Expression of p21 as a Potential Therapeutic Target in Ovarian Clear-cell Carcinoma2020

    • Author(s)
      MINAGAWA YUKI、ISHINO KOUSUKE、WADA RYUICHI、KUDO MITSUHIRO、NAITO ZENYA、TAKESHITA TOSHIYUKI、OHASHI RYUJI
    • Journal Title

      Anticancer Research

      Volume: 40 Issue: 10 Pages: 5631-5639

    • DOI

      10.21873/anticanres.14576

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09279
  • [Journal Article] Downregulation of protein disulfide-isomerase A3 expression inhibits cell proliferation and induces apoptosis through STAT3 signaling in hepatocellular carcinoma2019

    • Author(s)
      Kondo R, Ishino K, Wada R, Takata H, Peng WX, Kudo M, Kure S, Kaneya Y, Taniai N, Yoshida H, Naito Z
    • Journal Title

      International Journal of Oncology

      Volume: 54 Pages: 1409-1421

    • DOI

      10.3892/ijo.2019.4710

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09279, KAKENHI-PROJECT-17K15673, KAKENHI-PROJECT-16K10479, KAKENHI-PROJECT-15K10735
  • [Journal Article] DNA Adductome Analysis Identifies N-Nitrosopiperidine Involved in the Etiology of Esophageal Cancer in Cixian, China2019

    • Author(s)
      Totsuka Y, Lin Y, He Y, Ishino K, Sato H, Kato M, Nagai M, Elzawahry A, Totoki Y, Nakamura H, Hosoda F, Shibata T, Matsuda T, Matsushima Y, Song G, Meng F, Li D, Liu J, Qiao Y, Wei W, Inoue M, Kikuchi S, Nakagama H, Shan B
    • Journal Title

      Chemical Research in Toxicology

      Volume: 32 Issue: 8 Pages: 1515-1527

    • DOI

      10.1021/acs.chemrestox.9b00017

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09279
  • [Journal Article] Farnesoid X receptor induces cell death and sensitizes to TRAIL-induced inhibition of growth in colorectal cancer cells through the up-regulation of death receptor 5.2019

    • Author(s)
      Hotta M, Sakatani T, Ishino K, Wada R, Kudo M, Yokoyama Y, Yamada T, Yoshida H, Naito Z
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 519 Issue: 4 Pages: 824-831

    • DOI

      10.1016/j.bbrc.2019.09.033

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K10479, KAKENHI-PROJECT-17K15673
  • [Journal Article] Expression of protein disulfide isomerase A3 and its clinicopathological association in gastric cancer2019

    • Author(s)
      Shimoda Tomohiro、Wada Ryuichi、Kure Shoko、Ishino Kousuke、Kudo Mitsuhiro、Ohashi Ryuji、Fujita Itsuo、Uchida Eiji、Yoshida Hiroshi、Naito Zenya
    • Journal Title

      Oncology Reports

      Volume: 41 Pages: 2265-2272

    • DOI

      10.3892/or.2019.6999

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K15673, KAKENHI-PROJECT-16K10479
  • [Journal Article] Nuclear Morphological Changes in Papillary Thyroid Carcinoma Cell: The Utility of a 3-Dimensional (3D) Holographic Microscopy in Cytology2018

    • Author(s)
      Kure Shoko、Kudo Mitsuhiro、Ishino Kousuke、Wada Ryuichi、Naito Zenya
    • Journal Title

      Journal of Cytology & Histology

      Volume: 09 Issue: 06 Pages: 527-527

    • DOI

      10.4172/2157-7099.1000527

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K15673
  • [Journal Article] Expression of DNA damage response proteins in gastric cancer: Comprehensive protein profiling and histological analysis2018

    • Author(s)
      Arai Hiroki、Wada Ryuichi、Ishino Kousuke、Kudo Mitsuhiro、Uchida Eiji、Naito Zenya
    • Journal Title

      International Journal of Oncology

      Volume: 52 Pages: 978-988

    • DOI

      10.3892/ijo.2018.4238

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09279, KAKENHI-PROJECT-17K15673, KAKENHI-PROJECT-16K10479
  • [Journal Article] 2-Deoxy-D-glucose increases GFAT1 phosphorylation resulting in endoplasmic reticulum-related apoptosis via disruption of protein N-glycosylation in pancreatic cancer cells2018

    • Author(s)
      Ishino K, Kudo M, Peng WX, Kure S, Kawahara K, Teduka K, Kawamoto Y, Kitamura T, Fujii T, Yamamoto T, Wada R, Naito Z
    • Journal Title

      Biochem Biophys Res Comm

      Volume: 501 Issue: 3 Pages: 668-673

    • DOI

      10.1016/j.bbrc.2018.05.041

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K10479, KAKENHI-PROJECT-17K09279, KAKENHI-PROJECT-17K15673, KAKENHI-PROJECT-15K10735
  • [Journal Article] Magnetite Nanoparticles Induce Genotoxicity in the Lungs of Mice via Inflammatory Response2014

    • Author(s)
      Totsuka Y, Ishino K, Kato T, Goto S, Tada Y, Nakae D, Watanabe M, Wakabayashi K
    • Journal Title

      Nanomaterials

      Volume: 4 Issue: 1 Pages: 175-188

    • DOI

      10.3390/nano4010175

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23710084, KAKENHI-PROJECT-24592379
  • [Journal Article] Genotoxicity and reactive oxygen species production induced by magnetite nanoparticles in mammalian cells2013

    • Author(s)
      Kawanishi M, Ogo S, Ikemoto M, Totsuka Y, Ishino K, Wakabayashi K, Yagi T
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 38 Issue: 3 Pages: 503-511

    • DOI

      10.2131/jts.38.503

    • NAID

      10031158916

    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23710084, KAKENHI-PROJECT-24310047
  • [Journal Article] Genotoxicity of multi-walled carbon nanotubes in both in vitro and in vivo assay systems2012

    • Author(s)
      Kato, T., et al
    • Journal Title

      Nanotoxicology

      Volume: (in press) Issue: 4 Pages: 452-461

    • DOI

      10.3109/17435390.2012.674571

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23221006, KAKENHI-PROJECT-23500964, KAKENHI-PROJECT-23710081, KAKENHI-PROJECT-23710084
  • [Journal Article] In Vitro and In Vivo Genotoxicity Induced by Fullerene (C60) and Kaolin2011

    • Author(s)
      Totsuka Y, Kato T, Masuda S, Ishino K, Matsumoto Y, Goto S, Kawanishi M, Tagi T, Wakabayashi K
    • Journal Title

      Genes and Environment

      Volume: 33 Issue: 1 Pages: 14-20

    • DOI

      10.3123/jemsge.33.14

    • NAID

      10027955671

    • ISSN
      1880-7046, 1880-7062
    • Language
      English
    • Data Source
      KAKENHI-PROJECT-23710084
  • [Presentation] Metabolic disorder by 2-deoxyglucose induces endoplasmic reticulum stress-related apoptosis in pancreatic cancer cells2022

    • Author(s)
      Kousuke Ishino, Mitsuhiro Kudo, Akira Matsushita, Hiroshi Yoshida, Ryuji Ohashi
    • Organizer
      第81回日本癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K09279
  • [Presentation] 膵癌細胞株において2-デオキシ-D-グルコースはヘキソサミン合成経路を介して小胞体ストレス関連細胞死を誘発する2021

    • Author(s)
      石野孔祐、工藤光洋、大橋隆治
    • Organizer
      第89回日本医科大学医学会総会
    • Data Source
      KAKENHI-PROJECT-17K09279
  • [Presentation] Verification of a database library of drugs and metabolites detected in formalin tissues and fixatives constructed utilizing in silico analysis2021

    • Author(s)
      Kyoko UEKUSA, Masahiko TAKINO, Kousuke ISHINO, Yoshimasa KANAWAKU
    • Organizer
      100. Jahrestagung der Deutschen Gesellschaft fur Rechtsmedizin(第100次ドイツ法医学会)
    • Data Source
      KAKENHI-PROJECT-17K09279
  • [Presentation] In silico 解析を活用し構築したホルマリン臓器中の薬物および代謝物のデ ータベースライブラリの検証2020

    • Author(s)
      植草協子、滝埜昌彦、石野孔祐、金涌佳雅
    • Organizer
      第104次日本法医学会学術全国集会
    • Data Source
      KAKENHI-PROJECT-17K09279
  • [Presentation] In silico 解析を活用したホルマリン臓器中の薬物および代謝物のデータベース検索2019

    • Author(s)
      植草協子、石野孔祐、内藤善哉、金涌佳雅
    • Organizer
      第 87 回日本医科大学医学会総会
    • Data Source
      KAKENHI-PROJECT-17K09279
  • [Presentation] 膵癌細胞株において2-デオキシ-D-グルコースはGFAT1リン酸化を介して小胞体ストレス関連細胞死を誘発する2018

    • Author(s)
      石野孔祐、工藤光洋、彭為霞、呉壮香、和田龍一、内藤善哉
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K15673
  • [Presentation] 質量分析データに基づくDNA付加体データベースの整備2018

    • Author(s)
      石野孔祐、前迫侑也、内藤善哉、戸塚ゆ加里
    • Organizer
      日本環境変異原学会 第47回大会
    • Data Source
      KAKENHI-PROJECT-17K15673
  • [Presentation] 有棘細胞癌におけるTLR4の発現と機能についての検討2018

    • Author(s)
      三神絵理奈、工藤光洋、大橋隆治、川原清子、河本陽子、手塚潔、藤井雄文、呉壮香、石野孔祐、坂谷貴司、和田龍一、佐伯秀久、内藤善哉
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K15673
  • [Presentation] 肝細胞癌におけるSTAT3経路を介したPDIA3による細胞増殖とアポトーシスの制御2018

    • Author(s)
      近藤亮太、石野孔祐、和田龍一、工藤光洋、内藤善哉
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K15673
  • [Presentation] 膵癌細胞株において2-デオキシ-D-グルコースはGFAT1リン酸化を介して小胞体ストレス関連細胞死を誘発する2018

    • Author(s)
      石野孔祐、工藤光洋、彭為霞、呉壮香、和田龍一、内藤善哉
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K09279
  • [Presentation] QTOF解析ソフトを用いたホルマリン臓器中の薬物および代謝物の検索2018

    • Author(s)
      植草協子, 滝埜昌彦, 中園裕紀子, 石野孔祐, 林田眞喜子, 大野曜吉
    • Organizer
      第87回 日本法医学会学術関東地方集会
    • Data Source
      KAKENHI-PROJECT-17K09279
  • [Presentation] 質量分析データに基づくDNA付加体データベースの整備2018

    • Author(s)
      石野孔祐、前迫侑也、内藤善哉、戸塚ゆ加里
    • Organizer
      日本環境変異原学会 第47回大会
    • Data Source
      KAKENHI-PROJECT-17K09279
  • [Presentation] 肝細胞癌においてPDIA3はJak/STAT経路の活性化を介し細胞増殖能を制御する2018

    • Author(s)
      近藤亮太、石野孔祐、金谷洋平、高田英志、彭為霞、工藤光洋、和田龍一、谷合信彦、内田英二、内藤善哉
    • Organizer
      第107回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-17K15673
  • [Presentation] Proteomic analysis reveals protein A as a potential prognostic biomarker for endometrioid carcinoma2018

    • Author(s)
      Wei-Xia Peng、Kousuke Ishino、Shoko Kure、Takenori Fujii、Kiyoshi Teduka、Mitsuhiro Kudo、Ryuichi Wada、Zenya Naito
    • Organizer
      United States and Canadian Academy of Pathology 2018 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15673
  • [Presentation] 40歳未満の乳頭癌におけるBRAF遺伝子変異と臨床病理学的因子の関連についての検討2018

    • Author(s)
      呉壮香、和田龍一、彭為霞、石野孔祐、工藤光洋、杉谷巌、内藤善哉
    • Organizer
      第6回日本甲状腺病理学会総会・学術総会
    • Data Source
      KAKENHI-PROJECT-17K15673
  • [Presentation] 液状検体で利用可能な新規膵がん腫瘍マーカーのタンパク質網羅的探索2017

    • Author(s)
      石野孔祐、工藤光洋、彭為霞、呉壮香、河本陽子、手塚潔、藤井雄文、恩田宗彦、和田龍一、内藤善哉
    • Organizer
      第106回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-17K15673
  • [Presentation] 胃癌におけるDNA損傷応答関連分子の発現:網羅的蛋白発現解析と病理組織学的検討2017

    • Author(s)
      新井洋紀、和田龍一、石野孔祐、工藤光洋、内藤善哉
    • Organizer
      第63回日本病理学会秋期特別総会
    • Data Source
      KAKENHI-PROJECT-17K15673
  • [Presentation] 液状検体で利用可能な新規膵がん腫瘍マーカーのタンパク質網羅的探索2017

    • Author(s)
      石野孔祐、工藤光洋、彭為霞、呉壮香、河本陽子、手塚潔、藤井雄文、恩田宗彦、和田龍一、内藤善哉
    • Organizer
      第106回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-17K09279
  • [Presentation] 肝細胞癌においてPDIA3はJak/STAT経路の活性化を介し細胞増殖能を制御する2017

    • Author(s)
      近藤亮太、石野孔祐、金谷洋平、高田英志、彭為霞、工藤光洋、和田龍一、谷合信彦、内田英二、内藤善哉
    • Organizer
      第106回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-17K15673
  • [Presentation] DNA付加体の網羅的解析による新規付加体の探索2012

    • Author(s)
      石野孔祐、関根彬弘、後藤純雄、中釜 斉、戸塚ゆ加里
    • Organizer
      第41回大会日本環境変異原学会
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-23710084
  • [Presentation] Analysis of DNA damage induced by nanomaterials using comprehensive analysis of DNA adducts (DNA adductome analysis)2012

    • Author(s)
      Ishino K, Sekine A, Goto S, Nakagama H, Totsuka Y
    • Organizer
      3rd Asian Conference on environmental mutagens
    • Place of Presentation
      中国杭州
    • Data Source
      KAKENHI-PROJECT-23710084
  • [Presentation] Analysis of DNA damage induced by nanomaterials using comprehensive analysis of DNA adducts (DNA adductome analysis)2012

    • Author(s)
      Kousuke Ishino, Akihiro Sekine, Sumio Goto, Hitoshi Nakagama, Yukari Totsuka
    • Organizer
      3rd Asian Conference on Environmental Mutagens
    • Place of Presentation
      Hangzhou, China
    • Data Source
      KAKENHI-PROJECT-23710084
  • [Presentation] DNA付加体の網羅的解析による新規付加体の探索2012

    • Author(s)
      石野孔祐、関根彬弘、後藤純雄、中釜斉、戸塚ゆ加里
    • Organizer
      日本環境変異原学会第41回大会
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-23710084
  • [Presentation] ナノマテリアルによりマウス肺に誘発されるDNA付加体の網羅的解析2011

    • Author(s)
      石野孔祐、加藤竜也、松田知成、戸塚ゆ加里、中釜斉
    • Organizer
      日本環境変異原学会第40回大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23710084
  • [Presentation] ナノマテリアルにより誘発されるDNA付加体の網羅的解析2011

    • Author(s)
      石野孔祐
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-05
    • Data Source
      KAKENHI-PROJECT-23710084
  • [Presentation] A comprehensive analysis of DNAadducts in mice exposed to nanomaterials2011

    • Author(s)
      石野孔祐、戸塚ゆ加里、加藤竜也、中釜斉
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23710084
  • [Presentation] ナノマテリアルによりマウス肺に誘発されるDNA付加体の網羅的解析2011

    • Author(s)
      石野孔祐
    • Organizer
      第59回質量分析総合討論会
    • Place of Presentation
      吹田
    • Year and Date
      2011-09-13
    • Data Source
      KAKENHI-PROJECT-23710084
  • [Presentation] ナノマテリアルによりマウス肺に誘発される DNA付加体の網羅的解析2011

    • Author(s)
      石野孔祐、加藤竜也、戸塚ゆ加里、中釜斉
    • Organizer
      第59回質量分析総合討論会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-23710084
  • 1.  UEKUSA Kyoko (50409215)
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  • 2.  大倉 定之 (10731036)
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  • 3.  大橋 隆治 (00328783)
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  • 4.  磯村 真理子 (90893222)
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  • 5.  堀江 真行 (20725981)
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  • 6.  根岸 靖幸 (50644580)
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  • 7.  SAKATANI Takashi
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  • 8.  和田 龍一
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