Kono Hajime 河野肇

… Alternative Names

KONO Hajime 河野肇

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Researcher Number	60585074
Other IDs
Affiliation (Current)	2025: 帝京大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 帝京大学, 医学部, 教授 2011 – 2016: 帝京大学, 医学部, 准教授 2012: 帝京大学, 医学部, 講師 2010: 帝京大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / 膠原病・アレルギー・感染症内科学 / Cardiovascular medicine / Collagenous pathology/Allergology / Biological Sciences Except Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 52040:Radiological sciences-related / Basic Section 49030:Experimental pathology-related / Collagenous pathology/Allergology / 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator 自然炎症 / インフラマソーム / IL-1 / 動脈硬化 / TLR / HDL / 炎症 / 細胞死 / 好中球 / ミトコンドリア … More / NETs / ヒドロキシクロロキン / 全身性エリテマトーデス / SLE / mTOR / ミトコンドリア活性酸素 / HIF-1α / AMPK / 尿酸 / ATF3 / NLRP3 / リウマチ学 / sykキナーゼ / 自然免疫 / 結晶 / Caspase 1 / Cathepsin C / Clec9a / Cタイプレクチン … More Except Principal Investigator 全身性エリテマトーデス / 関節リウマチ / 遺伝子多型 / MRI / 遺伝子 / SNV / バリアント / ロングリードシークエンス / NCF2 / NCF1 / NOX2複合体 / 疾患感受性遺伝子 / IVIG療法 / Vasculitis / CAWS / 血管炎症候群 / VasSF / Apolipoprotein A-II / 川崎病 / 構造計算 / タンパク質間結合 / 細胞膜貫通部位 / 免疫創薬標的 / 創薬標的 / 自己免疫疾患 / 膜貫通ドメイン / シグナル伝達 / 免疫抑制シグナル / 免疫グロブリンFc受容体 / membrane-spanning 4 / Fc gamma RIIa / Fc gamma RIIb / IgG Fc受容体 / 2量体 / 膜貫通部位 / Fc(gamma)RIIB / TMD4ファミリー / Fc受容体 / 炎症性メディエーター / Notch / ANCA関連血管炎 / 全身性強皮症 / NLRP3 / 膠原病学 Less

手関節リウマチにおける活動性滑膜炎の非造影MR灌流画像評価法の開発
- Principal Investigator
  
  山本麻子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Teikyo University
Significance of genomic diversity of NOX2 complex in onset and pathogenesis of systemic lupus erythematosus
- Principal Investigator
  
  Kawasaki Aya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  University of Tsukuba
Dissection of innate immune pathogenesis of SLE by identifying novel hydroxychloroquine's mode of actionPrincipal Investigator
- Principal Investigator
  
  KONO HAJIME
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Teikyo University
ヒトSｃFvライブラリーを用いた血管炎症候群に対する治療標的分子の同定と解析
- Principal Investigator
  
  伊藤吹夕
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Teikyo University
A novel functional antigen receptor TMD module identified as an SLE-associating SNP-related structure
- Principal Investigator
  
  Honda Zen-ichiro
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Ochanomizu University
Molecular mechanisms of uric acid for promoting atherosclerosisPrincipal Investigator
- Principal Investigator
  
  Kono Hajime
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Teikyo University
Innate immunity in the pathogenesis of rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  Hajime Kono
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Teikyo University
Ｎｏｔｃｈリガンド分子阻害による関節炎抑制機序の解明
- Principal Investigator
  
  関根知世子
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Teikyo University
The anti-inflammatory mechanism of HDL in atherosclerosisPrincipal Investigator
- Principal Investigator
  
  KONO Hajime
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Teikyo University
動脈硬化におけるチロシンキナーゼＳｙｋを介した自然免疫炎症の解明Principal Investigator
- Principal Investigator
  
  河野肇
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Teikyo University
The mechanism of innate inflammation in response to cell death and it's contribution to the pathogenesis of rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  KONO Hajime
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Teikyo University
A role of danger signal response gene NLRP3 for the genetic predisposition to systemic rheumatic diseases
- Principal Investigator
  
  TSUCHIYA Naoyuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  University of Tsukuba
細胞死を感知し炎症を惹起する分子機構の解明Principal Investigator
- Principal Investigator
  
  河野肇
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Teikyo University

All 2022 2019 2014 2012 2011 2010 Other

All Journal Article Presentation Other

[Journal Article] Decrease in MPO-ANCA after administration of benralizumab in eosinophilic granulomatosis with polyangiitis2019
- Author(s)
  Takenaka Kenchi、Minami Tomoko、Yoshihashi Yoko、Hirata Shinya、Kimura Yoshitaka、Kono Hajime
- Journal Title
  
  Allergol. Int.
  
  Volume: 68 Issue: 4 Pages: 539-540
- DOI
  10.1016/j.alit.2019.04.006
- NAID
  130007733090
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08418
[Journal Article] High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF32014
- Author(s)
  De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, Beyer M, Xu D, Zimmer S, Lahrmann C, Schildberg FA, Vogelhuber J, Kraut M, Ulas T, Kerksiek A, Krebs W, Bode N, Grebe A, Fitzgerald ML, Hernandez NJ, Williams BR, Knolle P, Kneilling M, Röcken M, Lütjohann D, Wright SD, Schultze JL, Latz E
- Journal Title
  
  Nat Immunol
  
  Volume: 15(2)(Epub 2013 Dec 8) Issue: 2 Pages: 152-60
- DOI
  10.1038/ni.2784
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591468, KAKENHI-PROJECT-26293235
[Journal Article] 関節リウマチとIL-72014
- Author(s)
  関根　知世子、河野　肇
- Journal Title
  
  リウマチ科
  
  Volume: 51 Pages: 438-443
- Data Source
  KAKENHI-PROJECT-26461475
[Journal Article] The IL-1-dependent sterile inflammatory response has a substantial caspase-1-independent component that requires cathepsin C2012
- Author(s)
  Kono H, Orlowski GM, Patel Z, Rock KL
- Journal Title
  
  J Immunol
  
  Volume: 189(7)(Epub 2012 Aug 22) Pages: 3734-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591468
[Journal Article] 動脈硬化と自然免疫2012
- Author(s)
  河野肇
- Journal Title
  
  Annual Reviews循環器2012
  
  Volume: 2012 Pages: 42-48
- Data Source
  KAKENHI-PROJECT-23591468
[Journal Article] NLRPインフラマソームと動脈硬化2011
- Author(s)
  河野肇
- Journal Title
  
  呼吸と循環
  
  Volume: 59 Pages: 873-882
- Data Source
  KAKENHI-PROJECT-23591468
[Journal Article] Innate and adaptive immune reponses to cell death.2011
- Author(s)
  Rock KL, Lai JJ, Kono H
- Journal Title
  
  Immunol Rev
  
  Volume: 243 Pages: 191-205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591468
[Journal Article] Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death.2010
- Author(s)
  Hajime Kono
- Journal Title
  
  J Immunol
  
  Volume: 184 Pages: 4470-4478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890197
[Journal Article] NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals2010
- Author(s)
  Hajime Kono
- Journal Title
  
  Nature
  
  Volume: 464 Pages: 1357-1361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890197
[Journal Article] Uric acid promotes an acute inflammatory response to sterile cell death in mice.2010
- Author(s)
  Hajime Kono
- Journal Title
  
  J Clin Invest
  
  Volume: 120 Pages: 1939-1949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890197
[Presentation] カンジダ菌体抽出物（CAWS）による川崎病モデルマウスへの抗VAP2抗体投与の有効性2022
- Author(s)
  伊藤吹夕、津久井大輔、大原関利章、木村佳貴、柳田たみ子、岸フク子、山河芳夫、亀岡洋祐、鈴木章一、三浦典子、大野尚仁、高橋啓、河野肇、鈴木和男
- Organizer
  第3回　血管炎病因病態研究会
- Data Source
  KAKENHI-PROJECT-19K07489
[Presentation] カンジダ菌体抽出物（CAWS）誘導血管炎モデルマウスへの抗VAP2抗体投与の有効性2019
- Author(s)
  伊藤吹夕、津久井大輔、大原関利章、木村佳貴、柳田たみ子、岸フク子、山河芳夫、亀岡洋祐、鈴木章一、三浦典子、大野尚仁、高橋啓、河野肇、鈴木和男
- Organizer
  第25回　ＭＰＯ研究会
- Data Source
  KAKENHI-PROJECT-19K07489
[Presentation] NLRP3多型と全身性エリテマトーデスとの関連2012
- Author(s)
  青木真志、川崎綾、古川宏、近藤裕也、伊藤聡、林太智、草生真規雄、瀬戸口京吾、永井立夫、河野肇、松本功、廣畑俊成、當間重人、高崎芳成、橋本博史、住田孝之、土屋尚之
- Organizer
  第56回日本リウマチ学会総会・学術集会
- Place of Presentation
  グランドプリンスホテル新高輪、東京
- Year and Date
  2012-04-27
- Data Source
  KAKENHI-PROJECT-23659495
[Presentation] BEYOND THE INFLAMMASOME: ROLE OF DIPEPTIDYL PEPTIDASE I (CATEPSIN C) IN THE MATURATION OF IL-1Β IN VIVO2011
- Author(s)
  Hajime Kono
- Organizer
  Annual European Congress of Rheumatology EULAR 2011
- Place of Presentation
  London, UK
- Data Source
  KAKENHI-PROJECT-23591468
[Presentation] The IL-1-dependent sterile inflammatory response has asubstantial caspase-1-independent domponent that requires cathepsin C
- Author(s)
  H. Kono, G. Orlowski, Z. Patel, K. L. Rock
- Organizer
  IEIIS
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PUBLICLY-24117719
[Presentation] Anti-inflammatory Property of HDL in NOD1 Ligand induced Kawasaki Arteritis in Mice
- Author(s)
  H. Kono, T. Yanagida, H. Kikuchi, K. Asako
- Organizer
  American college of Rheumatology
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PUBLICLY-24117719
[Presentation] Reconstituted HDL Ameliorates NOD1 Ligand Induced Kawasaki Arteritis in Mice
- Author(s)
  H. Kono,T. Yanagida, H. Kikuchi, K. Asako
- Organizer
  EULAR
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PUBLICLY-24117719
[Presentation] The IL-1-dependent sterile inflammatory response has a substantial caspase-1- independent domponent that requires cathepsin C
- Author(s)
  H. Kono, G. Orlowski, Z .Patel, K. L. Rock
- Organizer
  IEIIS 2012
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23591468
[Presentation] インフラマソーム非依存性IL-1β活性化による結晶誘発性急性炎症
- Author(s)
  河野　肇、柳田　たみ子、浅子　来美、高山　真希、菊地　弘敏
- Organizer
  第57回日本リウマチ学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591468
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1. NANKI Toshihiro (00282749)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. Honda Zen-ichiro (70238814)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 関根知世子 (40392005)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. 本田浩章 (40245064)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TSUCHIYA Naoyuki (60231437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. FURUKAWA Hiroshi (00372293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. Kawasaki Aya (30532816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 由良敬 (50252226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 市育代 (50403316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 伊藤吹夕 (20415079)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 大原関利章 (20287501)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 山本麻子 (70797125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 林達也 (60781549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 小島慎也 (70815670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 西村慶太 (80198499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SEKI Reiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. YANAGIDA Tamiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kono Hajime 河野 肇

KONO Hajime 河野 肇

Research Projects

Research Products

Co-Researchers

手関節リウマチにおける活動性滑膜炎の非造影MR灌流画像評価法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Significance of genomic diversity of NOX2 complex in onset and pathogenesis of systemic lupus erythematosus

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Dissection of innate immune pathogenesis of SLE by identifying novel hydroxychloroquine's mode of actionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒトSｃFvライブラリーを用いた血管炎症候群に対する治療標的分子の同定と解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel functional antigen receptor TMD module identified as an SLE-associating SNP-related structure

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms of uric acid for promoting atherosclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Innate immunity in the pathogenesis of rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ｎｏｔｃｈリガンド分子阻害による関節炎抑制機序の解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The anti-inflammatory mechanism of HDL in atherosclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

動脈硬化におけるチロシンキナーゼＳｙｋを介した自然免疫炎症の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanism of innate inflammation in response to cell death and it's contribution to the pathogenesis of rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A role of danger signal response gene NLRP3 for the genetic predisposition to systemic rheumatic diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞死を感知し炎症を惹起する分子機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Kono Hajime 河野肇

KONO Hajime 河野肇

[Presentation] カンジダ菌体抽出物（CAWS）誘導血管炎モデルマウスへの抗VAP2抗体投与の有効性2019