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Tsukiyama Tomoyuki  築山 智之

… Alternative Names

TSUKIYAMA Tomoyuki  築山 智之

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Researcher Number 60612132
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-2657-7719
Affiliation (Current) 2025: 滋賀医科大学, 動物生命科学研究センター, 特任准教授
Affiliation (based on the past Project Information) *help 2019 – 2025: 滋賀医科大学, 動物生命科学研究センター, 特任准教授
2014 – 2018: 滋賀医科大学, 動物生命科学研究センター, 助教
2013: 独立行政法人理化学研究所, 発生・再生科学総合研究センター, 研究員
Review Section/Research Field
Principal Investigator
Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Basic Section 42030:Animal life science-related / General medical chemistry / Transformative Research Areas, Section (III) / Integrative animal science
Except Principal Investigator
Basic Section 53040:Nephrology-related / Basic Section 42030:Animal life science-related / Broad Section I / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Broad Section G / Biological Sciences / Basic Section 42040:Laboratory animal science-related
Keywords
Principal Investigator
カニクイザル / ゲノム編集 / 遺伝子改変 / ノックイン / iPS細胞 / CRISPR/Cas9 / ES細胞 / 多能性幹細胞 / 霊長類 / ナイーブ化 … More / トランスジェニック動物 / piggyBac / トランスポゾン / TS細胞 / ラットiPS細胞 / INTPS細胞 / 新型多能性幹細胞 / 異種間キメラ … More
Except Principal Investigator
霊長類 / 動物モデル / 栄養外胚葉 / 羊膜外胚葉 / 胚体外組織 / ヒトES細胞 / fMRI / 意思決定 / ドパミン / 可塑性 / 機能回復 / 遺伝子発現解析 / 精神疾患 / 依存症 / 脊髄損傷 / 急性腎障害 / シングルセル / 線維芽細胞 / エリスロポエチン / 老化関連T細胞 / シングルセル解析 / 亜集団 / 三次リンパ組織 / 細胞老化 / 慢性腎臓病 / リプログラミング / トロホブラスト / 種差 / トポロジー / ロバストネス / 自己組織化 / 哺乳類初期発生 / 発生生物学 / マウス / 減数分裂 / 試験管内再構成 / 発生 / ヒト / 進化 / 発現制御 / ゲノム / 再生医学 / 発生・分化 / ヒト発生生物学 / 試験管内誘導 / 卵母細胞 / エピゲノムリプログラミング / iPS細胞 / 生殖細胞 / ゲノム編集 / 霊長類モデル / 早期老化症候群 Less
  • Research Projects

    (17 results)
  • Research Products

    (61 results)
  • Co-Researchers

    (25 People)
  •  モザイク性の解消による早期表現型解析のための遺伝子改変技術基盤の構築Principal Investigator

    • Principal Investigator
      築山 智之
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42030:Animal life science-related
    • Research Institution
      Shiga University of Medical Science
  •  能動的組換えによる革新的遺伝子ノックインPrincipal Investigator

    • Principal Investigator
      築山 智之
    • Project Period (FY)
      2024 – 2025
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 42:Veterinary medical science, animal science, and related fields
    • Research Institution
      Shiga University of Medical Science
  •  Partial reprogramming of trophoblast stem cells to improve placental function

    • Principal Investigator
      高島 康弘
    • Project Period (FY)
      2023 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Kyoto University
  •  Primate Nephrology: analyzing primate-specific repair mechanisms of renal injury

    • Principal Investigator
      柳田 素子
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Kyoto University
  •  Development of innovative knock-in technology by active gene transferPrincipal Investigator

    • Principal Investigator
      TSUKIYAMA Tomoyuki
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 42:Veterinary medical science, animal science, and related fields
    • Research Institution
      Shiga University of Medical Science
  •  Elucidating the pathogenesis of and development of therapeutic strategies against the neuropsychiatric disorders in the primate models by utilizing the gene introduction and manipulation technologies

    • Principal Investigator
      伊佐 正
    • Project Period (FY)
      2022 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section I
    • Research Institution
      Kyoto University
  •  遺伝子改変動物作出におけるモザイク性の解消Principal Investigator

    • Principal Investigator
      築山 智之
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42030:Animal life science-related
    • Research Institution
      Shiga University of Medical Science
  •  幹細胞を用いた羊膜前駆細胞の発生機序と細胞特性解析

    • Principal Investigator
      大串 雅俊
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42030:Animal life science-related
    • Research Institution
      Kyoto University
  •  Spatio-temporal variabilities and robustness in pre-implantation mammalian development

    • Principal Investigator
      柊 卓志
    • Project Period (FY)
      2021 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section G
    • Research Institution
      Kyoto University
  •  Development of innovative knock-in technology using endogenous homologous recombination mechanismPrincipal Investigator

    • Principal Investigator
      TSUKIYAMA Tomoyuki
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 42:Veterinary medical science, animal science, and related fields
    • Research Institution
      Shiga University of Medical Science
  •  Establishment of a technology platform for genetic modification of fertilized eggs that enables analysis from the F0 generationPrincipal Investigator

    • Principal Investigator
      Tsukiyama Tomoyuki
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      Shiga University of Medical Science
  •  Cellular senescence of renal "subpopulations" influences renal aging and injury responsiveness

    • Principal Investigator
      Yanagita Motoko
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Kyoto University
  •  Development of diagnosis and therapy for aging using a nonhuman primate model of premature aging

    • Principal Investigator
      Itoh Yasushi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 42040:Laboratory animal science-related
    • Research Institution
      Shiga University of Medical Science
  •  Establishment of high-quality novel ES / iPS cells that precisely reflect the in vivo statePrincipal Investigator

    • Principal Investigator
      TSUKIYAMA Tomoyuki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Integrative animal science
    • Research Institution
      Shiga University of Medical Science
  •  Mechanism and Reconstitution In Vitro of Human Germ Cell Development

    • Principal Investigator
      Saitou Mitinori
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Establishment of novel pluripotent stem cells using genetically modified cynomolgus ES and iPS cells.Principal Investigator

    • Principal Investigator
      TSUKIYAMA Tomoyuki
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Shiga University of Medical Science
  •  Establishment of novel pluripotent stem cells in mammals by iPS technology.Principal Investigator

    • Principal Investigator
      TSUKIYAMA Tomoyuki
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Shiga University of Medical Science
      Institute of Physical and Chemical Research

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013

All Journal Article Presentation Book

  • [Book] 実験医学別冊 マウス表現型解析スタンダード2016

    • Author(s)
      築山 智之、依馬 正次
    • Total Pages
      347
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-15K21080
  • [Journal Article] Null mutation of exocyst complex component 3-like does not affect vascular development in mice2024

    • Author(s)
      Takashima Satsuki、Okamura Eiichi、Ichiyama Yusuke、Nishi Kiyoto、Shimizu Akio、Watanabe Chisato、Muto Masanaga、Matsumoto Shoma、Tsukiyama-Fujii Setsuko、Tsukiyama Tomoyuki、Ogita Hisakazu、Nishi Eiichiro、Ohji Masahito、Sugiyama Fumihiro、Takahashi Satoru、Mizuno Seiya、Mizutani Ken-ichi、Ema Masatsugu
    • Journal Title

      Exp. Anim.

      Volume: 73 Issue: 1 Pages: 93-100

    • DOI

      10.1538/expanim.23-0105

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23KJ1146, KAKENHI-PROJECT-23K07966, KAKENHI-PROJECT-23K08732, KAKENHI-PROJECT-21K06854, KAKENHI-PROJECT-22K19246, KAKENHI-PROJECT-22K19428, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-23K23794
  • [Journal Article] Temporal variability and cell mechanics control robustness in mammalian embryogenesis2023

    • Author(s)
      Fabreges, D., Corominas Murtra, B., Moghe, P., Kickuth, A., Ichikawa, T., Iwatani, C., Tsukiyama, T., Daniel, N., Gering, J., Stokkermans, A., Wolny, A., Kreshuk, A., Duranthon, V., Uhlmann, V., Hannezo, E. and Hiiragi, T
    • Journal Title

      bioRxiv

      Volume: NA

    • DOI

      10.1101/2023.01.24.525420

    • Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H05038
  • [Journal Article] Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys2023

    • Author(s)
      Gyobu‐Motani Sayuri、Yabuta Yukihiro、Mizuta Ken、Katou Yoshitaka、Okamoto Ikuhiro、Kawasaki Masanori、Kitamura Ayaka、Tsukiyama Tomoyuki、Iwatani Chizuru、Tsuchiya Hideaki、Tsujimura Taro、Yamamoto Takuya、Nakamura Tomonori、Saitou Mitinori
    • Journal Title

      The EMBO Journal

      Volume: - Issue: 9

    • DOI

      10.15252/embj.2022112962

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19246, KAKENHI-PROJECT-22K15380, KAKENHI-ORGANIZER-20H05760, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-23K23794, KAKENHI-PROJECT-23K23804, KAKENHI-PROJECT-21K20740, KAKENHI-PROJECT-17H06098
  • [Journal Article] Generation of a familial hypercholesterolemia model in non-human primate2023

    • Author(s)
      Sato Akira、Tsukiyama Tomoyuki、Komeno Masahiro、Iwatani Chizuru、Tsuchiya Hideaki、Kawamoto Ikuo、Murase Mitsuru、Nakagawa Takahiro、Itagaki Iori、Seita Yasunari、Matsumoto Shoma、Nakaya Masataka、Shimizu Akio、Yamada Atsushi、Ema Masatsugu、Ogita Hisakazu
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 15649-15649

    • DOI

      10.1038/s41598-023-42763-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K08732, KAKENHI-PROJECT-21K06854, KAKENHI-PROJECT-21K09419, KAKENHI-PROJECT-22K19246, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-23K23794
  • [Journal Article] <i>Ex vivo</i> reconstitution of fetal oocyte development in humans and cynomolgus monkeys2022

    • Author(s)
      Mizuta Ken、Katou Yoshitaka、Nakakita Baku、Kishine Aoi、Nosaka Yoshiaki、Saito Saki、Iwatani Chizuru、Tsuchiya Hideaki、Kawamoto Ikuo、Nakaya Masataka、Tsukiyama Tomoyuki、Nagano Masahiro、Kojima Yoji、Nakamura Tomonori、Yabuta Yukihiro、Horie Akihito、Mandai Masaki、Ohta Hiroshi、Saitou Mitinori
    • Journal Title

      The EMBO Journal

      Volume: 41 Issue: 18

    • DOI

      10.15252/embj.2022110815

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06066, KAKENHI-PROJECT-22K19246, KAKENHI-ORGANIZER-20H05760, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-19H03618, KAKENHI-PROJECT-20K21500, KAKENHI-PROJECT-19K16023, KAKENHI-PROJECT-23K23794, KAKENHI-PROJECT-21K20740
  • [Journal Article] Essential Roles of Exocyst Complex Component 3-like 2 on Cardiovascular Development in Mice2022

    • Author(s)
      Watanabe C., Shibuya H., Ichiyama Y., Okamura E., Tsukiyama-Fujii S., Tsukiyama T., Matsushita J., Azami T., Kubota Y., Ohji M., Sugiyama F., Takahashi S., Mizuno S., Tamura M., Mizutani K. & Ema M.
    • Journal Title

      Life

      Volume: 12 Issue: 11 Pages: 1730-1730

    • DOI

      10.3390/life12111730

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06802, KAKENHI-PROJECT-22K19246, KAKENHI-ORGANIZER-20H05760, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-21J15321, KAKENHI-PROJECT-23K23794
  • [Journal Article] Conformational change of RNA-helicase DHX30 by ALS/FTD-linked FUS induces mitochondrial dysfunction and cytosolic aggregates2022

    • Author(s)
      Hikiami R, Morimura T, Ayaki T, Tsukiyama T, Morimura N, Kusui M, Wada H, Minamiyama S, Shodai A, Asada-Utsugi M, Muramatsu SI, Ueki T, Takahashi R, Urushitani M.
    • Journal Title

      Scxeintific Reports

      Volume: 12 Issue: 1 Pages: 16030-16046

    • DOI

      10.1038/s41598-022-20405-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K06391, KAKENHI-PROJECT-22K06429, KAKENHI-PROJECT-22K19246, KAKENHI-ORGANIZER-20H05760, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-23K23794, KAKENHI-PROJECT-23K24211
  • [Journal Article] Non-human primates as a model for human development2021

    • Author(s)
      Nakamura Tomonori、Fujiwara Kohei、Saitou Mitinori、Tsukiyama Tomoyuki
    • Journal Title

      Stem Cell Reports

      Volume: 16 Issue: 5 Pages: 1093-1103

    • DOI

      10.1016/j.stemcr.2021.03.021

    • NAID

      120007037861

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21370, KAKENHI-PLANNED-20H05763
  • [Journal Article] Chromosomal-scale de novo genome assemblies of Cynomolgus Macaque and Common Marmoset2021

    • Author(s)
      Jayakumar Vasanthan、Nishimura Osamu、Kadota Mitsutaka、Hirose Naoki、Sano Hiromi、Murakawa Yasuhiro、Yamamoto Yumiko、Nakaya Masataka、Tsukiyama Tomoyuki、Seita Yasunari、Nakamura Shinichiro、Kawai Jun、Sasaki Erika、Ema Masatsugu、Kuraku Shigehiro、Kawaji Hideya、Sakakibara Yasubumi
    • Journal Title

      Scientific Data

      Volume: 8 Issue: 1 Pages: 59-59

    • DOI

      10.1038/s41597-021-00935-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21370, KAKENHI-PROJECT-20K21407, KAKENHI-PLANNED-17H06410, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-18H04127, KAKENHI-PROJECT-19K16023, KAKENHI-PROJECT-20KK0186
  • [Journal Article] GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program2021

    • Author(s)
      Kojima Yoji、Yamashiro Chika、Murase Yusuke、Yabuta Yukihiro、Okamoto Ikuhiro、Iwatani Chizuru、Tsuchiya Hideaki、Nakaya Masataka、Tsukiyama Tomoyuki、Nakamura Tomonori、Yamamoto Takuya、Saitou Mitinori
    • Journal Title

      Life Science Alliance

      Volume: 4 Issue: 5 Pages: 202000974-202000974

    • DOI

      10.26508/lsa.202000974

    • NAID

      120006979739

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21370, KAKENHI-PROJECT-19K16023, KAKENHI-ORGANIZER-20H05760, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-18K06030, KAKENHI-PROJECT-17H06098, KAKENHI-PLANNED-20H05761, KAKENHI-PROJECT-18K14714, KAKENHI-PROJECT-20K06654
  • [Journal Article] Induction of the germ cell fate from pluripotent stem cells in cynomolgus monkeys.2020

    • Author(s)
      Sakai Y, Nakamura T, Okamoto I, Gyobu-Motani S, Ohta H, Yabuta Y, Tsukiyama T, Iwatani C, Tsuchiya H, Ema M, Morizane A, Takahashi J, Yamamoto T, Saitou M.
    • Journal Title

      Biol Reprod

      Volume: 102(3) Issue: 3 Pages: 620-638

    • DOI

      10.1093/biolre/ioz205

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06030, KAKENHI-PROJECT-19K16013, KAKENHI-PROJECT-19H03618, KAKENHI-PROJECT-17K08135, KAKENHI-PROJECT-18K14714, KAKENHI-PROJECT-17H06098
  • [Journal Article] Generation of transgenic cynomolgus monkeys overexpressing the gene for amyloid-β precursor protein2020

    • Author(s)
      Seita Y, Morimura T, Watanabe N, Iwatani C, Tsuchiya H, Nakamura S, Suzuki T, Yanagisawa D, Tsukiyama T, Nakaya M, Okamura E, Muto M, Ema M, Nishimura M, Tooyama I.
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: - Issue: 1 Pages: 45-60

    • DOI

      10.3233/jad-191081

    • NAID

      120006859791

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K21585, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17K08077, KAKENHI-PROJECT-17K08135, KAKENHI-PROJECT-17K17812, KAKENHI-PROJECT-20K21370, KAKENHI-PROJECT-19K16023, KAKENHI-PROJECT-20K16491, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-18H02566
  • [Journal Article] Generation of an OCT3/4 reporter cynomolgus monkey ES cell line using CRISPR/Cas9.2019

    • Author(s)
      Kobayashi K, Tsukiyama T, Nakaya M, Kageyama S, Tomita K, Murai R, Yoshida T, Narita M, Kawauchi A, Ema M.
    • Journal Title

      Stem cell research

      Volume: Epub Pages: 101439-101439

    • DOI

      10.1016/j.scr.2019.101439

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K20131, KAKENHI-PROJECT-17H06766, KAKENHI-PROJECT-18K09192, KAKENHI-PROJECT-17K08135
  • [Journal Article] Generating Vegfr3 reporter transgenic mouse expressing membrane-tagged Venus for visualization of VEGFR3 expression in vascular and lymphatic endothelial cells2019

    • Author(s)
      Watanabe C., Matsushita J., Azami T., Tsukiyama-Fujii S., Tsukiyama T., Mizuno S., Takahashi S., and Ema M.
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 1 Pages: e0210060-e0210060

    • DOI

      10.1371/journal.pone.0210060

    • NAID

      120007128325

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08135, KAKENHI-PROJECT-18H02363
  • [Journal Article] Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease2019

    • Author(s)
      Tsukiyama T, Kobayashi K, Nakaya M, Iwatani C, Seita Y, Tsuchiya H, Matsushita J, Kitajima K, Kawamoto I, Nakagawa T, Fukuda K, Iwakiri T, Izumi H, Itagaki I, Kume S, Maegawa H, Nishinakamura R, Nishio, Nakamura S, Kawauchi A, Ema M
    • Journal Title

      Nature Communications

      Volume: 10 (1) Issue: 1 Pages: 5517-5517

    • DOI

      10.1038/s41467-019-13398-6

    • NAID

      120006773159

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K22363, KAKENHI-PROJECT-19K16023, KAKENHI-PROJECT-17K08135, KAKENHI-PROJECT-17K09679, KAKENHI-PROJECT-16K20131
  • [Journal Article] Comprehensive evaluation of ubiquitous promoters suitable for the generation of transgenic cynomolgus monkeys†2019

    • Author(s)
      Seita Yasunari、Tsukiyama Tomoyuki、Azami Takuya、Kobayashi Kenichi、Iwatani Chizuru、Tsuchiya Hideaki、Nakaya Masataka、Tanabe Hideyuki、Hitoshi Seiji、Miyoshi Hiroyuki、Nakamura Shinichiro、Kawauchi Akihiro、Ema Masatsugu
    • Journal Title

      Biology of Reproduction

      Volume: 印刷中 Issue: 6 Pages: 1440-1452

    • DOI

      10.1093/biolre/ioz040

    • NAID

      120006594188

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H06766, KAKENHI-PROJECT-16K14578, KAKENHI-PROJECT-17K14977, KAKENHI-PROJECT-17K08135, KAKENHI-PROJECT-16K20131, KAKENHI-PROJECT-16H04671
  • [Journal Article] Flexible adaptation of male germ cells from female iPSCs of endangered Tokudaia osimensis2017

    • Author(s)
      Arata Honda, Narantsog Choijookhuu, Haruna Izu, Yoshihiro Kawano, Mizuho Inokuchi, Kimiko Honsho, Ah-Reum Lee, Hiroki Nabekura, Hiroshi Ohta, Tomoyuki Tsukiyama, Yasuhide Ohinata, Asato Kuroiwa, Yoshitaka Hishikawa, Mitinori Saitou, Takamichi Jogahara, Chihiro Koshimoto
    • Journal Title

      Science Advances

      Volume: - Issue: 5

    • DOI

      10.1126/sciadv.1602179

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25712030, KAKENHI-PROJECT-16K08471, KAKENHI-PROJECT-17K08135, KAKENHI-PROJECT-26430092, KAKENHI-PROJECT-15H04286, KAKENHI-PROJECT-15K14887, KAKENHI-PROJECT-17H06098
  • [Journal Article] Flexible adaptation of male germ cells from female iPS cells of endangered Tokudaia osimensis2017

    • Author(s)
      Honda A., Choijookhuu N., Izu H., Kawano Y., Inokuchi M., Honsho K., Lee A., Nabekura H., Ohta H., Tsukiyama T., Ohinata Y., Kuroiwa A., Hishikawa Y., Saitou M., Jogahara T., Koshimoto C.
    • Journal Title

      Science Advances

      Volume: 印刷中

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K21080
  • [Journal Article] Derivation of Induced Trophoblast Cell Lines in Cattle by Doxycycline-Inducible piggyBac Vectors2016

    • Author(s)
      Kawaguchi T, Cho D, Hayashi M, Tsukiyama T, Kimura K, Matsuyama S, Minami N, Yamada M and Imai H
    • Journal Title

      PloS One

      Volume: 11 Issue: 12 Pages: 1-15

    • DOI

      10.1371/journal.pone.0167550

    • NAID

      120005980901

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05042, KAKENHI-PROJECT-26292168, KAKENHI-PROJECT-15K21080
  • [Journal Article] Visualization of the Epiblast 1 and Visceral Endodermal Cells using Fgf5-P2A-Venus BAC Transgenic Mice and Epiblast Stem Cells2016

    • Author(s)
      Khoa LTP, Azami T, Tsukiyama T, Matsushita J, Tsukiyama-Fujii S, Takahashi S, Ema M.
    • Journal Title

      PLoS One.

      Volume: 16(1) Issue: 7 Pages: 310-310

    • DOI

      10.1371/journal.pone.0159246

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26221004, KAKENHI-PROJECT-15K21080
  • [Journal Article] Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body2016

    • Author(s)
      Seita Y, Tsukiyama T, Iwatani C, Tsuchiya H, Matsushita J, Azami T, Okahara J, Nakamura S, Hayashi Y, Hitoshi S, Itoh Y, Imamura T, Nishimura M, Tooyama I, Miyoshi H, Saitou M, Ogasawara K, Sasaki E, Ema M
    • Journal Title

      Scientific Reports

      Volume: 2 Issue: 1 Pages: 24868-24868

    • DOI

      10.1038/srep24868

    • NAID

      130007023590

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26640053, KAKENHI-PROJECT-15K21080, KAKENHI-PROJECT-16H04671, KAKENHI-PROJECT-26430070, KAKENHI-PROJECT-26870282, KAKENHI-PROJECT-16K14578
  • [Journal Article] A hyperactive <i>piggyBac</i> transposon system is an easy-to-implement method for introducing foreign genes into mouse preimplantation embryos2015

    • Author(s)
      Suzuki S, Tsukiyama T, Kaneko T, Imai S, Minami N.
    • Journal Title

      J. Reprod. Dev.

      Volume: 61 Issue: 3 Pages: 241-244

    • DOI

      10.1262/jrd.2014-157

    • NAID

      130005077740

    • ISSN
      0916-8818, 1348-4400
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23380164, KAKENHI-PROJECT-25871115
  • [Journal Article] Generation of naive bovine induced pluripotent stem cells using piggyBac transposition of doxycycline-inducible transcription factors2015

    • Author(s)
      Kawaguchi T., Tsukiyama T., Kimura K., Matsuyama S., Minami N., Yamada M. and Imai H.
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 8 Pages: e0135403-e0135403

    • DOI

      10.1371/journal.pone.0135403

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K21080, KAKENHI-PROJECT-24380172
  • [Journal Article] A modified EpiSC culture condition containing a GSK3 inhibitor can support germline-competent pluripotency in mice2014

    • Author(s)
      Tsukiyama T, Ohinata Y
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 4 Pages: e95329-e95329

    • DOI

      10.1371/journal.pone.0095329

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25712030, KAKENHI-PROJECT-25871115
  • [Journal Article] Establishment of trophoblast stem cells under defined culture conditions in mice2014

    • Author(s)
      Ohinata Y, Tsukiyama T
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 9 Pages: e107308-e107308

    • DOI

      10.1371/journal.pone.0107308

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25712030, KAKENHI-PROJECT-25871115
  • [Journal Article] A comprehensive system for generation and evaluation of induced pluripotent stem cells using piggyBac transposition2014

    • Author(s)
      Tsukiyama T, Kato-Itoh M, Nakauchi H, Ohinata Y
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 3 Pages: e92973-e92973

    • DOI

      10.1371/journal.pone.0092973

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25712030, KAKENHI-PROJECT-25871115
  • [Presentation] 遺伝子改変カニクイザルの作出2024

    • Author(s)
      築山 智之
    • Organizer
      革新脳分科会The Final
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19246
  • [Presentation] 遺伝子改変カニクイザルの作出2024

    • Author(s)
      築山 智之
    • Organizer
      革新脳分科会The Final
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K23794
  • [Presentation] Generating transgenic non-human primates via the piggyBac transposon system.2023

    • Author(s)
      Nakaya M. and Tsukiyama T.
    • Organizer
      日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-22K19246
  • [Presentation] NPHP1ノックアウトカニクイザルの作成による若年性ネフロン癆の病態再現2023

    • Author(s)
      鳥生直哉,中家雅隆,山田 龍,好川貴久,築山智之,柳田素子,伊佐 正
    • Organizer
      日本内科学会講演会
    • Data Source
      KAKENHI-PROJECT-23K27616
  • [Presentation] Generating transgenic non-human primates via the piggyBac transposon system.2023

    • Author(s)
      Nakaya M. and Tsukiyama T.
    • Organizer
      日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-23K23794
  • [Presentation] 遺伝子改変カニクイザルの作出2023

    • Author(s)
      築山 智之
    • Organizer
      日本受精着床学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K23794
  • [Presentation] piggyBacトランスポゾンシステムを介した非ヒト霊長類トランスジェニック動物の作出2023

    • Author(s)
      中家 雅隆, 築山 智之
    • Organizer
      日本繁殖生物学会
    • Data Source
      KAKENHI-PROJECT-23K23794
  • [Presentation] 遺伝子改変カニクイザルの作出2023

    • Author(s)
      築山 智之
    • Organizer
      日本受精着床学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19246
  • [Presentation] piggyBacトランスポゾンシステムを介した非ヒト霊長類トランスジェニック動物の作出2023

    • Author(s)
      中家 雅隆, 築山 智之
    • Organizer
      日本繁殖生物学会
    • Data Source
      KAKENHI-PROJECT-22K19246
  • [Presentation] NPHP1ノックアウトカニクイザルの作成による若年性ネフロン癆の病態再現2022

    • Author(s)
      鳥生直哉、中家雅隆、山田龍、好川貴久、岩谷千鶴、土屋英明、築山(藤井)勢津子、中川孝博、築山智之、柳田素子
    • Organizer
      第65回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-20H03697
  • [Presentation] piggyBacトランスポゾンシステムを利用したトランスジェニックカニクイザルの作出2022

    • Author(s)
      中家 雅隆, 築山 智之
    • Organizer
      日本繁殖生物学会
    • Data Source
      KAKENHI-PROJECT-23K23794
  • [Presentation] piggyBacトランスポゾンシステムを利用したトランスジェニックカニクイザルの作出2022

    • Author(s)
      中家 雅隆, 築山 智之
    • Organizer
      日本繁殖生物学会
    • Data Source
      KAKENHI-PROJECT-22K19246
  • [Presentation] piggyBacトランスポゾンシステムを利用したトランスジェニックカニクイザルの作出2022

    • Author(s)
      中家 雅隆, 築山 智之
    • Organizer
      日本繁殖生物学会
    • Data Source
      KAKENHI-PLANNED-20H05763
  • [Presentation] Generation of transgenic cynomolgus monkeys using piggyBac transposition.2021

    • Author(s)
      Tsukiyama T.
    • Organizer
      日本分子生物学会
    • Invited
    • Data Source
      KAKENHI-PLANNED-20H05763
  • [Presentation] Generation of transgenic cynomolgus monkeys using piggyBac transposition.2021

    • Author(s)
      Tsukiyama T.
    • Organizer
      日本分子生物学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K21370
  • [Presentation] CRISPR/Cas9を用いたカニクイザルにおける疾患モデリング2020

    • Author(s)
      築山 智之
    • Organizer
      日本マーモセット研究会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08135
  • [Presentation] Disease modeling in cynomolgus monkeys using CRISPR/Cas9.2020

    • Author(s)
      Tsukiyama T.
    • Organizer
      日本発生生物学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K21370
  • [Presentation] Disease modeling in cynomolgus monkeys using CRISPR/Cas9.2020

    • Author(s)
      Tsukiyama T.
    • Organizer
      日本発生生物学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08135
  • [Presentation] Disease modeling in cynomolgus monkeys using CRISPR/Cas9.2020

    • Author(s)
      Tsukiyama T.
    • Organizer
      日本発生生物学会
    • Invited
    • Data Source
      KAKENHI-PLANNED-20H05763
  • [Presentation] CRISPR/Cas9を用いた遺伝性腎疾患モデルカニクイザルの作出2018

    • Author(s)
      築山 智之, 小林 憲市, 中家 雅隆, 岩谷 千鶴, 土屋 英明, 清田 弥寿成, 松下 淳, 北嶋 郁, 河本 育士, 中川 孝博, 福田 浩司, 岩切 哲平, 和泉 博之, 板垣 伊織, 中村 紳一朗, 河内 明宏, 依馬 正次
    • Organizer
      日本分子生物学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08135
  • [Presentation] CRISPR/Cas9を用いたADPKDモデルカニクイザルの作出と解析2018

    • Author(s)
      依馬 正次, 築山 智之, 小林 憲市, 和泉 博之, 河内 明宏
    • Organizer
      日本腎臓学会東部学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08135
  • [Presentation] カニクイザルを用いた遺伝性腎疾患動物モデルの作製2018

    • Author(s)
      小林 憲市, 築山 智之, 影山 進, 岩谷 千鶴, 福田 浩司, 岩切 哲平, 和泉 博之,中村 紳一朗, 依馬 正次, 河内 明宏
    • Organizer
      日本泌尿器科学会
    • Data Source
      KAKENHI-PROJECT-17K08135
  • [Presentation] CRISPR/Cas9を用いた疾患モデルカニクイザルの作出2017

    • Author(s)
      築山 智之, 小林 憲市, 岩谷 千鶴, 土屋 英明, 清田 弥寿成, 松下 淳, 北嶋 郁, 河本 育士, 中川 孝博, 福田 浩司, 岩切 哲平, 和泉 博之, 板垣 伊織, 中村 紳一朗, 河内 明宏, 依馬 正次
    • Organizer
      生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-17K08135
  • [Presentation] CRISPR/Cas9を用いた疾患モデルカニクイザルの作出2017

    • Author(s)
      築山 智之
    • Organizer
      関西血管生物研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08135
  • [Presentation] Disease modeling in cynomolgus monkeys using CRISPR/Cas9 injection into ICSI embryos2017

    • Author(s)
      Tsukiyama T., Kobayashi K., Iwatani C., Tsuchiya H., Seita Y., Matsushita J., Kitajima K., Kawamoto I., Nakagawa T., Fukuda K., Iwakiri T., Izumi H., Itagaki I., Nakamura S., Kawauchi A. and Ema M.
    • Organizer
      4th World Congress of Reproductive Biology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08135
  • [Presentation] Generation of GFP transgenic cynomolgus monkeys2016

    • Author(s)
      Seita Y., Tsukiyama T., Iwatani C., Tsuchiya H., Matsushita J., Azami T., Ogasawara K. and Ema M.
    • Organizer
      SRF Annual Conference 2016
    • Place of Presentation
      University of Winchester
    • Year and Date
      2016-07-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K21080
  • [Presentation] 全身でGFPを発現するトランスジェニックカニクイザルの作製2016

    • Author(s)
      清田 弥寿成、築山 智之、岩谷 千鶴、松下 淳、土屋 英明、佐々木 えりか、依馬 正次
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      麻布大学
    • Year and Date
      2016-09-12
    • Data Source
      KAKENHI-PROJECT-15K21080
  • [Presentation] 全身でGFPを発現するトランスジェニックカニクイザルの作製2016

    • Author(s)
      清田 弥寿成、築山 智之、岩谷 千鶴、松下 淳、土屋 英明、浅見 拓哉、佐々木 えりか、依馬 正次
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15K21080
  • [Presentation] マウスおよびカニクイザル多能性幹細胞におけるCRISPR/Cas9を用いた発現増幅型多能性幹細胞レポーターのノックイン2015

    • Author(s)
      築山 智之、丹羽 仁史、岩谷 千鶴、土屋 英明、清田 弥寿成、松下 淳、依馬 正次
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      宮崎大学
    • Year and Date
      2015-09-19
    • Data Source
      KAKENHI-PROJECT-15K21080
  • [Presentation] ヒトおよびカニクイザル多能性幹細胞の培養におけるWnt阻害剤の影響2014

    • Author(s)
      築山 智之、岩谷 千鶴、土屋 英明、清田 弥寿成、松下 淳、依馬 正次
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      帯広畜産大学
    • Year and Date
      2014-08-23
    • Data Source
      KAKENHI-PROJECT-25871115
  • [Presentation] Germline contribution of rat iPS cells in mouse-rat interspecific chimeric animals.2014

    • Author(s)
      Ohinata Y. and Tsukiyama T.
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      帯広畜産大学
    • Year and Date
      2014-08-21
    • Data Source
      KAKENHI-PROJECT-25871115
  • [Presentation] piggyBacトランスポゾンを用いたリプログラミング因子導入によるウシ羊膜細胞からの栄養膜細胞株樹立の試み2014

    • Author(s)
      川口 高正、築山 智之、松山 秀一、木村 康二、南 直治郎、山田 雅保、今井 裕
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      帯広畜産大学
    • Year and Date
      2014-08-21
    • Data Source
      KAKENHI-PROJECT-25871115
  • [Presentation] piggyBacトランスポゾンを用いたナイーブ型ウシiPS細胞の樹立の試み2013

    • Author(s)
      川口 高正、築山 智之、南 直治郎、山田 雅保、松山 秀一、木村 康二、今井 裕
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      東京農工大学
    • Data Source
      KAKENHI-PROJECT-25871115
  • [Presentation] 蛍光レポーターによるPGC形成過程、精子形成過程、卵形成過程の可視化2013

    • Author(s)
      大日向 康秀、築山 智之
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      東京農工大学
    • Data Source
      KAKENHI-PROJECT-25871115
  • 1.  Yanagita Motoko (70378769)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 2.  Itoh Yasushi (90324566)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  Saitou Mitinori (80373306)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  依馬 正次 (60359578)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 5.  石垣 宏仁 (90432301)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  中村 紳一朗 (50307980)
    # of Collaborated Projects: 1 results
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  • 7.  柊 卓志 (00512477)
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    # of Collaborated Products: 1 results
  • 8.  高島 康弘 (70469930)
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    # of Collaborated Products: 0 results
  • 9.  伊佐 正 (20212805)
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    # of Collaborated Products: 0 results
  • 10.  太田 淳 (80304161)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  大串 雅俊 (00462664)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  TSUCHIYA Hideaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 13.  MIZUTANI Kenichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  小林 憲市
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  岡本 郁弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  中家 雅隆
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 17.  南 直治郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  大日向 康秀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 19.  高橋 智
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  扇田 久和
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  西村 正樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  漆谷 真
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  守村 敏史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  小笠原 一誠
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  佐々木 えりか
    # of Collaborated Projects: 0 results
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