NAGANO Hiromi 永野広海

Researcher Number	60613148
Other IDs	https://orcid.org/0000-0002-9080-7259
Affiliation (Current)	2026: 鹿児島大学, 医歯学域鹿児島大学病院, 講師
Affiliation (based on the past Project Information) *help	2020 – 2025: 鹿児島大学, 医歯学域鹿児島大学病院, 講師 2022: 鹿児島大学, 医歯学域医学系, 講師 2018 – 2019: 鹿児島大学, 医歯学域医学系, 講師 2015 – 2017: 鹿児島大学, 医歯学域医学系, 助教 2012 – 2014: 鹿児島大学, 医歯(薬)学総合研究科, 助教 2011 – 2012: 鹿児島大学, 大学院・医歯学総合研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology / Basic Section 52040:Radiological sciences-related
Keywords	Principal Investigator 粘膜免疫 / 粘膜免疫応答 / 特異的IgA / ホスホリルコリン / 経皮免疫 / 好酸球性副鼻腔炎 / 経鼻曝露 / 経鼻感作 / 経皮感作 / IgA … More / 鼻腔投与 / ワクチン / Poly(I:C) / PspA / streptococcus pneumoniae / 肺炎球菌 / 経鼻投与 / 鼻腔 / 経眼投与 / 感染症 / ﾏｲｸﾛニードル / 経皮ワクチン / コレラトキシン … More Except Principal Investigator 粘膜免疫 / 経鼻免疫 / 経鼻ワクチン / 粘膜ワクチン / ホスホリルコリン / 舌下免疫 / ワクチン / 肺炎球菌 / アレルギー / アレルギー性鼻炎 / 粘膜免疫応答 / 経皮免疫 / MRI / pH / CEST / 感染防御 / 免疫強化 / 分泌型IgA / マウス喉頭手術 / 気道粘膜再生 / 粘膜傷害抑制 / 喉頭気管粘膜 / 悪性腫瘍 / 感染 / 創傷治癒 / 上気道傷害 / 希少糖 / 創傷治癒促進 / 粘膜再生 / 上気道粘膜傷害 / P6 / PspA / 結合型ホスホリルコリン / 結合型ホスホリルコリ重合体（R-MPC） / 細菌接着性 / 結合型ホスホリルコリン重合体 / IgE / ハプテン作用 / アジュバント作用 / アジュバント / Th１/Th２型免疫応答 / 粘膜アジュバント / 広域スペクトラム / Th1/Th2型免疫応答 / ホスホリルコリン重合体 / Poly(I;C) / 上気道感染症 / Th17 / 自然免疫 / Poly(I:C) / 肺炎球菌ワクチン / PCV13 / 小児中耳炎 / 追加免疫 / 投与方法 / 注射ワクチン / 血小板活性化因子受容体 / ブースター効果 / 二相作用 / インフルエンザ菌 / 抗PC抗体 / バイオフィルム / 細菌接着 / 抗炎症作用 / IgA腎症 / PC-KLH / Phoshorylcholine(PC) / 特異的抗体価 / ｺﾚﾗﾄｷｼﾝ / ﾎｽﾎﾘﾙｺﾘﾝ / 特異的IgA / コレラトキシン Less

Epicutaneous Sensitization in BALB/c Mice Induces Stronger Systemic Th2 Inflammation than Intranasal Sensitization Despite Comparable Nasal EosinophiliaPrincipal Investigator
- Principal Investigator
  
  永野広海
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kagoshima University
Heterologous prime boost strategyを利用した粘膜免疫を誘導するワクチンの開発
- Principal Investigator
  
  大堀純一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kagoshima University
腫瘍内pH環境を画像化するpH-CESTの開発と頭頚部悪性腫瘍への応用
- Principal Investigator
  
  内匠浩二
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kagoshima University
Intranasolacrimal immunization for induction of secretory IgA responses in the respiratory tract.Principal Investigator
- Principal Investigator
  
  永野広海
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kagoshima University
Research for damage suppression and regenerative therapy in vocal fold mucosa
- Principal Investigator
  
  山下勝
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kagoshima University
Development of a wide-spectrum vaccine using a new mucosal adjuvant
- Principal Investigator
  
  Kurono Yuichi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kagoshima University
Toll様受容体リガンドを用いた自然免疫作動型感染症予防・治療薬開発に関する研究
- Principal Investigator
  
  馬越瑞夫
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Department of Clinical Research, National Hospital Organization Kagoshima Medical
  Kagoshima University
Development of nasal boost immunization with phosphorylcholine as a novel pneumococcal vaccination program
- Principal Investigator
  
  MASEDA Yoshiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kagoshima University
Transcutaneous immunization with phosphorylcholine induces antigen-specific mucosal and systemic immune responsesPrincipal Investigator
- Principal Investigator
  
  Nagano Hiromi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kagoshima University
Development of novel mucosal vaccine by applying the biphasic reaction of phosphorylcholine
- Principal Investigator
  
  Kurono Yuichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kagoshima University
Application of phosphorylcholine for multi-functional mucosal vaccine
- Principal Investigator
  
  KURONO YUICHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kagoshima University
Transcutaneous immunization with phosphorylcholine induces antigen-specific mucosal and systemic immune responses in BALB/c micePrincipal Investigator
- Principal Investigator
  
  NAGANO Hiromi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kagoshima University
Transcutaneous immunization induces antigen specific mucosal and syatemic immune responses in mice
- Principal Investigator
  
  MASEDA Yoshiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kagoshima University

All 2024 2023 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Intranasolacrimal Immunization of Mice with Pneumococcal Surface Protein A Plus Poly(I:C) Protective Against Nasopharyngeal Carriage of Streptococcus pneumonia2023
- Author(s)
  Hiromi Nagano, Issei Nagano, Masaki Kawabata, Junichiro Ohori and Yuichi Kurono
- Journal Title
  
  American Journal of Otolaryngology and Head and Neck Surgery
  
  Volume: 5 Pages: 1-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09669
[Journal Article] Intranasal immunization with phosphorylcholine suppresses allergic rhinitis in mice2018
- Author(s)
  Keiichi Miyashita,MD, Junichiro Ohori,MD,PhD, Hiromi Nagano, MD, Satoshi Fukuyama,MD, PhD, Yuichi Kurono, MD,PhD
- Journal Title
  
  The Laryngoscope
  
  Volume: 128(7) Issue: 7
- DOI
  10.1002/lary.27030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11239
[Journal Article] Mucosal and systemic immune response to sublingual or intranasal immunization with phosphorylcholine2018
- Author(s)
  Maseda Yoshiko、Ohori Junichiro、Tanaka Norimitsu、Nagano Hiromi、Miyashita Keiichi、Kurono Yuichi
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: 45 Issue: 2 Pages: 273-280
- DOI
  10.1016/j.anl.2017.04.009
- NAID
  130007589878
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11239
[Journal Article] Transcutaneous immunization in auricle skin induces antigen-specific mucosal and systemic immune responses in BALB/c mice2017
- Author(s)
  Nagano H., Jimura T., Nagano M., Miyashita K., Kurono Y.
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: 44 Issue: 4 Pages: 411-416
- DOI
  10.1016/j.anl.2016.08.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11238, KAKENHI-PROJECT-16K11239
[Journal Article] Transcutaneous immunization with phosphorylcholine induces antigen-specific mucosal and systemic immune responses in BALB/c mice.2015
- Author(s)
  Nagano H, Kurono Y,
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: 42(6) Pages: 478-482
- NAID
  130005125114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462689
[Journal Article] コレラトキシン経皮免疫による粘膜免疫応答2012
- Author(s)
  永野広海
- Journal Title
  
  日本口腔・咽頭科学会
  
  Volume: 25(1) Pages: 79-84
- NAID
  10030552707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] 臨床3T-MRIを用いた31P MRSおよびCESTイメージングによるpH評価のファントム研究2024
- Author(s)
  Koji Takumi, Hirokazu Otsuka, Takashi Iwanaga, Hiroto Hakamada, Hiroaki Nagano, Ryota Nakanosono, Jihun Kwon, Takashi Yoshiura
- Organizer
  第52回日本磁気共鳴医学会大会
- Data Source
  KAKENHI-PROJECT-24K10765
[Presentation] 13価肺炎球菌結合型ワクチン経鼻投与による免疫誘導2023
- Author(s)
  宮本　佑美、大堀　純一郎、川畠　雅樹、永野　広海、山下　勝
- Organizer
  第3回　日本耳鼻咽喉科免疫アレルギー感染症学会
- Data Source
  KAKENHI-PROJECT-22K09708
[Presentation] Transcutaneous immunization with pneumococcal surface protein A in mice2018
- Author(s)
  Hiromi Nagano
- Organizer
  The 17th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11238
[Presentation] PspA経皮ワクチンによる免疫応答の誘導2018
- Author(s)
  永野広海
- Organizer
  第１１９回日本耳鼻咽喉科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-16K11238
[Presentation] PspA点眼投与による上気道粘膜免疫応答の誘導2018
- Author(s)
  永野広海
- Organizer
  第３６回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-16K11238
[Presentation] PspA点眼投与による上気道粘膜免疫応答の誘導2017
- Author(s)
  永野広海
- Organizer
  第３０回日本口腔・咽頭科学会総会ならびに学術講演会
- Data Source
  KAKENHI-PROJECT-16K11238
[Presentation] 耳介経皮免疫によるホスホリルコリン特異的粘膜免疫応答の誘導2016
- Author(s)
  永野広海
- Organizer
  第１１７回日本耳鼻咽喉科学会通常総会・学術講演会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-16K11238
[Presentation] 耳介経皮免疫による粘膜免疫応答の誘導2015
- Author(s)
  永野広海
- Organizer
  第２５回日本耳科学会総会学術講演会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-10-07
- Data Source
  KAKENHI-PROJECT-25462689
[Presentation] CTおよびPC経皮免疫による粘膜免疫応答の経時的変化について2014
- Author(s)
  永野広海
- Organizer
  第３２回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  徳島市
- Data Source
  KAKENHI-PROJECT-25861572
[Presentation] CTおよびPC経皮免疫による粘膜免疫応答の経時的変化について2014
- Author(s)
  永野広海
- Organizer
  第３２回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  徳島市
- Data Source
  KAKENHI-PROJECT-25462689
[Presentation] コレラトキシン経皮免疫による粘膜免疫応答2013
- Author(s)
  永野広海
- Organizer
  第２６回日本口腔・咽頭科学会総会学術講演会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-25462689
[Presentation] コレラトキシン経皮免疫による粘膜免疫応答2013
- Author(s)
  永野広海
- Organizer
  第２６回日本口腔・咽頭科学会総会学術講演会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-25861572
[Presentation] PC経皮免疫による粘膜免疫応答の誘導2013
- Author(s)
  永野広海
- Organizer
  第１１４回日本耳鼻咽喉科学会総会・学術講演会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-25861572
[Presentation] PC経皮免疫による粘膜免疫応答の誘導2013
- Author(s)
  永野広海
- Organizer
  第１１４回日本耳鼻咽喉科学会総会・学術講演会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-25462689
[Presentation] PC経皮免疫による粘膜免疫応答の誘導2013
- Author(s)
  永野広海
- Organizer
  第３１回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  倉敷市
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] PC 経皮免疫による粘膜免疫応答の誘導2013
- Author(s)
  永野広海
- Organizer
  第31回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  倉敷
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] PC経皮免疫による粘膜免疫応答の誘導2012
- Author(s)
  永野広海
- Organizer
  第１０回日本ワクチン学会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] Transcutaneous immunization with cholera toxin in BALB/c mice2012
- Author(s)
  H.Nagano
- Organizer
  The 14th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] コレラトキシン経皮免疫による粘膜免疫応答の誘導2012
- Author(s)
  永野広海
- Organizer
  第30回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  大津市
- Year and Date
  2012-02-17
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] Transcutaneous immunization with cholera toxin in BALB/C mice.2012
- Author(s)
  H. Nagano
- Organizer
  he 14thJapan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] PC 経皮免疫による粘膜免疫応答の誘導2012
- Author(s)
  永野広海
- Organizer
  第10回日本ワクチン学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] Phosphorylcholineを用いた経皮免疫について2011
- Author(s)
  永野広海
- Organizer
  第26回九州連合地方部会学術講演会
- Place of Presentation
  久留米市
- Year and Date
  2011-07-10
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] コレラトキシン経皮免疫による口腔粘膜免疫応答の誘導2011
- Author(s)
  永野広海
- Organizer
  第24回日本口腔・咽頭科学会総会学術講演会
- Place of Presentation
  広島市
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] ヒアルロン酸マイクロニードルを用いた経皮免疫
- Author(s)
  永野広海
- Organizer
  第３３回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  東京（東武ホテルレバント東京）
- Year and Date
  2015-02-26 – 2015-02-28
- Data Source
  KAKENHI-PROJECT-25861572
[Presentation] ヒアルロン酸マイクロニードルを用いた経皮免疫
- Author(s)
  永野広海
- Organizer
  第33回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  東京(東武ホテルレバント東京)
- Year and Date
  2015-02-26 – 2015-02-28
- Data Source
  KAKENHI-PROJECT-25462689

1. MIYASHITA Keiichi (30585063)

# of Collaborated Projects: 8 results

# of Collaborated Products: 3 results
2. 大堀純一郎 (90507162)

# of Collaborated Projects: 8 results

# of Collaborated Products: 4 results
3. KURONO Yuichi (80153427)

# of Collaborated Projects: 7 results

# of Collaborated Products: 4 results
4. KAWABATA MASAKI (30585112)

# of Collaborated Projects: 7 results

# of Collaborated Products: 2 results
5. MAKISE Takao (30585120)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. 山下勝 (10635519)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
7. 田淵みな子 (90838187)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
8. MASEDA Yoshiko (70535666)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. 地村友宏 (10709596)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
10. 井内寛之 (90645285)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 宮之原郁代 (40305131)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. MATSUNE Shoji (00253899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 原田みずえ (20585103)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 馬越瑞夫 (30596325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 丸山征郎 (20082282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 大原章裕 (80784206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 内匠浩二 (50535820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 長野広明 (70778282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 中之薗良太 (00985088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 上村清央 (30593652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 岩永崇 (40444830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. 大塚洋和 (40973699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. 袴田裕人 (20727565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. 田畑和宏 (80419655)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 吉浦敬 (40322747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

NAGANO Hiromi 永野 広海

Research Projects

Research Products

Co-Researchers

Epicutaneous Sensitization in BALB/c Mice Induces Stronger Systemic Th2 Inflammation than Intranasal Sensitization Despite Comparable Nasal EosinophiliaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Intranasolacrimal immunization for induction of secretory IgA responses in the respiratory tract.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

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Transcutaneous immunization with phosphorylcholine induces antigen-specific mucosal and systemic immune responsesPrincipal Investigator

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Transcutaneous immunization with phosphorylcholine induces antigen-specific mucosal and systemic immune responses in BALB/c micePrincipal Investigator

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[Journal Article] Intranasolacrimal Immunization of Mice with Pneumococcal Surface Protein A Plus Poly(I:C) Protective Against Nasopharyngeal Carriage of Streptococcus pneumonia2023

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[Journal Article] Intranasal immunization with phosphorylcholine suppresses allergic rhinitis in mice2018

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NAGANO Hiromi 永野広海