Michinaga Shotaro 道永昌太郎

Researcher Number	60624054
Other IDs
Affiliation (Current)	2025: 明治薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 明治薬科大学, 薬学部, 講師 2015 – 2020: 大阪大谷大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Basic Section 47040:Pharmacology-related / Pharmacology in pharmacy Except Principal Investigator Basic Section 47040:Pharmacology-related / Pharmacology in pharmacy
Keywords	Principal Investigator アストロサイト / 脳浮腫 / 血液脳関門 / 頭部外傷 / ソニックヘッジホッグ / 外傷性脳損傷 / Blood-brain barrier / 薬理学 / ＥＴＢ受容体 / エンドセリン / アストログリア … More Except Principal Investigator … More ETB受容体 / 脳浮腫 / エンドセリン / 神経再生 / アストログリア / アストロサイト / 神経炎症 / neuroinflammation / brain edema / TBI / astroglia / endothelin / Eph/ephrinシグナル / ＥＴＢ受容体 Less

ソニックヘッジホッグ関連分子に着目した外傷性脳損傷に対する新規治療薬の創出Principal Investigator
- Principal Investigator
  
  道永昌太郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Meiji Pharmaceutical University
Development of therapeutic drugs for traumatic brain injury (TBI) to target astroglial endothelin receptors
- Principal Investigator
  
  Koyama Yutaka
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kobe Pharmaceutical University
Development of novel therapeutic drugs for traumatic brain injury focused on functional molecules in astrocytesPrincipal Investigator
- Principal Investigator
  
  Michinaga Shotaro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Meiji Pharmaceutical University
  Osaka Ohtani University
Development of novel astrocyte-targeted drugs against brain edema and neuronal injury
- Principal Investigator
  
  Koyama Yutaka
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kobe Pharmaceutical University
Exploration of novel anti-edema drugs by regulation of astroglial functionsPrincipal Investigator
- Principal Investigator
  
  Michinaga Shotaro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Osaka Ohtani University
Research and development of novel neuroprotective drugs targeting endothelin ETB receptor
- Principal Investigator
  
  Koyama Yutaka
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Kobe Pharmaceutical University
  Osaka Ohtani University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury (Rajendram et al. ed) 1st Edition, Chapter 182022
- Author(s)
  Shotaro Michinaga, Yutaka Koyama
- Total Pages
  594
- Publisher
  Elsevier
- ISBN
  9780128230367
- Data Source
  KAKENHI-PROJECT-21K06609
[Journal Article] Roles of astrocytic sonic hedgehog production and its signal for regulation of the blood-brain barrier permeability2024
- Author(s)
  Michinaga Shotaro、Hishinuma Shigeru、Koyama Yutaka
- Journal Title
  
  Vitamins and Hormones
  
  Volume: 126 Pages: 97-111
- DOI
  10.1016/bs.vh.2024.04.006
- ISBN
  9780443194047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06609
[Journal Article] Roles of Astrocytic Endothelin ETB Receptor in Traumatic Brain Injury2023
- Author(s)
  Michinaga Shotaro、Hishinuma Shigeru、Koyama Yutaka
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 5 Pages: 719-719
- DOI
  10.3390/cells12050719
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06609
[Journal Article] Selective histamine H2 receptor agonists alleviate blood-brain barrier disruption by promoting the expression of vascular protective factors following traumatic brain injury in mice2022
- Author(s)
  Shotaro Michinaga, Kiyomi Sonoda, Naoki Inazuki, Manae Ezaki, Hiroki Awane, Kahori Shimizu, Shigeru Hishinuma, Hiroyuki Mizuguchi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 150 Issue: 3 Pages: 135-145
- DOI
  10.1016/j.jphs.2022.08.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16016
[Journal Article] Pathophysiological Responses and Roles of Astrocytes in Traumatic Brain Injury2021
- Author(s)
  Michinaga Shotaro、Koyama Yutaka
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 12 Pages: 6418-6418
- DOI
  10.3390/ijms22126418
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06609, KAKENHI-PROJECT-20K16016
[Journal Article] Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 Reduces Vasogenic Edema after Traumatic Brain Injury in Mice2021
- Author(s)
  Shotaro Michinaga, Kazuya Onishi, Kahori Shimizu, Hiroyuki Mizuguchi, Shigeru Hishinuma
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 11 Pages: 1759-1766
- DOI
  10.1248/bpb.b21-00512
- NAID
  130008110320
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-11-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16016
[Journal Article] Down-regulation of astrocytic sonic hedgehog by activation of endothelin ETB receptors: Involvement in traumatic brain injury-induced disruption of blood brain barrier in a mouse model2021
- Author(s)
  Michinaga Shotaro、Inoue Ayana、Sonoda Kyomi、Mizuguchi Hiroyuki、Koyama Yutaka
- Journal Title
  
  Neurochemistry International
  
  Volume: 146 Pages: 105042-105042
- DOI
  10.1016/j.neuint.2021.105042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06695, KAKENHI-PROJECT-20K16016
[Journal Article] Endothelin receptor antagonists alleviate blood-brain barrier disruption and cerebral edema in a mouse model of traumatic brain injury: A comparison between bosentan and ambrisentan.2020
- Author(s)
  Michinaga Shotaro, Inoue Anna, Yamamoto Hayato, Ryu Ryotaro, Inoue Ayana, Mizuguchi Hiroyuki, Koyama Yutaka.
- Journal Title
  
  Neuropharmacology.
  
  Volume: 175 Pages: 108182-108182
- DOI
  10.1016/j.neuropharm.2020.108182
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16016, KAKENHI-PROJECT-18K06695
[Journal Article] Angiopoietin-1/Tie-2 signal after focal traumatic brain injury is potentiated by BQ788, an ETB receptor antagonist, in the mouse cerebrum: Involvement in recovery of blood-brain barrier function2020
- Author(s)
  Shotaro Michinaga, Ayami Tanabe, Ryusei Nakaya, Chihiro Fukutome, Anna Inoue, Aya Iwane, Yukiko Minato, Yu Tujiuchi, Daisuke Miyake, Hiroyuki Mizuguchi, Yutaka Koyama
- Journal Title
  
  Journal of Neurochemistry .
  
  Volume: Online ahead of print Issue: 3 Pages: 0-0
- DOI
  10.1111/jnc.14957
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06695, KAKENHI-PROJECT-20K16016
[Journal Article] Dual Roles of Astrocyte-Derived Factors in Regulation of Blood-Brain Barrier Function after Brain Damage2019
- Author(s)
  Michinaga Shotaro、Koyama Yutaka
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 3 Pages: 571-571
- DOI
  10.3390/ijms20030571
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06695, KAKENHI-PROJECT-16K18890
[Journal Article] Endothelin-1 stimulates expression of cyclin D1 and S-phase kinase?associated protein 2 by activating the transcription factor STAT3 in cultured rat astrocytes2019
- Author(s)
  Koyama Yutaka、Sumie Satoshi、Nakano Yasutaka、Nagao Tomoya、Tokumaru Shiho、Michinaga Shotaro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 11 Pages: 3920-3933
- DOI
  10.1074/jbc.ra118.005614
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06695, KAKENHI-PROJECT-16K18890
[Journal Article] Delayed Administration of BQ788, an ETB Antagonist, after Experimental Traumatic Brain Injury Promotes Recovery of Blood-Brain Barrier Function and a Reduction of Cerebral Edema in Mice.2018
- Author(s)
  Michinaga Shotaro, Kimura Akimasa, Hatanaka Shunichi, Minami Shizuho, Asano Arisa, Ikushima Yuki, Matsui Shingo, Toriyama Yoshiya, Fujii Manami, Koyama Yutaka.
- Journal Title
  
  Journal of neurotrauma
  
  Volume: 印刷中 Issue: 13 Pages: 1481-1494
- DOI
  10.1089/neu.2017.5421
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18890, KAKENHI-PROJECT-15K07981
[Journal Article] Protection of the Blood–Brain Barrier as a Therapeutic Strategy for Brain Damage2017
- Author(s)
  Shotaro Michnaga, Yutaka Koyama
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 5 Pages: 569-575
- DOI
  10.1248/bpb.b16-00991
- NAID
  130005631954
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07981, KAKENHI-PROJECT-16K18890
[Journal Article] The Endothelin ET<sub>B</sub> Receptor Antagonist BQ788 Protects against Brain Edema after Fluid Percussion Injury by Decreasing Vascular Endothelial Growth Factor-A Expression in Mice2017
- Author(s)
  Michinaga Shotaro
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 137 Issue: 10 Pages: 1241-1246
- DOI
  10.1248/yakushi.17-00134
- NAID
  130006109889
- ISSN
  0031-6903, 1347-5231
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18890
[Journal Article] Improvement of cold injury-induced mouse brain edema by endothelin ETB antagonists is accompanied by decreases in matrixmetalloproteinase 9 and vascular endothelial growth factor-A.2015
- Author(s)
  Shotaro Michinaga, Naoki Seno, Mayu Fuka, Yui Yamamoto, Shizuho Minami, Marina Nagase, Emi Matsuyama, Daisuke Yamanaka and Yutaka Koyama
- Journal Title
  
  European Journal of Neuroscience
  
  Volume: 42 Issue: 6 Pages: 2356-2370
- DOI
  10.1111/ejn.13020
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07981
[Journal Article] Pathogenesis of brain edema and investigation into anti-edema drugs2015
- Author(s)
  Shotaro Michinaga and Yutaka Koyama
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 16 Issue: 5 Pages: 9949-9975
- DOI
  10.3390/ijms16059949
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] アストロサイトの機能分子を標的とした脳損傷に対する創薬研究2023
- Author(s)
  道永昌太郎
- Organizer
  日本薬学会第143年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K16016
[Presentation] アストロサイトの機能分子を標的とした脳損傷に対する創薬研究（2023年日本薬学会奨励賞受賞講演）2023
- Author(s)
  道永昌太郎
- Organizer
  日本薬学会　第143年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06609
[Presentation] Sonic hedgehogシグナルは外傷性脳損傷による脳浮腫を抑制する2023
- Author(s)
  道永昌太郎, 小川泰弘, 菱沼滋
- Organizer
  第147回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-20K16016
[Presentation] Dual regulation of ERK phosphorylation by activation of Gq-protein and arrestin-mediated pathways via histamine H1 receptors2022
- Author(s)
  Shotaro Michinaga, Ayaka Nagata, Shigeru Hishinuma
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K16016
[Presentation] TRPV4阻害薬による外傷性脳損傷後の血管原性脳浮腫に対する抑制作用2022
- Author(s)
  道永昌太郎, 大西一也, 清水かほり, 水口博之, 菱沼滋
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K16016
[Presentation] ヒスタミンH2受容体作用薬による血管修復因子の発現増加を介した頭部外傷後のBlood-brain barrier破綻に対する抑制効果2022
- Author(s)
  道永昌太郎, 園田清美, 稲月直樹, 江嵜愛永, 粟根宙生, 清水かほり, 小川泰弘, 菱沼滋, 水口博之
- Organizer
  第146回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-20K16016
[Presentation] ヒスタミンH2受容体作用薬による外傷性脳損傷後のBlood-brain barrier破綻に対する抑制効果2022
- Author(s)
  道永昌太郎, 園田清美, 稲月直樹, 江嵜愛永, 粟根宙生, 清水かほり, 菱沼滋, 水口博之
- Organizer
  第23回日本ヒスタミン学会
- Data Source
  KAKENHI-PROJECT-20K16016
[Presentation] BQ788, a selective ETB receptor antagonist alleviates inflammatory reactions after traumatic brain injury in mice2022
- Author(s)
  Shotaro Michinaga, Hiroyuki Mizuguchi, Yasuhiro Ogawa, Shigeru Hishinuma, Yutaka Koyama
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K16016
[Presentation] BQ788, a selective ETB receptor antagonist alleviates inflammatory reactions after traumatic brain injury in mice2022
- Author(s)
  Shotaro Michinaga, Hiroyuki Mizuguchi, Yasuhiro Ogawa, Shigeru Hishinuma, Yutaka Koyama
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06609
[Presentation] BQ788, an endothelin ETB receptor antagonist alleviates blood-brain barrier disruption and brain edema after traumatic brain injury2021
- Author(s)
  Shotaro Michinaga, Hiroyuki Mizuguchi, Shigeru Hishinuma Yutaka Koyama
- Organizer
  The Seventeenth International Conference on Endothelin
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06609
[Presentation] アストロサイトの機能分子を標的とした頭部外傷に対する新規治療薬の開発2021
- Author(s)
  道永昌太郎、水口博之、菱沼滋、小山豊
- Organizer
  生体機能と創薬シンポジウム2021
- Data Source
  KAKENHI-PROJECT-21K06609
[Presentation] エンドセリン受容体拮抗薬ボセンタンの外傷性脳損傷に対する治療効果の検討2021
- Author(s)
  道永昌太郎, 井上杏奈, 龍亮太朗, 大西一也, 稲月直樹, 水口博之, 小山豊
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K16016
[Presentation] アストロサイトの機能分子を標的とした頭部外傷に対する新規治療薬の開発2021
- Author(s)
  道永昌太郎, 水口博之, 菱沼滋, 小山豊
- Organizer
  生体機能と創薬シンポジウム2021
- Data Source
  KAKENHI-PROJECT-20K16016
[Presentation] BQ788, an endothelin ETB receptor antagonist alleviates blood-brain barrier disruption and brain edema after traumatic brain injury2021
- Author(s)
  Shotaro Michinaga, Hiroyuki Mizuguchi, Shigeru Hishinuma, Yutaka Koyama
- Organizer
  Seventeenth International Conference on Endothelin
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16016
[Presentation] Amthamine, a selective histamine H2 receptor agonist alleviates cerebrovascular damage after traumatic brain injury in mice2021
- Author(s)
  Shotaro Michinaga, Kyomi Sonoda, Naoki Inazuki, Tomokazu Watano, Hiroyuki Mizuguchi
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K16016
[Presentation] 頭部外傷後のBlood-brain barrier破綻に対するSonic hedgehogの抑制効果2021
- Author(s)
  道永昌太郎, 粟根宙生, 稲月直樹, 江嵜愛永, 大西一也, 清水かほり, 水口博之, 小山豊, 菱沼滋
- Organizer
  第144回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-20K16016
[Presentation] エンドセリン受容体拮抗薬ボセンタンの外傷性脳損傷に対する治療効果の検討2021
- Author(s)
  道永昌太郎, 井上杏奈, 龍亮太朗, 大西一也, 稲月直樹, 水口博之, 小山　豊
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] エンドセリンETB受容体拮抗薬によるAngiopoietin-1-Tie-2シグナルを介した頭部外傷後のBlood-brain barrier破綻に対する抑制効果2020
- Author(s)
  道永昌太郎, 田邉彩美, 山本隼人, 水口博之, 小山豊
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] エンドセリンETB受容体拮抗薬BQ788によるsonic hedgehogの発現増加を介した頭部外傷後のBlood-brain barrier破綻に対する抑制効果2020
- Author(s)
  道永昌太郎, 井ノ上彩奈, 園田清美, 水口博之, 小山　豊
- Organizer
  第138回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] ヒスタミンH2受容体作用薬amthamineによる頭部外傷後のBlood-brain barrier破綻に対する抑制効果2020
- Author(s)
  道永昌太郎, 園田清美, 井ノ上彩奈, 水口博之
- Organizer
  第137回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-20K16016
[Presentation] エンドセリンETB受容体拮抗薬BQ788によるsonic hedgehogの発現増加を介した頭部外傷後のBlood-brain barrier破綻に対する抑制効果2020
- Author(s)
  道永昌太郎, 井ノ上彩奈, 園田清美, 水口博之, 小山豊
- Organizer
  第138回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-20K16016
[Presentation] Bosentan, an endothelin receptor antagonist ameliorates vasogenic edema after traumatic brain injury in mice2019
- Author(s)
  Shotaro Michinaga, Anna Inoue, Hayato Yamamoto, Ryotaro Ryu, Hiroyuki Mizuguchi, Yutaka Koyama
- Organizer
  The Sixteenth International Conference on Endothelin
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] エンドセリンETB受容体を介するアストロサイトNa-K-Cl共輸送体-1(NKCC1)の発現増加2019
- Author(s)
  小山　豊、濱田靖祥、井高佐知子、長田彩夏、道永昌太郎
- Organizer
  第136回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] 頭部外傷マウスにおけるBlood-brain barrierの破綻および脳浮腫に対するエンドセリン受容体拮抗薬Bosentanの効果2019
- Author(s)
  道永昌太郎, 中谷隆聖, 福留千裕, 井上杏奈, 岩根綾, 田邉彩美, 山本隼人, 龍亮太朗, 水口博之, 小山豊
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K18890
[Presentation] エンドセリン受容体拮抗薬Bosentanによる頭部外傷後の血管原生脳浮腫に対する抑制効果2019
- Author(s)
  道永昌太郎, 井上杏奈, 山本隼人, 龍亮太朗, 水口博之, 小山豊
- Organizer
  第135回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] 頭部外傷マウスにおけるBlood-brain barrierの破綻および脳浮腫に対するエンドセリン受容体拮抗薬Bosentanの効果2019
- Author(s)
  道永昌太郎, 中谷隆聖, 福留千裕, 井上杏奈, 岩根綾, 田邉彩美, 山本隼人, 龍　亮太朗, 水口博之, 小山豊
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] エンドセリンETB受容体拮抗薬BQ788による頭部外傷マウスにおける血管修復因子Angiopoietin-1の発現増加およびTie-2受容体の活性化2019
- Author(s)
  道永昌太郎、田邉彩美、山本隼人、龍　亮太朗、水口博之、小山豊
- Organizer
  生体機能と創薬シンポジウム2019
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] Blockade of endothelin ETB receptor ameliorates brain edema by regulation of astrocyte-derived factors after traumatic brain injury in mice2019
- Author(s)
  Shotaro Michinaga, Ryusei Nakaya, Chihiro Fukutome, Anna Inoue, Aya Iwane, Ayami Tanabe, Hayato Yamamoto, Ryotaro Ryu, Hiroyuki Mizuguchi, Yutaka Koyama
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16K18890
[Presentation] Endothelin-1 stimulates transcription of cyclin D1 and Skp2 through activation of Stat3 in cultured rat astrocytes2019
- Author(s)
  Yutaka Koyama, Satoshi Sumie, Yasutaka Nakano, Tomoya Nagao, Shiho Tokumaru, and Shotaro Michinaga
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] Blockade of endothelin ETB receptor ameliorates brain edema by regulation of astrocyte-derived factors after traumatic brain injury in mice2019
- Author(s)
  Shotaro Michinaga, Ryusei Nakaya, Chihiro Fukutome, Anna Inoue, Aya Iwane, Ayami Tanabe, Hayato Yamamoto, Ryotaro Ryu, Hiroyuki Mizuguchi and Yutaka Koyama
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] Blockade of endothelin ETB receptor ameliorates blood-brain barrier disruption through increase of angiopoietin-1 after traumatic brain injury.2018
- Author(s)
  Shotaro Michinaga, Ryusei Nakaya, Chihiro Fukutome, Anna Inoue, Aya Iwane, Ayami Tanabe, Yutaka Koyama
- Organizer
  18 th World congress of basic and clinical pharmacology 2018
- Data Source
  KAKENHI-PROJECT-16K18890
[Presentation] 頭部外傷マウスのBlood-brain barrier破綻に対するエンドセリンETB受容体拮抗薬BQ788による血管修復因子Angiopoietin-1の発現増加を介した抑制効果2018
- Author(s)
  道永昌太郎, 中谷隆聖, 福留千裕, 井上杏奈, 岩根綾, 田邉彩美, 山本隼人, 水口博之, 小山豊
- Organizer
  第134回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] 頭部外傷マウスのBlood-brain barrier破綻に対する血管修復因子Angiopoietin-1の発現増加を介した抑制効果2018
- Author(s)
  道永昌太郎, 中谷隆聖, 福留千裕, 井上杏奈, 岩根綾, 田邉彩美, 山本隼人, 水口博之, 小山豊
- Organizer
  第134回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-16K18890
[Presentation] 頭部外傷マウスにおけるBlood-brain barrierの破綻に対するエンドセリンETB受容体拮抗薬の効果2018
- Author(s)
  道永昌太郎、鳥山佳勇、藤井愛望、小山豊
- Organizer
  日本薬学会　第138回年会
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] 頭部外傷マウスにおけるBlood-brain barrierの破綻に対するエンドセリンETB受容体拮抗薬の効果2018
- Author(s)
  道永　昌太郎、鳥山　佳勇、藤井　愛望、小山　豊
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K18890
[Presentation] Blockade of endothelin ETB receptor ameliorates blood-brain barrier disruption through increase of angiopoietin-1 after traumatic brain injury in mice2018
- Author(s)
  Shotaro Michinaga, Ryusei Nakaya, Chihiro Fukutome, Anna Inoue, Aya Iwane, Ayami Tanabe and Yutaka Koyama
- Organizer
  The 18th World Congress of Basical and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06695
[Presentation] エンドセリンETB受容体拮抗薬によるマウス頭部外傷後の血液脳関門の破綻および脳浮腫に対する抑制効果2018
- Author(s)
  道永昌太郎, 中谷隆聖, 福留千裕, 井上杏奈, 岩根綾, 田邉彩美, 山本隼人, 水口博之, 小山豊
- Organizer
  第12回次世代を担う若手医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-16K18890
[Presentation] Amelioration of BBB disruption and brain edema by BQ788, an endothelin ETB receptor antagonist through attenuation of matrix metalloproteinase-9 in cerebral contusion mice2017
- Author(s)
  Shotaro Michinaga, Yoshiya Toriyama, Manami Fujii and Yutaka Koyama
- Organizer
  第40回日本神経科学学会
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] BQ788, an Endothelin ETB receptor antagonist, improves disruption of blood brain barrier by affecting VEGF-A and claudin-5 expressions in cerebral contusion mice.2017
- Author(s)
  道永昌太郎, 麻野有沙, 生島佑起, 松井伸悟, 木村章政, 畠中駿一, 南志津保, 小山豊.
- Organizer
  第90回日本薬理学会年会.
- Place of Presentation
  長崎ブリックホール, 長崎新聞文化ホール　アストピア（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K18890
[Presentation] エンドセリンETB受容体遮断薬BQ788による脳挫傷後の血液脳関門破綻に対する抑制効果の機序解明―VEGF-Aおよびclaudin-5の関与―2017
- Author(s)
  道永昌太郎, 麻野有沙, 生島佑起, 松井伸悟, 木村章政, 畠中駿一, 南志津保, 小山豊
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県、長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] 脳挫傷後のマウス脳浮腫に対するエンドセリンETB受容体拮抗薬BQ788の効果2017
- Author(s)
  道永　昌太郎
- Organizer
  第67回日本薬学会近畿支部総会・大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K18890
[Presentation] Amelioration of BBB disruption and brain edema by BQ788, an endothelin ETB receptor antagonist through attenuation of matrix metalloproteinase-9 in cerebral contusion mice2017
- Author(s)
  道永　昌太郎、鳥山　佳勇、藤井　愛望、小山　豊
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K18890
[Presentation] 脳挫傷後の脳血管障害に対するエンドセリンETB受容体拮抗薬の効果2017
- Author(s)
  道永　昌太郎, 小山　豊
- Organizer
  第19回応用薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] 脳挫傷後のマウス脳浮腫に対するエンドセリンETB受容体拮抗薬BQ788の効果2017
- Author(s)
  道永昌太郎
- Organizer
  第67回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] 脳挫傷後の脳血管障害に対するエンドセリンETB受容体拮抗薬の効果2017
- Author(s)
  道永　昌太郎、小山　豊
- Organizer
  第19回応用薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-16K18890
[Presentation] Effects of endothelin ETB receptor antagonist on acceleration of cerebral microvascular permeability and brain edema formation after fluid percussion injury in mice2016
- Author(s)
  Shotaro Michinaga, Akimasa Kimura, Shunichi Hatanaka, Shizuho Minami, Arisa Asano, Yuki Ikushima, Shingo Matsui, Yutaka Koyama
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜　（神奈川県、横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] 流体衝撃による脳傷害後のマウス脳浮腫に対するエンドセリンETB受容体遮断薬の効果―血管透過性亢進因子VEGF-Aの関与―2016
- Author(s)
  道永昌太郎, 麻野有沙, 生島佑起, 松井伸悟, 木村光克, 畠中駿一, 南志津保, 小山豊.
- Organizer
  第66回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学（大阪府高槻市）
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-16K18890
[Presentation] Fluid percussion injury後のマウス脳浮腫に対するエンドセリン受容体遮断薬の効果―ETA遮断薬とETB遮断薬の異なる効果―2016
- Author(s)
  道永昌太郎, 木村章政, 畠中駿一, 南志津保, 麻野有沙, 生島佑起, 松井伸悟, 小山豊
- Organizer
  第129回日本薬理学会近畿部会
- Place of Presentation
  広島県医師会館 (広島県、広島市)
- Year and Date
  2016-06-24
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] Fluid percussion injury後のマウス脳浮腫に対するエンドセリン受容体遮断薬の効果-ETA遮断薬とETB遮断薬の異なる効果2016
- Author(s)
  道永昌太郎, 木村光克, 畠中駿一, 南志津保, 麻野有沙, 生島佑起, 松井伸悟, 小山豊
- Organizer
  第129回日本薬理学会近畿部会
- Place of Presentation
  広島県医師会館（広島県広島市）
- Year and Date
  2016-06-24
- Data Source
  KAKENHI-PROJECT-16K18890
[Presentation] Attenuation of fluid percussion injury induced-brain edema formation by BQ788, an endothelin ETB receptor antagonist, in mice2016
- Author(s)
  Shotaro Michinaga, Akimasa Kimura, Shunichi Hatanaka, Shizuho Minami and Yutaka Koyama
- Organizer
  第89回　日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2016-03-10
- Data Source
  KAKENHI-PROJECT-15K07981
[Presentation] Effects of endothelin ETB receptor antagonist on acceleration of cerebral microvascular permeability and brain edema formation after fluid percussion injury in mice.2016
- Author(s)
  道永昌太郎, 木村光克, 畠中駿一, 南志津保, 麻野有沙, 生島佑起, 松井伸悟, 小山豊
- Organizer
  第39回日本神経科学大会.
- Place of Presentation
  パシフィコ横浜（神奈川横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-16K18890
[Presentation] 流体衝撃による脳傷害後のマウス脳浮腫に対するエンドセリンETB受容体遮断薬の効果 ―血管透過性亢進因子VEGF-Aの関与―2016
- Author(s)
  道永昌太郎, 麻野有沙, 生島佑起, 松井伸悟, 木村光克, 畠中駿一, 南志津保, 小山豊
- Organizer
  第66 回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学　（大阪府、高槻市）
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-15K07981

1. Koyama Yutaka (00215435)

# of Collaborated Projects: 3 results

# of Collaborated Products: 33 results
2. 泉安彦 (60456837)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results

Michinaga Shotaro 道永 昌太郎

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ソニックヘッジホッグ関連分子に着目した外傷性脳損傷に対する新規治療薬の創出Principal Investigator

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Development of therapeutic drugs for traumatic brain injury (TBI) to target astroglial endothelin receptors

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Development of novel therapeutic drugs for traumatic brain injury focused on functional molecules in astrocytesPrincipal Investigator

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Development of novel astrocyte-targeted drugs against brain edema and neuronal injury

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Exploration of novel anti-edema drugs by regulation of astroglial functionsPrincipal Investigator

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Research and development of novel neuroprotective drugs targeting endothelin ETB receptor

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[Book] Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury (Rajendram et al. ed) 1st Edition, Chapter 182022

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[Journal Article] Roles of astrocytic sonic hedgehog production and its signal for regulation of the blood-brain barrier permeability2024

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[Journal Article] Roles of Astrocytic Endothelin ETB Receptor in Traumatic Brain Injury2023

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[Journal Article] Selective histamine H2 receptor agonists alleviate blood-brain barrier disruption by promoting the expression of vascular protective factors following traumatic brain injury in mice2022

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[Journal Article] Pathophysiological Responses and Roles of Astrocytes in Traumatic Brain Injury2021

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[Journal Article] Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 Reduces Vasogenic Edema after Traumatic Brain Injury in Mice2021

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[Journal Article] Down-regulation of astrocytic sonic hedgehog by activation of endothelin ETB receptors: Involvement in traumatic brain injury-induced disruption of blood brain barrier in a mouse model2021

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Michinaga Shotaro 道永昌太郎