Takai Akira 高井啓

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TAKAI Akira 高井啓

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Researcher Number	60637205
Affiliation (Current)	2025: 東京大学, 大学院医学系研究科(医学部), 助教
Affiliation (based on the past Project Information) *help	2023: 東京大学, 大学院医学系研究科(医学部), 助教 2018 – 2021: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員 2015 – 2016: 国立研究開発法人理化学研究所, 生命システム研究センター, 基礎科学特別研究員 2013 – 2014: 独立行政法人理化学研究所, 生命システム研究センター, 特別研究員
Review Section/Research Field	Principal Investigator Basic Section 48010:Anatomy-related / General anatomy (including histology/embryology) / Developmental biology Except Principal Investigator General anatomy (including histology/embryology)
Keywords	Principal Investigator ライブイメージング / RNA / 発生生物学 / シグナル伝達 / イメージングプローブ / 細胞生物学 / 液－液相分離 / 遺伝子発現 / プローブ開発 / Wntシグナル / ルシフェラーゼ / RNAイメージング / 発光イメージング … More Except Principal Investigator … More 微小管結合タンパク質 / キネシン / 分子モーター / 微小管 / 細胞極性 / 細胞内輸送 Less

Phase-separation dynamics of pathogenic RNA granules revealed by visualization and manipulation method of endogenous RNAPrincipal Investigator
- Principal Investigator
  
  Takai Akira
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  The University of Tokyo
  Institute of Physical and Chemical Research
Development of visualization and manipulation of RNAs based on artificial RNA-binding protein and analysis of sum total RNAPrincipal Investigator
- Principal Investigator
  
  Takai Akira
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Institute of Physical and Chemical Research
Development of visualization method of phosphorylation dynamics of beta-catenin for the study of in vivo Wnt signal regulation machineryPrincipal Investigator
- Principal Investigator
  
  Takai Akira
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Institute of Physical and Chemical Research
Mechanisms for the navigation of the intracellular transport
- Principal Investigator
  
  Okada Yasushi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Institute of Physical and Chemical Research
Development of real-time detection method of mRNA dynamics for the study of signal regulation system during left-right asymmetry formationPrincipal Investigator
- Principal Investigator
  
  TAKAI Akira
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  The Institute of Physical and Chemical Research

All 2020 2019 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] An Improved Fluorescent Protein-Based Expression Reporter System That Utilizes Bioluminescence Resonance Energy Transfer and Peptide-Assisted Complementation2020
- Author(s)
  Taishi Kakizuka, Akira Takai, Keiko Yoshizawa, Yasushi Okada, Tomonobu M Watanabe
- Journal Title
  
  Chemical Communications
  
  Volume: 56 Issue: 25 Pages: 3625-3628
- DOI
  10.1039/c9cc08664a
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06848, KAKENHI-PLANNED-18H05409, KAKENHI-PROJECT-19H03394, KAKENHI-ORGANIZER-19H05794, KAKENHI-PLANNED-19H05795
[Journal Article] Development and applications of three color variants of bright luminescent protein probes2016
- Author(s)
  高井啓、岡田康志
- Journal Title
  
  生化学
  
  Volume: 88 Issue: 5 Pages: 669-673
- DOI
  10.14952/SEIKAGAKU.2016.880669
- NAID
  40020998673
- ISSN
  0037-1017
- Year and Date
  2016-10-25
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K21625
[Journal Article] Expanded palette of Nano-lantern for real-time muliti-color luminescence imaging2015
- Author(s)
  Takai A, Nakano M, Saito K, Haruno R, Watanabe TM, Ohyanagi T, Jin T, Okada Y, Nagai T
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 112 Issue: 14 Pages: 4352-4356
- DOI
  10.1073/pnas.1418468112
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23115003, KAKENHI-PUBLICLY-25113723, KAKENHI-PROJECT-25293046, KAKENHI-PROJECT-25871128, KAKENHI-PUBLICLY-26115721, KAKENHI-PROJECT-15K07040, KAKENHI-PROJECT-26291028
[Presentation] Development and application of designer RNA-binding protein for live-cell RNA imaging and manipulation of authentic RNAs in living cells2019
- Author(s)
  Akira Takai and Yasushi Okada
- Organizer
  2019 ASCB|EMBO Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06848
[Presentation] Development of designable RNA-binding proteins for visualization and manipulation of authentic RNAs in living cells2019
- Author(s)
  Akira Takai and Yasushi Okada
- Organizer
  第57回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-18K06848
[Presentation] Development and application of designer RNA-binding protein for live-cell imaging and manipulation of authentic RNAs2019
- Author(s)
  Akira Takai and Yasushi Okada
- Organizer
  第19回日本蛋白質科学会年会　第71回日本細胞生物学会大会　合同年次大会
- Data Source
  KAKENHI-PROJECT-18K06848
[Presentation] 超高輝度マルチカラー発光タンパク質Nano-lanternを用いた迅速かつ高感度な遺伝子転写活性・分子間相互作用の定量計測2017
- Author(s)
  高井啓、岡田康志
- Organizer
  第122回日本解剖学会総会・全国学術集会
- Place of Presentation
  長崎大学（長崎県長崎市）
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-15K21625
[Presentation] An expanded color palette of super-brilliant luminescent proteins for multicolor, real-time bioluminescence imaging2015
- Author(s)
  高井啓　他
- Organizer
  The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  シェラトンワイキキ（米国ハワイ州）
- Year and Date
  2015-12-15
- Data Source
  KAKENHI-PROJECT-15K21625
[Presentation] 超高輝度発光タンパク質の多色化による遺伝子発現、オルガネラ動態および機能分子動態のマルチカラー・リアルタイムイメージング2015
- Author(s)
  高井啓　他
- Organizer
  第67回日本細胞生物学会大会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-15K21625
[Presentation] Multicolor Nano-lanterns: the tricolored and super-brilliant luminescent proteins for multicolor, real-time bioluminescence imaging2015
- Author(s)
  高井啓　他
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  金沢大学（石川県金沢市）
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-15K21625
[Presentation] 超高輝度発光タンパク質の波長変異体による生体内機能・構造のマルチカラーイメージング2014
- Author(s)
  高井啓　他
- Organizer
  第119回日本解剖学会総会全国学術集会
- Place of Presentation
  自治医科大学（栃木県）
- Data Source
  KAKENHI-PROJECT-25871128
[Presentation] 超高輝度発光タンパク質の波長変異体による細胞内機能・構造のマルチカラーイメージング2013
- Author(s)
  高井啓　他
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  ウインク愛知（愛知県）
- Data Source
  KAKENHI-PROJECT-25871128
[Presentation] Development of three color variants of super-brilliant luciferase for multi-color, real time imaging of gene expression and dynamics of organelles and the cytoskeleton without external illumination
- Author(s)
  Takai A., Haruno, R., Nagai, T. and Okada, Y.
- Organizer
  The 2014 American Society for Cell Biology/International Federation for Cell Biology Meeting
- Place of Presentation
  フィラデルフィア（アメリカ）
- Year and Date
  2014-12-06 – 2014-12-10
- Data Source
  KAKENHI-PROJECT-25871128
[Presentation] Development of three color variants of super-brilliant luminescent proteins for multicolor, real-time bioluminescent imaging
- Author(s)
  Takai A., Haruno, R., Nagai, T. and Okada, Y.
- Organizer
  第120回日本解剖学会総会・全国学術集会 / 第92回日本生理学会大会合同大会
- Place of Presentation
  神戸国際会議場・展示場（神戸市）
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-25871128
[Presentation] Multicolor imaging of cellular structure with wavelength variants of super-duper luminescent proteins
- Author(s)
  Takai, A., Haruno,R., Okada, Y. and Nagai, T.
- Organizer
  第37回内藤コンファレンス
- Place of Presentation
  ヒルトンニセコビレッジ（北海道虻田郡ニセコ町）
- Year and Date
  2014-07-15 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-25871128

1. Ikeda Kazuho (20642565)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. Okada Yasushi (50272430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Shima Tomohiro (60631786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Ito Yoko (60584571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 有吉哲郎 (00782103)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 永井健治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takai Akira 高井 啓

TAKAI Akira 高井 啓

Research Projects

Research Products

Co-Researchers

Phase-separation dynamics of pathogenic RNA granules revealed by visualization and manipulation method of endogenous RNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of visualization and manipulation of RNAs based on artificial RNA-binding protein and analysis of sum total RNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of visualization method of phosphorylation dynamics of beta-catenin for the study of in vivo Wnt signal regulation machineryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms for the navigation of the intracellular transport

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of real-time detection method of mRNA dynamics for the study of signal regulation system during left-right asymmetry formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] An Improved Fluorescent Protein-Based Expression Reporter System That Utilizes Bioluminescence Resonance Energy Transfer and Peptide-Assisted Complementation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development and applications of three color variants of bright luminescent protein probes2016

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Expanded palette of Nano-lantern for real-time muliti-color luminescence imaging2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] Development and application of designer RNA-binding protein for live-cell RNA imaging and manipulation of authentic RNAs in living cells2019

Author(s)

Organizer

Data Source

[Presentation] Development of designable RNA-binding proteins for visualization and manipulation of authentic RNAs in living cells2019

Author(s)

Organizer

Data Source

[Presentation] Development and application of designer RNA-binding protein for live-cell imaging and manipulation of authentic RNAs2019

Author(s)

Organizer

Data Source

[Presentation] 超高輝度マルチカラー発光タンパク質Nano-lanternを用いた迅速かつ高感度な遺伝子転写活性・分子間相互作用の定量計測2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] An expanded color palette of super-brilliant luminescent proteins for multicolor, real-time bioluminescence imaging2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 超高輝度発光タンパク質の多色化による遺伝子発現、オルガネラ動態および機能分子動態のマルチカラー・リアルタイムイメージング2015

Author(s)

Takai Akira 高井啓

TAKAI Akira 高井啓