Alam Mohammad Towfik アラム M・トウフィック

Researcher Number	60641694
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2020: 北海道大学, 歯学研究院, 学術研究員 2016: 北海道大学, 歯学研究科, 学術研究員 2015: 北海道大学, 歯学研究科(研究院), 研究員 2014: 北海道大学, 歯学研究科(研究院), 学術研究員
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Morphological basic dentistry
Keywords	Principal Investigator トランスレーショナルリサーチ / 癌 / 腫瘍溶解ウイルス / エタノール / 溶解 / 腫瘍 / 口腔がん / アデノウイルス / 血管新生阻害療法 / 腫瘍血管内皮細胞、 / 薬剤抵抗性 / がん幹細胞 / 腫瘍血管内皮細胞

Attempt to enhance the effect of oncolytic adenovirus.Principal Investigator
- Principal Investigator
  
  Alam Mohammad Towfik
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Hokkaido University
Overcome the drug resistance by targeting tumor endothelial markersPrincipal Investigator
- Principal Investigator
  
  Alam Mohammad Towfik
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Hokkaido University

All 2020 2019 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Conditionally Replicative Adenovirus Controlled by the Stabilization System of AU-Rich Elements Containing mRNA2020
- Author(s)
  Mikawa Yohei、Towfik Alam Mohammad、Hossain Elora、Yanagawa-Matsuda Aya、Kitamura Tetsuya、Yasuda Motoaki、Habiba Umma、Ahmed Ishraque、Kitagawa Yoshimasa、Shindoh Masanobu、Higashino Fumihiro
- Journal Title
  
  Cancers
  
  Volume: 12 Issue: 5 Pages: 1205-1205
- DOI
  10.3390/cancers12051205
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10326, KAKENHI-PROJECT-20K09900, KAKENHI-PROJECT-17H04401, KAKENHI-PROJECT-18K09737, KAKENHI-PROJECT-19K19221
[Journal Article] Enhanced oncolytic activity of E4orf6-deficient adenovirus by facilitating nuclear export of HuR.2020
- Author(s)
  Ahmed I., Towfik Alam M., Yanagawa-Matsuda A., Hossain E., Kitamura T., Minowa K., Higashino F.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 529 Pages: 494-499
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K19221
[Journal Article] Advantages of Using Paclitaxel in Combination with Oncolytic Adenovirus Utilizing RNA Destabilization Mechanism2020
- Author(s)
  Hossain Elora、Habiba Umma、Yanagawa-Matsuda Aya、Alam Arefin、Ahmed Ishraque、Towfik Alam Mohammad、Yasuda Motoaki、Higashino Fumihiro
- Journal Title
  
  Cancers
  
  Volume: 12 Issue: 5 Pages: 1210-1210
- DOI
  10.3390/cancers12051210
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09900, KAKENHI-PROJECT-17H04401, KAKENHI-PROJECT-19K19221
[Journal Article] Comparison of characteristics of mouse immortalized normal endothelial cells, MS1 and primary cultured endothelial cells.2016
- Author(s)
  *Hida K., Maishi N., Torii C., Yanagiya M., Annan Akuba-Muhyia Dorcas., Morimoto M., Alam Mohammad Towfik
- Journal Title
  
  Hokkaido J. Dent. Sci.
  
  Volume: 37 Pages: 40-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26861540
[Journal Article] Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan.2016
- Author(s)
  N. Maishi, Y. Ohba, K. Akiyama, N. Ohga, J.I. Hamada, H. Nagao-Kitamoto, M. Alam, K. Yamamoto, T. Kawamoto, N. Inoue, A. Taketomi, M. Shindoh, Y. Hida and K. Hida.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 28039-28039
- DOI
  10.1038/srep28039
- NAID
  120005819304
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01248, KAKENHI-PROJECT-26293041, KAKENHI-PROJECT-26462388, KAKENHI-PROJECT-26462390, KAKENHI-PROJECT-26463035, KAKENHI-PROJECT-15K15023, KAKENHI-PROJECT-15K15726, KAKENHI-PROJECT-15K20357, KAKENHI-PROJECT-26861540, KAKENHI-PROJECT-16K20554, KAKENHI-PROJECT-15KK0290, KAKENHI-PROJECT-15H04941
[Journal Article] CXCL 12-CXCR7 axis is important for tumor endothelial cell angiogenic property2015
- Author(s)
  Yamada K., Maishi N., Akiyama K., Alam Mohammad Towfik, Ohga N., Kawamoto T., Shindoh M. Takahashi N., Kamiyama T., Hida Y., Taketomi A. and Hida K.
- Journal Title
  
  Int J Cancer
  
  Volume: 137(12) Issue: 12 Pages: 2825-2836
- DOI
  10.1002/ijc.29655
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K20357, KAKENHI-PROJECT-26861540, KAKENHI-PROJECT-26861694, KAKENHI-PROJECT-25462846, KAKENHI-PROJECT-25462909, KAKENHI-PROJECT-25463106, KAKENHI-PROJECT-26861698, KAKENHI-PROJECT-24390324, KAKENHI-PROJECT-15K15726, KAKENHI-PROJECT-15H04941
[Journal Article] Inhibition of multidrug transporter in tumor endothelial cells enhances antiangiogenic effects of low-dose metronomic paclitaxel2015
- Author(s)
  1.Akiyama K., Maishi N., Ohga N., Hida Y., Ohba Y., Alam Mohammad Towfik, Kawamoto T., Ohmura H., Yamada K., Torii C., Shindoh M. and *Hida K.
- Journal Title
  
  Am J Pathol
  
  Volume: 185(2) Issue: 2 Pages: 572-580
- DOI
  10.1016/j.ajpath.2014.10.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390448, KAKENHI-PROJECT-24791958, KAKENHI-PROJECT-25462909, KAKENHI-PROJECT-25670184, KAKENHI-PUBLICLY-26115701, KAKENHI-PROJECT-26293041, KAKENHI-PROJECT-26861694, KAKENHI-PROJECT-26463035, KAKENHI-PROJECT-15K20357, KAKENHI-PROJECT-26861540, KAKENHI-PROJECT-25462846, KAKENHI-PROJECT-26861698, KAKENHI-PROJECT-15K15726
[Journal Article] Suprabasin as a novel tumor endothelial cell marker2014
- Author(s)
  3.Alam Mohammad Towfik，Nagao-Kitamoto H., Ohga N., Akiyama K., Maishi N., Kawamoto T., Shinohara N., Taketomi A., Shindoh M., Hida Y. and *Hida K
- Journal Title
  
  Cancer Sci
  
  Volume: 105(12) Issue: 12 Pages: 1533-1540
- DOI
  10.1111/cas.12549
- NAID
  120005539218
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390448, KAKENHI-PROJECT-24791958, KAKENHI-PROJECT-25462846, KAKENHI-PROJECT-25462909, KAKENHI-PROJECT-25463106, KAKENHI-PROJECT-25670564, KAKENHI-PROJECT-26463035, KAKENHI-PROJECT-26861540, KAKENHI-PROJECT-26861694, KAKENHI-PROJECT-26861698
[Presentation] Oncolytic potential of an E4-deficient adenovirus that can recognize the stabilization of AU-rich element containing mRNA in cancer cells.2019
- Author(s)
  Fumihiro Higashino, Aya Yanagawa-Matsuda, Mohammad Towfik-Alam, Tetsuya Kitamura
- Organizer
  第25回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K19221
[Presentation] Tumor endothelial cells acquire drug resistance by exosomal-miR derived from high metastatic tumor2016
- Author(s)
  Hida K., Torii C., Maishi N., Morimoto M., Akiyama K., Kawamoto T., Minami T., Yoshioka Y., Mohammad Towfik Alam, Shindoh M., Hida Y., Ochiya T
- Organizer
  ： The 19th International Vascular Biology Meeting 国際学会
- Place of Presentation
  Boston, Massachusetts, USA
- Year and Date
  2016-11-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861540
[Presentation] Tumor endothelial cells in high metastatic tumors promote metastasis via biglycan,2016
- Author(s)
  Maishi N., Ohba Y., Akiyama K., Ohga N., Hamada J., Nagao-Kitamoto H., Mohammad Towfik Alam, Shindoh M., Hida Y. Hida K.
- Organizer
  The 19th International Vascular Biology Meeting
- Place of Presentation
  Boston, Massachusetts, USA
- Year and Date
  2016-11-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861540
[Presentation] Tumor endothelial cells promote metastasis via biglycan secretion2016
- Author(s)
  Maishi N., Ohba Y., Akiyama K., Ohga N., Hamada J., Mohammad Towfik Alam, Shindoh M., Hida Y., Hida K
- Organizer
  Tenth AACR-JCA Joint Conference “Breakthroughs in Cancer Research: From Biology to Therapeutics”
- Place of Presentation
  Maui (USA)
- Year and Date
  2016-02-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861540
[Presentation] Suprabasin as a novel tumor endothelial cell marker2015
- Author(s)
  Alam Mohammad Towfik，Nagao-Kitamoto H., Ohga N., Akiyama K., Maishi N., Shinohara N., Taketomi A.
- Organizer
  第26回日本臨床口腔病理学会総会・学術大会
- Place of Presentation
  北海道大学学術交流会館（北海道・札幌市）
- Year and Date
  2015-07-31
- Data Source
  KAKENHI-PROJECT-26861540
[Presentation] 腫瘍血管内皮細胞はbiglycanの分泌を介してがんの転移を促進する2015
- Author(s)
  間石奈湖，大場雄介，秋山廣輔，大賀則孝，浜田淳一，北本宗子，Alam Mohammad Towfik，進藤正信，樋田泰浩，樋田京子
- Organizer
  第26回日本臨床口腔病理学会総会・学術大会
- Place of Presentation
  北海道大学学術交流会館（北海道・札幌市）
- Year and Date
  2015-07-31
- Data Source
  KAKENHI-PROJECT-26861540
[Presentation] ROS によるbiglycan 発現誘導を介した腫瘍血管内皮細胞の血管新生能亢進2015
- Author(s)
  北條敬之，間石奈湖，Mohammad T Alam，秋山廣輔，大賀則孝，進藤正信，樋田泰浩，藤澤俊明，樋田京子
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-26861540
[Presentation] 腫瘍血管内皮細胞はbiglycan の分泌を介してがんの転移を促進する2015
- Author(s)
  間石奈湖，大場雄介，秋山廣輔，大賀則孝，浜田淳一，北本(永尾）宗子，Mohammad Alam T.，進藤正信，樋田泰浩，樋田京子
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26861540
[Presentation] Tumor endothelial cells promote metastasis via biglycan secretion2015
- Author(s)
  Maishi N., Ohba Y., Akiyama K., Ohga N., Hamada J., Mohammad Towfik Alam, Shindoh M., Hida Y., Hida K
- Organizer
  The European Cancer Congress 2015
- Place of Presentation
  Vienna (Austria)
- Year and Date
  2015-09-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861540
[Presentation] P-gp inhibitor enhances antiangiogenic activity in metronomic chemotherapy
- Author(s)
  Akiyama K., Ohga N., Hida Y., Maishi N., Alam Mohammad Towfik, Kawamoto T., Omura H., Yamada Y., Torii C., Shindoh M., Ohba Y., Hida K.
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  みやこめっせ(京都府・京都市）
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-26861540
[Presentation] SBSN is a novel Tumor Endothelial Cell marker
- Author(s)
  Alam Mohammad Towfik, Nagao H., Ohga N., Akiyama K., Maishi N., Kawamoto T., Shinohara N., Taketomi A., Shindoh M., Hida Y., Hida K
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  みやこめっせ(京都府・京都市）
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-26861540
[Presentation] CXCL12/CXCR7 axis is important for tumor endothelial cell angiogenic property
- Author(s)
  Yamada K., Maishi N. Ohga N., Akiyama K., Kawamoto T., Alam Mohammad Towfik, Shindoh M. Takahashi N., Kamiyama T., Hida Y., Taketomi A., Hida K.
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  みやこめっせ(京都府・京都市）
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-26861540

1. MATSUDA Aya

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. HIDA Kyoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 東野史裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 北村哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 秋山廣輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 大場雄介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 大賀則孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 進藤正信

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Alam Mohammad Towfik アラム M・トウフィック

Research Projects

Research Products

Co-Researchers

Attempt to enhance the effect of oncolytic adenovirus.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Overcome the drug resistance by targeting tumor endothelial markersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Conditionally Replicative Adenovirus Controlled by the Stabilization System of AU-Rich Elements Containing mRNA2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhanced oncolytic activity of E4orf6-deficient adenovirus by facilitating nuclear export of HuR.2020

Author(s)

Journal Title

Data Source

[Journal Article] Advantages of Using Paclitaxel in Combination with Oncolytic Adenovirus Utilizing RNA Destabilization Mechanism2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of characteristics of mouse immortalized normal endothelial cells, MS1 and primary cultured endothelial cells.2016

Author(s)

Journal Title

Data Source

[Journal Article] Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan.2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] CXCL 12-CXCR7 axis is important for tumor endothelial cell angiogenic property2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of multidrug transporter in tumor endothelial cells enhances antiangiogenic effects of low-dose metronomic paclitaxel2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Suprabasin as a novel tumor endothelial cell marker2014

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] Oncolytic potential of an E4-deficient adenovirus that can recognize the stabilization of AU-rich element containing mRNA in cancer cells.2019

Author(s)

Organizer

Data Source

[Presentation] Tumor endothelial cells acquire drug resistance by exosomal-miR derived from high metastatic tumor2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Tumor endothelial cells in high metastatic tumors promote metastasis via biglycan,2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Tumor endothelial cells promote metastasis via biglycan secretion2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Suprabasin as a novel tumor endothelial cell marker2015

Author(s)