Mino Takashi 三野享史

… Alternative Names

MINO Takashi 三野享史

Less

Researcher Number	60646149
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2024: 京都大学, 医学研究科, 助教 2019 – 2022: 京都大学, 医学研究科, 助教 2016 – 2019: 京都大学, ウイルス・再生医科学研究所, 助教 2013 – 2014: 京都大学, ウイルス研究所, 助教
Review Section/Research Field	Principal Investigator Immunology / Basic Section 48040:Medical biochemistry-related / Basic Section 49070:Immunology-related Except Principal Investigator Broad Section H
Keywords	Principal Investigator 翻訳 / UPF1 / Regnase-1 / サイトカイン / 自然免疫 / 免疫 / mRNA分解 / 転写後制御 / RNA構造 / 5′ 非翻訳領域(5′ UTR) … More / 炎症性サイトカイン / mRNA / リボソーム / mRNA安定性制御 / TTP / Ribosome / RNA安定性制御 / 転写後調節 / 炎症 … More Except Principal Investigator 免疫制御 / サイトカイン / 免疫応答 / ｍRNA分解 / mRNA制御 / 自然免疫応答 / mRNA修飾 / 免疫細胞分化 / 核酸医薬 / mRNA分解 / 炎症性疾患 Less

Molecular basis of translational regulation in immune systemPrincipal Investigator
- Principal Investigator
  
  三野享史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kyoto University
Study of mRNA translation in immune systemPrincipal Investigator
- Principal Investigator
  
  Mino Takahsi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kyoto University
Analysis of immune regulatory mechanisms mediated by mRNA metabolism
- Principal Investigator
  
  Takeuchi Osamu
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section H
- Research Institution
  Kyoto University
Study of UPF1-mediated mRNA regulation in immune systemPrincipal Investigator
- Principal Investigator
  
  MINO Takashi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
Analysis of posttranscriptional mechanisms of Regnase-1-mediated mRNA decay in innate immune systemPrincipal Investigator
- Principal Investigator
  
  MINO Takashi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Patent

[Journal Article] Cyclin J-CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism2022
- Author(s)
  Chong Yee Kien、Tartey Sarang、Yoshikawa Yuki、Imami Koshi、Li Songling、Yoshinaga Masanori、Hirabayashi Ai、Liu Guohao、Vandenbon Alexis、Hia Fabian、Uehata Takuya、Mino Takashi、Suzuki Yutaka、Noda Takeshi、Ferrandon Dominique、Standley Daron M.、Ishihama Yasushi、Takeuchi Osamu
- Journal Title
  
  Science Signaling
  
  Volume: 15 Issue: 729 Pages: 1-19
- DOI
  10.1126/scisignal.abm5011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04844, KAKENHI-PUBLICLY-21H05720, KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-20H03241, KAKENHI-PROJECT-20F20115, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-21K15372, KAKENHI-PROJECT-20K22737
[Journal Article] Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages2022
- Author(s)
  Yaku Ai、Inagaki Tadakatsu、Asano Ryotaro、Okazawa Makoto、Mori Hiroyoshi、Sato Ayuko、Hia Fabian、Masaki Takeshi、Manabe Yusuke、Ishibashi Tomohiko、Vandenbon Alexis、Nakatsuka Yoshinari、Akaki Kotaro、Yoshinaga Masanori、Uehata Takuya、Mino Takashi、Morita Satoshi、Ishibashi-Ueda Hatsue、Morinobu Akio et al.
- Journal Title
  
  Circulation
  
  Volume: 146 Issue: 13 Pages: 1006-1022
- DOI
  10.1161/circulationaha.122.059435
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15372, KAKENHI-PROJECT-22K16121, KAKENHI-PROJECT-18H05278
[Journal Article] Enhancement of Regnase-1 expression with stem-loop-targeting antisense oligonucleotides alleviates inflammatory diseases2022
- Author(s)
  Ka Man Tse, Alexis Vandenbon, Xiaotong Cui, Takashi Mino, Takuya Uehata, Keiko Yasuda, Ayuko Sato, Tohru Tsujimura, Fabian Hia, Masanori Yoshinaga, Makoto Kinoshita, Tatsusada Okuno, Osamu Takeuchi
- Journal Title
  
  Science Translational Medicine
  
  Volume: In Press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H05278
[Journal Article] DSP-crosslinking and Immunoprecipitation to Isolate Weak Protein Complex2022
- Author(s)
  Akaki Kotaro、Mino Takashi、Takeuchi Osamu
- Journal Title
  
  BIO-PROTOCOL
  
  Volume: 12 Issue: 15
- DOI
  10.21769/bioprotoc.4478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H05278
[Journal Article] Enhancement of Regnase-1 expression with stem loop?targeting antisense oligonucleotides alleviates inflammatory diseases2022
- Author(s)
  Tse Ka Man、Vandenbon Alexis、Cui Xiaotong、Mino Takashi、Uehata Takuya、Yasuda Keiko、Sato Ayuko、Tsujimura Tohru、Hia Fabian、Yoshinaga Masanori、Kinoshita Makoto、Okuno Tatsusada、Takeuchi Osamu
- Journal Title
  
  Science Translational Medicine
  
  Volume: 14 Issue: 644 Pages: 1-14
- DOI
  10.1126/scitranslmed.abo2137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15372, KAKENHI-PROJECT-18H05278
[Journal Article] Extracellular mRNA transported to the nucleus exerts translation-independent function2021
- Author(s)
  Tomita Takeshi、Kato Masayoshi、Mishima Taishi、Matsunaga Yuta、Sanjo Hideki、Ito Ken-ichi、Minagawa Kentaro、Matsui Toshimitsu、Oikawa Hiroyuki、Takahashi Satoshi、Takao Toshifumi、Iwai Noriki、Mino Takashi、Takeuchi Osamu、Maru Yoshiro、Hiratsuka Sachie
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 3655-3655
- DOI
  10.1038/s41467-021-23969-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06577, KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-19H03488, KAKENHI-PROJECT-19H03500, KAKENHI-PROJECT-20K06554, KAKENHI-PROJECT-21K06868, KAKENHI-PROJECT-19H03506, KAKENHI-PROJECT-21H02438
[Journal Article] Regnase‐1-related endoribonucleases in health and immunological diseases2021
- Author(s)
  Mino Takashi、Takeuchi Osamu
- Journal Title
  
  Immunological Reviews
  
  Volume: 304 Issue: 1 Pages: 97-110
- DOI
  10.1111/imr.13023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-19H03488, KAKENHI-PROJECT-16H06279
[Journal Article] IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay2021
- Author(s)
  Akaki Kotaro、Ogata Kosuke、Yamauchi Yuhei、Iwai Noriki、Tse Ka Man、Hia Fabian、Mochizuki Atsushi、Ishihama Yasushi、Mino Takashi、Takeuchi Osamu
- Journal Title
  
  eLife
  
  Volume: 10
- DOI
  10.7554/elife.71966
- NAID
  120007166024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-19H03488, KAKENHI-PROJECT-19J23450, KAKENHI-PROJECT-20F20115, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-19H03196, KAKENHI-PLANNED-19H05678
[Journal Article] Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by regnase-12020
- Author(s)
  Nakatsuka Yoshinari、Yaku Ai、Handa Tomohiro、Vandenbon Alexis、Hikichi Yuki、Motomura Yasutaka、Sato Ayuko、Yoshinaga Masanori、Tanizawa Kiminobu、Watanabe Kizuku、Hirai Toyohiro、Chin Kazuo、Suzuki Yutaka、Uehata Takuya、Mino Takashi、Tsujimura Tohru、Moro Kazuyo、Takeuchi Osamu
- Journal Title
  
  European Respiratory Journal
  
  Volume: 57 Issue: 3 Pages: 2000018-2000018
- DOI
  10.1183/13993003.00018-2020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-18H05286, KAKENHI-PROJECT-19H03488, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-20K22737, KAKENHI-PROJECT-18K15185
[Journal Article] N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation2019
- Author(s)
  Yamasoba D, Sato K, Ichinose T, Imamura T, Koepke L, Joas S, Reith E, Hotter D, Misawa N, Akaki K, Uehata T, Mino T, Miyamoto S, Noda T, Yamashita A, Standley DM, Kirchhoff F, Sauter D, Koyanagi Y, Takeuchi O.
- Journal Title
  
  Nature Microbiology
  
  Volume: 印刷中
- NAID
  120006731123
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278
[Journal Article] N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation.2019
- Author(s)
  Yamasoba D, Sato K, Ichinose T, Imamura T, Koepke L, Joas S, Reith E, Hotter D, Misawa N, Akaki K, Uehata T, Mino T, Miyamoto S, Noda T, Yamashita A, Standley DM, Kirchhoff F, Sauter D, Koyanagi Y, Takeuchi O.
- Journal Title
  
  Nat Microbiol
  
  Volume: 4 Issue: 9 Pages: 1532-1544
- DOI
  10.1038/s41564-019-0460-3
- NAID
  120006731123
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22529, KAKENHI-PROJECT-19K22601, KAKENHI-PROJECT-18KK0447, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-17H04082, KAKENHI-PROJECT-18H02430, KAKENHI-PROJECT-18H02662, KAKENHI-PROJECT-19H03488, KAKENHI-PROJECT-17J10132, KAKENHI-PROJECT-18K15185
[Journal Article] Translation-dependent unwinding of stem?loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs2019
- Author(s)
  Mino Takashi、Iwai Noriki、Endo Masayuki、Inoue Kentaro、Akaki Kotaro、Hia Fabian、Uehata Takuya、Emura Tomoko、Hidaka Kumi、Suzuki Yutaka、Standley Daron M、Okada-Hatakeyama Mariko、Ohno Shigeo、Sugiyama Hiroshi、Yamashita Akio、Takeuchi Osamu
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 47 Pages: 8838-8859
- DOI
  10.1093/nar/gkz628
- NAID
  120006708220
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22601, KAKENHI-PROJECT-18KK0139, KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-18H02430, KAKENHI-PROJECT-19H03488, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-16H06356, KAKENHI-PROJECT-18K15185
[Journal Article] Post-transcriptional regulation of immune responses by RNA binding proteins2018
- Author(s)
  MINO Takashi、TAKEUCHI Osamu
- Journal Title
  
  Proceedings of the Japan Academy, Series B
  
  Volume: 94 Issue: 6 Pages: 248-258
- DOI
  10.2183/pjab.94.017
- NAID
  130007395766
- ISSN
  0386-2208, 1349-2896
- Year and Date
  2018-06-11
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-18H04027, KAKENHI-PROJECT-16K08832
[Journal Article] Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia2018
- Author(s)
  Nakatsuka Yoshinari、Vandenbon Alexis、Mino Takashi、Yoshinaga Masanori、Uehata Takuya、Cui Xiaotong、Sato Ayuko、Tsujimura Tohru、Suzuki Yutaka、Sato Atsuyasu、Handa Tomohiro、Chin Kazuo、Sawa Teiji、Hirai Toyohiro、Takeuchi Osamu
- Journal Title
  
  Mucosal Immunology
  
  Volume: AOP Issue: 4 Pages: 1203-1218
- DOI
  10.1038/s41385-018-0024-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16J08040, KAKENHI-PROJECT-17K08731, KAKENHI-PROJECT-18K15185, KAKENHI-PROJECT-15H05713, KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-18H04027, KAKENHI-PROJECT-18H02905, KAKENHI-PROJECT-16K08832, KAKENHI-PROJECT-16H06279
[Journal Article] Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs2017
- Author(s)
  Yoshinaga Masanori、Nakatsuka Yoshinari、Vandenbon Alexis、Ori Daisuke、Uehata Takuya、Tsujimura Tohru、Suzuki Yutaka、Mino Takashi、Takeuchi Osamu
- Journal Title
  
  Cell Reports
  
  Volume: 19 Issue: 8 Pages: 1614-1630
- DOI
  10.1016/j.celrep.2017.05.009
- NAID
  120006305989
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08832, KAKENHI-PROJECT-17K15726, KAKENHI-PROJECT-15H05713, KAKENHI-PROJECT-16H06898, KAKENHI-PROJECT-16J08040, KAKENHI-PROJECT-16H06279
[Journal Article] NSD3 keeps IRF3 active2017
- Author(s)
  Mino Takashi、Takeuchi Osamu
- Journal Title
  
  The Journal of Experimental Medicine
  
  Volume: 214 Issue: 12 Pages: 3475-3476
- DOI
  10.1084/jem.20171980
- NAID
  120006534585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08832
[Journal Article] Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis2017
- Author(s)
  Cui Xiaotong、Mino Takashi、Yoshinaga Masanori、Nakatsuka Yoshinari、Hia Fabian、Yamasoba Daichi、Tsujimura Tohru、Tomonaga Keizo、Suzuki Yutaka、Uehata Takuya、Takeuchi Osamu
- Journal Title
  
  The Journal of Immunology
  
  Volume: 199 Issue: 12 Pages: 4066-4077
- DOI
  10.4049/jimmunol.1701211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08832, KAKENHI-PROJECT-16H06898, KAKENHI-PROJECT-16J08040, KAKENHI-PROJECT-16H06279
[Journal Article] Regnase-1とRoquinによる炎症性mRNAの制御2016
- Author(s)
  三野享史
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 65 Pages: 180-184
- NAID
  130005156510
- Data Source
  KAKENHI-PROJECT-16K08832
[Journal Article] Regnase-1とRoquinによる炎症性mRNAの制御2016
- Author(s)
  三野享史, 竹内理
- Journal Title
  
  医学のあゆみ
  
  Volume: 257 Pages: 180-182
- NAID
  130005156510
- Data Source
  KAKENHI-PROJECT-16K08832
[Journal Article] Regnase-1とRoquinによる炎症性mRNAの制御2016
- Author(s)
  三野享史, 竹内理
- Journal Title
  
  日薬理誌特集
  
  Volume: 147 Pages: 351-356
- NAID
  130005156510
- Data Source
  KAKENHI-PROJECT-16K08832
[Journal Article] 免疫研究におけるRNA-Seq システム免疫学へのアプローチ2016
- Author(s)
  三野享史, 竹内理
- Journal Title
  
  実験医学別冊 NGSアプリケーション RNA-Seq実験ハンドブック
  
  Volume: NA Pages: 197-203
- Data Source
  KAKENHI-PROJECT-16K08832
[Journal Article] Regnase-1 and Roquin regulate a common element in inflammatory mRNAs by spatiotemporally distinct mechanisms2015
- Author(s)
  Takashi Mino, Yasuhiro Murakawa, Akira Fukao, Alexis Vandenbon, Hans-Hermann Wessels, Daisuke Ori, Takuya Uehata, Sarang Tartey, Shizuo Akira, Yutaka Suzuki, Carola G. Vinuesa, Uwe Ohler, Daron M. Standley, Markus Landthaler, Toshinobu Fujiwara, Osamu Takeuchi.
- Journal Title
  
  Cell
  
  Volume: XX
- NAID
  120005608042
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860355
[Journal Article] Inhibition of DNA replication of human papillomavirus by using zinc finger-single-chain FokI dimer hybrid2014
- Author(s)
  Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera
- Journal Title
  
  Molecular Biotechnology
  
  Volume: 56 Issue: 8 Pages: 731-737
- DOI
  10.1007/s12033-014-9751-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860355
[Journal Article] Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex2014
- Author(s)
  Sarang Tartey, Kazufumi Matsushita, Alexis Vandenbon, Daisuke Ori, Tomoko Imamura, Takashi Mino, Daron M. Standley, Jules A. Hoffmann, Jean-Marc Reichhart, Shizuo Akira, Osamu Takeuchi
- Journal Title
  
  The EMBO Journal
  
  Volume: 33 Issue: 20 Pages: 2332-2348
- DOI
  10.15252/embj.201488447
- NAID
  120005649311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860355, KAKENHI-PROJECT-26860340
[Journal Article] Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation2013
- Author(s)
  Uehata T, Iwasaki H, Vandenbon A, Matsushita, K, Hernandez Cuellar E, Kuniyoshi K, Satoh T, Mino T, Suzuki Y, Standley DM, Tsujimura T, Rakugi H, Isaka Y, Takeuchi O and Akira S
- Journal Title
  
  Cell
  
  Volume: 23;153 Issue: 5 Pages: 1036-49
- DOI
  10.1016/j.cell.2013.04.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689016, KAKENHI-PROJECT-24790484, KAKENHI-PROJECT-25860355
[Journal Article] Critical Role of AZI2 in GM-CSF-Induced Dendritic Cell Differentiation2013
- Author(s)
  Fukasaka M, Ori D, Kawagoe T, Uematsu S, Maruyama K, Okazaki T, Kozaki T, Imamura T, Tartey S, Mino T, Satoh T, Akira S, Takeuchi O
- Journal Title
  
  J Immunol
  
  Volume: 190 Issue: 11 Pages: 5702-11
- DOI
  10.4049/jimmunol.1203155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689016, KAKENHI-PROJECT-24590582, KAKENHI-PROJECT-25860355
[Journal Article] Gene- and protein-delivered zinc finger–staphylococcal nuclease hybrid for inhibition of DNA replication of human papillomavirus2013
- Author(s)
  Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 2 Pages: e56633-e56633
- DOI
  10.1371/journal.pone.0056633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860355
[Journal Article] Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo.2013
- Author(s)
  Kazuya Masuda, Barry Ripley, Riko Nishimura, Takashi Mino, Osamu Takeuchi, Go Shioi, Hiroshi Kiyonari, and Tadamitsu Kishimoto
- Journal Title
  
  Proceeding of the National Academy of Sciences of the United States of America
  
  Volume: 110 Issue: 23 Pages: 9409-9414
- DOI
  10.1073/pnas.1307419110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J00896, KAKENHI-PROJECT-24659824, KAKENHI-PROJECT-25293378, KAKENHI-PROJECT-25860355
[Journal Article] Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation2013
- Author(s)
  Takashi Mino, Osamu Takeuchi
- Journal Title
  
  Biotechnology and Genetic Engineering
  
  Volume: 29 Issue: 1 Pages: 49-60
- DOI
  10.1080/02648725.2013.801236
- NAID
  120005474488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860355
[Journal Article] Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activaion via MAPKs.2013
- Author(s)
  Ori D
- Journal Title
  
  J Immunol
  
  Volume: 190(8) Issue: 8 Pages: 4037-4045
- DOI
  10.4049/jimmunol.1300173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20002008, KAKENHI-PROJECT-22689016, KAKENHI-PROJECT-23790438, KAKENHI-PROJECT-25860355
[Patent] SMG1阻害剤による免疫操作2017
- Inventor(s)
  竹内理，三野享史，山下暁朗
- Industrial Property Rights Holder
  竹内理，三野享史，山下暁朗
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-199591
- Filing Date
  2017
- Acquisition Date
  2017
- Data Source
  KAKENHI-PROJECT-16K08832
[Presentation] RNA structure profiling reveals differential accessibility of regulatory RBPs in responses to immune stimulation2022
- Author(s)
  Mino T, Hia F, Akaki K, Takeuchi O
- Organizer
  第23回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Clues to reveal the mechanism underlying Regnase-1-mRNA binding2022
- Author(s)
  Akaki K, Li W, Mino T, Takeuchi O
- Organizer
  第9 回CCR4-NOT研究会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] 14-3-3-mediated regulatory mechanism of Regnase-1 under inflammatory stimulation2022
- Author(s)
  赤木宏太朗, 小形公亮, 三野享史, 石濱泰, 竹内理
- Organizer
  第23回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] The 5′ untranslated region of Regnase-1 mRNA mediates protein translation through structure to regulate immune response2022
- Author(s)
  Li W, Akaki K, Mino T, and Takeuchi O
- Organizer
  第9 回CCR4-NOT研究会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Manipulating the expressions of Regnase-1 by stem-loop-targeting-antisense oligonucleotides to counteract inflammatory diseases2021
- Author(s)
  Ka Man Tse, Xiaotong Cui, Alexis Vandenbon, Takashi Mino, Takuya Uehata, Keiko Yasuda, Ayuko Sato, Tohru Tsujimura, Fabian Hia, Masanori Yoshinaga, Osamu Takeuchi
- Organizer
  第44回日本分子生物学年会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Manipulation of Regnase-1 mRNA stability by morpholino-based antisense oligonucleotides alleviates inflammatory responses in pulmonary and autoimmune diseases2021
- Author(s)
  Ka Man Tse, Xiaotong Cui, Alexis Vandenbon, Keiko Yasuda, Takuya Uehata, Ayuko Sato, Tohru Tsujimura, Takashi Mino, Masanori Yoshinaga, Tatsusada Okuno, Yoshinari Nakatsuka, Osamu Takeuchi
- Organizer
  第22回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] 炎症におけるRNA制御の分子基盤2021
- Author(s)
  三野享史
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03488
[Presentation] RNA structure profiling reveals differential accessibility to regulatory RBPs in responses to immune stimulation2021
- Author(s)
  三野享史
- Organizer
  第8 回CCR4-NOT研究会
- Data Source
  KAKENHI-PROJECT-19H03488
[Presentation] 炎症におけるRNA制御の分子基盤2021
- Author(s)
  三野享史
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Manipulating the expression of Regnase-1 by antisense oligonucleoties to counteract inflammatory diseases2021
- Author(s)
  Ka Man Tse, Takashi Mino, Takuya Uehata, Keiko Yasuda, Masanori Yoshinaga, Osamu Takeuchi
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Regnase-1による炎症性mRNA分解機構2019
- Author(s)
  三野享史
- Organizer
  第7回CCR4-NOT研究会
- Data Source
  KAKENHI-PROJECT-19H03488
[Presentation] Regnase-1による炎症性mRNA分解機構2019
- Author(s)
  三野享史
- Organizer
  第7 回CCR4-NOT研究会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Unwinding of stem-loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs2019
- Author(s)
  Mino Takashi、Takeuchi Osamu
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03488
[Presentation] Unwinding of stem-loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs.2019
- Author(s)
  Takashi Mino, Osamu Takeuchi
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] SMG1はRegnase-1経路を介して炎症性mRNAを制御する2018
- Author(s)
  三野享史，岩井紀貴，赤木宏太朗，山下暁朗，竹内理
- Organizer
  第20回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] 鉄代謝を制御する転写後調節機構の解明2018
- Author(s)
  吉永正憲，三野享史，Bassik, M. C.，竹内理
- Organizer
  第20回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-16K08832
[Presentation] Regnase-1は鉄代謝関連のmRNAを分解することで鉄恒常性を維持する2018
- Author(s)
  吉永正憲，三野享史，竹内理
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K08832
[Presentation] SMG1はRegnase-1経路を介して炎症性mRNAを制御する2018
- Author(s)
  三野享史，岩井紀貴，赤木宏太朗，山下暁朗，竹内理
- Organizer
  第20回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-16K08832
[Presentation] 鉄代謝を制御する転写後調節機構の解明2018
- Author(s)
  吉永正憲，三野享史，Bassik, M. C.，竹内理
- Organizer
  第20回日本RNA学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Regnase-1は鉄代謝関連のmRNAを分解することで鉄恒常性を維持する2018
- Author(s)
  吉永正憲，三野享史，竹内理
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] The ribonuclease Regnase-1 maintains iron homeostasis via the destabilization of iron-regulatory transcripts2018
- Author(s)
  Yoshinaga, M., Mino, T., and Takeuchi, O
- Organizer
  RNA2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08832
[Presentation] Regnase-1による炎症性mRNA分解機構2018
- Author(s)
  三野享史
- Organizer
  第6回CCR4-NOT研究会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] The ribonuclease Regnase-1 maintains iron homeostasis via the destabilization of iron-regulatory transcripts.2018
- Author(s)
  Yoshinaga, M., Mino, T., and Takeuchi, O.
- Organizer
  RNA2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Regnase-1による炎症性mRNA分解機構2018
- Author(s)
  三野享史
- Organizer
  第6回CCR4-NOT研究会
- Data Source
  KAKENHI-PROJECT-16K08832
[Presentation] SMG1はRegnase-1経路を介して炎症性mRNAを制御する2017
- Author(s)
  三野享史，岩井紀貴，赤木宏太朗，山下暁朗，竹内理
- Organizer
  第19 回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-16K08832
[Presentation] Post-transcriptional regulation of inflammation-related mRNAs by Regnase-12017
- Author(s)
  Takashi Mino
- Organizer
  The 12th International Symposium of the Institute Network -Driving Next-Generation Medicine: the Spirit of Pioneering Discovery in Medical Science-
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08832
[Presentation] Regnase-1 regulates inflammation-related mRNAs during pioneer rounds of translation2017
- Author(s)
  Takashi Mino, Osamu Takeuchi
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08832
[Presentation] The ribonuclease Regnase-1 plays a critical role in iron homeostasis and anemia.2016
- Author(s)
  Yoshinaga, M., Mino, T., and Takeuchi, O.
- Organizer
  2016 Annual Meeting of Japanese Society for Immunology.
- Place of Presentation
  Ginowan City, Japan
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08832
[Presentation] The ribonuclease Regnase-1 plays a role in iron homeostasis and anemia.2016
- Author(s)
  Yoshinaga, M., Mino, T., and Takeuchi, O.
- Organizer
  International Congress of Immunology 2016.
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08832
[Presentation] A pivotal role of Regnase-1 at the airway epithelium for the protection against pathogens through the enhancement of IgA secretion.2016
- Author(s)
  Nakatsuka, Y., Mino, T., and Takeuchi, O.
- Organizer
  2016 Annual Meeting of Japanese Society for Immunology.
- Place of Presentation
  Ginowan City, Japan
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08832
[Presentation] Regnase-1 and Roquin regulate a common element in inflammatory mRNAs by spatiotemporally distinct mechanisms.2016
- Author(s)
  Mino, T.
- Organizer
  The 23rd East Asia Joint Symposium.
- Place of Presentation
  Taipei City, Taiwan
- Year and Date
  2016-10-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08832
[Presentation] Post-transcriptional regulation of inflammation-related mRNAs by Regnase-1 and Roquin.2016
- Author(s)
  Mino, T.
- Organizer
  The 15th Awaji International Forum on Infection and Immunity.
- Place of Presentation
  Awaji, Japan
- Year and Date
  2016-09-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08832
[Presentation] Post-transcriptional regulation of inflammation-related mRNAs by Regnase-1.2016
- Author(s)
  Mino, T., and Takeuchi, O.
- Organizer
  2016 Annual Meeting of Japanese Society for Immunology.
- Place of Presentation
  Ginowan City, Japan
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08832
[Presentation] Regnase-1 標的mRNA 配列の網羅的同定
- Author(s)
  阿部壮岐，三野享史，村川泰裕，竹内理
- Organizer
  RNAフロンティアミーティング2014
- Place of Presentation
  和歌山県西牟婁郡白浜町
- Year and Date
  2014-09-16 – 2014-09-18
- Data Source
  KAKENHI-PROJECT-25860355
[Presentation] Regnase-1は翻訳に依存して炎症関連mRNAを分解する
- Author(s)
  三野享史，深尾亜喜良，藤原俊伸，竹内理
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25860355
[Presentation] 自然免疫応答の転写後調節におけるRegnase-1 の作用機構
- Author(s)
  三野享史
- Organizer
  名古屋市立大学大学院薬学研究科藤原研究室セミナー
- Place of Presentation
  名古屋市立大学田辺通キャンパス(愛知県名古屋市)
- Invited
- Data Source
  KAKENHI-PROJECT-25860355
[Presentation] 自然免疫応答の転写後調節におけるRegnase-1 の作用機構
- Author(s)
  三野享史
- Organizer
  日本化学会北海道支部　平成25年度室蘭・苫小牧地区化学講演会
- Place of Presentation
  苫小牧工業高等専門学校(北海道苫小牧市)
- Invited
- Data Source
  KAKENHI-PROJECT-25860355
[Presentation] Regnase-1 destabilizes inflammationrelated mRNAs in a translation-dependent manner
- Author(s)
  Takashi Mino, Osamu Takeuchi
- Organizer
  2014 Annual Meeting of Japanese Society for Immunology
- Place of Presentation
  京都府京都市
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25860355
[Presentation] A novel role of Regnase-1 in the iron homeostasis and anemia
- Author(s)
  Masanori Yoshinaga, Takashi Mino, Osamu Takeuchi
- Organizer
  2014 Annual Meeting of Japanese Society for Immunology
- Place of Presentation
  京都府京都市
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25860355
[Presentation] 炎症の転写後調節におけるRegnase-1の作用機構
- Author(s)
  三野享史
- Organizer
  新学術領域「ゲノム支援」2014年度拡大班会議
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2014-08-20 – 2014-08-21
- Data Source
  KAKENHI-PROJECT-25860355
[Presentation] Regnase-1の作用機構から探る自然免疫応答における転写後調節の解明
- Author(s)
  三野享史
- Organizer
  新学術領域「ゲノム支援」2013年度拡大班会議
- Place of Presentation
  神戸ポートピアホテル(兵庫県神戸市)
- Data Source
  KAKENHI-PROJECT-25860355
[Presentation] Regnase-1 destabilizes inflammation-related mRNAs in a translation-dependent manner
- Author(s)
  Takashi Mino, Akira Fukao, Toshinobu Fujiwara, Osamu Takeuchi,
- Organizer
  RNA 2014 NAGOYA, The 16th RNA meeting of the RNA Society of Japan
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2014-07-23 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-25860355

1. Takeuchi Osamu (10379092)

# of Collaborated Projects: 2 results

# of Collaborated Products: 36 results
2. 植畑拓也 (50785970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. Yoshinaga Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 今見考志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 野田岳志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 山下暁朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 小井川浩之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mino Takashi 三野 享史

MINO Takashi 三野 享史

Research Projects

Research Products

Co-Researchers

Molecular basis of translational regulation in immune systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of mRNA translation in immune systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of immune regulatory mechanisms mediated by mRNA metabolism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of UPF1-mediated mRNA regulation in immune systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of posttranscriptional mechanisms of Regnase-1-mediated mRNA decay in innate immune systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Cyclin J-CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhancement of Regnase-1 expression with stem-loop-targeting antisense oligonucleotides alleviates inflammatory diseases2022

Author(s)

Journal Title

Data Source

[Journal Article] DSP-crosslinking and Immunoprecipitation to Isolate Weak Protein Complex2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhancement of Regnase-1 expression with stem loop?targeting antisense oligonucleotides alleviates inflammatory diseases2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular mRNA transported to the nucleus exerts translation-independent function2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regnase‐1-related endoribonucleases in health and immunological diseases2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by regnase-12020

Author(s)

Journal Title

DOI

Data Source

Mino Takashi 三野享史

MINO Takashi 三野享史