Hattori Yorito 服部頼都

Researcher Number	60713849
Other IDs	https://orcid.org/0000-0002-1495-4433
Affiliation (Current)	2026: 国立研究開発法人国立循環器病研究センター, 病院, 特任部長
Affiliation (based on the past Project Information) *help	2026: 国立研究開発法人国立循環器病研究センター, 病院, 特任部長 2023 – 2024: 国立研究開発法人国立循環器病研究センター, 病院, 特任部長 2021 – 2022: 国立研究開発法人国立循環器病研究センター, 病院, 医長 2015: 国立研究開発法人国立循環器病研究センター, 病院, 客員研究員 2014: 独立行政法人国立循環器病研究センター, その他部局等, 研究員 2013 – 2014: 独立行政法人国立循環器病研究センター, 研究所, 流動研究員
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Basic Section 57020:Oral pathobiological science-related / Nerve anatomy/Neuropathology / General internal medicine(including psychosomatic medicine) Except Principal Investigator Basic Section 57080:Social dentistry-related
Keywords	Principal Investigator SIRT1 / 女性 / APOE4 / アルツハイマー病 / 脳小血管病 / 脳卒中 / 脳微小出血 / Streptococcus mutans / 齲蝕原生細菌 / Bリピート … More / 脳内出血 / Stereptococcus mutans / Cnm / 脱アセチル化 / 内皮型一酸化窒素合成酵素 / 脳虚血 / 脳低還流 / 脳血流量 / 血管性認知症 / 頸動脈狭窄症 … More Except Principal Investigator Streptococcus mutans / 脳微小出血 / Cnm蛋白 / S.mutans / 口腔内細菌 / 脳小血管病 / 微小出血 / 脳出血 Less

APOE4バリアントよるneurovascular dysfunction：アルツハイマー病の病態機序の解明Principal Investigator
- Principal Investigator
  
  服部頼都
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  National Cardiovascular Center Research Institute
コラーゲン結合蛋白陽性齲蝕原性細菌が誘導する脳出血重症化メカニズムの解明
- Principal Investigator
  
  阿部宗一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  National Cardiovascular Center Research Institute
Investigation of pathomechanism of cerebral microbleeds in collagen-binding protein-producing cariogenic bacteriaPrincipal Investigator
- Principal Investigator
  
  Hattori Yorito
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  National Cardiovascular Center Research Institute
Establishment of novel prophylaxis/treatment for cerebral infarction using SIRT1 activatorPrincipal Investigator
- Principal Investigator
  
  Hattori Yorito
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  National Cardiovascular Center Research Institute
SIRT1の脳虚血抵抗性機構の検討Principal Investigator
- Principal Investigator
  
  服部頼都
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  National Cardiovascular Center Research Institute

All 2024 2023 2022 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 脳卒中―新時代の治療を求めて「SIRT1」2016
- Author(s)
  服部頼都，猪原匡史
- Total Pages
  6
- Publisher
  日本臨牀
- Data Source
  KAKENHI-PROJECT-26640034
[Journal Article] Harboring Cnm‐expressing <i>Streptococcus mutans</i> in the oral cavity relates to both deep and lobar cerebral microbleeds2023
- Author(s)
  Ikeda Shuhei、Saito Satoshi...
- Journal Title
  
  European Journal of Neurology
  
  Volume: - Issue: 11 Pages: 3487-3496
- DOI
  10.1111/ene.15720
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16944, KAKENHI-PROJECT-21H03149, KAKENHI-PROJECT-20K07890, KAKENHI-PROJECT-21K16961, KAKENHI-PROJECT-20H04047
[Journal Article] Risk Assessment of Cnm-positive Streptococcus Mutans in Stroke Survivors (RAMESSES): Protocol for a Multicenter Prospective Cohort Study2022
- Author(s)
  Satoshi Hosoki, Yorito Hattori, Satoshi Saito, Misa Takegami, Shuichi Tonomura, Yumi Yamamoto, Shuhei Ikeda, Naohisa Hosomi, Naoya Oishi, Yoshiaki Morita, Yoshihiro Miyamoto, Ryota Nomura, Kazuhiko Nakano, Masafumi Ihara
- Journal Title
  
  Frontiers in Neurology
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16961
[Journal Article] Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans.2016
- Author(s)
  Hattori Y, Enmi J, Iguchi S, Saito S, Yamamoto Y, Tsuji M, Nagatsuka K, Kalaria RN, Iida H, Ihara M
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 5 Issue: 2
- DOI
  10.1161/jaha.115.002757
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461867, KAKENHI-PROJECT-15H04271, KAKENHI-PROJECT-26640034
[Journal Article] SIRT1 attenuates severe ischemic damage by preserving cerebral blood flow.2015
- Author(s)
  Hattori Y, Okamoto Y, Nagatsuka K, Takahashi R, Kalaria RN, Kinoshita M, Ihara M
- Journal Title
  
  NeuroReport
  
  Volume: 26 Issue: 3 Pages: 113-117
- DOI
  10.1097/wnr.0000000000000308
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25640031, KAKENHI-PROJECT-26640034, KAKENHI-PLANNED-23111002
[Journal Article] Silent Information Regulator 2 Homolog 1 Counters Cerebral Hypoperfusion Injury by Deacetylating Endothelial Nitric Oxide Synthase2014
- Author(s)
  Hattori Y, Okamoto Y, Maki T, Yamamoto Y, Oishi N, Yamahara K, Nagatsuka K, Takahashi R, Kalaria RN, Fukuyama H, Kinoshita M, Ihara M
- Journal Title
  
  Stroke
  
  Volume: 45 Issue: 11 Pages: 3403-3411
- DOI
  10.1161/strokeaha.114.006265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390292, KAKENHI-PROJECT-24791296, KAKENHI-PROJECT-25640031, KAKENHI-PROJECT-26640034, KAKENHI-PROJECT-22220003
[Presentation] 脳微小出血保有者におけるCnm陽性Streptococcus mutansの　保有と年齢との関連2024
- Author(s)
  山本晃匡, 服部頼都, 阿部宗一郎, 細木聡, 中澤晋作, 殿村修一, 齊藤聡, 竹上未紗, 仲野和彦, 猪原匡史
- Organizer
  第42回The Mt. Fuji workshop on CVD
- Data Source
  KAKENHI-PROJECT-24K13256
[Presentation] Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans2016
- Author(s)
  Hattori Y, Enmi J, Okamoto Y, Nagatsuka K, Kalaria RN, Iida H, Ihara M
- Organizer
  International Stroke Conference 2016
- Place of Presentation
  Los Angeles
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26640034
[Presentation] 緩徐進行性の脳血流低下による血管性認知障害モデルマウスの作製2015
- Author(s)
  服部頼都，圓見純一郎，長束一行，飯田秀博，猪原匡史
- Organizer
  第27回日本脳循環代謝学会総会
- Place of Presentation
  富山
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-26640034
[Presentation] SIRT1は脳虚血抵抗性に賦与する2014
- Author(s)
  服部　頼都
- Organizer
  日本脳卒中学会総会
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-25893301
[Presentation] SIRT1 plays a potent protective role against chronic cerebral hypoperfusion2013
- Author(s)
  服部　頼都
- Organizer
  Society for Neuroscience 2013
- Place of Presentation
  The San Diego Convention Center
- Data Source
  KAKENHI-PROJECT-25893301
[Presentation] SIRT1は脳虚血抵抗性に賦与する2013
- Author(s)
  服部　頼都
- Organizer
  日本脳循環代謝学会総会
- Place of Presentation
  京王プラザホテル札幌
- Data Source
  KAKENHI-PROJECT-25893301
[Presentation] A POTENT PROTECTIVE ROLE OF SIRT1 AGAINST CHRONIC CEREBRAL HYPOPERFUSION
- Author(s)
  Hattori Y, Okamoto Y, Yamamoto Y, Oishi N, Nagatsuka K, Takahashi R, Fukuyama H, Kinoshita M, Ihara M
- Organizer
  第55回日本神経学会学術集会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26640034

1. 阿部宗一郎 (90971838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. OISHI Naoya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. ENMI Jyunichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 猪原匡史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 齊藤聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 福山秀直

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hattori Yorito 服部 頼都

Research Projects

Research Products

Co-Researchers

APOE4バリアントよるneurovascular dysfunction：アルツハイマー病の病態機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

コラーゲン結合蛋白陽性齲蝕原性細菌が誘導する脳出血重症化メカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of pathomechanism of cerebral microbleeds in collagen-binding protein-producing cariogenic bacteriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of novel prophylaxis/treatment for cerebral infarction using SIRT1 activatorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

SIRT1の脳虚血抵抗性機構の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 脳卒中―新時代の治療を求めて「SIRT1」2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Harboring Cnm‐expressing <i>Streptococcus mutans</i> in the oral cavity relates to both deep and lobar cerebral microbleeds2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Risk Assessment of Cnm-positive Streptococcus Mutans in Stroke Survivors (RAMESSES): Protocol for a Multicenter Prospective Cohort Study2022

Author(s)

Journal Title

Data Source

[Journal Article] Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SIRT1 attenuates severe ischemic damage by preserving cerebral blood flow.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Silent Information Regulator 2 Homolog 1 Counters Cerebral Hypoperfusion Injury by Deacetylating Endothelial Nitric Oxide Synthase2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] 脳微小出血保有者におけるCnm陽性Streptococcus mutansの 保有と年齢との関連2024

Author(s)

Organizer

Data Source

[Presentation] Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 緩徐進行性の脳血流低下による血管性認知障害モデルマウスの作製2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] SIRT1は脳虚血抵抗性に賦与する2014

Hattori Yorito 服部頼都

[Presentation] 脳微小出血保有者におけるCnm陽性Streptococcus mutansの　保有と年齢との関連2024