Arai Kenta 荒井堅太

Researcher Number	60728062
Other IDs	https://orcid.org/0000-0003-0785-2559
Affiliation (Current)	2024: 東海大学, 理学部, 准教授
Affiliation (based on the past Project Information) *help	2023: 東海大学, 理学部, 講師 2017 – 2019: 東海大学, 理学部, 講師 2014 – 2015: 東海大学, 理学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry / Chemical biology / Bio-related chemistry
Keywords	Principal Investigator タンパク質 / フォールディング / ジスルフィド / 分子認識 / 酸化還元 / シャペロン / 抗酸化活性 / 抗酸化剤 / ジセレニド / セレネニルスルフィド … More / 酵素モデル / 酸化ストレス / 創薬 / 神経変性疾患 / 酸化還元反応 / タンパク質フォールディング / セレン / ジスルフィド結合 / リゾチーム / インスリン / フローケミストリー / マイクロリアクター Less

Development of a method to control protein structure by redox-active molecules including chaperone-like activityPrincipal Investigator
- Principal Investigator
  
  荒井堅太
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Tokai University
Development and pharmacological investigation of novel diselenide compounds as a medicine for folding diseasesPrincipal Investigator
- Principal Investigator
  
  Arai Kenta
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  Tokai University
Development of an effective folding procedure for SS-containing proteins by using a micro flow chemistryPrincipal Investigator
- Principal Investigator
  
  Arai Kenta
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Bio-related chemistry
- Research Institution
  Tokai University

All 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Oxidative Protein Folding Using trans-3,4-Dihydroxyselenolane Oxide2019
- Author(s)
  Arai Kenta、Iwaoka Michio
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 1967 Pages: 229-244
- DOI
  10.1007/978-1-4939-9187-7_14
- ISBN
  9781493991860, 9781493991877
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K05792, KAKENHI-PROJECT-17K18123
[Journal Article] Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding2019
- Author(s)
  Shunsuke Okada, Motonori Matsusaki, Kenta AraiK , Yuji Hidaka, Kenji Inaba, Masaki Okumura, Takahiro Muraoka
- Journal Title
  
  Chemical Communications
  
  Volume: 55(6) Issue: 6 Pages: 759-762
- DOI
  10.1039/c8cc08657e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K01925, KAKENHI-PROJECT-17K18123, KAKENHI-PUBLICLY-17H05147, KAKENHI-PUBLICLY-17H05868, KAKENHI-PROJECT-17H04885, KAKENHI-PROJECT-17K15098, KAKENHI-PROJECT-18H03978, KAKENHI-PLANNED-26116005
[Journal Article] Cyclic telluride reagents with remarkable glutathione peroxidase-like activity for purification-free synthesis of highly pure organodisulfides2019
- Author(s)
  Arai Kenta、Osaka Yuui、Haneda Masahiro、Sato Yuumi
- Journal Title
  
  Catalysis Science & Technology
  
  Volume: 9 Issue: 14 Pages: 3647-3655
- DOI
  10.1039/c9cy00562e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K18123
[Journal Article] Modeling Thioredoxin Reductase‐Like Activity with Cyclic Selenenyl Sulfides: Participation of an NH???Se Hydrogen Bond through Stabilization of the Mixed Se?S Intermediate2019
- Author(s)
  Arai Kenta、Matsunaga Takahiko、Ueno Haruhito、Akahoshi Nozomi、Sato Yuumi、Chakrabarty Gaurango、Mugesh Govindasamy、Iwaoka Michio
- Journal Title
  
  Chemistry ? A European Journal
  
  Volume: 25 Issue: 55 Pages: 12751-12760
- DOI
  10.1002/chem.201902230
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K05792, KAKENHI-PROJECT-17K18123
[Journal Article] インスリンの簡便な化学合成法の開発─未来の糖尿病治療への期待2018
- Author(s)
  荒井堅太、岩岡道夫
- Journal Title
  
  化学
  
  Volume: 73 Pages: 29-33
- NAID
  40021682274
- Data Source
  KAKENHI-PROJECT-17K18123
[Journal Article] Rapid Electrochemical Conversion of Thiol and Disulfide into Difluoroand Trifluoromethyl Thioethers in a Microfluidic Reactor2018
- Author(s)
  Arai Kenta、Ueda Setsura、Tamura Sayaka
- Journal Title
  
  Curr. Green Chem.
  
  Volume: 4 Issue: 3 Pages: 137-143
- DOI
  10.2174/2213346105666171206150931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K18123
[Journal Article] インスリン製剤の簡便な化学合成への展開2018
- Author(s)
  荒井堅太、岩岡道夫
- Journal Title
  
  Farumashia
  
  Volume: 54 Issue: 12 Pages: 1135-1139
- DOI
  10.14894/faruawpsj.54.12_1135
- NAID
  130007539483
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-17K18123
[Journal Article] Characterization and optimization of two-chain folding pathways of insulin via native chain assembly2018
- Author(s)
  Arai Kenta、Takei Toshiki、Shinozaki Reina、Noguchi Masato、Fujisawa Shouta、Katayama Hidekazu、Moroder Luis、Ando Setsuko、Okumura Masaki、Inaba Kenji、Hojo Hironobu、Iwaoka Michio
- Journal Title
  
  Communications Chemistry
  
  Volume: 1 Issue: 1 Pages: 26-26
- DOI
  10.1038/s42004-018-0024-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K05792, KAKENHI-PROJECT-17K18123, KAKENHI-PUBLICLY-17H05868, KAKENHI-PROJECT-18H03978, KAKENHI-PROJECT-16H04180, KAKENHI-PROJECT-17K15098
[Journal Article] Mechanism of radioprotection by dihydroxy-1-selenolane (DHS): Effect of fatty acid conjugation and role of glutathione peroxidase (GPx)2018
- Author(s)
  Verma Prachi、Kunwar Amit、Arai Kenta、Iwaoka Michio、Priyadarsini K. Indira
- Journal Title
  
  Biochimie
  
  Volume: 144 Pages: 122-133
- DOI
  10.1016/j.biochi.2017.10.021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K05792, KAKENHI-PROJECT-17K18123
[Journal Article] Selenoglutathione Diselenide: Unique Redox Reactions in the GPx-Like Catalytic Cycle and Repairing of Disulfide Bonds in Scrambled Protein2017
- Author(s)
  Shimodaira Shingo、Asano Yuki、Arai Kenta、Iwaoka Michio
- Journal Title
  
  Biochemistry
  
  Volume: 56 Issue: 42 Pages: 5644-5653
- DOI
  10.1021/acs.biochem.7b00751
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K05792, KAKENHI-PROJECT-17K18123
[Journal Article] Protein Folding in the Presence of Water-Soluble Cyclic Diselenides with Novel Oxidoreductase and Isomerase Activities2017
- Author(s)
  Arai Kenta、Ueno Haruhito、Asano Yuki、Chakrabarty Gaurango、Shimodaira Shingo、Mugesh Govindasamy、Iwaoka Michio
- Journal Title
  
  ChemBioChem
  
  Volume: 19 Issue: 3 Pages: 207-211
- DOI
  10.1002/cbic.201700624
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K05792, KAKENHI-PROJECT-17K18123
[Journal Article] Preparation of Selenoinsulin as a Long-Lasting Insulin Analogue2017
- Author(s)
  Kenta Arai+, Toshiki Takei+, Masaki Okumura+, Satoshi Watanabe+, Yuta Amagai, Yuya Asahina, Luis Moroder, Hironobu Hojo, Kenji Inaba, and Michio Iwaoka
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 印刷中 Issue: 20 Pages: 5522-5526
- DOI
  10.1002/anie.201701654
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04180, KAKENHI-PROJECT-17K05792, KAKENHI-PROJECT-17K15098, KAKENHI-PROJECT-17K18123, KAKENHI-PUBLICLY-17H05868, KAKENHI-PROJECT-15H04335, KAKENHI-PLANNED-26116005
[Journal Article] Tetrahydroselenophene. A Unique Structural Motif for Biochemical Applications2016
- Author(s)
  Kenta Arai, Michio Iwaoka
- Journal Title
  
  Current Organic Chemistry
  
  Volume: 20 Issue: 2 Pages: 155-165
- DOI
  10.2174/1385272819666150724233306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26888016
[Journal Article] Alkyl chain modulated cytotoxicity and antioxidant activity of bioinspired amphiphilic selenolanes2016
- Author(s)
  Prachi Verma, Amit Kunwar, Kenta Arai, Michio Iwaoka, K. Indira Priyadarsini
- Journal Title
  
  Toxicology Research
  
  Volume: 5 Issue: 2 Pages: 434-445
- DOI
  10.1039/c5tx00331h
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26888016
[Journal Article] Fatty acid conjugates of water-soluble trans-3,4-dihydroxy-1-selenolane. Effect of an alkyl chain length on the antioxidant capacity2015
- Author(s)
  Michio Iwaoka, Nobukazu Sano, Ying-Yin Lin, Arisa Katakura, Masato Noguchi, Kohei Takahashi, Fumio Kumakura, Kenta Arai, Beena G. Singh, Amit Kunwar, K. Indira Priyadarsini
- Journal Title
  
  ChemBioChem
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26888016
[Journal Article] Effects of Ring Size and Polar Functional Groups on the Glutathione Peroxidase-Like Antioxidant Activity of Water-Soluble Cyclic Selenides2015
- Author(s)
  Kenta Arai, Fumio Kumakura, Motoi Takahira, Natsumi Sekiyama, Nozomi Kuroda, Toshiki Suzuki, Michio Iwaoka
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 5 Issue: 11 Pages: 5633-5642
- DOI
  10.1021/acs.joc.5b00544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26888016
[Journal Article] An Amphiphilic Selenide Catalyst Behaves Like a Hybrid Mimic of Protein Disulfide Isomerase and Glutathione Peroxidase 72014
- Author(s)
  Kenta Arai, Kenji Moriai, Akinobu Ogawa, Michio Iwaoka
- Journal Title
  
  Chemistry-An Asian Journal
  
  Volume: 9 Issue: 12 Pages: 3464-3471
- DOI
  10.1002/asia.201402726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26888016
[Presentation] Synthesis and applications of water-soluble organochalcogen compounds as an oxidoreductase mimic2019
- Author(s)
  Arai Kenta
- Organizer
  8th workshop of the multidisciplinary group SeS Redox & catalysis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18123
[Presentation] 酸化的フォールディングと脱ニトロソ化反応の両方を促進する新規ジセレニド化合物の合成と生物応用2019
- Author(s)
  塚越俊介、上野陽士、浅野友紀、荒井堅太
- Organizer
  第5回日本セレン研究会
- Data Source
  KAKENHI-PROJECT-17K18123
[Presentation] Cyclic selenides and tellurides with remarkable GPx-like activity for purification-free synthesis of highly pure organodisulfides2019
- Author(s)
  Arai Kenta、Osaka Yuui
- Organizer
  14th International Conference on the Chemistry of Selenium and Tellurium (ICCST-14)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18123
[Presentation] 有機-水層セグメントマイクロフローにおける環状テルリド化合物の高いGPx様活性を利用した高純度有機ジスルフィド化合物の生成2019
- Author(s)
  荒井堅太、大坂侑意、羽田将弘、佐藤友海
- Organizer
  第46回有機典型元素化学討論会
- Data Source
  KAKENHI-PROJECT-17K18123
[Presentation] アミノ基を有する水溶性環状セレネニルスルフィド化合物のチオレドキシンリダクターゼ様活性2019
- Author(s)
  松永峻彦、上野陽士、赤星希望、佐藤友海、岩岡道夫、荒井堅太
- Organizer
  第5回日本セレン研究会
- Data Source
  KAKENHI-PROJECT-17K18123
[Presentation] 環状ジセレニド部位を酸化還元中心とするチオレドキシンファミリーミミックの開発2019
- Author(s)
  塚越俊介、荒井堅太
- Organizer
  第46回有機典型元素化学討論会
- Data Source
  KAKENHI-PROJECT-17K18123
[Presentation] Bio-redox regulation by small molecular diselenide and selenenyl sulfide compounds2018
- Author(s)
  Kenta Arai
- Organizer
  VII Encontro sobre Enxofre, Selenio e Telurio and 7th Workshop of the SeS Redox & Catalysis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18123
[Presentation] インスリンおよびセレノインスリンの化学合成と生物活性2018
- Author(s)
  荒井堅太
- Organizer
  第45回有機典型元素化学討論会
- Data Source
  KAKENHI-PROJECT-17K18123
[Presentation] 生体酸化還元反応を制御する含セレン酵素ミミックの開発2018
- Author(s)
  荒井堅太
- Organizer
  細胞でつながる研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K18123
[Presentation] ウシ膵臓インスリンおよびその[C7UA,C7UB]変異体の酸化的フォールディング経路、立体構造、および生理活性に関する研究2017
- Author(s)
  荒井堅太
- Organizer
  第１７回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17K18123
[Presentation] インスリンおよびセレノインスリンの全合成と生物活性2017
- Author(s)
  荒井堅太
- Organizer
  第5回　内分泌代謝懇話会
- Invited
- Data Source
  KAKENHI-PROJECT-17K18123
[Presentation] 含セレン有機化合物によるタンパク質の酸化的フォールディング反応の制御2017
- Author(s)
  荒井堅太
- Organizer
  蛋白研セミナー：カルコゲン, ヘテロ元素を含む生体分子の化学
- Invited
- Data Source
  KAKENHI-PROJECT-17K18123
[Presentation] CYCLIC SELENIUM COMPOUNDS: A NEW CLASS OF OXIDATIVE FOLDING REAGENT2017
- Author(s)
  Kenta Arai
- Organizer
  Symposium on Selenium Chemistry & Biology (SSCB-2017)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18123
[Presentation] Organoselenium compounds: A new class of oxidative folding reagent2017
- Author(s)
  Kenta Arai
- Organizer
  The 31st Annual Symposium of The Protein Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18123
[Presentation] 二本鎖フォールディング反応によるウシ膵臓インスリンおよびセレノインスリンの調製2017
- Author(s)
  荒井堅太
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-17K18123
[Presentation] Modeling of ER-resident oxidoreductases by using a small molecule with tetrahydroselenophene skeleton2016
- Author(s)
  Kenta Arai
- Organizer
  6th International Conference on Metals in Genetics, Chemical Biology and Therapeutics
- Place of Presentation
  Bangalore, India
- Year and Date
  2016-02-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26888016
[Presentation] SYNTHESIS OF WATER-SOLUBLE CYCLIC SELENIDES AND APPLICATION AS A GLUTATHIONE PEROXIDASE MIMIC.2015
- Author(s)
  Kenta Arai
- Organizer
  The 11thInternational Conference on Heteroatom Chemistry
- Place of Presentation
  Caen, France
- Year and Date
  2015-06-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26888016
[Presentation] Synthesis and application of cyclic selenides having high-polar functional　groups as ER-resident oxidoreductase models2015
- Author(s)
  Kenta Arai
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2015
- Place of Presentation
  Hawaii, USA
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26888016
[Presentation] 二種の小胞体内酸化還元酵素機能を併せもつ新しい両親媒性セレニド触媒の合成と応用2014
- Author(s)
  荒井堅太
- Organizer
  第41回有機典型元素化学討論会
- Place of Presentation
  宇部市文化会館ホール（宇部市）
- Year and Date
  2014-11-29
- Data Source
  KAKENHI-PROJECT-26888016

1. SATO Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 岩岡道夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
3. 日高雄二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 北條裕信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Arai Kenta 荒井 堅太

Research Projects

Research Products

Co-Researchers

Development of a method to control protein structure by redox-active molecules including chaperone-like activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development and pharmacological investigation of novel diselenide compounds as a medicine for folding diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of an effective folding procedure for SS-containing proteins by using a micro flow chemistryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Oxidative Protein Folding Using trans-3,4-Dihydroxyselenolane Oxide2019

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cyclic telluride reagents with remarkable glutathione peroxidase-like activity for purification-free synthesis of highly pure organodisulfides2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Modeling Thioredoxin Reductase‐Like Activity with Cyclic Selenenyl Sulfides: Participation of an NH???Se Hydrogen Bond through Stabilization of the Mixed Se?S Intermediate2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] インスリンの簡便な化学合成法の開発─未来の糖尿病治療への期待2018

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Rapid Electrochemical Conversion of Thiol and Disulfide into Difluoroand Trifluoromethyl Thioethers in a Microfluidic Reactor2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] インスリン製剤の簡便な化学合成への展開2018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Characterization and optimization of two-chain folding pathways of insulin via native chain assembly2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanism of radioprotection by dihydroxy-1-selenolane (DHS): Effect of fatty acid conjugation and role of glutathione peroxidase (GPx)2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Selenoglutathione Diselenide: Unique Redox Reactions in the GPx-Like Catalytic Cycle and Repairing of Disulfide Bonds in Scrambled Protein2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protein Folding in the Presence of Water-Soluble Cyclic Diselenides with Novel Oxidoreductase and Isomerase Activities2017

Author(s)

Journal Title

DOI

Arai Kenta 荒井堅太