Hosoya Tadashi 細矢匡

Researcher Number	60737104
Other IDs	https://orcid.org/0000-0001-5177-6413
Affiliation (Current)	2026: 東京科学大学, 大学院医歯学総合研究科, 准教授
Affiliation (based on the past Project Information) *help	2025: 東京科学大学, 大学院医歯学総合研究科, 准教授 2020 – 2024: 東京医科歯科大学, 大学院医歯学総合研究科, 講師 2019: 東京医科歯科大学, 大学院医歯学総合研究科, 助教 2016: 東京医科歯科大学, 大学院医歯学総合研究科, 助教 2015: 東京医科歯科大学, 医歯(薬)学総合研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Medical genome science Except Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related
Keywords	Principal Investigator 関節リウマチ / モデルマウス / 不育症 / 血栓塞栓症 / 抗リン脂質抗体 / 抗リン脂質抗体症候群 / 副腎皮質ステロイド / NFkB阻害 / NF-κB阻害薬 / 急性肝炎モデル … More / 関節炎モデル / NFκB / RNA-Seq / AP-1 / CDK4/6 / 滑膜線維芽細胞 / SNP機能解析 / 疾患感受性遺伝子 … More Except Principal Investigator 自然免疫 / 抗リン脂質抗体症候群 / 全身性エリテマトーデス Less

動物モデルを活用した抗リン脂質抗体依存的病態のメカニズムの解明Principal Investigator
- Principal Investigator
  
  細矢匡
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Institute of Science Tokyo
自然免疫および血管内皮障害に着目したSLE・APSの新規治療法の開発
- Principal Investigator
  
  保田晋助
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Tokyo Medical and Dental University
The novel anti-inflammatory drug development complementing with glucocorticoidPrincipal Investigator
- Principal Investigator
  
  Hosoya Tadashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Tokyo Medical and Dental University
Targeting synovial fibroblasts for the treatment of rheumatoid arthritis by CDK4/6 inhibitionPrincipal Investigator
- Principal Investigator
  
  Hosoya Tadashi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Tokyo Medical and Dental University
Pathological contribution of RA risk loci to the disease progression and the therapeutic responsePrincipal Investigator
- Principal Investigator
  
  Hosoya Tadashi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical genome science
- Research Institution
  Tokyo Medical and Dental University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Book

[Book] 成人におけるA20ハプロ不全症2023
- Author(s)
  庭野智子, 細矢匡
- Total Pages
  4
- Publisher
  リウマチ科
- Data Source
  KAKENHI-PROJECT-21K08472
[Book] 炎症性疾患の発症・再燃を予防する新規薬剤の開発2023
- Author(s)
  細矢匡, 馬場洋行, 近藤祐真, 保田晋助
- Total Pages
  12
- Publisher
  臨床薬理の進歩
- Data Source
  KAKENHI-PROJECT-21K08472
[Book] 「炎症性疾患の発症・再燃を予防する新規薬剤の開発」 Novel drug identification and development for aiming inflammatory disease onset and relapse, 「臨床薬理の進歩」No.442023
- Author(s)
  細矢匡、馬場洋行、近藤祐真、保田晋助
- Total Pages
  12
- Publisher
  臨床薬理研究振興財団
- Data Source
  KAKENHI-PROJECT-21K08472
[Book] 抗リン脂質抗体症候群(Antiphospholipid syndrome) 特集全身性エリテマトーデス(SLE)と臓器障害2023
- Author(s)
  川田大介, 細矢匡, 保田晋助
- Total Pages
  7
- Publisher
  臨床免疫・アレルギー科
- Data Source
  KAKENHI-PROJECT-21K08472
[Book] 関節リウマチの臨床と検査2020
- Author(s)
  細矢匡
- Total Pages
  5
- Publisher
  東京都医学検査
- Data Source
  KAKENHI-PROJECT-19K17884
[Journal Article] Diverse pro-inflammatory ability of mutated spike protein derived from variant strains of SARS-CoV-22024
- Author(s)
  Kawata Daisuke、Iwai Hideyuki、Oba Seiya、Komiya Yoji、Koike Ryuji、Miyamoto Sho、Kanno Takayuki、Ainai Akira、Suzuki Tadaki、Hosoya Tadashi、Yasuda Shinsuke
- Journal Title
  
  Cytokine
  
  Volume: 178 Pages: 156592-156592
- DOI
  10.1016/j.cyto.2024.156592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08472
[Journal Article] Anti-inflammatory effects of a novel NF-kB inhibitory derivative derived from pyrazolo[3,4- d ]pyrimidine in three inflammation models2024
- Author(s)
  Baba Hiroyuki、Hosoya Tadashi、Ishida Ryosuke、Tai Kenpei、Hatsuzawa Saki、Kondo Yuma、Kusuhara Hiroyuki、Kagechika Hiroyuki、Yasuda Shinsuke
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: 388 Issue: 3 Pages: 788-797
- DOI
  10.1124/jpet.123.001904
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08472
[Journal Article] Apple-shaped obesity: A risky soil for cytokine-accelerated severity in COVID-192023
- Author(s)
  Hosoya Tadashi、et al.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 22
- DOI
  10.1073/pnas.2300155120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08472, KAKENHI-PROJECT-21K18260, KAKENHI-ORGANIZER-22H05060, KAKENHI-PLANNED-22H05061, KAKENHI-PROJECT-23K24385
[Journal Article] Thrombosis and antiphospholipid antibodies in Japanese COVID-19: based on propensity score matching2023
- Author(s)
  Oba Seiya、Hosoya Tadashi、Kaneshige Risa、Kawata Daisuke、Yamaguchi Taiki、Mitsumura Takahiro、Shimada Sho、Shibata Sho、Tateishi Tomoya、Koike Ryuji、Tohda Shuji、Hirakawa Akihiro、Yoko Nukui、Otomo Yasuhiro、Nojima Junzo、Miyazaki Yasunari、Yasuda Shinsuke
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1227547-1227547
- DOI
  10.3389/fimmu.2023.1227547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08472
[Journal Article] Chondroprotective effects of CDK4/6 inhibition via enhanced ubiquitin-dependent degradation of JUN in synovial fibroblasts.2021
- Author(s)
  Hosoya T, Saito T, Baba H, Tanaka N, Noda S, Komiya Y, Tagawa Y, Yamamoto A, Mizoguchi F, Kawahata K, Miyasaka N, Kohsaka H, Yasuda S
- Journal Title
  
  Rheumatology (Oxford).
  
  Volume: 61 Issue: 8 Pages: 3427-3438
- DOI
  10.1093/rheumatology/keab874
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17884, KAKENHI-PROJECT-20K08785
[Journal Article] Editorial: Targeting the Chemoattractant System in Inflammation2021
- Author(s)
  Hosoya Tadashi、Cordelia Dunai、Michael Benedict D.、Miyabe Chie、Nagai Jun、Murooka Thomas T.、Miyabe Yoshishige
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 12 Pages: 744290-744290
- DOI
  10.3389/fphar.2021.744290
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08895, KAKENHI-PROJECT-19K17813, KAKENHI-PROJECT-19K17884
[Journal Article] Therapeutic effect of cyclin-dependent kinase 4/6 inhibitor in monotherapy or in combination with transforming growth factor-beta receptor inhibitor on dermal fibrosis in murine models of systemic sclerosis2021
- Author(s)
  Akio Yamamoto, Tetsuya Saito, Tadashi Hosoya, Shinsuke Yasuda, Kimito Kawahata, Fumitaka Mizoguchi, Hitoshi Kohsaka
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17884
[Journal Article] Novel treatment strategy of polymyalgia rheumatica targeting drug-free remission2020
- Author(s)
  Tadashi Hosoya, Takahiko Sugihara, Nobuyuki Miyasaka, Shinsuke Yasuda
- Journal Title
  
  Clinical and Experimental Rheumatology
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17884
[Journal Article] Identification of Compounds With Glucocorticoid Sparing Effects on Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-Like Synoviocytes2020
- Author(s)
  Tadashi Hosoya, Nikunj M Shukla, Yuya Fujita, Shiyin Yao, Fitzgerald S Lao, Hiroyuki Baba, Shinsuke Yasuda, Howard B Cottam, Dennis A Carson, Tomoko Hayashi, Maripat Corr
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: -
- DOI
  10.3389/fphar.2020.607713
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17884
[Presentation] Inhibition of FAS-mediated alveolar epithelial cell death suppresses lung injury and subsequent inflammasome activation in murine COVID-19 model.2023
- Author(s)
  Yoji Komiya, Tadashi Hosoya, Seiya Oba, Daisuke Kawata, Mari Kamiya, Hideyuki Iwai, Sho Miyamoto, Takayuki Kanno, Tobiume Minoru, Akira Ainai, Tadaki Suzuki, Hideki Hasegawa, Shinsuke Yasuda.
- Organizer
  The 2nd International Symposium of Clinical Immunology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08472
[Presentation] High-throughput screeningで見出した新規NF-κB抑制性化合物の動物モデルにおける抗炎症作用の検討2023
- Author(s)
  馬場洋行, 細矢匡, 近藤佑真, 初澤早貴，石田良典, 影近弘之, 保田晋助,
- Organizer
  第44回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-21K08472
[Presentation] The Underlying Mechanisms of Obesity-Related COVID-19 Exacerbations2023
- Author(s)
  Seiya Oba, Tadashi Hosoya, Yoji Komiya, Daisuke Kawata, Mari Kamiya, Hideyuki Iwai, Sho Miyamoto, Takayuki Kanno, Tobiume Minoru, Akira Ainai, Tadaki Suzuki, Hideki Hasegawa, Shinsuke Yasuda.
- Organizer
  米国臨床免疫学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08472
[Presentation] High-throughput screeningで見出した新規NF-κB抑制性化合物の動物モデルにおける抗炎症作用の検討2023
- Author(s)
  馬場洋行, 細矢匡, 近藤佑真, 初澤早貴，石田良典, 影近弘之, 保田晋助
- Organizer
  第67回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K08472
[Presentation] COVID-19関連血栓症と抗リン脂質抗体の関連2023
- Author(s)
  大庭聖也, 細矢匡, 川田大介, 庭野智子, 小宮陽仁, 佐々木広和, 神谷麻理, 山本晃央, 岩井秀之, 保田晋助
- Organizer
  日本リウマチ学会総会
- Data Source
  KAKENHI-PROJECT-21K08472
[Presentation] リウマチ性疾患におけるCOVID19感染症の基礎研究 COVID-19の肺障害はFAS依存性の肺胞上皮細胞の細胞死により重症化する2023
- Author(s)
  小宮陽仁, 神谷麻理, 川田大介, 大庭聖也, 岩井秀之, 細矢匡, 保田晋助
- Organizer
  日本リウマチ学会総会
- Data Source
  KAKENHI-PROJECT-21K08472
[Presentation] Obesity-related exacerbations of COVID-19 via accelerated cytokine responses.2023
- Author(s)
  Seiya Oba, Tadashi Hosoya, Yoji Komiya, Daisuke Kawata, Mari Kamiya, Hideyuki Iwai, Sho Miyamoto, Takayuki Kanno, Tobiume Minoru, Akira Ainai, Tadaki Suzuki, Hideki Hasegawa, Shinsuke Yasuda.
- Organizer
  The 2nd International Symposium of Clinical Immunology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08472
[Presentation] リウマチ性疾患におけるCOVID19感染症の基礎研究 SARS-CoV-2 S蛋白は由来株によるCOVID-19重症度を反映してマクロファージを直接活性化する2023
- Author(s)
  川田大介, 岩井秀之, 大庭聖也, 小宮陽仁, 細矢匡, 保田晋助
- Organizer
  日本リウマチ学会総会
- Data Source
  KAKENHI-PROJECT-21K08472
[Presentation] 新規NF-κB抑制性化合物は生体内でも炎症発症抑制効果を示す、2022
- Author(s)
  馬場洋行, 細矢匡, 近藤佑真,石田良典, 影近弘之, 保田晋助
- Organizer
  第43回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08472
[Presentation] Anti-inflammatory effects of novel NF-κB inhibitory compounds in two inflammatory animal models,2022
- Author(s)
  Hiroyuki Baba, Tadashi Hosoya, Yuma Kondo, Ryosuke Ishida, Hiroyuki Kagechika, Shinsuke Yasuda
- Organizer
  第51回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08472
[Presentation] Anti-inflammatory effects of novel NF-κB inhibitory compounds in two inflammatory animal models2022
- Author(s)
  Hiroyuki Baba, Tadashi Hosoya, Yuma Kondo, Saki Hatsuzawa, Ryosuke Ishida, Hiroyuki Kagechika, Shinsuke Yasuda
- Organizer
  第７回生体医歯工学共同研究拠点
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08472
[Presentation] Cyclin Dependent Kinase 4 and 6 Determine the Cytokine Responsiveness by Stabilizing JUN in Rheumatoid Arthritis Synovial Fibroblasts.2021
- Author(s)
  Tadashi Hosoya, Yasuhiro Tagawa, Hiroyuki Baba, Seiji Noda, Shinsuke Yasuda
- Organizer
  ACR Convergence
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17884
[Presentation] The active cyclin dependent kinase 4 and 6 contributed in the MMP-1/3 productions by stabilizing JUN in rheumatoid arthritis synovial fibroblasts.2021
- Author(s)
  Tadashi Hosoya, Yasuhiro Tagawa, Hiroyuki Baba, Seiji Noda, Shinsuke Yasuda
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K17884
[Presentation] Novel compound that impacts migration and chemokine production via NFkB suppressing activity2021
- Author(s)
  Tadashi Hosoya, Hiroyuki Baba, Shinsuke Yasuda, Maripat Corr
- Organizer
  日本リウマチ学会総会
- Data Source
  KAKENHI-PROJECT-19K17884
[Presentation] 細胞周期制御分子CDK4/6は転写因子JUNの安定性制御を介してリウマチ滑膜線維芽細胞のサイトカイン産生能を調節する2021
- Author(s)
  細矢匡、斎藤鉄也、馬場洋行、田中奈緒、野田聖二、小宮陽仁、田川泰寛、山本晃央、保田晋助
- Organizer
  日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-19K17884
[Presentation] Novel compound that impacts FLS migration and chemokine production via NFkB suppressing activity2020
- Author(s)
  Tadashi Hosoya, Hiroyuki Baba, Shinsuke Yasuda, Maripat Corr
- Organizer
  第65回日本リウマチ学会総会・学術集会 International Concurrent Workshop
- Data Source
  KAKENHI-PROJECT-19K17884
[Presentation] Identification of Small Molecules with Efficacy as Steroid Sparing Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-like Synoviocytes2020
- Author(s)
  Tadashi Hosoya, Nikunj Shukla, Yuya Fujita, Shiyin Yao, Fitzgerald Lao, Hiroyuki Baba, Shinsuke Yasuda, Howard Cottam, Dennis Carson, Tomoko Hayashi and Mary Corr
- Organizer
  ACR Convergence 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17884
[Presentation] CDK4/6阻害薬が有するリウマチ滑膜線維芽細胞に対する抗リウマチ作用の解析2019
- Author(s)
  細矢匡、斎藤鉄也、田川泰寛、山本晃央、溝口史高、川畑仁人、宮坂信之、上阪等
- Organizer
  骨免疫ワークショップ
- Data Source
  KAKENHI-PROJECT-19K17884

1. 保田晋助 (00374231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 宮部斉重

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hosoya Tadashi 細矢 匡

Research Projects

Research Products

Co-Researchers

動物モデルを活用した抗リン脂質抗体依存的病態のメカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

自然免疫および血管内皮障害に着目したSLE・APSの新規治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The novel anti-inflammatory drug development complementing with glucocorticoidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Targeting synovial fibroblasts for the treatment of rheumatoid arthritis by CDK4/6 inhibitionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathological contribution of RA risk loci to the disease progression and the therapeutic responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 成人におけるA20ハプロ不全症2023

Author(s)

Total Pages

Publisher

Data Source

[Book] 炎症性疾患の発症・再燃を予防する新規薬剤の開発2023

Author(s)

Total Pages

Publisher

Data Source

[Book] 「炎症性疾患の発症・再燃を予防する新規薬剤の開発」 Novel drug identification and development for aiming inflammatory disease onset and relapse, 「臨床薬理の進歩」No.442023

Author(s)

Total Pages

Publisher

Data Source

[Book] 抗リン脂質抗体症候群(Antiphospholipid syndrome) 特集 全身性エリテマトーデス(SLE)と臓器障害2023

Author(s)

Total Pages

Publisher

Data Source

[Book] 関節リウマチの臨床と検査2020

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Diverse pro-inflammatory ability of mutated spike protein derived from variant strains of SARS-CoV-22024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-inflammatory effects of a novel NF-kB inhibitory derivative derived from pyrazolo[3,4- d ]pyrimidine in three inflammation models2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Apple-shaped obesity: A risky soil for cytokine-accelerated severity in COVID-192023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Thrombosis and antiphospholipid antibodies in Japanese COVID-19: based on propensity score matching2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chondroprotective effects of CDK4/6 inhibition via enhanced ubiquitin-dependent degradation of JUN in synovial fibroblasts.2021

Hosoya Tadashi 細矢匡

[Book] 抗リン脂質抗体症候群(Antiphospholipid syndrome) 特集全身性エリテマトーデス(SLE)と臓器障害2023