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Kimura Taeko  木村 妙子

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KIMURA TAEKO  木村 妙子

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Researcher Number 60748820
Other IDs
Affiliation (Current) 2025: 東京大学, 大学院薬学系研究科(薬学部), 助教
2025: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 研究員
Affiliation (based on the past Project Information) *help 2023 – 2024: 東京大学, 大学院薬学系研究科(薬学部), 特任助教
2020: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 研究員
2019: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員
2017 – 2018: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 脳機能イメージング研究部, 学振特別研究員
2016: 首都大学東京, 理工学研究科, 特任研究員
2015: 首都大学東京, 理工学研究科, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Neurochemistry/Neuropharmacology / Nerve anatomy/Neuropathology
Except Principal Investigator
Medium-sized Section 47:Pharmaceutical sciences and related fields
Keywords
Principal Investigator
Tau / アルツハイマー病 / タウアイソフォーム / タウオパチー / リン酸化 / タウ / Aβ / tauopathy / tau / Tauopathy … More / CTE / TBI / イメージング / リン酸化解析 / Thr231 / 核局在 / Cdk / phosphorylation / ピック病 / 皮質基底核変性症 / 嗜銀顆粒性認知症 / Phos-Tag / マーモセット / Phos-Tag SDS-PAGE / 患者脳 / ADモデルマウス / R406W / ヒト患者脳 / Cdk5 / Phos-Tag SDS-PAGE法 … More
Except Principal Investigator
細胞連関 / グリア細胞 / 神経変性 / 機能連関 / ストレス応答 / 認知症 Less
  • Research Projects

    (4 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (5 People)
  •  中枢神経系プロテイノパチー発症機構の統合的解明

    • Principal Investigator
      富田 泰輔
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      The University of Tokyo
  •  外傷性脳損傷モデルを用いたタウオパチー病理メカニズム解明への新規アプローチPrincipal Investigator

    • Principal Investigator
      木村 妙子
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      The University of Tokyo
  •  Tauopathy Analysis of tau phosphorylation specific to neurodegenerative diseases and elucidation of pathogenic factorsPrincipal Investigator

    • Principal Investigator
      KIMURA Taeko
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
      National Institutes for Quantum and Radiological Science and Technology
  •  Novel quantitative analysis of abnormal phosphorylated tauPrincipal Investigator

    • Principal Investigator
      KIMURA TAEKO
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Tokyo Metropolitan University

All 2024 2023 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation Book Other

  • [Book] タウオパチー神経変性疾患と脳内炎症2020

    • Author(s)
      木村妙子, 久永眞市, 長谷川成人
    • Total Pages
      5
    • Publisher
      別冊BIO Clinica
    • Data Source
      KAKENHI-PROJECT-17K07113
  • [Journal Article] Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers2024

    • Author(s)
      Taeko Kimura, Haruaki Sato, Maria Kano, Lisa Tatsumi, Taisuke Tomita
    • Journal Title

      FEBS Open Bio

      Volume: 14 Pages: 181-193

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K06112
  • [Journal Article] Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers2023

    • Author(s)
      Kimura Taeko、Sato Haruaki、Kano Maria、Tatsumi Lisa、Tomita Taisuke
    • Journal Title

      FEBS Open Bio

      Volume: 14 Issue: 2 Pages: 181-193

    • DOI

      10.1002/2211-5463.13667

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23H00394
  • [Journal Article] Tau isoform expression and phosphorylateion in marmotset brains.2019

    • Author(s)
      Sharma G, Huo A, Kimura T, Shiozawa S, Kobayashi R, Sahara N, Ishibashi M, Ishigaki S, Saito T, Ando K, Murayama S, Hasegawa M, Sobue G, Okano H, Hisanaga SI.
    • Journal Title

      J Biol Chem.

      Volume: 26;294(30) Pages: 11433-11444

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07113
  • [Journal Article] Pathological progression induced by the frontotemporal dementia-associated R406W tau mutation in patient-derived iPSCs.2019

    • Author(s)
      Nakamura M, Shiozawa S, Tsuboi D, Amano M, Watanabe H, Maeda S, Kimura T, Yoshimatsu S, Kisa F, Karch CM, Miyasaka T, Takashima A, Sahara N, Hisanaga S, Ikeuchi T, Kaibuchi K, Okano H
    • Journal Title

      Stem Cell Reports.

      Volume: 8;13(4) Pages: 684-699

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07113
  • [Journal Article] Tau Fibril Formation in Cultured Cells Compatible with a Mouse Model of Tauopathy2018

    • Author(s)
      Matsumoto Gen、Matsumoto Kazuki、Kimura Taeko、Suhara Tetsuya、Higuchi Makoto、Sahara Naruhiko、Mori Nozomu
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 5 Pages: 1497-1497

    • DOI

      10.3390/ijms19051497

    • NAID

      120006988072

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07098, KAKENHI-PROJECT-17K07111, KAKENHI-PROJECT-17K07113, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-17J06398
  • [Journal Article] Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.2018

    • Author(s)
      Tuerde, D., Kimura, T., Miyasaka, T., Furusawa, K., Shimozawa, A., Hasegawa, M., Ando, A., Hisanaga, S.
    • Journal Title

      J. Biol, Chem.

      Volume: 293 Issue: 5 Pages: 1781-1793

    • DOI

      10.1074/jbc.m117.798918

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07060, KAKENHI-PROJECT-17K07113, KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-17J06398
  • [Journal Article] Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy2018

    • Author(s)
      Kimura T, Sharma G, Ishiguro K, Hisanaga SI
    • Journal Title

      Front Neurosci

      Volume: 12 Pages: 44-44

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07113
  • [Journal Article] Biochemical Properties of Pathology-Related Tau Species in Tauopathy Brains: An Extraction Protocol for Tau Oligomers and Aggregates2018

    • Author(s)
      Sahara Naruhiko、Kimura Taeko
    • Journal Title

      Methods Mol Biol

      Volume: 1007 Pages: 435-445

    • DOI

      10.1007/978-1-4939-7816-8_26

    • ISBN
      9781493978151, 9781493978168
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07113, KAKENHI-PROJECT-17J06398
  • [Journal Article] Phos-tag SDS-PAGE analysis of complicated phosphorylation of a neurodegenerative disease protein tau2017

    • Author(s)
      木村 妙子、久永 眞市
    • Journal Title

      Electrophoresis Letters

      Volume: 61 Issue: 2 Pages: 49-52

    • DOI

      10.2198/electroph.61.49

    • NAID

      130006207357

    • ISSN
      2189-2628, 2189-2636
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07113, KAKENHI-PROJECT-17J06398
  • [Journal Article] In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains.2017

    • Author(s)
      Krishnankutty, A., Kimura, T., Saito, T., Aoyagi, K., Asada, A., Takahashi, S., Ando, K., Ohara-Imaizumi, M., Ishiguro, K., Hisanaga, S.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 8602-8602

    • DOI

      10.1038/s41598-017-09239-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07060, KAKENHI-PROJECT-17K07113, KAKENHI-PROJECT-17K08547, KAKENHI-PROJECT-17K09845, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-17J06398, KAKENHI-PROJECT-26460396
  • [Journal Article] The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method.2016

    • Author(s)
      Kimura T, Hatsuta H, Masuda-Suzukake M, Hosokawa M, Ishiguro K, Akiyama H, Murayama S, Hasegawa M, Hisanaga S.
    • Journal Title

      Am J Pathol

      Volume: 186 Pages: 398-409

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18366
  • [Journal Article] Quantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants.2016

    • Author(s)
      Kimura T, Hosokawa T, Taoka M, Tsutsumi K, Ando K, Ishiguro K, Hosokawa M, Hasegawa M, Hisanaga S.
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 33479-33479

    • DOI

      10.1038/srep33479

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-15K18366, KAKENHI-PROJECT-16K07060
  • [Presentation] Tauopathy research using a novel traumatic brain injury model.2024

    • Author(s)
      Taeko Kimura, Masami Masuda-Suzukake, Masashi Hahimoto, Shin-Ichi Hisanaga, Taisuke Tomita, Masato Hasegawa
    • Organizer
      AD/PD2024
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23H00394
  • [Presentation] TAUOPATHY RESEARCH USING A NOVEL TRAUMATIC BRAIN INJURY MODEL2024

    • Author(s)
      Taeko Kimura
    • Organizer
      AD/PD 2024
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K06112
  • [Presentation] AAV-PHP.eB 発現系を用いたタウオパチーモデルマウスの作製2023

    • Author(s)
      巽理紗、高鳥翔、木村妙子、富田泰輔
    • Organizer
      2023年度日本生化学会関東支部例会
    • Data Source
      KAKENHI-PROJECT-23H00394
  • [Presentation] 外傷性脳損傷の新規モデルを用いたタウオパチー病理研究2023

    • Author(s)
      木村妙子、鈴掛雅美、橋本雅史、久永眞一、富田泰輔、長谷川成人
    • Organizer
      第42回日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-23H00394
  • [Presentation] PHFタウ線維in vivo再構成モデルの確立2023

    • Author(s)
      鹿野真吏亜、木村妙子、富田泰輔
    • Organizer
      タウ研究会
    • Data Source
      KAKENHI-PROJECT-23H00394
  • [Presentation] 迅速かつ簡便にtau凝集を誘導できるタウオパチーモデルマウスの樹立2023

    • Author(s)
      巽理紗、高鳥翔、木村妙子、富田泰輔
    • Organizer
      第96回日本生化学大会
    • Data Source
      KAKENHI-PROJECT-23H00394
  • [Presentation] 新規TBIモデルCHIMERAについて2023

    • Author(s)
      木村妙子
    • Organizer
      第42回日本認知症学会 (シンポジウム)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K06112
  • [Presentation] 外傷性脳損傷の新規モデルCHIMERAを用いたタウオパチー病理研究2023

    • Author(s)
      木村妙子
    • Organizer
      第42回日本認知症学会 (ポスター)
    • Data Source
      KAKENHI-PROJECT-23K06112
  • [Presentation] [18F]PM-PBB3 PET imaging of Tau deposition in the tauopathy model mice. poster presentation.2019

    • Author(s)
      Taeko Kimura, Chie Seki, Kazuaki Sampei, Jun Maeda, Maiko Ono, Tetsuya Suhara, Ming-Rong Zhang, Naruhiko Sahara and Makoto Higuchi
    • Organizer
      The 29th international symposium on cerebral blood flow, metabolism and function. The 14th international conference on quantification of Brain function with PET.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07113
  • [Presentation] Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy.2018

    • Author(s)
      木村妙子
    • Organizer
      第40回日本生物学的精神医学会 第61回日本神経化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K07113
  • [Presentation] タウモデルマウスを用いた新規タウPETリガンド[18F]PM-PBB3の有用性2018

    • Author(s)
      木村妙子
    • Organizer
      新学術領域研究 脳タンパク質老化と認知症制御 第8回班員会議・第4回リトリート
    • Data Source
      KAKENHI-PROJECT-17K07113
  • [Presentation] タウモデルマウスを用いた新規タウPETリガンド[18F]PM-PBB3の有用性2018

    • Author(s)
      木村妙子
    • Organizer
      第37回日本認知症学会学
    • Data Source
      KAKENHI-PROJECT-17K07113
  • [Presentation] Development of in vivo imaging platform for investigating pathological tau propagation2017

    • Author(s)
      木村妙子
    • Organizer
      新学術領域研究「脳タンパク質老化と認知症制御」第2回国際シンポジウム
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07113
  • [Presentation] 複雑怪奇なリン酸化タンパク質タウのPhos-Tag解析2017

    • Author(s)
      木村妙子,久永眞市
    • Organizer
      第68回日本電気泳動学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K07113
  • [Presentation] Tauは細胞内で多様なリン酸化状態として存在する2016

    • Author(s)
      木村妙子、石黒幸一、 長谷川成人、 久永眞市
    • Organizer
      第59回 日本神経化学会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-08
    • Data Source
      KAKENHI-PROJECT-15K18366
  • [Presentation] Tauは細胞内で多様なリン酸化状態として存在する2016

    • Author(s)
      木村妙子、久永眞市
    • Organizer
      第4回新学術班会議
    • Place of Presentation
      千葉
    • Year and Date
      2016-06-03
    • Data Source
      KAKENHI-PROJECT-15K18366
  • [Presentation] New insights in quantitative analysis of phosphorylation of Tau in AD model mouse and Tauopathy brains by Phos-tag SDS-PAGE.2015

    • Author(s)
      Taeko Kimura
    • Organizer
      25th meeting of the International society for neurochemistry
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2015-08-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18366
  • [Presentation] Phos-tag SDS-PAGE法による神経変性疾患タウのリン酸化解析2015

    • Author(s)
      木村妙子
    • Organizer
      第66回電気泳動学会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K18366
  • [Presentation] The abundance of nonphosphorylated tau among heterogeneously phosphorylated tau species in vivo in mouse and human tauopathy brains2015

    • Author(s)
      Taeko Kimura
    • Organizer
      第58回日本神経化学会大会
    • Place of Presentation
      埼玉
    • Year and Date
      2015-09-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K18366
  • []

  • 1.  久永 眞市 (20181092)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 2.  富田 泰輔 (30292957)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 3.  堀 由起子 (80610683)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  高鳥 翔 (80624361)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  MATSUMOTO Gen
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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