Kimura Taeko 木村妙子

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KIMURA TAEKO 木村妙子

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Researcher Number	60748820
Other IDs
Affiliation (Current)	2025: 東京大学, 大学院薬学系研究科(薬学部), 助教 2025: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 研究員
Affiliation (based on the past Project Information) *help	2023 – 2024: 東京大学, 大学院薬学系研究科(薬学部), 特任助教 2020: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 研究員 2019: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員 2017 – 2018: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所脳機能イメージング研究部, 学振特別研究員 2016: 首都大学東京, 理工学研究科, 特任研究員 2015: 首都大学東京, 理工学研究科, 研究員
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Neurochemistry/Neuropharmacology / Nerve anatomy/Neuropathology Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields
Keywords	Principal Investigator Tau / アルツハイマー病 / タウアイソフォーム / タウオパチー / リン酸化 / タウ / Aβ / tauopathy / tau / Tauopathy … More / CTE / TBI / イメージング / リン酸化解析 / Thr231 / 核局在 / Cdk / phosphorylation / ピック病 / 皮質基底核変性症 / 嗜銀顆粒性認知症 / Phos-Tag / マーモセット / Phos-Tag SDS-PAGE / 患者脳 / ADモデルマウス / R406W / ヒト患者脳 / Cdk5 / Phos-Tag SDS-PAGE法 … More Except Principal Investigator 細胞連関 / グリア細胞 / 神経変性 / 機能連関 / ストレス応答 / 認知症 Less

中枢神経系プロテイノパチー発症機構の統合的解明
- Principal Investigator
  
  富田泰輔
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
外傷性脳損傷モデルを用いたタウオパチー病理メカニズム解明への新規アプローチPrincipal Investigator
- Principal Investigator
  
  木村妙子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  The University of Tokyo
Tauopathy Analysis of tau phosphorylation specific to neurodegenerative diseases and elucidation of pathogenic factorsPrincipal Investigator
- Principal Investigator
  
  KIMURA Taeko
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
  National Institutes for Quantum and Radiological Science and Technology
Novel quantitative analysis of abnormal phosphorylated tauPrincipal Investigator
- Principal Investigator
  
  KIMURA TAEKO
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan University

All 2024 2023 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation Book Other

[Book] タウオパチー神経変性疾患と脳内炎症2020
- Author(s)
  木村妙子, 久永眞市, 長谷川成人
- Total Pages
  5
- Publisher
  別冊BIO Clinica
- Data Source
  KAKENHI-PROJECT-17K07113
[Journal Article] Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers2024
- Author(s)
  Taeko Kimura, Haruaki Sato, Maria Kano, Lisa Tatsumi, Taisuke Tomita
- Journal Title
  
  FEBS Open Bio
  
  Volume: 14 Pages: 181-193
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06112
[Journal Article] Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers2023
- Author(s)
  Kimura Taeko、Sato Haruaki、Kano Maria、Tatsumi Lisa、Tomita Taisuke
- Journal Title
  
  FEBS Open Bio
  
  Volume: 14 Issue: 2 Pages: 181-193
- DOI
  10.1002/2211-5463.13667
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H00394
[Journal Article] Tau isoform expression and phosphorylateion in marmotset brains.2019
- Author(s)
  Sharma G, Huo A, Kimura T, Shiozawa S, Kobayashi R, Sahara N, Ishibashi M, Ishigaki S, Saito T, Ando K, Murayama S, Hasegawa M, Sobue G, Okano H, Hisanaga SI.
- Journal Title
  
  J Biol Chem.
  
  Volume: 26;294(30) Pages: 11433-11444
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07113
[Journal Article] Pathological progression induced by the frontotemporal dementia-associated R406W tau mutation in patient-derived iPSCs.2019
- Author(s)
  Nakamura M, Shiozawa S, Tsuboi D, Amano M, Watanabe H, Maeda S, Kimura T, Yoshimatsu S, Kisa F, Karch CM, Miyasaka T, Takashima A, Sahara N, Hisanaga S, Ikeuchi T, Kaibuchi K, Okano H
- Journal Title
  
  Stem Cell Reports.
  
  Volume: 8;13(4) Pages: 684-699
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07113
[Journal Article] Tau Fibril Formation in Cultured Cells Compatible with a Mouse Model of Tauopathy2018
- Author(s)
  Matsumoto Gen、Matsumoto Kazuki、Kimura Taeko、Suhara Tetsuya、Higuchi Makoto、Sahara Naruhiko、Mori Nozomu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 5 Pages: 1497-1497
- DOI
  10.3390/ijms19051497
- NAID
  120006988072
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07098, KAKENHI-PROJECT-17K07111, KAKENHI-PROJECT-17K07113, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-17J06398
[Journal Article] Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.2018
- Author(s)
  Tuerde, D., Kimura, T., Miyasaka, T., Furusawa, K., Shimozawa, A., Hasegawa, M., Ando, A., Hisanaga, S.
- Journal Title
  
  J. Biol, Chem.
  
  Volume: 293 Issue: 5 Pages: 1781-1793
- DOI
  10.1074/jbc.m117.798918
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07060, KAKENHI-PROJECT-17K07113, KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-17J06398
[Journal Article] Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy2018
- Author(s)
  Kimura T, Sharma G, Ishiguro K, Hisanaga SI
- Journal Title
  
  Front Neurosci
  
  Volume: 12 Pages: 44-44
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07113
[Journal Article] Biochemical Properties of Pathology-Related Tau Species in Tauopathy Brains: An Extraction Protocol for Tau Oligomers and Aggregates2018
- Author(s)
  Sahara Naruhiko、Kimura Taeko
- Journal Title
  
  Methods Mol Biol
  
  Volume: 1007 Pages: 435-445
- DOI
  10.1007/978-1-4939-7816-8_26
- ISBN
  9781493978151, 9781493978168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07113, KAKENHI-PROJECT-17J06398
[Journal Article] Phos-tag SDS-PAGE analysis of complicated phosphorylation of a neurodegenerative disease protein tau2017
- Author(s)
  木村妙子、久永眞市
- Journal Title
  
  Electrophoresis Letters
  
  Volume: 61 Issue: 2 Pages: 49-52
- DOI
  10.2198/electroph.61.49
- NAID
  130006207357
- ISSN
  2189-2628, 2189-2636
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07113, KAKENHI-PROJECT-17J06398
[Journal Article] In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains.2017
- Author(s)
  Krishnankutty, A., Kimura, T., Saito, T., Aoyagi, K., Asada, A., Takahashi, S., Ando, K., Ohara-Imaizumi, M., Ishiguro, K., Hisanaga, S.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 8602-8602
- DOI
  10.1038/s41598-017-09239-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07060, KAKENHI-PROJECT-17K07113, KAKENHI-PROJECT-17K08547, KAKENHI-PROJECT-17K09845, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-17J06398, KAKENHI-PROJECT-26460396
[Journal Article] The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method.2016
- Author(s)
  Kimura T, Hatsuta H, Masuda-Suzukake M, Hosokawa M, Ishiguro K, Akiyama H, Murayama S, Hasegawa M, Hisanaga S.
- Journal Title
  
  Am J Pathol
  
  Volume: 186 Pages: 398-409
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18366
[Journal Article] Quantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants.2016
- Author(s)
  Kimura T, Hosokawa T, Taoka M, Tsutsumi K, Ando K, Ishiguro K, Hosokawa M, Hasegawa M, Hisanaga S.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 33479-33479
- DOI
  10.1038/srep33479
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-15K18366, KAKENHI-PROJECT-16K07060
[Presentation] Tauopathy research using a novel traumatic brain injury model.2024
- Author(s)
  Taeko Kimura, Masami Masuda-Suzukake, Masashi Hahimoto, Shin-Ichi Hisanaga, Taisuke Tomita, Masato Hasegawa
- Organizer
  AD/PD2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] TAUOPATHY RESEARCH USING A NOVEL TRAUMATIC BRAIN INJURY MODEL2024
- Author(s)
  Taeko Kimura
- Organizer
  AD/PD 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06112
[Presentation] AAV-PHP.eB 発現系を用いたタウオパチーモデルマウスの作製2023
- Author(s)
  巽理紗、高鳥翔、木村妙子、富田泰輔
- Organizer
  2023年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] 外傷性脳損傷の新規モデルを用いたタウオパチー病理研究2023
- Author(s)
  木村妙子、鈴掛雅美、橋本雅史、久永眞一、富田泰輔、長谷川成人
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] PHFタウ線維in vivo再構成モデルの確立2023
- Author(s)
  鹿野真吏亜、木村妙子、富田泰輔
- Organizer
  タウ研究会
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] 迅速かつ簡便にtau凝集を誘導できるタウオパチーモデルマウスの樹立2023
- Author(s)
  巽理紗、高鳥翔、木村妙子、富田泰輔
- Organizer
  第96回日本生化学大会
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] 新規TBIモデルCHIMERAについて2023
- Author(s)
  木村妙子
- Organizer
  第42回日本認知症学会　（シンポジウム）
- Invited
- Data Source
  KAKENHI-PROJECT-23K06112
[Presentation] 外傷性脳損傷の新規モデルCHIMERAを用いたタウオパチー病理研究2023
- Author(s)
  木村妙子
- Organizer
  第42回日本認知症学会　(ポスター)
- Data Source
  KAKENHI-PROJECT-23K06112
[Presentation] [18F]PM-PBB3 PET imaging of Tau deposition in the tauopathy model mice. poster presentation.2019
- Author(s)
  Taeko Kimura, Chie Seki, Kazuaki Sampei, Jun Maeda, Maiko Ono, Tetsuya Suhara, Ming-Rong Zhang, Naruhiko Sahara and Makoto Higuchi
- Organizer
  The 29th international symposium on cerebral blood flow, metabolism and function. The 14th international conference on quantification of Brain function with PET.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07113
[Presentation] Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy.2018
- Author(s)
  木村妙子
- Organizer
  第40回日本生物学的精神医学会　第61回日本神経化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07113
[Presentation] タウモデルマウスを用いた新規タウPETリガンド[18F]PM-PBB3の有用性2018
- Author(s)
  木村妙子
- Organizer
  新学術領域研究脳タンパク質老化と認知症制御第８回班員会議・第４回リトリート
- Data Source
  KAKENHI-PROJECT-17K07113
[Presentation] タウモデルマウスを用いた新規タウPETリガンド[18F]PM-PBB3の有用性2018
- Author(s)
  木村妙子
- Organizer
  第37回日本認知症学会学
- Data Source
  KAKENHI-PROJECT-17K07113
[Presentation] Development of in vivo imaging platform for investigating pathological tau propagation2017
- Author(s)
  木村妙子
- Organizer
  新学術領域研究「脳タンパク質老化と認知症制御」第2回国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07113
[Presentation] 複雑怪奇なリン酸化タンパク質タウのPhos-Tag解析2017
- Author(s)
  木村妙子,久永眞市
- Organizer
  第68回日本電気泳動学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07113
[Presentation] Tauは細胞内で多様なリン酸化状態として存在する2016
- Author(s)
  木村妙子、石黒幸一、長谷川成人、久永眞市
- Organizer
  第59回日本神経化学会
- Place of Presentation
  福岡
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-15K18366
[Presentation] Tauは細胞内で多様なリン酸化状態として存在する2016
- Author(s)
  木村妙子、久永眞市
- Organizer
  第4回新学術班会議
- Place of Presentation
  千葉
- Year and Date
  2016-06-03
- Data Source
  KAKENHI-PROJECT-15K18366
[Presentation] New insights in quantitative analysis of phosphorylation of Tau in AD model mouse and Tauopathy brains by Phos-tag SDS-PAGE.2015
- Author(s)
  Taeko Kimura
- Organizer
  25th meeting of the International society for neurochemistry
- Place of Presentation
  Cairns, Australia
- Year and Date
  2015-08-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18366
[Presentation] Phos-tag SDS-PAGE法による神経変性疾患タウのリン酸化解析2015
- Author(s)
  木村妙子
- Organizer
  第66回電気泳動学会
- Place of Presentation
  東京
- Year and Date
  2015-09-04
- Invited
- Data Source
  KAKENHI-PROJECT-15K18366
[Presentation] The abundance of nonphosphorylated tau among heterogeneously phosphorylated tau species in vivo in mouse and human tauopathy brains2015
- Author(s)
  Taeko Kimura
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  埼玉
- Year and Date
  2015-09-11
- Invited
- Data Source
  KAKENHI-PROJECT-15K18366
[]

1. 久永眞市 (20181092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. 富田泰輔 (30292957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. 堀由起子 (80610683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 高鳥翔 (80624361)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. MATSUMOTO Gen

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kimura Taeko 木村 妙子

KIMURA TAEKO 木村 妙子

Research Projects

Research Products

Co-Researchers

中枢神経系プロテイノパチー発症機構の統合的解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

外傷性脳損傷モデルを用いたタウオパチー病理メカニズム解明への新規アプローチPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Tauopathy Analysis of tau phosphorylation specific to neurodegenerative diseases and elucidation of pathogenic factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel quantitative analysis of abnormal phosphorylated tauPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] タウオパチー神経変性疾患と脳内炎症2020

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers2024

Author(s)

Journal Title

Data Source

[Journal Article] Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tau isoform expression and phosphorylateion in marmotset brains.2019

Author(s)

Journal Title

Data Source

[Journal Article] Pathological progression induced by the frontotemporal dementia-associated R406W tau mutation in patient-derived iPSCs.2019

Author(s)

Journal Title

Data Source

[Journal Article] Tau Fibril Formation in Cultured Cells Compatible with a Mouse Model of Tauopathy2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy2018

Author(s)

Journal Title

Data Source

[Journal Article] Biochemical Properties of Pathology-Related Tau Species in Tauopathy Brains: An Extraction Protocol for Tau Oligomers and Aggregates2018

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Phos-tag SDS-PAGE analysis of complicated phosphorylation of a neurodegenerative disease protein tau2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

Kimura Taeko 木村妙子

KIMURA TAEKO 木村妙子