AYAKI TAKASHI 綾木孝

… Alternative Names

ayaki takashi 綾木孝

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Researcher Number	60749555
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 助教 2025: 和歌山県立医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2020 – 2023: 京都大学, 医学研究科, 助教 2015 – 2019: 京都大学, 医学研究科, 特定病院助教
Review Section/Research Field	Principal Investigator Basic Section 46020:Anatomy and histopathology of nervous system-related / Nerve anatomy/Neuropathology Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / Nerve anatomy/Neuropathology
Keywords	Principal Investigator インフラマソーム / ミクログリア / 自然免疫 / STING / IL1β / NLRP3 / α-シヌクレイン / 神経変性疾患 / NFκB / 筋萎縮性側索硬化症 … More / 選択的オートファジー / 神経炎症 / 活性型カスパーゼ3 / 直鎖状ユビキチン鎖 / 顆粒空胞変性 / NF kappa B / OPTN / 直鎖型ユビキチン / 顆粒空砲変性 / NLRP3インフラマソーム / 神経細胞死 / multiple proteinopathy / NF-кB / optineurin … More Except Principal Investigator 7 tesla MRI / 記憶障害 / タウ / アミロイドβ / マイネルト基底核 / 側頭葉皮質 / 嗅内野 / 7テスラMRI / 遺伝子解析 / 神経病理 / 神経炎症 / タンパク分解系 / ポリユビキチン鎖 / 神経科学 / ポリユビキチン / TDP-43 / タウタンパク / 紀伊半島 / パーキンソン認知症複合 / 筋萎縮性側索硬化症 Less

Where does the degeneration in Alzheimer's disease begin, and how are memory impairments caused?
- Principal Investigator
  
  Nobukatsu Sawamoto
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Kyoto University
Exploring inflammasome-mediated neuroimmune regulation in Parkinson's disease and multiple system atrophyPrincipal Investigator
- Principal Investigator
  
  Takashi Ayaki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Kyoto University
Pathological and cytological sesearch of neurodegenerative diseases and earch for therapeutic drug candidates based on OPTN dysfunctionPrincipal Investigator
- Principal Investigator
  
  ayaki takashi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Kyoto University
Creation of ALS treatment seed by latest comprehensive neuroscience research for Kii ALS/PDC
- Principal Investigator
  
  Ito Hidefumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Wakayama Medical University

All 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers.2022
- Author(s)
  1.Jin M., Matsumoto S., Ayaki T., Yamakado H., Taguchi T., Togawa N., Konno A., Hirai H., Nakajima H., Komai S., Ishida R., Chiba S., Takahashi R., Takao T. and Hirotsune S.
- Journal Title
  
  Nature Communications
  
  Volume: 13(1):6880 Issue: 1 Pages: 6880-6880
- DOI
  10.1038/s41467-022-34555-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06821, KAKENHI-PROJECT-22K06207, KAKENHI-PROJECT-22K06887, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-19K06899, KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-22K06454
[Journal Article] Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): A multicentre, open-label, dose-escalation phase 1 trial2022
- Author(s)
  Imamura K、Izumi Y、Nagai M、Nishiyama K、Watanabe Y、Hanajima R、Egawa N、Ayaki T、Oki R、Fujita K、Uozumi R、Morinaga A、Hirohashi T、Fujii Y、Yamamoto T、Tatebe H、Tokuda T、Takahashi N、Morita S、Takahashi R、Inoue H
- Journal Title
  
  eClinicalMedicine
  
  Volume: 53 Pages: 101707-101707
- DOI
  10.1016/j.eclinm.2022.101707
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07883, KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-20K07867
[Journal Article] An autopsy case of adult‐onset neuronal intranuclear inclusion disease with perivascular preservation in cerebral white matter2022
- Author(s)
  Yoshii Daisuke、Ayaki Takashi、Wada Takafumi、Ozaki Akihiko、Yamamoto Toru、Miyagi Yoshimi、Senzaki Hideto、Takahashi Ryosuke
- Journal Title
  
  Neuropathology
  
  Volume: 42 Issue: 1 Pages: 66-73
- DOI
  10.1111/neup.12778
- Data Source
  KAKENHI-PROJECT-19K16277
[Journal Article] Failure of DNA double-strand break repair by tau mediates Alzheimer’s disease pathology in vitro2022
- Author(s)
  Asada-Utsugi Megumi、Uemura Kengo、Ayaki Takashi、T. Uemura Maiko、Minamiyama Sumio、Hikiami Ryota、Morimura Toshifumi、Shodai Akemi、Ueki Takatoshi、Takahashi Ryosuke、Kinoshita Ayae、Urushitani Makoto
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 00-00
- DOI
  10.1038/s42003-022-03312-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03573, KAKENHI-PROJECT-20K06391, KAKENHI-PROJECT-19K16277
[Journal Article] Conformational change of RNA-helicase DHX30 by ALS/FTD-linked FUS induces mitochondrial dysfunction and cytosolic aggregates2022
- Author(s)
  Hikiami R, Morimura T, Ayaki T, Tsukiyama T, Morimura N, Kusui M, Wada H, Minamiyama S, Shodai A, Asada-Utsugi M, Muramatsu SI, Ueki T, Takahashi R, Urushitani M.
- Journal Title
  
  Scxeintific Reports
  
  Volume: 12 Issue: 1 Pages: 16030-16046
- DOI
  10.1038/s41598-022-20405-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06391, KAKENHI-PROJECT-22K06429, KAKENHI-PROJECT-22K19246, KAKENHI-ORGANIZER-20H05760, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-23K23794, KAKENHI-PROJECT-23K24211
[Journal Article] White matter edematous change with moderate vascular lesions in pretreated acute stage of leukoencephalopathy with cerebral amyloid angiopathy2022
- Author(s)
  Yasuda Ken、Ayaki Takashi、Li Fangzhou、Kuwata Yasuhiro、Maki Takakuni、Sainouchi Makoto、Moriyoshi Koki、Nakamura Michikazu、Takahashi Ryosuke
- Journal Title
  
  Neuropathology
  
  Volume: 42 Issue: 2 Pages: 134-140
- DOI
  10.1111/neup.12782
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22683, KAKENHI-PROJECT-19K16277
[Journal Article] The stimulator of interferon genes (STING) pathway is upregulated in striatal astrocytes of patients with multiple system atrophy2021
- Author(s)
  Inoue Yutaka、Ayaki Takashi、Ishimoto Tomoyuki、Yamakado Hodaka、Maki Takakuni、Matsuzawa Shuichi、Sawamoto Nobukatsu、Takahashi Ryosuke
- Journal Title
  
  Neuroscience Letters
  
  Volume: 757 Pages: 135972-135972
- DOI
  10.1016/j.neulet.2021.135972
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22964, KAKENHI-PROJECT-20H00663, KAKENHI-PROJECT-20K21573, KAKENHI-PROJECT-21K19447, KAKENHI-PROJECT-23K21585
[Journal Article] Optineurin defects cause TDP43-pathology with autophagic vacuolar formation.2021
- Author(s)
  Kurashige T, Kuramochi M, Ohsawa R, Yamashita Y, Shioi G, Morino H, Kamada M, Ayaki T, Ito H, Sotomaru Y, Maruyama H, Kawakami H.
- Journal Title
  
  Neurobiol Dis
  
  Volume: 148 Pages: 105215-105215
- Data Source
  KAKENHI-PROJECT-19K16277
[Journal Article] Monoclonal gammopathy of renal significance (MGRS)-related AL amyloidosis complicated by amyloid myopathy: a case report2021
- Author(s)
  Ono Erina、Ishii Akira、Higashi Yoshiaki、Koita Natsuko、Ayaki Takashi、Tanigaki Katsuya、Takayanagi Shunsuke、Kondo Naoya、Sakai Kaoru、Endo Shuichiro、Yokoi Hideki、Matsubara Takeshi、Minamiguchi Sachiko、Nishino Ichizo、Takahashi Ryosuke、Yanagita Motoko
- Journal Title
  
  BMC Nephrology
  
  Volume: 22 Issue: 1 Pages: 74-74
- DOI
  10.1186/s12882-021-02272-7
- Data Source
  KAKENHI-PROJECT-19K16277
[Journal Article] Optineurin defects cause TDP43-pathology with autophagic vacuolar formation2021
- Author(s)
  Kurashige Takashi、Kuramochi Masahito、Ohsawa Ryosuke、Yamashita Yui、Shioi Go、Morino Hiroyuki、Kamada Masaki、Ayaki Takashi、Ito Hidefumi、Sotomaru Yusuke、Maruyama Hirofumi、Kawakami Hideshi
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 148 Pages: 105215-105215
- DOI
  10.1016/j.nbd.2020.105215
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07887, KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-18H02743, KAKENHI-PROJECT-19H01056
[Journal Article] The stimulator of interferon genes (STING) pathway is upregulated in striatal astrocytes of patients with multiple system atrophy2021
- Author(s)
  Yutaka Inoue, Takashi Ayaki, Tomoyuki Ishimoto, Hodaka Yamakado, Takakuni Maki , Shuichi Matsuzawa, Nobukatsu Sawamoto, Ryosuke Takahashi
- Journal Title
  
  Neurosci Lett .
  
  Volume: 757 Pages: 135972-135972
- Data Source
  KAKENHI-PROJECT-19K16277
[Journal Article] Insertable inductively coupled volumetric coils for MR microscopy in a human 7T MR system2021
- Author(s)
  Okada Tomohisa、Handa Shinya、Ding Bill、Urayama Shin‐ichi、Fujimoto Koji、Shima Atsushi、Yoshii Daisuke、Ayaki Takashi、Sawamoto Nobukatsu、Takahashi Ryosuke、Onoe Hirotaka、Isa Tadashi、Petropoulos Labros
- Journal Title
  
  Magnetic Resonance in Medicine
  
  Volume: 87 Issue: 3 Pages: 1613-1620
- DOI
  10.1002/mrm.29062
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20719, KAKENHI-PROJECT-20K21573, KAKENHI-PROJECT-21K19447, KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-20H00573, KAKENHI-PROJECT-23K21585
[Journal Article] BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy2020
- Author(s)
  Kaji S, Maki T, Ueda J, Ishimoto T, Inoue Y, Yasuda K, Sawamura M, Hikawa R, Ayaki T, Yamakado H, Takahashi R
- Journal Title
  
  Acta Neuropathol Commun. 2020 Jul 29;8(1):120. doi: 10.1186/s40478-020-00997-4. PMID: 32727582; PMCID: PMC7391509
  
  Volume: 8 Issue: 1 Pages: 120-120
- DOI
  10.1186/s40478-020-00997-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22964, KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-20H00663
[Journal Article] a-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia:a prodromal Parkinson’s disease model2020
- Author(s)
  Taguchi T, Ikuno M, Hondo M, Parajuli LK, Taguchi K, Ueda J, Sawamura M, Okuda S, Nakanishi E, Hara J, Uemura N, Hatanaka Y, Ayaki T, Matsuzawa S, Tanaka M, El-Agnaf OMA, Koike M, Yanagisawa M, Uemura MT, Yamakado H, Takahashi R
- Journal Title
  
  BRAIN
  
  Volume: 143 Issue: 1 Pages: 249-265
- DOI
  10.1093/brain/awz380
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14842, KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-17H03553, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-16K18987, KAKENHI-PROJECT-18H04041, KAKENHI-PROJECT-16K09672
[Journal Article] Myositis with sarcoplasmic inclusions in Nakajo‐Nishimura syndrome: a genetic inflammatory myopathy2020
- Author(s)
  Takashi Ayaki、Kenya Murata、Kanazawa Nobuo、Akinori Uruha、Koichiro Ohmura、Kazuma Sugie、Shimpei Kasagi、Fangzhou Li、Megumi Mori、Nakajima Ran、Sasai Tsuneo、Nishino Ichizo、Satoshi Ueno、Makoto Urushitani、Fukumi Furukawa、Ito Hidefumi、Takahashi Ryosuke
- Journal Title
  
  Neuropathology and Applied Neurobiology
  
  Volume: 00 Issue: 6 Pages: 00-00
- DOI
  10.1111/nan.12614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03573, KAKENHI-PROJECT-19K08798, KAKENHI-PROJECT-19K16277
[Journal Article] Accumulation of HAX-1 and PARL in brainstem- and cortical-type Lewy bodies in Parkinson's disease and dementia with Lewy bodies2020
- Author(s)
  Kawamoto Yasuhiro、Ayaki Takashi、Urushitani Makoto、Ito Hidefumi、Takahashi Ryosuke
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 415 Pages: 116928-116928
- DOI
  10.1016/j.jns.2020.116928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-19H03573
[Journal Article] Japanese Familial Cases of Frontotemporal Dementia and Parkinsonism with N279K Tau Gene Mutation2020
- Author(s)
  Oka Yuwa、Saiki Hidemoto、Hashimoto Yasumasa、Terada Yuta、Nakamura Takashi、Ayaki Takashi、Orimo Satoshi、Matsumoto Sadayuki
- Journal Title
  
  Movement Disorders Clinical Practice
  
  Volume: 8 Issue: 1 Pages: 126-132
- DOI
  10.1002/mdc3.13100
- Data Source
  KAKENHI-PROJECT-19K16277
[Journal Article] Identification of linear polyubiquitin chain immunoreactivity in tau pathology of Alzheimer’s disease2019
- Author(s)
  Nakayama Yoshiaki、Sakamoto Shinji、Tsuji Kazumi、Ayaki Takashi、Tokunaga Fuminori、Ito Hidefumi
- Journal Title
  
  Neuroscience Letters
  
  Volume: 703 Pages: 53-57
- DOI
  10.1016/j.neulet.2019.03.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-18H02743, KAKENHI-PROJECT-16K18383, KAKENHI-PROJECT-19K22541, KAKENHI-PROJECT-19K16277, KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-16K09729
[Journal Article] Induced pluripotent stem cell?based Drug Repurposing for Amyotrophic lateral sclerosis Medicine (iDReAM) study: protocol for a phase I dose escalation study of bosutinib for amyotrophic lateral sclerosis patients2019
- Author(s)
  Imamura Keiko、Izumi Yuishin、Banno Haruhiko、Uozumi Ryuji、Morita Satoshi、Egawa Naohiro、Ayaki Takashi、、et al.
- Journal Title
  
  BMJ Open
  
  Volume: 9 Issue: 12 Pages: e033131-e033131
- DOI
  10.1136/bmjopen-2019-033131
- NAID
  120006826750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-17H04040, KAKENHI-PROJECT-18K15347
[Journal Article] Phosphorylated NF-κB subunit p65 aggregates in granulovacuolar degeneration and neurites in neurodegenerative diseases with tauopathy2019
- Author(s)
  Yamaguchi Yuko、Ayaki Takashi、Li Fangzhou、Tsujimura Atsushi、Kamada Masaki、Ito Hidefumi、Maki Takakuni、Sawamoto Nobukatsu、Urushitani Makoto、Takahashi Ryosuke
- Journal Title
  
  Neuroscience Letters
  
  Volume: 704 Pages: 229-235
- DOI
  10.1016/j.neulet.2019.03.036
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-16K18383, KAKENHI-PROJECT-19K16277
[Journal Article] Two cases of delayed perforating artery infarction adjacent to intracranial hemorrhage2019
- Author(s)
  Yasuda Ken、Maki Takakuni、Kimura Kimitoshi、Ayaki Takashi、Sawamoto Nobukatsu、Murase Nagako、Ohtani Ryo、Takahashi Ryosuke、Nakamura Michikazu
- Journal Title
  
  eNeurologicalSci
  
  Volume: 17 Pages: 100209-100209
- DOI
  10.1016/j.ensci.2019.100209
- Data Source
  KAKENHI-PROJECT-19K16277
[Journal Article] Linear Polyubiquitin Chain Modification of TDP-43-Positive Neuronal Cytoplasmic Inclusions in Amyotrophic Lateral Sclerosis2019
- Author(s)
  Nakayama Yoshiaki、Tsuji Kazumi、Ayaki Takashi、Mori Megumi、Tokunaga Fuminori、Ito Hidefumi
- Journal Title
  
  Journal of Neuropathology & Experimental Neurology
  
  Volume: 79 Issue: 3 Pages: 256-265
- DOI
  10.1093/jnen/nlz135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22541, KAKENHI-PROJECT-19K16277, KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-18H02743, KAKENHI-PROJECT-16K09729
[Journal Article] An autopsy case after endovascular thrombectomy for cardioembolic stroke due to nonbacterial thrombotic endocarditis2019
- Author(s)
  Yasuda K, Ayaki T, Kawabata Y, Murase N, Ohtani R, Nakamura M.
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 59 Issue: 4 Pages: 195-199
- DOI
  10.5692/clinicalneurol.cn-001252
- NAID
  130007636894
- ISSN
  0009-918X, 1882-0654
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19871, KAKENHI-PROJECT-19K16277
[Journal Article] Role of Perivascular Oligodendrocyte Precursor Cells in Angiogenesis After Brain Ischemia2019
- Author(s)
  Kishida Natsue、Maki Takakuni、Takagi Yasushi、Yasuda Ken、Kinoshita Hisanori、Ayaki Takashi、Noro Takayuki、Kinoshita Yusuke、Ono Yuichi、Kataoka Hiroharu、Yoshida Kazumichi、Lo Eng H.、Arai Ken、Miyamoto Susumu、Takahashi Ryosuke
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 8 Issue: 9
- DOI
  10.1161/jaha.118.011824
- NAID
  120006980544
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-19K16277
[Journal Article] Chronic cerebral hypoperfusion upregulates leptin receptor expression in astrocytes and tau phosphorylation in tau transgenic mice.2019
- Author(s)
  Shimada T, Shindo A, Matsuyama H, Yata K, Niwa A, Sasaki R, Ayaki T, Maki T, Wakita H, Tomimoto H.
- Journal Title
  
  Neuroscience Letters
  
  Volume: 704 Pages: 133-140
- DOI
  10.1016/j.neulet.2019.04.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09684, KAKENHI-PROJECT-16K15246, KAKENHI-PROJECT-18K16557, KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-19H03572
[Journal Article] Recurrent Epstein-Barr Virus-positive (EBV+) Primary Central Nervous System Lymphoma (PCNSL) in a Patient with Clinical Features of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS)2019
- Author(s)
  Nagano Masahiro、Ayaki Takashi、Koita Natsuko、Kitano Toshiyuki、Nishikori Momoko、Goda Naoki、Minamiguchi Sachiko、Ikeda Akio、Takaori-Kondo Akifumi、Takahashi Ryosuke
- Journal Title
  
  Intern. Med.
  
  Volume: 58 Issue: 6 Pages: 849-854
- DOI
  10.2169/internalmedicine.1246-18
- NAID
  130007611374
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2019-03-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08324, KAKENHI-PROJECT-19K16277, KAKENHI-ORGANIZER-15H05871, KAKENHI-PLANNED-15H05874, KAKENHI-INTERNATIONAL-15K21731, KAKENHI-PROJECT-19H03574
[Journal Article] Myotonic dystrophy type 1 with diabetes mellitus, mixed hypogonadism and adrenal insufficiency2018
- Author(s)
  Takeshima Ken、Ariyasu Hiroyuki、Ishibashi Tatsuya、Kawai Shintaro、Uraki Shinsuke、Koh Jinsoo、Ito Hidefumi、Akamizu Takashi
- Journal Title
  
  Endocrinology, Diabetes and Metabolism Case Reports
  
  Volume: 17 Pages: 1-6
- DOI
  10.1530/edm-17-0143
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04270
[Journal Article] Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals.2018
- Author(s)
  Tamaki Y, Shodai A, Morimura T, Hikiami R, Minamiyama S, Ayaki T, Tooyama I, Furukawa Y, Takahashi R, Urushitani M.
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中 Issue: 1 Pages: 6030-6030
- DOI
  10.1038/s41598-018-24463-3
- NAID
  120006482849
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08077, KAKENHI-PROJECT-26290023, KAKENHI-PUBLICLY-17H05705, KAKENHI-PUBLICLY-18H04564, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-16K18383
[Journal Article] Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy2018
- Author(s)
  Kaji Seiji、Maki Takakuni、Kinoshita Hisanori、Uemura Norihito、Ayaki Takashi、Kawamoto Yasuhiro、Furuta Takahiro、Urushitani Makoto、Hasegawa Masato、Kinoshita Yusuke、Ono Yuichi、Mao Xiaobo、Quach Tran H.、Iwai Kazuhiro、Dawson Valina L.、Dawson Ted M.、Takahashi Ryosuke
- Journal Title
  
  Stem Cell Rep
  
  Volume: 10 Issue: 2 Pages: 356-365
- DOI
  10.1016/j.stemcr.2017.12.001
- NAID
  120006414715
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290023, KAKENHI-PUBLICLY-17H05698, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-15H04266, KAKENHI-PROJECT-16K18383
[Journal Article] FKBP12-immunopositive inclusions in patients with α-synucleinopathies2018
- Author(s)
  Honjo Yasuyuki、Ayaki Takashi、Horibe Tomohisa、Ito Hidefumi、Takahashi Ryosuke、Kawakami Koji
- Journal Title
  
  Brain Research
  
  Volume: 1680 Pages: 39-45
- DOI
  10.1016/j.brainres.2017.12.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04270
[Journal Article] NLRP3 Inflammasome-Related Proteins Are Upregulated in the Putamen of Patients With Multiple System Atrophy2018
- Author(s)
  Li Fangzhou、Ayaki Takashi、Maki Takakuni、Sawamoto Nobukatsu、Takahashi Ryosuke
- Journal Title
  
  Journal of Neuropathology & Experimental Neurology
  
  Volume: 77 Issue: 11 Pages: 1055-1065
- DOI
  10.1093/jnen/nly090
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-16K18383
[Journal Article] Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl2018
- Author(s)
  Hikiami Ryota、Yamakado Hodaka、Tatsumi Shinsui、Ayaki Takashi、Hashi Yuichiro、Yamashita Hirofumi、Sawamoto Nobukatsu、Tsuji Teruyuki、Urushitani Makoto、Takahashi Ryosuke
- Journal Title
  
  Intern. Med.
  
  Volume: 57 Issue: 13 Pages: 1917-1919
- DOI
  10.2169/internalmedicine.0285-17
- NAID
  130007387154
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2018-07-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26290023, KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-16K18383, KAKENHI-PROJECT-16K09672
[Journal Article] Decreased levels of PDI and P5 in oligodendrocytes in Alzheimer's disease2017
- Author(s)
  Honjo Yasuyuki、Ayaki Takashi、Tomiyama Takami、Horibe Tomohisa、Ito Hidefumi、Mori Hiroshi、Takahashi Ryosuke、Kawakami Koji
- Journal Title
  
  Neuropathology
  
  Volume: 37 Issue: 6 Pages: 495-501
- DOI
  10.1111/neup.12395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18383, KAKENHI-PROJECT-15H04270
[Journal Article] Three-year follow-up of high-dose ubiquinol supplementation in a case of familial multiple system atrophy with compound heterozygous COQ2 mutations.2017
- Author(s)
  Mitsui J, Koguchi K, Momose T, Takahashi M, Matsukawa T, Yasuda T, Tokushige S, Ishiura H, Goto J, Nakazaki S, Kondo T, Ito H, Yamamoto Y and Tsuji S.
- Journal Title
  
  Cerebellum
  
  Volume: - Issue: 3 Pages: 1-9
- DOI
  10.1007/s12311-017-0846-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253054, KAKENHI-PROJECT-26350915, KAKENHI-PROJECT-17H06159, KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-15K09334
[Journal Article] Multiple proteinopathies in familial ALS cases with optineurin mutation.2017
- Author(s)
  Ayaki T, Ito H, Komure O, Kamada M, Nakamura M, Wate R, Kusaka H, Yamaguchi Y, Li F, Kawakami H, Urushitani M, Takahashi R
- Journal Title
  
  J Neuropathol Exp Neurol
  
  Volume: 77 Issue: 2 Pages: 128-138
- DOI
  10.1093/jnen/nlx109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26290023, KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-16K15481, KAKENHI-PROJECT-16K18383
[Journal Article] Activated caspase-9 immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy.2016
- Author(s)
  Kawamoto Y, Ayaki T, Urushitani M, Ito H, Takahashi R.
- Journal Title
  
  Neurosci Lett.
  
  Volume: 628 Pages: 207-212
- DOI
  10.1016/j.neulet.2016.06.036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-26290023, KAKENHI-PROJECT-16K18383
[Journal Article] Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.2016
- Author(s)
  Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, and Tokunaga F.
- Journal Title
  
  Nat. Commun.
  
  Volume: 7 Issue: 1 Pages: 12547-12547
- DOI
  10.1038/ncomms12547
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-16H01192, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-25291011, KAKENHI-PROJECT-15K18468, KAKENHI-PROJECT-15K08259, KAKENHI-PROJECT-16K15210, KAKENHI-PROJECT-16K18383
[Journal Article] CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS.2016
- Author(s)
  Uchida T, Tamaki Y, Ayaki T, Shodai A, Kaji S, Morimura T, Banno Y, Nishitsuji K, Sakashita N, Maki T, Yamashita H, Ito H, Takahashi R, Urushitani M.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 19118-19136
- DOI
  10.1038/srep19118
- NAID
  120005689210
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26450403, KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-26670190, KAKENHI-PROJECT-24300132, KAKENHI-PROJECT-26290023, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-15K19488, KAKENHI-PROJECT-16K08712
[Journal Article] Increased GADD34 in oligodendrocytes in Alzheimer's disease.2015
- Author(s)
  Honjo Y, Ayaki T, Tomiyama T, Horibe T, Ito H, Mori H, Takahashi R, Kawakami K.
- Journal Title
  
  Neurosci Lett.
  
  Volume: 602 Pages: 50-55
- DOI
  10.1016/j.neulet.2015.06.052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-24300132, KAKENHI-PROJECT-25290018, KAKENHI-PLANNED-23111002
[Presentation] 痙性対麻痺を呈した新規presenilin-1遺伝子変異による家族性アルツハイマー病の剖検例2018
- Author(s)
  大井由貴、井谷理彦、長谷川華子、眞木崇州、葛谷聡、山下博史、綾木孝、山内浩、丹羽篤、高屋成利、岡田知久、李方舟、酒巻春日、澤本伸克、松本理器、池田昭夫、冨本秀和、髙橋良輔
- Organizer
  第46回　臨床神経病理懇話会
- Data Source
  KAKENHI-PROJECT-16K18383
[Presentation] 浮腫を背景とした、脳アミロイドアンギオパチー関連脳症の一剖検例2018
- Author(s)
  安田謙、綾木孝、桑田康弘、眞木崇州、中村道三、高橋良輔
- Organizer
  第17回日本神経病理学会近畿地方会
- Data Source
  KAKENHI-PROJECT-16K18383
[Presentation] 運動失調・錐体外路兆候、認知機能低下を呈し、小脳プルキンエ細胞と大脳にp62陽性核内封入体を認めた剖検例2017
- Author(s)
  綾木　孝ら
- Organizer
  第16回日本神経病理学会近畿地方会
- Data Source
  KAKENHI-PROJECT-16K18383
[Presentation] Myositis and muscular inclusions in Nakajo-Nishimura syndrome2017
- Author(s)
  Ayaki T, Ito H, et al
- Organizer
  XXIII World Congress of Neurology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04270
[Presentation] 被殻にヘモジデリン貪食ミクログリアを多数認めた多系統萎縮症の剖検例2017
- Author(s)
  李　方舟、綾木　孝ら
- Organizer
  第45回　臨床神経病理懇話会
- Data Source
  KAKENHI-PROJECT-16K18383
[Presentation] 運動ニューロン病、前頭葉側頭葉認知症とパーキンソニズムを呈した高齢発症の神経中間径フィラメント封入体病（NIFID）の一剖検例2017
- Author(s)
  李　方舟、綾木　孝ら
- Organizer
  第15回日本神経病理学会近畿地方会
- Data Source
  KAKENHI-PROJECT-16K18383
[Presentation] 胃腸症状の後に四肢呼吸筋麻痺のため4か月の経過で死亡し、SOD陽性封入体を認めSOD関連ALS が疑われた剖検例2016
- Author(s)
  山口裕子，綾木孝，辰己新水，山下博史，漆谷真，高橋良輔
- Organizer
  第44回臨床神経病理懇話会・第14回日本神経病理学会近畿地方会
- Place of Presentation
  大阪大学
- Year and Date
  2016-11-19
- Data Source
  KAKENHI-PROJECT-16K18383
[Presentation] 抗ARS抗体陽性筋炎の臨床病理学的検討2016
- Author(s)
  中山宜昭、樽谷潤子、細川万生、安井昌彰、綾木孝、村田顕也、鈴木重明、伊東秀文
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター・神戸ポートピアホテル
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-15H04270
[Presentation] The development of therapeutic intrabody against misfolded TDP-43 for ALS2016
- Author(s)
  Tamaki Y, Shodai A, Hikiami R, Minamiyama S, Ayaki T, Takahashi R, Urushitani M.
- Organizer
  Annual Meeting of Society for Neuroscience
- Place of Presentation
  サンディエゴ
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18383
[Presentation] 和歌山県にて近年発症した紀伊ALSの一剖検例2016
- Author(s)
  中山宜昭、辻郁在、綾木孝、廣西昌也、村田顕也、森野豊之、川上秀史、伊東秀文、
- Organizer
  第57回日本神経病理学会総会学術研究会
- Place of Presentation
  ホテルニューキャッスル（弘前）
- Year and Date
  2016-06-03
- Data Source
  KAKENHI-PROJECT-15H04270
[Presentation] パーキンソニズムの加療中に認知症,筋萎縮性側索硬化症を発症した一剖検例2016
- Author(s)
  島淳,綾木孝, 奥宮太郎, 辰巳新水, 田中寛大, 末長敏彦, 漆谷真, 高橋良輔
- Organizer
  第57回日本神経病理学会総会学術研究会
- Place of Presentation
  弘前市ホテルニューキャッスル
- Year and Date
  2016-06-01
- Data Source
  KAKENHI-PROJECT-16K18383
[Presentation] VHLとCUL2；TDP-43の凝集を促進するVHLと分解を促進するCUL22015
- Author(s)
  内田司、小代明美、玉木良高、辰己新水、守村敏史、綾木孝、伊東秀文、坂下直実、髙橋良輔、漆谷真
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟コンベンションセンター）・ホテル日航新潟
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-15H04270
[Presentation] Optineurin遺伝子にヘテロ接合E478G変異を認めた家族性ALSの一剖検例2015
- Author(s)
  綾木孝、伊東秀文、小牟禮修、辰己新水、漆谷真、川上秀史、髙橋良輔
- Organizer
  第56回日本神経病理学会総会学術研究会
- Place of Presentation
  九州大学医学部百年講堂
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-15H04270
[Presentation] 抗ganglionic acetylcholine receptor抗体陽性AAGの臨床的多様性について2015
- Author(s)
  中山宜昭、髙橋麻衣子、綾木孝、村田顕也、中根俊成、樋口理、松尾秀徳、伊東秀文
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟コンベンションセンター）・ホテル日航新潟
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-15H04270

1. Ito Hidefumi (20250061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
2. ISHIGUCHI Hiroshi (70389443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KAWAKAMI Hideshi (70253060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. TAKAHASHI Ryosuke (90216771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. INOUE Haruhisa (70332327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Nobukatsu Sawamoto (90397547)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 紀平為子 (30225015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中山宜昭 (50590436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 廣西昌也 (80316116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MITSUI Jun

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. WAKITA Hideaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 金明月

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 山門穗高

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 徳永文稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
15. 江川斉宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 守村敏史

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
17. パラジュリラクシミ・クマール

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 漆谷真

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
19. 辻省次

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 後藤順

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 丸山博文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 広西昌也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 藤本晃司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 安田謙

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AYAKI TAKASHI 綾木 孝

ayaki takashi 綾木 孝

Research Projects

Research Products

Co-Researchers

Where does the degeneration in Alzheimer's disease begin, and how are memory impairments caused?

Principal Investigator

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Review Section

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Exploring inflammasome-mediated neuroimmune regulation in Parkinson's disease and multiple system atrophyPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Pathological and cytological sesearch of neurodegenerative diseases and earch for therapeutic drug candidates based on OPTN dysfunctionPrincipal Investigator

Principal Investigator

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Research Institution

Creation of ALS treatment seed by latest comprehensive neuroscience research for Kii ALS/PDC

Principal Investigator

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[Journal Article] DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers.2022

Author(s)

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DOI

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[Journal Article] Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): A multicentre, open-label, dose-escalation phase 1 trial2022

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DOI

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[Journal Article] An autopsy case of adult‐onset neuronal intranuclear inclusion disease with perivascular preservation in cerebral white matter2022

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[Journal Article] Failure of DNA double-strand break repair by tau mediates Alzheimer’s disease pathology in vitro2022

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[Journal Article] Conformational change of RNA-helicase DHX30 by ALS/FTD-linked FUS induces mitochondrial dysfunction and cytosolic aggregates2022

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DOI

Data Source

[Journal Article] White matter edematous change with moderate vascular lesions in pretreated acute stage of leukoencephalopathy with cerebral amyloid angiopathy2022

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[Journal Article] The stimulator of interferon genes (STING) pathway is upregulated in striatal astrocytes of patients with multiple system atrophy2021

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[Journal Article] Optineurin defects cause TDP43-pathology with autophagic vacuolar formation.2021

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[Journal Article] Monoclonal gammopathy of renal significance (MGRS)-related AL amyloidosis complicated by amyloid myopathy: a case report2021

Author(s)

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DOI

Data Source

[Journal Article] Optineurin defects cause TDP43-pathology with autophagic vacuolar formation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The stimulator of interferon genes (STING) pathway is upregulated in striatal astrocytes of patients with multiple system atrophy2021

Author(s)

AYAKI TAKASHI 綾木孝

ayaki takashi 綾木孝