OTSUKA Tsuyoshi 大塚剛司

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Otsuka Tsuyoshi 大塚剛司

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Researcher Number	60760395
Other IDs
Affiliation (Current)	2025: 岐阜大学, 応用生物科学部, 准教授
Affiliation (based on the past Project Information) *help	2024: 岐阜大学, 応用生物科学部, 助教 2018 – 2020: 岐阜大学, 応用生物科学部, 助教 2017: 和歌山県立医科大学, 医学部, 特別研究員 2015 – 2017: 和歌山県立医科大学, 医学部, 学内助教
Review Section/Research Field	Principal Investigator Basic Section 08030:Family and consumer sciences, and culture and living-related / Basic Section 52030:Psychiatry-related / Psychiatric science Except Principal Investigator Environmental physiology(including physical medicine and nutritional physiology)
Keywords	Principal Investigator 脳 / セロトニン / 時計遺伝子 / 精神疾患 / 動物性タンパク質欠乏 / 脳-腸相関 / ヴィーガン / インスリン感受性 / 情動行動 / コリン作動性ニューロン … More / 睡眠覚醒 / ChAT / Bmal1 / Rev-erb α / 双極性障害 / 前頭前皮質 / 情動障害 / Rev-erbα … More Except Principal Investigator ミトコンドリア / 時計遺伝子 / 心不全 Less

ヴィーガンモデル動物を用いた脳腸相関に基づく精神疾患発症機序の解明Principal Investigator
- Principal Investigator
  
  大塚剛司
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 08030:Family and consumer sciences, and culture and living-related
- Research Institution
  Gifu University
The roles of clock gene Bmal1 in affective regulation by cholinergic neuronPrincipal Investigator
- Principal Investigator
  
  Otsuka Tsuyoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Gifu University
Controlling mechanisms of the serotonergic system by a clock gene Rev-erb alpha relating to bipolar disorderPrincipal Investigator
- Principal Investigator
  
  Otsuka Tsuyoshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Wakayama Medical University
The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice
- Principal Investigator
  
  Kohsaka Akira
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology(including physical medicine and nutritional physiology)
- Research Institution
  Wakayama Medical University

All 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Adverse Effects of Circadian Disorganization on Mood and Molecular Rhythms in the Prefrontal Cortex of Mice2020
- Author(s)
  Otsuka. T, Le. HT, Kohsaka. A, Sato. F, Ihara. H, Nakao. T, Maeda. M
- Journal Title
  
  Neuroscience
  
  Volume: 432 Pages: 44-54
- DOI
  10.1016/j.neuroscience.2020.02.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15524, KAKENHI-PROJECT-19K08710, KAKENHI-PROJECT-20K11651
[Journal Article] Smad3 Suppresses Epithelial Cell Migration and Proliferation via the Clock Gene Dec1, Which Negatively Regulates the Expression of Clock Genes Dec2 and Per12019
- Author(s)
  Fuyuki Sato, Tsuyoshi Otsuka, Akira Kohsaka, Hue Thi Le, Ujjal K. Bhawal, Yasuteru Muragaki
- Journal Title
  
  American Journal of Pathology
  
  Volume: 189(4) Issue: 4 Pages: 773-783
- DOI
  10.1016/j.ajpath.2019.01.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09921, KAKENHI-PROJECT-18K09922, KAKENHI-PROJECT-16K09624, KAKENHI-PROJECT-19K08710, KAKENHI-PROJECT-18K15524
[Journal Article] Impact of heart-specific disruption of the circadian clock on systemic glucose metabolism in mice2017
- Author(s)
  Nakao T, Kohsaka A, Otsuka T, Thein ZL, Le HT, Waki H, Gouraud SS, Ihara H, Nakanishi M, Sato F, Muragaki Y, Maeda M.
- Journal Title
  
  Chronobiol Int
  
  Volume: in press Issue: 4 Pages: 499-510
- DOI
  10.1080/07420528.2017.1415922
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09624, KAKENHI-PROJECT-16K12728, KAKENHI-PROJECT-15K08430, KAKENHI-PROJECT-16K19781
[Presentation] β-カロテンの給与が肉用繁殖雌牛の非妊娠期における卵巣機能および発情に及ぼす影響2020
- Author(s)
  三ツ石裕貴、夏堀恵利、中辻幸信、大塚剛司、八代田真人
- Organizer
  2020東海畜産学会学会
- Data Source
  KAKENHI-PROJECT-18K15524
[Presentation] 去勢による熱産生関連遺伝子Ucp1の発現異常と生体リズム変化の関連性2020
- Author(s)
  大西裕貴、鈴木茉央、丸澤茉実、大塚剛司
- Organizer
  日本畜産学会第128回大会
- Data Source
  KAKENHI-PROJECT-18K15524
[Presentation] Castration alters the circadian clock and the expression of Ucp1 in subcutaneous white adipose tissue of mice2020
- Author(s)
  大西裕貴、鈴木茉央、丸澤茉実、大塚剛司
- Organizer
  第27回日本時間生物学会
- Data Source
  KAKENHI-PROJECT-18K15524
[Presentation] Constant light exposure leads to the down-regulation of clock genes expression with circadian clock disorganization in pregnant beef cows2020
- Author(s)
  T. Otsuka, H. Mitsuishi, H. Onishi, M. Yayota
- Organizer
  第97回日本生理学会
- Data Source
  KAKENHI-PROJECT-18K15524
[Presentation] The circadian rhythm of plasma progesterone concentration under constant lights in Japanese black cows2020
- Author(s)
  T. Otsuka, H. Mitsuishi, H. Onishi, M. Yayota
- Organizer
  第27回日本時間生物学会
- Data Source
  KAKENHI-PROJECT-18K15524
[Presentation] 去勢に伴うテストステロン合成阻害は脂肪細胞の体内時計とUcp1発現に影響しない2020
- Author(s)
  大西裕貴、鈴木茉央、丸澤茉実、大塚剛司
- Organizer
  2020東海畜産学会学会
- Data Source
  KAKENHI-PROJECT-18K15524
[Presentation] 分娩前後のβ-カロテンの給与が分娩後の黒毛和種繁殖牛の卵巣機能に及ぼす影響2020
- Author(s)
  三ツ石裕貴、大塚剛司、中辻幸信、八代田真人
- Organizer
  日本畜産学会第128回大会
- Data Source
  KAKENHI-PROJECT-18K15524
[Presentation] Smad3 suppress epithelial cells migration and proliferation via the clock gene Dec1, which negatively regulates the clock genes Dec2 and Per12019
- Author(s)
  F. Sato, T. Otsuka, A. Kohsaka, H. T. Le, B. K. Bhawal, Y. Muragaki
- Organizer
  第26回日本時間生物学会
- Data Source
  KAKENHI-PROJECT-18K15524
[Presentation] 生体リズムの乱れは情動行動および前頭前皮質の時計遺伝子機能に影響する2019
- Author(s)
  向阪　彰、大塚剛司、レ　ティ　フォエ、中田正範
- Organizer
  第86回和歌山医学会総会
- Data Source
  KAKENHI-PROJECT-18K15524
[Presentation] Evaluation of circadian clock using follicle cells in Japanese black cattle.2019
- Author(s)
  T. Otsuka, H. Mitsuishi, H. Onishi, M. Yayota
- Organizer
  第26回日本時間生物学会
- Data Source
  KAKENHI-PROJECT-18K15524
[Presentation] Evaluation of circadian clock using follicle cells in Japanese black cattle2019
- Author(s)
  T. Otsuka, H. Mitsuishi, H. Onishi, M. Yayota
- Organizer
  第26回日本時間生物学会
- Data Source
  KAKENHI-PROJECT-18K15524
[Presentation] 黒毛和種繁殖牛は妊娠期特有の時計遺伝子発現リズムを示す2019
- Author(s)
  大塚剛司、三ツ石裕貴、大西裕貴、八代田真人
- Organizer
  2019東海畜産学会学会
- Data Source
  KAKENHI-PROJECT-18K15524
[Presentation] Effect of Rev-erbα deficiency on the serotonergic system and mood regulation in mice2018
- Author(s)
  Otsuka T, Kohsaka A, Le T H, Nakao T, Thein L Z, Maeda M
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K19781
[Presentation] Role of the circadian transcriptional repressor, REV-ERBα in the regulation of food intake under stress.2018
- Author(s)
  Thein L Z, Kohsaka A, Otsuka T, Tsujimoto T, Le T H, Nakao T, Maeda M
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K19781
[Presentation] The Nuclear Receptor REV-ERBα Alters Mood and Neurotransmission in the Prefrontal Cortex.2017
- Author(s)
  T. Otsuka, A. Kohsaka, H. T. Le, T. Nakao, Z. L. Thein, M. Maeda
- Organizer
  Experimental Biology
- Place of Presentation
  Chicago, USA
- Year and Date
  2017-04-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19781
[Presentation] Alteration in mood and serotonergic pathways in Rev-erbα deficient mice2017
- Author(s)
  Otsuka T, Kohsaka A, Le T H, Nakao T, Thein L Z, Maeda M
- Organizer
  Consortium of Biological Sciences
- Data Source
  KAKENHI-PROJECT-16K19781
[Presentation] Transcriptome analysis reveals dysregulation of the prefrontal neuronal networks of Rev-erbα deficient mice.2017
- Author(s)
  T. Otsuka, A. Kohsaka, H. T. Le, T. Nakao, Z. L. Thein, M. Maeda
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  アクトシティ浜松
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K19781
[Presentation] Heart-Specific Disruption of Bmal1 Leads to Hepatic Insulin Resistance in Mice.2017
- Author(s)
  Nakao T, Kohsaka A, Le T H, Otsuka T, Thein L Z, Sato F, Ihara H, Maeda M
- Organizer
  Experimental Biology
- Data Source
  KAKENHI-PROJECT-16K19781
[Presentation] 心臓特異的な時計遺伝子Bmal1の欠損は肝臓のインスリン抵抗性を惹起する2017
- Author(s)
  中尾友美、向阪　彰、レ　ティ　フォエ、大塚剛司、テン　ソーレン、佐藤冬樹、井原勇人、前田正信
- Organizer
  第90回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K19781
[Presentation] ストレス下の摂食調節における時計遺伝子Rev-erbαの役割2017
- Author(s)
  大塚剛司、向阪　彰、辻本敬之、テン　ソーレン、中尾友美、レ　ティ　フォエ、前田正信
- Organizer
  第110回近畿生理学談話会
- Data Source
  KAKENHI-PROJECT-16K19781
[Presentation] Circadian desynchronization alters mood and the regulation of genes associated with neuronal activity in the prefrontal cortex of mice.2017
- Author(s)
  H. T. Le, T. Otsuka, A. Kohsaka, T. Nakao, Z. L. Thein, M. Maeda
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  アクトシティ浜松
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K19781
[Presentation] Rev-erbα deficiency is associated with mixed affective behaviors in mice.2016
- Author(s)
  T. Otsuka, A. Kohsaka, H. T. Le, M. Maeda
- Organizer
  Society for Research on Biological Rhythms
- Place of Presentation
  Palm harbor, Florida, USA
- Year and Date
  2016-05-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19781
[Presentation] Transcriptome analysis reveals dysregulation of genes associated with neuronal development and mood regulation in the prefrontal cortex of Rev-erbα deficient mice2016
- Author(s)
  大塚剛司、向阪彰、レ　ティ　フォエ、中尾友美、テン　ソーレン、前田正信
- Organizer
  第23回日本時間生物学会
- Place of Presentation
  名古屋大学
- Year and Date
  2016-11-12
- Data Source
  KAKENHI-PROJECT-16K19781
[Presentation] Expression profile of mood-related genes in the prefrontal cortex of Rev-erbα deficient mice.2016
- Author(s)
  T. Otsuka, A. Kohsaka, H. T. Le, M. Maeda
- Organizer
  17th Asian Australasian Animal Production
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2016-08-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19781
[Presentation] Heart-specific disruption of Bmal1 leads to age-dependent hyperglycemia in mice2016
- Author(s)
  Tomomi Nakao, Akira Kohsaka, Tsuyoshi Otsuka, Hue Thi Le, Masanobu Maeda
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-25460316
[Presentation] Effect of the disrupted behavioral rhythm on mood and rhythmic expression of genes in the prefrontal cortex of mice2016
- Author(s)
  H. T. Le, T. Otsuka, A. Kohsaka, T. Nakao, Z. L. Thein, M. Maeda
- Organizer
  第109回近畿生理学談話会
- Place of Presentation
  大阪市立大学
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-16K19781
[Presentation] トランスクリプトーム解析を用いたRev-erbαノックアウトマウスの情動行動異常の原因探索2016
- Author(s)
  大塚剛司, 向阪彰, レ　ティ　フォエ, 中尾友美, テン　ソーレン, 前田正信
- Organizer
  第109回近畿生理学談話会
- Place of Presentation
  大阪市立大学
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-16K19781
[Presentation] マウス心筋の体内時計異常はインスリン抵抗性を引き起こす2015
- Author(s)
  向阪　彰、中尾友美、大塚剛司、レ　ティ　フォエ、前田正信
- Organizer
  第51回高血圧関連疾患モデル学会学術総会
- Place of Presentation
  千里ライフサイエンスセンター
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-25460316
[Presentation] Effects of heart-specific disruption of the circadian clock on systemic glucose metabolism in mice2015
- Author(s)
  Akira Kohsaka, Tomomi Nakao, Tsuyoshi Otsuka, Hue Thi Le, Masanobu Maeda
- Organizer
  8th FAOPS Congress
- Place of Presentation
  Bangkok
- Year and Date
  2015-11-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460316
[Presentation] 心臓の分子時計異常が与える全身の糖代謝調節への影響2015
- Author(s)
  中尾友美、向阪　彰、大塚剛司、レ　ティ　フォエ、前田正信
- Organizer
  第108回近畿生理学談話会
- Place of Presentation
  近畿大学東大阪キャンパス　39号館
- Year and Date
  2015-10-24
- Data Source
  KAKENHI-PROJECT-25460316

1. Kohsaka Akira (00458051)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. Waki Hidefumi (50274957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Gouraud Sabine (30453179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SATO Fuyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. バワールウジャール

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 村垣泰光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OTSUKA Tsuyoshi 大塚 剛司

Otsuka Tsuyoshi 大塚 剛司

Research Projects

Research Products

Co-Researchers

ヴィーガンモデル動物を用いた脳腸相関に基づく精神疾患発症機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The roles of clock gene Bmal1 in affective regulation by cholinergic neuronPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Controlling mechanisms of the serotonergic system by a clock gene Rev-erb alpha relating to bipolar disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Adverse Effects of Circadian Disorganization on Mood and Molecular Rhythms in the Prefrontal Cortex of Mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Smad3 Suppresses Epithelial Cell Migration and Proliferation via the Clock Gene Dec1, Which Negatively Regulates the Expression of Clock Genes Dec2 and Per12019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of heart-specific disruption of the circadian clock on systemic glucose metabolism in mice2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] β-カロテンの給与が肉用繁殖雌牛の非妊娠期における卵巣機能および発情に及ぼす影響2020

Author(s)

Organizer

Data Source

[Presentation] 去勢による熱産生関連遺伝子Ucp1の発現異常と生体リズム変化の関連性2020

Author(s)

Organizer

Data Source

[Presentation] Castration alters the circadian clock and the expression of Ucp1 in subcutaneous white adipose tissue of mice2020

Author(s)

Organizer

Data Source

[Presentation] Constant light exposure leads to the down-regulation of clock genes expression with circadian clock disorganization in pregnant beef cows2020

Author(s)

Organizer

Data Source

[Presentation] The circadian rhythm of plasma progesterone concentration under constant lights in Japanese black cows2020

Author(s)

Organizer

Data Source

[Presentation] 去勢に伴うテストステロン合成阻害は脂肪細胞の体内時計とUcp1発現に影響しない2020

Author(s)

Organizer

Data Source

[Presentation] 分娩前後のβ-カロテンの給与が分娩後の黒毛和種繁殖牛の卵巣機能に及ぼす影響2020

Author(s)

Organizer

Data Source

[Presentation] Smad3 suppress epithelial cells migration and proliferation via the clock gene Dec1, which negatively regulates the clock genes Dec2 and Per12019

Author(s)

Organizer

Data Source

[Presentation] 生体リズムの乱れは情動行動および前頭前皮質の時計遺伝子機能に影響する2019

Author(s)

Organizer

Data Source

OTSUKA Tsuyoshi 大塚剛司

Otsuka Tsuyoshi 大塚剛司