ICHIYAMA KENJI 市山健司

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Ichiyama Kenji 市山健司

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Researcher Number	60777960
Other IDs	https://orcid.org/0000-0002-3340-9799
Affiliation (Current)	2026: 大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤)
Affiliation (based on the past Project Information) *help	2020 – 2025: 大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤) 2016 – 2019: 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤)
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Immunology Except Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields / Biological Sciences
Keywords	Principal Investigator 制御性T細胞 / 自己免疫疾患 / Foxp3 / Ikzf1 / 長鎖非翻訳RNA / Ikzf1変異 / ミスセンス突然変異 / 転写因子複合体 / エピジェネティクス / CRISPRi … More Except Principal Investigator … More 制御性T細胞 / T細胞分化 / ゲノム解析 / 自己免疫病 / 免疫制御 / 免疫自己寛容 / 発生・分化 / 発現制御 / シグナル伝達 / 免疫学 / エピジェネティクス / Foxp3 / 自己免疫疾患 / 自己免疫寛容 Less

Study on the development and function of regulatory T cells and their application to the treatment of immunological diseases
- Principal Investigator
  
  坂口志文
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  The University of Osaka
Elucidation of the mechanism of Treg dysfunction by Ikzf1 mutation and development of a new therapy for autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  市山健司
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Osaka University
Fundamental research for the development of new immune response regulation methods targeting Foxp3 binding factor Ikzf1Principal Investigator
- Principal Investigator
  
  Ichiyama Kenji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Osaka University
Identification and elucidation of novel long non-coding RNA involved in complex formation of Satb1.Principal Investigator
- Principal Investigator
  
  Ichiyama Kenji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Osaka University
The role of long non-coding RNA in the development and suppressive function of regulatory T cellsPrincipal Investigator
- Principal Investigator
  
  Ichiyama Kenji
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Study of the function and development of regulatory T cells
- Principal Investigator
  
  Shimon Sakaguchi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University

All 2025 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book Patent

[Book] 周産期医学2017
- Author(s)
  市山健司、坂口志文
- Total Pages
  6
- Publisher
  東京医学社
- Data Source
  KAKENHI-PROJECT-16H06947
[Journal Article] KLF2 expression in IgG plasma cells at their induction site regulates the migration program.2025
- Author(s)
  Ise W, et al.
- Journal Title
  
  J Exp Med
  
  Volume: 222 Issue: 5
- DOI
  10.1084/jem.20241019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H00450, KAKENHI-PROJECT-24H00610, KAKENHI-PROJECT-23K19467, KAKENHI-PROJECT-24K02295, KAKENHI-PROJECT-22K21354
[Journal Article] Genome-wide CRISPR screen in human T cells reveals regulators of FOXP32025
- Author(s)
  Chen Kelvin Y.、Kibayashi Tatsuya、Giguelay Ambre、Hata Mayu、Nakajima Shunsuke、Mikami Norihisa、Takeshima Yusuke、Ichiyama Kenji、Omiya Ryusuke、Ludwig Leif S.、Hattori Kunihiro、Sakaguchi Shimon
- Journal Title
  
  Nature
  
  Volume: online Issue: 8066 Pages: 191-200
- DOI
  10.1038/s41586-025-08795-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24H00610, KAKENHI-PROJECT-23K14545, KAKENHI-PROJECT-22K21354
[Journal Article] Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity2024
- Author(s)
  Ichiyama Kenji、Long Jia、Kobayashi Yusuke、Horita Yuji、Kinoshita Takeshi、Nakamura Yamami、Kominami Chizuko、Georgopoulos Katia、Sakaguchi Shimon
- Journal Title
  
  Immunity
  
  Volume: 57 Issue: 9 Pages: 2043-2060
- DOI
  10.1016/j.immuni.2024.07.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24H00610, KAKENHI-PROJECT-24K02295, KAKENHI-PROJECT-22K21354
[Journal Article] Ikzf1 association with Foxp3 for Foxp3-dependent gene repression in Treg cells: induction of autoimmunity and tumor immunity by disrupting the association2023
- Author(s)
  Kenji Ichiyama, Jia Long, Yusuke Kobayashi, Yuji Horita, Takeshi Kinoshita, Yamami Nakamura, Chizuko Kominami, Katia Georgopoulos, Shimon Sakaguchi
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2023.08.12.553084
- Open Access
- Data Source
  KAKENHI-PROJECT-21H02748
[Journal Article] Regulatory T Cells and Human Disease2020
- Author(s)
  Sakaguchi Shimon、Mikami Norihisa、Wing James B.、Tanaka Atsushi、Ichiyama Kenji、Ohkura Naganari
- Journal Title
  
  Annual Review of Immunology
  
  Volume: 38 Issue: 1 Pages: 541-566
- DOI
  10.1146/annurev-immunol-042718-041717
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07175, KAKENHI-PROJECT-18K07177, KAKENHI-PROJECT-16H06295
[Journal Article] The role of miR-183 cluster in immunity2019
- Author(s)
  Ichiyama Kenji、Dong Chen
- Journal Title
  
  Cancer Letters
  
  Volume: 443 Pages: 108-114
- DOI
  10.1016/j.canlet.2018.11.035
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07177
[Journal Article] Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-32018
- Author(s)
  Tanaka Kentaro、Martinez Gustavo J.、Yan Xiaowei、Long Weiwen、Ichiyama Kenji、Chi Xinxin、Kim Byung-Seok、Reynolds Joseph M.、Chung Yeonseok、Tanaka Shinya、Liao Lan、Nakanishi Yoichi、Yoshimura Akihiko、Zheng Pan、Wang Xiaohu、Tian Qiang、Xu Jianming、O’Malley Bert W.、Dong Chen
- Journal Title
  
  Cell Reports
  
  Volume: 23 Issue: 8 Pages: 2318-2329
- DOI
  10.1016/j.celrep.2018.04.088
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07177
[Journal Article] Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity.2017
- Author(s)
  Kim BS, Lu H, Ichiyama K, Chen X, Zhang YB, Mistry NA, Tanaka K, Lee YH, Nurieva R, Zhang L, Yang X, Chung Y, Jin W, Chang SH, Dong C.
- Journal Title
  
  Cell Reports
  
  Volume: 21 Issue: 1 Pages: 195-207
- DOI
  10.1016/j.celrep.2017.09.021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06947
[Patent] 腫瘍の予防および／または治療剤2023
- Inventor(s)
  市山健司、坂口志文、堀田裕司、木下武士
- Industrial Property Rights Holder
  市山健司、坂口志文、堀田裕司、木下武士
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-21H02748
[Presentation] Foxp3依存的遺伝子発現制御におけるFoxp3-Ikzf1相互作用の役割：相互作用阻害による自己免疫と腫瘍免疫の誘導2024
- Author(s)
  市山健司
- Organizer
  第33回 Kyoto T cell Conference (KTCC)
- Data Source
  KAKENHI-PROJECT-24K02295
[Presentation] Ikzf1 association with Foxp3 for Foxp3-dependent gene repression in Treg cells: disruption of the association causes autoimmunity.2024
- Author(s)
  Kenji Ichiyama
- Organizer
  12th Annual Meeting of the International Cytokine & Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K02295
[Presentation] Foxp3は転写因子Ikzf1との相互作用を介して制御性T細胞の機能安定性を制御する2024
- Author(s)
  市山健司
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21H02748
[Presentation] Ikzf1 association with Foxp3 for Foxp3-dependent gene repression in Treg cells: induction of autoimmunity by disrupting the association2024
- Author(s)
  Kenji Ichiyama
- Organizer
  Keystone Symposia, Systemic Autoimmune and Autoinflammatory Diseases (B2)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02748
[Presentation] Exon 5 of Ikzf1 is required for Foxp3-dependent gene suppression to maintain the homeostasis of regulatory T cells.2022
- Author(s)
  Kenji Ichiyama
- Organizer
  The 51st Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-21H02748
[Presentation] SRC2 and SRC3 cooperatively regulate Th17 cell development.2021
- Author(s)
  市山健司
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02748
[Presentation] Epigenetic regulation of pathogenic T helper 17 cell differentiation by steroid receptor coactivators.2019
- Author(s)
  Kenji Ichiyama
- Organizer
  The 48th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-18K07177
[Presentation] ステロイド受容体活性化補助因子SRC2およびSRC3はエピジェネティックな活性化制御を介してTh17分化を促進する2019
- Author(s)
  Ichiyama Kenji
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K07177
[Presentation] Identification and functional elucidation of novel regulators in the development of IL-17-producing helper T cells2017
- Author(s)
  市山健司
- Organizer
  第４６回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16H06947

1. Shimon Sakaguchi (30280770)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 三上統久 (20710388)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. ウィングジェイムス (00648694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Chen KelvinYigene (00898851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 竹島雄介 (70893288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

ICHIYAMA KENJI 市山 健司

Ichiyama Kenji 市山 健司

Research Projects

Research Products

Co-Researchers

Study on the development and function of regulatory T cells and their application to the treatment of immunological diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of Treg dysfunction by Ikzf1 mutation and development of a new therapy for autoimmune diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fundamental research for the development of new immune response regulation methods targeting Foxp3 binding factor Ikzf1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification and elucidation of novel long non-coding RNA involved in complex formation of Satb1.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of long non-coding RNA in the development and suppressive function of regulatory T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of the function and development of regulatory T cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 周産期医学2017

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] KLF2 expression in IgG plasma cells at their induction site regulates the migration program.2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-wide CRISPR screen in human T cells reveals regulators of FOXP32025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ikzf1 association with Foxp3 for Foxp3-dependent gene repression in Treg cells: induction of autoimmunity and tumor immunity by disrupting the association2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulatory T Cells and Human Disease2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The role of miR-183 cluster in immunity2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-32018

Author(s)

Journal Title

DOI

ICHIYAMA KENJI 市山健司

Ichiyama Kenji 市山健司

[Presentation] ステロイド受容体活性化補助因子SRC2およびSRC3はエピジェネティックな活性化制御を介してTh17分化を促進する2019