NAGANUMA TATSURO 永沼達郎

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Naganuma Tatsuro 永沼達郎

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Researcher Number	60779619
Other IDs	https://orcid.org/0000-0002-8653-5553
Affiliation (Current)	2026: 北海道大学, 薬学研究院, 講師
Affiliation (based on the past Project Information) *help	2024 – 2025: 北海道大学, 薬学研究院, 講師 2022 – 2023: 北海道大学, 薬学研究院, 助教 2017 – 2021: 慶應義塾大学, 薬学部(芝共立), 助教
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 53050:Dermatology-related / Biological pharmacy Except Principal Investigator Transformative Research Areas, Section (III)
Keywords	Principal Investigator 脂質 / セラミド / 皮膚 / アトピー性皮膚炎 / リピドミクス / 皮膚炎 / 脂質代謝 / 質量分析 / α酸化 / 2位水酸化脂肪酸 … More / 多価不飽和脂肪酸 / スフィンゴ脂質 / 精子 / 乾癬 / LC-MS/MS / メタボローム / 脂肪酸 / メタボローム解析 … More Except Principal Investigator オートファジー / リソソーム / 寿命 / 脂質 / ポストリソソーム / リピドミクス / プロテオミクス Less

精子の特殊なスフィンゴ脂質の代謝機構と雄性生殖機能の制御Principal Investigator
- Principal Investigator
  
  永沼達郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Hokkaido University
Skin lipid diversity and its metabolic regulation for maintenance of skin homeostasisPrincipal Investigator
- Principal Investigator
  
  Tatsuro Naganuma
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Hokkaido University
Support for the creation of the post-lysosomal biology research area.
- Principal Investigator
  
  Nakamura Shuhei
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Nara Medical University
  Osaka University
Analysis of lipid factors driving post-lysosomal signaling.
- Principal Investigator
  
  Nishimura Taki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
Comprehensive lipidomics of skin lipid profiles in the development of dermatitisPrincipal Investigator
- Principal Investigator
  
  Naganuma Tatsuro
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Keio University
Global understanding of the lipid metabolic network involved in skin homeostasisPrincipal Investigator
- Principal Investigator
  
  Naganuma Tatsuro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Keio University

All 2025 2024 2023 2022 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Celecoxib Prevents Smoke-induced Lung Carcinogenesis via Suppression of COX-2/PGE2 Signaling in Mice.2025
- Author(s)
  Sakurai K, Chubachi S, Miyata J, Hamamoto J, Naganuma T, Shimada T, Otake S, Nakayama S, Irie H, Tsutsumi A, Kameyama N, Ahmed E Hegab, Shimoda M, Terai H, Yasuda H, Kanai Y, Arita M and Fukunaga K.
- Journal Title
  
  Front Immunol
  
  Volume: 16 Pages: 1557790-1557790
- DOI
  10.3389/fimmu.2025.1557790
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06583, KAKENHI-PROJECT-23K24116
[Journal Article] Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine-ceramides2023
- Author(s)
  Ota Ai, Morita Hiroya, Naganuma Tatsuro, Miyamoto Masatoshi, Jojima Keisuke, Nojiri Koki, Matsuda Junko, Kihara Akio
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 10 Issue: 4 Pages: 104603-104603
- DOI
  10.1016/j.jbc.2023.104603
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06583, KAKENHI-PROJECT-22H04986, KAKENHI-PROJECT-23K08792
[Journal Article] Role of 2-hydroxy acyl-CoA lyase HACL2 in odd-chain fatty acid production via α-oxidation in vivo2023
- Author(s)
  Mori Keisuke、Naganuma Tatsuro、Kihara Akio
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 34 Issue: 9
- DOI
  10.1091/mbc.e23-02-0042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06583, KAKENHI-PROJECT-22H04986
[Journal Article] Dysregulated ceramide metabolism in mouse progressive dermatitis resulting from constitutive activation of Jak12023
- Author(s)
  Iino Yudai, Naganuma Tatsuro, Arita Makoto
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 64 Issue: 2 Pages: 100329-100329
- DOI
  10.1016/j.jlr.2023.100329
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06583, KAKENHI-PROJECT-20H00495
[Journal Article] Microbiota-Independent Spontaneous Dermatitis Associated with Increased Sebaceous Lipid Production in Tmem79-Deficient Mice2022
- Author(s)
  Morimoto Ari, Fukuda Keitaro, Ito Yoshihiro, Tahara Umi, Sasaki Takashi, Shiohama Aiko, Kawasaki Hiroshi, Kawakami Eiryo, Naganuma Tatsuro, Arita Makoto, Sasaki Hiroyuki, Koseki Haruhiko, Matsui Takeshi, Amagai Masayuki
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 142 Issue: 11 Pages: 2864-2872.e6
- DOI
  10.1016/j.jid.2022.06.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06583, KAKENHI-PROJECT-22H04994
[Journal Article] Polyunsaturated Fatty Acid-Derived Lipid Mediators That Regulate Epithelial Homeostasis2022
- Author(s)
  Naganuma Tatsuro, Fujinami Nodoka, Arita Makoto
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 8 Pages: 998-1007
- DOI
  10.1248/bpb.b22-00252
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-08-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06583, KAKENHI-PROJECT-20H00495
[Journal Article] Homeostatic Function of Dermokine in the Skin Barrier and Inflammation.2020
- Author(s)
  Akira Utsunomiya, Takenao Chino, Natsuko Utsunomiya, Vu Huy Luong, Atsushi Tokuriki, Tatsuro Naganuma, Makoto Arita, Kiyoshi Higashi, Koichi Saito, Noriyuki Suzuki, Ayako Ohara, Manabu Sugai, Koji Sugawara, Daisuke Tsuruta, Noritaka Oyama, Minoru Hasegawa
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 140 Issue: 4 Pages: 838-849
- DOI
  10.1016/j.jid.2019.09.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17816, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05898, KAKENHI-PROJECT-18K19423, KAKENHI-PROJECT-18K16052
[Journal Article] Catalytic residues, substrate specificity, and role in carbon starvation of the 2-hydroxy FA dioxygenase Mpo1 in yeast2020
- Author(s)
  Mori Keisuke, Obara Takashi, Seki Naoya, Miyamoto Masatoshi, Naganuma Tatsuro, Kitamura Takuya, Kihara Akio
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 61 Issue: 7 Pages: 1104-1114
- DOI
  10.1194/jlr.ra120000803
- NAID
  120007126048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03976, KAKENHI-PROJECT-19K17816
[Journal Article] Decreased Skin Barrier Lipid Acylceramide and Differentiation-Dependent Gene Expression in Ichthyosis Gene Nipal4-Knockout Mice.2018
- Author(s)
  Honda Y, Kitamura T, Naganuma T, Abe T, Ohno Y, Sassa T, Kihara A
- Journal Title
  
  J. Invest. Dermatol.
  
  Volume: 138 Issue: 4 Pages: 741-749
- DOI
  10.1016/j.jid.2017.11.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08220, KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-15H05589, KAKENHI-PROJECT-17K15452
[Journal Article] 脂肪酸クオリティと炎症・アレルギーの制御2017
- Author(s)
  永沼達郎、有田誠
- Journal Title
  
  炎症と免疫
  
  Volume: 25 Pages: 265-270
- Data Source
  KAKENHI-PROJECT-17K15452
[Presentation] 脂肪族アシルCoA還元酵素FAR1のセミノリピド合成と精子形成における役割2024
- Author(s)
  玉澤彩乃, 永沼達郎, 大塚賢人, 佐々貴之, 木原章雄
- Organizer
  第97回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K06583
[Presentation] 雄性生殖機能における2-水酸化脂肪酸α酸化の役割2024
- Author(s)
  永沼達郎, 木原章雄
- Organizer
  第66回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-22K06583
[Presentation] 酸性セラミダーゼ ASAH1 による表皮セラミドの恒常性維持2024
- Author(s)
  信本和奏, 永沼達郎, 木原章雄
- Organizer
  第61回日本生化学会北海道支部例会
- Data Source
  KAKENHI-PROJECT-22K06583
[Presentation] 2-水酸化脂肪酸のα酸化不全は雄性不妊を引き起こす2024
- Author(s)
  永沼達郎, 木原章雄
- Organizer
  第17回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-22K06583
[Presentation] 皮膚炎発症過程における脂質代謝変化の包括的リピドミクス解析2023
- Author(s)
  永沼達郎, 飯野雄大, 有田誠
- Organizer
  第35回バイオメディカル分析科学シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06583
[Presentation] アトピー性皮膚炎の病態形成におけるセラミド代謝異常2022
- Author(s)
  飯野雄大、永沼達郎、有田誠
- Organizer
  日本脂質生化学会2022
- Data Source
  KAKENHI-PROJECT-22K06583
[Presentation] 皮膚炎の進行に伴う脂肪酸代謝変動とその役割の包括的解析2022
- Author(s)
  藤波和夏、磯部洋輔、永沼達郎、有田誠
- Organizer
  第21回次世代を担う若手のためのファーマ・バイオフォーラム2022
- Data Source
  KAKENHI-PROJECT-22K06583
[Presentation] Aberrant sebaceous lipid metabolism in the early stage of spontaneous dermatitis in Tmem79-deficient mice2020
- Author(s)
  Ari Morimoto, Yoshihiro Ito, Takashi Sasaki, Aiko Shiohama, Hiroshi Kawasaki, Ai Hirabayashi, Mayuko Sato, Kiminori Toyooka, Eiryo Kawakami, Tatsuro Naganuma, Makoto Arita, Haruhiko Koseki, Takeshi Matsui, Masayuki Amagai
- Organizer
  日本研究皮膚科学会　第45年次学術大会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17816
[Presentation] 炎症性皮膚疾患の病態形成過程における脂質代謝変動の包括的メタボローム解析2020
- Author(s)
  永沼達郎，飯野雄大，平野愛美，岡村真宜，有田誠
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-19K17816
[Presentation] アレルギー性接触性皮膚炎の病態制御に関わる脂肪酸代謝系の包括的解析2019
- Author(s)
  平野愛美，永沼達郎，有田誠
- Organizer
  第61回脂質生化学会
- Data Source
  KAKENHI-PROJECT-19K17816
[Presentation] ヒト培養ケラチノサイトにおける脂肪酸代謝系の包括的解析2019
- Author(s)
  中野裕介，永沼達郎，有田誠
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K17816
[Presentation] アレルギー性接触皮膚炎の病態形成過程における脂肪酸代謝系の包括的解析2019
- Author(s)
  平野愛美，永沼達郎，有田誠
- Organizer
  第18回次世代を担う若手ファーマ・バイオフォーラム2019
- Data Source
  KAKENHI-PROJECT-19K17816
[Presentation] Untargeted lipidomics revealed dysregulated ceramide metabolism in the initiation phase of atopic dermatitis2019
- Author(s)
  Yudai Iino, Tatsuro Naganuma, Makoto Arita
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15452
[Presentation] Untargeted lipidomics revealed dysregulated ceramide metabolism in the initiation phase of atopic dermatitis2019
- Author(s)
  Yudai Iino, Tatsuro Naganuma, Makoto Arita
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17816
[Presentation] アトピー性皮膚炎マウスにおける脂質代謝異常の網羅的解析2018
- Author(s)
  飯野雄大，永沼達郎，有田誠
- Organizer
  第17回次世代を担う若手ファーマ・バイオフォーラム2018
- Data Source
  KAKENHI-PROJECT-17K15452
[Presentation] アトピー性皮膚炎発症に関わる脂質代謝系の網羅的メタボローム解析2018
- Author(s)
  飯野雄大，永沼達郎，有田誠
- Organizer
  第60回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-17K15452
[Presentation] 皮膚の網羅的リピドミクスと疾患モデルへの適用2018
- Author(s)
  永沼達郎，飯野雄大，有田誠
- Organizer
  第11回セラミド研究会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K15452
[Presentation] Untargeted analysis of skin lipid profiles in the development of dermatitis2018
- Author(s)
  Tatsuro Naganuma, Yudai Iino, Makoto Arita
- Organizer
  2nd Japan-Korea Joint Lipid Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15452
[Presentation] Skin Homeostasis and Lipid Metabolism2017
- Author(s)
  永沼達郎
- Organizer
  University of Strasbourg-RIKEN Workshop on Membrane Lipidology
- Data Source
  KAKENHI-PROJECT-17K15452

1. Nakamura Shuhei (00510611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. Nishimura Taki (70552991)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 藤田尚信 (00506496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 吉川治孝 (60709567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 大場陽介 (90968603)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 木原章雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 佐々貴之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAGANUMA TATSURO 永沼 達郎

Naganuma Tatsuro 永沼 達郎

Research Projects

Research Products

Co-Researchers

精子の特殊なスフィンゴ脂質の代謝機構と雄性生殖機能の制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Skin lipid diversity and its metabolic regulation for maintenance of skin homeostasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Support for the creation of the post-lysosomal biology research area.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of lipid factors driving post-lysosomal signaling.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive lipidomics of skin lipid profiles in the development of dermatitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Global understanding of the lipid metabolic network involved in skin homeostasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Celecoxib Prevents Smoke-induced Lung Carcinogenesis via Suppression of COX-2/PGE2 Signaling in Mice.2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine-ceramides2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of 2-hydroxy acyl-CoA lyase HACL2 in odd-chain fatty acid production via α-oxidation in vivo2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dysregulated ceramide metabolism in mouse progressive dermatitis resulting from constitutive activation of Jak12023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microbiota-Independent Spontaneous Dermatitis Associated with Increased Sebaceous Lipid Production in Tmem79-Deficient Mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polyunsaturated Fatty Acid-Derived Lipid Mediators That Regulate Epithelial Homeostasis2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Homeostatic Function of Dermokine in the Skin Barrier and Inflammation.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Catalytic residues, substrate specificity, and role in carbon starvation of the 2-hydroxy FA dioxygenase Mpo1 in yeast2020

NAGANUMA TATSURO 永沼達郎

Naganuma Tatsuro 永沼達郎