Tsukagoshi Mariko 塚越真梨子

Researcher Number	60781317
Other IDs
Affiliation (Current)	2022: 群馬大学, 大学院医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2018 – 2022: 群馬大学, 大学院医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50010:Tumor biology-related Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator 癌関連線維芽細胞 / 肝癌 / サイトカイン / 癌微小環境 / Conophylline / 薬剤耐性 / 肝細胞癌 / 肝星細胞 / コノフィリン / GPR68 … More Except Principal Investigator … More 肝胆膵がん / 癌関連線維芽細胞 / M2BPGi / 肝胆膵癌 / マウス皮下腫瘍モデル / Galectin 3阻害剤 / サルコペニア / 肝再生 / 肝切除 / 分岐鎖アミノ酸 / 肝筋相関 / PGC1αマウス / 肝再生率 / 肝筋連関 / PGC-1αマウス / 膵癌 / STMN1 / 温熱療法 / 化学療法 / シナジー効果 / 疲弊化CD8T細胞 / 免疫チェックポイント分子 / 腫瘍免疫 / IL-17産生γδ型Ｔ細胞 / 難治癌 Less

STMN1を標的とした化学療法・温熱療法とのシナジーによる膵癌新規治療法の開発
- Principal Investigator
  
  渡辺亮
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
Identification of novel immune check point molecules in exhausted CD8+ T cells
- Principal Investigator
  
  矢島俊樹
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Gunma University
IL-17産生γδ型Ｔ細胞を制御する新規癌免疫療法の創生を目指した基礎的研究
- Principal Investigator
  
  調憲
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Gunma University
Development of new therapeutic methods targeting cytokine regulators in cancer-related fibroblastsPrincipal Investigator
- Principal Investigator
  
  Tsukagoshi Mariko
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Gunma University
Evaluation of the effect of sarcopenia on liver regeneration from the viewpoint between liver and muscle correlation
- Principal Investigator
  
  Araki Kenichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
Development of innovative treatment targeting liver cancer associated fibroblastPrincipal Investigator
- Principal Investigator
  
  Tsukagoshi Mariko
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
New humoral factor facilitates hepato-biliary and pancreatic cancer progression and development of innovative thrapy
- Principal Investigator
  
  Shirabe Ken
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University

All 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Hepatic stellate cell as a Mac-2-binding protein-producing cell in patients with liver fibrosis2021
- Author(s)
  Gantumur D, Harimoto N, Muranushi R, Hoshino K, Batbayar C, Hagiwara K, Yamanaka T, Ishii N, Tsukagoshi M, Igarashi T, Watanabe A, Kubo N, Araki K, Yokobori T, Aishima S, Shirabe K.
- Journal Title
  
  Hepatol Res .
  
  Volume: Online ahead of print.
- DOI
  10.1111/hepr.13648
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02877
[Journal Article] Conophylline Inhibits Hepatocellular Carcinoma by Inhibiting Activated Cancer-associated Fibroblasts Through Suppression of G Protein?coupled Receptor 682021
- Author(s)
  Yamanaka T, Harimoto N, Yokobori T, Muranushi R, Hoshino K, Hagiwara K, Gantumur D, Handa T, Ishii N, Tsukagoshi M, Igarashi T, Watanabe A, Kubo N, Araki K, Umezawa K, Shirabe K.
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: Online ahead of print. Pages: 1019-1028
- DOI
  10.1158/1535-7163.mct-20-0150
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02877, KAKENHI-PROJECT-20K16352
[Journal Article] Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling2020
- Author(s)
  Dolgormaa Gantumur、Harimoto Norifumi、Ishii Norihiro、Yamanaka Takahiro、Hagiwara Kei、Tsukagoshi Mariko、Igarashi Takamichi、Watanabe Akira、Kubo Norio、Araki Kenichiro、Handa Tadashi、Yokobori Takehiko、Oyama Tetsunari、Kuwano Hiroyuki、Shirabe Ken
- Journal Title
  
  Br J Cancer
  
  Volume: 123 Pages: 1145-1153
- DOI
  10.1038/s41416-020-0971-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16199, KAKENHI-PROJECT-18H02877, KAKENHI-PROJECT-18K07665
[Journal Article] Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts2020
- Author(s)
  Yamanaka Takahiro、Harimoto Norifumi、Yokobori Takehiko、Muranushi Ryo、Hoshino Kouki、Hagiwara Kei、Gantumur Dolgormaa、Handa Tadashi、Ishii Norihiro、Tsukagoshi Mariko、Igarashi Takamichi、Tanaka Hiroshi、Watanabe Akira、Kubo Norio、Araki Kenichiro、Shirabe Ken
- Journal Title
  
  Br J Cancer .
  
  Volume: 122 Pages: 986-994
- DOI
  10.1038/s41416-020-0744-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02877, KAKENHI-PROJECT-20K16199
[Journal Article] Preoperative Mac‐2 binding protein glycosylation isomer level predicts postoperative ascites in patients with hepatic resection for hepatocellular carcinoma2019
- Author(s)
  Ishii Norihiro、Harimoto Norifumi、Araki Kenichiro、Muranushi Ryo、Hoshino Kouki、Hagiwara Kei、Gantumur Dolgormaa、Yamanaka Takahiro、Tsukagoshi Mariko、Igarashi Takamichi、Tanaka Hiroshi、Watanabe Akira、Kubo Norio、Shirabe Ken
- Journal Title
  
  Hepatology Research
  
  Volume: 49 Pages: 1398-1405
- DOI
  10.1111/hepr.13412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02877
[Journal Article] High Co-expression of Large Tenascin C Splice Variants in Stromal Tissue and Annexin A2 in Cancer Cell Membranes is Associated with Poor Prognosis in Pancreatic Cancer2019
- Author(s)
  Hagiwara Kei、Harimoto Norifumi、Yokobori Takehiko、Muranushi Ryo、Hoshino Kouki、Gantumur Dorgormaa、Yamanaka Takahiro、Ishii Norihiro、Tsukagoshi Mariko、Igarashi Takamichi、Tanaka Hiroshi、Watanabe Akira、Kubo Norio、Araki Kenichiro、Hosouchi Yasuo、Shirabe Ken
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 27 Pages: 924-930
- DOI
  10.1245/s10434-019-07708-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02877
[Presentation] 抗原特異的 CD8T 細胞の疲弊化誘導における各免疫チェックポイント分子の役割2022
- Author(s)
  村主　遼、矢島俊樹、星野弘毅、山中崇弘、萩原慶、塚越真梨子、石井範洋、渡辺亮、新木健一郎、播本憲史、調　憲
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K19518
[Presentation] 抗 PD-1 抗体耐性メカニズムにおける疲弊化 CD8T 細胞での各免疫チェックポイント分子の役割2022
- Author(s)
  矢島　俊樹、村主遼、星野弘毅、吉川良平、大瀧容一、尾林海、中澤世識、河谷菜津子、矢澤友弘、塚越真梨子、調憲
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K19518
[Presentation] サルコペニアにおける肝切除後肝再生抑制に関する基礎的研究2021
- Author(s)
  萩原慶、播本憲史、新木健一郎、久保憲生、渡辺亮、五十嵐隆通、塚越真梨子、石井範洋、星野弘毅、村主遼、調憲
- Organizer
  第121 回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09163
[Presentation] 抗原特異的CD8陽性T細胞の疲弊化誘導における各免疫チェックポイント分子の役割2021
- Author(s)
  村主　遼、矢島俊樹、星野弘毅、栗山健吾、塚越真梨子、山中崇弘、萩原慶、石井範洋、渡辺亮、新木健一郎、播本憲史、調　憲
- Organizer
  第59回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19518
[Presentation] サルコペニアにおける肝切除後肝再生抑制に関する基礎的研究2021
- Author(s)
  萩原慶、播本憲史、新木健一郎、久保憲生、渡辺亮、五十嵐隆通、塚越真梨子、石井範洋、星野弘毅、村主遼、調憲
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09163
[Presentation] 抗原特異的CD8Ｔ細胞誘導マウス腫瘍モデルを用いた動態解析2021
- Author(s)
  星野　弘毅、矢島俊樹、播本憲史、村主遼、萩原慶、山中崇弘、石井範洋、塚越真梨子、渡辺亮、新木健一郎、調　憲
- Organizer
  第59回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19518
[Presentation] 癌関連線維芽細胞が産生するサイトカインの制御に基づく，肝癌の新たな治療戦略2020
- Author(s)
  山中崇弘、播本憲史、村主遼、星野弘毅、萩原慶、石井範洋、塚越真梨子、五十嵐隆通、渡辺亮、久保憲生、新木健一郎、梅澤一夫、調憲
- Organizer
  第120回日本外科学会
- Data Source
  KAKENHI-PROJECT-18H02877

1. Shirabe Ken (70264025)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
2. Araki Kenichiro (60431706)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
3. 播本憲史 (00419582)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
4. 石井範洋 (00711508)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
5. 久保憲生 (10464744)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
6. 渡辺亮 (60738847)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. 矢島俊樹 (20346852)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
8. 五十嵐隆通 (20648472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 市川聡 (60333621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 横堀武彦 (60420098)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
11. 大瀧容一 (00625402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 中澤世識 (60791978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 桑野博行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsukagoshi Mariko 塚越 真梨子

Research Projects

Research Products

Co-Researchers

STMN1を標的とした化学療法・温熱療法とのシナジーによる膵癌新規治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel immune check point molecules in exhausted CD8+ T cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

IL-17産生γδ型Ｔ細胞を制御する新規癌免疫療法の創生を目指した基礎的研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new therapeutic methods targeting cytokine regulators in cancer-related fibroblastsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of the effect of sarcopenia on liver regeneration from the viewpoint between liver and muscle correlation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of innovative treatment targeting liver cancer associated fibroblastPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New humoral factor facilitates hepato-biliary and pancreatic cancer progression and development of innovative thrapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Hepatic stellate cell as a Mac-2-binding protein-producing cell in patients with liver fibrosis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conophylline Inhibits Hepatocellular Carcinoma by Inhibiting Activated Cancer-associated Fibroblasts Through Suppression of G Protein?coupled Receptor 682021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preoperative Mac‐2 binding protein glycosylation isomer level predicts postoperative ascites in patients with hepatic resection for hepatocellular carcinoma2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High Co-expression of Large Tenascin C Splice Variants in Stromal Tissue and Annexin A2 in Cancer Cell Membranes is Associated with Poor Prognosis in Pancreatic Cancer2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] 抗原特異的 CD8T 細胞の疲弊化誘導における各免疫チェックポイント分子の役 割2022

Author(s)

Organizer

Data Source

Tsukagoshi Mariko 塚越真梨子

[Presentation] 抗原特異的 CD8T 細胞の疲弊化誘導における各免疫チェックポイント分子の役割2022

[Presentation] 抗 PD-1 抗体耐性メカニズムにおける疲弊化 CD8T 細胞での各免疫チェックポイント分子の役割2022

[Presentation] サルコペニアにおける肝切除後肝再生抑制に関する基礎的研究2021

[Presentation] サルコペニアにおける肝切除後肝再生抑制に関する基礎的研究2021

[Presentation] 癌関連線維芽細胞が産生するサイトカインの制御に基づく，肝癌の新たな治療戦略2020