Mori Akio 森聡生

Researcher Number	60782878
Affiliation (Current)	2025: 順天堂大学, 医学部, 非常勤助教
Affiliation (based on the past Project Information) *help	2020 – 2023: 順天堂大学, 医学部, 非常勤助教 2019 – 2020: 順天堂大学, 医学部, 助教 2018: 順天堂大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 43030:Functional biochemistry-related / Basic Section 51030:Pathophysiologic neuroscience-related Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator 疾患修飾治療 / 脂質代謝破綻 / 神経変性疾患 / α-シヌクレイン / パーキンソン病 / 脂質代謝 / エクソソーム / リン脂質 / グルコシルセラミド / GBA … More / エクソサイトーシス / エキソサイトーシス / シナプス機能 / シナプス小胞 / 生体膜 / 凝集体形成 / リポソーム / 神経変性 / PLA2G６ / PLA2G6 / ショウジョウバエ / 異常タンパク質 / 脂質代謝異常 … More Except Principal Investigator α-シヌクレイン / 腸脳連関 / 腸脳関連 / α-シヌクレイン（AS) / 制御性T細胞 / Programmed cell death-1 / パーキンソン病 Less

Lipid alteration and synaptic dysfunctionPrincipal Investigator
- Principal Investigator
  
  森聡生
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Juntendo University
リン脂質代謝異常による神経変性を起こす機序の解明Principal Investigator
- Principal Investigator
  
  森聡生
- Project Period (FY)
  2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Juntendo University
Pathogenesis role of programmed cell death-1 in Parkinson's disease mouse model
- Principal Investigator
  
  Hattori Nobutaka
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Juntendo University
Investigation of lipid metabolism in Parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  Mori Akio
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Juntendo University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] The identified clinical features of Parkinson's disease in homo-, heterozygous and digenic variants of PINK12021
- Author(s)
  Hayashida Arisa、Li Yuanzhe、Yoshino Hiroyo、Daida Kensuke、Ikeda Aya、et al.
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 97 Pages: 3301-3301
- DOI
  10.1016/j.neurobiolaging.2020.06.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-20K07893, KAKENHI-PROJECT-19K17047, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-18K15376, KAKENHI-PROJECT-18H02743, KAKENHI-PROJECT-21H04820
[Journal Article] Nonmercaptalbumin as an oxidative stress marker in Parkinson's and PARK2 disease2020
- Author(s)
  Ueno SI, Hatano T, Okuzumi A, Saiki S, Oji Y, Mori A, Koinuma T, Fujimaki M, Takeshige-Amano H, Kondo A, Yoshikawa N, Nojiri T, Kurano M, Yasukawa K, Yatomi Y, Ikeda H, Hattori N
- Journal Title
  
  Ann Clin Transl Neurol
  
  Volume: 7 Issue: 3 Pages: 307-317
- DOI
  10.1002/acn3.50990
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16928, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-18K15376
[Journal Article] Lipids: Key Players That Modulate -Synuclein Toxicity and Neurodegeneration in Parkinson’s Disease2020
- Author(s)
  Akio Mori, Yuzuru Imai, Nobutaka Hattori
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 9 Pages: 9-9
- DOI
  10.3390/ijms21093301
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15376, KAKENHI-PROJECT-19K22603, KAKENHI-PROJECT-20K21531, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-20H03453
[Journal Article] A metabolic profile of polyamines in parkinson disease: A promising biomarker2019
- Author(s)
  Saiki Shinji、Sasazawa Yukiko、Fujimaki Motoki、Kamagata Koji、Kaga Naoko、Taka Hikari、Li Yuanzhe、Souma Sanae、Hatano Taku、Imamichi Yoko、Furuya Norihiko、Mori Akio、Oji Yutaka、Ueno Shin‐Ichi、Nojiri Shuko、Miura Yoshiki、Ueno Takashi、Funayama Manabu、Aoki Shigeki、Hattori Nobutaka
- Journal Title
  
  Annals of Neurology
  
  Volume: 86 Issue: 2 Pages: 251-263
- DOI
  10.1002/ana.25516
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KT0027, KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-19K11752, KAKENHI-PROJECT-19K22603, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-18H02744, KAKENHI-PROJECT-18K15464
[Journal Article] Metabolomics‐based identification of metabolic alterations in PARK22019
- Author(s)
  Okuzumi Ayami、Hatano Taku、Ueno Shin‐Ichi、Ogawa Takashi、Saiki Shinji、Mori Akio、Koinuma Takahiro、Oji Yutaka、Ishikawa Kei‐Ichi、Fujimaki Motoki、Sato Shigeto、Ramamoorthy Sivapriya、Mohney Robert P.、Hattori Nobutaka
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: 6 Issue: 3 Pages: 525-536
- DOI
  10.1002/acn3.724
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-16K09675, KAKENHI-PROJECT-19K22603
[Journal Article] Parkinson's disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling.2019
- Author(s)
  Mori A, Hatano T, Inoshita T, Shiba-Fukushima K, Koinuma T, Meng H, Kubo SI, Spratt S, Cui C, Yamashita C, Miki Y, Yamamoto K, Hirabayashi T, Murakami M, Takahashi Y, Shindou H, Nonaka T, Hasegawa M, Okuzumi A, Imai Y, Hattori N.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 116(41) Issue: 41 Pages: 20689-20699
- DOI
  10.1073/pnas.1902958116
- NAID
  120007132272
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-18K06978, KAKENHI-PROJECT-19K07042, KAKENHI-PROJECT-19K22603, KAKENHI-PROJECT-18K15376, KAKENHI-PROJECT-19K16928, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05905, KAKENHI-PUBLICLY-18H05025, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-19H03372, KAKENHI-PROJECT-18K15465, KAKENHI-PROJECT-16H02613
[Journal Article] Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy2019
- Author(s)
  Mori Akio、Ishikawa Kei-Ichi、Saiki Shinji、Hatano Taku、Oji Yutaka、Okuzumi Ayami、Fujimaki Motoki、Koinuma Takahiro、Ueno Shin-Ichi、Imamichi Yoko、Hattori Nobutaka
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 9 Pages: e0223113-e0223113
- DOI
  10.1371/journal.pone.0223113
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KT0027, KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-19K22603, KAKENHI-PROJECT-18K15376, KAKENHI-PROJECT-19K16928, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-18H02744, KAKENHI-PROJECT-18K15463
[Presentation] Lipid alteration and Parkinson’s disease2023
- Author(s)
  Akio Mori, Robert Edwards
- Organizer
  ASAP (Aligning Science Across Parkinson’s) Collaborative Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0380
[Presentation] Lipid metabolism alteration in C19orf12 (MPAN) animal model2022
- Author(s)
  Kenta Shiina, Akio Mori, Yuzuru Imai, Hatano Taku, Nobutaka Hattori
- Organizer
  日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20KK0380
[Presentation] 脂質代謝異常とαシヌクレイン凝集Selective vulnerability of alpha-synuclein-related neurodegeneration -beyond proteinopathy and propagation（シンポジウム）2021
- Author(s)
  波田野琢、王子悠、森聡生、服部信孝
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K22603
[Presentation] Alterations in Red Blood Cell phospholipid composition in Parkinson's disease.2021
- Author(s)
  Kenta Shiina, Akio Mori, Yuzuru Imai, Hatano Taku, Nobutaka Hattori
- Organizer
  日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20KK0380
[Presentation] Alterations in Red Blood Cell phospholipid composition in Parkinson's disease.2021
- Author(s)
  椎名健太，森聡生，木村活生，三木寿美，村上誠，今居譲，波田野琢，服部信孝
- Organizer
  日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K15750
[Presentation] Disease Modifying Therapy in PD2020
- Author(s)
  Akio Mori
- Organizer
  Takamatsu International Symposium for PD ＆MD
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15376
[Presentation] Disease Modifying Therapy in PD2020
- Author(s)
  森　聡生
- Organizer
  第19回高松国際パーキンソン病シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K15376
[Presentation] MSAとPSPの血漿バイオマーカー2019
- Author(s)
  森　聡生
- Organizer
  パーキンソン病・運動障害疾患コングレス
- Data Source
  KAKENHI-PROJECT-18K15376
[Presentation] パーキンソン病・PARK2患者におけるバイオマーカーとしての酸化型アルブミン.2019
- Author(s)
  上野真一, 波田野琢, 奥住文美, 斉木臣二, 王子悠, 森聡生, 濃沼崇博, 藤巻基紀, 安川惠子, 矢冨裕, 池田均, 服部信孝.
- Organizer
  第13回パーキンソン病・運動障害学会コングレス
- Data Source
  KAKENHI-PROJECT-19K22603
[Presentation] Synaptic dysfuncion in a Drosophila model of PARK142019
- Author(s)
  T. Hatano, A. Mori, T. Inoshita, K. Fukushima-Shiba, T. Koinuma, C. Yamashita, Y. Imai, N. Hattori
- Organizer
  International Parkinson and Movement disorder society　2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15376
[Presentation] Parkinson's disease-associated mutations of PLA2G6 alters the membrane dynamics and α-synuclein stability2019
- Author(s)
  A. Mori, T. Hatano, T. Inoshita, K. Shiba-Fukushima, T. Koinuma, C. Yamashita, A. Okuzumi, Y. Imai, N. Hattori
- Organizer
  International Parkinson and Movement disorder society　2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15376
[Presentation] リン脂質リモデリング異常はシナプス機能異常と　　α-シヌクレイン凝集を引き起こす2019
- Author(s)
  森　聡生
- Organizer
  第17回神経科学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K15376
[Presentation] Synaptic dysfunction in a Drosophila model of PARK142019
- Author(s)
  Hatano T, Mori A, Inoshita T, Fukushima-Shiba K, Koinuma T, Yamashita C, Imai Y, Hattori N.
- Organizer
  23rd International Congress of Parkinson’s Disease and Movement Disorders. Sep 22-26, Nice, France.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22603
[Presentation] Serum non-mercaptalbumin as a potential biomarker in Parkinson’s disease and related disorders2019
- Author(s)
  Ueno SI, Hatano T, Okuzumi A, Saiki S, Oji Y, Mori A, Koinuma T, Fujimaki M, Takeshige-Amano H, Yasukawa K, Yatomi Y, Ikeda H, Hattori N.
- Organizer
  23rd International Congress of Parkinson’s Disease and Movement Disorders. Sep 22-26, Nice, France.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22603
[Presentation] 脂質改変治療はパーキンソン病の　新たな疾患修飾治療になる2018
- Author(s)
  森　聡生
- Organizer
  神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15376
[Presentation] 抗MOG抗体関連疾患の髄液MBP値は病変の広がりと相関する2018
- Author(s)
  森　聡生
- Organizer
  日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15376
[Presentation] Parkinson's disease-associated iPLA2-VIA regulates the remodeling of phospholipid membrane, which is important for dopaminergic functions and α-Synuclein turnover2018
- Author(s)
  森　聡生
- Organizer
  日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K15376

1. Hattori Nobutaka (80218510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. 佐藤栄人 (00445537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 波田野琢 (60338390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. 上野真一 (40875944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. FUNAYAMA Manabu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. SASAZAWA Yukiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 奥住文美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 斉木臣二

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
9. 石川景一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mori Akio 森 聡生

Research Projects

Research Products

Co-Researchers

Lipid alteration and synaptic dysfunctionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

リン脂質代謝異常による神経変性を起こす機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathogenesis role of programmed cell death-1 in Parkinson's disease mouse model

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of lipid metabolism in Parkinson's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] The identified clinical features of Parkinson's disease in homo-, heterozygous and digenic variants of PINK12021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nonmercaptalbumin as an oxidative stress marker in Parkinson's and PARK2 disease2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lipids: Key Players That Modulate -Synuclein Toxicity and Neurodegeneration in Parkinson’s Disease2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A metabolic profile of polyamines in parkinson disease: A promising biomarker2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metabolomics‐based identification of metabolic alterations in PARK22019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Parkinson's disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Lipid alteration and Parkinson’s disease2023

Author(s)

Organizer

Data Source

[Presentation] Lipid metabolism alteration in C19orf12 (MPAN) animal model2022

Author(s)

Organizer

Data Source

[Presentation] 脂質代謝異常とαシヌクレイン凝集Selective vulnerability of alpha-synuclein-related neurodegeneration -beyond proteinopathy and propagation（シンポジウム）2021

Author(s)

Organizer

Data Source

[Presentation] Alterations in Red Blood Cell phospholipid composition in Parkinson's disease.2021

Author(s)

Organizer

Data Source

Mori Akio 森聡生

[Presentation] リン脂質リモデリング異常はシナプス機能異常と　　α-シヌクレイン凝集を引き起こす2019

[Presentation] 脂質改変治療はパーキンソン病の　新たな疾患修飾治療になる2018