Shimizu Tomohiro 清水智弘

Researcher Number	60784246
Other IDs
Affiliation (Current)	2022: 北海道大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help	2018 – 2022: 北海道大学, 大学病院, 助教 2017: 北海道大学, 医学研究院, 客員研究員
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related Except Principal Investigator Basic Section 56020:Orthopedics-related
Keywords	Principal Investigator 骨脆弱性 / 慢性腎臓病 / 骨質 / ラット動物モデル / 骨質異常 / CKD / ビスフォスフォネート / テリパラチド / 細胞・組織 / 特発性大腿骨頭壊死症 … More / 好中球 / 自然免疫異常 / 多発骨壊死 / 自然免疫 … More Except Principal Investigator 骨粗鬆症 / 破骨細胞 / インターフェロンシグナル / M2マクロファージ / 制御性T細胞 / 遺伝子プロファイル / 抗炎症性マクロファージ / 好中球由来細胞小胞 / 軟骨細胞 / 関節炎 / 炎症収束性貪食細胞由来細胞外小胞 / 骨折 / 慢性炎症 / 免疫異常 Less

Elucidation of innate immune disorders that regulate joint destruction and joint degeneration after fracture
- Principal Investigator
  
  宮崎拓自
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hokkaido University
抗炎症性マクロファージ由来因子と骨関連細胞に着目した新規骨粗鬆症メカニズムの解明
- Principal Investigator
  
  高橋大介
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hokkaido University
炎症収束性貪食細胞由来細胞外小胞による関節炎収束メカニズムの解明
- Principal Investigator
  
  浅野毅
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hokkaido University
特発性大腿骨頭壊死症の発生・圧潰と自然免疫異常の関連Principal Investigator
- Principal Investigator
  
  清水智弘
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hokkaido University
Bone fragility induced by tissue disoreder of mineral crystals and collargen in chronic kidney diseasePrincipal Investigator
- Principal Investigator
  
  Shimizu Tomohiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hokkaido University

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis2021
- Author(s)
  Ebata Taku、Terkawi Mohamad Alaa、Hamasaki Masanari、Matsumae Gen、Onodera Tomohiro、Aly Mahmoud Khamis、Yokota Shunichi、Alhasan Hend、Shimizu Tomohiro、Takahashi Daisuke、Homan Kentaro、Kadoya Ken、Iwasaki Norimasa
- Journal Title
  
  iScience
  
  Volume: 24 Pages: 102643-102643
- DOI
  10.1016/j.isci.2021.102643
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18516, KAKENHI-PROJECT-20K09471
[Journal Article] Cardiotrophin Like Cytokine Factor 1 (CLCF1) alleviates bone loss in osteoporosis mouse models by suppressing osteoclast differentiation through activating interferon signaling and repressing the nuclear factor-κB signaling pathway.2021
- Author(s)
  Shunichi Yokota, Gen Matsumae, Tomohiro Shimizu, Tomoka Hasegawa, Taku Ebata, Daisuke Takahashi, Cai Heguo, Yuan Tian, Hend Alhasan, Masahiko Takahata, Ken Kadoya, Alaa Terkawi, Norimasa Iwasaki
- Journal Title
  
  Bone
  
  Volume: 153 Pages: 116140-116140
- DOI
  10.1016/j.bone.2021.116140
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09425, KAKENHI-PROJECT-21K19585
[Journal Article] Evaluation of whole-body modalities for diagnosis of multifocal osteonecrosis-a pilot study2021
- Author(s)
  Yokota Shunichi、Sakamoto Keita、Shimizu Yukie、Asano Tsuyoshi、Takahashi Daisuke、Kudo Kohsuke、Iwasaki Norimasa、Shimizu Tomohiro
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 23 Pages: 83-83
- DOI
  10.1186/s13075-021-02473-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17984
[Journal Article] Ten years change in post-fracture care for hip fracture patients.2020
- Author(s)
  Shimodan S, Sato D, Takahashi K, Nakamura Y, Hyakkan R, Watanabe T, Hishimura R, Ota M, Shimizu H, Hojo Y, Hasegawa Y, Chubachi T, Yasui K, Tsujimoto T, Tsukuda Y, Asano T, Takahashi D, Takahata M, Iwasaki N, Shimizu T.
- Journal Title
  
  J Bone Miner Metab.
  
  Volume: 38(2) Pages: 222-229
- NAID
  120006980047
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16670
[Journal Article] Blockade of XCL1/Lymphotactin Ameliorates Severity of Periprosthetic Osteolysis Triggered by Polyethylene-Particles2020
- Author(s)
  Tian Yuan、Terkawi Mohamad Alaa、Onodera Tomohiro、Alhasan Hend、Matsumae Gen、Takahashi Daisuke、Hamasaki Masanari、Ebata Taku、Aly Mahmoud Khamis、Kida Hiroaki、Shimizu Tomohiro、Uetsuki Keita、Kadoya Ken、Iwasaki Norimasa
- Journal Title
  
  Front Immunol
  
  Volume: 11 Pages: 1720-1720
- DOI
  10.3389/fimmu.2020.01720
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09425, KAKENHI-PROJECT-20H03558
[Journal Article] Association of Neutrophil Extracellular Traps with the Development of Idiopathic Osteonecrosis of the Femoral Head2020
- Author(s)
  Nonokawa Mayu、Shimizu Tomohiro、Yoshinari Miku、Hashimoto Yamato、Nakamura Yusuke、Takahashi Daisuke、Asano Tsuyoshi、Nishibata Yuka、Masuda Sakiko、Nakazawa Daigo、Tanaka Satoshi、Tomaru Utano、Iwasaki Norimasa、Ishizu Akihiro
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 190 Pages: 2282-2289
- DOI
  10.1016/j.ajpath.2020.07.008
- NAID
  120007168180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21512, KAKENHI-PROJECT-20K17984, KAKENHI-PROJECT-18H02629
[Journal Article] Potential association with early changes in serum calcium level after starting or switching to denosumab combined with eldecalcitol.2019
- Author(s)
  Asano T, Shimizu T, Takahashi D, Ota M, Sato D, Hamano H, Hiratsuka S, Takahata M, Iwasaki N.
- Journal Title
  
  J Bone Miner Metab.
  
  Volume: 37(2) Pages: 351-357
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16670
[Journal Article] Optimal administration frequency and dose of teriparatide for acceleration of biomechanical healing of long-bone fracture in a mouse model2018
- Author(s)
  Ota Masahiro、Takahata Masahiko、Shimizu Tomohiro、Momma Daisuke、Hamano Hiroki、Hiratsuka Shigeto、Amizuka Norio、Hasegawa Tomoka、Iwasaki Norimasa
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: 37 Pages: 256-263
- DOI
  10.1007/s00774-018-0930-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16670
[Journal Article] Potential association with early changes in serum calcium level after starting or switching to denosumab combined with eldecalcitol2018
- Author(s)
  Asano Tsuyoshi、Shimizu Tomohiro、Takahashi Daisuke、Ota Masahiro、Sato Dai、Hamano Hiroki、Hiratsuka Shigeto、Takahata Masahiko、Iwasaki Norimasa
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: 37 Pages: 351-357
- DOI
  10.1007/s00774-018-0928-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16670
[Journal Article] Efficacy and safety of osteoporosis medications in a rat model of late-stage chronic kidney disease accompanied by secondary hyperparathyroidism and hyperphosphatemia2017
- Author(s)
  Ota M, Takahata M, Shimizu T, Kanehira Y, Kimura-Suda H, Kameda Y, Hamano H, Hiratsuka S, Sato D, Iwasaki N.
- Journal Title
  
  Osteoporosis International
  
  Volume: 28 Pages: 1481-1490
- DOI
  10.1007/s00198-016-3861-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16670, KAKENHI-PROJECT-15H02207
[Presentation] Cardiotrophin Like Cytokine Factor 1 (CLCF1) alleviates excessive bone loss and osteoclast differentiation through activating interferon signaling and repressing the nuclear factor-κB signaling pathway.2022
- Author(s)
  Shunichi Yokota, Gen Matsumae, Tomohiro Shimizu, Taku Ebata, Hend Alhasan, Daisuke Takahashi, M Alaa Terkawi, Norimasa Iwasaki
- Organizer
  ORS 2022 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09425
[Presentation] 手術加療を施行した脆弱性骨折における術後骨粗鬆症検査・治療介入率の検証－北海道10年多施設後ろ向きコホート－2018
- Author(s)
  太田昌博, 清水智弘，菱村亮介, 高橋要, 佐藤大, 辻本武尊, 岸本隆史, 林晴久, 宮本守孝, 佃幸憲, 髙橋大介, 高畑雅彦, 岩崎倫政
- Organizer
  第20回日本骨粗鬆症学会
- Data Source
  KAKENHI-PROJECT-17K16670
[Presentation] 新規骨粗鬆症治療薬が骨粗鬆症性骨脆弱性骨折に及ぼす影響の検討：10年2747例の検討2018
- Author(s)
  佐藤大，清水智弘，菱村亮介，高橋要，太田昌博，辻本武尊，佃幸憲，髙橋大介，高畑雅彦，岩崎倫政
- Organizer
  第20回日本骨粗鬆症学会，長崎市，2018年10月26日-28日
- Data Source
  KAKENHI-PROJECT-17K16670

1. 照川アラー (00723074)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 高橋大介 (90528845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 浅野毅 (50722493)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 宮崎拓自 (70908194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HOMAN Kentaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. TAKAHATA Masahiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. テルカウィアラー

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
8. 角家健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 外丸詩野

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 石津明洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimizu Tomohiro 清水 智弘

Research Projects

Research Products

Co-Researchers

Elucidation of innate immune disorders that regulate joint destruction and joint degeneration after fracture

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

抗炎症性マクロファージ由来因子と骨関連細胞に着目した新規骨粗鬆症メカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

炎症収束性貪食細胞由来細胞外小胞による関節炎収束メカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

特発性大腿骨頭壊死症の発生・圧潰と自然免疫異常の関連Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Bone fragility induced by tissue disoreder of mineral crystals and collargen in chronic kidney diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cardiotrophin Like Cytokine Factor 1 (CLCF1) alleviates bone loss in osteoporosis mouse models by suppressing osteoclast differentiation through activating interferon signaling and repressing the nuclear factor-κB signaling pathway.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of whole-body modalities for diagnosis of multifocal osteonecrosis-a pilot study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ten years change in post-fracture care for hip fracture patients.2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Blockade of XCL1/Lymphotactin Ameliorates Severity of Periprosthetic Osteolysis Triggered by Polyethylene-Particles2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of Neutrophil Extracellular Traps with the Development of Idiopathic Osteonecrosis of the Femoral Head2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Potential association with early changes in serum calcium level after starting or switching to denosumab combined with eldecalcitol.2019

Author(s)

Journal Title

Data Source

[Journal Article] Optimal administration frequency and dose of teriparatide for acceleration of biomechanical healing of long-bone fracture in a mouse model2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Potential association with early changes in serum calcium level after starting or switching to denosumab combined with eldecalcitol2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficacy and safety of osteoporosis medications in a rat model of late-stage chronic kidney disease accompanied by secondary hyperparathyroidism and hyperphosphatemia2017

Shimizu Tomohiro 清水智弘

[Presentation] 手術加療を施行した脆弱性骨折における術後骨粗鬆症検査・治療介入率の検証－北海道10年多施設後ろ向きコホート－2018