Hara Miki 原実生

Researcher Number	60848266
Other IDs	https://orcid.org/0000-0001-9281-3276
Affiliation (Current)	2025: 新潟大学, 医歯学系, 助教
Affiliation (based on the past Project Information) *help	2024 – 2025: 新潟大学, 医歯学系, 助教 2023: 新潟大学, 医歯学総合研究科, 研究員 2019 – 2021: 新潟大学, 医歯学総合研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 57030:Conservative dentistry-related / 0907:Oral science and related fields Except Principal Investigator Basic Section 57030:Conservative dentistry-related / Medium-sized Section 57:Oral science and related fields
Keywords	Principal Investigator 歯周炎 / ペリオドンタルメディスン / 歯周病 / 歯肉上皮バリア / P. gingivalis / 歯周炎治療薬 / 創傷治癒 / 歯牙結紮歯周炎モデル / 上皮系バリアシステム / ANGPTL4 … More / TRPチャネル / カプサイシン / TRPV1受容体 / TRPVチャネル / TRPV1 / TRPチャネルタンパク / 上皮バリア … More Except Principal Investigator 骨再生 / 老化細胞 / DEL-1 / 老化制御 / 歯周組織再生 / 口腔粘膜修復 / 骨再生能 / 幹細胞 / 老化ニッチ / 骨免疫 / 骨代謝 / 老化幹細胞ニッチ / 口腔老化 Less

Elucidation of the alteration mechanism of senescent stem cells and activation of their regenerative ability through its regulation
- Principal Investigator
  
  前川知樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Niigata University
歯周病原細菌による呼吸器上皮バリア機能破綻と肺がん発症機構を解明するPrincipal Investigator
- Principal Investigator
  
  原実生
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Niigata University
Understanding oral aging mechanisms by focusing on the oral stem cell niche
- Principal Investigator
  
  前川知樹
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Niigata University
ANGPTL4 on the Regulation of Gingival Epithelial Barrier and Wound HealingPrincipal Investigator
- Principal Investigator
  
  Hara Miki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Niigata University
Modulation of gingival epithelial barrier function by TRP channel proteinsPrincipal Investigator
- Principal Investigator
  
  Hara Miki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0907:Oral science and related fields
- Research Institution
  Niigata University

All 2023 2021 2020 2019

All Journal Article Presentation

[Journal Article] Macrolides Decrease the Proinflammatory Activity of Macrolide-Resistant Streptococcus pneumoniae2023
- Author(s)
  Domon Hisanori、Hirayama Satoru、Isono Toshihito、Sasagawa Karin、Takizawa Fumio、Maekawa Tomoki、Yanagihara Katsunori、Terao Yutaka
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 11 Issue: 3
- DOI
  10.1128/spectrum.00148-23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18355, KAKENHI-PROJECT-23KK0160, KAKENHI-PROJECT-22K09923, KAKENHI-PROJECT-22KJ1445, KAKENHI-PROJECT-23K24525
[Journal Article] Rice peptide with amino acid substitution inhibits biofilm formation by Porphyromonas gingivalis and Fusobacterium nucleatum2021
- Author(s)
  Matsugishi Aoi、Aoki-Nonaka Yukari、Yokoji-Takeuchi Mai、Yamada-Hara Miki、Mikami Yoshikazu、Hayatsu Manabu、Terao Yutaka、Domon Hisanori、Taniguchi Masayuki、Takahashi Naoki、Yamazaki Kazuhisa、Tabeta Koichi
- Journal Title
  
  Archives of Oral Biology
  
  Volume: 121 Pages: 104956-104956
- DOI
  10.1016/j.archoralbio.2020.104956
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10126, KAKENHI-PROJECT-20K09903, KAKENHI-PROJECT-20K18503, KAKENHI-PROJECT-18KK0434, KAKENHI-PROJECT-19H03829, KAKENHI-PROJECT-19K22705, KAKENHI-PROJECT-19K24139
[Journal Article] Ingestion of Porphyromonas gingivalis exacerbates colitis via intestinal epithelial barrier disruption in mice2021
- Author(s)
  Tsuzuno Takahiro、Takahashi Naoki、Yamada‐Hara Miki、Yokoji‐Takeuchi Mai、Sulijaya Benso、Aoki‐Nonaka Yukari、Matsugishi Aoi、Katakura Kyoko、Tabeta Koichi、Yamazaki Kazuhisa
- Journal Title
  
  Journal of Periodontal Research
  
  Volume: 56 Issue: 2 Pages: 275-288
- DOI
  10.1111/jre.12816
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H04067, KAKENHI-PROJECT-19K10126, KAKENHI-PROJECT-20K18503, KAKENHI-PROJECT-18KK0434
[Journal Article] Oral Pathobiont-Induced Changes in Gut Microbiota Aggravate the Pathology of Nonalcoholic Fatty Liver Disease in Mice2021
- Author(s)
  Yamazaki Kyoko、Kato Tamotsu、Tsuboi Yuuri、Miyauchi Eiji、Suda Wataru、Sato Keisuke、Nakajima Mayuka、Yokoji-Takeuchi Mai、Yamada-Hara Miki、Tsuzuno Takahiro、Matsugishi Aoi、Takahashi Naoki、Tabeta Koichi、Miura Nobuaki、Okuda Shujiro、Kikuchi Jun、Ohno Hiroshi、Yamazaki Kazuhisa
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 766170-766170
- DOI
  10.3389/fimmu.2021.766170
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10126, KAKENHI-PROJECT-20K18502, KAKENHI-PROJECT-20K18503, KAKENHI-PROJECT-19K05907, KAKENHI-PROJECT-21K19592, KAKENHI-PROJECT-18KK0434
[Journal Article] Obesity-Related Gut Microbiota Aggravates Alveolar Bone Destruction in Experimental Periodontitis through Elevation of Uric Acid2021
- Author(s)
  Sato Keisuke、Yamazaki Kyoko、Kato Tamotsu、Nakanishi Yumiko、Tsuzuno Takahiro、Yokoji-Takeuchi Mai、Yamada-Hara Miki、Miura Nobuaki、Okuda Shujiro、Ohno Hiroshi、Yamazaki Kazuhisa
- Journal Title
  
  mBio
  
  Volume: 12 Issue: 3
- DOI
  10.1128/mbio.00771-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18502, KAKENHI-PROJECT-20K18503, KAKENHI-PROJECT-21K19592
[Journal Article] Rice bran-derived protein fractions enhance sulforaphane-induced anti-oxidative activity in gingival epithelial cells2021
- Author(s)
  Mineo Shuhei、Takahashi Naoki、Yamada-Hara Miki、Tsuzuno Takahiro、Aoki-Nonaka Yukari、Tabeta Koichi
- Journal Title
  
  Archives of Oral Biology
  
  Volume: 129 Pages: 105215-105215
- DOI
  10.1016/j.archoralbio.2021.105215
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10126, KAKENHI-PROJECT-20K18503, KAKENHI-PROJECT-21K19592, KAKENHI-PROJECT-18KK0434
[Journal Article] Epithelial TRPV1 channels: Expression, function, and pathogenicity in the oral cavity2020
- Author(s)
  Takahashi Naoki、Tsuzuno Takahiro、Mineo Shuhei、Yamada-Hara Miki、Aoki-Nonaka Yukari、Tabeta Koichi
- Journal Title
  
  Journal of Oral Biosciences
  
  Volume: 62 Issue: 3 Pages: 235-241
- DOI
  10.1016/j.job.2020.05.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10126, KAKENHI-PROJECT-20K18503, KAKENHI-PROJECT-18KK0434, KAKENHI-PROJECT-19K24139
[Journal Article] Epithelial TRPV1 channels: Expression, function, and pathogenicity in the oral cavity2020
- Author(s)
  Takahashi Naoki, Tsuzuno Takahiro, Mineo Shuhei, Yamada-Hara Miki, Aoki-Nonaka Yukari, Tabeta Koichi
- Journal Title
  
  Journal of Oral Biosciences
  
  Volume: in press
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24139
[Journal Article] A bacterial metabolite induces Nrf2-mediated anti-oxidative responses in gingival epithelial cells by activating the MAPK signaling pathway2020
- Author(s)
  Yokoji-Takeuchi Mai、Takahashi Naoki、Yamada-Hara Miki、Sulijaya Benso、Tsuzuno Takahiro、Aoki-Nonaka Yukari、Tabeta Koichi、Kishino Shigenobu、Ogawa Jun、Yamazaki Kazuhisa
- Journal Title
  
  Archives of Oral Biology
  
  Volume: 110 Pages: 104602-104602
- DOI
  10.1016/j.archoralbio.2019.104602
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10126, KAKENHI-PROJECT-19K24139, KAKENHI-PROJECT-18KK0434, KAKENHI-PROJECT-18H04067
[Journal Article] Antimicrobial function of the polyunsaturated fatty acid KetoC in an experimental model of periodontitis2019
- Author(s)
  Sulijaya Benso、Yamada‐Hara Miki、Yokoji‐Takeuchi Mai、Matsuda‐Matsukawa Yumi、Yamazaki Kyoko、Matsugishi Aoi、Tsuzuno Takahiro、Sato Keisuke、Aoki‐Nonaka Yukari、Takahashi Naoki、Kishino Shigenobu、Ogawa Jun、Tabeta Koichi、Yamazaki Kazuhisa
- Journal Title
  
  Journal of Periodontology
  
  Volume: 90 Issue: 12 Pages: 1470-1480
- DOI
  10.1002/jper.19-0130
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10126, KAKENHI-PROJECT-19K18990, KAKENHI-PROJECT-19K24139, KAKENHI-PROJECT-18KK0434, KAKENHI-PROJECT-18H04067
[Journal Article] Gingival epithelial barrier: regulation by beneficial and harmful microbes2019
- Author(s)
  Takahashi Naoki、Sulijaya Benso、Yamada-Hara Miki、Tsuzuno Takahiro、Tabeta Koichi、Yamazaki Kazuhisa
- Journal Title
  
  Tissue Barriers
  
  Volume: 7 Issue: 3 Pages: e1651158-e1651158
- DOI
  10.1080/21688370.2019.1651158
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10126, KAKENHI-PROJECT-19K24139, KAKENHI-PROJECT-18KK0434
[Presentation] 腸内細菌叢の変動を介した歯周病のNAFLDへの影響2020
- Author(s)
  2)山崎恭子, 中島麻由佳, 竹内麻衣，原実生，都野隆博, 松岸葵, 松川由実，佐藤圭祐，高橋直紀，多部田康一，坪井裕理，菊池　淳，加藤　完，大野博司，山崎和久
- Organizer
  第24回腸内細菌学会
- Data Source
  KAKENHI-PROJECT-20K18503
[Presentation] 歯肉上皮細胞に発現するTRPV1活性化による抗炎症性作用の解析2020
- Author(s)
  都野隆博、高橋直紀、峯尾修平、原実生、野中由香莉、多部田康一
- Organizer
  日本歯科保存学会　2020年度春季学術大会
- Data Source
  KAKENHI-PROJECT-19K24139
[Presentation] 歯肉上皮細胞に発現するTRPV1活性化による抗炎症作用の解析2020
- Author(s)
  1)都野隆博, 高橋直紀，峰尾修平，原実生, 野中由香莉, 多部田康一
- Organizer
  第152回日本歯科保存学会2020年度春季学術大会
- Data Source
  KAKENHI-PROJECT-20K18503
[Presentation] コメペプチドとそのアミノ酸置換体はPorphyromonas gingivalis, Fusobacterium nucleatumのバイオフィルム形成を阻害する2020
- Author(s)
  7)松岸葵,野中由香莉，竹内麻衣, 原実生,早津　学，三上剛和，牛木辰男，土門久哲，山崎和久，多部田康一
- Organizer
  第63回春季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-19K24139
[Presentation] 腸内細菌叢の変動を介した歯周病のNAFLDへの影響2020
- Author(s)
  2)山崎恭子, 中島麻由佳, 竹内麻衣，原実生，都野隆博, 松岸葵, 松川由実，佐藤圭祐，高橋直紀，多部田康一，坪井裕理，菊池　淳，加藤　完，大野博司，山崎和久
- Organizer
  第24回腸内細菌学会
- Data Source
  KAKENHI-PROJECT-19K24139
[Presentation] 上皮細胞に発現するTRPV1活性化による抗炎症作用の解析2020
- Author(s)
  都野隆博, 高橋直紀，峰尾修平，原実生, 野中由香莉, 多部田康一
- Organizer
  第152回日本歯科保存学会
- Data Source
  KAKENHI-PROJECT-19K24139

1. 前川知樹 (50625168)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. 都野隆博 (40907383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 日吉巧 (80911437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 土門久哲 (00594350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 多部田康一 (20401763)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. 米澤大輔 (90711896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 高橋直紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
8. 山崎和久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 寺尾豊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 平山悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 佐藤圭祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hara Miki 原 実生

Research Projects

Research Products

Co-Researchers

Elucidation of the alteration mechanism of senescent stem cells and activation of their regenerative ability through its regulation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

歯周病原細菌による呼吸器上皮バリア機能破綻と肺がん発症機構を解明するPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding oral aging mechanisms by focusing on the oral stem cell niche

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ANGPTL4 on the Regulation of Gingival Epithelial Barrier and Wound HealingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Modulation of gingival epithelial barrier function by TRP channel proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Macrolides Decrease the Proinflammatory Activity of Macrolide-Resistant Streptococcus pneumoniae2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rice peptide with amino acid substitution inhibits biofilm formation by Porphyromonas gingivalis and Fusobacterium nucleatum2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ingestion of Porphyromonas gingivalis exacerbates colitis via intestinal epithelial barrier disruption in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oral Pathobiont-Induced Changes in Gut Microbiota Aggravate the Pathology of Nonalcoholic Fatty Liver Disease in Mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Obesity-Related Gut Microbiota Aggravates Alveolar Bone Destruction in Experimental Periodontitis through Elevation of Uric Acid2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rice bran-derived protein fractions enhance sulforaphane-induced anti-oxidative activity in gingival epithelial cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epithelial TRPV1 channels: Expression, function, and pathogenicity in the oral cavity2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epithelial TRPV1 channels: Expression, function, and pathogenicity in the oral cavity2020

Author(s)

Journal Title

Data Source

[Journal Article] A bacterial metabolite induces Nrf2-mediated anti-oxidative responses in gingival epithelial cells by activating the MAPK signaling pathway2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antimicrobial function of the polyunsaturated fatty acid KetoC in an experimental model of periodontitis2019

Author(s)

Hara Miki 原実生