Yokomizo Hisashi 横溝久

Researcher Number	60866747
Other IDs	https://orcid.org/0000-0001-7759-2014
Affiliation (Current)	2025: 福岡大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2024: 福岡大学, 医学部, 准教授 2022 – 2024: 福岡大学, 医学部, 講師 2020 – 2023: 九州大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related / Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Basic Section 57030:Conservative dentistry-related / Medium-sized Section 57:Oral science and related fields
Keywords	Principal Investigator 糖尿病合併症 / 糖尿病性腎症 / エネルギー代謝 / 速筋 / 遅筋 / SGLT2阻害薬 / 骨格筋代謝 / 骨格筋障害 / 糖尿病 Except Principal Investigator 糸球体 … More / PGD2 / HPGDS / 歯周医学 / 歯周炎 / 糖尿病性腎症 / 褐色脂肪 / 肥満 / 歯周病 / 統合オミクス解析 / 遺伝子改変マウス / RNA-sequence / プロテオミクス / メタボロミクス / 糖尿病関連歯周炎 Less

Elucidation of residual pathophysiology and development of new treatment by focusing on PKM2, a protective factor for diabetic nephropathyPrincipal Investigator
- Principal Investigator
  
  横溝久
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Fukuoka University
新規BATkineに着目した歯周病による代謝破綻の解明
- Principal Investigator
  
  佐々木直樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Tokyo Medical and Dental University
The molecular mechanism in the association of periodontitis and diabetic nephropathy via PGD2 signaling
- Principal Investigator
  
  新城尊徳
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Kyushu University
代謝特性の異なる遅筋と速筋に着目した糖尿病における骨格筋障害の発症機構の解明Principal Investigator
- Principal Investigator
  
  横溝久
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Fukuoka University
  Kyushu University
統合オミクス解析を介した糖尿病性歯周炎の病態解明を目指す国際共同研究
- Principal Investigator
  
  西村英紀
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kyushu University

All 2023 2022 2021

All Journal Article Presentation

[Journal Article] Dysregulation of CXCL1 Expression and Neutrophil Recruitment in Insulin Resistance and Diabetes-Related Periodontitis in Male Mice2023
- Author(s)
  Shinjo Takanori、Onizuka Satoru、Zaitsu Yumi、Ishikado Atsushi、Park Kyoungmin、Li Qian、Yokomizo Hisashi、Zeze Tatsuro、Sato Kohei、St-Louis Ronald、Fu Jialin、I-Hsien Wu、Mizutani Koji、Hasturk Hatice、Van Dyke Thomas E.、Nishimura Fusanori、King George L.
- Journal Title
  
  Diabetes
  
  Volume: 72 Issue: 7 Pages: 986-998
- DOI
  10.2337/db22-1014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0212, KAKENHI-PROJECT-23K09170, KAKENHI-PROJECT-20K18513
[Journal Article] Improved endurance capacity of diabetic mice during SGLT2 inhibition: Potential role of AICARP, an endogenous AMPK activator in the soleus muscle.2023
- Author(s)
  Nakamura S, Miyachi Y*, Shinjo A, Yokomizo H, Takahashi M, Nakatani K, Izumi Y, Otsuka H, Sato N, Sakamoto R, Miyazawa T, Bamba T, Ogawa Y*.
- Journal Title
  
  Journal of Cachexia, Sarcopenia and Muscle
  
  Volume: 14 Issue: 6 Pages: 2866-2881
- DOI
  10.1002/jcsm.13350
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18924, KAKENHI-PROJECT-21K14472, KAKENHI-PROJECT-21K16371, KAKENHI-PROJECT-23K17200, KAKENHI-PROJECT-22K08673, KAKENHI-PLANNED-22H05185, KAKENHI-PROJECT-22H04993
[Journal Article] Differential effect of canagliflozin, a sodium-glucose cotransporter (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice.2022
- Author(s)
  Otsuka H, Yokomizo H*, Nakamura S, Izumi Y, Takahashi M, Obara S, Nakao M, Ikeda Y, Sato N, Sakamoto R, Miyachi Y, Miyazawa T, Bamba T, Ogawa Y*.
- Journal Title
  
  Biochem. J.
  
  Volume: 479(3) Issue: 3 Pages: 425-444
- DOI
  10.1042/bcj20210700
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05167, KAKENHI-PROJECT-19K08983, KAKENHI-PLANNED-17H06304, KAKENHI-PROJECT-19H01054, KAKENHI-PROJECT-21K16371, KAKENHI-PROJECT-20K15101
[Journal Article] Regeneration of glomerular metabolism and function by podocyte pyruvate kinase M2 in diabetic nephropathy2022
- Author(s)
  Fu Jialin、Shinjo Takanori、Li Qian、St-Louis Ronald、Park Kyoungmin、Yu Marc G.、Yokomizo Hisashi、Simao Fabricio、Huang Qian、Wu I-Hsien、King George L.
- Journal Title
  
  JCI Insight
  
  Volume: 7 Issue: 5
- DOI
  10.1172/jci.insight.155260
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-20KK0212
[Journal Article] Endothelial cells induced progenitors into brown fat to reduce atherosclerosis2022
- Author(s)
  Park K, Li Q, Lynes MD, Yokomizo H, Maddaloni E, Shinjo T, St-Louis R, Li Q, Katagiri S, Fu J, Clermont A, Park H, Wu IH, Yu MG, Shah H, Tseng YH, King GL
- Journal Title
  
  Circulation Research
  
  Volume: 131 Issue: 2 Pages: 168-183
- DOI
  10.1161/circresaha.121.319582
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19590, KAKENHI-PROJECT-20K18513, KAKENHI-PROJECT-20KK0212, KAKENHI-PROJECT-20H03863
[Presentation] SGLT２阻害薬はAICARP／AMPK 経路の活性化により糖尿病マウスの遅筋機能を改善させる2023
- Author(s)
  中村慎太郎、宮地康高、横溝久、大塚裕子、新城明仁、和泉自泰、高橋政友、中谷航太、坂本竜一、馬場健史、小川佳宏
- Organizer
  第23回日本内分泌学会九州支部学術集会
- Data Source
  KAKENHI-PROJECT-21K16371
[Presentation] 実験的歯周炎によって2型糖尿病モデルKK-Ayマウスにおける腎症は増悪する2023
- Author(s)
  新城尊徳, 佐藤晃平, 横溝久, 瀬々起朗, 今川澪, 岩下未咲, 山下明子, 西村英紀
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-23K09170
[Presentation] カナグリフロジンは遅筋内のAICARPを増加させAMPKの活性化による代謝亢進を介して肥満糖尿病マウスの遅筋機能を改善させる2023
- Author(s)
  中村慎太郎，宮地康高，横溝久，大塚裕子，和泉自泰，高橋政友，佐藤直市，坂本竜一，宮澤崇，馬場健史，小川佳宏
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K16371
[Presentation] 代謝特性に着目したカナグリフロジンの遅筋と速筋の代謝調節作用の解明2022
- Author(s)
  大塚裕子、横溝久、中村慎太郎、佐藤直市、坂本竜一、宮地康高、宮澤崇、和泉自泰、馬場健史、小川佳宏
- Organizer
  第60回日本糖尿病学会九州地方会
- Data Source
  KAKENHI-PROJECT-21K16371
[Presentation] SGLT2阻害薬が肥満糖尿病マウスの骨格筋代謝に与える影響の検討2022
- Author(s)
  中村慎太郎、横溝久、大塚裕子、和泉自泰、高橋政友、佐藤直市、坂本竜一、宮地康高、宮澤崇、馬場健史、小川佳宏
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K16371
[Presentation] 代謝特性の異なる遅筋と速筋に着目した、SGLT2阻害薬の骨格筋代謝調節の解明2022
- Author(s)
  中村慎太郎、横溝久、大塚裕子、和泉自泰、高橋政友、佐藤直市、坂本竜一、宮地康高、宮澤崇、馬場健史、小川佳宏
- Organizer
  第35回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K16371
[Presentation] 代謝特性の異なる遅筋と速筋に着目したSGLT2阻害薬の骨格筋代謝調節作用の解明2022
- Author(s)
  横溝久、大塚裕子、中村慎太郎、園田紀之、宮澤崇、和泉自泰、高橋政友、馬場健史、小川佳宏
- Organizer
  第42回日本肥満学会
- Data Source
  KAKENHI-PROJECT-21K16371
[Presentation] SGLT2阻害薬の骨格筋代謝調節作用2021
- Author(s)
  大塚裕子、横溝久、中村慎太郎、園田紀之、宮澤崇、和泉自泰、馬場健史、小川佳宏
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K16371

1. 新城尊徳 (20711394)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 西村英紀 (80208222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 小川佳宏 (70291424)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 升谷耕介 (30419593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 川浪大治 (50568889)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 佐々木直樹 (40848305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 畑佐将宏 (20991839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 片桐さやか (60510352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 岩下未咲 (80611326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 和泉自泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Yokomizo Hisashi 横溝 久

Research Projects

Research Products

Co-Researchers

Elucidation of residual pathophysiology and development of new treatment by focusing on PKM2, a protective factor for diabetic nephropathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規BATkineに着目した歯周病による代謝破綻の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The molecular mechanism in the association of periodontitis and diabetic nephropathy via PGD2 signaling

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

代謝特性の異なる遅筋と速筋に着目した糖尿病における骨格筋障害の発症機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

統合オミクス解析を介した糖尿病性歯周炎の病態解明を目指す国際共同研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Dysregulation of CXCL1 Expression and Neutrophil Recruitment in Insulin Resistance and Diabetes-Related Periodontitis in Male Mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Improved endurance capacity of diabetic mice during SGLT2 inhibition: Potential role of AICARP, an endogenous AMPK activator in the soleus muscle.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential effect of canagliflozin, a sodium-glucose cotransporter (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regeneration of glomerular metabolism and function by podocyte pyruvate kinase M2 in diabetic nephropathy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endothelial cells induced progenitors into brown fat to reduce atherosclerosis2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] SGLT２阻害薬はAICARP／AMPK 経路の活性化により糖尿病マウスの遅筋機能を改善させる2023

Author(s)

Organizer

Data Source

[Presentation] 実験的歯周炎によって2型糖尿病モデルKK-Ayマウスにおける腎症は増悪する2023

Author(s)

Organizer

Data Source

[Presentation] カナグリフロジンは遅筋内のAICARPを増加させAMPKの活性化による代謝亢進を介して肥満糖尿病マウスの遅筋機能を改善させる2023

Author(s)

Organizer

Data Source

[Presentation] 代謝特性に着目したカナグリフロジンの遅筋と速筋の代謝調節作用の解明2022

Author(s)

Organizer

Data Source

[Presentation] SGLT2阻害薬が肥満糖尿病マウスの骨格筋代謝に与える影響の検討2022

Author(s)

Organizer

Data Source

[Presentation] 代謝特性の異なる遅筋と速筋に着目した、SGLT2阻害薬の骨格筋代謝調節の解明2022

Yokomizo Hisashi 横溝久