Nakashima Yu 中嶋優

Researcher Number	60902038
Other IDs	https://orcid.org/0000-0001-7788-8333
Affiliation (Current)	2026: 富山大学, 学術研究部薬学・和漢系, 助教
Affiliation (based on the past Project Information) *help	2022 – 2026: 富山大学, 学術研究部薬学・和漢系, 助教
Review Section/Research Field	Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related Except Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related / Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Keywords	Principal Investigator 漢方 / 阻害剤 / 生薬 / 2OG依存性酸化酵素 / FIH / AspH Except Principal Investigator 酵素機能改変 / 生合成 / アルカロイド

MAFLD治療を指向した伝統生薬由来FIH非キレート阻害剤の探索Principal Investigator
- Principal Investigator
  
  中嶋優
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  University of Toyama
神経軸索伸長活性アルカロイドの創出を指向したアルカロイド生合成酵素の機能改変
- Principal Investigator
  
  森田洋行
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  University of Toyama
Functional analysis and engineering of biosynthetic enzymes for the formation of Alkaloid scaffold with AchE inhibitory activity.
- Principal Investigator
  
  Morita Hiroyuki
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  University of Toyama
FIHを標的とした代謝異常関連脂肪肝MAFLDの治療に有効なシード化合物の探索Principal Investigator
- Principal Investigator
  
  中嶋優
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  University of Toyama
Searching for effective anti-cancer seed compounds for refractory cancers targeting AspHPrincipal Investigator
- Principal Investigator
  
  Nakashima Yu
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  University of Toyama

All 2025 2024 2023 2022

All Journal Article Presentation

[Journal Article] Substrate Flexibilities of Norbelladine Synthase and Noroxomaritidine/Norcraugsodine Reductase for Hydroxylated and/or Methoxylated Aldehydes2024
- Author(s)
  Hnin Saw Yu Yu、Nakashima Yu、Morita Hiroyuki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 5 Pages: 507-511
- DOI
  10.1248/cpb.c24-00174
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-05-28
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24040
[Journal Article] Three <i>neo</i>-Clerodane Diterpenoids from <i>Tinospora cordifolia</i> Stems and Their Arginase Inhibitory Activities2024
- Author(s)
  Hoang Nhat Nam、Hoshino Shotaro、Kodama Takeshi、Nakashima Yu、Do Kiep Minh、Thao Hoang Xuan、Ikumi Naotaka、Onaka Hiroyasu、Morita Hiroyuki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 6 Pages: 540-546
- DOI
  10.1248/cpb.c24-00240
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-06-12
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24040, KAKENHI-PROJECT-23K06179
[Journal Article] Structure-Based Catalytic Mechanism of Amaryllidaceae O-Methyltransferases2024
- Author(s)
  Hnin Saw Y. Y.、Nakashima Yu、Kodama Takeshi、Morita Hiroyuki
- Journal Title
  
  ACS Catalysis
  
  Volume: 14 Issue: 15 Pages: 11865-11880
- DOI
  10.1021/acscatal.4c03305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24040, KAKENHI-PROJECT-23K06179
[Journal Article] Phenolic Derivatives with Anti‐Acetylcholinesterase Inhibitory Activities from Galeola nudifolia in Vietnam2023
- Author(s)
  Do Kiep Minh、Nakashima Yu、Kodama Takeshi、Lee Yuan‐E、Nguyen Hien Minh、Ikumi Naotaka、Morita Hiroyuki
- Journal Title
  
  Chemistry & Biodiversity
  
  Volume: 20 Issue: 12 Pages: 202301482-202301482
- DOI
  10.1002/cbdv.202301482
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06179, KAKENHI-PROJECT-23K24040
[Journal Article] Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes2023
- Author(s)
  Hoang Nhat Nam、Kodama Takeshi、Nakashima Yu、Do Kiep Minh、Hnin Saw Yu Yu、Lee Yuan-E、Prema、Ikumi Naotaka、Morita Hiroyuki
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 77 Issue: 4 Pages: 891-897
- DOI
  10.1007/s11418-023-01731-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06179, KAKENHI-PROJECT-23K24040
[Journal Article] Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism2023
- Author(s)
  Nakashima Yu、Kawakami Atsushi、Ogasawara Yasushi、Maeki Masatoshi、Tokeshi Manabu、Dairi Tohru、Morita Hiroyuki
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 4752-4752
- DOI
  10.1038/s41467-023-40232-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22H05130, KAKENHI-PROJECT-22H04976, KAKENHI-PROJECT-23K24040
[Journal Article] Enzymatic formation of a prenyl β-carboline by a fungal indole prenyltransferase2022
- Author(s)
  Hamdy Sherif Ahmed、Kodama Takeshi、Nakashima Yu、Han Xiaojie、Matsui Takashi、Morita Hiroyuki
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 76 Issue: 4 Pages: 873-879
- DOI
  10.1007/s11418-022-01635-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06036, KAKENHI-PROJECT-23K24040
[Journal Article] Catalytic potential of a fungal indole prenyltransferase toward b-carbolines, harmine and harman, and their prenylation effect on antibacterial activities2022
- Author(s)
  SA. Hamdy、T. Kodama、 Y. Nakashima、 X. Han、H. Morita
- Journal Title
  
  J Biosci Bioeng
  
  Volume: 134 Issue: 4 Pages: 311-317
- DOI
  10.1016/j.jbiosc.2022.07.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] Furanocoumarins from Angelica dahurica as Natural Inhibitor of Factor Inhibiting Hypoxia-Inducible-Factor-1α (FIH)2025
- Author(s)
  Ginsha Zakatina Rahman, Yu Nakashima, Lennart Brewitz, Yochidamai Akhsanitaqwim, Christopher J. Schofield, Hiroyuki Morita
- Organizer
  日本薬学会第145年会
- Data Source
  KAKENHI-PROJECT-24K18295
[Presentation] Furanocoumarins from Angelica dahurica as Natural Inhibitor of Factor Inhibiting Hypoxia-Inducible-Factor-1α (FIH)2025
- Author(s)
  Ginsha Zakatina Rahman, Yu Nakashima, Lennart Brewitz, Yochidamai Akhsanitaqwim, Christopher J. Schofield, Hiroyuki Morita
- Organizer
  日本薬学会第145年会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] ペプチドグリカンの生合成に関与する新規ペプチオエピメラーゼMurLの反応機構解析2024
- Author(s)
  堀内柾希, 中嶋優, 角田毅, 森田洋行, 小笠原泰志, 大利徹
- Organizer
  第38回（2024年度）日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] The structural-guided studies for Amaryllidaceae O-methyltransferases2024
- Author(s)
  Hnin SYY, Nakashima Y, Kodama T, Morita H.
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] X線結晶構造解析に基づくペプチドグリカン生合成に寄与する新規ペプチドエピメラーゼMurLの機能解析2024
- Author(s)
  中嶋優, 堀内柾希, 角田毅, 小笠原泰志, 大利徹, 森田洋行
- Organizer
  第10回食品薬学シンポジウム
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] Phenolic derivatives with acetylcholinesterase inhibitory activities from Galeola nudifolia in Vietnam2024
- Author(s)
  Hnin Saw Yu Yu, Do Kiep Minh, Nakashima Y, Kodama T, Morita H
- Organizer
  日本生薬学会第70 回年会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] X線結晶構造解析に基づくAmaryllidaceae O-methyltransferasesの触媒機構の解析2024
- Author(s)
  Hnin SYY, 中嶋優, 児玉猛，森田洋行
- Organizer
  第10回食品薬学シンポジウム
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] 7-hydroxytryptophanを有するlassoペプチドRes701-2の生合成研究2024
- Author(s)
  山谷優花, 角田毅, 中嶋優, 丸山千登勢, 濱野吉十, 森田洋行, 小笠原泰志, 大利徹
- Organizer
  第38回（2024年度）日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] Catalytic potential of O-methyltransferase in the biosynthesis of Amaryllidaceae alkaloids with different substrates2023
- Author(s)
  Saw Yu Yu Hnin, Yu Nakashima, Takeshi Kodama, Hiroyuki Morita
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] X線結晶構造解析に基づくラッソペプチドエピメリ化酵素MslHの酵素反応機構の解明2023
- Author(s)
  中嶋優，川上篤士，小笠原泰志，大利徹，森田洋行
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] ラッソペプチドのエピメリ化を担うMslHの結晶構造解析2023
- Author(s)
  中嶋優，川上篤士，小笠原泰志，大利徹，森田洋行
- Organizer
  酵素工学研究会第90回講演会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] ラッソペプチド生合成を担うエピメリ化酵素MslH のX 線結晶構造解析(第2)．2023
- Author(s)
  中嶋優，川上篤士，小笠原泰志，大利徹，森田洋行
- Organizer
  日本生薬学会第69回年会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] Structural-based engineering of Amaryllidaceae-O-methyltransferases (2nd)．2023
- Author(s)
  Hnin SYY, Nakashima Y, Kodama T, Morita H．
- Organizer
  日本生薬学会第69回年会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] X-ray crystallographic analysis of lasso peptide epimerase; MslH2023
- Author(s)
  Yu Nakashima, Atsushi Kawakami, Yasushi Ogasawara, Tohru Dairi, Hiroyuki Morita
- Organizer
  4th International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] Crystal structure analysis of norbelladine 4-O-methyltransferase from Lycoris longituba2023
- Author(s)
  Saw Yu Yu Hnin, Yu Nakashima, Takeshi Kodama, Hiroyuki Morita
- Organizer
  4th International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] Dual engineering of olivetolic acid cyclase and tetraketide synthase to generate longer alkyl-chain olivetolic acid analogs2023
- Author(s)
  Yuan-E Lee, Yu Nakashima, Takeshi Kodama, Hiroyuki Morita
- Organizer
  4th International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] Identification of a diarylpentanoid-producing polyketide synthase in the biosynthesis of 2-(2-phenylethyl)chromones in agarwood2023
- Author(s)
  Hiroyuki Morita, Xiao-Hui Wang, Bo-Wen Gao, Yu Nakashima, Ikuro Abe, Peng-Fei Tu, She-Po Shi
- Organizer
  4th International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] 新規ペプチドエピメラーゼMslHの反応機構解析2022
- Author(s)
  川上篤士，中嶋優，森田洋行，小笠原泰志，大利徹
- Organizer
  第36回日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] Structural-based engineering of norbelladine-O-methyltransferase2022
- Author(s)
  Saw Yu Yu Hnin, Yu Nakashima, Takeshi Kodama, Hiroyuki Morita
- Organizer
  日本生薬学会第 68 回年会
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] Dual engineering of olivetolic acid cyclase and tetraketide synthase to generate longer alkyl-chain olivetolic acid analogs2022
- Author(s)
  Yuan-E Lee, Yu Nakashima, Takeshi Kodama, Xinrui Chen, Hiroyuki Morita
- Organizer
  Active Enzyme Molecule 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24040
[Presentation] ラッソペプチド生合成を担うエピメリ化酵素MslHのX線結晶構造解析2022
- Author(s)
  中嶋優，川上篤士，小笠原泰志，大利徹，森田洋行
- Organizer
  日本生薬学会第 68 回年会
- Data Source
  KAKENHI-PROJECT-23K24040

1. Morita Hiroyuki (20416663)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
2. 児玉猛 (40710207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
3. 松井崇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 小笠原泰志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakashima Yu 中嶋 優

Research Projects

Research Products

Co-Researchers

MAFLD治療を指向した伝統生薬由来FIH非キレート阻害剤の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

神経軸索伸長活性アルカロイドの創出を指向したアルカロイド生合成酵素の機能改変

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis and engineering of biosynthetic enzymes for the formation of Alkaloid scaffold with AchE inhibitory activity.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

FIHを標的とした代謝異常関連脂肪肝MAFLDの治療に有効なシード化合物の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Searching for effective anti-cancer seed compounds for refractory cancers targeting AspHPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Substrate Flexibilities of Norbelladine Synthase and Noroxomaritidine/Norcraugsodine Reductase for Hydroxylated and/or Methoxylated Aldehydes2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Three <i>neo</i>-Clerodane Diterpenoids from <i>Tinospora cordifolia</i> Stems and Their Arginase Inhibitory Activities2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Structure-Based Catalytic Mechanism of Amaryllidaceae O-Methyltransferases2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phenolic Derivatives with Anti‐Acetylcholinesterase Inhibitory Activities from Galeola nudifolia in Vietnam2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enzymatic formation of a prenyl β-carboline by a fungal indole prenyltransferase2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Catalytic potential of a fungal indole prenyltransferase toward b-carbolines, harmine and harman, and their prenylation effect on antibacterial activities2022

Author(s)

Journal Title

DOI

Data Source

Nakashima Yu 中嶋優