Sonehara Kyuto 曽根原究人

Researcher Number	60975358
Other IDs
Affiliation (Current)	2026: 東京大学, 大学院医学系研究科(医学部), 客員研究員
Affiliation (based on the past Project Information) *help	2024 – 2025: 東京大学, 大学院医学系研究科(医学部), 客員研究員 2023: 東京大学, 大学院医学系研究科(医学部), 助教
Review Section/Research Field	Principal Investigator Basic Section 48040:Medical biochemistry-related Except Principal Investigator Basic Section 56030:Urology-related
Keywords	Principal Investigator 構造多型 / ロングリードシーケンス / 遺伝統計学 / MHC領域 / HLA遺伝子 / 全ゲノムシーケンス / ゲノムワイド関連解析 Except Principal Investigator シングルセル解析 / 全ゲノム関連解析 / リピドミクス解析 / オミクス解析 / ハンナ型間質性膀胱炎

横断的オミクス解析と機械学習による間質性膀胱炎の治療標的とバイオマーカーの開発
- Principal Investigator
  
  秋山佳之
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Shinshu University
Elucidating structural diversity and functional significance of the MHC region using long-read sequencingPrincipal Investigator
- Principal Investigator
  
  曽根原究人
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  The University of Tokyo
Genome-wide elucidation of disease susceptibility structural variation using short- and long-read sequencingPrincipal Investigator
- Principal Investigator
  
  Sonehara Kyuto
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  The University of Tokyo

All 2025 2024 2023

All Journal Article Presentation

[Journal Article] Germline variants and mosaic chromosomal alterations affect COVID-19 vaccine immunogenicity2025
- Author(s)
  Sonehara Kyuto、Uwamino Yoshifumi、Saiki Ryunosuke、et al.
- Journal Title
  
  Cell Genomics
  
  Volume: 5 Issue: 3 Pages: 100783-100783
- DOI
  10.1016/j.xgen.2025.100783
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-23H00424, KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-23K19564, KAKENHI-PROJECT-23K27608, KAKENHI-PROJECT-23K07951, KAKENHI-PROJECT-22KJ1190
[Journal Article] Contribution of germline and somatic mutations to risk of neuromyelitis optica spectrum disorder2025
- Author(s)
  Yata Tomohiro、Sato Go、Ogawa Kotaro、Naito Tatsuhiko、Sonehara Kyuto、et al.
- Journal Title
  
  Cell Genomics
  
  Volume: 5 Issue: 3 Pages: 100776-100776
- DOI
  10.1016/j.xgen.2025.100776
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-23K24246, KAKENHI-PROJECT-22K07351, KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-23K19564, KAKENHI-PROJECT-23K27608, KAKENHI-PROJECT-24K02371, KAKENHI-PROJECT-23K06923, KAKENHI-PROJECT-24K18685, KAKENHI-PROJECT-22KJ1190
[Journal Article] A genome-wide meta-analysis reveals shared and population-specific variants for allergic sensitization2025
- Author(s)
  Noguchi Emiko、Morii Wataru、Kitazawa Haruna、Hirota Tomomitsu、Sonehara Kyuto、Masuko Hironori、Okada Yukinori、Hizawa Nobuyuki
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 155 Issue: 4 Pages: 1321-1332
- DOI
  10.1016/j.jaci.2024.11.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-23K27833
[Journal Article] Retrotrans-genomics identifies aberrant THE1B endogenous retrovirus fusion transcripts in the pathogenesis of sarcoidosis2025
- Author(s)
  Funaguma Shunsuke、Iida Aritoshi、Saito Yoshihiko、Tanboon Jantima、De Los Reyes Francia Victoria、Sonehara Kyuto、Goto Yu-ichi、Okada Yukinori、Hayashi Shinichiro、Nishino Ichizo
- Journal Title
  
  Nature Communications
  
  Volume: 16 Issue: 1
- DOI
  10.1038/s41467-025-56567-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14451
[Journal Article] Incomplete human reference genomes can drive false sex biases and expose patient-identifying information in metagenomic data2025
- Author(s)
  Guccione Caitlin、Patel Lucas、Tomofuji Yoshihiko、McDonald Daniel、Gonzalez Antonio、Sepich-Poore Gregory D.、Sonehara Kyuto、Zakeri Mohsen、Chen Yang、Dilmore Amanda Hazel、Damle Neil、Baranzini Sergio E.、Hightower George、Nakatsuji Teruaki、Gallo Richard L.、Langmead Ben、Okada Yukinori、Curtius Kit、Knight Rob
- Journal Title
  
  Nature Communications
  
  Volume: 16 Issue: 1
- DOI
  10.1038/s41467-025-56077-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14451
[Journal Article] Blood DNA virome associates with autoimmune diseases and COVID-192025
- Author(s)
  Sasa Noah、Kojima Shohei、Koide Rie、Hasegawa Takanori、Namkoong Ho、et al.
- Journal Title
  
  Nature Genetics
  
  Volume: 57 Issue: 1 Pages: 65-79
- DOI
  10.1038/s41588-024-02022-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-23K21722, KAKENHI-PROJECT-20K08554, KAKENHI-PROJECT-21K08344, KAKENHI-PROJECT-22K08409, KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-23K21442, KAKENHI-PROJECT-23K07887, KAKENHI-PROJECT-24K11492, KAKENHI-PROJECT-24K12174, KAKENHI-PROJECT-24K12195, KAKENHI-PROJECT-24K18476
[Journal Article] Genetic drivers of heterogeneity in type 2 diabetes pathophysiology2024
- Author(s)
  Suzuki Ken、Hatzikotoulas Konstantinos、Southam Lorraine、Taylor Henry J.、Yin Xianyong、Lorenz Kim M.、Mandla Ravi、Huerta-Chagoya Alicia、Melloni Giorgio E. M.、Kanoni Stavroula、Rayner Nigel W.、Bocher Ozvan、Arruda Ana Luiza、Sonehara Kyuto et al.
- Journal Title
  
  Nature
  
  Volume: 627 Issue: 8003 Pages: 347-357
- DOI
  10.1038/s41586-024-07019-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-21H04850, KAKENHI-PROJECT-21H03206
[Journal Article] Brugada syndrome in Japan and Europe: a genome-wide association study reveals shared genetic architecture and new risk loci2024
- Author(s)
  Ishikawa T, Makita N et al.
- Journal Title
  
  European Heart Journal
  
  Volume: in press Issue: 26 Pages: 2320-2332
- DOI
  10.1093/eurheartj/ehae251
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02920, KAKENHI-PROJECT-21H02888, KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-24K11235
[Journal Article] Primary Aldosteronism and Risk of Cardiovascular Outcomes: Genome‐Wide Association and Mendelian Randomization Study2024
- Author(s)
  Inoue Kosuke、Naito Tatsuhiko、Fuji Ryosuke、Sonehara Kyuto、Yamamoto Kenichi、Baba Ryuta、Kodama Takaya、Otagaki Yu、Okada Akira、Itcho Kiyotaka、Kobuke Kazuhiro、Ohno Haruya、BioBank Japan、Morisaki Takayuki、Hattori Noboru、Goto Atsushi、Nishikawa Tetsuo、Oki Kenji、Okada Yukinori
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 13 Issue: 15
- DOI
  10.1161/jaha.123.034180
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18943, KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-22K20929
[Journal Article] Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss2024
- Author(s)
  Sonehara Kyuto、Yano Yoshitaka、Naito Tatsuhiko、Goto Shinobu、Yoshihara Hiroyuki、Otani Takahiro、Ozawa Fumiko、et al.
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 5744-5744
- DOI
  10.1038/s41467-024-49993-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-23K24486, KAKENHI-PROJECT-21K11791
[Journal Article] Machine learning reveals heterogeneous associations between environmental factors and cardiometabolic diseases across polygenic risk scores2024
- Author(s)
  Naito Tatsuhiko、Inoue Kosuke、Namba Shinichi、Sonehara Kyuto、Suzuki Ken、BioBank Japan、Matsuda Koichi、Kondo Naoki、Toda Tatsushi、Yamauchi Toshimasa、Kadowaki Takashi、Okada Yukinori
- Journal Title
  
  Communications Medicine
  
  Volume: 4 Issue: 1 Pages: 181-181
- DOI
  10.1038/s43856-024-00596-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-23K14451
[Journal Article] Statistically and functionally fine-mapped blood eQTLs and pQTLs from 1,405 humans reveal distinct regulation patterns and disease relevance2024
- Author(s)
  Wang Qingbo S.、Hasegawa Takanori、Namkoong Ho、Saiki Ryunosuke、Edahiro Ryuya et al.
- Journal Title
  
  Nature Genetics
  
  Volume: 56 Issue: 10 Pages: 2054-2067
- DOI
  10.1038/s41588-024-01896-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-23K19564, KAKENHI-PROJECT-24K02004
[Journal Article] Body mass index stratification optimizes polygenic prediction of type 2 diabetes in cross-biobank analyses2024
- Author(s)
  Ojima Takafumi、Namba Shinichi、Suzuki Ken、Yamamoto Kenichi、Sonehara Kyuto、Narita Akira、the Tohoku Medical Megabank Project Study Group、the Biobank Japan Project、Kamatani Yoichiro、Tamiya Gen、Yamamoto Masayuki、Yamauchi Toshimasa、Kadowaki Takashi、Okada Yukinori
- Journal Title
  
  Nature Genetics
  
  Volume: 56 Issue: 6 Pages: 1100-1109
- DOI
  10.1038/s41588-024-01782-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-24K13523
[Journal Article] Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases2024
- Author(s)
  Tian Chi、Zhang Yuntian、Tong Yihan、Kock Kian Hong、Sim Donald Yuhui、Liu Fei、Dong Jiaqi、Jing Zhixuan、Wang Wenjing、Gao Junbin、....、Ishigaki Kazuyoshi、Okamura Tomohisa、Fujio Keishi、Okada Yukinori、Park Woong-Yang、Shin Jay W.、Roca Xavier、Prabhakar Shyam、Liu Boxiang
- Journal Title
  
  Nature Genetics
  
  Volume: 56 Issue: 12 Pages: 2739-2752
- DOI
  10.1038/s41588-024-02019-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24373, KAKENHI-PROJECT-23K14451
[Journal Article] Genome-wide association study on meningioma risk in Japan: a multicenter prospective study2024
- Author(s)
  Yamada Shuhei、Umehara Toru、Sonehara Kyuto、Kijima Noriyuki、Kawabata Shuhei、Takano Koji、Kidani Tomoki、Hirayama Ryuichi、Arita Hideyuki、Okita Yoshiko、Kinoshita Manabu、Kagawa Naoki、Fujinaka Toshiyuki、Fujita Toshiaki、Wakayama Akatsuki、Biobank Japan Project、Matsuda Koichi、Okada Yukinori、Kishima Haruhiko
- Journal Title
  
  Journal of Neuro-Oncology
  
  Volume: 169 Issue: 2 Pages: 281-286
- DOI
  10.1007/s11060-024-04727-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09200, KAKENHI-PROJECT-19K18426, KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-22K07279, KAKENHI-PROJECT-22K09283
[Journal Article] Bioactive Mediator Profile of Mepolizumab‐Treated Eosinophilic Granulomatosis With Polyangiitis2024
- Author(s)
  Kamide Yosuke、Sonehara Kyuto、Sekiya Kiyoshi、Ueki Shigeharu、Nakamura Yuto、Okada Yukinori、Taniguchi Masami
- Journal Title
  
  Allergy
  
  Volume: 80 Issue: 3 Pages: 882-885
- DOI
  10.1111/all.16395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-24K11593
[Journal Article] Genetic legacy of ancient hunter-gatherer Jomon in Japanese populations2024
- Author(s)
  Yamamoto Kenichi,,,Gakuhari Takashi,,,Nakagome Shigeki, Okada Yukinori
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 1-15
- DOI
  10.1038/s41467-024-54052-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05822, KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-23K23974, KAKENHI-PROJECT-23K14451
[Journal Article] Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues2024
- Author(s)
  Tomofuji Yoshihiko、Edahiro Ryuya、Sonehara Kyuto、Shirai Yuya、Kock Kian Hong、et al.
- Journal Title
  
  Cell Genomics
  
  Volume: 4 Issue: 8 Pages: 100625-100625
- DOI
  10.1016/j.xgen.2024.100625
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-23K27671, KAKENHI-PROJECT-24K12174, KAKENHI-PROJECT-24K12195
[Journal Article] Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity2023
- Author(s)
  Japan COVID-19 Task Force
- Journal Title
  
  Nature Genetics
  
  Volume: 55 Issue: 5 Pages: 753-767
- DOI
  10.1038/s41588-023-01375-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16624, KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-22K08283, KAKENHI-PROJECT-23K11300, KAKENHI-PROJECT-21K09068, KAKENHI-PROJECT-22K15493, KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-23K27671
[Journal Article] Extracting immunological and clinical heterogeneity across autoimmune rheumatic diseases by cohort-wide immunophenotyping2023
- Author(s)
  Tanaka Hiroaki、Okada Yukinori、Nakayamada Shingo、Miyazaki Yusuke、Sonehara Kyuto et al.
- Journal Title
  
  Annals of the Rheumatic Diseases
  
  Volume: 83 Issue: 2 Pages: 242-252
- DOI
  10.1136/ard-2023-224537
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-23K24465, KAKENHI-PROJECT-24K11609
[Journal Article] Reconstruction of the personal information from human genome reads in gut metagenome sequencing data2023
- Author(s)
  Tomofuji Yoshihiko、Sonehara Kyuto et al.
- Journal Title
  
  Nature Microbiology
  
  Volume: 8 Issue: 6 Pages: 1079-1094
- DOI
  10.1038/s41564-023-01381-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-22H00476
[Journal Article] Analysis of gut microbiome, host genetics, and plasma metabolites reveals gut microbiome-host interactions in the Japanese population2023
- Author(s)
  Tomofuji Yoshihiko、Kishikawa Toshihiro、Sonehara Kyuto et al.
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 11 Pages: 113324-113324
- DOI
  10.1016/j.celrep.2023.113324
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-21K08344, KAKENHI-PROJECT-22H00476
[Journal Article] Genome-wide association study identifies risk loci within the major histocompatibility complex region for Hunner-type interstitial cystitis2023
- Author(s)
  Akiyama Y、Sonehara K、Maeda D、Katoh H、Naito T、Yamamoto K、Morisaki T、Ishikawa S、Ushiku T、Kume H、Homma Y、Okada Y
- Journal Title
  
  Cell Reports Medicine
  
  Volume: 4 Issue: 7 Pages: 101114-101114
- DOI
  10.1016/j.xcrm.2023.101114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16788, KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-22K07538, KAKENHI-PROJECT-22H00476
[Journal Article] Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis2023
- Author(s)
  Sato Go、Shirai Yuya、Namba Shinichi、Edahiro Ryuya、Sonehara Kyuto et al.
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 3671-3671
- DOI
  10.1038/s41467-023-39136-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-22K07538, KAKENHI-PROJECT-23K08128, KAKENHI-PROJECT-22H00476
[Journal Article] Estimating gene-level false discovery probability improves eQTL statistical fine-mapping precision2023
- Author(s)
  Wang Qingbo S、Edahiro Ryuya、Namkoong Ho、Hasegawa Takanori、Shirai Yuya、Sonehara Kyuto et al.
- Journal Title
  
  NAR Genomics and Bioinformatics
  
  Volume: 5 Issue: 4
- DOI
  10.1093/nargab/lqad090
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14451
[Presentation] 頭蓋内胚細胞腫瘍のゲノムワイド関連解析は遺伝的背景の解明を通じ、病因と疫学の理解に貢献する2023
- Author(s)
  曽根原究人, 木村由依, 中野嘉子, 小澤達也, 藤井隆司, 富山新太, 鈴木智成, 山口秀, 三輪点, 大江直行, 深井順也, 河村淳史, 市村幸一, 西川亮, 岡田随象, 寺島慶太
- Organizer
  第82回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K14451
[Presentation] Genome-wide association and HLA fine-mapping analysis of Hunner-type interstitial cystitis identify risk HLA variants.2023
- Author(s)
  Kyuto Sonehara, Yoshiyuki Akiyama, Daichi Maeda, Hiroto Katoh, Tatsuhiko Naito, Kenichi Yamamoto, Biobank Japan Project, Takayuki Morisaki, Shumpei Ishikawa, Tetsuo Ushiku, Haruki Kume, Yukio Homma, Yukinori Okada
- Organizer
  Human Genetics Asia 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14451
[Presentation] Genome-wide association and HLA fine-mapping analysis of Hunner-type interstitial cystitis identify predisposing class II HLA variants.2023
- Author(s)
  Kyuto Sonehara, Yoshiyuki Akiyama, Daichi Maeda, Hiroto Katoh, Tatsuhiko Naito, Kenichi Yamamoto, Biobank Japan Project, Takayuki Morisaki, Shumpei Ishikawa, Tetsuo Ushiku, Haruki Kume, Yukio Homma, Yukinori Okada
- Organizer
  The 14th International Workshop on Advanced Genomics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14451
[Presentation] Genome-wide association and HLA fine-mapping analysis of Hunner-type interstitial cystitis identify predisposing class II HLA variants.2023
- Author(s)
  Kyuto Sonehara, Yoshiyuki Akiyama, Daichi Maeda, Hiroto Katoh, Tatsuhiko Naito, Kenichi Yamamoto, Biobank Japan Project, Takayuki Morisaki, Shumpei Ishikawa, Tetsuo Ushiku, Haruki Kume, Yukio Homma, Yukinori Okada
- Organizer
  The American Society of Human Genetics Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14451

1. 秋山佳之 (20529135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 前田大地 (30585500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 蔵野信 (60621745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 新美文彩 (00376451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 野里博和 (40435764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ISHIKAWA Taisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. KINOSHITA Manabu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. ARITA Hideyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 蒔田直昌

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 岡田随象

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 王青波

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 石垣和慶

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 覚張隆史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 中込滋樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sonehara Kyuto 曽根原 究人

Research Projects

Research Products

Co-Researchers

横断的オミクス解析と機械学習による間質性膀胱炎の治療標的とバイオマーカーの開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating structural diversity and functional significance of the MHC region using long-read sequencingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genome-wide elucidation of disease susceptibility structural variation using short- and long-read sequencingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Germline variants and mosaic chromosomal alterations affect COVID-19 vaccine immunogenicity2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Contribution of germline and somatic mutations to risk of neuromyelitis optica spectrum disorder2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A genome-wide meta-analysis reveals shared and population-specific variants for allergic sensitization2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Retrotrans-genomics identifies aberrant THE1B endogenous retrovirus fusion transcripts in the pathogenesis of sarcoidosis2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Incomplete human reference genomes can drive false sex biases and expose patient-identifying information in metagenomic data2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Blood DNA virome associates with autoimmune diseases and COVID-192025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic drivers of heterogeneity in type 2 diabetes pathophysiology2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Brugada syndrome in Japan and Europe: a genome-wide association study reveals shared genetic architecture and new risk loci2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Primary Aldosteronism and Risk of Cardiovascular Outcomes: Genome‐Wide Association and Mendelian Randomization Study2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Machine learning reveals heterogeneous associations between environmental factors and cardiometabolic diseases across polygenic risk scores2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Statistically and functionally fine-mapped blood eQTLs and pQTLs from 1,405 humans reveal distinct regulation patterns and disease relevance2024

Author(s)

Journal Title

Sonehara Kyuto 曽根原究人

[Presentation] 頭蓋内胚細胞腫瘍のゲノムワイド関連解析は遺伝的背景の解明を通じ、病因と疫学の理解に貢献する2023