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Osaki Tokio  尾崎 登喜雄

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OSAKI Tokio  尾崎 登喜雄

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Researcher Number 70031995
External Links
Affiliation (Current) 2025: 高知大学, その他部局等(名誉教授), 名誉教授
Affiliation (based on the past Project Information) *help 2012: 高知大学, その他部局等, 名誉教授
2007 – 2011: Kochi University, 名誉教授
2003: Kochi Medical School, Department of Oral Surgery, Professor, 医学部, 教授
1995 – 2002: 高知医科大学, 医学部, 教授
Review Section/Research Field
Principal Investigator
病態科学系歯学(含放射線系歯学) / Surgical dentistry / Surgical dentistry
Except Principal Investigator
病態科学系歯学(含放射線系歯学)
Keywords
Principal Investigator
p21 / p53 / Mn-SOD / 活性酸素 / CdK / 5-FU / 唾液 / アポトーシス / 放射線 / β-catenin … More / claudin / occludin / tight junction / reactive oxygen species / invasion / oral cancer / 活性酵素 / β-カテニン / クラウジン / オクルジン / タイトジャンクション / 浸潤 / 口腔癌 / reactive oxygen intermediates / macrophage / neutrophil / saliva / lactoferrin peptide / lactoferrin / candidiasis / ディフェンシン / NADPH / マクロファージ / 好中球 / ラクトフェリンペプタイド / ラクトフェリン / カンジダ症 / bcl-2 family / differentiation induction / apoptosis induction / cdk / bcl-2ファミリー / 分化誘導 / アポトーシス誘導 / cyclin-dependent kinase / gamma-rays / TGF-beta / apoptosis / squamous cell carcinoma cells / 扁平上皮癌 / サイクリン依存キナーゼ / TGF-β / 扁平上皮癌細胞 / MIC / Genotype / Phenotype / 抗真菌剤 / 口腔カンジダ菌 / 病原性 / カンジダ / 抗菌ペプチド / 病原因子 / 口腔カンジダ症 / Tfam / POLG / OGG1 / DNA損傷修復 / 相同組み換え / 17-AAG / Rad51 / DNA損傷 / 口腔扁平上皮癌 … More
Except Principal Investigator
Mn-SOD / Peptide 2 / 活性酸素 / cytokine / CD59 / サイトカイン / neutrophils / aspergillosis / candidiasis / cytochrome P450 / β-defensin / α-defensin / antimicrobial peptide / カンジタ症 / チトクロームp450 / Peptide2 / 好中球 / アスペルギルス症 / カンジダ症 / チトクロームP450 / β-ディフェンシン / α-ディフェンシン / 抗菌ペプタイド / cytotoxic activity / lymphocyte subpopulation / reactive oxygen species / surface antigens / intranodal injection / peplomycin / ミトコンドリア / AIF / チトクロームC / Fas L / Fas / FGF-2 / IFN-γ / IL-2 / T細胞 / 細胞傷害能 / リンパ球亜集団 / 細胞傷害活性 / リンパ球亜群 / 表面抗原 / リンパ節内注入 / ペプロマイシン / LAK cells / HィイD22ィエD2OィイD22ィエD2 / reactive oxygen intermediates / apoptosis / squamous cell carcinoma cells / LAK細胞 / H_2O_2 / アポトーシス / 扁平上皮癌細胞 / lipopolysaccharide (LPS) / nuclear factor (NF)-_KB / mononulcear leukocytes / beta_1 and beta_2 integrins / keratinocytes / oral lichen planus / 細胞内シグナル伝達 / チロシンリン酸化 / 接着因子 / migration / LPS / NF-KB / 単核球 / β_1およびβ_2インテグリン / ケラチノサイト / 口腔扁平苔癬 Less
  • Research Projects

    (10 results)
  • Research Products

    (8 results)
  • Co-Researchers

    (14 People)
  •  Investigation of factors involved in the acquisition of pathogenicity of oral Candida species and their control by anti-microbial peptidesPrincipal Investigator

    • Principal Investigator
      OSAKI Tokio
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Kochi University
  •  Development of novel treatment for oral cancer due to analysis of DNA repair systemPrincipal Investigator

    • Principal Investigator
      OSAKI Tokio
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Kochi University
  •  Biological investigation of antimicrobial peptides for the regulation of fungal infections

    • Principal Investigator
      UETA Eisaku
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      Kochi Medical School
  •  Basic investigation on moledules which regulate the sensitivity of oral squamous cell carcinoma (cells) to chemo-radio-immunotherapyPrincipal Investigator

    • Principal Investigator
      OSAKI Tokio
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Kochi Medical School
  •  BIOFILM OF ORAL CANDIDA AND BIOLOGICAL INVESTIGATION ON CANDIDA-REGULATING FACTORS IN SALIVAPrincipal Investigator

    • Principal Investigator
      OSAKI Tokio
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      Kochi Medical school
  •  GROWTH OF METASTATIC CACNER CELLS IN THE LYMPH NODES AND ITS REGULATION BY LYMPHOCYTES

    • Principal Investigator
      YAMAMOTO Tetsuya
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      高知医科大学
  •  CLINICAL AND BASIC INVESTIGATION ON APOPTOSIS OF HEAD AND NECK CARCINOMAS BY MULTIDISCIPLINARY TREATMENTSPrincipal Investigator

    • Principal Investigator
      OSAKI Tokio
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      Kochi Medical School
  •  THE ROLE OF REACTIVE OXYGEN INTERMEDIATES AND THEIR SCAVENGERS ON APOPTOSIS INDUCTION OF SQUAMOUS CELL CARClNOMA CELLS

    • Principal Investigator
      YONEDA Kazunori
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      Kochi Medical School
  •  Intracellular Signal Transduction in Oral Keratinocytes and Infiltrated Lymphocytes Obtained from Patients with Oral Lichen Planus-Biochemical Analysis of the Mechanism of Enhanced Cytokine Generation from Keratinocytes and Infiltration of Lymphocytes

    • Principal Investigator
      YAMAMOTO Tetsuya
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      Kochi Medical School
  •  THE MECHANISM OF DIFFERENTIATION IN SQUAMOUS CELL CARCINOMA CELLS AND INDUCTION OF APOPTOSIS IN HEAD AND NECK CARCINOMASPrincipal Investigator

    • Principal Investigator
      OSAKI Tokio
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Kochi Medical School

All 2011 2008 2007

All Journal Article Presentation Book

  • [Book] 口腔内科学2008

    • Author(s)
      尾崎登喜雄
    • Total Pages
      462
    • Publisher
      株式会社飛鳥出版室
    • Data Source
      KAKENHI-PROJECT-19592300
  • [Journal Article] Enhancement of apoptotic damage of squamous cell carcinoma cells by inhibition of the mitochondrial DNA repairing system2008

    • Author(s)
      Eisaku Ueta, Eri Sasabe, Zhu Yang, Tokio Osaki, Tetsuya Yamamoto
    • Journal Title

      Cancer Science 99

      Pages: 2230-2237

    • NAID

      10024013145

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592300
  • [Journal Article] Enhancement of apoptotic damage of squamous cell carcinoma. cells by inhibition of the mitochondria] DNA repairinlg system.2008

    • Author(s)
      Ueta E, Sasabe F, Yang Z, Osaki T, Yamamoto T
    • Journal Title

      Cancer Sci 99

      Pages: 2230-2237

    • Data Source
      KAKENHI-PROJECT-19592300
  • [Journal Article] The endogenous reactive oxygen species promote NF-KB activation by targeting on activation of NF-kB-inducing kinase in oral squamous carcinoma cell2007

    • Author(s)
      Wang Y, Huang X, Cang H, Gao F, Ymamoto T, Osaki T, Yi J
    • Journal Title

      Free Radic Res 41(9)

      Pages: 963-971

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592300
  • [Journal Article] The involvement of hypoxia-inducible factor-1αin the susceptibility toγ-rays and chemotherapeutic drugs of oral squamous cell carcinoma cells.2007

    • Author(s)
      Sasabe E, Zhou X, Li D, Oku N, Yamamoto T, Osaki T
    • Journal Title

      Int J Cancer 120(2)

      Pages: 268-77

    • Data Source
      KAKENHI-PROJECT-19592300
  • [Journal Article] EGCG-targeted p57/KTP2 reduces tumorigenicity of oral carcinoma. cells: Role of c-Jun N-terminal kinase.2007

    • Author(s)
      Yamamoto T, Digumarthi H, Aranbayeva. Z, Wataha J, Lewis j, Messer R, Qin H, Dickinson D, Osaki T, Schuster GS, Hsu S
    • Journal Title

      Toxicol Appl Pharmacol 224(3)

      Pages: 318-325

    • Data Source
      KAKENHI-PROJECT-19592300
  • [Journal Article] The endogenous reactive oxygen species promote NF-KB activation by targeting on activation of NF-KB-inducing kinase in oral squamous carcinoma cells.2007

    • Author(s)
      Yumei Wang, Xinzhi Huang, Hui Cang, Fei Gao, Tetsuya Yamamoto, Tokio Osaki, jing Yi
    • Journal Title

      Free Radical Research 41(9)

      Pages: 963-971

    • Data Source
      KAKENHI-PROJECT-19592300
  • [Presentation] Repetitive-sequence-based PCR法を用いた口腔カンジダ菌のGenotypingに関する検討2011

    • Author(s)
      森下慶子、成川玄、尾崎登喜雄、山本哲也
    • Organizer
      第3回高知口腔科学研究会
    • Place of Presentation
      高知医療センター・黒潮ホール、高知市
    • Year and Date
      2011-05-15
    • Data Source
      KAKENHI-PROJECT-22592217
  • 1.  YAMAMOTO Tetsuya (00200824)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 6 results
  • 2.  UETA Eisaku (10203431)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 2 results
  • 3.  KIMURA Tsuyoshi (10294836)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  YONEDA Kazunori (90182849)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  KAMATANI Takaaki (00315003)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  SASABE Eri (40363288)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 7.  SATAKE Hidetaka (10304685)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  OKU Naohisa (20363286)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  TATEISHI Yoshihisa (20372732)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  SUGIHARA Kazumasa (00117516)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KAMIKAWA Yoshiaki (30332901)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  MORISHITA Keiko (10527584)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 13.  KITAMURA Naoya (70351921)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  OHNO Seiji (40624995)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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