RIKIISHI Hidemi 力石秀実

… Alternative Names

力石秀美リキイシヒデミ

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Researcher Number	70091767
External Links
Affiliation (based on the past Project Information) *help	2007 – 2009: 東北大学, 大学院・歯学研究科, 准教授 2006: Tohoku University, Graduate School of Dentistry, Associate Professor, 大学院歯学研究科, 助教授 2005: 東北大学, 大学院・歯学研究科, 助教授 2000 – 2004: 東北大学, 大学院・歯学研究科, 講師 2003: Tohoku Univ., Graduate Sch.Dent., Assistant Prof., 大学院・医学系研究科, 講師 … More 1997 – 1999: Tohoku University, School of Dentistry, Department of Microbiology and Immunolog, 歯学部, 講師 1990 – 1996: 東北大学, 歯学部, 助手 1986: 東北大学, 歯学部, 助手 Less
Review Section/Research Field	Principal Investigator Morphological basic dentistry / Surgical dentistry / Functional basic dentistry Except Principal Investigator Morphological basic dentistry / Digestive surgery / Immunology / Surgical dentistry
Keywords	Principal Investigator CD80 / Fas / Apoptosis / LPS / アポトーシス / カスパーゼ / Superantigen / スーパー抗原 / サイトカイン / NF-κB … More / FasL / Fas L / Lipopolysaccharide / 内毒素 / Reactive oxygen species / Cytochrome C / Mitochondria / Caspase / Cisplatin / Selenium compounds / Taxotere / 膜電位 / 増強剤 / グルタチオン / epigenetics / 併用療法 / 活性酸素 / チトクロームC / ミトコンドリア / シスプラチン / セレニウム化合物 / タキソテール / Cytokine / Gingival tissue / 歯周組織 / Monocyte / インターフェロンγ / 単球 / Periodontal disease / 歯周病 / Arthropathic reaction / GM-CSF / Cytoplasmic membrane protein / Peptidoglycan / 急性関節炎 / マウス系統差 / ペプチドグリカン刺激 / 炎症反応 / GMーCSF / 細菌細胞質膜タンパク質 / ペプチドグリカン / DNAメチル化酵素 / ヒストン脱アセチル化酵素 / エピジェネティクス / 血行性転移 / 口腔癌 … More Except Principal Investigator ICAM-1 / SPM / Streptococcus pyogenes / Streptococcus mitis / IL-6 / MRL / 接着分子 / サイトカイン / 臓器特異的転移 / activation mechanism / adhesion molecules / cytokines / human gingival epithelial cells / black-pigmented bacteria / 活性化機構 / 歯肉上皮細胞 / 黒色色素産生菌 / T cells / epithelial cells / superantigen / Oral streptococci / UFA-1 / 口腔粘膜 / Streptococons mitis / ビリダンスレンサ球菌 / CPA / SEB / S.pyogenes / 口腔粘膜疾患 / T細胞 / 上皮細胞 / スーパー抗原 / 口腔レンサ球菌 / NK cells / Immunotherapy / Cytotoxic cells / CD3^+CD56^+ cells / TNK cells / NK1^+TCR^<int> cells / Interleukin 12 / 転移抑制効果 / マウス実験転移モデル / 肝NK細胞 / 細胞障害活性 / NK細胞 / 抗癌免疫療法 / 細胞傷害活性 / CD3 CD56細胞 / TNK細胞 / CD3 intermediate T細胞 / インターロイキン12 / Autoimmune disease / Liver / 1pr mice / lprマウス / MRL-lpr / MRL-1prマウス / 自己免疫疾患 / 肝臓 / 1prマウス / 腫瘍免疫 / ヘルパーT細胞 / Ia抗原 / インターフェロンγ / インターロイキン4 / 自己リンパ球混合培養 / インターロイキン3 / 活性酸素 / ミトコンドリア / G1期 / G0 / 細胞周期 / NaB / HDAC阻害剤 / ヒストン脱アセチル化酵素阻害剤 / 抗癌剤併用 / 薬剤感受性増強 / アポトーシス / SAHA / ZEB / エピジェネティクス制御 / 口腔癌 / 小胞体 / エピジェネテイクス / 5-FU / CDDP / p53 / 口腔外科学一般(含病態検査学) / 遺伝子導入 / CD44分子 / GM-CSF / 腫瘍 / 胸腺外分化 / αβT細胞 / γδT細胞 / 肝類洞 / 担癌 Less

口腔癌の血行性転移メカニズムにおけるエピジェネティクス制御の解析Principal Investigator
- Principal Investigator
  
  力石秀実
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Tohoku University
Augmentation of apoptosis in OSCC using oncogene therapy
- Principal Investigator
  
  ECHIGO Seishi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Tohoku University
Mechanisms of Taxotere-induced apoptosis in or a squamous cell carcinoma.Principal Investigator
- Principal Investigator
  
  RIKIISHI Hidemi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  TOHOKU UNIVERSITY
Selective apoptosis during treatment with superantigen and lipopolysaccharidePrincipal Investigator
- Principal Investigator
  
  RIKIISHI Hidemi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  TOHOKU UNIVERSITY
Inhibition of superantigen-induced apoptosis by LPSPrincipal Investigator
- Principal Investigator
  
  RIKIISHI Hidemi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  TOHOKU UNIVERSITY
The etiological significance of superantigen in periodontal disease and its possible rolePrincipal Investigator
- Principal Investigator
  
  RIKIISHI Hidemi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  TOHOKU UNIVERSITY
Activation of human gingival epithelial cells by black-pigmented bacteria
- Principal Investigator
  
  SUGAWARA Shunji
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tohoku University
Superantigen Produced by oral Streptococci and oral mucosal diseases.
- Principal Investigator
  
  TAKADA Haruhiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tohoku University
Basic study on anti-cancer immunotherapy using interleukin 12
- Principal Investigator
  
  SHIIBA Ken-ichi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Unusual increase of extrathymic T cells in the liver of autoimmune MRL-1pr/1pr mice.
- Principal Investigator
  
  KUMAGAI Katsuo
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  TOHOKU UNIVERSITY
臓器特異的癌転移機構に関する研究:サイトカインと接着因子の役割
- Principal Investigator
  
  熊谷勝男
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
癌転移における癌細胞サイトカイン産生の役割
- Principal Investigator
  
  KUMAGAI Katsuo
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
Induction of cytokines by oral bacterial stimulation and its arthropathic propertiesPrincipal Investigator
- Principal Investigator
  
  RIKIISHI Hidemi
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tohoku University
担癌生体の肝類洞に見られるTcRγδ細胞の増殖とその活性化機構
- Principal Investigator
  
  安保徹
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
リンホカインによるキラーリンパ球の誘導機構に関する研究
- Principal Investigator
  
  熊谷勝男
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Tohoku University

All 2009 2008 2007 2005 2004

All Journal Article Presentation

[Journal Article] Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells2009
- Author(s)
  Suzuki M, Endo M, Shinohara F, Echigo S and Rikiishi H
- Journal Title
  
  Cancer Chemo. Pharma(Online Pub.)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390532
[Journal Article] Zebularine suppresses the apoptotic potential of 5-fluorouracil via cAMP/PKA/CREB pathway against human oral squamous cell carcinoma cells2008
- Author(s)
  Suzuki M, Shinohara F, Endo M, Sugazaki M, Echigo S and Rikiishi H
- Journal Title
  
  Cancer Chemo. Pharma.(Online Pub.)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390532
[Journal Article] Epigeneteic regulation of susceptibility to anti-cancer drugs in HSC-3 cells2007
- Author(s)
  Suzuki M, Shinohara F, Nishimura K, Sato Y, Echigo S and Rikiishi H
- Journal Title
  
  Interface Oral Health Science
  
  Pages: 279-280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390532
[Journal Article] Chemosensitization of oral squamous cell carcinoma cells to cisplatin by histone deacetylase inhibitor, Suberoylanilide hydroxamic acid.2007
- Author(s)
  Rikiishi H, Shinohara F, Sato T, Sato Y, Suzuki M and Echigo S
- Journal Title
  
  Int.J.Oncology 30
  
  Pages: 1181-1188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390532
[Journal Article] Epigenetic regulation of chemosensitivity to 5-fluorouracil and cisplatin by zebularine in oral squamous cell carcinoma2007
- Author(s)
  Suzuki M, Shinohara F, Nishimura K, Echigo S and Rikiishi H
- Journal Title
  
  Int.J.Oncology 31
  
  Pages: 1449-1456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390532
[Journal Article] Epigenetic regulation of chemosennsitivity to 5-fluorouracil and cisplatin by zebularine in oral squamous cell carcinoma2007
- Author(s)
  Suzuki M, Rikiishi H、 Echigo S, et. al.
- Journal Title
  
  Int J Oncol 31(6)
  
  Pages: 1449-1456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390532
[Journal Article] Chemosensitization of oral squamous cell carcinoma cells to cislatin By histone deacetylase inhibitor, suberoylanilide hydroxamic acid2007
- Author(s)
  Rikiishi H, Echigo S, et al.
- Journal Title
  
  Int J Oncol 30・5
  
  Pages: 1181-1188
- Data Source
  KAKENHI-PROJECT-18390532
[Journal Article] シスプラチン化学療法における新展開2005
- Author(s)
  力石秀実
- Journal Title
  
  東北大学歯学雑誌 24(1)
  
  Pages: 1-15
- NAID
  110004616114
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390577
[Journal Article] New developments in cisplatin chemotherapy for cancer.2005
- Author(s)
  H.Rikiishi
- Journal Title
  
  Tohoku University Dental Journal 24(1)
  
  Pages: 1-15
- NAID
  110004616114
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390577
[Journal Article] A possible mitochondrial pathway taxane-induced apoptosis.2004
- Author(s)
  H.Rikiishi et al.
- Journal Title
  
  Current Trends Immunology 6
  
  Pages: 97-110
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390577
[Journal Article] A possible mitochondrial pathway in taxane-induced apoptosis.2004
- Author(s)
  H.Rikiishi
- Journal Title
  
  Current Trends Immunology 6
  
  Pages: 97-110
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390577
[Presentation] Effects of Zebularine on the apoptosis of 5-Fluorouracil via cAMP/PKA/CREB pathway against human oral squamous cell carcinoma cells.2009
- Author(s)
  Maiko Suzuki, Fumiaki Shinohara, Manabu Endo, Masaki Sugazaki, Seishi Echigo and Hidemi Rikiishi
- Organizer
  The 3^<rd> International Symposium for interface Oral Health Science
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-18390532
[Presentation] 口腔癌のVEGF産生とエピジェネティクス制御2008
- Author(s)
  鈴木麻衣子、篠原文明、菅崎将樹、越後成志、力石秀実
- Organizer
  第5回東北大学バイオサイエンスシンポジウム
- Place of Presentation
  仙台
- Year and Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-18390532
[Presentation] 口腔癌の血管新生とエピジェネティクス制御2008
- Author(s)
  鈴木麻衣子、篠原文明、遠藤学、菅崎将樹、越後成志、力石秀実
- Organizer
  第50回歯科基礎医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390532
[Presentation] エピジェネティクス制御剤による血管新生の抑制2008
- Author(s)
  遠藤学、鈴木麻衣子、篠原文明、菅崎将樹、越後成志、力石秀実
- Organizer
  日本細菌学会東北支部総会
- Place of Presentation
  十和田
- Data Source
  KAKENHI-PROJECT-18390532
[Presentation] エピジェネティクス制御化合物と抗癌剤の併用による口腔癌のアポトーシス誘導効果2007
- Author(s)
  鈴木(麻)、篠原、越後、力石.
- Organizer
  第49回歯科基礎医学会
- Place of Presentation
  札幌
- Year and Date
  2007-08-30
- Data Source
  KAKENHI-PROJECT-18390532

1. KUMAGAI Katsuo (00005018)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. HANAUMI Kiyoshi (50005063)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. SUGAWARA Shunji (10241639)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. 清水義信 (20005078)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. ECHIGO Seishi (70005114)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
6. TAKADA Haruhiko (30135743)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 安保徹 (30005079)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SUGIYAMA Akiko

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. SHIIBA Ken-ichi (90196345)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ANZAI Ryoishi (50260427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ISHII Seiichi (60221066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. AKITA Hirotoshi (10108540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HASHIMOTO Wataru (30323033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 増田高行 (00113910)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 樗木俊聡 (50233200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 鈴木麻衣子 (70420049)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

RIKIISHI Hidemi 力石 秀実

力石 秀美 リキイシ ヒデミ

Research Projects

Research Products

Co-Researchers

口腔癌の血行性転移メカニズムにおけるエピジェネティクス制御の解析Principal Investigator

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Mechanisms of Taxotere-induced apoptosis in or a squamous cell carcinoma.Principal Investigator

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Research Category

Research Field

Research Institution

Selective apoptosis during treatment with superantigen and lipopolysaccharidePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

Inhibition of superantigen-induced apoptosis by LPSPrincipal Investigator

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The etiological significance of superantigen in periodontal disease and its possible rolePrincipal Investigator

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Induction of cytokines by oral bacterial stimulation and its arthropathic propertiesPrincipal Investigator

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RIKIISHI Hidemi 力石秀実

力石秀美リキイシヒデミ