HOSAKA Kohei 保坂公平

… Alternative Names

保坂公平ホサカコウヘイ

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Researcher Number	70108992
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2016: 高崎健康福祉大学, 大学院健康福祉学研究科, 講師 2014 – 2015: 高崎健康福祉大学, その他の研究科, 講師 2010: 群馬大学, 医学研究科, 教授 2003 – 2008: 群馬大学, 医学部, 教授 1997 – 2001: 群馬大学, 医学部, 教授 1994 – 1995: Gunma University, Department of Biochemistry, Associate Professor, 医学部, 助教授 1989 – 1993: 群馬大学, 医学部, 講師
Review Section/Research Field	Principal Investigator General medical chemistry / Structural biochemistry / Functional biochemistry / Biological pharmacy / Medical pharmacy Except Principal Investigator Medical pharmacy / Endocrinology / Cerebral neurosurgery / Risk sciences of radiation and chemicals / 代謝生物化学 / General medical chemistry / Pathological medical chemistry / 寄生虫学(含医用動物学)
Keywords	Principal Investigator DIF-1 / 酵母 / コリン / リン脂質 / mRNA / 細胞性粘菌 / 分化誘導因子 / 白血病細胞 / cellular slime mold / leukemia cells … More / 脂質 / イノシトール / 発現調節 / スファチジルイノシトール / リン脂質輸送蛋白質 / イン・サイトハイブリダイゼーション / 脳 / ホスファチジルコリン / リン脂質合成 / メチル化酵素 / ベクタ- / イノシト-ル / 共通配列 / 酵母内発現ベクタ- / 分裂酵母 / ホスファテジルコリン / コリンキナ-ゼ / Phosphatidylcholine / Phospholipid-synthesis / methyltransferase / vector / yeast / inositol / choline / common-sequence / イン・サイトバイブリダイゼーション / m RNA / ホスファテジルイノシトール合成酸素 / 脳内分布 / 細胞周期 / 阻害剤 / サイクリン D / サイクリン E / ラット / ホスファチジルイノシトール / ホスファチジルイノシトール合成酵素 / G1期 / サイクリンD / サイクリンE / インサイトハイブリダゼイーション / 海馬 / in situ hybridization / phosphatidylinositol synthase / distribution in brain / cell cycle / inhibitor / cyclinD / cyclinE / カルシウム / カルシニューリン / 抗腫瘍因子 / アポトーシス / インシュリン / Insulinoma細胞 / カスパーゼ / 抗ウイルス作用 / 抗腫瘍作用 / DIF / Xenopus laevis / 卵母細胞 / cAMP / Jarkat細胞 / Jac / Statシグナル伝達 / protein kinaseB / differentiation inducing factor / calcium / calcineurin / anti-tumor factor / apotosis / DIF-1様因子 / 増殖阻害活性 / 薬理学的ターゲット / dictyopyrones / DIF様因子 / 増殖抑制 / Dictiostelium mucoroides / 4-methyl-5-n-propylbenzene-1,3-diol / キノコ / ハロゲン化化合物 / differentiation-inducing factor / DIF-1 like factors / growth inhibitory activity / pharmacological specific target / Dictyopyrones … More Except Principal Investigator Dictyostelium / PDE1 / ホスファチジルコリン代謝 / コリンキナ-ゼ / 酵素精製 / ホスホリパーゼD / リゾホスホリパーゼ / ホスファチジン酸 / DIF / 転写因子 / ras / ホスホリパ-ゼC / 細胞性粘菌 / がん / プロモ-タ- / 遺伝子発現 / phospholipase D / lysophospholipase / phosphatidic acid / enzyme purification / gene expression / ゴナドトロピン / transcription factor / inducible gene / NADH / Rag2- / DIF-1 / 抗腫瘍因子 / Erk / K562 / cDNA / ホスファチジルコリン / 情報伝達 / ジメチルベンシアントラセン / 乳癌 / 分化誘導因子 / 糖尿病 / 肥満 / 抗腫瘍剤 / 糖代謝 / 低分子化合物 / 脳梗塞 / 白質障害 / 病態解析 / 質量顕微鏡 / 軸索再生 / 細胞移植治療 / ラット白質梗塞モデル / 血管内皮細胞 / 虚血細胞死 / 細胞移植 / カルシニューリン / アルキルベンゼンスルホン酸 / インターロイキン-2 / 非競合阻害 / 阻害物質 / リン脂質合成 / 遺伝子クロ-ニング / ホスファチジルエタノ-ルアミンメチル化経路 / Phospholipid synthesis / Gene cloning / Promoter / Phosphatidylethanolamine methylation pathway / Choline kinase / 活性化 / 阻害 / 酵母リン脂質生合成 / イノシト-ル・コリン調節 / activation / inhibition / yeast phospholipid synthesis / 細胞増殖 / シグナル伝達 / リゾホスファチジルコリン / リゾホスファチジルコン / コリンキナーゼ / phosphatidylcholine metabolism / cell growth / signal transduction / lysophosphatidylcholine / 誘導性 / 卵巣顆粒膜細胞 / 卵胞発育 / gonadotropin / 卵巣 / ヒトホモローグ / ホルモン誘導性 / 腫瘍 / 遺伝子診断 / ovary / human homologue / 生ワクチン / 弱毒化原虫 / 2次元電気泳動 / プロテオーム解析 / - / 細胞移入 / 免疫記憶 / マラリア / Plasmodium berghei / 弱毒化 / プロテオソーム / 二次元電気泳動 / 原虫 / タンパク質 / ワクチン / HGPRT / 遺伝子導入 / hypoxanthine-guanine phosphoribosyltransferase(HGPRT) / live type malaria vaccine / attenuated parasites / two dementional electrophoresis / proteome analysis / -mice / cell transfer / immunological memory / 癌 / Anti-tumor drug / Cancer / 亜鉛 / anti-tumor agent / Zinc Less

Basic study on the cellular immunity of alkylbenzene sulfonate as an environmental pollutant
- Principal Investigator
  
  TANAKA Susumu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Takasaki University of Health and Welfare
Basic research for the comprehensive analysis of selective whitematter injury and the axonal regeneration
- Principal Investigator
  
  IMAI Hideaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  The University of Tokyo
Analysis of the mechanisms of the actions of DIF, a bio-active compound isolated from a soil micro-organism, and development of effective DIF derivatives
- Principal Investigator
  
  KUBOHARA Yuzuru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Gunma University
Analysis of the mechanisms of the actions of DIF-1 and its derivatives, anti-tumor agents isolated from Dictyostelium
- Principal Investigator
  
  KUBOHARA Yuzuru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Gunma University
Search for novel anti-tumor drugs and study on the action mechanismPrincipal Investigator
- Principal Investigator
  
  HOSAKA Kohei
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Gunma University
Analysis of the actions and the action mechanism of DIF, an anti-tumor agent isolated from a soil microorganism
- Principal Investigator
  
  KUBOHARA Yuzuru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Gunma University
Studies on a live type malaria vaccine. Molecular genetics of the parasite attenuation.
- Principal Investigator
  
  SUZUKI Mamoru
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  寄生虫学(含医用動物学)
- Research Institution
  Gunma University
Identification of receptor of anti-tumor factor DIF and development of new DIF-analogsPrincipal Investigator
- Principal Investigator
  
  HOSAKA Kohei
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gunma University
Research on the role of a new hormone-inducible transcription factor GIOT for the ovarian function.
- Principal Investigator
  
  MIYAMOTO Kaoru
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Endocrinology
- Research Institution
  Fukui Medical University
  Gunma University
Applied research for the development of gene diagnosis of ovarian dysfunction using a novel ovarian transcription factor GIOT.
- Principal Investigator
  
  MIYAMOTO Kaoru
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Endocrinology
- Research Institution
  Fukui Medical University
  Gunma University
Study on the tissue specific expression of phosphatidylinositol synthase and its function.Principal Investigator
- Principal Investigator
  
  HOSAKA Kohei
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Gunma University
2種類のホスファチジルイノシトール輸送蛋白質の発現調節と機能の解析Principal Investigator
- Principal Investigator
  
  保坂公平
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Gunma University
酵母の脂質合成関連遺伝子群のイノシトールとコリンによる発現調節の分子生物学的解析Principal Investigator
- Principal Investigator
  
  保坂公平
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Gunma University
STIMULATION AND DISORDER OF PHOSPHATIDYLCHOLINE METABOLISM CELL GROWTH
- Principal Investigator
  
  YAMASHITA Satoshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Gunma University
yas産物p21によるホスファチジルコリン代謝回転の促進とその分子機構
- Principal Investigator
  
  山下哲
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Gunma University
rasタンパク質によるホスファチジルコリン代謝の調節
- Principal Investigator
  
  YAMASHITA Satoshi
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Gunma University
Structure and expression of genes encoding the enzymes of phosphatidylcholine metabolism
- Principal Investigator
  
  YAMASHITA Satoshi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Gunma University
Structure and Function of Genes for Phospholipid Synthesis
- Principal Investigator
  
  YAMASHITA Satoshi
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  代謝生物化学
- Research Institution
  Gunma University
Study on the phosphatidylcholine-synthetic enzyme genes in mammalian cellsPrincipal Investigator
- Principal Investigator
  
  HOSAKA Kohei
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Gunma University School of Medicine

All 2016 2015 2011 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Patent

[Journal Article] アルキルベンゼンスルホン酸によるプロテインホスファターゼ1α活性への阻害作用の研究2015
- Author(s)
  伊藤　昇、中島　徹、菅井貴裕、山際教之、嶋田淳子、保坂公平、田中　進
- Journal Title
  
  北関東医学
  
  Volume: 65 Pages: 53-59
- NAID
  130005060948
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26340027
[Journal Article] Cyclophilin C-associated protein regulation of phagocytic functions via NFAT activation in macrophages2011
- Author(s)
  Yamaguchi R, Hosaka M, Torii S, Hou N, Saito N, Yoshimoto Y, Imai H, Takeuchi T
- Journal Title
  
  Brain Res
  
  Volume: 23 Pages: 55-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591577
[Journal Article] Cyclophilin C-associated protein regulation of phagocytic functions via NFAT activation in macrophages2011
- Author(s)
  Yamaguchi R, Hosaka M, Torii S, Hou N, Saito N, Yoshimoto Y, Imai H, Takeuchi T
- Journal Title
  
  Brain Res.
  
  Volume: 23 Pages: 55-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591577
[Journal Article] Cyclophilin C-associated protein regulation of phagocytic functions via NFAT activation in macrophages.2011
- Author(s)
  Yamaguchi R, Hosaka M, Torii S, Hou N, Saito N, Yoshimoto Y, Imai H, Takeuchi T.
- Journal Title
  
  Brain Res.
  
  Volume: 23 Pages: 55-65
- DOI
  10.1016/j.brainres.2011.03.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249063, KAKENHI-PROJECT-22591577
[Journal Article] Biological activities of novel derivatives of DIF-1 isolated from Dictyostelium2008
- Author(s)
  Kikuchi H, Ishiko S, Oshima Y, Gonkan N, Hosaka K & Kubohara Y.
- Journal Title
  
  Biochem.Biophys. Res. Commun 377
  
  Pages: 1012-1017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590136
[Journal Article] Pharmacological evidence that stalk cell differentiation involves increases in the intracellular Ca^<2+> and H^+ concentrations in Dictyostelium discoidewn.2007
- Author(s)
  Kubohara Y, Arai A, Gokan N, Hosaka K.
- Journal Title
  
  Develop. Growth ＆ Differ. 49・3
  
  Pages: 253-264
- Data Source
  KAKENHI-PROJECT-17590115
[Journal Article] Dictyostelium differentiation-inducing factor-1 induces glucose transporter 1 translocation and promotes glucose uptake in mammalian cells2007
- Author(s)
  Omata W, Shibata H, Nagasawa M,Kojima I, Kikuchi H, Oshima Y, Hosaka K,& Kubohara Y
- Journal Title
  
  FEBS Journal 274
  
  Pages: 3392-3404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590136
[Journal Article] Dihydrodictyopyrone A and C : New members of dictyopyrone family isolated from Dictyostelium cellular slime molds2007
- Author(s)
  Kikuchi H, Nakamura K, Kubohara Y, Gokan N, Hosaka K, Maeda Y, & Oshima Y.
- Journal Title
  
  Tetrahedron Lett 48
  
  Pages: 5905-5909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590136
[Journal Article] Anti-leukemic activities of Dictyostelium secondary metabolites : A novel aromatic metabolite, 4-methyl-5-n-pentylbenzene-1,3-diol, isolated from Dictyostelium mucoroides suppresses cell growth in human leukemia K562 cells.2006
- Author(s)
  Kikuchi H, Oshima Y, Ichimura A, Gokan N, Hasegawa A, Hosaka K, KuboharaY.
- Journal Title
  
  Life Sciences 80・2
  
  Pages: 160-165
- Data Source
  KAKENHI-PROJECT-17590115
[Journal Article] Zinc ions suppress mitogen-activated interleukin-2 production in Jurkat cells.2005
- Author(s)
  Tanaka, S., Akaishi, E., Hosaka, K., Okamura, S., Kubohara, Y.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 335
  
  Pages: 162-167
- Data Source
  KAKENHI-PROJECT-17590115
[Journal Article] Structural requirements of Dictyosterium differentiation-inducing Factors for their stalk-cell-inducing activity in Dictyosterium cells and anti-proliferative activity in K562 human leukemic cells.2005
- Author(s)
  Gokan N, Kikuchi H, Nakamura K, Oshima Y, Hosaka K, Kubohara Y.
- Journal Title
  
  Biochemical Pharmacology 70
  
  Pages: 676-685
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Dictyopyrones, novel α-pyronoids isolated from Dictyostelium spp., p romote stalk cell differentiation in Dictyostelium discoideum.2005
- Author(s)
  Arai A, Goto Y, Hasegawa A, Hosaka H, Kikuchi H, Oshima Y, Tanaka S, Kubohara Y.
- Journal Title
  
  Differentiation 73
  
  Pages: 377-384
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Structural requirements of Dictyosterium differentiation-inducing factors for their stalk-cell-inducing activity in Dictyosterium cells and anti-proliferative activity in K562 human leukemic cells.2005
- Author(s)
  Gokan N, Kikuchi H, Nakamura K, Oshima Y, Hosaka K, Kubohara Y
- Journal Title
  
  Biochemical Pharmacolgy 70
  
  Pages: 676-685
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Dictyopyrones, novel α-pyronoids isolated from Dictyostelium spp., promote stalk cell differentiation in Dictyostelium discoideum.2005
- Author(s)
  Arai A, Goto Y, Hasegawa A, Hosaka H, Kikuchi H, Oshima Y, Tanaka S, Kubohara Y
- Journal Title
  
  Differentiation 73
  
  Pages: 377-384
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Dictyopyrones, novel α-pyronoids isolated from Dictyostelium spp.,Promote stalk cell differentiation in Dictyostelium discoideum.2005
- Author(s)
  Arai A, Goto Y, Hasegawa A, Hosaka H, Kikuchi H, Oshima Y, Tanaka S, Kubohara Y.
- Journal Title
  
  Differentiation 73
  
  Pages: 377-384
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Dictyopyrones, novel α-pyronoids isolated from Dictyostelium spp., promote stalk cell differentiation in Dictyostelium discoideum.2005
- Author(s)
  Arai, A., Goto, Y., Hasegawa, A., Hosaka, K., Kikuchi, H., Oshima, Y., Tanaka, S., Kubohara, Y.
- Journal Title
  
  Differentiation 73
  
  Pages: 377-384
- Data Source
  KAKENHI-PROJECT-17590115
[Journal Article] Structural requirements of Dictyostelium differentiation-inducing factors for their stalk-cell-inducing activity in Dictyostelium cells and anti-proliferative activity in K562 human leukemic cells.2005
- Author(s)
  Gokan, N., Kikuchi, H., Nakamura, K., Oshima, Y., Hosaka, K., Kubohara, Y.
- Journal Title
  
  Biochem.Pharmacol. 70
  
  Pages: 676-685
- Data Source
  KAKENHI-PROJECT-17590115
[Journal Article] Structural requirements of Dictyosterium differentiation-inducing Factors for their stalk-cell-inducing activity in Dictyosterium cells and anti-proliferative activity in K562 human leukemic cells.2005
- Author(s)
  Gokan N, Kikuchi H, Nakamura K, Oshima Y, Hosaka K, Kubohara Y.
- Journal Title
  
  Biochmical Pharmacology 70
  
  Pages: 676-685
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Prespore-to-stalk conversion involves the production of a pathway-specific glycoprotein, wst25, in the cellular slime mould Dictyosterium discoideum.2004
- Author(s)
  Kubohara, Y., Arai, A., Takahashi, K., Hosaka, K., Okamoto, K.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 320
  
  Pages: 468-473
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Prespore-to-stalk conversion involves the production of a pathway-specific glvcoprotein, wst25 in the cellular slime mould Dictyosterium discoideum.2004
- Author(s)
  Kubohara, Y., Arai, A., Takahashi, K., Hosaka, K., Okamoto, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 320
  
  Pages: 468-473
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1/2 activity.2004
- Author(s)
  Akaishi E, Narita T, Kawai S, Miw, Hosaka K, Kubohara Y.
- Journal Title
  
  Eur J Pharmacol. 485
  
  Pages: 21-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Prespore-to-stalk convertion involves the production of a pathway-specific glycoprotein, wst25, in the cellular slime mould Dictyosterium discoideum.2004
- Author(s)
  Kubohara Y, Arai A, Takahashi K, Hosaka K, Okamoto K
- Journal Title
  
  Biochem.Biophys.Res.Commun. 320
  
  Pages: 468-473
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1/2 activity.2004
- Author(s)
  Akaishi, E., Narita, T., Kawai, S., Miwa, Y, Sasaguri, T., Hosaka, K., Kubohara, Y.
- Journal Title
  
  Eur.J.Pharmacol. 485
  
  Pages: 21-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590123
[Journal Article] Differentiation-inducing factor-1-induced growth arrest of K562 leukemia2004
- Author(s)
  Akaishi E, Narita T, Kawai S, Miwa Y, Sasakura T, Hosaka K, Kiyohara Y
- Journal Title
  
  European Journal of Pharmacology 485
  
  Pages: 21-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590123
[Journal Article] Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) is a pharmacological target of differentiation-inducing factor-1, an anti-tumor agent isolated from Dictyostelium.2004
- Author(s)
  Shimizu K, Murata T, Tagawa T, Takahashi K, Abe Y, Hosaka K, Kubohara Y
- Journal Title
  
  Cancer Research 64
  
  Pages: 2568-2571
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) is a pharmacological target of differentiation-inducing factor-1, an anti-tumor agent isolated from Dictyostelium.2004
- Author(s)
  Shimizu, K., Murata, T., Tagawa, T., Takahashi, K., Ishikawa, R., Abe, Y, Hosaka, K., Kubohara, Y.
- Journal Title
  
  Cancer Res. 64
  
  Pages: 2568-2571
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590123
[Journal Article] Calmodulin-dependent cyclic nucleotide phosphodiesterase(PDE1) is a pharmacological target of differentiation-inducing factor-1, an anti-tumor agent isolated from Dictyostelium.2004
- Author(s)
  Shimizu K, Murata T, Tagawa T, Takahashi K, Abe Y, Hosaka K, Kubohara Y.
- Journal Title
  
  Cancer Research 64
  
  Pages: 2568-2571
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Calmodulin-dependent cyclic nucleotide phosphoiesterase (PDE1) is a pharmacological target of differentiation-inducing factor-1, an anti-tumor agent isolated from Dictyostelium.2004
- Author(s)
  Shimizu K, Murata T, Tagawa T, Takahashi K, Ishikawa R, Abe Y, Hosaka K, Kubohara Y.
- Journal Title
  
  Cancer Research 64
  
  Pages: 2568-2571
- Data Source
  KAKENHI-PROJECT-15590123
[Journal Article] Zinc inhibits calcineurin activity in vitro by competing with nickel.2003
- Author(s)
  Takahashi K, Akaishi E, Abe Y, Ishikawa R, Tanaka S, Hosaka K, Kubohara Y
- Journal Title
  
  Biochem.Biophys.Res.Commun. 307
  
  Pages: 64-68
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590123
[Journal Article] Zinc inhibits calcineurin activity in vitro by competing with nickel.2003
- Author(s)
  Takahashi, N., Akaishi, E., Abe, Y, Ishikawa, R., Tanaka, S., Hosaka, K., Kubohara, Y.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 307
  
  Pages: 64-68
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590123
[Journal Article] Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1/2 activity2003
- Author(s)
  Akashi E, Narita T, Kawai S, Miwa Y, Sasaguri T, Hosaka K, Kubohara Y.
- Journal Title
  
  European Journal of Pharmacology 485
  
  Pages: 21-29
- Data Source
  KAKENHI-PROJECT-15590123
[Patent] 抗腫瘍剤2006
- Inventor(s)
  久保原禅, 保坂公平
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2006-022530
- Filing Date
  2006-01-31
- Data Source
  KAKENHI-PROJECT-17590115
[Patent] 抗腫瘍剤2006
- Inventor(s)
  久保原禅, 保坂公平
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2006-022530
- Filing Date
  2006-01-31
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590115
[Patent] 細胞性粘菌より単離された新規抗腫瘍因子2005
- Inventor(s)
  久保原禅, 保坂公平
- Filing Date
  2005-08-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Patent] 抗腫瘍剤2005
- Inventor(s)
  久保原禅, 保坂公平
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2005-223927
- Filing Date
  2005-08-02
- Data Source
  KAKENHI-PROJECT-17590115
[Patent] 抗腫瘍剤2005
- Inventor(s)
  久保原禅, 保坂公平
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2005-223927
- Filing Date
  2005-08-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590115
[Patent] PDE1阻害剤2004
- Inventor(s)
  久保原禅, 保坂公平, 清水香澄, 村田琢, 田川俊郎
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2004-108018
- Filing Date
  2004-03-31
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590123
[Patent] PDE1阻害剤2004
- Inventor(s)
  久保原禅, 保坂公平, 清水香澄, 村田琢, 田川俊郎
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2004-108018
- Filing Date
  2004-03-31
- Data Source
  KAKENHI-PROJECT-15590123
[Presentation] 直鎖型アルキルベンゼンスルホン酸のウシ脳カルシニューリン活性に対する影響2016
- Author(s)
  秋山珠璃、中島　徹、山際教之、保坂公平、田中　進
- Organizer
  日本生化学会
- Place of Presentation
  仙台市
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26340027
[Presentation] 直鎖型アルキルベンゼンスルホン酸のプロテインホスファターゼ活性に対する影響2015
- Author(s)
  田中　進、伊藤　昇、菅井貴裕、中島　徹、秋山珠璃、山際教之、嶋田（中島）淳子、保坂公平
- Organizer
  日本生化学会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26340027
[Presentation] Biologically active small molecules produced by cellular slime molds2008
- Author(s)
  Kikuchi H, Ishiko S, Amagai A, Maeda Y Hosaka H, Kuboahra Y,& Oshima Y.
- Organizer
  International Dictyostelium conference
- Place of Presentation
  Tsukuba
- Year and Date
  2008-09-16
- Data Source
  KAKENHI-PROJECT-19590136
[Presentation] 哺乳類細胞に対するDIF-1の糖代謝促進作用2007
- Author(s)
  久保原禅、小俣和香、柴田宏、小島至、保坂公平、菊地晴久, 大島吉輝
- Organizer
  第10回細胞性粘菌研究会
- Place of Presentation
  弘前
- Year and Date
  2007-11-03
- Data Source
  KAKENHI-PROJECT-19590136
[Presentation] Anti-leukemic activities of Dictyostelium secondary metabolites : A novel aromatic metabolite, 4-methyl-5- n-pentylbenzene-1,3-diol, isolated from Dictyostelium mucoroides suppresses cell growth in human leukemia K562 and HL-60 cells2007
- Author(s)
  久保原禅、後閑直美、保坂公平、菊地晴久、大島吉輝
- Organizer
  細胞生物・発生生物合同学会
- Place of Presentation
  福岡
- Year and Date
  2007-05-30
- Data Source
  KAKENHI-PROJECT-19590136
[Presentation] 哺乳類細胞に対するDIF-1およびその誘導体の糖代謝促進作用2007
- Author(s)
  久保原禅、小俣和香、柴田宏、小島至、保坂公平、菊地晴久, 大島吉輝
- Organizer
  第10回細胞性粘菌研究会
- Place of Presentation
  弘前
- Year and Date
  2007-11-04
- Data Source
  KAKENHI-PROJECT-19590136
[Presentation] マイトジェン刺激したJurkat T細胞のサイトカイン産生に対するアルキルベンゼンスルホン酸の効果
- Author(s)
  田中　進、島田沙織、神谷　明、中島　徹、秋山珠璃、伊藤　昇、山際教之、保坂公平
- Organizer
  日本生化学会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26340027

1. YAMASHITA Satoshi (50025623)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. UCHIDA Tsutomu (00160276)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. SUGIMOTO Hiroyuki (00235897)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. KUBOHARA Yuzuru (00221937)

# of Collaborated Projects: 4 results

# of Collaborated Products: 29 results
5. KOJIMA Itaru (60143492)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
6. MIYAMOTO Kaoru (30125877)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. INAZU Tetsuya (00242587)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. YAMADA Kazuya (20263238)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 峯岸敬 (00209842)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. IMAI Hideaki (70359587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. SAITO Nobuhito (60262002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ISHIZAKI Yasuki (90183003)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SETOU Mitsutoshi (20302664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TANAKA Susumu (70348142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. KODAKI Tsutomu (70170264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NIKAWA Jun-ichi (00134271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. OKAMURA Shinichi (20224058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SUZUKI Mamoru (60056033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. SATO Kumiko (80008268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SUZUE Kazutomo (00333485)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KATAKURA Ken (10130155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KAWAZU Shinichiro (60312295)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. KANO Shigeyuki (60233912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. ADACHI Hiroyuki (00211699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. KAWAI Shinjiro (70131381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 山際教之 (70433638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
27. 堀川弘吏

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 宮脇哲

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 小野秀明

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 斎藤延人

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

HOSAKA Kohei 保坂 公平

保坂 公平 ホサカ コウヘイ

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Search for novel anti-tumor drugs and study on the action mechanismPrincipal Investigator

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Identification of receptor of anti-tumor factor DIF and development of new DIF-analogsPrincipal Investigator

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Study on the tissue specific expression of phosphatidylinositol synthase and its function.Principal Investigator

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2種類のホスファチジルイノシトール輸送蛋白質の発現調節と機能の解析Principal Investigator

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酵母の脂質合成関連遺伝子群のイノシトールとコリンによる発現調節の分子生物学的解析Principal Investigator

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HOSAKA Kohei 保坂公平

保坂公平ホサカコウヘイ