FURUTA Takashi 古田隆

… Alternative Names

古田隆フルタタカシ

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Researcher Number	70120152
Other IDs
Affiliation (based on the past Project Information) *help	2012: 東京薬科大学, 薬学部, 教授 2004 – 2006: 東京薬科大学, 薬学部, 助教授 1995 – 2002: 東京薬科大学, 薬学部, 助教授 1991 – 1993: 東京薬科大学, 薬学部, 助教授 1987 – 1988: 東京薬科大学, 薬学部, 助教授 1986: 東京薬大, 薬学部, 講師
Review Section/Research Field	Principal Investigator Physical pharmacy / 応用薬理学・医療系薬学 / Chemical pharmacy Except Principal Investigator 応用薬理学・医療系薬学 / Medical pharmacy / Food science
Keywords	Principal Investigator GC-MS / ウロカニン酸 / 酵素反応機構 / MS / GC / Urocanic Acid / 安定同位体 / 6β-hydroxycortisol / cortisone / cortisol … More / corticosteroids / 安定同位体標識体 / Stable Isotopes / In Vivo Enzyme Activities / Histidine Ammonia-Lyase / 代謝異常症 / in vivo酵素活性 / 体内動態 / L-ヒスチジン / L-Histidine / 脱離反応 / ヒスチジンアンモニア・リアーゼ / _L-ヒスチジン / ヒスチダーゼ / ヒスチジン血症 / 脱アミノ化反応 / 安定同位元素 / ヒスチジン / indan synthon method / stable isotopes / carbone-13 / deuterium / prednisolone / indan法 / carbon-13 / Metabolism / In Vivo Enzyme Mechanism / 代謝 / in vivo酵素反応機構 / ヒスチジンアンモニアリアーゼ / Metabolic Disorders / Pharmacokinetics / _L-Histidine / 酵素反応 / 同位体希釈質量分析 / 安定同位体標識体合成 / Deuterium Isotope Effect / Reversibility / Rate-limiting Step / Enzymatic Reaction / beta-Elimination / Histidine Ammonia-lyase / 同位体効果 / histidine ammoniaーlyase / urocanic acid / Lーhistidine / 重水素同位体効果 / 律速段階 / β‐脱離反応 / L‐ヒスチジン / 重水素-水素交換 / 可逆反応性 / β-脱離反応 / ヒスチジンアンモニア・リアーゼ / ヒスチジンアンモニアーリアーゼ / 標識 … More Except Principal Investigator GC-MS-SIM / コルチゾン / コルチゾール / hypertension / cortisone / cortisol / GC-MS分析 / GC-MS / 体内動態 / stable isotope methodology / 11β-HSD2酵素活性評価 / 安定同位体標識 / cortisol ratio / urinary cortisone / 高血圧 / 速度論的解析 / 安定同位体トレーサー法 / renal disease / 11β-activity / グリチルリチン酸 / 安定同位体標識体 / 11β-HSD2の酵素活性 / 腎疾患患者 / F比 / 尿中E / 11β-HSD2酵素活性 / pharmacokinetic analysis / 13C_4-and 2H_1-label / 11β-HSD activity / 速度論解析 / ^<13>C及び^2H標識 / 11β-HSD活性 / pharmacokinetics / 11β-HSD actitity / stabel isotope methodology / IIβ-HSD / 重水素標識体 / ヒト in vivo 酵素活性 / GC-MS 分析 / ヒトin vivo酵素活性 / 尿中代謝物 / 重水素標識コルチゾン / 重水素標識コルチゾール / 高血圧症 / cortisol濃度比 / 尿中cortisone / 11β-HSD酵素活性 / Pharmacokinetics / Prednisone / Prednisolone / Cortisone / Cortisol / Deuterium labeling / Stable isotopes / ステロイドホルモン分泌異常機構 / GC‐MS法 / 小児ネフローゼ患者 / プレドニゾン / プレドニゾロン / 安定同位体標識ステロイド / SULT / UGT / 薬物代謝酵素 / 大豆イソフラボン Less

Evaluation of the in vivo activity of phase II drug-metabolizing enzymes using soy isoflavone metabolism
- Principal Investigator
  
  HOSODA Kaori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Food science
- Research Institution
  Kyorin University
Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension
- Principal Investigator
  
  KASUYA Yasuji
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Sciences
Enantioselective synthesis of glucocorticoids by the indan synthon method and its application to the preparation of the multi-labeled glucocorticoids with stable isotopesPrincipal Investigator
- Principal Investigator
  
  FURUTO Takashi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension
- Principal Investigator
  
  KASUYA Yasuji
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo University of Pharmacy and life Science
A New Method for Assessing the In Vitro and In Vivo Enzyme Reaction Mechanisms Using Stable Isotope MethodologyPrincipal Investigator
- Principal Investigator
  
  FURUTA Takashi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension
- Principal Investigator
  
  KASUYA Yasuji
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo University of Pharmacy and Life Science
A New Assessment of In Vivo Enzyme Activities in Metbolic Disorders Using Stable Isotope MethodologyPrincipal Investigator
- Principal Investigator
  
  FURUTA Takashi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo University of Pharmacy and Life Science
Mechanistic Study on the Cortisol Metabolism and Secretion in the Endocrinological Disorders
- Principal Investigator
  
  KASUYA Yasuji
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo College of Pharmacy
Study on the Enzymatic Reaction Mechanism catalyzed by Histidine Ammonia-Lyase Using Stable Isotope MethodologyPrincipal Investigator
- Principal Investigator
  
  FURUTA Takashi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo College of Pharmacy
安定同位体トレーサー法によるヒスチジンの体内動態とヒスチジン血症の診断法開発研究Principal Investigator
- Principal Investigator
  
  古田隆
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo University of Pharmacy and Life Science
安定同位体トレーサー法によるヒスチジンの体内動態とヒスチジン血症の診断法開発研究Principal Investigator
- Principal Investigator
  
  古田隆
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Institution
  Tokyo University of Pharmacy and Life Science

All 2013 2012 2011 2005

All Journal Article Presentation Book

[Book] Isoflavones: Chemistry, Analysis, Function and Effects (Food and Nutritional Components in Focus)2013
- Author(s)
  Kazuo Ishii, Kaori Hosoda, Takashi Furuta, (Chapter 13)
- Publisher
  RSC Publishing
- Data Source
  KAKENHI-PROJECT-22780125
[Journal Article] Metabolism and disposition of isoflavone conjugated metabolites in humans after ingestion of kinako2011
- Author(s)
  Kaori Hosoda, Takashi Furuta, Kazuo Ishii
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 39 Issue: 9 Pages: 1762-1767
- DOI
  10.1124/dmd.111.038281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780125
[Journal Article] Validation of the plasma half-life of 11α-deuterium cortisol as a sensitive indexr for the analysis of 11β-HSD2 activity in vivo.2005
- Author(s)
  Kasuya Y, Yokokawa A, Hamura K, Shibasaki H, Furuta T
- Journal Title
  
  Steroids 70・12
  
  Pages: 811-816
- Data Source
  KAKENHI-PROJECT-16590126
[Journal Article] Use of 11α-deuterium labeled cortisol as a tracer for assessing reduced 11β-HSD2 activity in vivo following glycyrrhetinic acid ingestion in a human subject2005
- Author(s)
  Kasuya Y, Yokokawa A, Takashima S, Furuta T, Shibasaki H
- Journal Title
  
  Steroids 70・2
  
  Pages: 117-125
- Data Source
  KAKENHI-PROJECT-16590126
[Presentation] イソフラボンGenisteinの代謝物生成に関与するUGT酵素分子種の解明2012
- Author(s)
  西浦彩、細田香織、古田隆、石井和夫
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22780125
[Presentation] イソフラボンGenisteinの代謝に関与するUGT分子種の解明2011
- Author(s)
  細田香織、小林志江、古田隆、石井和夫
- Organizer
  日本農芸化学会2011年度大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22780125

1. KASUYA Yasuji (90096686)

# of Collaborated Projects: 10 results

# of Collaborated Products: 2 results
2. SHIBASAKI Hiromi (20206121)

# of Collaborated Projects: 8 results

# of Collaborated Products: 2 results
3. HOSODA Kaori (60433728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. ISHII Kazuo (80137968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. KATO Tomohisa (80152726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YOKOKAWA Akitomo (70328558)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

FURUTA Takashi 古田 隆

古田 隆 フルタ タカシ

Research Projects

Research Products

Co-Researchers

Evaluation of the in vivo activity of phase II drug-metabolizing enzymes using soy isoflavone metabolism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Enantioselective synthesis of glucocorticoids by the indan synthon method and its application to the preparation of the multi-labeled glucocorticoids with stable isotopesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A New Method for Assessing the In Vitro and In Vivo Enzyme Reaction Mechanisms Using Stable Isotope MethodologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A New Assessment of In Vivo Enzyme Activities in Metbolic Disorders Using Stable Isotope MethodologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanistic Study on the Cortisol Metabolism and Secretion in the Endocrinological Disorders

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the Enzymatic Reaction Mechanism catalyzed by Histidine Ammonia-Lyase Using Stable Isotope MethodologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

安定同位体トレーサー法によるヒスチジンの体内動態とヒスチジン血症の診断法開発研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

安定同位体トレーサー法によるヒスチジンの体内動態とヒスチジン血症の診断法開発研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Book] Isoflavones: Chemistry, Analysis, Function and Effects (Food and Nutritional Components in Focus)2013

Author(s)

Publisher

Data Source

[Journal Article] Metabolism and disposition of isoflavone conjugated metabolites in humans after ingestion of kinako2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Validation of the plasma half-life of 11α-deuterium cortisol as a sensitive indexr for the analysis of 11β-HSD2 activity in vivo.2005

FURUTA Takashi 古田隆

古田隆フルタタカシ