FURUTA Takashi 古田隆

… Alternative Names

古田隆フルタタカシ

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Researcher Number	70120152
Other IDs
Affiliation (based on the past Project Information) *help	2012: 東京薬科大学, 薬学部, 教授 2004 – 2006: 東京薬科大学, 薬学部, 助教授 1995 – 2002: 東京薬科大学, 薬学部, 助教授 1991 – 1993: 東京薬科大学, 薬学部, 助教授 1987 – 1988: 東京薬科大学, 薬学部, 助教授 1986: 東京薬大, 薬学部, 講師
Review Section/Research Field	Principal Investigator 応用薬理学・医療系薬学 / Physical pharmacy / Chemical pharmacy Except Principal Investigator 応用薬理学・医療系薬学 / Food science / Medical pharmacy
Keywords	Principal Investigator ウロカニン酸 / GC-MS / 酵素反応機構 / 安定同位体 / Urocanic Acid / GC / MS / ヒスチジン / 安定同位元素 / 脱アミノ化反応 … More / ヒスチジン血症 / ヒスチダーゼ / _L-ヒスチジン / ヒスチジンアンモニア・リアーゼ / 脱離反応 / L-Histidine / L-ヒスチジン / 体内動態 / in vivo酵素活性 / 代謝異常症 / Histidine Ammonia-Lyase / In Vivo Enzyme Activities / Stable Isotopes / 安定同位体標識体 / corticosteroids / cortisol / cortisone / 6β-hydroxycortisol / 標識 / ヒスチジンアンモニアーリアーゼ / ヒスチジンアンモニア・リアーゼ / β-脱離反応 / 可逆反応性 / 重水素-水素交換 / L‐ヒスチジン / β‐脱離反応 / 律速段階 / 重水素同位体効果 / Lーhistidine / urocanic acid / histidine ammoniaーlyase / 同位体効果 / Histidine Ammonia-lyase / beta-Elimination / Enzymatic Reaction / Rate-limiting Step / Reversibility / Deuterium Isotope Effect / 安定同位体標識体合成 / 同位体希釈質量分析 / 酵素反応 / _L-Histidine / Pharmacokinetics / Metabolic Disorders / ヒスチジンアンモニアリアーゼ / in vivo酵素反応機構 / 代謝 / In Vivo Enzyme Mechanism / Metabolism / carbon-13 / indan法 / prednisolone / deuterium / carbone-13 / stable isotopes / indan synthon method … More Except Principal Investigator GC-MS-SIM / コルチゾール / コルチゾン / 体内動態 / GC-MS / GC-MS分析 / cortisol / cortisone / hypertension / 安定同位体トレーサー法 / 速度論的解析 / 高血圧 / urinary cortisone / cortisol ratio / 安定同位体標識 / 11β-HSD2酵素活性評価 / stable isotope methodology / 大豆イソフラボン / 薬物代謝酵素 / UGT / SULT / 安定同位体標識ステロイド / プレドニゾロン / プレドニゾン / 小児ネフローゼ患者 / GC‐MS法 / ステロイドホルモン分泌異常機構 / Stable isotopes / Deuterium labeling / Cortisol / Cortisone / Prednisolone / Prednisone / Pharmacokinetics / 11β-HSD酵素活性 / 尿中cortisone / cortisol濃度比 / 高血圧症 / 重水素標識コルチゾール / 重水素標識コルチゾン / 尿中代謝物 / ヒトin vivo酵素活性 / GC-MS 分析 / ヒト in vivo 酵素活性 / 重水素標識体 / IIβ-HSD / stabel isotope methodology / 11β-HSD actitity / pharmacokinetics / 11β-HSD活性 / ^<13>C及び^2H標識 / 速度論解析 / 11β-HSD activity / 13C_4-and 2H_1-label / pharmacokinetic analysis / 11β-HSD2酵素活性 / 尿中E / F比 / 腎疾患患者 / 11β-HSD2の酵素活性 / 安定同位体標識体 / グリチルリチン酸 / 11β-activity / renal disease Less

Evaluation of the in vivo activity of phase II drug-metabolizing enzymes using soy isoflavone metabolism
- Principal Investigator
  
  HOSODA Kaori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Food science
- Research Institution
  Kyorin University
Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension
- Principal Investigator
  
  KASUYA Yasuji
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Sciences
Enantioselective synthesis of glucocorticoids by the indan synthon method and its application to the preparation of the multi-labeled glucocorticoids with stable isotopesPrincipal Investigator
- Principal Investigator
  
  FURUTO Takashi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension
- Principal Investigator
  
  KASUYA Yasuji
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo University of Pharmacy and life Science
A New Method for Assessing the In Vitro and In Vivo Enzyme Reaction Mechanisms Using Stable Isotope MethodologyPrincipal Investigator
- Principal Investigator
  
  FURUTA Takashi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension
- Principal Investigator
  
  KASUYA Yasuji
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo University of Pharmacy and Life Science
A New Assessment of In Vivo Enzyme Activities in Metbolic Disorders Using Stable Isotope MethodologyPrincipal Investigator
- Principal Investigator
  
  FURUTA Takashi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo University of Pharmacy and Life Science
Mechanistic Study on the Cortisol Metabolism and Secretion in the Endocrinological Disorders
- Principal Investigator
  
  KASUYA Yasuji
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo College of Pharmacy
Study on the Enzymatic Reaction Mechanism catalyzed by Histidine Ammonia-Lyase Using Stable Isotope MethodologyPrincipal Investigator
- Principal Investigator
  
  FURUTA Takashi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo College of Pharmacy
安定同位体トレーサー法によるヒスチジンの体内動態とヒスチジン血症の診断法開発研究Principal Investigator
- Principal Investigator
  
  古田隆
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo University of Pharmacy and Life Science
安定同位体トレーサー法によるヒスチジンの体内動態とヒスチジン血症の診断法開発研究Principal Investigator
- Principal Investigator
  
  古田隆
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Institution
  Tokyo University of Pharmacy and Life Science

All 2013 2012 2011 2005

All Journal Article Presentation Book

[Book] Isoflavones: Chemistry, Analysis, Function and Effects (Food and Nutritional Components in Focus)2013
- Author(s)
  Kazuo Ishii, Kaori Hosoda, Takashi Furuta, (Chapter 13)
- Publisher
  RSC Publishing
- Data Source
  KAKENHI-PROJECT-22780125
[Journal Article] Metabolism and disposition of isoflavone conjugated metabolites in humans after ingestion of kinako2011
- Author(s)
  Kaori Hosoda, Takashi Furuta, Kazuo Ishii
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 39 Pages: 1762-1767
- DOI
  10.1124/dmd.111.038281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780125
[Journal Article] Validation of the plasma half-life of 11α-deuterium cortisol as a sensitive indexr for the analysis of 11β-HSD2 activity in vivo.2005
- Author(s)
  Kasuya Y, Yokokawa A, Hamura K, Shibasaki H, Furuta T
- Journal Title
  
  Steroids 70・12
  
  Pages: 811-816
- Data Source
  KAKENHI-PROJECT-16590126
[Journal Article] Use of 11α-deuterium labeled cortisol as a tracer for assessing reduced 11β-HSD2 activity in vivo following glycyrrhetinic acid ingestion in a human subject2005
- Author(s)
  Kasuya Y, Yokokawa A, Takashima S, Furuta T, Shibasaki H
- Journal Title
  
  Steroids 70・2
  
  Pages: 117-125
- Data Source
  KAKENHI-PROJECT-16590126
[Presentation] イソフラボンGenisteinの代謝物生成に関与するUGT酵素分子種の解明2012
- Author(s)
  西浦彩、細田香織、古田隆、石井和夫
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22780125
[Presentation] イソフラボンGenisteinの代謝に関与するUGT分子種の解明2011
- Author(s)
  細田香織、小林志江、古田隆、石井和夫
- Organizer
  日本農芸化学会2011年度大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22780125

1. KASUYA Yasuji (90096686)

# of Collaborated Projects: 10 results

# of Collaborated Products: 2 results
2. SHIBASAKI Hiromi (20206121)

# of Collaborated Projects: 8 results

# of Collaborated Products: 2 results
3. HOSODA Kaori (60433728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. ISHII Kazuo (80137968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. KATO Tomohisa (80152726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YOKOKAWA Akitomo (70328558)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

FURUTA Takashi 古田 隆

古田 隆 フルタ タカシ

Research Projects

Research Products

Co-Researchers

Evaluation of the in vivo activity of phase II drug-metabolizing enzymes using soy isoflavone metabolism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Enantioselective synthesis of glucocorticoids by the indan synthon method and its application to the preparation of the multi-labeled glucocorticoids with stable isotopesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A New Method for Assessing the In Vitro and In Vivo Enzyme Reaction Mechanisms Using Stable Isotope MethodologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A New Assessment of In Vivo Enzyme Activities in Metbolic Disorders Using Stable Isotope MethodologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanistic Study on the Cortisol Metabolism and Secretion in the Endocrinological Disorders

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the Enzymatic Reaction Mechanism catalyzed by Histidine Ammonia-Lyase Using Stable Isotope MethodologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

安定同位体トレーサー法によるヒスチジンの体内動態とヒスチジン血症の診断法開発研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

安定同位体トレーサー法によるヒスチジンの体内動態とヒスチジン血症の診断法開発研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Book] Isoflavones: Chemistry, Analysis, Function and Effects (Food and Nutritional Components in Focus)2013

Author(s)

Publisher

Data Source

[Journal Article] Metabolism and disposition of isoflavone conjugated metabolites in humans after ingestion of kinako2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Validation of the plasma half-life of 11α-deuterium cortisol as a sensitive indexr for the analysis of 11β-HSD2 activity in vivo.2005

FURUTA Takashi 古田隆

古田隆フルタタカシ