KAWAI Shinichi 川合眞一

… Alternative Names

河合眞一カワイシンイチ

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Researcher Number	70129401
Other IDs
Affiliation (based on the past Project Information) *help	2005 – 2016: 東邦大学, 医学部, 教授 2004: Toho University, School of Medicine, Professor, 医学部・内科学講座, 教授 2002 – 2003: 聖マリアンナ医科大学, 難病治療研究センター, 教授 1999: Institute of Medical Science, St.Marianna University School of Medicine, 難病治療研究センター, 教授 1998: 聖マリアンナ医科大学, 難病治療研究センター, 助教授
Review Section/Research Field	Principal Investigator 膠原病・アレルギー・感染症内科学 / Applied pharmacology / 応用薬理学・医療系薬学 / 内科学一般 / Collagenous pathology/Allergology
Keywords	Principal Investigator synovial fibroblasts / NSAIDs / apoptosis / rheumatoid arthritis / colon cancer / celecoxib / SW480 / HT-29 / TT101 / celecoxib derivative … More / PGDS / mPGES-1 / PPARgamma / 関節リウマチ / triptolide / Tripterygium wilfordii Hook F / Ki-ras gene / synovial cells / TNF-α / IL-1β / new carrier / antisense DNA / IL-1 / TNF / 遺伝子の細胞内導入 / キャリアー / アンチセンスDNA / 民族差 / 薬理遺伝学 / 遺伝子多型 / 細胞内代謝 / メトトレキサート / ケメリン / レプチン / アディポネクチン / レジスチン / アディポカイン / 膠原病 / adiponectin / adipocytokine / アディポサイトカイン / リウマチ学 Less

Pharmacogenetic study of methotrexate in patients with rheumatoid arthritis.Principal Investigator
- Principal Investigator
  
  KAWAI Shinichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Toho University
Adipokine network in systemic autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  KAWAI Shinichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Toho University
Clinical Significance of Adipocytokines in Rheumatoid ArthritisPrincipal Investigator
- Principal Investigator
  
  KAWAI Shinichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Toho University
An Experimental Study ofANovel Pro-ApoptoticAgent for RheumatoidArthritis and MalignancyPrincipal Investigator
- Principal Investigator
  
  KAWAI Shinichi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Toho University
New therapeutic approach for rheumatoid arthritis by targeting the intracellular molecule.Principal Investigator
- Principal Investigator
  
  KAWAI Shinichi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Toho University School of Medicine
  St. Marianna University School of Medicine
Basic Studies of Novel Gene Therapy by Regulation of Transcription of the Inflammation-Related Gene.Principal Investigator
- Principal Investigator
  
  KAWAI Shinichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Institute of Medical Science, St.Marianna University

[Book] Effects of adipokines on prostaglandin E2 production by rheumatoid synovial fibroblasts. In : Arachidonic Acid : Sources, Biosynthesis and Health Effects2014
- Author(s)
  Kusunoki N, Kojima F, Kawai S(O'Keefe JM (Ed))
- Publisher
  Nova Science Publishers, Inc., New York(ISBN:978-1-63117-619-7)
- Data Source
  KAKENHI-PROJECT-23591449
[Book] Arachidonic Acid: Sources, Biosynthesis and Health Effects.2014
- Author(s)
  Kusunoki N, Kojima F, Kawai S.
- Publisher
  Nova Science Publishers, Inc.
- Data Source
  KAKENHI-PROJECT-26461477
[Book] Chapter 6: Effects of adipokines on prostaglandin E2 production by rheumatoid synovial fibroblasts. In: O’Keefe JM (Ed) Arachidonic Acid: Sources, Biosynthesis and Health Effects.2014
- Author(s)
  Kusunoki N, Kojima F, Kawai S. (Chapter 6)
- Publisher
  Nova Science Publishers, Inc.
- Data Source
  KAKENHI-PROJECT-23591449
[Book] Adiponectin enhances inflammation in rheumatoid synovial fibroblasts and chondrocytes. In : Adipokines2011
- Author(s)
  Kusunoki N, Kitahara K, Kawai S( Preedy VR and Hunter RJ (Eds))
- Publisher
  CRC Press, Jersey
- Data Source
  KAKENHI-PROJECT-23591449
[Book] Adiponectin enhances inflammation in rheumatoid synovial fibroblasts and chondrocytes. In: Preedy VR and Hunter RJ (Eds) Adipokines.2011
- Author(s)
  Kusunoki N, Kitahara K, Kawai S
- Publisher
  CRC Press
- Data Source
  KAKENHI-PROJECT-23591449
[Book] ポケット版やさしいリウマチ治療薬の基礎知識2008
- Author(s)
  川合真一著
- Total Pages
  125
- Publisher
  医薬ジャーナル社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590477
[Book] ササッとわかる最新「関節リウマチ」治療法2008
- Author(s)
  川合眞一著
- Total Pages
  110
- Publisher
  講談社
- Data Source
  KAKENHI-PROJECT-20591177
[Book] ポケット版やさしいリウマチ治療薬の基礎知識2008
- Author(s)
  川合眞一著
- Total Pages
  125
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-17590477
[Book] やさしいリウマチ治療薬の基礎知識2006
- Author(s)
  川合真一著
- Total Pages
  78
- Publisher
  医薬ジャーナル社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590477
[Book] 抗リウマチ薬の選び方と使い方2006
- Author(s)
  川合真一編集
- Total Pages
  120
- Publisher
  南江堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590477
[Book] 抗リウマチ薬の選び方と使い方2006
- Author(s)
  川合眞一(編集)
- Total Pages
  120
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-17590477
[Book] 抗リウマチ薬Q&A2006
- Author(s)
  川合真一, 他(3名)編集
- Total Pages
  207
- Publisher
  日本医学出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] Serum resistin level and progression of atherosclerosis during glucocorticoid therapy for systemic autoimmune diseases.2016
- Author(s)
  Tanaka N, Masuoka S, Kusunoki N, Nanki T, Kawai S.
- Journal Title
  
  Metabolites.
  
  Volume: 6 Issue: 3 Pages: 28-28
- DOI
  10.3390/metabo6030028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461477
[Journal Article] Absence of ethnic differences in the pharmacokinetics of moxifloxacin, simvastatin, and meloxicam among three east Asian populations and Caucasians.2016
- Author(s)
  Hasunuma T, Tohkin M, Kaniwa N, Jang IJ, Cui Y, Kaneko M, Saito Y, Takeuchi M, Watanabe H, Yamazoe Y, Uyama Y, Kawai S.
- Journal Title
  
  British Journal of Clinical Pharmacology
  
  Volume: in press Issue: 6 Pages: 1078-1090
- DOI
  10.1111/bcp.12884
- Open Access
- Data Source
  KAKENHI-PROJECT-26461477
[Journal Article] The growth factor midkine may play a pathophysiological role in rheumatoid arthritis.2016
- Author(s)
  Shindo E, Nanki T, Kusunoki N, Shikano K, Kawazoe M, Sato H, Kaneko K, Muraoka S, Kaburaki M, Akasaka Y, Shimada H, Hasunuma T, Kawai S.
- Journal Title
  
  Modern Rheumatology
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-26461477
[Journal Article] Folylpolyglutamate synthase is a major determinant of intracellular methotrexate polyglutamates in patients with rheumatoid arthritis.2016
- Author(s)
  Yamamoto T, Shikano K, Nanki T, Kawai S.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 149-150
- DOI
  10.1038/srep35615
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461477, KAKENHI-PROJECT-19K10017
[Journal Article] Efficacy of vitamin K2 for glucocorticoid-induced osteoporosis in patients with systemic autoimmune diseases.2016
- Author(s)
  Shikano K, Kaneko K, Kawazoe M, Kaburaki M, Hasunuma T, Kawai S.
- Journal Title
  
  Internal Medicine
  
  Volume: in press
- NAID
  130005254821
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461477
[Journal Article] Apparent hypothalamic-pituitary-adrenal axis suppression via reduction of interleukin-6 by glucocorticoid therapy in systemic autoimmune diseases.2016
- Author(s)
  Fujio N, Masuoka S, Shikano K, Kusunoki N, Nanki T, Kawai S.
- Journal Title
  
  PLoS ONE.
  
  Volume: 11 Issue: 12 Pages: e0167854-e0167854
- DOI
  10.1371/journal.pone.0167854
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461477
[Journal Article] Longterm Safety and Efficacy of Subcutaneous Tocilizumab Monotherapy: Results from the 2-year Open-label Extension of the MUSASHI Study.2015
- Author(s)
  Ogata A, Amano K, Dobashi H, Inoo M, Ishii T, Kasama T, Kawai S, Kawakami A, Koike T, Miyahara H, Miyamoto T, Munakata Y, Murasawa A, Nishimoto N, Ogawa N, Ojima T, Sano H, Shi K, Shono E, Suematsu E, Takahashi H, Tanaka Y, Tsukamoto H, Nomura A and Investigators MS.
- Journal Title
  
  The Journal of rheumatology
  
  Volume: 42 Issue: 5 Pages: 799-809
- DOI
  10.3899/jrheum.140665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591465, KAKENHI-PROJECT-26461477
[Journal Article] Pharmacokinetics, efficacy and safety profiles of etanercept monotherapy in Japanese patients with rheumatoid arthritis: review of seven clinical trials.2015
- Author(s)
  Takeuchi T, Miyasaka N, Kawai S, Sugiyama N, Yuasa H, Yamashita N, Sugiyama N, Wagerle LC, Vlahos B, Wajdula J
- Journal Title
  
  Modern Rheumatology
  
  Volume: 25 Issue: 2 Pages: 173-186
- DOI
  10.3109/14397595.2014.914014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461477
[Journal Article] Post-marketing surveillance of the safety and effectiveness of tacrolimus in 3,267 Japanese patients with rheumatoid arthritis2014
- Author(s)
  Takeuchi T, Kawai S, Yamamoto K, Harigai M, Ishida K, Miyasaka N
- Journal Title
  
  Mod Rheumatol
  
  Volume: 24(1) Issue: 1 Pages: 8-16
- DOI
  10.3109/14397595.2013.854074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591449
[Journal Article] – A 3-Year Nationwide Comparative Observational Study in Japan (ACCEPT) –2014
- Author(s)
  Hirayama A, Tanahashi N, Daida H, Ishiguro N, Chachin M, Sugioka T, Kawai S
- Journal Title
  
  Circ J
  
  Volume: 78 Issue: 1 Pages: 194-205
- DOI
  10.1253/circj.CJ-12-1573
- NAID
  130003382167
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591449
[Journal Article] A feasibility study assessing tolerability of daily versus twice weekly trimethoprim-sulfamethoxazole regimen for prophylaxis against Pneumocystis pneumonia in patients with systemic autoimmune diseases on glucocorticoid therapy.2014
- Author(s)
  Yamamoto T, Hasunuma T, Takagi K, Akimoto K, Shikano K, Kaburaki M, Muraoka S, Kitahara K, Tanaka N, Kaneko K, Kusunoki Y, Endo H, Kawai S.
- Journal Title
  
  Jpn J Clin Pharmacol Ther.
  
  Volume: 45 Pages: 89-92
- NAID
  130004679387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461477
[Journal Article] Leptin stimulates interleukin-6 production via janus kinase 2/signal transducer and activator of transcription 3 in rheumatoid synovial fibroblasts.2013
- Author(s)
  Muraoka S, Kusunoki N, Takahashi H, Tsuchiya K, Kawai S.
- Journal Title
  
  Clin Exp Rheumatol.
  
  Volume: 31 Pages: 589-595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591449
[Journal Article] Leptin stimulates interleukin-6 production via janus kinase 2/signal transducer and activator of transcription 3 in rheumatoid synovial fibroblasts2013
- Author(s)
  Muraoka S, Kusunoki N, Takahashi H, Tsuchiya K, Kawai S
- Journal Title
  
  Clin Exp Rheumatol
  
  Volume: 31(4)(Epub 2013 Apr 22, PMID:23622344) Pages: 589-595
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/23622344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591449
[Journal Article] Expression and function of chemerin in the synovial tissues of patients with rheumatoid arthritis2013
- Author(s)
  Kaburaki M, Kusunoki N, Takahashi H, Tsuchiya K, Kawai S, Endo H
- Journal Title
  
  J Med Soc Toho
  
  Volume: 60(1) Pages: 3-14
- NAID
  120006412174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591449
[Journal Article] Leptin stimulates interleukin-6 production via janus kinase 2/signal transducer and activator of transcription 3 in rheumatoid synovial fibroblasts.2013
- Author(s)
  Muraoka S, Kusunoki N, Takahashi H, Tsuchiya K, Kawai S
- Journal Title
  
  Clin Exp Rheumatol.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591449
[Journal Article] Prevention of joint destruction by tacrolimus in patients with early rheumatoid arthritis: a post hoc analysis of a double-blind, randomized, placebo-controlled study.2013
- Author(s)
  Tanaka Y, Kawai S, Takeuchi T, Yamamoto K, Miyasaka N
- Journal Title
  
  Mod Rheumatol.
  
  Volume: in press Pages: 1045-1052
- DOI
  10.1007/s10165-012-0817-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591449
[Journal Article] Resistin is associated with inflammation process in systemic autoimmune diseases under glucocorticoid therapy: comparison with leptin and adiponectin.2013
- Author(s)
  Tanaka N, Kusunoki N, Kusunoki Y, Hasunuma T, Kawai S.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 23 Issue: 1 Pages: 8-18
- DOI
  10.1007/s10165-012-0623-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591449
[Journal Article] Post-marketing surveillance of the safety and effectiveness of tacrolimus in 3,267 Japanese patients with rheumatoid arthritis.2013
- Author(s)
  Takeuchi T, Kawai S, Yamamoto K, Harigai M, Ishida K, Miyasaka N
- Journal Title
  
  Mod Rheumatol.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591449
[Journal Article] The role of the Japanese society of clinical pharmacology and therapeutics in the transition of clinical studies in Japan2013
- Author(s)
  Nakano M, Iijima H, Takada K, Uchida N, Kawai S, Kagiya T, Kumagai Y
- Journal Title
  
  JMAJ
  
  Volume: 56(2) Pages: 115-117
- URL
  http://www.med.or.jp/english/journal/pdf/2013_02/115_117.pdf
- Data Source
  KAKENHI-PROJECT-23591449
[Journal Article] Expression and function of chemerin in the synovial tissues of patients with rheumatoid arthritis.2013
- Author(s)
  Kaburaki M, Kusunoki N, Takahashi H, Tsuchiya K, Kawai S, Endo H.
- Journal Title
  
  J Med Soc Toho.
  
  Volume: 60 Pages: 3-14
- NAID
  120006412174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591449
[Journal Article] Changes of serum soluble receptor activator for nuclear factor κB ligand after glucocorticoid therapy reflect regulation of its expression by osteoblasts.2012
- Author(s)
  Kaneko K, Kusunoki N, Hasunuma T, Kawai S
- Journal Title
  
  J Clin Endocrinol Metab.
  
  Volume: 97 Issue: 10 Pages: E1909-E1917
- DOI
  10.1210/jc.2012-1971
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591449
[Journal Article] Tacrolimus down-regulates chemokine expressions on rheumatoid synovial fibroblasts: screening by a DNA microarray.2012
- Author(s)
  Kitahara K, Kusunoki N, Takahashi H, Tsuchiya K, Kawai S
- Journal Title
  
  Inflamm Res.
  
  Volume: 61 Issue: 12 Pages: 1385-1394
- DOI
  10.1007/s00011-012-0541-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591449
[Journal Article] Efficacy, pharmacokinetics, and safety of adalimumab in pediatric patients with juvenile idiopathic arthritis in Japan.2012
- Author(s)
  Imagawa T, Takei S, ---, Kawai S, Yokota S
- Journal Title
  
  Clin Rheumatol.
  
  Volume: 31 Issue: 12 Pages: 1713-1721
- DOI
  10.1007/s10067-012-2082-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591449, KAKENHI-PROJECT-23591546
[Journal Article] Serum adipokine profiles in Kawasaki disease2012
- Author(s)
  Kemmotsu Y, Saji T, Kusunoki N, Tanaka N, Nishimura C, Ishiguro A, Kawai S
- Journal Title
  
  Mod Rheumatol
  
  Volume: 22(1) Issue: 1 Pages: 66-72
- DOI
  10.1007/s10165-011-0468-x
- NAID
  10030206877
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591449
[Journal Article] Humanized anti-interleukin-6-receptor antibody (tocilizumab) monotherapy is more effective in slowing radiographic progression in patients with rheumatoid arthritis at high baseline risk for structural damage evaluated with levels of biomarkers, radiography, and BMI : data from the SAMURAI study.2011
- Author(s)
  Hashimoto J, Kawai S, et al.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 21 Pages: 10-15
- NAID
  10029361106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Effects of surgery and chronic disease states on the concentrations and phenotype distribution of α1-acid glycoprotein: studies in patients with breast cancer and patients with chronic inflammatory disease.2011
- Author(s)
  Hanada K, Yamanaka E, Yamamoto N, Minami H, Kawai S, Sasaki Y, Ogata H.
- Journal Title
  
  Int J Clin Pharmacol Ther.
  
  Volume: 49 Issue: 07 Pages: 415-421
- DOI
  10.5414/cp201539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591449
[Journal Article] Clinical and radiological features of acute-onset diffuse interstitial lung diseases in patients with rheumatoid arthritis receiving treatment with biological agents : importance of pneumocystis pneumonia in Japan revealed by a multicenter study.2011
- Author(s)
  Kameda H, Tokuda H, Sakai F, Johkoh T, Mori S, Yoshida Y, Takayanagi N, Taki H, Hasegawa Y, Hatta K, Yamanaka H, Dohi M, Hashimoto S, Yamada H, Kawai S, Takeuchi T, Tateda K, Goto H.
- Journal Title
  
  Intern Med. 50
  
  Pages: 305-313
- NAID
  130000413114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Potential roles of microsomal prostaglandin E synthase-1 in rheumatoid arthritis.2011
- Author(s)
  Kojima F, Matnani RG, Kawai S, Ushikubi F, Crofford LJ
- Journal Title
  
  Inflamm Regen.
  
  Volume: 31 Pages: 157-166
- NAID
  130004943782
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591449
[Journal Article] anti-interleukin-6-receptor antibody (tocilizumab) monotherapy is more effective in slowing radiographic progression in patients with rheumatoid arthritis at high baseline risk for structural damage evaluated with levels of biomarkers, radiography, and BMI : data from the SAMURAI study.2011
- Author(s)
  Hashimoto J, Garnero P, van der Heijde D, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Yoshikawa H, Nishimoto N. Humanized
- Journal Title
  
  Mod Rheumatol. 21
  
  Pages: 10-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Clinical and radiological features of acute-onset diffuse interstitial lung diseases in patients with rheumatoid arthritis receiving treatment with biological agents importance of pneumocystis pneumonia in Japan revealed by a multicenter study.2011
- Author(s)
  Kameda H, Kawai S, et al.
- Journal Title
  
  Intern Med.
  
  Volume: 50 Pages: 305-313
- NAID
  130000413114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Elevated serum levels of resistin, leptin, and adiponectin are associated with C-reactive protein and also other clinical conditions in rheumatoid arthritis.2011
- Author(s)
  Yoshino T, Kusunoki N, Tanaka N, Kaneko K, Kusunoki Y, Endo H, Hasunuma T, Kawai S.
- Journal Title
  
  Intern Med. 50
  
  Pages: 269-275
- NAID
  130000413109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Efficacy and safety of additional use of tacrolimus in early rheumatoid arthritis patients with inadequate response to DMARDs - a multicenter, double-blind, parallel-group trial2011
- Author(s)
  Kawai S, Takeuchi T, Yamamoto K, Tanaka Y, Miyasaka N
- Journal Title
  
  Mod Rheumatol
  
  Volume: 21(5) Issue: 5 Pages: 458-468
- DOI
  10.1007/s10165-011-0425-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591449
[Journal Article] Elevated serum levels of resistin, leptin, and adiponectin are associated with C-reactive protein and also other clinical conditions in rheumatoid arthritis.2011
- Author(s)
  Yoshino T, Kawai S, et al.
- Journal Title
  
  Intern Med.
  
  Volume: 50 Pages: 269-275
- NAID
  130000413109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Efficacy and safety of additional use of tacrolimus in early rheumatoid arthritis patients with inadequate response to DMARDs-a multicenter, double-blind, parallel-group trial.2011
- Author(s)
  Kawai S, et al
- Journal Title
  
  Mod Rheumatol.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Exacerbation of adult-onset Still's disease, possibly related to elevation of serum tumor necrosis factor-α after etanercept administration.2010
- Author(s)
  Kaneko K, Kaburaki M, Muraoka S, Tanaka N, Yamamoto T, Kusunoki Y, Abe H, Endo H, Kawai S.
- Journal Title
  
  Int J Rheum Dis. 13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Adiponectin stimulates prostaglandin E2 production in rheumatoid synovial fibroblasts.2010
- Author(s)
  Kusunoki N, Kawai S, et al.
- Journal Title
  
  Arthritis Rheum.
  
  Volume: 62 Pages: 1641-1649
- NAID
  130006950120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Efficacy and safety of ketoprofen patch in patients with rheumatoid arthritis : a randomized, double-blind, placebo-controlled study.2010
- Author(s)
  Kawai S, Uchida E, Kondo M, Ohno S, Obata J, Nawata Y, Sugimoto K, Oribe M, Nagaya I.
- Journal Title
  
  J Clin Pharmacol. 50
  
  Pages: 1171-1179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Systemic lupus erythematosus complicated by recurrent pneumothorax : case report and literature review.2010
- Author(s)
  Tanaka N, Kawai S, et al.
- Journal Title
  
  Jpn J Clin Immunol.
  
  Volume: 33 Pages: 162-168
- NAID
  10026543359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Adiponectin stimulates prostaglandin E_2 production in rheumatoid synovial fibroblasts.2010
- Author(s)
  Kusunoki N, Kitahara K, Kojima F, Tanaka N, Kaneko K, Endo H, Suguro T, Kawai S.
- Journal Title
  
  Arthritis Rheum. 62
  
  Pages: 1641-1649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Systemic lupus erythematosus complicated by recurrent pneumothorax : case report and literature review.2010
- Author(s)
  Tanaka N, Kusunoki Y, Kaneko K, Yamamoto T, Kaburaki M, Muraoka S, Abe H, Endo H, Sato D, Homma S, Shibuya K, Kawai S.
- Journal Title
  
  Jpn J Clin Immunol. 33
  
  Pages: 162-168
- NAID
  10026543359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Exacerbation of adult-onset Still's disease, possibly related to elevation of serum tumor necrosis factor after etanercept administration.2010
- Author(s)
  Kaneko K, Kawai S, et al.
- Journal Title
  
  Int J Rheum Dis.
  
  Volume: 13 Pages: 67-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Clinical activities after 12 weeks of treatment with non-biologics in early rheumatoid arthritis may predict the articular destruction 2 years later.2010
- Author(s)
  Ichikawa Y, Saito T, Yamanaka H, Akizuki M, Kondo H, Kobayashi S, Oshima H, Kawai S, et al.
- Journal Title
  
  J Rheumatol. 37
  
  Pages: 723-729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Clinical activities after 12 weeks of treatment with non-biologics in early rheumatoid arthritis may predict the articular destruction 2 years later.2010
- Author(s)
  Ichikawa Y, Kawai S, et al
- Journal Title
  
  J Rheumatol.
  
  Volume: 37 Pages: 723-729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Efficacy and safety of ketoprofen patch in patients with rheumatoid arthritis : a randomized, double-blind, placebo controlled study.2010
- Author(s)
  Kawai S, et al.
- Journal Title
  
  J Clin Pharmacol.
  
  Volume: 50 Pages: 1171-1179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Japan College of Rheumatology 2009 guidelines for the use of tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, in rheumatoid arthritis2009
- Author(s)
  Koike R, Harigai M, Atsumi T, Amano K, Kawai S, Saito K, Saito T, Yamamura M, Matsubara T, Miyasaka N.
- Journal Title
  
  Mod Rheumatol 19(4)
  
  Pages: 351-357
- NAID
  10025113303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Preliminary study to identify the predictive factors for the response to methotrexate therapy in patients with rheumatoid arthritis.2009
- Author(s)
  Inoue S, Hashiguchi M, Takagi K, Kawai S, Mochizuki M.
- Journal Title
  
  Yakugaku Zasshi. 129
  
  Pages: 843-849
- NAID
  130000135978
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Pharmacokinetic study and Fcγ receptor gene analysis in 2 patients with rheumatoid arthritis controlled by low-dose infliximab.2009
- Author(s)
  Nishio S, Yamamoto T, Kaneko K, Tanaka-Matsumoto N, Muraoka S, Kaburaki M, Kusunoki Y, Takagi K, Kawai S.
- Journal Title
  
  Mod Rheumatol. 19
  
  Pages: 329-333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Efficacy and safety of tacrolimus for lupus nephritis : a placebo-controlled double-blind multicenter study2009
- Author(s)
  Miyasaka N, Kawai S, Hashimoto H.
- Journal Title
  
  Mod Rheumatol 19(6)
  
  Pages: 606-615
- NAID
  10027167694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Prostaglandin E_2 differentially modulates proinflammatory/prodestructive effects of TNF-alpha on synovial fibroblasts via specific E prostanoid receptors/cAMP2009
- Author(s)
  Kunisch E, Jansen A, Kojima F, Loffler I, Kapoor M, Kawai S, Rubio I, Crofford LJ, Kinne RW.
- Journal Title
  
  J Immunol 183(2)
  
  Pages: 1328-1336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Japan College of Rheumatology 2009 guidelines for the use of tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, in rheumatoid arthritis.2009
- Author(s)
  Koike R, Harigai M, Atsumi T, Amano K, Kawai S, Saito K, Saito T, Yamamura M, Matsubara T, Miyasaka N.
- Journal Title
  
  Mod Rheumatol. 19
  
  Pages: 351-357
- NAID
  10025113303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Erythrocyte methotrexate- polyglutamate assay using fluorescence polarization immunoassay technique : application to the monitoring of patients with rheumatoid arthritis2009
- Author(s)
  Inoue S, Hashiguchi M, Kawai S, Mochizuki M.
- Journal Title
  
  Yakugaku Zasshi 129(8)
  
  Pages: 1001-1005
- NAID
  130000135996
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] A combination of biochemical markers of cartilage and bone turnover, radiographic damage and body mass index to predict the progression of joint destruction in patients with rheumatoid arthritis treated with disease-modifying anti-rheumatic drugs.2009
- Author(s)
  Hashimoto J, Garnero P, van der Heijde D, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Yoshikawa H, Nishimoto N.
- Journal Title
  
  Mod Rheumatol. 19
  
  Pages: 273-282
- NAID
  10025112961
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Prostaglandin E_2 differentially modulates proinflammatory/prodestructive effects of TNF-alpha on synovial fibroblasts via specific E prostanoid receptors/cAMP.2009
- Author(s)
  Kunisch E, Jansen A, Kojima F, Loffler I, Kapoor M, Kawai S, Rubio I, Crofford LJ, Kinne RW.
- Journal Title
  
  J Immunol. 183
  
  Pages: 1328-1336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Prostaglandin E_2 activates RAP1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts : Involvement of EPAC1 and PKA.2009
- Author(s)
  Kojima F, Kapoor M, Kawai S, Yang L, Aronoff DM, Crofford LJ.
- Journal Title
  
  Prostaglandins Other Lipid Mediat. 89
  
  Pages: 26-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Prostaglandin E_2 activates RAP1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts : Involvement of EPAC1 and PKA2009
- Author(s)
  Kojima F, Kapoor M, Kawai S, Yang L, Aronoff DM, Crofford LJ.
- Journal Title
  
  Prostaglandins Other Lipid Medial 89(1-2)
  
  Pages: 26-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Preliminary study to identify the predictive factors for the response to methotrexate therapy in patients with rheumatoid arthritis2009
- Author(s)
  Inoue S, Hashiguchi M, Takagi K, Kawai S, Mochizuki M.
- Journal Title
  
  Yakugaku Zasshi 129(7)
  
  Pages: 843-849
- NAID
  130000135978
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Tacrolimus therapy for systemic lupus erythematosus without renal involvement : a preliminary retrospective study.2009
- Author(s)
  Kusunoki Y, Tanaka N, Kaneko K, Yamamoto T, Endo H, Kawai S.
- Journal Title
  
  Mod Rheumatol. 19
  
  Pages: 616-621
- NAID
  10027167729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Long-term safety and efficacy of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study) : evidence of safety and efficacy in a 5-year extension study.2009
- Author(s)
  Nishimoto N, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Azuma J.
- Journal Title
  
  Ann Rheum Dis. 68
  
  Pages: 1580-1584
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI) : significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy.2009
- Author(s)
  Nishimoto N, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Azuma J, Kishimoto T.
- Journal Title
  
  Mod Rheumatol 19
  
  Pages: 12-19
- NAID
  10025111886
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Long-term safety and efficacy of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis(the STREAM study) : evidence of safety and efficacy in a 5-year extension study2009
- Author(s)
  Nishimoto N, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Azuma J.
- Journal Title
  
  Ann Rheum Dis 68(10)
  
  Pages: 1580-1584
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] A combination of biochemical markers of cartilage and bone turnover, radiographic damage and body mass index to predict the progression of joint destruction in patients with rheumatoid arthritis treated with disease-modifying anti-rheumatic drugs2009
- Author(s)
  Hashimoto J, Garnero P, van der Heijde D, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Yoshikawa H, Nishimoto N.
- Journal Title
  
  Mod Rheumatol 19(3)
  
  Pages: 273-282
- NAID
  10025112961
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Adiponectin stimulates IL-8 production by rheumatoid synovial fibroblasts.2009
- Author(s)
  Kitahara K, Kusunoki N, Kakiuchi T, Suguro T, Kawai S.
- Journal Title
  
  Biochem Biophys Res Commun. 378
  
  Pages: 218-223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Tacrolimus therapy for systemic lupus erythematosus without renal in volvement : a preliminary retrospective study2009
- Author(s)
  Kusunoki Y, Tanaka N, Kaneko K, Yamamoto T, Endo H, Kawai S.
- Journal Title
  
  Mod Rheumatol 19(6)
  
  Pages: 616-621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Erythrocyte methotrexate-polyglutamate assay using fluorescence polarization immunoassay technique : application to the monitoring of patients with rheumatoid arthritis.2009
- Author(s)
  Inoue S, Hashiguchi M, Kawai S, Mochizuki M.
- Journal Title
  
  Yakugaku Zasshi. 129
  
  Pages: 1001-1005
- NAID
  130000135996
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Efficacy and safety of tacrolimus for lupus nephritis : a placebo-controlled double-blind multicenter study.2009
- Author(s)
  Miyasaka N, Kawai S, Hashimoto H.
- Journal Title
  
  Mod Rheumatol. 19
  
  Pages: 606-615
- NAID
  10027167694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Safety of long-term tacrolimus therapy for rheumatoid arthritis:an open-label uncontrolled study in non-elderly patients2008
- Author(s)
  Kawai S, et. al.
- Journal Title
  
  Mod Rheumatol (in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] Safety of long-term tacrolimus therapy for rheumatoid arthritis : an open-label uncontrolled study in non-elderly patients.2008
- Author(s)
  Kawai S, Tanaka K, Ohno I, Utsunomiya K, Seino Y.
- Journal Title
  
  Mod Rheumatol. 18
  
  Pages: 345-353
- NAID
  10021946870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Pro-apoptotic effect of nonsteroidal anti-inflammatory drugs on synovial fibroblasts.2008
- Author(s)
  Kusunoki N, Yamazaki R, Kawai S.
- Journal Title
  
  Mod Rheumatol. 18
  
  Pages: 542-551
- NAID
  10025111417
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Clinical value of second and third generation assays of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis.2008
- Author(s)
  Kitahara K, Takagi K, Kusunoki Y, Nishio S, Nozaki T, Inomata H, Takei M, Sawada S, Kawai S.
- Journal Title
  
  Ann Rheum Dis. 67
  
  Pages: 1059-1060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Safty of long-term tacrolimus therapy for rheumatoid arthritis : an open-lebel, uncontrolled study in non-elderly patients.2008
- Author(s)
  Kawai S, et al
- Journal Title
  
  Mod Rheumatol 18
  
  Pages: 345-353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Safety profile of tacrolimus in patients with rheumatoid arthritis.2008
- Author(s)
  Akimoto K, Kusunoki Y, Nishio S, Takagi K, Kawai S.
- Journal Title
  
  Clin Rheumatol. 27
  
  Pages: 1393-1397
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591177
[Journal Article] Safety of long-term tacrolimus therapy for rheumatoid arthritis : an open-label uncontrolled study in non-elderly patients2008
- Author(s)
  Kawai, S., et. al.
- Journal Title
  
  Mod Rheumatol (in press)
- NAID
  10021946870
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] Safety of long-term tacrolimus therapy for rheumatoid arthritis: an open-label uncontrolled study in non-elderly patients.2008
- Author(s)
  Kawai S, et. al.
- Journal Title
  
  Mod Rheumatol (in press)
- NAID
  10021946870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] Cyclosporine and tacrolimus for the treatment of rheumatoid arthritis2007
- Author(s)
  Kitahara, Kawai S
- Journal Title
  
  Curr Opin Rheumatol 19(3)
  
  Pages: 238-245
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] Cyclosporine and tacrolimus for the treatment of rheumatoid arthritis.2007
- Author(s)
  Kitahara K & Kawai S
- Journal Title
  
  Curr Opin Rheumatol 19(3)
  
  Pages: 238-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] Cyclosporine and tacrolimus for the treatment of rheumatoid arthritis2007
- Author(s)
  Kitahara, K., Kawai, S
- Journal Title
  
  Curr Opin Rheumatol 19(3)
  
  Pages: 238-245
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] The comparability of etanercept pharmacokinetics in healthy Japanese and American subjects2006
- Author(s)
  Kawai, S., et. al.
- Journal Title
  
  J Clin Pharmacol 46(4)
  
  Pages: 418-423
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] Safety of tacrolimus,an immunosuppressive agent,in the treatment of rheumatoid arthritis in elderly patients2006
- Author(s)
  Kawai S, Yamamoto K
- Journal Title
  
  Rheumatology(Oxford) 45(4)
  
  Pages: 441-444
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] Safety of tacrolimus, an immunosuppressive agent, in the treatment of rheumatoid arthritis in elderly patients2006
- Author(s)
  Kawai, S., Yamamoto, K
- Journal Title
  
  Rheumatology (Oxford) 45(4)
  
  Pages: 441-444
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] The comparability of etanercept pharmacokinetics in healthy Japanese and American subjects2006
- Author(s)
  Kawai S, et. al.
- Journal Title
  
  J Clin Pharmacol 46(4)
  
  Pages: 418-423
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] The comparability of etanercept pharmacokinetics in healthy Japanese and American subjects.2006
- Author(s)
  Kawai S, et al.
- Journal Title
  
  J Clin Pharmacol (in press)
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] Comparison of tacrolimus and mizoribine in a randomized, double-blind controlled study in patients with rheumatoid arthritis2006
- Author(s)
  Kawai, S., et. al.
- Journal Title
  
  J Rheumatol 33(11)
  
  Pages: 2153-2161
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] The comparability of etanercept pharmacokinetics in healthy Japanese and American subjects.2006
- Author(s)
  Kawai S, et al.
- Journal Title
  
  J Clin Pharmacol 46(4)
  
  Pages: 418-423
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] Safety of tacrolimus, an immunosuppressive agent, in the treatment of theumatoid arthritis in elderly patients.2006
- Author(s)
  Kawai S, Yamamoto K
- Journal Title
  
  Rheumatology (Oxford) 45(4)
  
  Pages: 441-444
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] Comparison of tacrolimus and mizoribine in a randomized,double-blind controlled study in patients with rheumatoid arthritis2006
- Author(s)
  Kawai S, et. al.
- Journal Title
  
  J Rheumatol 33(11)
  
  Pages: 2153-2161
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] Brain-derived neurotrophic factor bound with lecithin derivative showed a markedly enhanced pharmacological potency due to its potent cell membrane affinity followed by prolonged MAPK activation.2005
- Author(s)
  Igarashi R, Nakayama T, Takenaga M, Ichinohe M, Yamaguchi Y, Matsumoto K, Kitagawa A, Nakamura N, Kawai S, Nakagawa T, Taiji M, Nakayama C, Mizushima Y.
- Journal Title
  
  J Control Release 102(2)
  
  Pages: 463-473
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Recent advances in nonsteroidal anti-inflammatory drugs2005
- Author(s)
  Kawai, S., et. al.
- Journal Title
  
  Allergol Int 54(2)
  
  Pages: 209-215
- NAID
  10015655408
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] Recent advances in nonsteroidal anti-inflammatory drugs.2005
- Author(s)
  Kawai S, et al.
- Journal Title
  
  Allergol Int 54(2)
  
  Pages: 209-215
- NAID
  10015655408
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] Recent advances in nonsteroidal anti-inflammatory drugs2005
- Author(s)
  Kawai S, et. al.
- Journal Title
  
  Allergol Int 54(2)
  
  Pages: 209-215
- NAID
  10015655408
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] Safety of tacrolimus, an immunosuppressive agent, in the treatment of rheumatoid arthritis in elderly patients.2005
- Author(s)
  Kawai S, et al.
- Journal Title
  
  Rheumatology (Oxford) Nov 1(Epub)
- Data Source
  KAKENHI-PROJECT-17590477
[Journal Article] Kusunoki N. Recent advances in nonsteroidal anti-inflammatory drugs.2005
- Author(s)
  Kawai S. et al.
- Journal Title
  
  Allergol Int (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Recent advances in nonsteroidal anti-inflammatory drugs.2005
- Author(s)
  Kawai S, et al.
- Journal Title
  
  Allergol Int (in press)
- NAID
  10015655408
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Triptolide, an active compound identified in a traditional Chinese herb, induces apoptosis of rheumatoid synovial fibroblasts.2004
- Author(s)
  Kusunoki N, Yamazaki R, Kitasato H, Beppu M, Aoki H, Kawai S.
- Journal Title
  
  BMC Pharmacol (http://www.biomedcentral.com/1471-2210/4/2) 4(1):2
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Optimum formulation for sustained-release insulin.2004
- Author(s)
  Takenaga M, Yamaguchi Y, Kitagawa A, Ogawa Y, Kawai S, Mizushima Y, Igarashi R.
- Journal Title
  
  Int J Pharm 271(1-2)
  
  Pages: 85-94
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody : A multicenter, double-blind, placebo-controlled trial.2004
- Author(s)
  Nishimoto N, Yoshizaki K, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Hashimoto J, Azuma J, Kishimoto T.
- Journal Title
  
  Arthritis Rheum 50(6)
  
  Pages: 1761-1769
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis.2004
- Author(s)
  Kojima F, Naraba H, Miyamoto S, Beppu M, Aoki H, Kawai S.
- Journal Title
  
  Arthritis Res Ther 6(4)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] A single treatment with microcapsules containing a CXCR4 antagonist suppresses pulmonary metastasis of murine melanoma.2004
- Author(s)
  Takenaga M, Tamamura H, Hiramatsu K, Nakamura N, Yamaguchi Y, Kitagawa A, Kawai S, Nakashima H, Fujii N, Igarashi R.
- Journal Title
  
  Biochem Biophys Res Commun 320(1)
  
  Pages: 226-232
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Prostaglandin E2 is an enhancer for interleukin-16-induced expression of membrane-associated prostaglandin E synthase in rheumatoid synovial fibroblasts.2003
- Author(s)
  Kojima F, Naraba H, Sasaki Y, Beppu M, Aoki H, Kawai S.
- Journal Title
  
  Arthritis Rheum 48(10)
  
  Pages: 2819-2828
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Current drug therapy for rheumatoid arthritis.2003
- Author(s)
  Kawai S.
- Journal Title
  
  J Orthop Sci 8(2)
  
  Pages: 259-263
- NAID
  50000783984
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Current drug therapy for rheumatoid arthritis.2003
- Author(s)
  Kawai S
- Journal Title
  
  J Orthop Sci 8(2)
  
  Pages: 259-263
- NAID
  50000783984
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Inhibition of monosodium urate monohydrate crystal-induced acute inflammation by retrovirally transfected prostaglandin D synthase.2003
- Author(s)
  Murakami Y, Akahoshi T, Hayashi I, Endo H, Hashimoto A, Kono S, Kondo H, Kawai S, Inoue M, Kitasato H.
- Journal Title
  
  Arthritis Rheum 48(10)
  
  Pages: 2931-2941
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Retrovirally introduced prostaglandin D2 synthase suppresses lung injury induced by bleomycin.2003
- Author(s)
  Ando M, Murakami Y, Kojima F, Endo H, Kitasato H, Hashimoto A, Kobayashi H, Majima M, Inoue M, Kondo H, Kawai S, Hayashi I.
- Journal Title
  
  Am J Respir Cell Mol Biol 28(5)
  
  Pages: 582-591
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Plasma leptin levels in patients with burn injury : a preliminary report.2003
- Author(s)
  Kino Y, Kato M, Ikehara Y, Asanuma Y, Akashi K, Kawai S.
- Journal Title
  
  Burns 29(5)
  
  Pages: 449-453
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Effects of rebamipide, a gastro-protective drug on the Helicobacter pylori status and inflammation in the gastric mucosa of patients with gastric ulcer : a randomized double-blind placebo-controlled multicentre trial.2003
- Author(s)
  Fujioka T, Arakawa T, Shimoyama T, Yoshikawa T, Itoh M, Asaka M, Ishii H, Kuwayama H, Sato R, Kawai S, Takemoto T, Kobayashi K.
- Journal Title
  
  Aliment Pharmacol Ther 18(Suppl.1)
  
  Pages: 146-152
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Nonsteroidal anti-inflammatory drugs induce apoptosis in association with activation of peroxisome proliferator-activated receptor Y in rheumatoid synovial cells.2002
- Author(s)
  Yamazaki R, Kusunoki N, Matsuzaki T, Hashimoto S, Kawai S.
- Journal Title
  
  J Pharmacol Exp Ther 302(1)
  
  Pages: 18-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Induction of apoptosis in rheumatoid synovial fibroblasts by celecoxib, but not by other selective cyclooxygenase-2 inhibitors.2002
- Author(s)
  Kusunoki N, Yamazaki R, Kawai S.
- Journal Title
  
  Arthritis Rheum 46(12)
  
  Pages: 3159-3167
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Aspirin and sodium salicylate inhibit proliferation and induce apoptosis in rheumatoid synovial cells.2002
- Author(s)
  Yamazaki R, Kusunoki N, Matsuzaki T, Hashimoto S, Kawai S.
- Journal Title
  
  J Pharm Pharmacol 54(12)
  
  Pages: 1675-1679
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Antiinflammatory effect of retrovirally transfected interleukin-10 on monosodium urate monohydrate crystal-induced acute inflammation in murine air pouches.2002
- Author(s)
  Murakami Y, Akahoshi T, Kawai S, Inoue M, Kitasato H.
- Journal Title
  
  Arthritis Rheum 46(9)
  
  Pages: 2504-2513
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Selective cyclooxygenase-2 inhibitors show a differential ability to inhibit proliferation and induce apoptosis of colon adenocarcinoma cells.2002
- Author(s)
  Yamazaki R, Kusunoki N, Matsuzaki T, Hashimoto S, Kawai S.
- Journal Title
  
  FEBS Lett 531(2)
  
  Pages: 278-284
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Coexpression of microsomal prostaglandin E synthase with cyclooxygenase-2 in human rheumatoid synovial cells.2002
- Author(s)
  Kojima F, Naraba H, Sasaki Y, Okamoto R, Koshino T, Kawai S.
- Journal Title
  
  J Rheumatol 29(9)
  
  Pages: 1836-1842
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Prostaglandin E synthase in the pathophysiology of arthritis.
- Author(s)
  Kojima F, Kato S, Kawai S.
- Journal Title
  
  Fundam Clin Pharmacol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Prostaglandin E2 production in ovarian cancer cell lines is regulated by cyclooxygenase-1, not cyclooxygenase-2.
- Author(s)
  Kino Y, Kojima F, Kiguchi K, Igarashi R, Ishizuka B, Kawai S.
- Journal Title
  
  Prostaglandins Leukot Essent Fatty Acids (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Journal Article] Recent advances in nonsteroidal anti-inflammatory drugs.
- Author(s)
  Kawai S, Kojima F, Kusunoki N.
- Journal Title
  
  Allergol Int (in press)
- NAID
  10015655408
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Patent] セレコキシブアミノアルキル誘導体2004
- Inventor(s)
  半田宏, 川合眞一, 楠夏子
- Industrial Property Rights Holder
  財)理工学振興会
- Industrial Property Number
  2004-044561
- Filing Date
  2004-02-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572167
[Presentation] バイオシミラー普及における臨床上の課題2016
- Author(s)
  川合眞一
- Organizer
  第6回レギュラトリーサイエンス学会学術大会
- Place of Presentation
  一橋大学一橋講堂（東京都千代田区）
- Year and Date
  2016-09-10
- Invited
- Data Source
  KAKENHI-PROJECT-26461477
[Presentation] ステロイドの使い方：臨床薬理と注意点2016
- Author(s)
  川合眞一
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-04-22
- Invited
- Data Source
  KAKENHI-PROJECT-26461477
[Presentation] 免疫・炎症・疼痛制御における臨床薬理学の進歩2016
- Author(s)
  川合眞一
- Organizer
  第37回日本臨床薬理学会学術総会
- Place of Presentation
  米子コンベンションセンター（鳥取県米子市）
- Year and Date
  2016-12-02
- Invited
- Data Source
  KAKENHI-PROJECT-26461477
[Presentation] Gamma-giutamyi hydrolase gene polymorphisms provide for intracellular methotrexate concentration on patients with rheumatoid arthritis.2014
- Author(s)
  Kawai S, Yamamoto T
- Organizer
  17th World Congress of Basic & Clinical Pharmacology
- Place of Presentation
  The Cape Town International Convention Centre (Convention Square, 1 Lower Long Street, Cape Town, 8001, South Africa)
- Year and Date
  2014-07-13
- Data Source
  KAKENHI-PROJECT-26461477
[Presentation] いまどきのステロイド療法2014
- Author(s)
  川合眞一
- Organizer
  第24回日本リウマチ学会北海道・東北支部学術集会
- Place of Presentation
  北海道大学医学部学友会館（北海道札幌市北区北15条西7丁目）
- Year and Date
  2014-11-22
- Invited
- Data Source
  KAKENHI-PROJECT-26461477
[Presentation] 教育講演：DMARDsの適応と使い方2014
- Author(s)
  川合眞一
- Organizer
  第58回日本リウマチ学会総会・学術集会
- Place of Presentation
  グランドプリンスホテル新高輪　国際館パミール（東京都港区高輪3-13-1）
- Year and Date
  2014-04-24
- Invited
- Data Source
  KAKENHI-PROJECT-26461477
[Presentation] メトトレキサート治療中の関節リウマチ患者における副作用の発現と、細胞内濃度および細胞内代謝関連酵素の遺伝子多型に関する研究2014
- Author(s)
  藤尾夏樹，山本竜大，楠　夏子，増岡正太郎，川添麻衣，進藤恵美子，佐藤洋志，鹿野孝太郎，鏑木　誠，村岡　成，北原加奈子，田中菜穂子，金子開知，楠　芳恵，高木賢治，蓮沼智子，遠藤平仁，川合眞一
- Organizer
  第58回日本リウマチ学会総会・学術集会
- Place of Presentation
  グランドプリンスホテル新高輪　国際館パミール（東京都港区高輪3-13-1）
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-26461477
[Presentation] アディポカインとリウマチ2011
- Author(s)
  川合眞一
- Organizer
  第55回日本リウマチ学会総会(招待講演)
- Place of Presentation
  神戸ポートピアホテル
- Data Source
  KAKENHI-PROJECT-23591449
[Presentation] History and Recent Advance in NSAID.2008
- Author(s)
  Kawai S, et al
- Organizer
  MEDICAL-EXPO 2008 in APLAR' s World. 13TH Congress of the Asia Pacific League of Associations for Rheumatology.
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-20591177
[Presentation] Current Condition of Drug Therapy for Rheumatoid Arthritis in Japan.2008
- Author(s)
  Kawai S
- Organizer
  MEDICAL-EXPO 2008 in APLAR' s World. 13TH Congress of the Asia Pacific League of Associations for Rheumatology.
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2008-09-23
- Data Source
  KAKENHI-PROJECT-20591177

1. KITASATO Hidero (90195256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. 山本竜大 (40459805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. MAEKAWA Kohtaroh

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TSUKAMOTO Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAWAI Shinichi 川合 眞一

河合 眞一 カワイ シンイチ

Research Projects

Research Products

Co-Researchers

Pharmacogenetic study of methotrexate in patients with rheumatoid arthritis.Principal Investigator

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Adipokine network in systemic autoimmune diseasesPrincipal Investigator

Principal Investigator

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Clinical Significance of Adipocytokines in Rheumatoid ArthritisPrincipal Investigator

Principal Investigator

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An Experimental Study ofANovel Pro-ApoptoticAgent for RheumatoidArthritis and MalignancyPrincipal Investigator

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New therapeutic approach for rheumatoid arthritis by targeting the intracellular molecule.Principal Investigator

Principal Investigator

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Basic Studies of Novel Gene Therapy by Regulation of Transcription of the Inflammation-Related Gene.Principal Investigator

Principal Investigator

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[Book] Effects of adipokines on prostaglandin E2 production by rheumatoid synovial fibroblasts. In : Arachidonic Acid : Sources, Biosynthesis and Health Effects2014

Author(s)

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[Book] Arachidonic Acid: Sources, Biosynthesis and Health Effects.2014

Author(s)

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Data Source

[Book] Chapter 6: Effects of adipokines on prostaglandin E2 production by rheumatoid synovial fibroblasts. In: O’Keefe JM (Ed) Arachidonic Acid: Sources, Biosynthesis and Health Effects.2014

Author(s)

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[Book] Adiponectin enhances inflammation in rheumatoid synovial fibroblasts and chondrocytes. In : Adipokines2011

Author(s)

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[Book] Adiponectin enhances inflammation in rheumatoid synovial fibroblasts and chondrocytes. In: Preedy VR and Hunter RJ (Eds) Adipokines.2011

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[Book] ポケット版やさしいリウマチ治療薬の基礎知識2008

Author(s)

Total Pages

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Description

Data Source

[Book] ササッとわかる最新「関節リウマチ」治療法2008

Author(s)

Total Pages

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Data Source

[Book] ポケット版 やさしいリウマチ治療薬の基礎知識2008

Author(s)

Total Pages

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Data Source

[Book] やさしいリウマチ治療薬の基礎知識2006

Author(s)

Total Pages

KAWAI Shinichi 川合眞一

河合眞一カワイシンイチ

[Book] ポケット版やさしいリウマチ治療薬の基礎知識2008

[Journal Article] – A 3-Year Nationwide Comparative Observational Study in Japan (ACCEPT) –2014