IMAWARI Michio 井廻道夫

Researcher Number	70134228
External Links
Affiliation (based on the past Project Information) *help	2008: 昭和大学・医学部・教授, 医学部, 教授 2006 – 2008: 昭和大学, 医学部, 教授 2003 – 2004: Showa Univ., School of Medicine, Professor, 医学部, 教授 1993 – 2002: Jichi Medical School, Medicine, Professor, 医学部, 教授 1991 – 1992: University of Tokyo Faculty of Medicine Assistant professor, 医学部(病), 助教授 … More 1990: 東京大学, 医学部・附属病院, 講師 1989: 東京大学, 医学部(病), 講師 1988: 東京大学, 医学部, 講師 1987: ditto of Toky,Faculty of Medicine, 医学部(病), 助手 1986: 東大, 医学部(内科学), 助手 1986: 東大, 医学部, 助手 1985: 東京大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology / Radiation science
Keywords	Principal Investigator 細胞障害性T細胞 / C型肝炎 / C型肝炎ウイルス / hepatitis C virus / C型肝炎ウイルスコア抗原 / HLAB44 / ヘルパーT細胞 / HLA B44 / cytotoxic T cell / 抗原エピトープ … More / 肝癌 / helper T cell / エピトープ / Fas / TNF / インターフェロンγ / インターロイキン4 / hepatitis C / cytotoxic T lymphocyte / epitope / ELISpot / HLA-A24 / 抗原エピト-プ / チンパンジー / 遺伝子 / RFLP / アポA-【I】 / アポc-【III】 / アポB / 先天性リポ蛋白異常症 / cDNAクローニング / アポリポ蛋白 / 肝細胞増殖 / フィブロネクチン / フィブロネクチンフラグメント / 肝細胞増殖因子 / ラット肝細胞 / キラ-T細胞 / 腫瘍抗原 / 細胞傷害性T細胞 / hepatoma / killer T-cell / tumor-associated antigen / T細胞受容体 / 抗体 / Hepatitis C / Hepatitis C virus / Cytotoxic T cell / T cell receptor / Antibody / antigen epitope / パーフォリン / 変異 / パ-フォリン / perforin / DNAワクチン / GM-CSF / ワクチン / インターロイン12 / DNA vaccine / 免疫 / インターロイキン10 / HCV抗原 / C型肝炎ウイルスコア蛋白 / C型肝炎ウイルスNS3蛋白 / immunology / interferon-γ / interleukin-4 / interleukin-10 / インターフェロン / interferon … More Except Principal Investigator HCV / MRI / 内科 / 消化器内科 / 感染症 / ウイルス / B細胞トロピズム / リンパ増殖性疾患 / IRES依存性RNA翻訳 / C型肝炎ウイルス / B細胞感染 / 肝炎ウイルス / 免疫応答 / Immune response / 肝細胞癌 / 肝硬変症 / 再生結節 / 腫瘍栓 / ウッドチャック / MRI造形剤 / MRI(核磁気共鳴CT) / 肝硬変 / Hepatocellular carcinoma / Liver cirrhosis / Regeneration nodules / Tumor thrombus / Woodchuck Less

Analysis for mechanism of IRES dependent translation and pathogenesis of hepatitis C virus in B cells
- Principal Investigator
  
  ITO Takayoshi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Showa University
Research on cytotoxic T cell responses to hepatitis C virus infectionPrincipal Investigator
- Principal Investigator
  
  IMAWARI Michio
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Showa University
  Jichi Medical University
The Function of HCV specific TGF-β-producing helper T cell in chronic hepatitis C patient
- Principal Investigator
  
  NAKAMURA Ikuo
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  JICHI MEDICAL SCHOOL
Analysis of cellular immune responses in perihperal blood and liver tissues in HCV infectionPrincipal Investigator
- Principal Investigator
  
  IMAWARI Michio
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical School
Molecular and immunological study on the pathogenesis of hepatitis CPrincipal Investigator
- Principal Investigator
  
  IMAWARI Michio
- Project Period (FY)
  1995 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical School
Development of T-cell vaccine for hepatitis C virusPrincipal Investigator
- Principal Investigator
  
  IMAWARI Michio
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical School
チンパンジーにおけるC型肝炎ウイルス特異的細胞障害性T細胞応答の研究Principal Investigator
- Principal Investigator
  
  井廻道夫
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Jichi Medical University
C型肝炎ウイルスの特異的細胞障害性T細胞により認識される抗原エピトープの解析Principal Investigator
- Principal Investigator
  
  井廻道夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
Studies on the Immunopathogenesis of Viral Hepatitis CPrincipal Investigator
- Principal Investigator
  
  IMAWARI Michio
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical School
  The University of Tokyo
C型肝炎ウイルスの特異的細胞障害性T細胞により認識される抗原エピト-プの解析Principal Investigator
- Principal Investigator
  
  井廻道夫
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
Production of antibodies to inhibit the cytotoxic activities of hepatitis C virus-specific cytotoxic T cellsPrincipal Investigator
- Principal Investigator
  
  IMAWARI Michio
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Jichi Medical School
  The University of Tokyo
Molecular biological studies on a hepatoma-associated target antigen for a human killer T-cell clonePrincipal Investigator
- Principal Investigator
  
  IMAWARI Michio
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo
肝癌細胞株の分泌する肝細胞増殖因子の精製・純化Principal Investigator
- Principal Investigator
  
  井廻道夫
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
フィブロネクチンフラグメントの肝細胞増殖促進作用に関する研究Principal Investigator
- Principal Investigator
  
  井廻道夫
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
先天性リポ蛋白異常症におけるアポ蛋白構造遺伝子異常とその治療Principal Investigator
- Principal Investigator
  
  井廻道夫
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  The University of Tokyo
Diagnosis and evaluation of hepatocellular carcinoma and precancerous states using magnetic resonance imaging
- Principal Investigator
  
  ITAI Yuji
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  University of Toky,Faculty of Medicine.

All 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] Infection of B Cells with Hepatitis C Virus for the Development of Lymphoproliferative2009
- Author(s)
  Inokuchi M, Ito T, Uchikoshi M, Shimozuma Y, Morikawa K, Nozawa H,Shimazaki T,Hiroishi K, Miyakawa Y and Imawari M
- Journal Title
  
  Disorders in Patients with Chronic Hepatitis C. J Med Virol.81
  
  Pages: 619-627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590749
[Journal Article] Magnitude of CD8+ T-cell responses against hepatitis C virus and severity of hepatitis do not necessarily determine outcomes in acute hepatitis C virus infection.2009
- Author(s)
  Doi H, Hiroishi K, Shimazaki T, Eguchi J, Baba T, Ito T, Matsumura T, Nozawa H, Morikawa K, Ishii S, Hiraide A, Sakaki M, Imawari M.
- Journal Title
  
  Hepatology Research 39
  
  Pages: 256-265
- NAID
  10025324889
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590749
[Journal Article] Infection of B Cells with Hepatitis C Virus for the Development of Lymphoproliferative Disorders in Patients with Chronic Hepatitis C.2009
- Author(s)
  Inokuchi M, Ito T, Uchikoshi M, Shimozuma Y, Morikawa K, Nozawa H, Shimazaki T, Hiroishi K, Miyakawa Y, Imawari M.
- Journal Title
  
  Journal of Medical Virology 81
  
  Pages: 619-627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590749
[Journal Article] Magnitude of CD8+ T-cell responses against hepatitis C virus and severity of hepatitis do not necessarily determine outcomes in acute hepatitis C virus infection2009
- Author(s)
  Doi H, Hiroishi K, Shimazaki T, Eguchi J, Baba T, Ito T, Matsumura T, Nozawa H, Morikawa K, Ishii S, Hiraide A, Sakaki M, Imawari M
- Journal Title
  
  Hepatology Research 39
  
  Pages: 256-265
- NAID
  10025324889
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590749
[Journal Article] Evaluation of Serum B Cell Activating Factor (BAFF/BlyS) as an Immunological Marker for Lymphoproliferative Disorders Associated with Chronic Hepatitis C2009
- Author(s)
  Uchikoshi M, Ito T, Shimozuma Y, Inokuchi T, Morikawa K, Nozawa H, Shimazaki T and M. Imawari
- Journal Title
  
  The Showa University Journal of Medical Sciences (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590749
[Journal Article] Immune responses in hepatitis C virus infection and mechanisms of hepatitis C virus persistence2008
- Author(s)
  Hiroishi K, Ito T and Imawari M
- Journal Title
  
  Journal of Gastroenterol Hepatol 23
  
  Pages: 1473-1482
- Data Source
  KAKENHI-PROJECT-18590749
[Journal Article] Intrahepatic status of regulatory T cells in autoimmune liver disease and chronic viral hepatitis2008
- Author(s)
  Sakaki M, Hiroishi K, Baba T, Ito T, Hirayama Y, Saito K, Tonoike T, Kushima M and Imawari M
- Journal Title
  
  Hepatology Research 38
  
  Pages: 354-361
- NAID
  10024147832
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590749
[Journal Article] Intrahepatic status of regulatory T cells in autoimmune liver disease and chronic viral hepatitis.2008
- Author(s)
  Sakaki M, Hiroishi K, Baba T, Ito T, Hirayama Y, Saito K, Tonoike T, Kushima M, Imawari M.
- Journal Title
  
  Hepatology Research 38
  
  Pages: 354-361
- NAID
  10024147832
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590749
[Journal Article] Clonal Expansion of B cells is identified in Japanese Patients Infected with Hepatitis C virus2008
- Author(s)
  Inokuchi T, Ito T, Uchikoshi M, Shimozuma Y, Nozawa H, Shimazaki T and Imawari M
- Journal Title
  
  The Showa University Journal of Medical Sciences 23
  
  Pages: 29-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590749
[Journal Article] Immune responses in hepatitis C virus infection and mechanisms of hepatitis C virus persistence.2008
- Author(s)
  Hiroishi K, Ito T, Imawari M.
- Journal Title
  
  Journal of Gastroenterol Hepatology 23
  
  Pages: 1473-1482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590749
[Presentation] Infection of B Cells with Hepatitis C Virus for the Development of Lymphoproliferative Disorders in Patients with Chronic Hepatitis C.2008
- Author(s)
  Inokuchi M, Ito T, Uchikoshi M, Shimozuma Y, Morikawa K, Nozawa H, Shimazaki T, Hiroishi K, Imawari M.
- Organizer
  59th Annual Meeting of the American Association for the Study of Liver Disease
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-18590749
[Presentation] C型慢性肝炎患者におけるB細胞HCV感染とリンパ増殖性疾患発症についての検討2008
- Author(s)
  井口桃子, 伊藤敬義, 森川賢一, 打越学, 野沢妃佐子, 島崎とも江, 井廻道夫
- Organizer
  第94回日本消化器病学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-18590749
[Presentation] HCV関連リンパ増殖性疾患における血清B細胞増殖因子(BAFF/BLyS)2008
- Author(s)
  打越学, 伊藤敬義, 井口桃子, 森川賢一, 下間祐, 井廻道夫
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  松山
- Data Source
  KAKENHI-PROJECT-18590749
[Presentation] Infection of B Cells with Hepatitis C Virus for the Development of Lymphoproliferative Disorders in Patients with Chronic Hepatitis C2008
- Author(s)
  Inokuchi M, Ito T, Uchikoshi M, Shimozuma Y, Nozawa H, Shimazaki T, Hiroishi K, Miyakawa Y and Imawari M
- Organizer
  59th Annual Meeting of the American Association for the Study of Liver Disease
- Place of Presentation
  San Francisco
- Data Source
  KAKENHI-PROJECT-18590749
[Presentation] Evaluation of Serum B Cell Activating Factor (BAFF/BlyS)as an Immunological Marker for Lymphoproliferative Disorders Associated with Chronic Hepatitis C.2008
- Author(s)
  Uchikoshi M, Ito T, Shimozuma Y, Inokuchi T, Morikawa K, Nozawa H, Shimazaki T, M, Imawari.
- Organizer
  59th Annual Meeting of the American Association for the Study of Liver Diseas
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-18590749
[Presentation] Evaluation of Serum B Cell Activating Factor (BAFF/BlyS) as an Immunological Marker for Lympho proliferative Disorders Associated with Chronic Hepatitis C2008
- Author(s)
  Uchikoshi M, Ito T, Shimozuma Y, Inokuchi T, Morikawa K, Nozawa H, Shimazaki T and M. Imawari
- Organizer
  59th Annual Meeting of the American Association for the Study of Liver Disease
- Place of Presentation
  San Francisco
- Data Source
  KAKENHI-PROJECT-18590749
[Presentation] HCV関連リンパ増殖性疾患における血清B細胞増殖因子(BAFF/BLyS)2008
- Author(s)
  打越学, 伊藤敬義, 井口桃子, 森川賢一, 下間祐, 井廻道夫
- Organizer
  第94回日本消化器病学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-18590749
[Presentation] C型慢性肝炎患者におけるB細胞HCV感染とHCV関連リンパ増殖性疾患マーカーに対する抗ウイルス療法の効果2007
- Author(s)
  井口桃子、伊藤敬義、打越学、野沢妃佐子、島崎とも江、井廻道夫
- Organizer
  第43回日本肝臓学会総会、ワークショップ1「肝炎ウイルス研究の進歩」
- Place of Presentation
  ホテルグランパシフィックメリディアン
- Data Source
  KAKENHI-PROJECT-18590749
[Presentation] C型慢性肝炎患者におけるB細胞HCV感染と免疫グロブリン超可変領域遺伝子clonality発症の解析2007
- Author(s)
  井口桃子、伊藤敬義、打越学、森川賢一、野沢妃佐子、島崎とも江、井廻道夫
- Organizer
  第47回京都肝セルバイオロジー研究会
- Place of Presentation
  ホテルオークラ京都
- Year and Date
  2007-07-14
- Data Source
  KAKENHI-PROJECT-18590749
[Presentation] C型慢性肝炎患者におけるリンパ球系細胞へのHCV感染及びその病態に及ぼす影響とIFN療法への反応性2006
- Author(s)
  伊藤敬義, 井口桃子, 打越学, 野沢妃佐子, 島崎とも江, 井廻道夫
- Organizer
  第42回日本肝臓学会総会、シンポジウム1「難治性ウイルス肝炎に対する新しい治療の基礎的臨床的検討」
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18590749
[Presentation] C型肝炎ウィルス感染者におけるB細胞へのHCV感染とHCV関連clonalityの検討2006
- Author(s)
  井口桃子, 伊藤敬義, 打越学, 野沢妃佐子, 島崎とも江, 井廻道夫
- Organizer
  第42回日本肝臓学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18590749

1. MORIYAMA Takashi (10240706)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
2. KANEKO Takashi (10254913)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. NAKAMURA Ikuo (40251243)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. ITO Takayoshi (50317517)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
5. 安藤量基 (20265276)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. HIROISHI Kazumasa (80296996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ITAI Yuji (30010268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YOSHIKAWA Kohki (40114714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. WATANABE Tokuko (40092382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHIGA Junji (10110694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. IIO Masahiro (80143486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大西真 (00183236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. GUNJI Toshiaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAKAGAMA Hitoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 中釜斉

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

IMAWARI Michio 井廻 道夫

Research Projects

Research Products

Co-Researchers

Analysis for mechanism of IRES dependent translation and pathogenesis of hepatitis C virus in B cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on cytotoxic T cell responses to hepatitis C virus infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Function of HCV specific TGF-β-producing helper T cell in chronic hepatitis C patient

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of cellular immune responses in perihperal blood and liver tissues in HCV infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular and immunological study on the pathogenesis of hepatitis CPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of T-cell vaccine for hepatitis C virusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

チンパンジーにおけるC型肝炎ウイルス特異的細胞障害性T細胞応答の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

C型肝炎ウイルスの特異的細胞障害性T細胞により認識される抗原エピトープの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Studies on the Immunopathogenesis of Viral Hepatitis CPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

C型肝炎ウイルスの特異的細胞障害性T細胞により認識される抗原エピト-プの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Production of antibodies to inhibit the cytotoxic activities of hepatitis C virus-specific cytotoxic T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular biological studies on a hepatoma-associated target antigen for a human killer T-cell clonePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肝癌細胞株の分泌する肝細胞増殖因子の精製・純化Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

フィブロネクチンフラグメントの肝細胞増殖促進作用に関する研究Principal Investigator

IMAWARI Michio 井廻道夫