YABE Chihiro 矢部千尋

… Alternative Names

NISHIMURA Chihiro 西村千尋

西村千尋

矢部千尋(西村千尋) ヤベチヒロ

西村千尋

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Researcher Number	70150571
Other IDs
Affiliation (based on the past Project Information) *help	2015: 京都府立医科大学, 大学院医学研究科, 教授 2011 – 2015: 京都府立医科大学, 医学(系)研究科(研究院), 教授 2012: 京都府立医科大学, 医学研究科, 教授 2012: 京都府立医科大学, 大学院・医学研究科, 教授 2008 – 2010: Kyoto Prefectural University of Medicine, 医学研究科, 教授 … More 2003 – 2006: 京都府立医科大学, 医学研究科, 教授 1999 – 2002: 京都府立医科大学, 医学部, 教授 1995: National Children's Medical Research Center,Department of Pediatric Pharmacology, laborrtory Chief, 小児医療研究センター・小児薬理研究部, 室長 1994: 国立小児病院, 小児医療研究センター・小児薬理研究部・中毒副作用研究室, 室長 1993: 国立小児病院, 小児医療研究センター・小児薬理研究部, 室長 1988: 国立小児病院, 小児医療研究センター・小児茉理研究部・中毒, 研究員 Less
Review Section/Research Field	Principal Investigator General pharmacology / Applied pharmacology / General pharmacology / 応用薬理学・医療系薬学 / Neurochemistry/Neuropharmacology Except Principal Investigator General pharmacology / Urology / Urology / General physiology
Keywords	Principal Investigator 循環器・高血圧 / aldose reductase / 糖尿病 / アルドース還元酵素 / 循環器 / 活性酸素種 / Cardiovascular system / Reactive oxygen species / Genetically modified mice / 酵素 … More / 遺伝子 / 活性酸素 / 遺伝子組み換えマウス / transgenic mouse / ischemia-reperfusion injury / heart / 虚血・再灌流障害 / 遺伝子改変マウス / 虚血・再還流障害 / 心臓 / diabetic complications / gene targeting / 酵素欠失マウス / 糖尿病合併症 / ジーンターゲティング / 肝臓 / 高血圧症 / 酸化ストレス / 腎臓 / 細胞老化 / 慢性腎臓病 / NADPH オキシダーゼ / メタボリックシンドローム / チャネル / 不整脈 / 薬理学 / シグナル伝達 / MAP kinase / H_2O_2 / cDNA macroarray / 高血糖 / 酸化的ストレス / イムノアッセイ / mRNA / 発現調節 / 培養神経系細胞 … More Except Principal Investigator IGFBP-3 / IGF-I / IGF-1 / 線維化 / NADPHオキシダーゼ / 活性酸素 / erectile dysfunction / diabetes mellitus / penis / 陰茎海綿体平滑筋 / ラット / 糖尿病 / 勃起障害 / Erectile Dysfunction (ED) / IGFBP-1 / 勃起障害(ED) / ジギタリス中毒 / カルシウム過負荷 / 心筋障害 / イオンチャネル / 細胞内小胞 / 脳浮腫 / スクロース / 尿素 / アルドース還元酵素 / グリア細胞 / 浸透圧 / 細胞容積 Less

A study on signaling pathways associated with NOX4/NADPH oxidase for the development of new antifibrotic drugs
- Principal Investigator
  
  Katsuyama Masato
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto Prefectural University of Medicine
Development of a new NOX1-targeted strategy for the treatment of metabolic syndromePrincipal Investigator
- Principal Investigator
  
  Yabe Chihiro
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto Prefectural University of Medicine
A study on the role of NOX1/NADPH oxidase in cardiac arrhythmiaPrincipal Investigator
- Principal Investigator
  
  YABE Chihiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto Prefectural University of Medicine
Study on roles of a novel NADPH oxidase isoform in the development of lifestyle related diseasesPrincipal Investigator
- Principal Investigator
  
  YABE Chihiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto Prefectural University of Medicine
Vascular remodeling in Nox1/NADPH oxidase deficient micePrincipal Investigator
- Principal Investigator
  
  YABE Chihiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto Prefectural University of Medicine
脳浮腫発症に果たすアルドース還元酵素の役割解明と酵素阻害剤による治療の試み
- Principal Investigator
  
  丸中良典
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Kyoto Prefectural University of Medicine
Paradoxical roles of the aldehyde-metabolizing enzyme, aldose reductase in cardioprotectionPrincipal Investigator
- Principal Investigator
  
  YABE Chihiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyoto Prefectural University of Medicine
Clarification of the sexual dysfunction by diabetes
- Principal Investigator
  
  SHO Jintetsu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kyoto Prefectural University of Medicine
Effects of insulin - like growth factor binding protein-3 (IGFBP-3) on diabetes - induced erectile dysfunction (ED)
- Principal Investigator
  
  SOU Jintetsu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kyoto Prefectural University of Medicine
酸化的ストレスによる糖尿病合併症発症因子の発現誘導と病態モデルでの解析Principal Investigator
- Principal Investigator
  
  矢部千尋 (西村千尋)
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyoto Prefectural University of Medicine
Generation of aldose reductase knockout mouse by gene targeting and expression of human enzymePrincipal Investigator
- Principal Investigator
  
  NISHIMURA Chihiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  National Children's Medical Research Center
培養神経系細胞を用いたアルドース還元酵素発現調節因子の解析Principal Investigator
- Principal Investigator
  
  西村千尋
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  National Research Institute for Child Health and Development
カルシウム過負荷による心筋細胞機能不全の機序
- Principal Investigator
  
  明楽泰
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  National Research Institute for Child Health and Development

All 2015 2011 2009 2008 2005 2004

All Journal Article Presentation Patent

[Journal Article] NADPH oxidase isoforms and anti-hypertensive effects of atorvastatin demonstrated in two animal models.2009
- Author(s)
  Cui W, Matsuno K, Iwata K, Ibi M, Katsuyama M, Kakehi T, Sasaki M, Ikami K, Zhu K, Yabe-Nishimura C.
- Journal Title
  
  J Pharmacol Sci 111
  
  Pages: 260-268
- NAID
  10026154161
- Data Source
  KAKENHI-PROJECT-20390071
[Journal Article] NOX enzymes and diabetic complications.2008
- Author(s)
  Kakehi T, Yabe-Nishimura C.
- Journal Title
  
  Semin Immunopathol 30
  
  Pages: 301-314
- Data Source
  KAKENHI-PROJECT-20390071
[Journal Article] The AP-1 site is essential for the promoter activity of NOX1/NADPH oxidase, a vascular superoxide-producing enzyme : Possible involvement of the ERK1/2-JunB pathway.2008
- Author(s)
  Cevik MO, Katsuyama M, Kanda S, Kaneko T, Iwata K, Ibi M, Matsuno K, Kakehi T, Cui W, Sasaki M, Yabe-Nishimura C.
- Journal Title
  
  Biochem Biophys Res Commun 374
  
  Pages: 351-355
- Data Source
  KAKENHI-PROJECT-20390071
[Journal Article] Aldose reductase exacerbates ischemia-reperfusion injury in isolated mouse hearts2004
- Author(s)
  Iwata K, Matsuno K, Yabe-Nishimura C
- Journal Title
  
  J Pharmacol Sci 94 Suppl I
  
  Pages: 95-95
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590470
[Journal Article] Characterization of htAKR, a novel gene product in the aldo-keto reductase family specifically expressed in human testis.2004
- Author(s)
  Azuma Y., Soh J., Katsuyama M., Yabe C., et al.
- Journal Title
  
  Molecular Human Reproduction 2
  
  Pages: 209-212
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591706
[Patent] 虚血または虚血再灌流によって起こる臓器障害若しくは組織障害の予防又は治療剤2005
- Inventor(s)
  岩田和実, 矢部千尋, 日比千尋
- Industrial Property Rights Holder
  矢部千尋, (株)三和化学研究所
- Industrial Property Number
  2005-044889
- Filing Date
  2005-02-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590470
[Presentation] NOX4/NADPHオキシダーゼ由来活性酸素種の標的蛋白の探索2015
- Author(s)
  勝山真人、荒川憲昭、矢部千尋
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PROJECT-25460339
[Presentation] ほ乳類におけるNOX/NADPH oxidaseの生理機能2015
- Author(s)
  勝山真人、矢部千尋
- Organizer
  BMB2015（第38回日本分子生物学会年会・第88回日本生化学会大会合同大会）
- Place of Presentation
  神戸
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-25460339
[Presentation] Renal redox-sensitive signaling in type 1 diabetes is suppressed in Nox1-deficient mice.2011
- Author(s)
  Zhu K, Matsumoto M, Iwata K, Yabe-Nishimura C.
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-03-17
- Data Source
  KAKENHI-PROJECT-20390071
[Presentation] Renal redox-sensitive signaling in type 1 diabetes is suppressed in Nox 1-deficient mice2011
- Author(s)
  Zhu Kai, Matsumoto M, Iwata K, Yabe-Nishimura C
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-03-17
- Data Source
  KAKENHI-PROJECT-20390071
[Presentation] 糖尿病性腎症モデルにおける活性酸素産生酵素NOX1の発現と酸化的ストレス2009
- Author(s)
  筧朋子、岩田和実、Taye Ashraf、松野邦晴、矢部千尋
- Organizer
  第52回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20390071
[Presentation] 活性酸素産生酵素NADPHオキシダーゼの関わる疾患と病態2009
- Author(s)
  矢部千尋、松野邦晴、衣斐督和、岩田和実
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-03-16
- Data Source
  KAKENHI-PROJECT-20390071
[Presentation] 腎臓における活性酸素産生酵素Nox1の発現と腎症モデルを用いた解析2008
- Author(s)
  筧朋子、岩田和実、Taye Ashraf、松野邦晴、矢部千尋
- Organizer
  第23回日本糖尿病合併症学会
- Place of Presentation
  東京
- Year and Date
  2008-10-03
- Data Source
  KAKENHI-PROJECT-20390071
[Presentation] 糖尿病性腎症モデルにおける活性酸素産生酵素Nox1の解析2008
- Author(s)
  筧朋子、岩田和実、Taye Ashraf、松野邦晴、矢部千尋
- Organizer
  第52回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Year and Date
  2008-05-22
- Data Source
  KAKENHI-PROJECT-20390071
[Presentation] 腎臓における活性酸素産生酵素Nox1/NADPH oxidaseの発現の解析2008
- Author(s)
  筧朋子、松野邦晴、岩田和実、Taye Ashraf、矢部千尋
- Organizer
  第114回日本薬理学会近畿部会
- Place of Presentation
  神戸
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-20390071

1. IWATA Kazumi (60305571)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
2. KATSUYAMA Masato (60315934)

# of Collaborated Projects: 5 results

# of Collaborated Products: 5 results
3. MSATSUMOTO Misaki (80533926)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SOU Jintetsu (40305587)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. CHOU Ka (50599222)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. OKIGAKI Mitsuhiko (10333197)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KAWAUCHI Akihiro (90240952)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. MIKI Tsuneharu (10243239)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 松野邦晴 (50420708)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
10. HIRAYAMA Aki (20323298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. KAKEHI Tomoko (20433279)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
12. KOKAI Yasuo (20178239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NAKAMURA Naoto (40227921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MIZUTANI Yoichi (10243031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ARAKAWA Noriaki (60398394)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 西中徹 (90295642)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 丸中良典 (00127036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 峯浦一喜 (70134103)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 西村恒彦 (70237733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 新里直美 (00237645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 宮崎裕明 (30360027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 明楽泰 (10192923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 福島義博 (40114780)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YABE Chihiro 矢部 千尋

NISHIMURA Chihiro 西村 千尋

西村千尋

矢部 千尋(西村千尋) ヤベ チヒロ

西村 千尋

Research Projects

Research Products

Co-Researchers

A study on signaling pathways associated with NOX4/NADPH oxidase for the development of new antifibrotic drugs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a new NOX1-targeted strategy for the treatment of metabolic syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study on the role of NOX1/NADPH oxidase in cardiac arrhythmiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on roles of a novel NADPH oxidase isoform in the development of lifestyle related diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Vascular remodeling in Nox1/NADPH oxidase deficient micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脳浮腫発症に果たすアルドース還元酵素の役割解明と酵素阻害剤による治療の試み

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Paradoxical roles of the aldehyde-metabolizing enzyme, aldose reductase in cardioprotectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of the sexual dysfunction by diabetes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of insulin - like growth factor binding protein-3 (IGFBP-3) on diabetes - induced erectile dysfunction (ED)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

酸化的ストレスによる糖尿病合併症発症因子の発現誘導と病態モデルでの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Generation of aldose reductase knockout mouse by gene targeting and expression of human enzymePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

培養神経系細胞を用いたアルドース還元酵素発現調節因子の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

YABE Chihiro 矢部千尋

NISHIMURA Chihiro 西村千尋

矢部千尋(西村千尋) ヤベチヒロ

西村千尋