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TAKIKAWA Osamu  滝川 修

ORCIDConnect your ORCID iD *help
Researcher Number 70163342
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2017: 国立研究開発法人国立長寿医療研究センター, その他部局等, その他(移行)
2015 – 2016: 国立研究開発法人国立長寿医療研究センター, ラジオアイソトープ管理室, 客員研究員
2014: 国立長寿医療研究センター, 治療薬探索研究部, 室長
2012 – 2014: 独立行政法人国立長寿医療研究センター, 治療薬探索研究部, 室長
2012 – 2013: 独立行政法人国立長寿医療研究センター, 治療薬探索研究部, 研究室長 … More
2009 – 2011: National Institute for Longevity Sciences,NCGG, ラジオアイソトープ管理室, 室長
2004 – 2005: 国立長寿医療センター, 研究所・ラジオアイソトープ管理室, 室長
2002 – 2003: 北海道大学, 大学院・医学研究科, 助教授
1997: 大阪バイオ研, 研究員
1992 – 1996: (財)大阪バイオサイエンス研究所, 第4研究部, 研究員
1995: Osaka Bioscience Institute, Department of Cell Biology, Research Scientist, 第4研究部・研究所, 研究員
1993 – 1994: 財団法人大阪バイオサイエンス研究所, 第4研究部, 研究員
1993: 〃, 第4研究部, 研究員
1989 – 1990: (財)大阪バイオサイエンス研究所, 第4研究部, 研究員 Less
Review Section/Research Field
Principal Investigator
Pathological medical chemistry / General medical chemistry / 代謝生物化学 / Functional biochemistry
Except Principal Investigator
Chemical biology / 物質生物化学 / Structural biochemistry / General medical chemistry / General pharmacology
Keywords
Principal Investigator
トリプトファン代謝 / アルツハイマー病 / IFN-γ / インドールアミン酸素添加酵素 / 分子生物学 / 誘導酵素 / ノックアウトマウス / アミロイドβペプチド / 転写制御因子 / 細胞内情報伝達機構 … More / IRF-1 / tryptophan metabolism / 抗細胞内寄生虫活性 / トリプトファン / ミクログリア / キノリン酸 / 神経毒 / IDO / IDO / 酸素添加酵素 / サイトカイン / インターフェロン-γ / インターフェロンーγ / 細胞内情報伝達 / Oxygenase / Interferon-gamma / Trans-acting factor / Signal transduction / Cytokine / Tryptophan metabolism / 酵素誘導 / STAT1 / STAT 1 / interferon-gamma / indoleamine 2,3-dioxygenase / transcriptional factor / cytokine / ISRE / キヌレニン化 / インターフェロンガンマ / 興奮性神経毒 / 翻訳語蛋白修飾 / 感染防御機構 / 翻訳後蛋白修飾 / Kynurenylation / Alzheimer's disease / knockout mouse / INF-γ / excitatory neurotoxin / post-translational modification / quinolinic acid / 認知症 / エクソソーム / リキッドバイオプシー / 多層的オミックス解析 / 神経細胞由来エクソソーム / アストロサイト由来エクソソーム / 脳リキッドバイオプシー / オミックス解析 / 軽度認知症障害 / 代謝異常学 / 疾患エクソソーム … More
Except Principal Investigator
移植 / 拒絶反応 / 単球 / マクロファージ / self / nonself / GST pull-down / イメージング質量分析 / アルツハイマー病 / タウ / 創薬スクリーニング / 薬物動態 / PET化合物 / 神経変性疾患 / ロボットシステム / 認知症 / 診断薬 / タウオパシー / PET / 治療薬 / エフェクタ-細胞 / 宿主細胞 / マクロファ-ジ / 移植@腫瘍免疫 / 細胞傷害活性 / effector細胞 / Transplantation / Allograft Rejection / Effector Cells / Host Cells / Monocyte / Macrophage / 自己・非自己 / 認識 / 主要組織適合性抗原 / モノクローナル抗体 / コンジェニックマウス / 拒絶 / 自己-非自己 / transplantation / recognition / major histocompatibility complex / macrophage / monoclonal antibody / congenic mice / rejection / 自己 / 非自己 / 細胞障害性T細胞 / NK細胞 / 組織適合性抗原 / 皮フ移植 / 細胞傷害性T細胞 / cytotoxic T cells / NK cells / macrophages / Histocompatibility antigen / Skin allograft / エンドセリン受容体 / 血管平滑筋 / カルシウムチャネル / アフリカツメガエル卵母細胞 / カルシウム取り込み / 酵母two-hybrid / _CDNAクローニング / cDNAクローニング / エンドセリン / 収縮 / 受容体作動性カルシウムチャネル / Endothelin receptor / Vascular smooth muscle cell / Ca^<2+> channel / Xenopus oocyte / Ca^<2+> uptake / yeast two-hybrid / cDNA cloning Less
  • Research Projects

    (12 results)
  • Research Products

    (127 results)
  • Co-Researchers

    (31 People)
  •  Pathological analysis of Alzheimer`s disease through multi-layered omics study of blood exosomes derived from brainPrincipal Investigator

    • Principal Investigator
      TAKIKAWA Osamu
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      National Center for Geriatrics and Gerontology
  •  Novel Affinity Screening System of PET Probe for Tau aggregates using Human Brain Tissue Microsection

    • Principal Investigator
      YOSHIMI Tatsuya
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical biology
    • Research Institution
      National Center for Geriatrics and Gerontology
  •  The mechanisms of quinolinic acid-induced infiltration of reactive astrocytes and the amyloid beta peptide production in the activated glial cellsPrincipal Investigator

    • Principal Investigator
      TAKIKAWA Osamu
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      National Center for Geriatrics and Gerontology
  •  Molecular mechanisms of the aberrant metabolism of tryptophan in Alzheimer's diseasePrincipal Investigator

    • Principal Investigator
      TAKIKAWA Osamu
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      National Center for Geriatrics and Gerontology
  •  Structure and function of receptor-operated Ca^<2+> channels and development of specific blockers of the channels

    • Principal Investigator
      MIWA Soichi
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Generation of indoleamine 2,3-dioxygenase-dificient mousePrincipal Investigator

    • Principal Investigator
      TAKIKAWA Osamu
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  IFN−γで誘導されるトリプトファン分解酵素のノックアウトマウスの作製Principal Investigator

    • Principal Investigator
      滝川 修
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Osaka Bioscience Institute
  •  Mechanism of allograft rejection : moleclar biological analysis of self/nonself recognition

    • Principal Investigator
      YOSHIDA Ryotaro
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Osaka Bioscience Institute
  •  Molecular cloning of cDNAs for transcriptional factors of indoleamine 2,3-dioxygenase induced by IFN-gammaPrincipal Investigator

    • Principal Investigator
      TAKIKAWA Osamu
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      Osaka Bioscience Institute
  •  Mechanism of allograft rejection : molecular biological analysis of self/nonself recognition

    • Principal Investigator
      YOSHIDA Ryotaro
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      Osaka Bioscience Institute
  •  Molecular cloning of trans-acting factor cDNA for IFN-gamma-inducible indoleamine 2,3-dioxygenasePrincipal Investigator

    • Principal Investigator
      TAKIKAWA Osamu
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      代謝生物化学
    • Research Institution
      Osaka Bioscience Institute
  •  Novel Lymphoid Cells Possessing. Both T and B Lymphocyte Antigenslts Characteristics and Function

    • Principal Investigator
      YOSHIDA Ryotaro
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      物質生物化学
    • Research Institution
      Osaka Bioscience Institute

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Patent

  • [Journal Article] Metabolome analysis reveals the association between the kynurenine pathway and human herpesvirus 6 encephalopathy in immunocompetent children.2017

    • Author(s)
      Torii, Y. Kawano, Y. Sato, H. Fujimori, T. Sasaki, K. Kawada, J. Takikawa, O. Lim, C. K. Guillemin, G. J. Ohashi, Y. Ito, Y.
    • Journal Title

      Metabolomics

      Volume: 13 Pages: 126-126

    • DOI

      10.1007/s11306-017-1268-x

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10107, KAKENHI-PROJECT-15J40217, KAKENHI-PROJECT-15K08326, KAKENHI-PROJECT-16K19638
  • [Journal Article] 網羅的血液miRNA解析による軽度認知障害のバイオマーカー探索2017

    • Author(s)
      茅野光範、桧垣小百合、佐藤準一、新飯田俊平、松本健治、松原悦郎、滝川 修
    • Journal Title

      日本認知症学会誌

      Volume: 31 Pages: 79-85

    • Data Source
      KAKENHI-PROJECT-15K08326
  • [Journal Article] 脳リキッドバイオプシー2017

    • Author(s)
      滝川 修
    • Journal Title

      MEDCHEM NEWS

      Volume: 27 Pages: 64-69

    • Data Source
      KAKENHI-PROJECT-15K08326
  • [Journal Article] Indoleamine-2, 3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B.2016

    • Author(s)
      Yoshio S, Sugiyama M, Shoji H, Mano Y, Mita E, Okamoto T, Matsuura Y, Okuno A, Takikawa O, Mizokami M, Kanto T.
    • Journal Title

      Hepatology

      Volume: 63 Pages: 83-94

    • DOI

      10.1002/hep.28282

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08326, KAKENHI-PROJECT-25860574
  • [Journal Article] Plasma microRNA biomarker detection for mild cognitive impairment using differential correlation analysis2016

    • Author(s)
      Kayano M, Higaki S, Satoh JI, Matsumoto K, Matsubara E, Takikawa O, Niida S.
    • Journal Title

      Biomark Res.

      Volume: 4 Pages: 22-33

    • DOI

      10.1186/s40364-016-0076-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05228, KAKENHI-PROJECT-16K15483, KAKENHI-PROJECT-15K08326
  • [Journal Article] New Inhibitors of Indoleamine 2,3-Dioxygenase 1: Molecular Modeling Studies, Synthesis, and Biological Evaluation.2016

    • Author(s)
      Coluccia A, Passacantilli S, Famiglini V, Sabatino M, Patsilinakos A, Ragno R, Mazzoccoli C, Sisinni L, Okuno A, Takikawa O, Silvestri R, La Regina G.
    • Journal Title

      J Med Chem.

      Volume: 59 Pages: 9760-9773

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08326
  • [Journal Article] The hepatocyte growth factor antagonist NK4 inhibits indoleamine-2,3-dioxygenase expression via the c-Met-phosphatidylinositol 3-kinase-AKT signaling pathway.2016

    • Author(s)
      Wang D, Saga Y, Sato N, Nakamura T, Takikawa O, Mizukami H, Matsubara S, Fujiwara H
    • Journal Title

      Int J Oncol.

      Volume: 48 Pages: 2303-2309

    • DOI

      10.3892/ijo.2016.3486

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25462606, KAKENHI-PROJECT-15K08326
  • [Journal Article] Affinity imaging mass spectrometry (AIMS): high-throughput screening for specific small molecule interactions with frozen tissue sections.2015

    • Author(s)
      Yoshimi T, Kawabata S, Taira S, Okuno A, Mikawa R, Murayama S, Tanaka K, Takikawa O.
    • Journal Title

      Analyst

      Volume: 140 Pages: 7202-7208

    • DOI

      10.1039/c5an01381j

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08326
  • [Journal Article] Indoleamine 2,3-dioxygenase promotes peritoneal metastasis of ovarian cancer via inducing immunosuppressive environment2014

    • Author(s)
      Tanizaki Y(1), Kobayashi A, Toujima S, Shiro M, Mizoguchi M, Mabuchi Y, Yagi S, Minami S, Takikawa O, Ino K.
    • Journal Title

      Cancer Science

      Volume: 105 Pages: 966-73

    • DOI

      10.1111/cas.12445

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23592347, KAKENHI-PROJECT-23592459, KAKENHI-PROJECT-24590397, KAKENHI-PROJECT-26462535, KAKENHI-PROJECT-26861338
  • [Journal Article] トリプトファン代謝異常の病態生理学的意義:がんとアルツハイマー病を中心として2014

    • Author(s)
      滝川 修
    • Journal Title

      アミノ酸研究

      Volume: 8 Pages: 25-34

    • Data Source
      KAKENHI-PROJECT-24590397
  • [Journal Article] Association of enhanced activity of indoleamine 2,3-dioxygenase in dendritic cells with the induction of regulatory T cells in chronic hepatitis C infection.2013

    • Author(s)
      Higashitani K, Kanto T, Kuroda S, Yoshio S, Matsubara T, Kakita N, Oze T, Miyazaki M, Sakakibara M, Hiramatsu N, Mita E, Imai Y, Kasahara A, Okuno A, Takikawa O, Hayashi N, Takehara T.
    • Journal Title

      J Gastroenterol.[Epub ahead of print]

      Volume: 未定

    • NAID

      10031177017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Journal Article] Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer's disease2013

    • Author(s)
      Tajima Y, Ishikawa M, Maekawa K, Murayama M, Senoo Y, Nishimaki-Mogami T, Nakanishi H, Ikeda K, Arita M, Taguchi R, Okuno A, Mikawa R, Niida S, Takikawa O, Saito Y.
    • Journal Title

      Lipids Health Dis.

      Volume: 12 Pages: 68-68

    • DOI

      10.1186/1476-511x-12-68

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22116001, KAKENHI-PLANNED-22116006, KAKENHI-PROJECT-24390067, KAKENHI-PROJECT-24590397, KAKENHI-PROJECT-24619007, KAKENHI-PUBLICLY-25116702, KAKENHI-PROJECT-25750068
  • [Journal Article] NMR-based metabolomics of urine in a mouse model of Alzheimer’s disease: identification of oxidative stress biomarkers2013

    • Author(s)
      Fukuhara, K., Ohno, A., Ota, Y., Senoo, Y., Maekawa, K., Okuda, H., Kurihara, M., Okuno, A., Niida, S., Saito, Y., Takikawa, O
    • Journal Title

      J. Clin. Biochem. Nutr.

      Volume: 52 Issue: 2 Pages: 133-138

    • DOI

      10.3164/jcbn.12-118

    • NAID

      130004466706

    • ISSN
      0912-0009, 1880-5086
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790126, KAKENHI-PROJECT-24590397
  • [Journal Article] Synthesis and biological evaluation of novel tryptoline derivatives as indoleamine 2,3-dioxygenase (IDO) inhibitors2013

    • Author(s)
      Tanaka, Minoru; Li, Xin; Hikawa, Hidemasa; Suzuki, Takafumi; Tsutsumi, Katsuhiko; Sato, Masashi; Takikawa, Osamu; Suzuki, Hideharu; Yokoyama, Yuusaku,
    • Journal Title

      Bioorg Med Chem.

      Volume: 21(5) Pages: 1159-1165

    • DOI

      10.1016/j.bmc.2012.12.028

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590147, KAKENHI-PROJECT-24590397
  • [Journal Article] Downregulation of indoleamine-2,3-dioxygenase in cervical cancer cells suppresses tumor growth by promoting natural killer cell accumulation.2012

    • Author(s)
      Sato, N.
    • Journal Title

      Oncol Rep

      Volume: 28 Pages: 1574-1578

    • DOI

      10.3892/or.2012.1984

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659493, KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-24590397
  • [Journal Article] Indoleamine-2, 3-dioxygenase, an immunosuppressive enzyme that inhibits natural killer cell function, as a useful target for ovarian cancer therapy2012

    • Author(s)
      Wang, D.
    • Journal Title

      Int J Oncol.

      Volume: 40 Pages: 929-34

    • DOI

      10.3892/ijo.2011.1295

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390296, KAKENHI-PROJECT-21590353, KAKENHI-PROJECT-23659493
  • [Journal Article] Novel candesartan derivatives as indoleamine 2,3-dioxygenase inhibitors2012

    • Author(s)
      Matsuno K, Yamazaki H, Isaka Y, takai K, Unno Y, Ogo N, Ishikawa Y, Fujii S, Takikawa O, Asai A
    • Journal Title

      Med.Chem.Commun.

      Volume: 3 Pages: 475-479

    • DOI

      10.1039/c2md00278g

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590353, KAKENHI-PROJECT-22590039, KAKENHI-PROJECT-24590141
  • [Journal Article] Identification on novel kynurenine production-inhibiting benzenesulfonamide derivatives in cancer cells2012

    • Author(s)
      Nakano S, Takai K, Isaka Y, Takahashi S, Unno Y, Ogo N, Matsuno K, Takikawa O, Asai A.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 419 Pages: 556-561

    • DOI

      10.1016/j.bbrc.2012.02.059

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590353, KAKENHI-PROJECT-24501362
  • [Journal Article] Interferon-γ regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2,3 dioxygenase(IDO).2011

    • Author(s)
      Croitoru-Lamoury J, Lamoury FM, Caristo M, Suzuki K, Walker D, Takikawa O, Taylor R, Brew BJ.
    • Journal Title

      PLoS One.

      Volume: 6 Pages: 14698-14698

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Journal Article] Vascular endothelial expression of indoleamine 2,3-dioxygenase 1 forms a positive gradient towards the feto-maternal interface2011

    • Author(s)
      Blaschitz A, Gauster M, Fuchs D, Lang I, Maschke P, Ulrich D, Karpf E, Takikawa O, Schimek MG, Dohr G, Sedlmayr P
    • Journal Title

      PLoS ONE

      Volume: 6

    • DOI

      10.1371/journal.pone.0021774

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Journal Article] Interferon-γregulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2, 3 dioxygenase(IDO)2011

    • Author(s)
      Croitoru-Lamoury J, Lamoury FM, Caristo M, Suzuki K, Walker D, Takikawa O, Taylor R, Brew BJ
    • Journal Title

      PLoS One

      Volume: 16 ; 6(2)

    • DOI

      10.1371/journal.pone.0014698

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Journal Article] Indoleamine 2,3-dioxygenase promotes peritoneal dissemination of ovarian cancer through inhibition of natural killer cell function and angiogenesis promotion.2011

    • Author(s)
      Nonaka H, Saga Y, Fujiwara H, Akimoto H, Yamada A, Kagawa S, Takei Y, Machida S, Takikawa O, Suzuki M.
    • Journal Title

      Int J Oncol.

      Volume: 38 Pages: 113-120

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Journal Article] Indoleamine 2, 3-dioxygenase promotes peritoneal dissemination of ovarian cancer through inhibition of natural killercell function and angiogenesis promotion2011

    • Author(s)
      Nonaka H, Saga Y, Fujiwara H, Akimoto H, Yamada A, Kagawa S, Takei Y, Machida S, Takikawa O, Suzuki M.
    • Journal Title

      Int J Oncol

      Volume: 38 Pages: 113-120

    • DOI

      10.3892/ijo_00000830

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Journal Article] Indoleamine 2,3-dioxygenase expression predicts impaired survival of invasive cervical cancer patients treated with radical hysterectomy.2010

    • Author(s)
      Inaba T, Ino K, Kajiyama H, Shibata K, Yamamoto E, Kondo S, Umezu T, Nawa A, Takikawa O, Kikkawa F.
    • Journal Title

      Gynecol Oncol

      Volume: 117 Pages: 423-428

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Journal Article] Indoleamine 2, 3-dioxygenase expression predicts impaired survival of invasive cervical cancer patients treated with radical hysterectomy2010

    • Author(s)
      Inaba T, Ino K, Kajiyama H, Shibata K, Yamamoto E, Kondo S, Umezu T, Nawa A, Takikawa O, Kikkawa F
    • Journal Title

      Gynecol Oncol

      Volume: 117 Pages: 423-428

    • DOI

      10.1016/j.ygyno.2010.02.028

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Journal Article] S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2, 3-dioxygenase2010

    • Author(s)
      Matsuno K, Takai K, Isaka Y, Unno Y, Sato M, Takikawa O, Asai A
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 20 Pages: 5126-5129

    • DOI

      10.1016/j.bmcl.2010.07.025

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Journal Article] S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase.2010

    • Author(s)
      Matsuno K, Takai K, Isaka Y, Unno Y, Sato M, Takikawa O, Asai A.
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 20 Pages: 5126-5129

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Journal Article] Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+Foxp3+T regulatory cells2009

    • Author(s)
      Brenk M, Scheler M, Koch S, Neumann J, Takikawa O, Hacker G, Bieber T, von Bubnoff D
    • Journal Title

      J Immunol

      Volume: 183 Pages: 145-154

    • DOI

      10.4049/jimmunol.0803277

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Journal Article] Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes : functional involvement of the CTLA-4/B7 and CCL22/CCR4 interactions2009

    • Author(s)
      Onodera T, Jang MH, Guo Z, Yamasaki M, Hirata T, Bai Z, Tsuji NM, Nagakubo D, Yoshie O, Sakaguchi S, Takikawa O, Miyasaka M
    • Journal Title

      J Immunol

      Volume: 183 Pages: 5608-5614

    • DOI

      10.4049/jimmunol.0804116

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Journal Article] Proinflammatory cytokine interferon-gamma increases induction of indoleamine 2,3-dioxygenase in monocytic cells primed with amyloid beta peptide 1-42 : implications for the pathogenesis of Alzheimer's disease2009

    • Author(s)
      Yamada A, Akimoto H, Kagawa S, Guillemin GJ, Takikawa O.
    • Journal Title

      J Neurochem. 110

      Pages: 791-800

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Journal Article] Proinflammatory cytokine interferon-gamma increases induction of indoleamine 2, 3-dioxygenase in monocytic cells primed with amyloid beta peptide 1-42 : implications for the pathogenesis of Alzheimer's disease2009

    • Author(s)
      Yamada A, Akimoto H, Kagawa S, Guillemin GJ, Takikawa O.
    • Journal Title

      J Neurochem

      Volume: 110 Pages: 791-800

    • DOI

      10.1111/j.1471-4159.2009.06175.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Journal Article] Hemoglobin induces the expression of indoleamine 2, 3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-kappaB and the generation of reactive oxygen species2009

    • Author(s)
      Ogasawara N, Oguro T, Sakabe T, Matsushima M, Takikawa O, Isobe K, Nagase F
    • Journal Title

      J Cell Biochem

      Volume: 108 Pages: 716-725

    • DOI

      10.1002/jcb.22308

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Journal Article] Role of the immunosuppressive enzyme indoleamine 2, 3-dioxygenase in the progression of ovarian carcinoma2009

    • Author(s)
      Inaba T, Ino K, Kajiyama H, Yamamoto E, Shibata K, Nawa A, Nagasaka T, Akimoto H, Takikawa O, Kikkawa F
    • Journal Title

      Gynecol Oncol

      Volume: 115 Pages: 185-192

    • DOI

      10.1016/j.ygyno.2009.07.015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Journal Article] Free iron ions decrease indoleamine 2, 3-dioxygenase expression and reduce IFNgamma-induced inhibition of Chlamydia trachomatis infection2009

    • Author(s)
      Krausse-Opatz B, Wittkop U, Gutzki FM, Schmidt C, Jurgens-Saathoff B, Meier S, Beckmann B, Takikawa O, Morgan MA, Tsikas D, Stichtenoth DO, Wagner AD, Zeidler H, Kohler L
    • Journal Title

      Microb Pathog

      Volume: 46 Pages: 289-297

    • DOI

      10.1016/j.micpath.2009.03.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Patent] アルツハイマー病の発症を予測する方法2015

    • Inventor(s)
      斎藤嘉朗、新飯田俊平、滝川 修
    • Industrial Property Rights Holder
      斎藤嘉朗、新飯田俊平、滝川 修
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015
    • Acquisition Date
      2017
    • Data Source
      KAKENHI-PROJECT-15K08326
  • [Patent] 軽度認知障害を検査する方法2015

    • Inventor(s)
      滝川修、新飯田俊平、檜垣小百合、松本健治、茅野光範
    • Industrial Property Rights Holder
      滝川修、新飯田俊平、檜垣小百合、松本健治、茅野光範
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-173901
    • Filing Date
      2015-09-03
    • Data Source
      KAKENHI-PROJECT-15K08326
  • [Patent] 微小生体組織片の作製装置、作製方法、及び化合物のスクリーニング方法2014

    • Inventor(s)
      滝川修、吉見立也、田中耕一、川畑慎一郎
    • Industrial Property Rights Holder
      滝川修、吉見立也、田中耕一、川畑慎一郎
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-212627
    • Filing Date
      2014-10-17
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Patent] 化学・物理現象検出方法及びその装置2014

    • Inventor(s)
      滝川修、奥野海良人、吉見立也、澤田和明、奥村弘一
    • Industrial Property Rights Holder
      滝川修、奥野海良人、吉見立也、澤田和明、奥村弘一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-05-28
    • Overseas
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Patent] 微小生体組織片の作製装置、作製方法、及び化合物のスクリーニング方法2014

    • Inventor(s)
      滝川修、吉見立也、田中耕一、川畑慎一郎
    • Industrial Property Rights Holder
      滝川修、吉見立也、田中耕一、川畑慎一郎
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-10-17
    • Data Source
      KAKENHI-PROJECT-24510322
  • [Patent] 化学・物理現象検出方法及びその装置2013

    • Inventor(s)
      滝川修、奥野海良人、吉見立也、澤田和明、奥村弘一
    • Industrial Property Rights Holder
      滝川修、奥野海良人、吉見立也、澤田和明、奥村弘一
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-112444
    • Filing Date
      2013-05-29
    • Data Source
      KAKENHI-PROJECT-24510322
  • [Patent] 化学・物理現象検出方法及びその装置2013

    • Inventor(s)
      滝川修、奥野海良人、吉見立也、澤田和明、奥村弘一
    • Industrial Property Rights Holder
      滝川修、奥野海良人、吉見立也、澤田和明、奥村弘一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-05-29
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Patent] アルツハイマー病の発症を予測する方法2012

    • Inventor(s)
      滝川修・奥野海良人・その他5名
    • Industrial Property Rights Holder
      滝川修・奥野海良人・その他5名
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-151620
    • Filing Date
      2012-07-05
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Patent] アルツハイマー病の診断マーカー、アルツハイマー病の予防及び治療薬のスクリーニング方法並びにアルツハイマー病の診断方法2010

    • Inventor(s)
      滝川修、曽我朋義
    • Industrial Property Rights Holder
      財団法人ヒューマンサイエンス財団
    • Filing Date
      2010-05-17
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Patent] アルツハイマー病の診断マーカー、アルツハイマー病の予防及び治療薬のスクリーニング方法並びにアルツハイマー病の診断方法2010

    • Inventor(s)
      滝川修曽我朋義
    • Industrial Property Rights Holder
      財団法人ヒューマンサイエンス財団
    • Industrial Property Number
      2010-113496
    • Filing Date
      2010-05-17
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Patent] 含硫化合物を有効成分として含有するIDO阻害剤2009

    • Inventor(s)
      滝川修、浅井章良、松野研司、海野雄加
    • Industrial Property Rights Holder
      独立行政法人国立長寿医療研究センター・ファルマIP
    • Industrial Property Number
      2009-205484
    • Filing Date
      2009-09-07
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Patent] ベンゾイミダゾール誘導体を有効成分とするIDO阻害剤2009

    • Inventor(s)
      滝川修、浅井章良、松野研司、海野雄加
    • Industrial Property Rights Holder
      独立行政法人国立長寿医療研究センター・ファルマIP
    • Industrial Property Number
      2009-133633
    • Filing Date
      2009-06-03
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] 「医療・健康産業を変える革新技術:細胞特異的リキッドバイオプシー(アルツハイマー病を例として)」2017

    • Author(s)
      滝川 修
    • Organizer
      日本化学会第97春季年会(2017)
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K08326
  • [Presentation] 「脳リキッドバイオプシー」2017

    • Author(s)
      滝川 修
    • Organizer
      2017年度日本老年病医学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K08326
  • [Presentation] 脳リキッドバイオプシー(アルツハイマー病を例として)」2017

    • Author(s)
      滝川 修
    • Organizer
      第22回日本フードファクター学会学術集会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K08326
  • [Presentation] Trp supplementation decreases KYNA/QA ratio in the mouse brain.2015

    • Author(s)
      Okuno A, Yoshimi T, Mikawa R, Takikawa O.
    • Organizer
      2015 ISTRY Conference
    • Place of Presentation
      Grand Rapids, USA.
    • Year and Date
      2015-11-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08326
  • [Presentation] AIMS: 親和性化合物イメージング質量分析スクリーニングシステム2015

    • Author(s)
      吉見立也、川畑慎一郎、奥野海良人、三河隆太、田中耕一、滝川修
    • Organizer
      BMB2015(分子生物学会、生化学会合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-03
    • Data Source
      KAKENHI-PROJECT-15K08326
  • [Presentation] マイクロバイオ化学センサによる健康管理2015

    • Author(s)
      澤田和明、奥野海良人、滝川修、奥村弘一、服部敏明
    • Organizer
      日本機械学会第7回マイクロ・ナノ工学シンポジウム
    • Place of Presentation
      新潟
    • Year and Date
      2015-10-30
    • Data Source
      KAKENHI-PROJECT-15K08326
  • [Presentation] Development of High-speed and Super Sensitive Device for Detection of Amyloid-β Peptide Using an Ion Image Sensor.2015

    • Author(s)
      Okuno A, Yoshimi T, Okumura K, Sawada K, Takikawa O.
    • Organizer
      26th IEEE International Symposium on Micro-NanoMehatronics and Human Science in 2015
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2015-11-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08326
  • [Presentation] ヒト血清中のアミロイドβ分解活性の性状解析2015

    • Author(s)
      三河隆太、奥野海良人、吉見立也、滝川修
    • Organizer
      第38回日本基礎老化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2015-06-14
    • Data Source
      KAKENHI-PROJECT-15K08326
  • [Presentation] マウスにおけるトリプトファン摂取が神経保護物質キヌレン酸および神経毒キノリン酸の脳内および血液レベルに及ぼす影響2015

    • Author(s)
      奥野海良人、三河隆太、吉見立也、滝川修
    • Organizer
      日本アミノ酸学会第9回学術大会(JSAAS2011)
    • Place of Presentation
      彦根
    • Year and Date
      2015-10-24
    • Data Source
      KAKENHI-PROJECT-15K08326
  • [Presentation] ヒト血清中のアミロイドβ分解活性の同定2014

    • Author(s)
      三河隆太、奥野海良人、高柳亜紀子、吉見立也、滝川修
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-18
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] Blood biomarkers for Alzheimer’s disease revealed by capillary electrophoresis/mass spectrometry (CE/MS)-based metabolomics.2014

    • Author(s)
      Kayano M, Hirayama A, Washimi Y, Bundo M, Sakurai T, Tokuda H, Soga T, Niida S, Takikawa O.
    • Organizer
      Tenth Annual International Conference of the Metabolomics Society
    • Place of Presentation
      Tsuruoka, Japan.
    • Year and Date
      2014-06-25
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] New modulator of the tumoural immuno escape via Indoleamin 2,3-dioxygenase (IDO) inhibition.2014

    • Author(s)
      Antonio Coluccia, Giuseppe La Regina, Okuno A, Takikawa O, Romano Silvestri.
    • Organizer
      XXV CONGRESSO NAZIONALE DELLA SCI “SCI2014”
    • Place of Presentation
      Rend CS, Italy.
    • Year and Date
      2014-09-07
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] Characterization of Amyloid-β Degrading Activity in Human Serum.2014

    • Author(s)
      Mikawa R, Okuno A, Takayanagi A, Okada K, Yoshimi T, Takikawa O.
    • Organizer
      日本基礎老化学会第37回大会
    • Place of Presentation
      東浦
    • Year and Date
      2014-06-26
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] イメージング質量分析の最前線:創薬と生命科学への応用2014

    • Author(s)
      滝川修、吉見立也
    • Organizer
      第87回生化学会大会フォーラム4F04
    • Place of Presentation
      京都
    • Year and Date
      2014-10-18
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] Characterization of Amyloid-βDegrading Activity in Human Serum.2014

    • Author(s)
      三河隆太、吉見立也、奥野海良人、岡田健、高柳亜紀子、滝川修
    • Organizer
      第6回NAGOYAグローバルリトリート
    • Place of Presentation
      東浦
    • Data Source
      KAKENHI-PROJECT-24510322
  • [Presentation] Implications of brain microvessel endothelial cell-derived amyloid β peptide in cerebral amyloid angiopathy associated with Alzheimer’s disease.2013

    • Author(s)
      Takikawa O, Mikawa R, Okuno A, Yoshimi T, Okada K, Takayanagi A.
    • Organizer
      Alzheimer’s disease Association International Conference (AAIC) 2013
    • Place of Presentation
      Boston, USA
    • Data Source
      KAKENHI-PROJECT-24510322
  • [Presentation] 脳血管細胞によるAβ産生と脳アミロイド血管症2013

    • Author(s)
      三河隆太、奥野海良人、岡田健、高柳亜紀子、吉見立也、滝川修
    • Organizer
      第35回神経組織培養研究会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-24510322
  • [Presentation] 血管内皮細胞によるAβ産生調節機構:脳アミロイド血管症におけるその病態生理学的意義2013

    • Author(s)
      三河隆太、吉見立也、奥野海良人、岡田健、高柳亜紀子、滝川修
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24510322
  • [Presentation] 経管栄養施行中の重症心身障害児(者)の栄養障害と免疫機能 -インドールアミン酸素添加酵素(IDO)との関連について-2013

    • Author(s)
      大森啓充、滝川修、眞山義民、奥野海良人、山﨑雅美、福場浩正、村田芳夫、松本信夫、品川友江、宮地隆史、住元了、鈴木修一、 宮野前健、児玉浩子
    • Organizer
      第35回日本臨床栄養学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] アルツハイマー病モデルAPP/Tauマウスにおける血漿の脂質メタボローム解析2012

    • Author(s)
      石川将己、前川京子、田島陽子、村山真由子、徳江繭子、最上(西巻)知子、中西広樹、池田和貴、有田誠、田口良、キョウ建生、奥野海良人、新飯田俊平、滝川修、斉藤嘉朗
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] 新規IDO阻害剤の活性評価2012

    • Author(s)
      李シン(昕)、田中実、滝川修、横山祐作
    • Organizer
      第40回構造活性相関シンポジウム
    • Place of Presentation
      岡崎
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] Aβ Production from Reactive Astrocytes Induced by Endogenous Neurotoxin Quinolinic Acid: A New Aspect of Alzheimer’s Disease.2012

    • Author(s)
      Okuno A, Zhang G, Yoshimi T, Mikawa R, Takikawa O
    • Organizer
      Alzheimer’s disease Association International Conference (AAIC) 2012
    • Place of Presentation
      Vancouver, Canada
    • Data Source
      KAKENHI-PROJECT-24510322
  • [Presentation] Pathogenic role of IDO in Alzheimer’s disease : Astrocytes but not neurons are responsible for the increase of amyloid β peptide induced by neurotoxin quinolinic acid2012

    • Author(s)
      Okuno A, Yoshimi T, Okada K, Mikawa R, Takayanagi A, Takikawa O
    • Organizer
      The 13th ISTRY (International Society for Tryptophan Research) conference
    • Place of Presentation
      Sydney, Australia
    • Data Source
      KAKENHI-PROJECT-24510322
  • [Presentation] アルツハイマー病モデルAPP/Tauマウスの脳組織における脂質メタボローム解析2012

    • Author(s)
      田島陽子、前川京子、村山真由子、石川将己、徳江繭子、最上(西巻)知子、中西広樹、池田和貴、有田誠、田口良、キョウ建生、奥野海良人、新飯田俊平、滝川修、斉藤嘉朗
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] NMRを用いたアルツハイマー病モデルマウスのメタボローム解析2012

    • Author(s)
      福原 潔、大野彰子、太田庸介、前川京子、奥田晴宏、栗原正明、奥野海良人、新飯田俊平、斎藤嘉朗、滝川 修
    • Organizer
      第65回日本酸化ストレス学会
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] 反応性アストロサイトによるアミロイドβペプチド産生機構2012

    • Author(s)
      吉見立也、奥野海良人、岡田健、三河隆太、高柳亜紀子、滝川修
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24510322
  • [Presentation] CE/MSメタボロミクスによるアルツハイマー病の尿、血液及び脳バイオマーカーの検出2011

    • Author(s)
      滝川修、新飯田俊平、曽我朋義
    • Organizer
      第6回メタボロームシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-13
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] Development of prophylaxis and therapy for vascular dementia by anti-E-selectin antibody using the mouse model2011

    • Author(s)
      Adachi K, Kunimoto S, Takeda K, Ohtani T, Watanabe A, Takikawa O, Maruyama W, Wakita H
    • Organizer
      The Asia-Pacific Interdisciplinary Research Conference 2011
    • Place of Presentation
      Toyohashi
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] Endogenous neurotoxin quinolinic acid may play a primary role in the pathology of Alzheimer's disease by killing neurons and increasing the amyloid beta peptide levels in the hippocampus2011

    • Author(s)
      Takikawa O, Kagawa S, Okuno A, Yokoi H, Zhang Q
    • Organizer
      AD/PD2011(アルツハイマー病・パーキンソン病2011)
    • Place of Presentation
      バルセロナ(スペイン)
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] Detection of urine, blood, and brain biomarkers for Alzheimer's disease by capillary electrophoresis/mass spectrometry(CE-MS)-based metabolomic analysis2011

    • Author(s)
      Takikawa O, Niida S, Soga T.
    • Organizer
      Seventh International Conference of the Metabolomics Society
    • Place of Presentation
      Cairns, Australia
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] アルツハイマー病根本治療薬の開発を目指して2011

    • Author(s)
      滝川修
    • Organizer
      第47回シグナル伝達医学グローバルCOE学術講演会
    • Place of Presentation
      神戸
    • Year and Date
      2011-08-12
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] 反応性アストロサイトによるアミロイドβペプチド産生機構2011

    • Author(s)
      奥野海良人、張桂琴、吉見立也、三河隆太、高柳亜紀子、滝川修
    • Organizer
      第33回日本トリプトファン研究会
    • Place of Presentation
      船橋
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] Development of prophylaxis and therapy for vascular dementia by anti-E-selectin antibody using the mouse model2011

    • Author(s)
      Adachi K, Kunimoto S, Takeda K, Ohtani T, Watanabe A, Takikawa O, Maruyama W, Wakita H
    • Organizer
      The Asia-Pacific Interdisciplinary Research Conference 2011
    • Place of Presentation
      豊橋
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] 内在性神経毒キノリン酸による海馬アミロイドβペプチドの増加機構:神経細胞ではなく反応アストロサイトに因る2011

    • Author(s)
      滝川修、奥野海良人、張桂琴、横井寛、吉見立也、三河隆太
    • Organizer
      第84回日本生化学大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] Astrocytes but not neurons are responsible for the hippocampal increase of amyloidβpeptide induced by neurotoxin quinolinic acid2011

    • Author(s)
      Okuno A, Zhang G, Yokoi H, Takikawa O
    • Organizer
      AAIC 2011
    • Place of Presentation
      Paris, France
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] キノリン酸によるアミロイドβペプチドの増加機構-神経細胞ではなく反応性アストロサイトに因る2011

    • Author(s)
      奥野海良人、張桂琴、横井寛、吉見立也、滝川修
    • Organizer
      日本基礎老化学会第34回大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] 反応性アストロサイトによるAβ産生-アルツハイマー病のアミロイド代謝異常に関する新知見2011

    • Author(s)
      滝川修、奥野海良人、張桂琴、横井寛、吉見立也
    • Organizer
      日本基礎老化学会第34回大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] Astrocytes but not neurons are responsible for the hippocampal increase of amyloid ss peptide induced by neurotoxin quinolinic acid2011

    • Author(s)
      Okuno A, Zhang G, Yokoi H, Takikawa O
    • Organizer
      Alzheimer's Association International Conference 2011
    • Place of Presentation
      Paris, France
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] 反応性アストロサイトによるアミロイドβペプチド産生2011

    • Author(s)
      張桂琴、奥野海良人、横井寛、吉見立也、滝川修
    • Organizer
      日本基礎老化学会第34回大会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-16
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] 反応性アストロサイトによるアミロイドβペプチド産生2011

    • Author(s)
      吉見立也、張桂琴、奥野海良人、横井寛、三河隆太、滝川修
    • Organizer
      第84回日本生化学大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] 内因性神経毒キノリン酸で誘導される反応性アストロサイトによるアミロイドβペプチド産生2011

    • Author(s)
      張桂琴、奥野海良人、吉見立也、三河隆太、高柳亜紀子、滝川修
    • Organizer
      第33回日本トリプトファン研究会
    • Place of Presentation
      船橋
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] Detection of urine, blood, and brain biomarkers for Alzheimer's disease by capillary electrophoresis/mass spectrometry (CE-MS)-based metabolomic analysis2011

    • Author(s)
      Takikawa O, Niida S, Soga T
    • Organizer
      Seventh International Conference of the Metabolomics Society
    • Place of Presentation
      Cairns, Australia
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] 内在性神経毒キノリン酸によるアミロイドβペプチド増加機構とその病態生理学的意義2010

    • Author(s)
      奥野海良人、香川正太、横井寛、張桂琴、滝川修
    • Organizer
      第32回日本トリプトファン研究会学術集会
    • Place of Presentation
      彦根
    • Year and Date
      2010-12-05
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] Endogenous neurotoxin quinolinic acid may play a primary role in the pathology of Alzheimer's disease by increasing the amyloid beta peptide levels2010

    • Author(s)
      Takikawa O, Kagawa S, Okuno A, Yokoi H, Zhang Q
    • Organizer
      ICAD2010(国際アルツハイマー病学会2010)
    • Place of Presentation
      ホノルル(米国)
    • Year and Date
      2010-07-05
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] IDO阻害活性を有するS-benzylisothiourea誘導体の構造活性相関2010

    • Author(s)
      山崎寛史、松野研司、高井一成、井坂吉伸、海野雄加、佐藤雅之、浅井章良、滝川修
    • Organizer
      第25回農薬デザイン研究会
    • Place of Presentation
      浜松
    • Year and Date
      2010-11-05
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] LPSの抹消投与による脳内炎症モデルの作製:アルツハイマー病の理解を目指して2010

    • Author(s)
      横井寛、奥野海良人、張桂琴、滝川修
    • Organizer
      第32回日本トリプトファン研究会学術集会
    • Place of Presentation
      彦根
    • Year and Date
      2010-12-05
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] アルツハイマー病とトリプトファン代謝異常:神経毒キノリン酸による神経細胞死とアミロイドβペプチド増加2010

    • Author(s)
      滝川修、香川正太、張桂琴、横井寛
    • Organizer
      日本基礎老化学会第33回大会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-06-18
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] アルツハイマー病で見られるトリプトファン代謝異常の病態生理学的意義:神経毒キノリン酸のダークパワー2010

    • Author(s)
      滝川修
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] IDO阻害活性を有するS-benzylisothiourea誘導体の構造活性相関2010

    • Author(s)
      松野研司、高井一成、井坂吉伸、海野雄加、佐藤雅之、滝川修、浅井章良
    • Organizer
      第29回メディシナルケミストリーシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2010-11-17
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] Assay development and screening for new chemical entities as IDO inhibitors2010

    • Author(s)
      K Takai, Y Isaka, Y Unno, K Matsuno, M Sato, O Takikawa, A Asai
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] Endogenous neurotoxin quinolinic acid may play a primary role in the pathology of Alzheimer's disease by increasing the amyloid beta peptide levels2010

    • Author(s)
      Takikawa O
    • Organizer
      ICNCC 2010(第1回国際神経組織培養研究会)
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2010-06-25
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] Assay development and screening for new chemical entities as IDO Inhibitors2010

    • Author(s)
      Takai K, Isaka Y, Unno Y, Matsuno K, Sato M, Takikawa O, Asai A
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] アルツハイマー病で見られるトリプトファン代謝異常の病態生理学的意義 : 神経毒キノリン酸のダークパワー2010

    • Author(s)
      滝川修
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] Neurotoxin quinolinic acid produced in overactivated microglia may contribute to the progression of Alzheimer's disease.2009

    • Author(s)
      Kagawa S, Yamada A, Akimoto H, Yokoi H, Guillemin GJ, Takikawa O
    • Organizer
      第12回国際トリプトファン研究会
    • Place of Presentation
      フローレンス(イタリア)
    • Year and Date
      2009-07-10
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] Neurotoxin quinolinic acid produced in overactivated microglia may contribute to the progression of Alzheimer's disease2009

    • Author(s)
      Kagawa S, Yamada A, Akimoto H, Yokoi H, Guillemin GJ, Takikawa O
    • Organizer
      第12回国際トリプトファン研究会
    • Place of Presentation
      フローレンス(イタリア)
    • Year and Date
      2009-07-10
    • Data Source
      KAKENHI-PROJECT-21590353
  • [Presentation] Kinetic and protein-ligand interaction studies of human tryptophan 2,3-dioxygenase, identified the modulation of enzymatic reactions by tryptophan.

    • Author(s)
      岡田健、三河隆太、奥野海良人、高柳亜紀子、山岸まゆみ、吉見立也、滝川修
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] Lipidomic analysis of brain and plasma from a mouse model of Alzheimer’s disease.

    • Author(s)
      Tajima Y, Maekawa K, Ishikawa M, Murayama M, Nishimaki-Mogami T, Nakanishi1 H, Ikeda K, Arita M, Taguchi R, Gong J, Okuno A, Niida S, Takikawa O, Saito Y.
    • Organizer
      第53回国際脂質生化学会
    • Place of Presentation
      Banff, Canada
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] 血管内皮細胞によるAβ産生調節機構:脳アミロイド血管症におけるその病態生理学的意義

    • Author(s)
      三河隆太、吉見立也、奥野海良人、岡田健、高柳亜紀子、滝川修
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] Pathogenic role of IDO in Alzheimer’s disease: Astrocytes but not neurons are responsible for the increase of amyloid β peptide induced by neurotoxin quinolinic acid.

    • Author(s)
      Okuno A, Yoshimi T, Okada K, Mikawa R, Takayanagi A, Takikawa O.
    • Organizer
      第13回国際トリプトファン研究会
    • Place of Presentation
      Sydney, Australia
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] トリプトファン代謝異常と疾患:アルツハイマー病とがん免疫抑制作用

    • Author(s)
      滝川修
    • Organizer
      第52回日本栄養・食糧学会近畿支部大会
    • Place of Presentation
      彦根
    • Invited
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] メタボロミクスによるアルツハイマー病早期発見診断マーカーの探索

    • Author(s)
      滝川修、新飯田俊平、平山明由、曽我朋義
    • Organizer
      第8回メタボロームシンポジウム
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] トリプトファン代謝異常の病態生理学的意義:アルツハイマー病とがんを中心に

    • Author(s)
      滝川修
    • Organizer
      第17回「アミノ酸セミナー:基礎と臨床を結ぶ会」
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] Characterization of Amyloid-βDegrading Activity in Human Serum.

    • Author(s)
      三河隆太、吉見立也、奥野海良人、岡田健、高柳亜紀子、滝川修
    • Organizer
      第6回NAGOYAグローバルリトリート
    • Place of Presentation
      東浦
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] Implications of brain microvessel endothelial cell-derived amyloid β peptide in cerebral amyloid angiopathy associated with Alzheimer’s disease.

    • Author(s)
      Takikawa O, Mikawa R, Okuno A, Yoshimi T, Okada K, Takayanagi A.
    • Organizer
      Alzheimer’s disease Association International Conference (AAIC) 2013
    • Place of Presentation
      Boston, America.
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] Benzimidazole構造を有する新規indoleamine 2,3-dioxygenase(IDO)阻害剤の合成と活性評価

    • Author(s)
      福田美和、脇稔、浅井章良、滝川修、宮地弘幸、松野研司
    • Organizer
      第31回メディシナルケミストリーシンポジウム
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] Biological Evaluation on New Inhibitors of Indoleamine 2, 3-Dioxygenase.

    • Author(s)
      Li X, Tanaka M, Takikawa O, Yokoyama Y.
    • Organizer
      The Ninth China-Japan Joint Symposium on Drug Design and Development
    • Place of Presentation
      Guilin, China
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] 凍結組織切片のイメージング質量分析による病原蛋白PET診断薬開発システム

    • Author(s)
      滝川修、吉見立也、田中耕一、川畑慎一郎
    • Organizer
      メディカルジャパン2015大阪、アカデミックフォーラム A-4
    • Place of Presentation
      インテックス大阪
    • Year and Date
      2015-02-04 – 2015-02-06
    • Data Source
      KAKENHI-PROJECT-24510322
  • [Presentation] 脳血管細胞によるAβ産生と脳アミロイド血管症

    • Author(s)
      三河隆太、奥野海良人、岡田健、高柳亜紀子、吉見立也、滝川修
    • Organizer
      第35回神経組織培養研究会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] 反応性アストロサイトによるアミロイドβペプチド産生機構

    • Author(s)
      吉見立也、奥野海良人、岡田健、三河隆太、高柳亜紀子、滝川修
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] Development of High-speed and Super Sensitive Device for Detection of Amyloid-β Peptide Using an Ion Image Sensor.

    • Author(s)
      Okuno A, Yoshimi T, Okumura K, Sawada K, Takikawa O.
    • Organizer
      IEEE International Symposium on Micro-NanoMechatronics and Human Science(MHS) 2014
    • Place of Presentation
      Nagoya,Japan.
    • Year and Date
      2014-11-10 – 2014-11-12
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] Organ Specificity of Tryptophan Metabolism in Humans.

    • Author(s)
      Takikawa O.
    • Organizer
      第13回国際トリプトファン研究会サテライトシンポジウム
    • Place of Presentation
      Brisbane, Australia
    • Invited
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] ヒトTryptophan 2,3-dioxygenaseのアロステリック効果による酵素反応調節機構

    • Author(s)
      岡田健、三河隆太、奥野海良人、吉見立也、滝川修
    • Organizer
      第35回日本トリプトファン研究会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] indoleamine 2,3-dioxygenase (IDO) 阻害活性を有するbenzimidazole系化合物の創製

    • Author(s)
      福田美和、脇稔、浅井章良、滝川修、宮地弘幸、松野研司
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] Aβ Production from Reactive Astrocytes Induced by Endogenous Neurotoxin Quinolinic Acid : A New Aspect of Alzheimer’s Disease.

    • Author(s)
      Okuno A, Zhang G, Yoshimi T, Mikawa R, Takikawa O.
    • Organizer
      Alzheimer’s disease Association International Conference (AAIC) 2012
    • Place of Presentation
      Vancouver, Canada
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] トリプトファン代謝酵素IDO・TDOと免疫抑制

    • Author(s)
      滝川
    • Organizer
      第34回癌免疫外科研究会
    • Place of Presentation
      岡山
    • Invited
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] 反応性アストロサイトによるAβ産生:アルツハイマー病のアミロイド代謝異常に関する新知見

    • Author(s)
      滝川修
    • Organizer
      Neuro2013
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] 血管内皮細胞におけるAβ産生機構と脳アミロイド血管症

    • Author(s)
      三河隆太、吉見立也、奥野海良人、岡田健、高柳亜紀子、滝川修
    • Organizer
      第36回日本基礎老化学会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer’s disease.

    • Author(s)
      Tajima Y, Maekawa Keiko, Ishikawa M, Murayama M, Senoo Y, Nishimaki-Mogami T, Nakanishi H, Kazutaka I, Arita M, Taguchi R, Okuno A, Mikawa R, Niida S, Takikawa O, Saito Y.
    • Organizer
      The 9th Annual Conference of the Metabolomics Society
    • Place of Presentation
      Glasgow, Scotland
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] The pathological role of IDO-medicated tryptophan metabolism in Alzheimer’s disease.

    • Author(s)
      Takikawa O
    • Organizer
      旭川医科大学 第1回教育研究センター主催国際シンポジウム:トリプトファン代謝と脳機能/疾患
    • Place of Presentation
      旭川
    • Invited
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] アルツハイマー病モデルマウスの脳組織及び血漿における脂質メタボローム解析

    • Author(s)
      田島陽子、前川京子、石川将己、村山真由子、妹尾勇弥、最上(西巻)知子、中西広樹、池田和貴、有田誠、田口良、檜垣小百合、奥野海良人、新飯田俊平、滝川修、斎藤嘉朗
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24590397
  • [Presentation] 血中miRNAとEndothelial Microparticles - microRNAs in the endothelial microparticles-

    • Author(s)
      新飯田俊平、山本誠士、村松昌、東英梨月、本山昇、滝川修
    • Organizer
      第4回日本RNAi研究会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-24590397
  • 1.  YOSHIDA Ryotaro (10124760)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 2.  TONE Sigenobu (70211399)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  OKUNO Alato (50623980)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 31 results
  • 4.  YAMAMOTO Naoki (10260176)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  MIWA Soichi (40157706)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  KAGAWA Syota (30463201)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 7.  YOSHIMI Tatsuya (30277256)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 8.  HABARA Akemi (00168890)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  USHIO Yumiko (90193862)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  VERKHSHA V (80270578)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  HATTORI Yuichi (50156361)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  安井 浩明 (80230209)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  SUGIYAMA Masasya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  KAWADA Junichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 15.  MABUCHI Yasushi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  NAKANISHI Hiroki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  OKUDA Haruhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  OHNO Akiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  松原 悦朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  伊藤 嘉規
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  鳥居 ゆか
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  井箟 一彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  小澤 敬也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  嵯峨 泰
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  藤井 敏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  石川 吉伸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  有田 誠
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  田口 良
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  小郷 尚久
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  福原 潔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  鈴木 英治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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