OHMORI Shigeru 大森栄

Researcher Number	70169069
Other IDs
Affiliation (based on the past Project Information) *help	2014 – 2018: 信州大学, 学術研究院医学系(医学部附属病院), 教授 2003 – 2016: 信州大学, 医学部附属病院, 教授 2011: 信州大学, 医学部付属病院, 教授 2010: 信州大学, 医学部・附属病院, 教授 2004: 信州大学, 医学部, 教授 … More 1998: 千葉大学, 医学部附属病院, 助教授 1993 – 1998: 千葉大学, 医学部・附属病院, 助教授 1997: 千葉大学, 医学部・付属病院, 助教授 1994: 千葉大学, 医学部付属病院薬剤部, 助教授 1994: 千葉大学, 医学部附属病院, 助教授 1993 – 1994: 千葉大学, 医学部・付属病院薬剤部, 助教授 1991 – 1992: 千葉大学, 薬学部, 助手 1986: Fac. of Pharmaceut. Sci., Chiba Univ., Research Assistant, 薬学部, 教務職員 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / 応用薬理学・医療系薬学 / Biological pharmacy Except Principal Investigator Medical pharmacy / 応用薬理学・医療系薬学 / Environmental and hygienic pharmacy / 医薬分子機能学
Keywords	Principal Investigator サル / 肝細胞 / 肝 / P450 / 漢方薬 / 相互作用 / チトクロムP450 / 薬物代謝 / 胚性幹細胞 / HNF-3β … More / 薬物動態 / 分化 / シトクロムP450 / 薬物代謝酵素 / CYP3A / ビリルビン尿症 / ラット / ノトプテロール / マトリゲル / GATA-4 / 代謝学 / ヒト人工多能性幹細胞 / iPS細胞 / 腸管上皮細胞 / 低分子化合物 / 分化誘導 / 胆管上皮細胞 / ヒトES細胞 / 脳 / シクロゾーム / ミクロゾーム / チトクロームP450 / Monkey / Brain / Liver / Cytochrome P450 / Drug metabolism / Microsomes / マウス / 肝芽細胞 / CYP3A8 / CYP3A66 / 胚様体 / 薬物トランスポーター / Cyplal / Cyp3all / Cyp7al / Cyp7bl / mouse / monkey / embryonic stem cell / hepatocyte / differentiate / hepatoblast / cyochrome P450 / ヒト胎児肝細胞 / 糖質コルチコイド / SULT1E1 / CYP3A7 / 発現制御 / 発現調節因子 / エピジェネティクス / グルココルチコイド受容体 … More Except Principal Investigator CYP3A7 / 薬物代謝酵素 / ヒト胎児肝細胞 / CYP3A4 / 薬物代謝 / 薬物動態 / リファンピシン / 胎児毒性 / CYP / drug metabolism / GST / 肝細胞 / シトクロムP450 / CYP3A / 胎児 / ヒトiPS細胞 / ラット / 分化 / グルタチオンS-トランスフェラーゼ / ステロイド代謝 / steroid metabolism / デキサメタゾン / グルココルチコイド受容体 / P-450 / 胎児肝 / チトクロ-ムPー450 / Pー450IA / 腎障害 / GST-α / GST-π / 代謝学 / ヒト胎児 / 転写活性 / コアクチベーター / コリプレッサー / 低酸素 / 低酸素誘導因子 / pregnane X receptor / 転写因子 / hepatocyte nuclear factor 4α / peroxisome proliferator activated receptor γ coactivator 1α / 妊婦 / 薬物動態予測モデル / 胚性幹細胞 / デスフェロキサミン / ケモプリベンション / ビタミン K / iPS 細胞 / PIVKA-II / VKORC1 / ビタミンKサイクル / 発がん予防機構 / 胚盤胞補完法 / サルiPS細胞 / 異種動物間キメラ / ラットiPS細胞 / カニクイザル / マーモセット / tk-NOGマウス / TK-NOGマウス / ES細胞 / FAH / 発現解析 / Rituximab / infusion reaction / monoclonal antibody / インフュージョンリアクション / 抗体医薬 / リツキシマブ / 分子標的薬 / 薬物相互作用 / モノクローナル抗体製剤 / マクロファージ / 分化誘導 / 腸管上皮細胞 / 初回通過効果 / 薬物トランスポーター / 経口バイオアベイラビリティ / デバイス / 薬学 / iPS細胞 / 薬物動態学 / 人工多能性幹細胞 / トランスポーター / 低分子化合物 / スクラーゼ・イソマルターゼ / エステラーゼ / カルボキシルエステラーゼ / 遺伝子導入 / 発現 / 培養細胞 / P450 / グルタチオン S-トランスフェラーゼ / carboxyl esterase / glutathion S-transferase / CYP 450 / CO57 cells / esterase / CYP3A酵素 / スラロイド代謝 / ヒト胎児肝P450 / CYP enzymes / expression in COS-7 cells and TN-5 cells / fetal toxicity / RNA干渉法 / 正常ヒト胎児肝細胞 / オンコスタチンM / グルココルチコイド受容 / メチル化 / サイトケラチン7 / 移植 / RU-486 / human fetal liver cell / cytochrome P450 / dexamethasone / glucocorticoid receptor / rifampicin / RU486 / プレグネノロンX受容体 / HNF4α / PGC1α / エピジェネティクス / 妊娠 / 薬物療法 / 卵膜 / 培養 / 化学物質 / 発生毒性 / 催奇形性 / マウス / モルモット / ハムスター / サル / 種差 / 性差 / アイソザイム / 8-GTP / 代替法 / 胎仔培養 / invitro毒科学 / Whole embryo culture / Chemicals / Developmental toxicity / Teratogenicity / Drug metabolism / Experimantal animals / Isozyme Less

Elucidation of mechanisms underlying different glucocorticoid responses of drug-metabolizing enzymes, SULT1E1 and CYP3A7, in human fetal liver cellsPrincipal Investigator
- Principal Investigator
  
  OHMORI Shigeru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Shinshu University
Differentiation of human iPS cells into hepatocytes and enterocytes: Development of first pass effect assessment model
- Principal Investigator
  
  Matsunaga Tamihide
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagoya City University
Estimation of fetotoxicity of chemical compounds with human fetal liver cells and molecular basis of their toxicities
- Principal Investigator
  
  YAMAORI Satoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Shinshu University
Investigation of the infusion reaction development coursed by molecular target medicine prescription
- Principal Investigator
  
  NAKAMURA Katsunori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of the Ryukyus
  Nagoya City University
Generation of Monkey/Mouse Chimera with Monkey Liver by Interspecific Blastocyst Injection of Monkey induced Pluripotent Stem Cells
- Principal Investigator
  
  MATSUNAGA Tamihide
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagoya City University
Differentiation ofhuman iPS cells into hepatocytes and bile duct epithelial cells and application to drug development studyPrincipal Investigator
- Principal Investigator
  
  OHMORI Shigeru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Shinshu University
Chemopreventive effects of vitamin K cycle using human iPS cells
- Principal Investigator
  
  NAKAMURA Katsunori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagoya City University
  Shinshu University
ヒト胎児肝細胞におけるCYP3A分子種の発現変動要因の解明
- Principal Investigator
  
  MATSUNAGA Tamihide
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Shinshu University
妊娠と薬:胎児における薬物動態変動因子の解明
- Principal Investigator
  
  松永民秀
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Shinshu University
サル胚性幹細胞の肝細胞への分化と胎児薬物動態予測モデルの構築Principal Investigator
- Principal Investigator
  
  大森栄
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Shinshu University
Basic Study for Regenerative Medicine : Differentiate of Human Fetal Liver Cells and Application for Drug Pharmacokinetic Experiments
- Principal Investigator
  
  MATSUNAGA Tamihide
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Shinshu University
Basic Study for Regenerative Medicine : Differentiate of Embryonic Stem Cells to Hepatocytes and Expressions of Cytochrome P450 in the Differentiating CellsPrincipal Investigator
- Principal Investigator
  
  OHMORI Shigeru
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Shinshu University
医薬品適正使用を指向した診断マーカーとしての薬物代謝酵素の有用性に関する研究
- Principal Investigator
  
  北田光一
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
Studies on the prediction of fetal toxicity caused by drugs
- Principal Investigator
  
  KITADA Mitsukazu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
薬物間相互作用の予測に関する研究:漢方薬との相互作用を中心としてPrincipal Investigator
- Principal Investigator
  
  大森栄
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
最適な薬物投与設計を目指した薬物相互作用の予測に関する研究Principal Investigator
- Principal Investigator
  
  大森栄
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
Studies on prediction of fetal toxicity caused by drugs.
- Principal Investigator
  
  KITADA Mitsukazu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
Studies on the metabolism and toxicity of drugs using mammalian cells expressed in drug metabolism enzymes
- Principal Investigator
  
  SATOH Tetsuo
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Chiba University
Studies on the structure and function of cytochrome P450 in monkey brainPrincipal Investigator
- Principal Investigator
  
  OHMORI Shigeru
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
高ビリルビン尿症ラットの肝シトクロムP-450分子種変動機構の解明Principal Investigator
- Principal Investigator
  
  大森栄
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
胎児性肝チトクロ-ムPー450に関する薬理学的・毒性学的研究
- Principal Investigator
  
  金久保好男
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University
Resolving studies on mechanism of developmental toxicity induced by chemical substances in culture system
- Principal Investigator
  
  KITAGAWA Haruo
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Chiba University

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2006 2005

All Journal Article Presentation Book

[Book] 薬物代謝学医療薬学・医薬品開発の基礎として第3版2.薬物の代謝反応2010
- Author(s)
  大森栄(分担執筆)
- Total Pages
  26
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-22590133
[Book] 薬物代謝学医療薬学・医薬品開発の基礎として第3版2010
- Author(s)
  大森栄(分担執筆)
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-22390028
[Journal Article] A specific probe substrate for evaluation of CYP4A11 activity in human tissue microsomes and a highly selective CYP4A11 inhibitor: luciferin-4A and epalrestat2018
- Author(s)
  Yamaori Satoshi、Araki Noriyuki、Shionoiri Mio、Ikehata Kurumi、Kamijo Shinobu、Ohmori Shigeru、Watanabe Kazuhito
- Journal Title
  
  J. Pharmacol. Exp. Ther.
  
  Volume: 366 Pages: 446-457
- DOI
  10.1124/jpet.118.249557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08354, KAKENHI-PROJECT-16K08368
[Journal Article] 切迫早産治療薬としてニフェジピンが奏功した一例2016
- Author(s)
  小澤秀介, 小林愛子, 高津亜希子, 神田博仁, 山折　大, 塩沢丹里, 大森　栄
- Journal Title
  
  医療薬学
  
  Volume: 42 Pages: 202-208
- NAID
  130005440106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460167
[Journal Article] <i>In Vitro</i> Inhibition of CYP2C9-Mediated Warfarin 7-Hydroxylation by Iguratimod2015
- Author(s)
  Yamaori S, Takami K, Shiozawa A, Sakuyama K, Matsuzawa N, Ohmori S
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 38 Issue: 3 Pages: 441-447
- DOI
  10.1248/bpb.b14-00711
- NAID
  130004872267
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460167
[Journal Article] Histone deacetylase inhibitors promote hepatic differentiation of human induced pluripotent stem cells into hepatocyte-like cells.2014
- Author(s)
  Kondo Y, Iwao T, Yoshihashi S, Mimori K, Ogihara R, Nagata K, Kurose K, Saito M, Niwa T, Suzuki T, Miyata N, Ohmori S, Nakamura K, Matsunaga T.
- Journal Title
  
  PLoS One
  
  Volume: 9 Pages: 1-11
- DOI
  10.1371/journal.pone.0104010
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460193, KAKENHI-PROJECT-25460195, KAKENHI-PROJECT-26293036
[Journal Article] An efficient method for differentiation of human induced pluripotent stem cells into hepatocyte-like cells retaining drug metabolizing activity.2014
- Author(s)
  Kondo Y, Iwao T, Nakamura K, Sasaki T, Takahashi S, Kamada N, Matsubara T, Gonzalez FJ, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Toyoda M, Umezawa A, Nagata K, Matsunaga T, Ohmori S
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 29 Pages: 237-243
- NAID
  130004463382
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293036
[Journal Article] An Efficient Method for Differentiation of Human Induced Pluripotent Stem Cells into Hepatocyte-Like Cells Retaining Drug Metabolizing Activity.2014
- Author(s)
  Kondo Y, Iwao T, Nakamura K, Sasaki T, Takahashi S, Kamada N, Matsubara T, Gonzalez FJ, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Toyoda M, Umezawa A, Nagata K, Matsunaga T, Ohmori S.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 29 Pages: 237-243
- NAID
  130004463382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460193
[Journal Article] An Efficient Method for Differentiation of Human Induced Pluripotent Stem Cells into Hepatocyte-like Cells Retaining Drug Metabolizing Activity2014
- Author(s)
  Kondo Y, Iwao T, Nakamura K, Sasaki T, Takahashi S, Kamada N, Matsubara T, Gonzalez FJ, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Toyoda M, Umezawa A, Nagata K, Matsunaga T, Ohmori S
- Journal Title
  
  DMPK
  
  Volume: 29 Issue: 3 Pages: 237-243
- DOI
  10.2133/dmpk.dmpk-13-rg-104
  10.2133/dmpk.DMPK-13-RG-104
- NAID
  130004463382
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390036, KAKENHI-PROJECT-25460195, KAKENHI-PROJECT-25860120
[Journal Article] Differentiation of monkey embryonic stem cells to hepatocytes by feeder-free dispersion culture and expression analyses of cytochrome P450 enzymes responsible for drug metabolism2013
- Author(s)
  Maruyama J, Matsunaga T, Yamaori S, Sakamoto S, Kamada N, Nakamura K, Kikuchi S, Ohmori S
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 36 Pages: 292-298
- NAID
  130002480763
- Data Source
  KAKENHI-PROJECT-23390036
[Journal Article] Hepatocyte Nuclear Factor 6 Activates the Transcription of <i>CYP3A4</i> in Hepatocyte-like Cells Differentiated from Human Induced Pluripotent Stem Cells2013
- Author(s)
  Sasaki T, Takahashi S, Numata Y, Narita M, Tanaka Y, Kondo Y, Matsunaga T, Ohmori S, Nagata K
- Journal Title
  
  DMPK
  
  Volume: 28 Issue: 3 Pages: 250-259
- DOI
  10.2133/dmpk.dmpk-12-rg-132
  10.2133/dmpk.DMPK-12-RG-132
- NAID
  130004463310
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390028, KAKENHI-PROJECT-23790193
[Journal Article] Differentiation of Monkey Embryonic Stem Cells to Hepatocytes by Feeder-Free Dispersion Culture and Expression Analyses of Cytochrome P450 Enzymes Responsible for Drug Metabolism2013
- Author(s)
  Maruyama J, Matsunaga T, Yamaori S, Sakamoto S, Kamada N, Nakamura K, Kikuchi S, Ohmori S
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 36 Issue: 2 Pages: 292-298
- DOI
  10.1248/bpb.b12-00866
- NAID
  130002480763
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390028
[Journal Article] Clinical Evidence of Pharmacokinetic Changes in Thalidomide Therapy2013
- Author(s)
  Nakamura K, Matsuzawa N, Ohmori S, Ando Y, Yamazaki H, Matsunaga T
- Journal Title
  
  DMPK
  
  Volume: 28 Issue: 1 Pages: 38-43
- DOI
  10.2133/dmpk.dmpk-12-rv-089
  10.2133/dmpk.DMPK-12-RV-089
- NAID
  130004463295
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390028, KAKENHI-PROJECT-23590200
[Journal Article] Differentiation of monkey embryonic stem cells to hepatocytes by feeder-free dispersion culture and expression analyses of cytochrome p450 enzymes responsible for drug metabolism.2013
- Author(s)
  Maruyama J, Matsunaga T, Yamaori S, Sakamoto S, Kamada N, Nakamura K, Kikuchi S, Ohmori S.
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 36(2) Pages: 292-298
- NAID
  130002480763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590133
[Journal Article] An Efficient Method for Differentiation of Human Induced Pluripotent Stem Cells into Hepatocyte-Like Cells Retaining Drug Metabolizing Activity.2013
- Author(s)
  Kondo Y, Iwao T, Nakamura K, Sasaki T, Takahashi S, Kamada N, Matsubara T, Gonzalez FJ, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Toyoda M, Umezawa A, Nagata K, Matsunaga T, Ohmori S.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 0 Pages: 0-0
- NAID
  130004463382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460193
[Journal Article] Clinical evidence of the pharmacokinetics change in thalidomide therapy2013
- Author(s)
  Nakamura K, Matsuzawa N, Ohmori S, Ando Y, Yamazaki H, Matsunaga T
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 28 Pages: 38-43
- NAID
  130004463295
- Data Source
  KAKENHI-PROJECT-23390036
[Journal Article] Hepatocyte nuclear factor 6 activates the transcription of CYP3A4 in hepatocyte-like cells differentiated from human induced pluripotent stem cells2013
- Author(s)
  Sasaki T, Takahashi S, Numata Y, Narita M, Tanaka Y, Kondo Y, Matsunaga T, Ohmori S, Nagata K
- Journal Title
  
  Drug Metabol Pharmacokinet
  
  Volume: 28 Pages: 250-259
- NAID
  130004463310
- Data Source
  KAKENHI-PROJECT-23390036
[Journal Article] Effect of CYP2C19 gene variations on thalidomide treated patients in Japanese.2012
- Author(s)
  Matsuzawa N, Nakamura K, Matsuda M, Ishida F, Ohmori S
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 35(3) Pages: 317-320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590133
[Journal Article] Treatment of a GIST patient with modifieddose of sunitinib by measurement of plasma drug concentrations.2012
- Author(s)
  Hashita T, Katsuyama Y, Nakamura K, Momose Y, Komatsu D, Koide N, Miyagawa S, Nakamura T, Yamamoto K, Ohmori S.
- Journal Title
  
  Oncol Lett.
  
  Volume: 4(3) Pages: 501-504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590133
[Journal Article] Influence of Cytochrome P450 2C19 Gene Variations on Pharmacokinetic Parameters of Thalidomide in Japanese Patients2012
- Author(s)
  Matsuzawa N, Nakamura K, Matsuda M, Ishida F, Ohmori S
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 35 Pages: 317-320
- NAID
  130001872311
- Data Source
  KAKENHI-PROJECT-23390036
[Journal Article] Effects of hypoxia-inducible factor-1α chemical stablizer, CoCl_2 and hypoxia on gene expression of CYP3As in human fetal liver cells2012
- Author(s)
  Suzuki E, Matsunaga T, Aonuma A, Sasaki T, Nagata K, Ohmori S
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390036
[Journal Article] Evaluation of human embryonic stem cell-derived hepatocyte-like cells for detection of CYP1A inducers2012
- Author(s)
  Tsuchiya H, Matsunaga T, Aikawa K, Kamada N, Nakamura K, Ichikawa H, Sasaki K, Ohmori S
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 27 Pages: 598-604
- NAID
  130004933512
- Data Source
  KAKENHI-PROJECT-23390036
[Journal Article] Mechanisms of CYP3A induction by glucocorticoids in human fetal liver cells2012
- Author(s)
  Matsunaga T, Maruyama M, Matsubara T, Nagata K, Yamazoe Y, Ohmori S
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 27 Pages: 653-657
- NAID
  130004933510
- Data Source
  KAKENHI-PROJECT-23390036
[Journal Article] CYP4F2 gene polymorphism as a contributor to warfarin maintenance dose in Japanese subjects.2012
- Author(s)
  Nakamura K, Obayashi K, Araki T, Aomori T, Fujita Y, Okada Y, Kurabayashi M, Hasegawa A, Ohmori S, Nakamura T, Yamamoto K.
- Journal Title
  
  J Clin Pharm Ther
  
  Volume: 37(4) Pages: 481-485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590133
[Journal Article] Lower expression of HNF4α and PGC1α might impair rifampicin-mediated CYP3A4 induction under conditions where PXR is overexpressed in human fetal liver cells.2012
- Author(s)
  Takezawa T, Matsunaga T, Aikawa K, Nakamura K, Ohmori S.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 27(4) Pages: 430-438
- NAID
  130004463268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590133
[Journal Article] Lower expression of HNF4α and PGC1α might impair rifampicin-mediated CYP3A4 induction under conditions where PXR overexpressed in human fetal liver cells.2012
- Author(s)
  Takezawa T, Matsunaga T, Aikawa K, Nakamura K, Ohmori S
- Journal Title
  
  Drug Metabol Pharmacokinet
  
  Volume: 27 Pages: 430-438
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390028
[Journal Article] Evaluation of Human Embryonic Stem Cell-derived Hepatocyte-like Cells for Detection of CYP1A Inducers2012
- Author(s)
  Tsuchiya H, Matsunaga T, Aikawa K, Kamada N, Nakamura K, Ichikawa H, Sasaki K, Ohmori S
- Journal Title
  
  DMPK
  
  Volume: 27 Issue: 6 Pages: 598-604
- DOI
  10.2133/dmpk.dmpk-12-rg-017
  10.2133/dmpk.DMPK-12-RG-017
- NAID
  130004933512
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390028
[Journal Article] Effects of hypoxia-inducible factor-1α chemical stabilizer, CoCl_2 and hypoxia on gene expression of CYP3As in human fetal liver cells.2012
- Author(s)
  Suzuki E, Matsunaga T, Aonuma A, Sasaki T, Nagata K, Ohmori S
- Journal Title
  
  Drug Metabol Pharmacokinet
  
  Volume: 27 Pages: 398-404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390028
[Journal Article] Evaluation of human embryonic stem cell-derived hepatocyte-like cells for detection of CYP1A inducers. Drug Metab Pharmacokinet.2012
- Author(s)
  Tsuchiya H, Matsunaga T, Aikawa K, Kamada N, Nakamura K, Ichikawa H, Sasaki K, Ohmori S.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 27(6) Pages: 598-604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590133
[Journal Article] Mechanisms of CYP3A Induction by Glucocorticoids in Human Fetal Liver Cells2012
- Author(s)
  Matsunaga T, Maruyama M, Matsubara T, Nagata K, Yamazoe Y, Ohmori S
- Journal Title
  
  DMPK
  
  Volume: 27 Issue: 6 Pages: 653-657
- DOI
  10.2133/dmpk.dmpk-12-nt-018
  10.2133/dmpk.DMPK-12-NT-018
- NAID
  130004933510
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390028
[Journal Article] Influence of Cytochrome P450 2C19 Gene Variations on Pharmacokinetic Parameters of Thalidomide in Japanese Patients2012
- Author(s)
  Matsuzawa N, Nakamura K, Matsuda M, Ishida F, Ohmori S
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 35 Pages: 317-320
- NAID
  130001872311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390028
[Journal Article] Lower expression of HNF4α and PGC1α might impair rifampicin-mediated CYP3A4 induction under conditions where PXR overexpressed in human fetal liver cells2012
- Author(s)
  Takezawa T, Matsunaga T, Aikawa K, Nakamura K, Ohmori S
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390036
[Journal Article] ES細胞の肝細胞への分化と薬物動態試験への応用.2010
- Author(s)
  松永民秀,大森栄
- Journal Title
  
  医学のあゆみ
  
  Volume: 232(2) Pages: 447-457
- Data Source
  KAKENHI-PROJECT-22590133
[Journal Article] ES細胞の肝細胞への分化と薬物動態試験への応用2010
- Author(s)
  松永民秀, 大森栄
- Journal Title
  
  医学のあゆみ 232
  
  Pages: 99-104
- Data Source
  KAKENHI-PROJECT-20590142
[Journal Article] CYP3As gene expression and testosterone 6β-hydroxylase activity in human fetal membranes and placenta at full term.2010
- Author(s)
  Maezawa K, Matsunaga T, Takezawa T, Kanai M, Ohira S, Ohmori S
- Journal Title
  
  Biol Pharm Bull 33
  
  Pages: 249-254
- Data Source
  KAKENHI-PROJECT-20590142
[Journal Article] Cytochrome P450 3As Gene Expression and Testosterone 6.BETA.-Hydroxylase Activity in Human Fetal Membranes and Placenta at Full Term2010
- Author(s)
  Maezawa K, Matsunaga T, Takezawa T, Kanai M, Ohira S, Ohmori S
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 33 Issue: 2 Pages: 249-254
- DOI
  10.1248/bpb.33.249
- NAID
  130000156632
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390028
[Journal Article] ES細胞の肝細胞への分化と薬物動態試験への応用2010
- Author(s)
  松永民秀, 大森栄
- Journal Title
  
  医学のあゆみ
  
  Volume: 232 Pages: 99-109
- Data Source
  KAKENHI-PROJECT-22390028
[Journal Article] Role of dexamethasone and oncostatin M on the formation of vacuoles in human fetal liver cells.2009
- Author(s)
  Teramoto T, Matsunaga T, Toba M, Sunazuka T, Omura S, Ohmori S
- Journal Title
  
  Biol Pharm Bull 32
  
  Pages: 209-212
- NAID
  110007042161
- Data Source
  KAKENHI-PROJECT-20590142
[Journal Article] Differentiation of monkey embryonic stem cells into hepatocytes and mRNA expression of cytochrome P450 enzymes responsible for drug metabolism : Comparison of embryoid body formation conditions and matrices.2009
- Author(s)
  Momose Y, Matsunaga T, Murai K, Takezawa T, Ohmori S
- Journal Title
  
  Biol Pharm Bull 32
  
  Pages: 619-626
- NAID
  110007160692
- Data Source
  KAKENHI-PROJECT-20590142
[Journal Article] Formation of large vacuoles induced by cooperative effects of oncostatin M and dexamethasone in human fetal liver cells.2008
- Author(s)
  Matsunaga T, Toba M, Teramoto T, Mizuya M, Aikawa K, Ohmori S
- Journal Title
  
  Med Mol Morphol 41
  
  Pages: 53-58
- NAID
  10024380775
- Data Source
  KAKENHI-PROJECT-20590142
[Journal Article] ヒト胎児肝細胞におけるCYP3A発現変動とES細胞研究2008
- Author(s)
  松永民秀, 大森栄
- Journal Title
  
  Pharma VISION NEWS No.12
  
  Pages: 19-23
- Data Source
  KAKENHI-PROJECT-20590142
[Journal Article] 胎児におけるシトクロムP450の発現:肝臓のCYP3A分子種を中心として2008
- Author(s)
  松永民秀、丸山昌孝、大森栄
- Journal Title
  
  信州医学雑誌 56
  
  Pages: 7-16
- NAID
  130004551686
- Data Source
  KAKENHI-PROJECT-20590142
[Journal Article] Expression of cytochrome P450 and transcription factors during in vitro differentiation of mouse embryonic stem cells into hepatocytes.2008
- Author(s)
  Maezawa K, Miyazato K, Matsunaga T, Momose Y, Imamura T, Johkura K, Sasaki K, Ohmori S
- Journal Title
  
  Drug Metabol Pharmacokin 23
  
  Pages: 188-195
- NAID
  130005024407
- Data Source
  KAKENHI-PROJECT-20590142
[Journal Article] Determination of P-glycoprotein ATPase Activity using Luciferase.2006
- Author(s)
  Matsunaga T, Kose E, Yasuda S, Ise H, Ikeda U, Ohmori S
- Journal Title
  
  Biochem Pharm Bull 29巻
  
  Pages: 560-564
- NAID
  110005602145
- Data Source
  KAKENHI-PROJECT-18590138
[Journal Article] Determination of P-glycoprotein ATPase Activity using Luciferase.2006
- Author(s)
  Matsunaga T, Kose E, Yasuda S, Ise H, Ikeda U, Ohmori S
- Journal Title
  
  Biochem Pharm Bull 29巻
  
  Pages: 560-564
- NAID
  110005602145
- Data Source
  KAKENHI-PROJECT-17659044
[Journal Article] Simple and highly sensitive method for determination of P-glycoprotein ATPase activity using Luciferase.2005
- Author(s)
  Ohmori S et al.
- Journal Title
  
  Drug Metab Rev 37
  
  Pages: 176-176
- Data Source
  KAKENHI-PROJECT-17659044
[Journal Article] Simple and highly sensitive method for determination of P-glycoprotein ATPase activity using Luciferase.2005
- Author(s)
  Ohmori S et al.
- Journal Title
  
  Drug Metab Rev 37
  
  Pages: 176-176
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390047
[Journal Article] Simple and highly sensitive method for determination of P-glycoprotein ATPase activity using Luciferase.2005
- Author(s)
  Ohmori S et al.
- Journal Title
  
  Drug Metab Rev 37
  
  Pages: 176-176
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590109
[Presentation] Characterization of antihypertensive drugs as potent inhibitors of CYP2J22018
- Author(s)
  Yamaori S, Ikemura N, Kobayashi C, Kamijo S, Ohmori S
- Organizer
  22nd North American International Society for the Study of Xenobiotics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08368
[Presentation] ヒト胎児肝細胞における糖質コルチコイドによる硫酸転移酵素SULT1E1の発現誘導2017
- Author(s)
  山折　大、相川香織、上条しのぶ、松永民秀、大森　栄
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県）
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-16K08368
[Presentation] エパルレスタットによるCYP4A11の選択的阻害作用2015
- Author(s)
  山折　大, 荒木規行, 池畑くるみ, 大森　栄, 渡辺和人
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀（東京）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25460167
[Presentation] Potency and mechanism of CYP2J2 inhibition by major phytocannabinoids2015
- Author(s)
  Yamaori S, Nagata Y, Ohmori S, Yamamoto I, Watanabe K
- Organizer
  20th North American ISSX Meeting
- Place of Presentation
  Orlando (USA)
- Year and Date
  2015-10-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460167
[Presentation] ダナゾールのヒトCYP3A活性に対する阻害作用2014
- Author(s)
  山折　大，津田有加，大森　栄，渡辺和人
- Organizer
  医療薬学フォーラム2014／第22回クリニカルファーマシーシンポジウム
- Place of Presentation
  ビッグサイトTFTホール
- Year and Date
  2014-06-29
- Data Source
  KAKENHI-PROJECT-25460167
[Presentation] Evaluation of Luciferin-4A O-demethylase activity as a CYP4A11 marker in human liver and kidney microsomes2014
- Author(s)
  Yamaori S, Shionoiri M, Ohmori S, Watanabe K
- Organizer
  19th North American ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-10-20
- Data Source
  KAKENHI-PROJECT-25460167
[Presentation] ヒト人工多能性幹細胞の肝細胞への分化における変法L-15 培地及び血清の効果2013
- Author(s)
  松永民秀, 近藤祐樹, 荻原留理, 岩尾岳洋, 永田清, 黒瀬光一, 堀川隆司, 丹羽卓朗, 山折大, 大森栄, 中村克徳
- Organizer
  フォーラム2013 : 衛生薬学・環境トキシコロジー
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23390036
[Presentation] Pharmacokinetic function of hepatocyte-like cells differentiated from human iPS cells2013
- Author(s)
  Kondo Y, Iwao T, Ogihara R, Sasaki T, Nagata K, Kurose K, Horikawa T, Niwa T, Yamaori S, Ohmori S, Nakamura K Matsunaga T
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390036
[Presentation] Guiding the differentiation of human induced pluripotent stem cells into definitive endoderm using a combination of small-molecule compounds2013
- Author(s)
  Ogihara R, Kondo Y, Iwao T, Yamaori S, Ohmori S, Nakamura K, Matsunaga T
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390036
[Presentation] ヒト人工多能性幹細胞から分化させた肝細胞様細胞による薬物代謝酵素の酵素誘導評価2012
- Author(s)
  中村克徳, 近藤祐樹, 杉山留理, 相川香織, 松永民秀, 大森栄
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23390036
[Presentation] ヒト人工多能性幹細胞から分化させた肝細胞様細胞による薬物代謝酵素の酵素誘導評価2012
- Author(s)
  中村克徳、近藤祐樹、杉山留理、相川香織、松永民秀、大森栄
- Organizer
  日本薬学会第132年回
- Place of Presentation
  札幌
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-22590133
[Presentation] ヒト人工多能性幹細胞から分化させた肝細胞による薬物代謝酵素の酵素誘導評価2012
- Author(s)
  中村克徳, 近藤祐樹, 杉山留理, 相川香織, 松永民秀, 大森栄
- Organizer
  日本薬学会第132 年会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-22590133
[Presentation] Small Molecule Compounds Enhance Differentiation to Hepatocytes from induced Pluripotent Stem Cells.2012
- Author(s)
  Yuki Kondo, Takahiro Iwao, Sachimi Yoshihashi, Kayo Mimori, Ruri Sugiyama, Takamitsu Sasaki, Kiyoshi Nagata, Kouichi Kurose, Takuro Niwa, Satoshi Yamaori, Shigeru Ohmori, Katsunori Nakamura, Tamihide Matsunaga
- Organizer
  第27回日本薬物動態学会年会
- Place of Presentation
  船堀
- Data Source
  KAKENHI-PROJECT-22590133
[Presentation] Small molecule compounds enhance differentiation to hepatocytes from human induced pluripotent stem cells(低分子化合物はヒト人工多能性幹細胞から肝細胞への分化を促進する).2012
- Author(s)
  近藤祐樹,岩尾岳洋,吉橋幸美,三森佳代,杉山留理,佐々木崇光,永田清,黒瀬光一,丹羽卓朗,山折大,大森栄,中村克徳,松永民秀
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22390028
[Presentation] 低分子化合物はヒト人工多能性幹細胞から肝細胞への分化を促進する2012
- Author(s)
  近藤祐樹, 岩尾岳洋, 吉橋幸美, 三森佳代, 杉山留理, 佐々木崇光, 永田清, 黒瀬光一, 丹羽卓朗, 山折大, 大森栄, 中村克徳, 松永民秀
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390036
[Presentation] 妊婦に対するお薬相談妊娠と薬情報センター拠点病院に参加して2012
- Author(s)
  竹田晶子, 村田稔弥, 鳥羽美恵, 丸山順也, 中村克徳, 百瀬泰行, 金井誠, 大森栄.
- Organizer
  日本薬学会第132 年会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-22590133
[Presentation] ヒト人工多能性幹細胞から分化させた肝細胞様細胞による薬物代謝酵素の酵素誘導評価2012
- Author(s)
  中村克徳、近藤祐樹、杉山留理、相川香織、松永民秀、大森栄
- Organizer
  日本薬学会第132年回
- Place of Presentation
  札幌
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-22390028
[Presentation] ヒトiPS細胞の肝細胞様細胞への分化と薬物代謝酵素の発現2011
- Author(s)
  松永民秀, 近藤祐樹, 岩尾岳洋, 大森栄
- Organizer
  日本法中毒学会第30年会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-23390036
[Presentation] ヒト人工多能性幹細胞の肝細胞への分化と薬物代謝酵素の発現解析2011
- Author(s)
  近藤祐樹, 鎌田昇, 坂本栄, 松永民秀, 大森栄
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-22390028
[Presentation] 大型類人猿の肝薬物代謝酵素の特性について2011
- Author(s)
  星山望,中村克徳,松永民秀,大森栄
- Organizer
  日本薬学会第131 年会
- Place of Presentation
  静岡市
- Data Source
  KAKENHI-PROJECT-22590133
[Presentation] ヒト人工多能性幹細胞の肝細胞への分化と薬物代謝酵素の発現解析2011
- Author(s)
  近藤祐樹,鎌田昇,坂本栄,松永民秀,大森栄
- Organizer
  日本薬学会第131 年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-22390028
[Presentation] ヒト人工多能性幹細胞からの肝細胞への効率的な分化方法の検討2011
- Author(s)
  近藤祐樹, 岩尾岳洋, 三森佳代, 吉橋幸美, 大森栄, 松永民秀
- Organizer
  第57回日本薬学会東海支部総会・大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23390036
[Presentation] 正常ヒト胎児肝細胞のCYP3A発現に及ぼす擬似低酸素誘導化合物デフェロキサミンの影響2011
- Author(s)
  青沼安希子, 鈴木英二, 中村克徳, 松永民秀, 大森栄
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-20590142
[Presentation] 正常ヒト胎児肝細胞の CYP3A 発現に及ぼす擬似低酸素誘導化合物デフェロキサミンの影響2011
- Author(s)
  青沼安希子,鈴木英二,中村克徳,松永民秀,大森栄
- Organizer
  日本薬学会第131 年会
- Place of Presentation
  静岡市
- Data Source
  KAKENHI-PROJECT-22590133
[Presentation] ヒト iPS 細胞の肝細胞様細胞への分化と薬物代謝酵素の発現2011
- Author(s)
  松永民秀,近藤祐樹,岩尾岳洋,大森栄
- Organizer
  日本法中毒学会第30 年会
- Place of Presentation
  長崎
- Year and Date
  2011-06-11
- Data Source
  KAKENHI-PROJECT-22390028
[Presentation] 正常ヒト胎児肝細胞のCYP3A 発現に及ぼす擬似低酸素誘導化合物デフェロキサミンの影響2011
- Author(s)
  青沼安希子,鈴木英二,中村克徳,松永民秀,大森栄
- Organizer
  日本薬学会第131 年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-22390028
[Presentation] 大型類人猿の肝薬物代謝酵素の特性について2011
- Author(s)
  星山望、中村克徳、松永民秀、大森栄
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-20590142
[Presentation] 遺伝薬理学を用いた個別化医療の推進に関する研究.2011
- Author(s)
  中村克徳, 大森栄
- Organizer
  2011年度中部乳酸菌研究会
- Place of Presentation
  新潟市
- Data Source
  KAKENHI-PROJECT-22590133
[Presentation] ヒト人工多能性幹細胞からの肝細胞への効率的な分化方法の検討.2011
- Author(s)
  近藤祐樹,岩尾岳洋,三森佳代,吉橋幸美,大森栄,松永民秀
- Organizer
  第57回日本薬学会東海支部総会・大会
- Place of Presentation
  名古屋
- Year and Date
  2011-07-09
- Data Source
  KAKENHI-PROJECT-22390028
[Presentation] ヒト iPS 細胞の肝細胞様細胞への分化と薬物代謝酵素の発現2011
- Author(s)
  松永民秀, 近藤祐樹, 岩尾岳洋, 大森栄
- Organizer
  日本法中毒学会第30年会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-23390036
[Presentation] ヒトES由来肝細胞のCYPIA誘導剤検出系としての評価2010
- Author(s)
  土屋広行,松永民秀,中村克徳,市川比奈子,佐々木克典,大森栄
- Organizer
  第25回日本薬物動態学会年会
- Place of Presentation
  大宮市
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-22590133
[Presentation] ビタミン K 代謝の個人差と血栓塞栓症発症リスク因子の解析.2010
- Author(s)
  中村克徳, 大森栄
- Organizer
  2010年度中部乳酸菌研究会
- Place of Presentation
  松本市
- Data Source
  KAKENHI-PROJECT-22590133
[Presentation] サルES細胞の肝細胞への分化と薬物動態研究2010
- Author(s)
  丸山順也,坂本栄,松永民秀,中村克徳,菊池伸次,大森栄
- Organizer
  第25回日本薬物動態学会年会
- Place of Presentation
  大宮市
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-22590133
[Presentation] ヒト卵膜および胎盤におけるCYP3A遺伝子の発現とTestosterone 6β-水酸化活性2010
- Author(s)
  前澤佳代子, 松永民秀, 竹澤崇, 金井誠, 大平哲史, 木津純子, 大森栄
- Organizer
  医療薬学フォーラム2010/第18回クリニカルファーマシーシンポジウム
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-20590142
[Presentation] 腎細胞癌患者におけるスニチニブ血中濃度と副作用の相関性.2010
- Author(s)
  坡下真大,勝山義彦,松澤直樹,井上博夫,栗崎功己,田辺智明,中村克徳,百瀬泰行,西沢理,大森栄.
- Organizer
  第20回日本医療薬学会年会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-22590133
[Presentation] CYP2C19 遺伝子多型によるサリドマイド体内動態変化に関する研究.2010
- Author(s)
  松澤直樹,中村克徳,百瀬泰行,松永民秀,松田正之,大森栄
- Organizer
  第37回日本トキシコロジー学会学術年会
- Place of Presentation
  宜野湾市
- Data Source
  KAKENHI-PROJECT-22590133
[Presentation] サルES細胞の肝細胞への分化と薬物動態研究2010
- Author(s)
  丸山順也, 坂本栄, 松永民秀, 中村克徳, 菊池伸次, 大森栄
- Organizer
  第25回日本薬物動態学会年会
- Place of Presentation
  大宮市
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-22390028
[Presentation] サル胚性幹細胞の肝細胞への分化と薬物代謝に関与するシトクロムP450のmRNA発現2010
- Author(s)
  松永民秀, 百瀬泰行, 大森栄
- Organizer
  日本薬学会第130年会シンポジウム
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590142
[Presentation] 正常ヒト胎児肝細胞のCYP3A発現に対する擬似低酸素誘導化合物の効果2010
- Author(s)
  青沼安希子, 鈴木英二, 中村克徳, 松永民秀, 大森栄
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2010(第20回日本病院薬剤師会東海ブロック学術大会・平成22年度日本薬学東海支部例会)
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-20590142
[Presentation] 遺伝子多型を考慮したサリドマイド適正使用の試み. シンポジウム 20 病院薬剤師による薬物治療個別化への遺伝子情報の活用2010
- Author(s)
  中村克徳,松澤直樹,大森栄
- Organizer
  第20回日本医療薬学会年会,シンポジスト
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-22590133
[Presentation] ヒト ES 由来肝細胞の CYP1A 誘導剤検出系としての評価(EVALUATION OF HUMAN EMBRYONIC STEM CELLS- DERIVEDHEPATOCYTES TO DETECTION SYSTEM OF CYPIA INDUCER).2010
- Author(s)
  土屋広行, 松永民秀, 中村克徳, 市川比奈子, 佐々木克典, 大森栄
- Organizer
  第25回日本薬物動態学会年会
- Place of Presentation
  大宮市
- Data Source
  KAKENHI-PROJECT-22590133
[Presentation] ヒトES由来肝細胞のCYP1A誘導剤検出系としての評価2010
- Author(s)
  土屋広行, 松永民秀, 中村克徳, 市川比奈子, 佐々木克典, 大森栄
- Organizer
  第25回日本薬物動態学会年会
- Place of Presentation
  大宮市
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-22390028
[Presentation] HPLC-UV 検出器を用いた Sunitinib および活性代謝物N-desethylsunitinib 血中濃度測定法の確立と臨床応用.2010
- Author(s)
  勝山善彦,坡下真大,松澤直樹,中村克徳,西澤理,大森栄.
- Organizer
  第27回日本 TDM 学会学術大会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-22590133
[Presentation] 正常ヒト胎児肝細胞の CYP3A 発現に対する擬似低酸素誘導化合物の効果.2010
- Author(s)
  青沼安希子,鈴木英二,中村克徳,松永民秀,大森栄.
- Organizer
  第20回日本病院薬剤師会東海ブロック学術大会・平成22年度日本薬学東海支部例会
- Place of Presentation
  静岡市
- Year and Date
  2010-11-28
- Data Source
  KAKENHI-PROJECT-22590133
[Presentation] サル ES 細胞の肝細胞への分化と薬物動態研究 (DIFFERENTIATION OF MONKEY EMBRYONIC STEM CELLS TO HEPATOCYTES AND PHARMACOKINETIC STUDIES).2010
- Author(s)
  丸山順也, 坂本栄, 松永民秀, 中村克徳, 菊池伸次, 大森栄
- Organizer
  第25回日本薬物動態学会年会
- Place of Presentation
  大宮市
- Data Source
  KAKENHI-PROJECT-22590133
[Presentation] Expression of cytochrome P450 and transcription factors during differentiation of mouse ES cells into hepatocytes2009
- Author(s)
  Matsunaga T, Maezawa K, Miyazato K, Momose Y, Imamura T, Johkura K, Sasaki K, Ohmori S
- Organizer
  16th International Conference on Cytochrome P450
- Place of Presentation
  Nago, Okinawa, Japan
- Data Source
  KAKENHI-PROJECT-20590142
[Presentation] リファンピシンによるヒト胎児肝細胞CTP3As誘導に関する制御機構の解明2008
- Author(s)
  松永民秀, 大森栄
- Organizer
  平成20年度中部乳酸菌研究会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-20590142
[Presentation] ヒト胚性幹細胞の肝細胞への分化と動態研究2008
- Author(s)
  松永民秀, 大森栄
- Organizer
  第23回日本薬物動態学会年会シンポジウム
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-20590142
[Presentation] 霊長類肝におけるCYP3A分子種の発現2008
- Author(s)
  土屋広行, 丸山順也, 松永民秀, 大森栄
- Organizer
  新手法を用いた薬物代謝酵素活性の個人差研究会
- Place of Presentation
  福島県安達郡大玉村
- Data Source
  KAKENHI-PROJECT-20590142

1. MATSUNAGA Tamihide (40209581)

# of Collaborated Projects: 10 results

# of Collaborated Products: 72 results
2. KITADA Mitsukazu (90110345)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. ISHII Itsuko (00202929)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. NAKAMURA Katsunori (20361363)

# of Collaborated Projects: 3 results

# of Collaborated Products: 36 results
5. YAMAORI Satoshi (40360218)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
6. 仲佐啓詳 (60260478)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. NARIMATSU Shizuo (20113037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KIMURA Kazunori (00423848)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ANDO Yuichi (10360083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SATOH Tetsuo (60092061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HOSOKAWA Masakiyo (70181500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SASAKI Katsunori (30170666)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KITAGAWA Haruo (60009157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. IGARASHI Takashi (60104692)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. UENO Koichi (60125903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 金久保好男 (30004873)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 力久忠昭 (70012622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 永田清 (80189133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
19. 吉成浩一 (60343399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 佐々木崇光

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. 山崎浩史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 渡辺和人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 岩尾岳洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHMORI Shigeru 大森 栄

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Elucidation of mechanisms underlying different glucocorticoid responses of drug-metabolizing enzymes, SULT1E1 and CYP3A7, in human fetal liver cellsPrincipal Investigator

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Differentiation ofhuman iPS cells into hepatocytes and bile duct epithelial cells and application to drug development studyPrincipal Investigator

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サル胚性幹細胞の肝細胞への分化と胎児薬物動態予測モデルの構築Principal Investigator

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Basic Study for Regenerative Medicine : Differentiate of Embryonic Stem Cells to Hepatocytes and Expressions of Cytochrome P450 in the Differentiating CellsPrincipal Investigator

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薬物間相互作用の予測に関する研究:漢方薬との相互作用を中心としてPrincipal Investigator

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OHMORI Shigeru 大森栄