KUBO Nobuo 久保伸夫

Researcher Number	70186435
External Links
Affiliation (based on the past Project Information) *help	1999 – 2001: 関西医科大学, 医学部, 助教授 1992 – 1997: 関西医科大学, 医学部, 講師 1995: Kansai Medical University, Associate Professor, 医学部, 助教授 1993: Kansai Medical University, Assistant Professor, 耳鼻咽喉科, 講師 1992: 関西医科大学, 医学部・耳鼻咽喉科, 講師
Review Section/Research Field	Principal Investigator Otorhinolaryngology Except Principal Investigator Otorhinolaryngology
Keywords	Principal Investigator 一酸化窒素 / ATP / NO / 室内汚染 / 慢性副鼻腔炎 / アレルギー性鼻炎 / 血管内皮細胞 / exhaled NO / indoor pollution / nitric dioxide … More / nitric oxide / ガス調理器具 / 気管支喘息 / 喫煙 / カズ調理器具 / 室内空気汚染 / 呼気NO / 二酸化窒素 / Nasal allergy / Intracellular Ca^2+ Concentration / Histamine / Nasal Mucosal / Endothelial Cells / 虚血-再環流障害 / 活性酸素 / 鼻茸症 / 鼻過敏症 / 細胞内カルシウム濃度 / ヒスタミン / 鼻粘膜 / 鼻粘膜血管内皮細胞 / 窒素酸化物 / 呼気ガス … More Except Principal Investigator PAF / 細胞内カルシウム濃度 / nasal mucosa / intracellular calcium level / leukotoluene / vascular endothelial cells / histamine / nitric oxide / ロイコトリエン / 細胞内カルシウム / 培養ヒト鼻粘膜血管内皮細胞 / 鼻粘膜 / ロイコトルエン / ヒスタミン / 一酸化窒素 / 血管内皮細胞 / otitis media with effusion / middle ear, / gas exchange, / 中耳腔粘膜 / 中耳換気 / 酸素センサー / 経粘膜的換気 / 中耳腔圧調節 / 滲出性中耳炎 / 中耳腔 / ガス交換 / Perilymphatic fistula / Inner ear biology / Immunopathology / Endolymphatic sac / Endolymphatic hydrops / Meniere's disease / 骨髄移植 / 対宿主移植片病 / 自己免疫病 / 内リンパ管破壊 / メニエール氏病 / 免疫学 / 外リンパ瘻 / 内耳生化学 / 免疫病理学 / 内リンパ嚢 / 内リンパ水腫 / メニエール病 / intracellular Cl- concentration16FA06 : fura-2 / intracellular Ca^<2+> concentration / spiral ganglion cells / vestibular hair cells / Cochlear hair cells / 細胞収縮 / 細胞内遊離Cl^-濃度 / 細胞内遊離Ca^<2+>濃度 / 遠心性神経伝達物質 / 蝸牛内有毛細胞 / 前庭器有毛細胞 / gultamate / ATP / Ach / 細胞内Ca^<2+>濃度 / 蝸牛有毛細胞 / 画像解析法 / 細胞内クロライド濃度 / ラセン神経節細胞 / 前庭有毛細胞 / 蝸牛内・外有毛細胞 Less

Intracellular Ca2+ mobilization and measurements of nitric oxide synthesis on cultured nasal microvascular endothelial cells
- Principal Investigator
  
  TSUJI Hiroyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kansai Medical University
Alteration of exhaled NO by domestic Nox pollutionPrincipal Investigator
- Principal Investigator
  
  KUBO Nobuo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  KANSAI MEDICAL UNIVERSITY
鼻過敏症の発症における血管内皮細胞由来一酸化窒素(NO)障害の関与-呼気ガス中とヒト鼻粘膜由来血管内皮培養細胞のNO産生能測定-Principal Investigator
- Principal Investigator
  
  久保伸夫
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kansai Medical University
Basic research for the transmucosal pressure regulation in the middle ear cavity
- Principal Investigator
  
  TADA Naoki, 木下卓也
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  KANSAI MEDICAL UNIVERSITY
Contribution of the Ischemic-Reperfusion Mechanism to Nasal Hyper SensitivityPrincipal Investigator
- Principal Investigator
  
  KUBO Nobuo
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kansai Medical University
Observations of intracellular Ca^<2+> and Cl-concentrations in inner ear isolated cells
- Principal Investigator
  
  YAMASHITA Toshio
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  KANSAI MEDICAL UNIVERSITY
IMMUNOLOGICAL ROLE OF ENDOLYMPHATIC SAC IN THE OCCURRENCE OF ENDOLYMPHATIC HYDROPS AND RELATION TO THE PERILYMPHATIC FISTULA
- Principal Investigator
  
  TOMODA Koichi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  KANSAI MEDICAL UNIVERSITY

All 2008 2007 2003 2002 2001 1999 1997 1996

All Journal Article Presentation

[Journal Article] Induction of inducible nitric oxide synthase and apoptosis by LPS and TNF-α in nasal microvascular endothelial cells2008
- Author(s)
  Arai S, Harada N, Kubo N, Shen J, Nakamura A, Ikeda H, Tsuji H, Yamashita T.
- Journal Title
  
  Acta Oto-Laryngologica 128
  
  Pages: 78-85
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12671689
[Journal Article] Induction of inducible nitric oxide synthase and apoptosis by LPS and TNF-α in nasal microvascular endothelial cells2008
- Author(s)
  S Arai, N Harada, N Kubo, J Shen
- Journal Title
  
  Acta Oto-laryngologica 128
  
  Pages: 78-85
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12671689
[Journal Article] Physiological and pathological significance of nitric oxide and carbon monoxide in exhalation and their origin2007
- Author(s)
  N.Kubo, K.Yoshinaga
- Journal Title
  
  Clinical and Experimental Allergy Reviews 7
  
  Pages: 27-31
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12671689
[Journal Article] Physiological and pathological significance of nitric oxide and carbon monoxide in exhalation and their origin2007
- Author(s)
  Kubo N, Yoshinaga K
- Journal Title
  
  Clinical and Experimental Allergy Reviews 7
  
  Pages: 27-31
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12671689
[Journal Article] Histamine-induced Calcium Released from Cultured Human Mucosal Microvascular Endothelial Cells from Nasal Inferior Turbinate1997
- Author(s)
  H.Ikeda, N.Kubo, A.Nakamura, N,Harada, M.Minamino, T.Yamashita
- Journal Title
  
  Acta Oto-laryngologica 117
  
  Pages: 864-870
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12671689
[Journal Article] Histamine-induced Calcium Released from Cultured Human Mucosal Microvascular Endothelial Cells from Nasal Inferior Turbinate1997
- Author(s)
  Ikeda H, Kubo N, Nakamura A, Harada N, Minamino N, Yamashita T.
- Journal Title
  
  Acta Oto-Laryngologica 117
  
  Pages: 864-870
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12671689
[Journal Article] Intracellular Ca2+ Mobilization in Cultured Human Mucosal Microvascular Endothelial Cells from the Nasal Inferior Turbinate1996
- Author(s)
  Ikeda H, Kubo N, Nakamura A, Harada N, Yamashita T.
- Journal Title
  
  ORL 58
  
  Pages: 320-325
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12671689
[Journal Article] Intracellular Ca2+ Mobilization in Cultured Human Mucosal Microvascular Endothelial Cells from the Nasal Inferior Turbinate1996
- Author(s)
  H.Ikeda, N.Kubo, A.Nakamura, N.Harada, T.Yamashita
- Journal Title
  
  ORL 58
  
  Pages: 320-325
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12671689
[Presentation] LPS, TNF-α刺激によるヒト鼻粘膜微小血管内皮細胞におけるiNOS発現とアポートシス誘導2003
- Author(s)
  新井昇治, 中村晶彦, 久保伸夫, 山下敏夫, 池田浩己, 原田成信
- Organizer
  第42回日本鼻科学会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12671689
[Presentation] Induction of Inducible Nitric Oxide Synthase and Apoptosis by Lps and Tnf-α in Nasal Microvascular Endthelial Cells2002
- Author(s)
  S.Arai, N.Harada, A.Nakamura, S.Kakimoto, H.Ikeda, N.Kubo, T.Yamashita
- Organizer
  25^<th> ARO Midwinter Meeting
- Place of Presentation
  Florida, USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12671689
[Presentation] Induction of Inducible Nitric Oxide Synthase and Apoptosis by Lps and Tnf-α in Nasal Microvascular Endothelial Cells2002
- Author(s)
  Arai S, Harada N, Nakamura A, Kakimoto S, Ikeda H, Kubo N, Yamashita T
- Organizer
  25th ARO Midwinter Meeting
- Place of Presentation
  Florida, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12671689
[Presentation] NO production in upper and lower airway2001
- Author(s)
  N.Kubo, K.Yoshinaga
- Organizer
  3th International Symposium of Basic Study to Bronchial Asthma and Allergic Rhinitis
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12671689
[Presentation] NO production in upper and lower airway2001
- Author(s)
  Kubo N, Yoshinaga K
- Organizer
  3^<th> International Symposium of Basic Study to Bronchial Asthma and Allergic Rhinitis
- Place of Presentation
  Tokyo Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12671689
[Presentation] Origin of nitric oxide in exhalation and its physiological and pathological alterations1999
- Author(s)
  Nobuo Kubo
- Organizer
  4^<th> New Topics of Clinical Immunology & allergy
- Place of Presentation
  Osaka Japan
- Year and Date
  1999-11-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12671689

1. NAKAMURA Akihiko (90180356)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. KITAJILI Masanori (60161478)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. TADA Naoki (00257932)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. IKEDA Hiroki (90288803)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
5. YAMASHITA Toshio (10077654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. IWAI Hiroshi (10232638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TOMODA Koichi (50164041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KANEKO Akihiro (00247909)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MINAMI Toyohiko (10239311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YOSHINAGA Kazuhito (20309256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TSUJI Hiroyuki (00155368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 天野一 (30159462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 木下卓也 (50177888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KUBO Nobuo 久保 伸夫

Research Projects

Research Products

Co-Researchers

Intracellular Ca2+ mobilization and measurements of nitric oxide synthesis on cultured nasal microvascular endothelial cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Alteration of exhaled NO by domestic Nox pollutionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

鼻過敏症の発症における血管内皮細胞由来一酸化窒素(NO)障害の関与-呼気ガス中とヒト鼻粘膜由来血管内皮培養細胞のNO産生能測定-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic research for the transmucosal pressure regulation in the middle ear cavity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Contribution of the Ischemic-Reperfusion Mechanism to Nasal Hyper SensitivityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Observations of intracellular Ca^<2+> and Cl-concentrations in inner ear isolated cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

IMMUNOLOGICAL ROLE OF ENDOLYMPHATIC SAC IN THE OCCURRENCE OF ENDOLYMPHATIC HYDROPS AND RELATION TO THE PERILYMPHATIC FISTULA

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Induction of inducible nitric oxide synthase and apoptosis by LPS and TNF-α in nasal microvascular endothelial cells2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Induction of inducible nitric oxide synthase and apoptosis by LPS and TNF-α in nasal microvascular endothelial cells2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Physiological and pathological significance of nitric oxide and carbon monoxide in exhalation and their origin2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Physiological and pathological significance of nitric oxide and carbon monoxide in exhalation and their origin2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Histamine-induced Calcium Released from Cultured Human Mucosal Microvascular Endothelial Cells from Nasal Inferior Turbinate1997

Author(s)

Journal Title

Description

Data Source

[Journal Article] Histamine-induced Calcium Released from Cultured Human Mucosal Microvascular Endothelial Cells from Nasal Inferior Turbinate1997

Author(s)

Journal Title

Description

Data Source

[Journal Article] Intracellular Ca2+ Mobilization in Cultured Human Mucosal Microvascular Endothelial Cells from the Nasal Inferior Turbinate1996

Author(s)

Journal Title

Description

KUBO Nobuo 久保伸夫