SAKIHAMA Toshiko 先浜俊子

… Alternative Names

先浜俊子サキハマトシコ

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Researcher Number	70187061
Affiliation (based on the past Project Information) *help	2012: 東京大学, 先端科学技術研究センター, 特任准教授 2007 – 2008: 東京大学, 先端科学技術研究センター, 特任准教授 2007: The University of Tokyo, Research Center for AdvanoedScience and Technology, Specially Appointed Associate Professor 2006: 東京大学, 先端科学技術研究センター, 産学官連携研究員(特任助教授) 2004 – 2005: 東京大学, 先端科学技術研究センター, 科学技術振興特任教員(特任助教授) 2004: 東京大学, 先端科学技術研究センター, 科学技術振興特任教員 1991: 山梨医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Functional biochemistry Except Principal Investigator Living organism molecular science / Experimental pathology
Keywords	Principal Investigator 蛋白質相互作用 / 膜蛋白質 / バイオテクノロジー / 免疫学 / 免疫生化学 / モノクローナル抗体 / 蛋白質発現 / バキュロウイルス Except Principal Investigator GPCR / 核内受容体 … More / プロテオミクス / ラフト / FRET / γセクレターゼ / モノクローナル抗体 / RNAプロセッシング / 細胞周期 / 複合体解析 / cardiovascular disease / nuclear receptor / targeted nroteomics / magnetic beads / proteomics / monoclonal antibody / 血清マーカー / GPCR複合体 / WTAP / 心血管疾患 / Gタンパク質共役型受容体 / 抗体磁気ビーズ / モノクロナール抗体 / peptide transporter / nicastrin / lipid raft / γ-secretase / membrane protein / baculovirus / アルツハイマー / スタチン / HNF4α / 転写複合体 / 磁性ビーズ / ペプチドトランスポーター / ニカストリン / 脂質ラフト / 膜タンパク質 / バキュロウイルス / 核タンパク質 / 軟X線顕微鏡 / 軟Ｘ線顕微鏡 / 生体イメージング / ヒストン修飾 / 核微細構造 / クロマチン修飾 / 核小体 / 核スペックル / 転写調節 / スプライシング / 自己免疫 / IgG遺伝子 / サイトカイン Less

Dynamic Proteomics of Transcriptional and Nuclear Architecture
- Principal Investigator
  
  HAMAKUBO Takao
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Living organism molecular science
- Research Institution
  The University of Tokyo
Analysis of interaction of membrane proteins on immune cells bybaculoviral displayPrincipal Investigator
- Principal Investigator
  
  SAKIHAMA Toshiko
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokyo
The targetedproteomics for membrane protein and nuclear protein
- Principal Investigator
  
  HAMAKUBO Takao
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  The University of Tokyo
バキユロウイルスデイスプレイ法を用いた膜蛋白質相互作用の解析と抗体作成への応用Principal Investigator
- Principal Investigator
  
  先浜俊子
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokyo
Analysis of membrane protein complex using baculoviral display
- Principal Investigator
  
  HAMAKUBO Takao
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  The University of Tokyo
サイトカインを誘導するマウス自己抗体IgG遺伝子の構造解析
- Principal Investigator
  
  田坂捷雄
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  山梨医科大学

All 2011 2008 2007 2005

All Journal Article Presentation

[Journal Article] A novel screening system for claudin binder using baculoviral display.2011
- Author(s)
  Kakutani H, Takahashi A, Kondoh M, Saito Y, Yamaura T, Sakihama T, Hamakubo T, Yagi K.
- Journal Title
  
  PLoS One.
  
  Volume: Febl4;6(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20221010
[Journal Article] A method of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells2011
- Author(s)
  Iwanari H, Nakada-Nakura Y, Kusano-Arai O, Suzuki N, Kodama T, Sakihama T, Hamakubo T
- Journal Title
  
  Journal of Immunological Method
  
  Volume: in press(掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20221010
[Journal Article] Functional reconstitution of G protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system.2008
- Author(s)
  Sakihama T., Masuda K., Sato T., Doi T., Kodama T., Hamakubo T.
- Journal Title
  
  Journal of Biotechnol. (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310142
[Journal Article] A simple detection method forlow-affinity membrane proteininteractions by baculoviral display2008
- Author(s)
  Toshiko Sakihama, Takato Sato,Hiroko Iwanari, Toshio Kitamura, ShimonSakaguchi, Tatsuhiko Kodama, TakaoHamakubo
- Journal Title
  
  PLoS ONE 3,e4024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18570120
[Journal Article] Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system2008
- Author(s)
  Sakihama T, Masuda K, Sato T, Doi T, Kodama T, Hamakubo T.
- Journal Title
  
  J Biotechnol 135(1)
  
  Pages: 28-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20221010
[Journal Article] Functional reconstitution of G protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system2008
- Author(s)
  Toshiko Sakihama
- Journal Title
  
  Journal of Biotechnology (印刷中)掲載確定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18570120
[Journal Article] A simple detection method for low-affinity membrane protein interactions by baculoviral display2008
- Author(s)
  Toshiko Sakihama
- Journal Title
  
  PLoS ONE 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18570120
[Journal Article] Functional reconstitution of G protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system2008
- Author(s)
  Sakihama T., Masuda K., Sato T., Doi T., Kodama T., Hamakubo T.
- Journal Title
  
  Journal of Biotechnol (印刷中)(掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310142
[Journal Article] Functionalreconstitusion of G-protein-coupledreceptor-mediated adenylyl cyclaseactivation by a baculoviral co-displaysystem2008
- Author(s)
  Toshiko Sakihama, Kazuyuki Masuda,Takato Sato, Takefumi Doi, Tatsuhiko Kodama, Takao Hamakubo
- Journal Title
  
  Journal of Biotechnology 135
  
  Pages: 28-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18570120
[Journal Article] Functional reconstitution of G protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system2008
- Author(s)
  Toshiko Sakihama
- Journal Title
  
  Journal of Biotechnology 135
  
  Pages: 28-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18570120
[Journal Article] Viral envelope protein gp64 transgenic mouse facilitates the generation of monoclonal antibodies against exogenous membrane proteins displayed on baculovirus.2007
- Author(s)
  Saitoh R, Ohtomo T, Yamada Y, Kamada N, Nezu JI, Kimura N, Funahashi SI, Furugaki K, Yoshino T, Kawase Y, Kato A, Ueda O, Jishage KI, Suzuki M, Fukuda R, Arai M, Iwanari H, Takahashi K, Sakihama T, Ohizumi I, Kodama T, Tsuchiya M, Hamakubo T.
- Journal Title
  
  J Immunol Methods. Mar:7
- Data Source
  KAKENHI-PROJECT-18310142
[Journal Article] Functional reconstitution of G protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system2007
- Author(s)
  Sakihama T., Masuda K., Sato T., Doi T., Kodama T., Hamakubo T.
- Journal Title
  
  J Biotechnol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18310142
[Journal Article] Decay time shortening of fluorescence from donor-acceptor pair proteins using ultrafast time-resolved fluorescence resonance energy transfer spectroscopy.2007
- Author(s)
  Baba M, Suzuki M, Ganeev RA, Kuroda H, Ozaki T, Hamakubo T, Masuda K, Hayashi M, Sakihama T, Kodama T, Kozasa T.
- Journal Title
  
  Journal of Luminescence 127
  
  Pages: 355-361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310142
[Journal Article] Viral envelope protein gp64 transgenic mouse facilitates the generation of monoclonal antibodies against exogenous membrane proteins displayed on baculovirus2007
- Author(s)
  Saitoh R, Ohtomo T. Yamada Y, Kamada N, Nezu J. Kimura N, Funahashi S, Furugaki K, Yoshino T, Kawase Y, Kato A, Ueda O, jishage K, Suzuki M, Fukuda R, Arai M, Iwanari H, Takahashi K, Sakihama T, Ohizumi I, Kodama T, Tsuchita M, Hamakubo T.
- Journal Title
  
  J Immunol Methods Apr30;322(1-2)
  
  Pages: 104-117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18310142
[Journal Article] Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.2005
- Author(s)
  Tachibana M, Ueda J, Fukuda M, Takeda N, Ohta T, Iwanari H, Sakihama T, Kodama T, Hamakubo T, Shinkai Y.
- Journal Title
  
  Genes Dev. April 1;19
  
  Pages: 815-826
- Data Source
  KAKENHI-PROJECT-16310147
[Journal Article] Histone methyltransferases G9a and GLP form heteromeric complexex and are both crucial for methylation of euchromatin at He-K9.2005
- Author(s)
  Tachibana M, Ueda J, Fukuda M, TakedaN, OhtaT, IwanariH, Sakihama T, Kodama T, Hamakubo T.
- Journal Title
  
  Genes Dev. Apr 1;19(7)
  
  Pages: 815-826
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16310147
[Journal Article] Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.2005
- Author(s)
  Tachibana M, Ueda J, Fukuda M, Takeda N, Ohta T, Iwanari H, Sakihama T, Kodama T, Hamakubo T, Shinkai Y.
- Journal Title
  
  Genes Dev. Apr 1;19(7)
  
  Pages: 815-826
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16310147
[Presentation] Baculovirus Display系を用いた膜蛋白質相互作用検出法とその応用2007
- Author(s)
  先浜俊子、佐藤敬人、北村俊雄、児玉龍彦、浜窪隆雄
- Organizer
  第30回日本分子生物学会第80回日本生化学会合同大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18310142
[Presentation] Baculovirus display系を用いた膜蛋白質問相互作用検出系とその応用2007
- Author(s)
  先浜俊子
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜市
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-18570120
[Presentation] Baculovirus Display系を用いた膜蛋白質相互作用検出法とその応用2007
- Author(s)
  先浜俊子、佐藤敬人、北村俊雄、児玉龍彦、浜窪隆雄
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-18310142
[Presentation] Detection of ligand-recepter interaction between membrane proteins by Baculovirus Display system2007
- Author(s)
  Toshiko Sakihama, Takao Hamakubo., et. al.
- Organizer
  Biochemistry and Molecular Biology
- Place of Presentation
  Yokohama
- Year and Date
  2007-12-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18310142
[Presentation] Baculovirus display系を用いた膜蛋白質間相互作用検出法とその応用2007
- Author(s)
  先浜俊子、佐藤敬人、北村俊雄、児玉龍彦、浜窪隆雄
- Organizer
  日本分子生物学会第30回年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-18570120

1. HAMAKUBO Takao (90198797)

# of Collaborated Projects: 6 results

# of Collaborated Products: 18 results
2. MASUDA Kazuyuki (20345151)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. NAITO Makoto (30045786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MIYOSHI Motosuke (40345137)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. IHARA Shigeo (30345136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MOCHIZUKI Yasuhiro (80282523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. IWANARI Hiroko (20176556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. KAWAMURA Takeshi (70306835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. DAIGO Kenji (20466866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HORIUCHI Keiko (00456203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OHTA Yoshihiro (80436592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OHASHI Riuko (20447600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 田坂捷雄 (40093265)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SAKIHAMA Toshiko 先浜 俊子

先浜 俊子 サキハマ トシコ

Research Projects

Research Products

Co-Researchers

Dynamic Proteomics of Transcriptional and Nuclear Architecture

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of interaction of membrane proteins on immune cells bybaculoviral displayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The targetedproteomics for membrane protein and nuclear protein

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

バキユロウイルスデイスプレイ法を用いた膜蛋白質相互作用の解析と抗体作成への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of membrane protein complex using baculoviral display

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

サイトカインを誘導するマウス自己抗体IgG遺伝子の構造解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A novel screening system for claudin binder using baculoviral display.2011

Author(s)

Journal Title

Data Source

[Journal Article] A method of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells2011

Author(s)

Journal Title

Data Source

[Journal Article] Functional reconstitution of G protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system.2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] A simple detection method forlow-affinity membrane proteininteractions by baculoviral display2008

Author(s)

Journal Title

Data Source

[Journal Article] Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system2008

Author(s)

Journal Title

Data Source

[Journal Article] Functional reconstitution of G protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system2008

Author(s)

Journal Title

Data Source

[Journal Article] A simple detection method for low-affinity membrane protein interactions by baculoviral display2008

Author(s)

Journal Title

Data Source

[Journal Article] Functional reconstitution of G protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system2008

Author(s)

Journal Title

Data Source

[Journal Article] Functionalreconstitusion of G-protein-coupledreceptor-mediated adenylyl cyclaseactivation by a baculoviral co-displaysystem2008

Author(s)

Journal Title

Data Source

[Journal Article] Functional reconstitution of G protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system2008

Author(s)

SAKIHAMA Toshiko 先浜俊子

先浜俊子サキハマトシコ