Kozasa Toru 小笹徹

… Alternative Names

KOZASA Tohru 小笹徹

小笹徹コザサトオル

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Researcher Number	70202059
Affiliation (Current)	2022: 横浜薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2019: 横浜薬科大学, 薬学部, 教授 2010 – 2017: 東京大学, 先端科学技術研究センター, 特任教授 2014: 東京大学, 先端科学技術研究センター, 教授 2011: 東京大学, 先端科学技術センター, 特任教授 2009: 東京大学, 先端科学技術センター, 客員教授 1990: イリノイ大学シカゴ校, 薬理学教室, 客員講師 1989: 東京大学, 医科学研究所, 助手
Review Section/Research Field	Principal Investigator General pharmacology Except Principal Investigator Pediatrics / 代謝生物化学
Keywords	Principal Investigator シグナル伝達 / G蛋白質 / 癌細胞 / Rho / 受容体　シグナル伝達系 / 三量体Gタンパク質 / RhoGTPase / G12/13 / RhoGEF / RhoA … More / クライオ電子顕微鏡 / タンパク質相互作用 / 受容体・シグナル伝達系 / X線結晶構造解析 / 薬理学 / Gタンパク質 / タンパク質構造解析 / タンパク質相互作用解析 … More Except Principal Investigator RH-RhoGEF / Gタンパク質 / rasタンパク質 / 白血病細胞 / 分化 / リン酸化 / リン酸化修飾 / アデニル酸シクラ-ゼ / 小児血液学 / G蛋白質 / ショットガンプロテオミクス / 細胞分化 / 核膜 / Rho活性化因子 / 白血病 / 核エンベロープ / 核移行 / シグナル伝達 / GTP結合タンパク質 / 細胞の増殖と分化 / ヒト染色体遺伝子 / 遺伝子の発現調節 / 百日咳毒素非感受性 / PC12細胞 / 細胞の分化と増殖 / 酵母の接合因子 / 遺伝子クローニング / 平滑筋分化 / 三量体G蛋白 / 血管平滑筋細胞分化 / 三量体G蛋白質G12 / Gbeta / Ggamma / Gα12/13 / Rho活性化調節 / 平滑筋細胞分化 / Rho / G12 / TGFβ Less

Gα13-RhoGEF細胞情報伝達系の構造と分子間相互作用機構の解明Principal Investigator
- Principal Investigator
  
  小笹徹
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Yokohama College of Pharmacy
The role of the heterotrimeric G protein, Galpha12/13 in differentiation and proliferation of smooth muscle cells.
- Principal Investigator
  
  Suzuki Nobuchika
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nippon Medical School
  The University of Tokyo
the mechanism of RH-RhoGEF activation by G12/13Principal Investigator
- Principal Investigator
  
  KOZASA Tohru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  The University of Tokyo
p115RhoGEF promote differentiation of human acute leukemic cells
- Principal Investigator
  
  Suzuki Nobuchika
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokyo
The function of LARG in the nucleus
- Principal Investigator
  
  SUZUKI Nobuchika
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokyo
部位特異的変異法を用いたGsαタンパク質の機能の研究
- Principal Investigator
  
  水島純子 (菅野純子)
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  代謝生物化学
- Research Institution
  The University of Tokyo
シグナル伝達に関与するGTP結合タンパク質の構造と機能
- Principal Investigator
  
  上代淑人
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  The University of Tokyo

All 2014 2013 2012 2011 2009 Other

All Journal Article Presentation

[Journal Article] Gα13/PDZ-RhoGEF/RhoA Signaling Is Essential for Gastrin-Releasing Peptide Receptor-Mediated Colon Cancer Cell Migration.2014
- Author(s)
  Patel M, Kawano T, Suzuki N, Hamakubo T, Karginov AV, Kozasa T.
- Journal Title
  
  Molecular pharmacology
  
  Volume: 86 Pages: 252-262
- DOI
  10.1124/mol.114.093914
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-24108007, KAKENHI-PROJECT-24390060, KAKENHI-PROJECT-24591540, KAKENHI-PROJECT-25220205
[Journal Article] G protein-dependent basal and evoked endothelial cell vWF secretion.2014
- Author(s)
  Rusu L, Andreeva A, Visintine DJ, Kim K, Vogel SM, Stojanovic-Terpo A, Chernaya O, Liu G, Bakhshi FR, Haberichter SL, Iwanari H, Kusano-Arai O, Suzuki N, Hamakubo T, Kozasa T, Cho J, Du X, Minshall RD.
- Journal Title
  
  Blood.
  
  Volume: 123 Pages: 442-450
- DOI
  10.1182/blood-2013-03-489351
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-24108007, KAKENHI-PROJECT-24390060, KAKENHI-PROJECT-24591540, KAKENHI-PROJECT-25220205
[Journal Article] GPCRシグナルの動的作用機構の解明―タンパク質表面のインターフェースに注目した、新たな熱力学的解析2013
- Author(s)
  鈴木信周、小笹徹。
- Journal Title
  
  実験医学
  
  Volume: 31 Pages: 399-405
- Data Source
  KAKENHI-PROJECT-24591540
[Journal Article] Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity.2013
- Author(s)
  CHOW, C. R., SUZUKI, N., KAWAMURA, T., HAMAKUBO, T. & KOZASA, T.
- Journal Title
  
  Cell Signal.
  
  Volume: 25 Pages: 2085-92
- DOI
  10.1016/j.cellsig.2013.06.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591540, KAKENHI-PROJECT-25220205
[Journal Article] Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13.2011
- Author(s)
  KOZASA, T., HAJICEK, N., CHOW, C. R. & SUZUKI, N.
- Journal Title
  
  J Biochem
  
  Volume: 150 Pages: 357-69
- NAID
  10030587857
- Data Source
  KAKENHI-PROJECT-21591348
[Journal Article] Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G132011
- Author(s)
  Kozasa T, Hajicek N, Chow CR, Suzuki N
- Journal Title
  
  J Biochem
  
  Volume: 150 Pages: 357-369
- DOI
  10.1093/jb/mvr105
- NAID
  10030587857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591348
[Journal Article] Regulation and physiological functions of G12/13-mediated signaling pathways.2009
- Author(s)
  SUZUKI, N., HAJICEK, N. & KOZASA, T.
- Journal Title
  
  Neurosignals
  
  Volume: 17 Pages: 55-70
- Data Source
  KAKENHI-PROJECT-21591348
[Journal Article] Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface.2009
- Author(s)
  SUZUKI, N., TSUMOTO, K., HAJICEK, N., DAIGO, K., TOKITA, R., MINAMI, S., KODAMA, T., HAMAKUBO, T. & KOZASA, T.
- Journal Title
  
  J Biol Chem
  
  Volume: 284 Pages: 5000-9
- Data Source
  KAKENHI-PROJECT-21591348
[Presentation] The role of p115RhoGEF during differentiation of human myeloid HL60 leukemia cells2012
- Author(s)
  Nobuchika Suzuki, Takeshi Kawamura, Hiroko Iwanari, Takao Hamakubo, Tohru Kozasa
- Organizer
  Gordon Research Conference
- Place of Presentation
  Univ of New England, USA
- Data Source
  KAKENHI-PROJECT-24591540
[Presentation] p115RH-RhoGEF targets lamin B to promote the differentiation of human leukemic cells
- Author(s)
  SUZUKI, N., KAWAMURA, T., HAJICEK, T, HAMAKUBO, T. & KOZASA, T
- Organizer
  Gordon Research Conference
- Place of Presentation
  University of New England, Biddeford, ME, USA
- Year and Date
  2014-06-15 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-24591540

1. SUZUKI Nobuchika (90247007)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
2. KAWAMURA Takeshi (70306835)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. 水島純子 (80192756)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 上代淑人 (90012690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 中福雅人 (80202216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 伊東広 (10183005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中村俊 (00134619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 柊元睦子 (30321756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. CHANG Kyungho

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. IWANARI Hiroko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 浜窪隆雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Kozasa Toru 小笹 徹

KOZASA Tohru 小笹 徹

小笹 徹 コザサ トオル

Research Projects

Research Products

Co-Researchers

Gα13-RhoGEF細胞情報伝達系の構造と分子間相互作用機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of the heterotrimeric G protein, Galpha12/13 in differentiation and proliferation of smooth muscle cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

the mechanism of RH-RhoGEF activation by G12/13Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

p115RhoGEF promote differentiation of human acute leukemic cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The function of LARG in the nucleus

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

部位特異的変異法を用いたGsαタンパク質の機能の研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

シグナル伝達に関与するGTP結合タンパク質の構造と機能

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Journal Article] Gα13/PDZ-RhoGEF/RhoA Signaling Is Essential for Gastrin-Releasing Peptide Receptor-Mediated Colon Cancer Cell Migration.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] G protein-dependent basal and evoked endothelial cell vWF secretion.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GPCRシグナルの動的作用機構の解明―タンパク質表面のインターフェースに注目した、新たな熱力学的解析2013

Author(s)

Journal Title

Data Source

[Journal Article] Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13.2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G132011

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Regulation and physiological functions of G12/13-mediated signaling pathways.2009

Author(s)

Journal Title

Kozasa Toru 小笹徹

KOZASA Tohru 小笹徹

小笹徹コザサトオル