NISHIYAMA Tsutomu 西山勉

… Alternative Names

西山勉ニシヤマツトム

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Researcher Number	70208239
Other IDs
Affiliation (based on the past Project Information) *help	2009 – 2014: Niigata University, 医歯学系, 准教授 1991: 新潟大学, 医学部附属病院, 講師 1989: 新潟大学, 医学部附属病院, 講師
Review Section/Research Field	Principal Investigator Urology / Urology Except Principal Investigator Urology
Keywords	Principal Investigator 前立腺癌 / アンドロゲン抑制療法 / アンドロゲン受容体 / targeting therapy / T抗原 / Tn抗原 / 膀胱癌 / PNA-ricinA / in vitro / アンドロゲン代謝 … More / 細胞内分泌学 / 細胞内アンドロゲン代謝 / ジヒドロテストステロン / デヒドロエピアンドロステロン / HSD17B6 / 3αアンドロスタンディオール / 下垂体-副腎内分泌軸 / アンドロゲン / アンタゴニスト / アゴニスト / 共役因子 / NKX3.1 / アンドロゲンん / 活性化共役因子 … More Except Principal Investigator 細胞間接着因子 / 腎細胞癌 / フロ-サイトメトリ- Less

Elucidation of agonistic changes of the antagonists of androgen receptor of prostate cancerPrincipal Investigator
- Principal Investigator
  
  NISHIYAMA Tsutomu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Niigata University
Development of intracrine androgen deprivation therapy for prostate cancerPrincipal Investigator
- Principal Investigator
  
  NISHIYAMA Tsutomu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Niigata University
腎細胞癌上におけるICAMー1の表現とサイトカインによる発現の調節(宿主免疫担当細胞に対する感受性の変化)
- Principal Investigator
  
  佐藤昭太郎
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Niigata University
ヒト膀胱癌関連T抗原、Tn抗原特異的バイオミサイル療法の基礎的研究Principal Investigator
- Principal Investigator
  
  西山勉
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Niigata University

All 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

[Book] Androgens: Production, Functions and Disorders. Chapter 1: Androgen deprivation therapy for advanced prostate cancer on the ground of androgen milieu in the prostate2012
- Author(s)
  Nishiyama T
- Publisher
  NOVA SCIENCE PUBLISHERS, INC.
- Data Source
  KAKENHI-PROJECT-24592380
[Book] Paradigm shift in the concept of hormonal milieu of prostate cancer.In Spiess PE ed.PROSTATE CANCER FROM ENCH TO BEDSIDE.Croatia, InTech, 20112011
- Author(s)
  Tsutomu Nishiyama
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-21592035
[Book] Paradigm shift in the concept of hormonal milieu of prostate cancer. In Prostate Cancer-From Bench to Bedside.(Spiess PE ed.)2011
- Author(s)
  Nishiyama T
- Publisher
  In Tech. Croatia
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] Androgen metabolic pathway involved in current and emerging treatment for men with castration resistant prostate cancer: intraprostatic androgens as therapeutic targets and endocrinological biomarkers.2014
- Author(s)
  Hara N, Nishiyama T.
- Journal Title
  
  Curr Drug Targets.
  
  Volume: 15 Pages: 1215-1224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592380
[Journal Article] Serum testosterone levels after medical or surgical androgen deprivation: A comprehensive review of the literature.2014
- Author(s)
  Nishiyama T,
- Journal Title
  
  Urol Oncol.
  
  Volume: 32
- DOI
  10.1016/j.urolonc.2013.03.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592380
[Journal Article] Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer.2013
- Author(s)
  Ishizaki F, Nishiyama T, Kawasaki T, Miyashiro Y, Hara N, Takizawa I, Naito M, Takahashi K.
- Journal Title
  
  Sci Rep.
  
  Volume: 3 Pages: 1528-1528
- DOI
  10.1038/srep01528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592380
[Journal Article] Altered association of interleukin-6 with sex steroids in lipid metabolism disorder in men with prostate cancer receiving androgen deprivation therapy2012
- Author(s)
  Komatsu S, Hara N, Ishizaki F, Nishiyama T, Takizawa I, Isahaya E, Kawasaki T, Takahashi K.
- Journal Title
  
  Prostate.
  
  Volume: (In press) Pages: 1207-1213
- DOI
  10.1002/pros.22471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592035, KAKENHI-PROJECT-21791493, KAKENHI-PROJECT-24592380
[Journal Article] Androgen deprivation therapy in combination with radiotherapy for high-risk clinically localized prostate cancer.2012
- Author(s)
  Nishiyama T.
- Journal Title
  
  J Steroid Biochem Mol Biol.
  
  Volume: 129 Pages: 179-190
- DOI
  10.1016/j.jsbmb.2011.12.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592380
[Journal Article] Deficiency in androgens and upregulation of insulin-like growth factor-1 are involved in high bone turnover in men receiving androgen deprivation therapy for prostate cancer.2012
- Author(s)
  Ishizaki F, Hara N, Takizawa I, Nishiyama T, Isahaya E, Kawasaki T, Takahashi K.
- Journal Title
  
  Growth Horm IGF Res.
  
  Volume: 22 Pages: 122-128
- DOI
  10.1016/j.ghir.2012.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592380
[Journal Article] Androgen deprivation therapy in combination with radiotherapy for high-risk clinically localized prostate cancer2012
- Author(s)
  Nishiyama T
- Journal Title
  
  J steroid Biochem Mol Biol.2012 Apr; 129(3-5) : 179-90
  
  Volume: 129 Pages: 179-190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] Androgen deprivation therapy in combination with radiotherapy for high-risk clinically localized prostate cancer2012
- Author(s)
  Nishiyama T
- Journal Title
  
  J Steroid Biochem Mol Biol
  
  Volume: 129(3-5) Pages: 179-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] アンドロゲン合成阻害剤と新規アンドロゲン受容体拮抗剤2011
- Author(s)
  西山勉
- Journal Title
  
  日本臨床
  
  Volume: 69 Suppl 5 Pages: 511-515
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] II臨床6)内分泌療法c.内分泌療法の新展開d)アンドロゲン合成阻害剤と新規アンドロゲン受容体拮抗剤日本臨牀69巻増刊号5前立腺癌(第2版)2011
- Author(s)
  西山勉
- Journal Title
  
  日本臨牀
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] 前立腺癌ホルモン環境概念のパラダイムシフト2011
- Author(s)
  西山勉
- Journal Title
  
  新潟医学会雑誌
  
  Volume: 125 Pages: 581-601
- NAID
  120006748441
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] Insulin-like growth factorl is associated with regulation of the luteinizing hormone production in men receiving androgen deprivation therapy with gonadotropin-releasing hormone analogues for localized prostate cancer.2011
- Author(s)
  Hara N, Takizawa I, Isahaya E, Nishiyama T, Hoshii T, Ishizaki F, Takahashi K.
- Journal Title
  
  Urol Oncol.2011 Mar 30
  
  Volume: (電子版 Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] Insulin-like growth factor-1 is associated with regulation of the luteinizing hormone production in men receiving androgen deprivation therapy with gonadotropin-releasing hormone analogues for localized prostate cancer2011
- Author(s)
  Hara N, Takizawa I, Isahaya E, Nishiyama T, Hoshii T, Ishizaki F, Takahashi K
- Journal Title
  
  Urol Oncol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] Adrenocorticotropic hormone is involved in regulation of androgen synthesis in men receiving androgen deprivation therapy for localized prostate cancer.2010
- Author(s)
  Takizawa I, Hara N, Nishiyama T, Isahaya E, Hoshii T, Takahashi K.
- Journal Title
  
  JUrol.184(5), 2010.
  
  Volume: 184 Pages: 1971-1976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] Serum prostate-specific antigen levels reflect the androgen milieu in patients with localized prostate cancer receiving androgen deprivation therapy : Tumor malignant potential and androgen milieu.2010
- Author(s)
  Takizawa I, Nishiyama T, Hara N, Isahaya E, Hoshii T, Takahashi K.
- Journal Title
  
  Prostate.70(13)1395-401, 2010.
  
  Volume: 70 Pages: 1395-1401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] Decline of the red blood cell count in patients receiving androgen deprivation therapy for localized prostate cancer : impact of ADT on insulin-like growth factor-1 and erythropoiesis2010
- Author(s)
  Hara N, Nishiyama T, Takizawa I, Saito T, Kitamura Y, Takahashi K
- Journal Title
  
  Urology
  
  Volume: 75(6) Pages: 1441-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] Bone metabolic disorder in patients with prostate cancer receiving androgen deprivation therapy(ADT): impact of ADT on the growth hormone/insulin-like growth factor-1/parathyroid hormone axis2010
- Author(s)
  Isahaya E, Hara N, Nishiyama T, Hoshii T, Takizawa I, Takahashi K
- Journal Title
  
  Prostate
  
  Volume: 70(2) Pages: 155-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] Prostate cancer and androgens : new strategies of androgen deprivation therapy2010
- Author(s)
  Nishiyama T
- Journal Title
  
  Curr Top Steroid Res
  
  Volume: 7 Pages: 35-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] Serum prostate-specific antigen levels reflect the androgen milieu in patients with localized prostate cancer receiving androgen deprivation therapy : Tumor malignant potential and androgen milieu2010
- Author(s)
  Takizawa I, Nishiyama T, Hara N, Isahaya E, Hoshii T, Takahashi K
- Journal Title
  
  Prostate
  
  Volume: 70(13) Pages: 1395-401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] Decline of the Red Blood Cell Count in Patients Receiving Androgen Deprivation Therapy for Localized Prostate Cancer : Impact of ADT on Insul in-like Growth Factor-1 and Erythropoiesis.2010
- Author(s)
  Hara N, Nishiyama T, Takizawa I, Saito T, Kitamura Y, Takahashi K.
- Journal Title
  
  Urology. 75(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] Trilostane, an inhibitor of 3β-hydroxysteroid dehydrogenase, has an agonistic activity on androgen receptor in human prostate cancer cells.2010
- Author(s)
  Takizawa I, Nishiyama T, Hara N, Hoshii T, Ishizaki F, Miyashiro Y, Takahashi K.
- Journal Title
  
  Cancer Lett.297(2)226-30, 2010.
  
  Volume: 297 Pages: 226-230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] Adrenocorticotropic hormone is involved in regulation of androgen synthesis in men receiving androgen deprivation therapy for localized prostate cancer2010
- Author(s)
  Takizawa I, Hara N, Nishiyama T, Isahaya E, Hoshii T, Takahashi K
- Journal Title
  
  J Urol
  
  Volume: 184(5) Pages: 1971-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] an inhibitor of 3β-hydroxysteroid dehydrogenase, has an agonistic activity on androgen receptor in human prostate cancer cells2010
- Author(s)
  Takizawa I, Nishiyama T, Hara N, Hoshii T, Ishizaki F, Miyashiro Y, Takahashi K. Trilostane
- Journal Title
  
  Cancer Lett
  
  Volume: 297(2) Pages: 226-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] Bone metabolic disorder in patients with prostate cancer receiving and rogen deprivation therapy(ADT) : impact of ADT on the growth hormone/insulin-like growth factor-1/parathyroid hormone axis.2010
- Author(s)
  Isahaya E, Hara N, Nishiyama T, Hoshii T, Takizawa I, Takahashi K.
- Journal Title
  
  Prostate. 2010 Feb 1 ; 70(2): 70
  
  Pages: 155-161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] 前立腺癌とアンドロゲン-アンドロゲン抑制療法の新たな挑戦2009
- Author(s)
  西山勉
- Journal Title
  
  Urology Today
  
  Volume: 16(2) Pages: 50-54
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] Altered association of interleukin-6 with sex steroids in lipid metabolism disorder in men with prostate cancer receiving androgen deprivation therapy
- Author(s)
  Komatsu S, Hara N, Ishizaki F, Nishiyama T, Takizawa I, Isahaya E, Kawasaki T, Takahashi K
- Journal Title
  
  Prostate.2011 Dec 27.doi : 10.1002/pros.22471
  
  Volume: (Epub ahead of print)(未定)(Online先行掲載)(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592035
[Journal Article] Insulin-like growth factor-1 is associated with regulation of the luteinizing hormone production in men receiving androgen deprivation therapy with gonadotropin-releasing hormone analogues for localized prostate cancer
- Author(s)
  Hara N, Takizawa I, Isahaya E, Nishiyama T, Hoshii T, Ishizaki F, Takahashi K.
- Journal Title
  
  Urol Oncol.2011 Mar 30
  
  Volume: (Epub ahead of print)(未定)(Online先行掲載)(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592035
[Presentation] 前立腺癌アンドロゲンレセプターに対する抗アンドロゲン剤のアゴニスト化のメカニズム：共調節因子の発現および機能の変化2015
- Author(s)
  武田啓介、西山勉
- Organizer
  第103回日本泌尿器科学会総会
- Place of Presentation
  金沢、ホテル日航金沢
- Year and Date
  2015-04-19
- Data Source
  KAKENHI-PROJECT-24592380
[Presentation] スポンサードセミナー「前立腺組織内環境からみた前立腺癌アンドロゲン抑制療法」2011
- Author(s)
  西山勉
- Organizer
  第63回日本泌尿器科学会西日本総会
- Place of Presentation
  久留米
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-21592035
[Presentation] 5 a-androstane-3a 17b-diol will be a p otential precursor of the most active androgen 5a-dihydrotestosterone in prostate cancer2011
- Author(s)
  Nishiyama T, Ishizaki F, Hara N, K awasaki T, Miyashiro Y, Takizawa I, Hoshii T, Naito M, Takahashi K
- Organizer
  AUA annual meeting
- Place of Presentation
  Washington DC, USA
- Year and Date
  2011-05-15
- Data Source
  KAKENHI-PROJECT-21592035
[Presentation] 5 α ANDROSTANE-3 α 17 β-DIOL WILL BE A POTENTIAL PRECURSOR OF THE MOST ACTIVE ANDROGEN 5 α-DIHYDROTESTOSTERONE IN PROSTATE CANCER2011
- Author(s)
  Tsutomu Nishiyama, Fumio Ishizaki, Itsuhiro Takizawa, Kazutoshi Yamana, Noboru Hara, Kota Takahashi
- Organizer
  American Urological Association 2011 annual meeting
- Place of Presentation
  Washington, USA. Walter E.Washington Convertion Center
- Year and Date
  2011-05-15
- Data Source
  KAKENHI-PROJECT-21592035
[Presentation] ホルモン抵抗性前立腺癌概念のparadigm shift2010
- Author(s)
  西山勉
- Organizer
  日本泌尿器科学会東部総会教育講演
- Place of Presentation
  宇都宮
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-21592035
[Presentation] ホルモン抵抗性前立腺癌概念のparadigm shift2010
- Author(s)
  西山勉
- Organizer
  第75回日本泌尿器科学会東部総会
- Place of Presentation
  宇都宮
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-21592035
[Presentation] an inhibitor of 3β-HSD, has an agonistic activity for androge n receptors in the prostate cancer ce lls2010
- Author(s)
  Nishiyama T, Takizawa I, Hoshii T, Kasahara T, Hara N, Takahashi K, Trilostane
- Organizer
  AUA annual meeting
- Place of Presentation
  San Franci sco, USA
- Year and Date
  2010-05-30
- Data Source
  KAKENHI-PROJECT-21592035
[Presentation] Trilostane, an inhibitor of 3β-HSD, has an agonistic activity for androgen receptors in the prostate cancer cells.2010
- Author(s)
  Nishiyama T, Takizawa I, Hoshii T, Kasahara T, Hara N, Takahashi K
- Organizer
  アメリカ泌尿器科学会年次総会
- Place of Presentation
  サンフランシスコ
- Year and Date
  2010-05-30
- Data Source
  KAKENHI-PROJECT-21592035
[Presentation] アンドロゲン合成阻害剤と新規アンドロゲン受容体拮抗剤2010
- Author(s)
  西山勉
- Organizer
  第17回東京前立腺がんフォーラム
- Place of Presentation
  東京
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-21592035
[Presentation] The expression features o f androgen-metabolic genes involving intracrine production of androgens i n the prostate cancer cells2009
- Author(s)
  Nishiyama T, Hara N, Yamana K, K Suzuki K, Hoshii T, Takizawa I, Ta kahashi K.
- Organizer
  AUA annual meeting
- Place of Presentation
  Chicago, USA
- Year and Date
  2009-04-26
- Data Source
  KAKENHI-PROJECT-21592035
[Presentation] The expression features of androgen- metabolic genes involving intracrine production of androgens in the prostate cancer cells2009
- Author(s)
  西山勉
- Organizer
  アメリカ泌尿器科学会年次総会
- Place of Presentation
  シカゴ
- Year and Date
  2009-04-26
- Data Source
  KAKENHI-PROJECT-21592035
[Presentation] NKX3-1 and RAB3B as possible major coactivators inducing agonistic effects in androgen receptor-androgen receptor antagonist interaction
- Author(s)
  Nishiyama T, Takeda K, Hara H, Ishizaki F, Takahashi K
- Organizer
  SIU annual meeting
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-24592380

1. 佐藤昭太郎 (30018288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 富田善彦 (90237123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. HARA Noboru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NISHIYAMA Tsutomu 西山 勉

西山 勉 ニシヤマ ツトム

Research Projects

Research Products

Co-Researchers

Elucidation of agonistic changes of the antagonists of androgen receptor of prostate cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of intracrine androgen deprivation therapy for prostate cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腎細胞癌上におけるICAMー1の表現とサイトカインによる発現の調節(宿主免疫担当細胞に対する感受性の変化)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト膀胱癌関連T抗原、Tn抗原特異的バイオミサイル療法の基礎的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Androgens: Production, Functions and Disorders. Chapter 1: Androgen deprivation therapy for advanced prostate cancer on the ground of androgen milieu in the prostate2012

Author(s)

Publisher

Data Source

[Book] Paradigm shift in the concept of hormonal milieu of prostate cancer.In Spiess PE ed.PROSTATE CANCER FROM ENCH TO BEDSIDE.Croatia, InTech, 20112011

Author(s)

Publisher

Data Source

[Book] Paradigm shift in the concept of hormonal milieu of prostate cancer. In Prostate Cancer-From Bench to Bedside.(Spiess PE ed.)2011

Author(s)

Publisher

Data Source

[Journal Article] Androgen metabolic pathway involved in current and emerging treatment for men with castration resistant prostate cancer: intraprostatic androgens as therapeutic targets and endocrinological biomarkers.2014

Author(s)

Journal Title

Data Source

[Journal Article] Serum testosterone levels after medical or surgical androgen deprivation: A comprehensive review of the literature.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Altered association of interleukin-6 with sex steroids in lipid metabolism disorder in men with prostate cancer receiving androgen deprivation therapy2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Androgen deprivation therapy in combination with radiotherapy for high-risk clinically localized prostate cancer.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deficiency in androgens and upregulation of insulin-like growth factor-1 are involved in high bone turnover in men receiving androgen deprivation therapy for prostate cancer.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Androgen deprivation therapy in combination with radiotherapy for high-risk clinically localized prostate cancer2012

Author(s)

Journal Title

Data Source

[Journal Article] Androgen deprivation therapy in combination with radiotherapy for high-risk clinically localized prostate cancer2012

Author(s)

Journal Title

Data Source

[Journal Article] アンドロゲン合成阻害剤と新規アンドロゲン受容体拮抗剤2011

Author(s)

NISHIYAMA Tsutomu 西山勉

西山勉ニシヤマツトム