KASAHARA Akinori 笠原彰紀

Researcher Number	70214286
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2015: 大阪大学, 医学部附属病院, 教授 2014: 大阪大学, 医学部附属病院, 特任教授 2012 – 2013: 大阪大学, 医学(系)研究科(研究院), 准教授 2012: 大阪大学, 大学院・医学系研究科, 准教授 2007 – 2011: Osaka University, 医学系研究科, 准教授 … More 1997 – 2000: Osaka University Hospital, Associate Professor, 医学部・附属病院, 助教授 1997 – 1998: 大阪大学, 医学部・付属病院, 助教授 1989 – 1996: Osaka University Medical School Assistant, 医学部, 助手 1988: Osaka University Hospital, Resident, 医学部附属病院, 医員 1987: 大阪大学, 医学部付属病院, 医員 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology / Medical sociology / 医学一般
Keywords	Principal Investigator C型肝炎 / B7-1 / 肝細胞癌 / 樹状細胞 / インターフェロン / hepatocellular carcinoma / アポトーシス / c-met / Fas ligand / Fas抗原 … More / C型慢性肝炎 / interferon / IL-12 / dendric cell / TAP / extended haplotype / Hepatitis C virus / Fas / 遺伝子診断 / B型肝炎 / ERK / MAPK / TAP2 / HLA / Gene Therapy / Ribozyme / Interferon / Apoptosis / Fas Antigen / Hepatitis C Virus / テロメラーゼ / 遺伝子導入 / リボザイム / VPF-VEDF / Fas antigen / Hepatitis C / C型慢性肝疾患 / C-met / VEDF / VPF / NK細胞 / トリプトファン / キヌレニン / IDO / HCV / 性差 / 制御性T細胞 / リバビリン / ペグインターフェロンα … More Except Principal Investigator 肝癌 / C型肝炎ウイルス / c-met / HGF / PKC / HBV / 遺伝子治療 / Fas抗原 / HCC / C型肝炎 / HCV RNA / proto-oncogene / liver regeneration / 肝再生 / ninjurin / HBc / HLA / Hepatitis C virus / Apoptosis / アポトーシス / asialoglycoprotein / cationic liposome / in vivo gene transfer / in vivo遺伝子導入 / アシアログリコプロテイン / 陽電荷リポソーム / 遺伝子導入 / RT-PCR / RGM-1 / Fas antigen / hepatocarcinogenesis / hepatitis C virus / C型慢性肝炎 / bcl-2 / apoptosis / 癌遺伝子 / X遺伝子 / B型肝炎ウイルス / replication / carcinogenesis / oncogene / chronic liver disease / 慢性肝炎 / 免疫組織化学 / 慢性肝疾患 / "in situ"hybridization / DNA / B型肝炎 / WWW / 医学教育 / space among scatterers / cepstrum analysis / frequency dependent attenuation / ultrasonic tissue characterization / kurtosis / 散乱体間距離 / cepstrum / 組織性状診断 / 超音波 / 超音波散乱体間距離 / ケプストラム解析 / 周波数依存減衰率 / 超音波組織性状診断 / signal transduction / c-Ha-ras / c-myc / c-fos / c-kinase / 細胞性癌遺伝子 / 肝細胞増殖機構 / DNA合成 / 細胞情報伝達 / 肝細胞増殖 / がん遺伝子 / アルコール / viral replication / anti-HBx / HBxAg / hepatocytotoxity / hepatoma / X-gene / type B hepatitis / 肝硬変 / HBウィルス / ウィルス増殖 / HBx抗体 / HBx抗原 / 肝炎進展 / hepatocellular carcinoma / adhesion molecule / 診断法 / 治療法 / 接着分子 / Hepatoma cell line / Replicative intermediate / Packaging / Virus particle / Hepatitis B virus / Single-chain antibody / sFv / 単鎖状体 / HBc抗原 / DNAワクチン / single-chain抗体 / 肝癌細胞株 / 複製中間体 / パッケージング / ウイルス粒子 / 単鎖抗体 / TGF-beta1 / Cytotoxic T Lymphocyte / B7-1 (CD80) / Soluble Fas Antigen / Fas Antigen / Hepatitis C Virus / インターフェロン / HLAクラスI / B7-2遺伝子 / B7-1遺伝子 / セカンドシグナル / TGF-α1 / リボザイム / TGF-β1 / 細胞障害性Tリンパ球 / B7-1(CD80) / 可溶性Fas抗原 / Liver cancer / Gene therapy / Intracellular signal transduction / 細胞内情報伝達 / Natural killer cell / Cytotoxic T cell / Humanleukocyte Antigen / Chronic hepatitis C / Human Fas ligand / クローニング / ラットFasリガンド / ヒトFasリガンド / NK細胞 / 細胞障害性T細胞 / HLA抗原 / C型肝炎ウイルス粒子 / ヒト Fas リガンド / Fas 抗原 / selective gene delivery to the hepatocytes / gene therapy / carrier-DNA ratio / chloroquine / in vitro gene transfer / 肝細胞 / HcpG2 / βガラクトシダーゼ / ウイルス肝炎 / アンチセンスDNA / 肝特異的遺伝子導入 / carrier-DNA比 / クロロキン / アシアロ糖タンパク / in vitro遺伝子導入 / expression vector / liver injury / rat / 肝炎 / Lac Z / PCR / リポソーム / C形肝炎ウィルス / β-ガラクトシダーゼ / 肝発泡機構 / 発現ベクター / 肝発癌機構 / 肝炎発症機序 / ラット / TGF-alpha / gastric cancer / ammonia / mucosal regeneration / gastric mucosal cell / Protein kinase C / ヘリコバクタピロリ / 細胞内カルシウム / Hepatocyte Growth Factor / Epidermal Growth Factor / 消化管ホルモン / TGFα / TGF-α / 胃癌 / アンモニア / 胃粘膜再生 / 胃粘膜細胞 / genotype / RT-PCR法 / HCV抗原 / モノクローナル抗体 / HCV / Genotype / HLA class I Antigen / x-protein / x-gene / hepatitis B Virus / X抗体 / X蛋白 / integration / Hcc / hepatitis B vins / HLA class I antigen / Xーprotein / Xーgene / hepatitis B vines / "in situ" hybridization / Immunohistochemical staining / Interferon therapy / Viral replication / polymerase chain reaction / hapatitis C virus / HCVーRNA / 肝病変 / 非A非B型慢性肝疾患 / “in situ"hybridization / ウイルス量 / NCV RNA / PCR法 / 免疫組織化学染色 / インターフェロン療法 / ウイルス増殖 / HCVキャリア / HCV抗体 / Proto-oncogene / Gene expression / プロトオンコジ-ン / 遺伝子発現 / Molecular Biology / Type B Hepatitis / 分子生物学 / ネットワーク / コンピューター / EBM / コンピュータネットワーク / 臨床実習 / コンピュータ / ファイリングシステム / 総合診察 / コミュニケーション / ビデオ / ホームページ / グラフィック / 視聴覚教育 Less

The role of NK cell in the patients with hepatitis C virus infection; analysis focusing on NK cell receptor and IFN signal transducerPrincipal Investigator
- Principal Investigator
  
  Kasahara Akinori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Investigation for the mechanisms of immune tolerance against HCV mediated by tryptophan-catalyzing enzyme, IDOPrincipal Investigator
- Principal Investigator
  
  KASAHARA Akinori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Developmental research of tailored immune-modulation therapy against refractory chronic hepatitis C.Principal Investigator
- Principal Investigator
  
  KASAHARA Akinori
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
マルチメディア系ソフトをもちいた臨床教育ファイリングシステムの構築
- Principal Investigator
  
  平出敦
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical sociology
- Research Institution
  Osaka University
Application of Ninjurin, a novel adhesion molecule, to diagnosis and therapeutics of primary hepatocellular carcinoma
- Principal Investigator
  
  SASAKI Yutaka
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
視聴覚教育による自己学習能力と問題解決能力の啓発
- Principal Investigator
  
  吉矢生人
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical sociology
- Research Institution
  Osaka University
Analysis of the molecular mechanism of hepatocarcinogenesis in patients with chronic viral diseases and its application for genetic diagnosis of hepatocellular carcinoma.Principal Investigator
- Principal Investigator
  
  KASAHARA Akinori
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Therapeutic approach to hepatitis C by regulation of apoptosis-related gene
- Principal Investigator
  
  HAYASHI Norio
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Therapeutic approach to hepatitis C using single-chain antibody and DNA gene transfer
- Principal Investigator
  
  HAYASHI Norio
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Analysis of the mechanism of liver damage and carcinogenesis in patients with chronic hepatitis C virus infection.Principal Investigator
- Principal Investigator
  
  KASAHARA Akinori
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Basic study for gene therapy of human liver cancer in terms of regulating signal trnasduction pathway
- Principal Investigator
  
  SASAKI Yutaka
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Research of gene therapy for viral hepatitis using anti-sense DNA
- Principal Investigator
  
  HAYASHI Norio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Investigation for induction of apoptosis-related genes in hepatitis C virus-infected hepatocytes.
- Principal Investigator
  
  FUSAMOTO Hideyuki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Biomolecular analysis of liver carcinogenesis in hepatitis C virus infection.Principal Investigator
- Principal Investigator
  
  KASAHARA Akinori
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Pathogenesis of liver injury and carcinogenesis in HCV-expressing model animals by in vivo gene transfer.
- Principal Investigator
  
  KAMADA Takenobu
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Analysis of hepatocarcinogenesis induced by hepatitis C virus-mediated host gene activation
- Principal Investigator
  
  HAYASHI Norio
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Molecular and Cell Biology of Gastric Mucosal Regeneration
- Principal Investigator
  
  FUSAMOTO Hideyuki
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Analysis of the mechanism of liver injury and carcinogenesis in HCV infection
- Principal Investigator
  
  KAMADA Takenobu
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Study on the effects of hepatites B virus X-gene expression on hepato-carcinogenesis.
- Principal Investigator
  
  HAYASHI Norio
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Molecular Biological Study on the Mechanism of Hepatocellular Injury of type B Hepatitis
- Principal Investigator
  
  FUSAMOTO Hideyuki
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Development of a System for Analyzing Gene Expression in Small Specimen of Human Liver Tissue
- Principal Investigator
  
  FUSAMOTO Hideyuki
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B).
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Signal transduction for liver cell proliferation and its regulation.
- Principal Investigator
  
  HAYASHI Norio
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Development of Ultrasonic Two-dimensional Tissue Characterization System
- Principal Investigator
  
  HAYASHI Norio
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  医学一般
- Research Institution
  Osaka University
Study on the relationship between the expression of HBV X gene and type B hepatitis or hepatocellular carcinoma
- Principal Investigator
  
  KAMADA Takenobu
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  OSAKA UNIVERSITY
Analysis of inhibitory mechanism by ethanol on liver regeneration.
- Principal Investigator
  
  FUSAMOTO Hideyuki
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University

All 2015 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] The prospective randomized study on telaprevir at 1500 or 2250 mg with pegylated interferon plus ribavirin in Japanese patients with HCV genotype 1.2015
- Author(s)
  Oze T, Hiramatsu N, Yoshida Y et al.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 50 Issue: 3 Pages: 313-322
- DOI
  10.1007/s00535-014-0965-8
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590975, KAKENHI-PROJECT-25460993, KAKENHI-PROJECT-26461001, KAKENHI-PROJECT-26860503
[Journal Article] Association of enhanced activity of indoleamine 2,3-dioxygenase in dendritic cells with the induction of regulatory T cells in chronic hepatitis C infection2013
- Author(s)
  Higashitani, K., Kanto, T., Kuroda, S., Yoshio, S., Matsubara, T., Kakita, N., Oze, T., Miyazaki, M., Sakakibara, M., Hiramatsu, N., Mita, E., Imai, Y., Kasahara, A., Okuno, A., Takikawa, O., Hayashi, N. and Takehara, T.
- Journal Title
  
  J Gastroenterol
- NAID
  10031177017
- Data Source
  KAKENHI-PROJECT-22590730
[Journal Article] Dynamics of regulatory T cells and plasmacytoid dendritic cells as immune markers for virological response in pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C patients.2012
- Author(s)
  Kanto, T. *, Inoue, M., Oze, T., Miyazaki, M., Sakakibara, M., Kakita, N., Matsubara, T., Higashitani, K., Hagiwara, H., Iio, S., Katayama, K., Mita, E., Kasahara, A., Hiramatsu, N., Takehara, T. and Hayashi, N.
- Journal Title
  
  J Gastroenterol
  
  Volume: 47 Pages: 169-178
- Data Source
  KAKENHI-PROJECT-22590730
[Journal Article] Efficacy of pegylated interferon plus ribavirin combination therapy for hepatitis C patients with normal ALT levels: a matched case-control study.2011
- Author(s)
  Hiramatsu, N., Inoue, Y., Oze, T., Kurashige, N., Yakushijin, T., Mochizuki, K., Miyagi, T., Tatsumi, T., Kiso, S., Kanto, T., Kasahara, A., Takehara, T., Oshita, M., Mita, E., Hagiwara, H., Inui, Y., Katayama, K., Tamura, S., Yoshihara, H., Imai, Y. and
- Journal Title
  
  J Gastroenterol
  
  Volume: 46 Pages: 1335-1343
- NAID
  10030295018
- Data Source
  KAKENHI-PROJECT-22590730
[Journal Article] Amino acid substitution in the core protein has no impact on relapse in hepatitis C genotype 1 patients treated withpeginterferon and ribavirin.2011
- Author(s)
  Inoue, Y., Hiramatsu, N., Oze, T., Yakushijin, T., Mochizuki, K., Fukuda, K., Mita, E., Haruna, Y ., Inoue, A., Imai, Y., Hosui, A., Miyagi, T., Yoshida, Y., Tatsumi, T., Kiso, S., Kanto, T., Kasahara, A., Takehara, T. and Hayashi, N. *
- Journal Title
  
  J Med Virol
  
  Volume: 83 Pages: 419-427
- Data Source
  KAKENHI-PROJECT-22590730
[Journal Article] Lamivudine-to-entecavir switching treatment in type B chronic hepatitis patients without evidence of lamivudine resistance2009
- Author(s)
  Kurashige, N., Ohkawa K. Hiramatsu, N., Yakushijin, T., Mochizuki, K., Oze, T., Kiso, S., Kanto, T., Takehara, T., Kasahara, A., Doi, Y., Yamada, A., Fukuda, K., Oshita, M., Mita, E., Fukui, H., Nagase, T., Yoshihara, H., Imai, Y., Kato, M., Kashihara, T. Kurashige, N
- Journal Title
  
  Journal of Gastroenterology 44
  
  Pages: 864-870
- NAID
  10025176735
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590764
[Journal Article] Reduced risk of hepatocellular carcinoma after interferon therapy in aged patients with chronic hepatitis C is limited to sustained virological responders2009
- Author(s)
  Imai, Y., Tamura, S.,. Tanaka, H., Hiramatsu, N., Kiso, Y., Doi, Y., Inada, M., Nagase, T., Kitada, T., Imanaka, K., Fukuda, K., Takehara, T., Kasahara, A., Hayashi, N.
- Journal Title
  
  Journal of Viral Hepatitis (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590764
[Journal Article] Enhanced ability of regulatory T cells in chronic hepatitis C patients with persistently normal alanine aminotransferase levels than those with active hepatitis2009
- Author(s)
  Itose, I., Kanto, T. Kakita, N., Takebe, S., Inoue, M., Higashitani, K., Miyazaki, M., Miyatake, H., Sakakibara, M., Hiramatsu, N., Takehara, T., Kasahara, A., Hayashi, N.
- Journal Title
  
  than those with active hepatitis. Journal of Viral Hepatitis 16
  
  Pages: 846-852
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590764
[Journal Article] Molecular insights into (beta)-galactoside (alpha)2, 6-sialyltransferase secretion in vivo2009
- Author(s)
  Kitazume, S., Oka, R. Ogawa, K., Futakawa, S., Hagiwara, Y., Takigawa, H., Kato, M., Kasahara, A., Miyoshi, E., Taniguchi, N., Hashimoto, Y.
- Journal Title
  
  Glycobiology 19
  
  Pages: 479-487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590764
[Journal Article] new prognostic system for hepatocellular carcinoma including recurrent cases: a study of 861 patients in a single institution2008
- Author(s)
  Toyama T., Hiramatsu N. Yakushijin, T., Oze, T., Nakanishi, F., Yasumaru, M., Mochizuki, K., Kanto, T., Takehara, T., Kasahara, A., Hayashi, N.
- Journal Title
  
  Journal of Clinical Gastroenterology 42
  
  Pages: 317-322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590764
[Journal Article] Repeated administration of recombinant human serum albumin caused no serious allergic reactions in patients with liver cirrhosis-a multicenter clinical study2008
- Author(s)
  Kasahara A, Kita K., et al.
- Journal Title
  
  Journal of Gastroenterology 43
  
  Pages: 464-472
- NAID
  10021269192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590764
[Journal Article] Site-specific analysis of N-glycans on haptoglobin in sera of patients with pancreatic cancer: A novel approach for the development of tumor markers2008
- Author(s)
  Nakano M., Nakagawa T. Ito T, Kitada T, Hijioka T, Kasahara A, Tajiri M, Wada Y, Taniguchi N, Miyoshi E.
- Journal Title
  
  nternational Journal of Cancer 122
  
  Pages: 2301-2309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590764
[Journal Article] Declining incidence of hepatocellular carcinoma in Osaka, Japan, from 1990-20032008
- Author(s)
  Tanaka H., Imai Y. Hiramatsu N, Ito Y, Imanaka K, Oshita M, Hijioka T, Katayama K, Yabuuchi I, Yoshihara H, Inoue A, Kato M, Takehara T, Tamura S, Kasahara A, Hayashi N, Tsukuma H.
- Journal Title
  
  Annals of Internal Medicine 148
  
  Pages: 820-826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590764
[Journal Article] Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virusinfection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I Journal of Medical Virology2008
- Author(s)
  Miyazaki M., Kanto T., Inoue, M., Itose, I., Miyatake, H., Sakakibara, M., Yakushijin, T., Kakita, N., Hiramatsu, N., Takehara, T., Kasahara, A., Hayashi, N.
- Journal Title
  
  80
  
  Pages: 980-988
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590764
[Journal Article] Initial viral response is the most powerful predictor of the emergence of YMDD mutant virus in chronic hepatitis B patients treated with lamivudine2008
- Author(s)
  Kurashige N., Hiramatsu N. Ohkawa, K., Oze, T., Inoue, Y., Kurokawa, M., Yakushijin, T., Igura, T., Kiso, S., Kanto, T., Takehara, T., Tamura, S., Kasahara, A., Oshita, M., Hijioka, T., Katayama, K., Yoshihara, H., Hayashi, E., Imai, Y., Kato, M., HayashiKura
- Journal Title
  
  Hepatology Research 38
  
  Pages: 450-456
- NAID
  10024148320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590764
[Journal Article] Early decline of hemoglobin can predict progression of hemolytic anemia during pegylated interferon and ribavirin combination therapy in patients with chronic hepatitis C2008
- Author(s)
  iramatsu N, Kurashige N, Oze T, Takehara T, Tamura S, Kasahara A, Oshita M, Katayama K, Yoshihara H, Imai Y, Kato M, Kawata S, Tsubouchi H, Kumada H, Okanoue T, Kakumu S, Hayashi N.
- Journal Title
  
  Hepatology Research 38
  
  Pages: 52-59
- NAID
  10020116973
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590764
[Journal Article] Repeated administration of recombinant human serum albumin caused no serious allergic reactions in patients with liver cirrhosis-a multicenter clinical study Journal of Gastroenterology2008
- Author(s)
  Kasahara A, Kita K., Tomita E, Toyota J, Imai Y, Kumada H.
- Journal Title
  
  43
  
  Pages: 464-472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590764
[Journal Article] Involvement of dendritic cell frequency and function in virological relapse in pegylated interferon-α2b and ribavirin therapy for chronic hepatitis C patients2007
- Author(s)
  Itose I., Kanto T., Inoue, M., Miyazaki, M., Miyatake, H., Sakakibara, M., Yakushijin, T., Oze, T., Hiramatsu, N., Takehara, T., Kasahara, A., Hayashi, N.
- Journal Title
  
  ournal of Medical Virology 79
  
  Pages: 511-521
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590764
[Journal Article] Impaired ability of interferon-alpha-primed dendritic cells to stimulate Th1-type CD4 T cell response in chronic hepatitis C virus infection2007
- Author(s)
  Miyatake H., Kanto T., Inoue, M., Sakakibara, M., Kaimori, A., Yakushijin, T., Itose, I., Miyazaki, M., Kuzushita, N., Hiramatsu, N., Takehara, T., Kasahara, A., Hayashi, N.
- Journal Title
  
  Journal of Viral Hepatitis 14
  
  Pages: 404-412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590764
[Presentation] Association of indoleamine 2,3-dioxygenase in dendritic cells with the generation ofregulatory T cells in chronic hepatitis C patients2012
- Author(s)
  Higashitani K, Kanto T, Kuroda S, Yoshio S, Matsubara T, Kakita N, Oze T, Hiramatsu N, Mita E, Imai Y, Kasahara A, Okuno A, Takikawa O, Hayashi N, Takehara T
- Organizer
  The Liver Meeting AASLD 63rd Annual Meeting and Postgraduate Course
- Place of Presentation
  Boston, MA, USA
- Year and Date
  2012-11-10
- Data Source
  KAKENHI-PROJECT-22590730
[Presentation] Enhanced ability of IL28A and IL28B induction in plasmacytoid dendritic cells in chronic hepatitis C patients with major allele of IL28B single nucleotide polymorphism.2011
- Author(s)
  Kakita N, Kanto T, Miyazaki M, Yoshio S, Kuroda S, Matsubara T, Higashitani K, Sakakibara M, Hiramatsu N, Kasahara A, Takehara T, Hayashi N
- Organizer
  The Liver Meeting AASLD 62nd Annual Meeting and Postgraduate Course
- Place of Presentation
  San Francisco CA, USA
- Year and Date
  2011-11-08
- Data Source
  KAKENHI-PROJECT-22590730
[Presentation] Estimation of liver fibrosis by VTTQ (Virtual tissue touch quantification in chronic liver disease: the usefulness of VS/PLT2011
- Author(s)
  Yamada R, Hiramatsu N, Oze T, Harada N, Song C, Inoue Y, Kurokawa M, Miyazaki M, Yakushijin T, Hosui A, Miyagi T, Tatsumi T, Kiso S, Kanto T, Kasahara A, Hayashi N, Takehara T
- Organizer
  The Liver Meeting AASLD 62nd Annual Meeting and Postgraduate Course
- Place of Presentation
  San Francisco CA, USA
- Year and Date
  2011-11-06
- Data Source
  KAKENHI-PROJECT-22590730
[Presentation] Pro-angiogenic receptor TIE2-expressing monocytes/TEM as novel diagnostic biomarker for hepatocellular carcinoma2011
- Author(s)
  Matsubara T, Kanto T, Kuroda S, Yoshio S, Higashitani K, Kakita N, Miyazaki M, Hiramatsu N, Kasahara A, Takehara T
- Organizer
  The Liver Meeting AASLD 62nd Annual Meeting and Postgraduate Course
- Place of Presentation
  San Francisco CA, USA
- Year and Date
  2011-11-07
- Data Source
  KAKENHI-PROJECT-22590730
[Presentation] Viral suppression at week 4 exceeds the IL28B SNP for predicting SVR in pegylated interferon plus ribavirin combination therapy of genotype 1 infected patients with chronic hepatitis.2011
- Author(s)
  Oze T, Hiramatsu N, Yakushijin T, Doi Y, Ogawa H, Hagiwara H, Mita E, Kaneko A, Katayama K, Hijioka T, Tamura S, Yoshihara H, Inoue A, Imai Y, Hayashi E, Hosui A, Miyagi T, Yoshida Y, Tatsumi T, Kiso S, Kanto T, Kasahara A, Hayashi N, Takehara T.
- Organizer
  The Liver Meeting AASLD 62nd Annual Meeting and Postgraduate Course
- Place of Presentation
  San Francisco CA, USA
- Year and Date
  2011-11-06
- Data Source
  KAKENHI-PROJECT-22590730
[Presentation] Indoleamine 2, 3-dioxygenase as an active inducer of regulatory T cells in chronic HCV infection2010
- Author(s)
  Higashitani K, Kanto T, Miyazaki M, Inoue M, Matsubara T, Kakita N, Itose I, Sakakibara M, Hiramatsu N, Takehara T, Kasahara A, Hayashi N
- Organizer
  17thInternational Meeting on Hepatitis C virus and related viruses
- Place of Presentation
  Yokohama Japan
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-22590730
[Presentation] Active role of tryptophan catalyzing enzyme, indoleamine 2, 3-dioxygenase, in the generation of regulatory T cells in chronic hepatitis C patients2010
- Author(s)
  Higashitani K, Kanto T, Miyazaki M, Inoue M, Matsubara T, Kakita N, Itose I, Sakakibara M, Hiramatsu N, Takehara T, Kasahara A, Hayashi N
- Organizer
  The Liver Meeting AASLD 61stAnnual Meeting and Postgraduate Course
- Place of Presentation
  Boston MA
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-22590730

1. SASAKI Yutaka (70235282)

# of Collaborated Projects: 14 results

# of Collaborated Products: 0 results
2. HAYASHI Norio (00144478)

# of Collaborated Projects: 13 results

# of Collaborated Products: 0 results
3. KATAYAMA Kazuhiro

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
4. MITA Eiji

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
5. FUSAMOTO Hideyuki (90124776)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
6. TAKEHARA Tetsuo

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
7. HIRAMATSU Naoki (30362700)

# of Collaborated Projects: 5 results

# of Collaborated Products: 20 results
8. KANTO Tatsuya (80372613)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
9. KAMADA Takenobu (80028399)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. 吉矢生人 (80028505)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 平出敦 (20199037)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. ITO Toshifumi

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. HAGIWARA Hideki

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. Tatsumi Tomohide (20397699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Miyagi Takuya (80532986)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SATO Nobuhiro (90028358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 山本浩司 (60304060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. Yoshioka Teppei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. MOCHIZUKI Kiyoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. OHKAWA Kazuyoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. HORIMOTO Masayoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. IMAI Yutaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. KONO Michikazu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 結城暢一

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 古澤俊一

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. FURUSAWA Shunichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. YOSHIDA Yuuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KASAHARA Akinori 笠原 彰紀

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The role of NK cell in the patients with hepatitis C virus infection; analysis focusing on NK cell receptor and IFN signal transducerPrincipal Investigator

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Investigation for the mechanisms of immune tolerance against HCV mediated by tryptophan-catalyzing enzyme, IDOPrincipal Investigator

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Developmental research of tailored immune-modulation therapy against refractory chronic hepatitis C.Principal Investigator

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Analysis of the molecular mechanism of hepatocarcinogenesis in patients with chronic viral diseases and its application for genetic diagnosis of hepatocellular carcinoma.Principal Investigator

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Analysis of the mechanism of liver damage and carcinogenesis in patients with chronic hepatitis C virus infection.Principal Investigator

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Biomolecular analysis of liver carcinogenesis in hepatitis C virus infection.Principal Investigator

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KASAHARA Akinori 笠原彰紀